PLUNGER AND FINGER GRIP FOR A SYRINGE ASSEMBLY, METHOD FOR MAKING THEM, SYRINGE ASSEMBLY, KIT AND USE OF THE SAME

20230302225 · 2023-09-28

    Inventors

    Cpc classification

    International classification

    Abstract

    The present invention relates to a plunger (20) and a finger grip (30) for a syringe assembly (100), methods for manufacturing them, to a syringe assembly (100), to a kit comprising parts of a syringe assembly (100), and to the use of a syringe assembly (100) or of a kit, wherein the syringe assembly (100) comprises a syringe barrel (10), a finger grip (30) having flanges (31, 32), and a plunger (20) having a plunger rod (21) and a plunger head (22). The plunger (20) comprises a grip pad (23) made by injection molding and attached to a proximal facing surface (24) of the plunger head. The finger grip (20) comprises a grip pad (35) also made by injection molding and attached to a distal facing surface of at least one flange (31, 32) of the finger grip (30).

    Claims

    1. A plunger for a syringe assembly for administering a liquid composition, wherein the plunger comprises a plunger rod and a plunger head, wherein the plunger rod comprises a proximal end and a distal end, and wherein the plunger head is attached to the proximal end of the plunger rod and comprises a proximal facing surface configured to serve as a thumb plate during administering, wherein the plunger comprises a grip pad attached to the proximal facing surface of the plunger head and extending at least partly over said proximal facing surface, wherein the grip pad is made by injection molding.

    2. The plunger according to claim 1, wherein the grip pad on the plunger head is made of a thermoplastic elastomere (TPE), optionally a coloured thermoplastic elastomere (cTPE).

    3. The plunger according to claim 1, wherein the proximal facing surface of the plunger head comprises at least one deepening, optionally at least one groove, which is filled by grip pad injection molding material.

    4. The plunger according to claim 1, wherein the grip pad on the plunger head represents a symbol (“+”), optionally a letter or another character selected from the ASCII-Code.

    5. The plunger according to claim 1, wherein the grip pad on the plunger head is made in one piece comprising one injection point only.

    6. The plunger according to claim 1, wherein the plunger rod comprises at least one section in a longitudinal direction with an at least substantially double-T-profile shape, a double-T-profile-like shape, a I-profile shape or a I-profile-like shape.

    7. A method for manufacturing a plunger according to claim 1, comprising at least: manufacturing the plunger head, forming the grip pad by injection molding.

    8. A finger grip for a syringe assembly for administering a liquid composition, comprising a finger grip body with two flanges extending radially in opposite directions from a center bore in the finger grip body through which a plunger of a syringe assembly can be inserted, each flange serving as a grip portion and having a finger contact area onto which at least one finger of a user can be put partly during administering to support the finger whilst administering, wherein each flange comprises a distal facing surface and a proximal facing surface, wherein the finger grip comprises a grip pad attached to the distal facing surface of at least one of the flanges extending at least partly over said distal facing surface, wherein the grip pad is made by injection molding.

    9. The finger grip according to claim 8, wherein at least one grip pad on the finger grip is made of a thermoplastic elastomere (TPE), optionally a coloured thermoplastic elastomere (cTPE).

    10. The finger grip according to claim 8, wherein at least one grip pad on one of the finger grip flanges is made in one piece comprising one injection point only.

    11. A method for manufacturing a finger grip according to claim 8, comprising at least: manufacturing a finger grip body including two flanges extending radially in opposite directions from a center bore (37) in the finger grip body (30) through which a plunger of a syringe assembly can be inserted, each flange serving as a grip portion and having a finger contact area onto which at least one finger of a user can be put partly during administering to support the finger whilst administering, wherein each flange comprises a distal facing surface and a proximal facing surface, and forming the grip pad by injection molding.

    12. A syringe assembly for administering a liquid composition to a human or animal body, comprising at least: a longitudinal syringe barrel having an inner lumen for receiving and storing a liquid composition to be administered, a finger grip coupled to a proximal end of said barrel, and a plunger having a plunger rod and a plunger head, the plunger rod being disposed at least partly within the inner lumen of the barrel with a distal end thereof, wherein the plunger is a plunger according to claim 1 and/or the finger grip is a finger grip comprising a finger grip body through which the plunger of a syringe assembly can be inserted.

