Abstract
An injection device for subcutaneous delivery of fluid which comprises a puncture cannula and an indwelling cannula. In a starting position, a distal end region of the puncture cannula runs coaxially inside the indwelling cannula. The device comprises displaceably mounted first and second runners. The first runner is connected to the puncture cannula and the second runner to the indwelling cannula. A control element is movable over a predefined control area. The control element is configured such that, in a first part of the control area, the control element effects an equidirectional displacement of the first and the second runners, and hence fitting of the indwelling cannula and, in a second part of the control area, effects blocking of the second runner, and hence holding of the indwelling cannula in a dwell position, and return of the first runner and withdrawal of the puncture cannula into an end position.
Claims
1. A dosing apparatus for subcutaneous, intradermal, intramuscular or intraperitoneal delivery of a fluid, the dosing apparatus comprising: a conveying device for conveying the fluid out of an interior of a container, and the fluid being conveyable by means of the conveying device from the container to a delivery opening; an injection device for subcutaneous delivery of the fluid, comprising a puncture cannula, and an indwelling cannula; the conveying device being designed as a positive displacement pump, the conveying device comprising a cylinder, having at least one intake opening and at least one outlet opening on a cylinder inner wall, and a first piston and a second piston, the first piston and the second piston are mounted displaceably within the cylinder in a longitudinal direction, and the first and second pistons delimit between their respective end faces, jointly with a portion of the cylinder inner wall, a variable fluid volume; and a barrel cam having a first cam structure and a second cam structure arranged alongside the cylinder, wherein the first cam structure is in operative connection with the first piston via a first fork-shaped element and the second cam structure is in operative connection with the second piston via a second fork-shaped element, and wherein, upon rotation of the barrel cam, the first cam structure rotates within the first fork-shaped element to thereby prescribe a stroke movement of the first piston and the second cam structure rotates within the second fork-shaped element to thereby prescribe a stroke movement of the second piston, wherein the barrel cam is in operative connection both with the injection device and with the conveying device such that the barrel cam serves simultaneously to control the injection device and to drive the conveying device, and wherein a proximal end region of the puncture cannula is fluidically connected to the at least one outlet opening of the conveying device.
2. The dosing apparatus according to claim 1, wherein in a starting position a distal end region of the puncture cannula runs coaxially inside the indwelling cannula, the injection device comprises displaceably mounted first and second runners, the first runner is connected to the puncture cannula and the second runner to the indwelling cannula, the injection device further comprises a control element, which is movable over a predefined control area and which, for displacement of the first runner and of the second runner, is brought into operative connection with the first and second runners, and the control element is configured such that, in a first part of the control area, the control element effects equidirectional displacement of the first and second runners, and, in a second part of the control area, effects blocking of the second runner, and hence holding of the indwelling cannula in a dwell position, and a back shift of the first runner, and hence withdrawal of the puncture cannula from a distal end region of the indwelling cannula into an end position, and the first and second runners are mounted displaceably via a guide device.
3. The dosing apparatus according to claim 2, wherein the puncture cannula and the indwelling cannula, in the starting position, are arranged substantially within a housing and, for the fitting of the indwelling cannula, are extensible from the housing through a fitting opening in a contact surface.
4. The dosing apparatus according to claim 2, comprising a drive module and a delivery module, which are configured such that the drive module and the delivery module are at least one of connectable to or disconnectable from one another, by a user, the drive module comprises at least parts of a rotary drive, and, where appropriate, a fitting drive of the injection device, and the delivery module comprises at least the container and the conveying device.
5. The dosing apparatus according to claim 2, wherein the first and second runners are mounted displaceably, via the guide device.
6. The dosing apparatus according to claim 5, wherein the control element is movably mounted in a direction substantially perpendicular to that of the linear guide device.
7. The dosing apparatus according to claim 2, wherein the first and second runners are mounted displaceably, via the guide device, and the guide device is oriented in a fitting direction parallel to the distal end regions of the puncture cannula and of the indwelling cannula.
8. The dosing apparatus according to claim 7, wherein the control element is movably mounted in a direction substantially perpendicular to that of the guide device.
9. The dosing apparatus according to claim 2, wherein the control element is configured as a displaceable cam carrier.
10. The dosing apparatus according to claim 2, wherein the control element comprises first and second portions, the first portion effects an equidirectional displacement of the first and second runners, and the second portion effects blocking of the second runner, and hence holding of the indwelling cannula in the dwell position, as well as the backshift of the first runner, and hence withdrawal of the puncture cannula from the distal end region of the in-dwelling cannula into the end position, and sides of the second portion act on the first and second runners.
11. The dosing apparatus according to claim 1, wherein the at least one intake opening is brought into fluidic connection with the interior of the container.
12. The dosing apparatus according to claim 11, comprising a plurality of containers in addition to said container, and each intake opening is brought into fluidic connection with the interior of a separate container of said plurality of containers which is assigned to said intake opening.
13. The dosing apparatus according to claim 1, wherein the at least one outlet opening is brought into fluidic connection with the delivery opening.
