Novel Treatments of Glaucoma

Abstract

Glaucoma or pathogenic intraocular pressure is treated by locally administering to an eye in need thereof formulations of a Wnt5a receptor inhibitor.

Claims

1. A method of treating glaucoma or pathogenic intraocular pressure, comprising administering to a person in need thereof an inhibitor of an ocular Wnt5a effector.

2. The method of claim 1 wherein the Wnt5a effector is selected from: FZD2 (frizzled-2), FZD5 (frizzled-5) and ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1); or PLCB1 (phospholipase C, beta 1), PPP3R1 (Protein Phosphatase 3 Regulatory Subunit B, Alpha), NFATC3 (Nuclear Factor of Activated T Cells 3) and CAMK2D (Calcium/Calmodulin Dependent Protein Kinase II Delta).

2. The method of claim 1, wherein the inhibitor inhibits effector expression through a genetic manipulation selected from CRISPR gene editing and siRNA.

3. The method of claim 1, wherein the inhibitor inhibits the effector directly and is selected from an antibody, a small interfering peptide, and a small molecule inhibitor.

4. The method of claim 1, wherein the administering step comprises locally administering the inhibitor to an eye in need thereof.

5. The method of claim 1, wherein the administering step comprises delivery by eye drop or by intracameral administration or injection, subconjuctival administration or injection or intravitreal administration or injection.

6. The method of claim 1, wherein the administration is topical, and the inhibitor is administered in form of a topical ophthalmic gel, ointment, suspension or solution or contact lens.

7. The method of claim 1 wherein the inhibitor is a Wnt5a effector specific antibody.

8. The method of claim 1 wherein the inhibitor is a Wnt5a effector specific antibody that is cirmtuzumab.

9. The method of claim 1 wherein the inhibitor is a Wnt5a effector specific small molecule selected from compounds #1-#331 of Table KAN0439834 and related 2-phenyl-3H -imidazo[4,5-b]pyridine ROR1 inhibitors, supra.

10. The method of claim 1 wherein the inhibitor is a Wnt5a effector specific small molecule selected from compounds #2, 3, 11, 15, 19, 27, 34, 43, 56, 64, 71, 75, 82, 96, 99, 117, 132, 147, 159, 168, 184, 232, 259, 265, 272, 288, 294, 302 of Table KAN0439834 and related 2-phenyl-3H-imidazo[4,5-b]pyridine ROR1 inhibitors, supra.

11. The method of claim 1 wherein the inhibitor is a Wnt5a effector specific small molecule that is KAN0439834.

12. The method of claim 1 wherein the inhibitor is a Wnt5a effector specific siRNA and the effector is selected from ROR1, FZD2, FZD5, CAMK2D, PLCB1, PPP3R1 and NFATC3.

13. The method of claim 1 wherein the inhibitor is a Wnt5a effector specific siRNA and the effector is selected from ROR1, FZD2, FZD5, CAMK2D, PLCB1, PPP3R1 and NFATC3, and the siRNA comprises a sequences selected from SEQ ID 1-16 of Table, Human siRNA sequences, supra.

14. The method of claim 1, further comprising administering or coadministering locally at the eye a second, different inhibitor that is an inhibitor of an ocular Wnt5a effector.

15. The method of claim 7, wherein the administration is topical, and the inhibitor is administered in form of a topical ophthalmic gel, ointment, suspension or solution or contact lens.

16. The method of claim 8, wherein the administration is topical, and the inhibitor is administered in form of a topical ophthalmic gel, ointment, suspension or solution or contact lens.

17. The method of claim 9, wherein the administration is topical, and the inhibitor is administered in form of a topical ophthalmic gel, ointment, suspension or solution or contact lens.

18. The method of claim 11, wherein the administration is topical, and the inhibitor is administered in form of a topical ophthalmic gel, ointment, suspension or solution or contact lens.

19. The method of claim 12, wherein the administration is topical, and the inhibitor is administered in form of a topical ophthalmic gel, ointment, suspension or solution or contact lens.