    13. The syringe assembly according to claim 12, wherein the syringe barrel comprises a Luer lock connector at a distal end thereof integrally formed with the syringe barrel, wherein the syringe assembly further comprises a tip cap, the tip cap covering and sealing the distal end of the syringe barrel, wherein the tip cap is a two-part tip cap comprising a rigid part and an elastomeric part, wherein the maximum outer diameter (Dmax) of the rigid part is less or equal to the outer diameter of the Luer lock connector of the syringe barrel.

    14. A kit comprising parts of a syringe assembly according to claim 12, configured to be assembled to a syringe assembly according to claim 12, wherein the kit comprises at least: a longitudinal syringe barrel having an inner lumen for receiving and storing a liquid composition to be administered, a finger grip configured to be coupled to a proximal end of said barrel, and a plunger having a plunger rod and a plunger head, wherein the plunger rod is configured to be disposed at least partly within the inner lumen of said barrel with thereof a distal end thereof, wherein the plunger is a plunger according to claim 1 and/or the finger grip is a finger grip comprising a finger grip body through which the plunger of a syringe assembly can be inserted.

    15. A product comprising a syringe assembly according to claim 12 or a kit thereof for cosmetic or therapeutic application, optionally for replacing or filling a biological tissue or increasing volume of a biological tissue, wherein said product comprises an effective amount of a liquid composition, optionally an effective amount of a dermal filler composition, which is adapted to be administered to a subject.

    Description

    BRIEF DESCRIPTION OF THE DRAWINGS

    [0144] The accompanying drawings, which are incorporated herein and form a part of the specification, illustrate schematically preferred embodiments of the inventions described above, in particular of the present invention, and together with the description, serve to explain the principles and at least partly the features of the described inventions, wherein for same parts same reference signs are used. It is illustrated in:

    [0145] FIG. 1 a perspective view of a first example of an embodiment of a syringe assembly according to the present invention comprising a first example of a plunger according to the present invention and an example of a finger grip according to the present invention,

    [0146] FIG. 2 a perspective view of the second example of an embodiment of the syringe assembly according to the present invention comprising a second example of a plunger according to the present invention and the same finger grip as the syringe assembly in FIG. 1,

    [0147] FIG. 3 a side view of the syringe assembly of FIG. 1,

    [0148] FIG. 4 a longitudinal section through the syringe assembly of FIGS. 1 and 3,

    [0149] FIG. 5 a top view on the proximal facing surface of the plunger of the syringe assembly of FIG. 1,

    [0150] FIG. 6 a top view on the proximal facing surface of the plunger of the syringe assembly of FIG. 2,

    [0151] FIG. 7 a first side view of the plunger of FIG. 1,

    [0152] FIG. 8 a first side view of the plunger of FIG. 1,

    [0153] FIG. 9 a longitudinal section through the plunger of FIG. 1,

    [0154] FIG. 10 an enlarged illustration of a cross section of the plunger of FIG. 10 along A-A′,

    [0155] FIG. 11 an enlarged illustration of the distal end of the plunger shown in FIG. 9,

    [0156] FIG. 12 an enlarged illustration of the proximal end of the plunger shown in FIG. 9,

    [0157] FIG. 13 an enlarged illustration of a bottom view of the piston of the syringe assembly of FIG. 4,

    [0158] FIG. 14 an enlarged illustration of a cross section of the piston of the syringe assembly of FIG. 4,

    [0159] FIG. 15 a first perspective view of the finger grip according to the present invention of the syringe assembly illustrated in some of the previous Figs.,

    [0160] FIG. 16 a second perspective view of the finger grip illustrated in FIG. 15,

    [0161] FIG. 17 a top view of the finger grip illustrated in FIGS. 15 and 16,

    [0162] FIG. 18 a side view of the finger grip illustrated in FIGS. 15 to 17,

    [0163] FIG. 19 a perspective view of the syringe barrel of the syringe assembly illustrated in FIG. 1,

    [0164] FIG. 20 a longitudinal section through the syringe barrel of FIG. 19, and

    [0165] FIG. 21 an enlarged illustration of the tip cap at the distal end of the syringe barrel illustrated in FIG. 20.

    DETAILED DESCRIPTION OF SEVERAL EMBODIMENTS OF THE INVENTION

    [0166] In FIG. 1 a perspective view of a first example of an embodiment of a syringe assembly 100 according to the present invention is illustrated, wherein this syringe assembly 100 comprises a first example of a plunger 20 according to the present invention and an example of a finger grip 30 according to the present invention, wherein the syringe assembly 100 is assembled by parts of an example of a kit according to the present invention, and wherein the plunger 20 respectively the finger 30 each are made by a method according to the present invention.