Description
(1) Further advantages and detailed features of the invention emerge from the following description of an illustrative embodiment and from the drawings, wherein, in schematic portrayal:
(2) FIG. 1: shows a perspective representation of a dosing apparatus according to the invention
(3) FIG. 2: shows a representation according to FIG. 1, but with a section through the dosing apparatus according to the invention;
(4) FIG. 3: shows a representation according to FIGS. 1 and 2, but with another section through the dosing apparatus according to the invention;
(5) FIG. 4: shows a representation according to FIGS. 1 to 3, but in partial enlargement and with a further section through the dosing apparatus according to the invention;
(6) FIGS. 5-18: show a sequence of steps, which shows the fitting of an indwelling cannula of an injection device according to the invention, wherein the odd-numbered figures respectively show the dosing apparatus in top view, and the following even-numbered figures respectively show the injection device in the corresponding state in spatial representation;
(7) FIG. 19: shows a perspective sectional view of a dosing apparatus according to the invention with an indwelling cannula in dwell position;
(8) FIG. 20: shows a perspective representation of a dosing apparatus according to the invention with injection device and conveying device;
(9) FIG. 21: shows a perspective representation of the conveying device of a dosing apparatus according to the invention;
(10) FIG. 22: shows a section through a representation according to FIG. 21;
(11) FIG. 23: shows a top view of a segment of a dosing apparatus according to the invention in a first operating position;
(12) FIG. 24: shows a representation according to FIG. 23, but with the dosing apparatus in a second operating position;
(13) FIGS. 25-28: show a perspective representation of a sequence of steps, which shows the fitting of an indwelling cannula of an alternative illustrative embodiment of an injection device according to the invention.
(14) In FIG. 1, a dosing apparatus 20 according to the invention is represented, wherein, for better clarity, only the injection device 1 with the barrel cam 18 and the rotary drive 36 are represented. The conveying device 21 and further components of the dosing apparatus 20, such as, for instance, a control unit or a battery, are omitted for better clarity. The dosing apparatus 20 has a housing 7, the bottom side of which forms a contact surface 8 for attaching the apparatus 20 to a patient. The injection device 1 comprises the control element 6, which can be brought into operative connection with the first runner 4 and the second runner 5. The control element 6 is pretensioned via the spring element 17. However, it is held back by the barrel cam 18 held back against the pretension.
(15) In the sectional view according to FIG. 2 can clearly be seen the linear guide 11 with which the first runner 4 and the second runner 5 are guided. In FIG. 3, the control element 6 can be seen. It is apparent that this is configured as a pair of congruent, displaceable cam carriers 12, 12′. Of the front cam carrier 12, both portions 13 and 14 are visible.
(16) In FIG. 4, that segment of the dosing apparatus comprising the injection device 1 is shown in enlarged representation. In comparison to FIGS. 2 and 3, the sectional plane is offset further to the rear, so that this now runs in the longitudinal direction through the puncture cannula 2 and the indwelling cannula 3. Since the section also runs through the control element 6, the rear cam carrier 12′, comprising the two portions 13′ and 14′, is now visible. It can be seen that the puncture cannula 2, in the starting position of the injection device 1, runs in the longitudinal direction within the indwelling cannula 3. On the bottom side of the housing 7 is provided a fitting opening 9, which penetrates the contact surface 8. The second runner 5 is designed as a holding plate, to which is attached a seal 19 which seals the transition between the fitting cannula 2 and the indwelling cannula 3.
(17) FIGS. 5 and 6 show the injection device 1 in its starting position. The barrel cam 18 has still not performed a rotary movement. In FIG. 6, it can be seen that the first portion 13 of the cam carrier 12 and the first portion 13′ of the second cam carrier 12′ are not yet in operative connection with the first runner 4 and the second runner 5.
(18) FIGS. 7 and 8 show the injection device 1 at the beginning of the fitting process. The barrel cam 18 has already rotated through a few degrees. The first regions 13, 13′ of the cam carriers 12, 12′ are now in operative connection with the second runner 5.
(19) FIGS. 9 and 10 show the injection device 1 during the actual fitting process. In FIG. 9, it can be seen that the barrel cam 18 has now rotated to the point where it no longer holds back the control element 6 against the pretension of the spring element 17. Accordingly, the control element 6 can move freely, whereby the first portions 13, 13′ of the cam carriers 12, 12′ press the first runner 4 and the second runner 5 downward.
(20) In FIGS. 11 and 12, the first runner 4 and the second runner 5 have arrived at their lower stop point. The puncture cannula 2 is hence fitted in place. In FIG. 11 it can be seen that the control element 6 has only covered about half of its path and moves onward under the spring preload.
(21) In FIGS. 13 and 14, the first runner 4 and the second runner 5 are now in operative connection with the second portions 14, 14′ of the cam carriers 12, 12′. The top side 15 and 15′, respectively, of the second portions 14, 14′ here acts on the first runner 4, whereby the fitting cannula 2 is withdrawn upward from the indwelling cannula 3. On the second runner 5 acts the bottom side 16 and 16′, respectively, of the second portions 14, 14′. This leads to a locking of the second runner 5, and hence of the indwelling cannula 3, in its dwell position.