20. The method of claim 13, wherein the administration is topical, and the inhibitor is administered in form of a topical ophthalmic gel, ointment, suspension or solution or contact lens; or a composition that is an ophthalmic formulation of an inhibitor of an ocular Wnt5a effector, in unit dosage form, configured for a method for treating glaucoma or pathogenic intraocular pressure, the effector selected from: FZD2 (frizzled-2), FZD5 (frizzled-5) and ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1); or PLCB1 (phospholipase C, beta 1), PPP3R1 (Protein Phosphatase 3 Regulatory Subunit B, Alpha), NFATC3 (Nuclear Factor of Activated T Cells 3) and CAMK2D (Calcium/Calmodulin Dependent Protein Kinase II Delta), and preferably: the inhibitor inhibits effector expression through genetic manipulation, such as CRISPR gene editing or siRNA; the inhibitor inhibits the effector directly and is selected from an antibody, a small interfering peptide, and a small molecule inhibitor; in the form of a topical ophthalmic gel, ointment, suspension or solution; the dosage form is an inhibitor-loaded contact lens, eye drop, depot or bollus; packaged in an eye drop dispenser; loaded in a syringe configured for intracameral administration or injection, subconjuctival administration or injection or intravitreal administration or injection; further comprising excipients and features suitable for direct, topical delivery to the eye, selected from the group consisting of opthalmically suitable clarity, pH buffer, tonicity, viscosity, stability and sterility; and/or the inhibitor is a ROR1 inhibitor, such as selected from cirmtuzumab and KAN0439834, or a FZD5 inhibitor, such as selected from anti-FZD5 antibodies IgG-2919 and IgG-2921, or a FZD2 inhibitor, such as selected from dFz7-21, a selective peptide, or FZD2 antibody or an siRNA such as disclosed herein.

Description

BRIEF DESCRIPTION OF THE FIGURES

[0030] FIGS. 1A-G. (A-C) Real-time quantitative PCR data showing the expression levels of FZD5, ROR1 and FZD2 in human Schlemm's canal cells are regulated by sheer stress (A), Wnt5a intervention by small interference RNAs (siRNAs) (B), or Wnt5a stimulation (C). (D and E) Summarized data showing that tube formation of human Schlemm's canal cells was inhibited by FZD5 siRNA (D) or ROR1 siRNA (E), respectively. Scrambled siRNA was used as negative control. *P<0.05. (F and G) Representative images showing that tube formation of human Schlemm's canal cells are regulated by the intervention of FZD5 (F) or ROR1 (G) via siRNAs. *P<0.05.

[0031] FIGS. 2A-C. (A-C, top panels) Real-time quantitative PCR data showing the expression levels of PLCB1, PPP3R1 and NFATC3 in human Schlemm's canal cells are regulated by sheer stress (A), Wnt5a intervention via siRNAs (B), or Wnt5a stimulation (C). (A-C, lower panels) Representative images and summarized data of Fluo-4 staining showing intracellular calcium signal is regulated by sheer stress (A), Wnt5a intervention via siRNAs (B), or Wnt5a stimulation (C). Green: Fluo-4, blue: DAPI nuclear staining *P<0.05.

[0032] FIGS. 3A-B. Real-time quantitative PCR data showing the expression of CAMK2D in human Schlemm's canal cells is regulated by sheer stress (A), or wnt5a stimulation (B), respectively. *P<0.05.

[0033] FIGS. 4A-I. Summarized data showing that tube formation of human Schlemm's canal cells were inhibited by the intervention of anti-ROR1 antibody (A), ROR1 small molecule inhibitor, DB03208 in 0.07% ethanol (B), FZD2 siRNA (C), anti-FZD2 antibody (D), anti-FZD5 antibody (E), CAMK2D siRNA (F), PLCB1 siRNA (CI), PPP3RI siRNA (II), or NFATC3 siRNA (I) in vitro, respectively. isotype control, vehicle control of ethanol (0.07%), or scrambled siRNA were used as negative controls for the antibody, DB03208 small molecule inhibitor, and siRNA treatment assays, respectively. *P<0.05.