    [0167] The syringe assembly 100 further comprises a syringe barrel 10 having an inner lumen 13 (see e.g. FIG. 4) being prefilled with a liquid composition (not shown), wherein the liquid composition is a hyaluronic acid dermal filler. The proximal end of the syringe barrel 10 is closed and sealed by a tip cap 40.

    [0168] The plunger 20 can be moved into the syringe barrel 10 along a longitudinal axis A of said syringe barrel 10 for dispensing the composition stored in the inner lumen 13 (see e.g. FIG. 4) of said syringe barrel 10, in particular for ejection of that composition out of the barrel 10 after removing the tip cap 40.

    [0169] The plunger 20 comprises a plunger head 22 and a plunger rod 21 each made by injection molding of polypropylene PP, wherein the plunger head 22 and the plunger rod 21 are made in one piece. That means, they are integrally molded. The plunger head 22 comprises a proximal facing surface 24 onto which also by injection molding a grip pad 23 has been applied for facilitating gripping respectively for improving a contact of a user's thumb. The grip pad 23 is made of thermoplastic elastomere (TPE) which allows a safe and precise support of the thumb of a user during use of said syringe assembly 100 and therewith a precise administering of the composition stored in the syringe barrel 10.

    [0170] In this example of a plunger 20 according to the present invention the grip pad 23 attached to the plunger head 22 is made in one piece via one injection point 26 only (see FIG. 5). The grip pad 23 extends almost over the whole proximal facing surface 24 of the plunger head 22 except of some areas not being filled or covered with grip pad material 23. In this example of a plunger 20 according to the present invention the areas not being filled or covered with grip pad material are completely surrounded by grip pad material 23.

    [0171] Due to the fact that compositions as the hyaluronic acid dermal filler being stored in the syringe barrel 10 of syringe assembly 100 require high extrusion forces respectively high ejection forces because of their high viscosity, plunger rod 21 has to be resistive against kinking. To avoid mechanical failure of the plunger rod 21 during use, the plunger rod 21 has a double-mushroom shaped profile almost over its whole length, see also FIGS. 4 and 7 to 10. Thereby, a very good mechanical strength can be achieved, in particular also for plungers 20 configured to be used with syringe barrels 10 for syringe assemblies 100 and 200 as illustrated in FIGS. 1 and 2, which are configured for receiving and storing an amount of 1 ml of the composition to be administered, wherein the inner lumen 13 of the syringe barrel 10 has a relatively small inner diameter, in particular a smaller inner diameter and a greater length compared to an inner lumen of a standard syringe barrel according to standard ISO11040-6. By the reduced inner diameter of the inner lumen 13, i.e. by its smaller inner diameter, the extrusion forces during use can be reduced, what also helps to reduce the risk of mechanical failure of the plunger 20, in particular of the plunger rod 21. In an alternative embodiment, plunger rod 21 may comprise a massive cross-section in particular an oval or a circular or a square cross-section, wherein said massive, in particular oval or circular or square cross-section, may extend only over one section of the length of the plunger rod 21 or over several sections in longitudinal direction of the plunger rod 21 or may extend over the complete length of the plunger rod 21. Size and geometry of the cross-section of the plunger rod 21 may be constant over the length of plunger rod 21 or vary. In one embodiment, the geometry and/or size of the cross-section area of the plunger rod may, for example, be constant over at least 80% or 90% of the complete length of the plunger rod.

    [0172] The finger grip 30 comprises a finger grip body, also made by injection molding of polypropylene PP in one piece, having two flanges or wings 31 and 32 extending radially in opposite directions from a center bore 37 in the finger grip body. Through the center bore 37 the plunger 20 is inserted. The wings 31, 32 are extending to the right respectively to the left of the center bore 37. Each wing 31, 32 serves as a grip portion and has a finger contact area 35 onto which at least one finger of a user can be put partly during administering of the composition stored in the syringe barrel 10 to support the finger whilst administering, wherein each wing 31, 32 comprises a distal facing surface 33 and proximal facing surface 34.

    [0173] According to the present invention, the finger grip 30 comprises at least one grip pad 35, in this example two grip pads 35, wherein each grip pad is attached to the distal facing surface 33 of one of the wings 31, 32 and extends almost over the whole distal facing surface 33. Both grip pads 35 are made by injection molding, wherein the grip pads 35 in this example of a finger grip 30 according to the present invention have been applied directly onto the distal facing surfaces 33 when injection molded.