(22) FIGS. 15 and 16 show the upward withdrawal of the fitting cannula 2 from the indwelling cannula 3. Here too, the first runner 4 is pressed upward from the bottom side 15 and 15′, respectively, of the second portions 14, 14′.
(23) In FIGS. 17 and 18, the control element 16 has reached its stop on the barrel cam 18. It is no longer further movable by the spring element 17. It can be seen that the first runner 4 has reached its end position, whereas the second runner 5, and hence the indwelling cannula 3, are still locked in the dwell position.
(24) FIG. 19 shows a sectional view of the injection device 1 in the dosing apparatus 20 in its end position. The indwelling cannula 3 now juts out of the fitting opening 9, while the puncture cannula 2 is substantially withdrawn. Also discernible is the sealing element 19, which is squeezed by the second runner 5 and the housing 7 of the apparatus 20. As a result, a better seal at the transition from the fitting cannula 2 to the indwelling cannula 3 can be obtained.
(25) FIG. 20 shows a spatial representation of the dosing apparatus 20 according to the invention, though now also with the conveying device 21. It can be seen that the barrel cam 18 is in operative connection both with the injection device 1 and with the conveying device 21. The barrel cam 18 hence serves simultaneously to control the injection device 1 and to drive the conveying device 21. The proximal end region of the puncture cannula 21 is fluidically connected to the exit opening 27 of the conveying device 21.
(26) In FIG. 21, the conveying device 21, in combination with the barrel cam 18 and the rotary drive 36, is represented in isolation. It can be seen that the conveying device 21 is designed as a double-piston pump comprising the cylinders 25 and the pistons 29 and 30. Respectively attached to the pistons 29 and 30 are fork-shaped elements 22 and 23, in which bead-like cam elements 34 and 35 of the barrel cam 18 engage.
(27) FIG. 22 shows a diagram corresponding to FIG. 21, with a section along the longitudinal center axis of the cylinder 25. It can be seen that the pistons 29 and 30 are equipped in their end regions with the sealing elements 37 and 38. The end faces 31 and 32 of the pistons 29 and 30 form jointly with the inner wall 28 of the cylinder 25 a variable fluid volume 33. The entry opening 26 and the outlet opening 27 of the conveying device 21 are provided offset in the longitudinal direction on the cylinder 25.
(28) FIGS. 23 and 24 show a top view of a segment of the dosing apparatus according to the invention before and after the fitting process. It can be seen that the fitting process is triggered with the rotary drive 36 via a rotation of the barrel cam 18. The displacement of the control element 6 is realized, however, mainly by the preload of the spring element 17. Through the rotation of the barrel cam 18, a longitudinal displacement of the cylinders 29 and 30 within the piston 25, moreover, ensues.
(29) FIGS. 25 to 28 show an alternative illustrative embodiment of an injection device 1 according to the invention. In FIG. 25, said device 1 can be seen in its starting position. The control element 6 is pretensioned via a spring element 17, which is here configured as a helical spring. The control element 6 is held back against the pretension by a stop element 38, which rests on a stop plate 39. By actuation of the release button 37 (in the arrow direction), the stop plate 39 is displaced in a direction perpendicular to the direction of displacement of the control element 6. As a result, the stop element 38 can slide through the recess 40 in the stop plate 39 and trigger the actual fitting process.
(30) In FIG. 25 are additionally illustrated the cam surfaces 10, 10′, 10″, 10″′, 10″″ of the cam carrier 12, which prescribe the movement of the first runner 4 and of the second runner 5 over the control area.
(31) In FIGS. 25 to 28, only parts of the injection device 1 are represented. The non-shown parts generally correspond to those according to FIGS. 1 to 25. In particular, the linear guides 11 (indicated in FIG. 25 only in dashed representation) are substantially identical to those in the preceding figures.
(32) In FIG. 26, the control element 6 is already displaced over the first part of the control area (in the arrow direction). This has led, by means of the surface 10″″, to a simultaneous-equidirectional displacement of the two runners 4, 5, and hence to a fitting of the indwelling cannula 3 with the aid of the puncture cannula 2.
(33) Obviously, during the displacement of the control element 6, an expansion of the helical spring 17 ensues. For technical drawing reasons, this latter is shown in FIGS. 25 to 28, however, always in the compressed state.
(34) FIG. 27 shows the displacement of the control element 6 over a second part of the control area. On the one hand, a blocking of the second runner 5, designed as a holding plate, and hence a holding of the indwelling cannula 3 in the dwell position, is here obtained merely by action, especially downpressing, by the control element 6 with the cam surface 10. On the other hand, by means of the cam surface 10″, a withdrawal of the puncture cannula 2 from the distal end region of the indwelling cannula 3 is obtained.
(35) The control element 6 has an additional cam surface 41, which in the second part of the control area acts on the lever element 42. The lever element 42 is thereby movable from the first position, shown in FIG. 27, into a second position, depicted in FIG. 28, whereby a rotation of a pivot pin 43 ensues. The control element 6 can hence control further functions of an appropriate device, for instance a dosing apparatus. Thus, an activation of a valve device or conveying device in order to conduct a fluid to the injection device can be realized.