[0034] FIGS. 5A-B. (A) ROR1 small molecule inhibitor. (B) ROR1 antibody inhibitor.

[0035] FIGS. 6A-B. (A) FZD5 antibody inhibitor. (B) FZD2 antibody inhibitor.

DESCRIPTION OF PARTICULAR EMBODIMENTS OF THE INVENTION

[0036] The examples and embodiments described herein are for illustrative purposes and various modifications or changes in light thereof will be apparent to persons skilled in the art and are to be included within this invention. Those skilled in the art will recognize a variety of noncritical parameters that could be changed or modified to yield essentially similar results. The invention may exclude or be practiced in the absence of any compound, component, element or step which is not disclosed are required herein. Unless contraindicated or noted otherwise, in these descriptions and throughout this specification, the terms “a” and “an” mean one or more. All publications, patents, and patent applications cited herein, including citations therein, are hereby incorporated by reference in their entirety for all purposes.

[0037] The disclosed Wnt5a receptor/effector inhibition methods can be genetic manipulation, and/or administrations of small interfering RNAs (siRNAs), antibodies, small molecules, etc., many of which are commercially available from sources like Applied Biological Materials Inc. (ABM, Richmond BC), Life Technologies (ThermoFisher Scientific), Sigma-Aldrich, etc. The methods can be used alone to lower intraocular pressure and to prevent or treat glaucoma, and/or in combination with other therapeutic approaches, such as eye drops, medications, laser, implanted devices, and surgery, etc. to prevent or treat glaucoma.

[0038] Prototypical Examples

[0039] Wnt5a Identification and Targeting

[0040] We disclosed Wnt5a identification and targeting in WO2019/040311.

[0041] Wnt5a is expressed on human primary SC cells in culture and mouse SC in vivo. Wnt5a expression is regulated with sheer stress change, as analyzed by quantitative real-time PCR assay. We also demonstrate that Wnt5a expression in human SC cells can be down-regulated by Wnt5a-specific siRNA, which affects SC cell functions as well. In SC-specific Wnt5a gene conditional knockout mice IOP elevation induced in a glaucoma model is significantly reduced compared to control littermates. No significant difference was found in baseline IOP between the knockout mice and control littermates. Compared with the control littermates that had IOP elevation at all time-points studied, Wnt5a knockout mice only showed elevated IOP at the early (within 24 hours) but not later time points, indicating an unsustainable IOP increase with Wnt5a intervention. We also demonstrate that wnt5a intervention is effective in protecting retinal nerve fiber layer and increasing SC permeability, a target for enhancement of aqueous movement through the conventional outflow system to manage ocular hypertension (e.g. Tam et al., Scientific Reports 7:40717, DOI: 10.1038/srep40717). These experiments demonstrate Wnt5a is an effective therapeutic target for glaucoma management. These results are further demonstrated by selective inhibition of Wnt5a by CRISPR gene editing employing the methods of Huang, et al. (Nature Communications, 2017; 8 (1) DOI: 10.1038/s41467-017-00140-3).

[0042] We next developed experimental protocols to demonstrate efficacy of Wnt5a siRNA inhibitor treatments to reduce IOP. For these protocols Wnt5a specific siRNA was obtained commercially (human WNTSA siRNA, Life Technologies; Anastas, et al. J. Clin. Investig. 2014, 124, 2877-2890). In one protocol subconjuctival injection of siRNA is performed as described by Yuen et al. (2014, Invest Ophthalmol Vis Sci. 2014;55:3320-3327). Mice are randomly selected to receive subconjunctival injection of 5 uL (0.2 lg/uL) siRNA or control twice a week for 2 weeks. In a second protocol intracameral injection of siRNA is performed as described by Tam et al. (2017, Scientific Reports 7, 40717). Mice are anaesthetized by intra-peritoneal injection, and pupils are dilated. A pulled blunt-ended micro-glass needle is first used to puncture the cornea to withdraw aqueous humour Immediately after puncture, a pulled blunt-ended micro-glass needle attached to a 10 μl syringe is inserted through the puncture, and 1.5 μl of PBS containing 1 μg siRNA is administered into the anterior chamber. Contralateral eyes receive an identical injection of 1.5 μl containing the same concentration of scrambled siRNA. These experiments demonstrate that Wnt5a-specific inhibitor siRNA delivered locally by either subconjuctival injection or intracameral injection is an effective therapy for pathogenic IOP.