    [0174] The grip pads 35 attached to the flanges 31 and 32 also made of a thermoplastic elastomer (TPE) in one piece each having one injection point 26 (see FIGS. 16 and 17) only. These grip pads 35 also improve grasping of the syringe assembly 100 and help prevent slipping of the user's fingers during administering of the composition stored in the syringe barrel 10.

    [0175] The grip pads 35 of the finger grip 30 also comprise areas 36 not being filled with grip pad injection molding material 35, wherein these areas are forming parallel and transversally extending stripes 36 completely being surrounded by grip pad material 35.

    [0176] The finger grip 30 is coupled to the proximal end of the syringe barrel 10 by a flange 12 (see e.g. FIG. 4) formed at the proximal end of the syringe barrel 10, wherein flange 12 is inserted into a side slot 38 in the finger grip 30 (see e.g. FIG. 4). Through the center bore 37 the plunger rod 21 of the plunger 20 is inserted such that the plunger rod 21 is disposed with its distal end at least partly in the inner lumen 13 of the syringe barrel 10.

    [0177] For easy distinguishing and avoiding mis-administering of the composition stored in the syringe barrel 10 of the syringe assembly 100, the grip pad 23 attached to the plunger head 22 and the grip pads 35 attached to the finger grip body 30 respectively to its wings 31 and 32 are made of colored grip pad material, in particular of colored TPE, wherein the color is associated to that particular composition of a hyaluronic acid dermal filler stored in the syringe barrel 10. This allows a medical practitioner to recognize at the first glance which composition the respective syringe assembly 100 intended to be used contains.

    [0178] In FIG. 2 a second example of an alternative embodiment of a syringe assembly 200 according to the present invention is shown, wherein in this embodiment 200 the grip pad 23 attached to the plunger head 22, in particular its proximal facing surface 24, is designed in such a way that it represents a symbol, in particular a “+”. In this case, that symbol “+” is associated to a composition containing the active ingredient Lidocaine. This design of the grip pad 23 of the plunger 20 allows a medical practitioner to recognize at a first glance, that a syringe assembly 200 being filled with a composition containing Lidocaine has been chosen. Thereby, the risk of mis-administering caused by mixing up syringe assemblies containing different compositions to be administered can be reduced.

    [0179] FIG. 3 shows a side view of the syringe assembly 100 illustrated in FIG. 2, wherein in this illustration the arrangement of the grip pads 35 on the finger grip 30, in particular its distal facing surfaces 33 is visible clearly.

    [0180] FIG. 4 shows a longitudinal section through the syringe assembly 100 of FIGS. 1 and 3, wherein in this illustration the coupling of the plunger 20, in particular of the plunger rod 21, with the syringe barrel 10 and the finger grip 30 and as well the coupling between the finger grip 30 and the syringe barrel 10 can be seen.

    [0181] In particular from the illustration in FIG. 4 can be seen, how flange 12 at the proximal end of the syringe barrel 10 is inserted into the slot 38 in the finger grip 30 for coupling of the syringe barrel 10 to the finger grip body 30. Further it can be seen that the distal end of the plunger rod 21 is inserted through the center bore 37 into the inner lumen of the syringe barrel 10. At its distal end 25 the plunger 20 is coupled to a piston 50, in particular by a snap-fit connection, wherein the piston 50 in this example of a syringe assembly 100 is made of FM257 what an elastomeric material is.

    [0182] To achieve good adhesion between the grip pad 23 and the proximal facing surface 24 of the plunger head 22 and between the grip pads 35 and the distal facing surfaces 33 of the finger grip body 30, the surfaces to which the grip pads 23 respectively 35 are applied comprises several grooves 27, 39 each (see FIGS. 4 and 12), which are filled by grip pad injection molding material during injection molding of the grip pads 23, 35.

    [0183] FIG. 4 further shows the closing and sealing of the distal end of the syringe barrel 10 by the tip cap 40 in detail. For coupling said tip cap 40 to the syringe barrel 10 the syringe barrel 10 comprises a Luer lock connector 11 at its distal end. The tip cap 40 comprises a rigid outer part 41 and an elastomeric inner part 42. The rigid outer part 41 is threadedly engaged with the inner threads of the Luer lock connector 11. The elastomeric inner part 42 of the tip cap 40 is inserted into the rigid outer part 41 extending partly with a frustoconical protrusion into an outlet channel 15 of the distal end of the syringe barrel 10, see also FIGS. 20 and 21.