[0043] To assess the effect of siRNA delivered by eye drops on IOP, we developed an additional protocol based on the methods of Martinez et al. (Mol Ther. 2014 January; 22(1):81-91), wherein New Zealand White rabbits receive a topical administration of either 20 nmol/day of siRNA or phosphate-buffered saline (PBS) over a period of 4 consecutive days. Treated eyes present a significant IOP decrease when compared with the vehicle-treated group. The effect of the siRNA on IOP is detectable 2 days after the first administration and values remains below basal levels until ˜2 days after the last administration. We also adapted an oral water overloading model in New Zealand White Rabbits to evaluate the IOP-lowering effect of Wnt5a siRNA in pathologic conditions like observed in glaucoma. Initially four different doses of siRNA (10 nmol, 20 nmol, 40 nmol, and 60 nmol/eye/day) are administered a total of three times: 48, 24, and 2 hours before hypertension induction. All treatments are applied in both eyes and IOP measured before hypertension induction and every 20 minutes up to 120 minutes after oral overloading. Analysis of the results shows that the Wnt5a siRNA provides significant protection against the rise of IOP at all doses tested.

[0044] To confirm the efficacy and specificity of Wnt5a siRNA on IOP, a larger group of animals is treated with a dose of 40 nmol/eye/day over a period of 4 consecutive days; on the fourth day, ocular hypertension is induced by water loading. Control results demonstrate that water loading caused an increase in IOP during the first hour after hypertension induction in animals treated with PBS. Analysis performed by comparing IOP values at each time point indicate that treatment with siRNA significantly reduced ΔIOP values within the first hour compared with PBS-treated animals. The effect is specific since treatment with a scrambled sequence siRNA has no effect on IOP.

[0045] We next developed experimental protocols to demonstrate efficacy of Wnt5a specific antibody inhibitor treatments to reduce IOP. These protocols employ two different antibodies: anti-human WNTSA antibody produced in rabbit purified immunoglobulin, buffered aqueous solution (Sigma-Aldrich SAB1411396), and an anti-human WNTSA monoclonal antibody produced in mouse clone 6F2, ascites fluid (Sigma-Aldrich SAB5300183), although other Wnt5a antibodies can be used, e.g. Hanaki et al., Mol Cancer Ther 11(2) February 2012; He et al. Oncogene. 2005, 24 (18): 3054-3058. Using both the mouse and rabbit models (supra), these experiments demonstrate that Wnt5a-specific antibody inhibitor delivered locally by eye drops is an effective therapy for pathogenic IOP.

[0046] In an exemplary model system intraocular hypertension was induced in the right eye (OD) of wildtype normal mice and Wnt5a neutralizing antibodies were administered to assess their therapeutic effects on IOP and other parameters of glaucoma including corneal edema, retinal ganglion cell (RGC) death, and RNFL thinning Compared to the control group where IOP was significantly elevated in the right eyes of the mice, IOP in Wnt5a antibody treated eyes was significantly lower and maintained at the baseline level. Wnt5a intervention reduced corneal edema, as measured by central corneal thickness in vivo by OCT. Increased corneal thickness was observed in the control group after IOP was increased, but not in Wnt5a antibody treated eyes. Wnt5a intervention reduced RGC death as well as RNFL thinning in the treated eyes. These were detected by immunostaining and OCT, respectively. These results confirmed that local Wnt5a antibody intervention significantly lowers IOP and protects the cornea and retina in a mouse model of glaucoma.