    [0184] FIG. 5 shows a top view of the plunger 20 of the syringe assembly 100 illustrated in FIG. 1, wherein in FIG. 5 the one and only injection point 26 used for manufacturing of the in one piece made grip pad 23 is indicated. In this example, the injection point 26 is located near the outer edge of the grip pad 23. For improved adhesion of the grip pad injection molding material 23 to the proximal facing surface 24 of the plunger head 22 of plunger 20, the plunger 20 is made by an injection tool (not shown) having a tool surface, which is responsible for shaping of the proximal facing surface 24, which has been eroded resulting in a surface roughness according to VDI 3400 Ref. 27 with Ra=2.24 μm and Rmax=9.0 μm.

    [0185] FIG. 6 shows a top view of the plunger 20 of the syringe assembly 200 is illustrated in FIG. 2, wherein the grip pad 23 attached to the proximal facing surface 24 of the plunger head 22 of this plunger 20 is also made in one piece by injection molding by using one injection point 26 only. The injection point 26 is also located near the outer edge respectively the outer circumference of grip pad 23. In difference to the grip pad 23 of the plunger 20 illustrated in FIG. 5, the grip pad 23 of the plunger illustrated in FIG. 6 is designed in such a way that it represents a symbol, in particular a “+”, as already described in relation to FIG. 2, by which is indicated that the composition the syringe barrel 10 of the syringe assembly 200 is prefilled with, contains Lidocaine.

    [0186] FIGS. 7 and 8 show different side views of the plunger 20 of the syringe assembly 100 as illustrated in FIG. 1, wherein the illustration in FIG. 8 shows the plunger 20 rotated about 90° around its longitudinal axis A compared to the illustration in FIG. 7.

    [0187] FIG. 9 shows an illustration of a longitudinal section of the plunger 20 in accordance with FIGS. 1, 7 and 8, wherein in FIG. 9 the double-mushroom-shaped profile of the plunger rod 21 is visible.

    [0188] FIG. 10 shows an enlarged illustration of a cross section of the plunger of FIG. 10 along section plane A-A′ by which the double profile of the plunger rod 21 becomes apparent.

    [0189] FIG. 11 shows an enlarged illustration of the distal end 25 of the previously described plunger 20 illustrated in FIG. 9, wherein the plunger rod 21 can be coupled with its distal end 25 to a piston by a snap fit connection (see e.g. FIGS. 4 and 14—piston 50). The distal end 25 of the plunger rod 21 comprises a mushroom-shaped tip 25A. In this example, the plunger tip 25 further comprises a piston receiving section 25B arranged adjacent to the mushroom-shaped tip 25A a in proximal direction having a smaller diameter than the mushroom-shaped tip 25A. The piston receiving section 25B is limited in proximal direction by a plate disc-shaped axial piston stop 25C for axial fixation of a piston (not shown apparently here). Thereby, a secure connection between the distal end 25 of the plunger rod 21 and a piston 50 can be achieved.

    [0190] FIG. 12 shows an enlarged illustration of the proximal end of the plunger 20 shown in FIG. 9. The proximal facing surface 24 of plunger head 22 comprises two circular grooves 27 arranged concentric around the longitudinal axis A, wherein the grooves have been filled by grip pad injection molding material 23 during applying the grip pad material 23 onto the proximal facing surface 24 of the plunger head 22. By these grooves 27 the contact area between the proximal facing surface 24 and the grip pad material 23 can be increased, resulting in better adhesion between the grip pad material 23 and the plunger head 22.

    [0191] FIG. 13 shows an enlarged illustration of a bottom view of the piston 50 of the syringe assembly 100 illustrated in FIG. 4 and FIG. 14 an enlarged illustration of a cross section of said piston 50, wherein said piston 50 is configured to be snap-fit connected with the mushroom-shaped tip 25 of plunger rod 21. For a tight fit with the walls of the inner lumen 13 of the syringe barrel 10 said piston 50 comprises a wave-shaped outer geometry. On its bottom side 51, the piston 50 comprises several protrusions not indicated configured to get in contact with the axial piston stop 25C of the plunger rod 21.

    [0192] FIGS. 15 to 18 show different views of the example of the finger grip 30 according to the present invention of the syringe assemblies 100 and 200 as illustrated in FIGS. 1 and 2, wherein from FIGS. 15 to 18 in particular the curved shape of the wings 31 and 32, the design and arrangement of the grip pads 35 on the distal facing surfaces 33, the center bore 37 and the side slot 38 for coupling of the finger grip 30 to the proximal end of the syringe barrel 10 become apparent.