[0047] We next designed experimental protocols to demonstrate efficacy of Wnt5a specific antagonist peptide and small molecule inhibitor treatments to reduce IOP. These protocols employ a t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide (Box5) that functions as a potent antagonist of Wnt5a (Jenei, et la., PNAS USA, 106 (46), 19473-8), and 6,7-dihydro -10alpha-hydroxy radicicol, a potent WNT-5A expression inhibitor with relatively low toxicity and excellent stability (Shinonaga et al. Bioorg Med Chem. 2009 Jul. 1; 17(13):4622-35). Again using both the mouse and rabbit models (supra), these experiments demonstrate that Wnt5a-specific modified peptide inhibitor and small molecule inhibitor of Wnt5a expression, delivered locally by eye drops are effective therapies for pathogenic IOP.

[0048] Downstream Effector Identification and Targeting

[0049] We next demonstrated that FZD5 (frizzled-5), FZD2 and ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1), are expressed on SC, their expression is regulated in response to sheer stress change, Wnt5a stimulation or intervention. Moreover, their modulation can regulate SC function, such as tube formation. In particular, in SC cells cultured under pressure (or increased sheer stress), we observed increase of Wnt5a, and Fzd5, Fzd2, RoR1, when Wnt5a is down regulated, Fzd5, Fzd2 and ROR1 are downregulated as well, and when we stimulated human SC cells with Wnt5a, Fzd5, Fzd2 and ROR1 increased correspondingly. See, FIG. 1.

[0050] Additionally, we demonstrated that calcium signaling is involved in SC function, and several related molecules, such as PLCB1 (phospholipase C, beta 1), PPP3R1 (Protein Phosphatase 3 Regulatory Subunit B, Alpha), NFATC3 (Nuclear Factor of Activated T Cells 3), CAMK2D (Calcium/Calmodulin Dependent Protein Kinase II Delta), are regulated in response to sheer stress change, Wnt5a stimulation or intervention. See, FIGS. 2 and 3.

[0051] We disclose that these Wnt receptors (i.e. FZD5, FZD2, ROR1) and related molecules of calcium signaling pathways (i.e. PLCB1, PPP3R1, NFATC3, CAMK2D) provide targets to modulate SC function and treat glaucoma.

[0052] We next developed experimental protocols to demonstrate efficacy of Wnt5a receptor siRNA inhibitor treatments to reduce IOP. For these protocols FZD5, FZD2 and ROR1 specific siRNA was obtained commercially (e.g. ThermoFisher Scientific). In one protocol subconjuctival injection of siRNA is performed as described by Yuen et al. (2014, Invest Ophthalmol Vis Sci. 2014; 55:3320-3327). Mice are randomly selected to receive subconjunctival injection of 5 uL (0.2 lg/uL) FZD5 siRNA, FZD2 siRNA, or ROR1 siRNA or control twice a week for 2 weeks. In a second protocol intracameral injection of FZD5 siRNA, FZD2 siRNA or ROR1 siRNA is performed as described by Tam et al. (2017, Scientific Reports 7, 40717). Mice are anaesthetized by intra-peritoneal injection, and pupils are dilated. A pulled blunt-ended micro-glass needle is first used to puncture the cornea to withdraw aqueous humour. Immediately after puncture, a pulled blunt-ended micro-glass needle attached to a 10 μl syringe is inserted through the puncture, and 1.5 μl of PBS containing 1 μg siRNA is administered into the anterior chamber. Contralateral eyes receive an identical injection of 1.5 μl containing the same concentration of scrambled siRNA. These experiments demonstrate that FZD5, FZD2 and ROR1-specific inhibitor siRNA delivered locally by either subconjuctival injection or intracameral injection is an effective therapy for pathogenic IOP.