    [0193] Like the plunger head grip pads 23 of the plunger 20 of the syringe assemblies 100 and 200 illustrated in FIGS. 1 and 2, also the grip pads 35 of the finger grip 30 are made by injection molding. The grip pads 35 are also made in one piece of colored TPE by using one injection point 26 only, wherein the grip pad material 35 has been applied to the distal facing surfaces 33 of the wings 31, 32 directly. The injection points 26 are also located at the outer edge of the grip pads 35, which also extend almost completely over the corresponding surface 33. As described above, some areas 36 forming parallel and transversal extending stripes 36 are not being filled or covered with grip pad material 35, but are completely surrounded by the grip pad material 35 to achieve a good economic haptic and a good finger contact with a reduced risk of slipping of any finger of a user.

    [0194] FIG. 19 shows a perspective individual view of the syringe barrel 10 of the syringe assembly 100 as illustrated in FIG. 1, wherein the inner lumen 13 of said barrel 10 is prefilled with a hyaluronic acid dermal filler. The distal end of said barrel 10 is closed and sealed by the tip cap 40. The proximal end of the syringe barrel 10 comprises a flange 12, which can be inserted laterally into the slot 38 of the finger grip 30 for coupling of said syringe barrel 10 to the finger grip 30 respectively the finger grip 30 to said barrel 10.

    [0195] FIG. 20 shows a longitudinal section through the barrel 10 of FIG. 19.

    [0196] FIG. 21 shows an enlarged illustration of the tip cap 40 of FIG. 20. As can be seen, the syringe barrel 10 comprises a Luer lock connector 11 at its distal end, wherein the Luer connector comprises inner threads and a Luer cone 14 surrounding an outlet channel 15, which is in fluid communication with the inner lumen 13 of the syringe barrel 10.

    [0197] The distal end of the syringe barrel 10 is closed and sealed by the tip cap 40, which comprises an outer rigid part 41, engaged with the inner threads of the Luer lock connector 11, and an inner elastomeric part 42, which is inserted into the outer rigid part 41 thereby closing and sealing the outlet channel 15 of the syringe barrel 10.

    [0198] In this example, the maximum outer diameter Dmax of the rigid part 41 is less or equal to the outer diameter of the Luer connector 11 of the syringe barrel 11. Thereby a risk of unintended snagging or damage of the tip cap 40 and therewith of the closing and sealing of the prefilled syringe barrel 10 can be reduced. In particular, the outer wall of the rigid part is at least partly in flush with the outer wall of the Luer lock connector.

    [0199] All of the features described herein with respect to one aspect of the present invention may also be realized alone or in combination in any other of the subjects according to any other aspect of the present invention, so far this is technically possible.

    LIST OF REFERENCE SIGNS

    [0200] 100 first example of an embodiment of a syringe assembly according to the present invention [0201] 200 second example of an embodiment of a syringe assembly according to the present invention [0202] 10 syringe barrel [0203] 11 Luer lock connector [0204] 12 flange of the syringe barrel at the proximal end of the syringe barrel [0205] 13 Luer cone of the Luer lock connector [0206] 15 outlet channel [0207] 20 example of an embodiment of a plunger according to the present invention [0208] 21 plunger rod [0209] 22 plunger head [0210] 23 grip pad of the plunger head [0211] 24 proximal facing surface of the plunger head [0212] 25 plunger tip at the distal end of the plunger rod [0213] 25A mushroom-shaped tip of the plunger rod [0214] 25B piston receiving portion [0215] 25C axial piston stop [0216] 26 injection point [0217] 27 groove in the proximal facing surface of the plunger head [0218] 30 example of an embodiment of the finger grip according to the present invention [0219] 31 right flange or wing of the finger grip body [0220] 32 left flange or wing of the finger grip body [0221] 33 distal facing surface of the finger grip body [0222] 34 proximal facing surface of the finger grip body [0223] 35 grip pad of the finger grip [0224] 36 area not being filled or covered by grip pad injection molding material of the [0225] finger grip designed as a stripe [0226] 37 center bore in the finger grip body [0227] 38 slot for finally insertion of a proximal flange of a syringe barrel [0228] 39 groove in the distal facing surface of the finger grip body [0229] 40 tip cap [0230] 41 rigid part of the tip cap (outer part) [0231] 42 elastomeric part of the tip cap (inner part) [0232] 50 piston [0233] 51 bottom side of the piston [0234] A longitudinal axis of the syringe barrel [0235] Dmax maximum outer diameter of the rigid part of the tip cap