[0053] To assess the effect of siRNA delivered by eye drops on IOP, we developed an additional protocol based on the methods of Martinez et al. (Mol Ther. 2014 January; 22(1):81-91), wherein New Zealand White rabbits receive a topical administration of either 20 nmol/day of FZD5 siRNA or FZD2 siRNA or ROR1 siRNA or phosphate-buffered saline (PBS) over a period of 4 consecutive days. Treated eyes present a significant IOP decrease when compared with the vehicle-treated group. The effect of the FZD5 siRNA, FZD2 siRNA and ROR1 siRNA on IOP is detectable 2 days after the first administration and values remains below basal levels until 2 days after the last administration. We also adapted an oral water overloading model in New Zealand White Rabbits to evaluate the IOP-lowering effect of FZD5 siRNA, FZD2 siRNA and ROR1 siRNA in pathologic conditions like observed in glaucoma. Initially four different doses of each siRNA (10 nmol, 20 nmol, 40 nmol, and 60 nmol/eye/day) are administered a total of three times: 48, 24, and 2 hours before hypertension induction. All treatments are applied in both eyes and IOP measured before hypertension induction and every 20 minutes up to 120 minutes after oral overloading. Analysis of the results shows that the FZD5 siRNA, FZD2 siRNA and ROR1 siRNA provide significant protection against the rise of IOP at all doses tested.

[0054] To confirm the efficacy and specificity of FZD5 siRNA, FZD2 siRNA and ROR1 siRNA on IOP, a larger group of animals is treated with a dose of 40 nmol/eye/day over a period of 4 consecutive days; on the fourth day, ocular hypertension is induced by water loading. Control results demonstrate that water loading caused an increase in IOP during the first hour after hypertension induction in animals treated with PBS. Analysis performed by comparing IOP values at each time point indicate that treatment with FZD5 siRNA, FZD2 siRNA or ROR1 siRNA significantly reduced ΔIOP values within the first hour compared with PBS-treated animals. The effect is specific since treatment with a scrambled sequence siRNA has no effect on IOP.

[0055] We next developed experimental protocols to demonstrate efficacy of FZD5, FZD2 and ROR1 specific antibody inhibitor treatments to reduce IOP. These protocols employed OMP18R5 (a humanized monoclonal antibody that binds FZD5), Abcam ab52565 (a monoclonal antibody that binds FZD2), and cirmtuzumab (a humanized IgG1 anti-ROR1 monoclonal antibody), though an anti-human FZD5, FZD2 siRNA and ROR1 polyclonal and monoclonal antibodies, are commercially available from multiple sources, e.g. ThermoFisher Scientific, Abcam, SigmaAldrich, etc.); see also U.S. Pat. No. 9,573,998 for antibodies against human FZD5. Using both the mouse and rabbit models (supra), these experiments demonstrate that FZD5, FZD2 siRNA and ROR1-specific antibody inhibitor delivered locally by eye drops is an effective therapy for pathogenic IOP.

[0056] In an exemplary model system intraocular hypertension was induced in the right eye (OD) of wildtype normal mice and FZD5, FZD2 or ROR1 neutralizing antibodies are administered to assess their therapeutic effects on IOP and other parameters of glaucoma including corneal edema, retinal ganglion cell (RGC) death, and RNFL thinning Compared to the control group where IOP is significantly elevated in the right eyes of the mice, IOP in FZD5, FZD2 and ROR1 antibody treated eyes is significantly lower. FZD5, FZD2 and ROR1 intervention reduces corneal edema, as measured by central corneal thickness in vivo by OCT. Increased corneal thickness was observed in the control group after IOP was increased, but not in FZD5, FZD2 and ROR1 antibody treated eyes. FZD5, FZD2 and ROR1 intervention reduced RGC death as well as RNFL thinning in the treated eyes. These are detectable by immunostaining and/or OCT, respectively. These results confirmed that local FZD5, FZD2 and ROR1 antibody intervention significantly lowers IOP and protects the cornea and retina in a mouse model of glaucoma.

[0057] We next designed experimental protocols to demonstrate efficacy of FZD5, FZD2 and ROR1 specific antagonist peptides and small molecule inhibitor treatments to reduce IOP. These protocols employ a mutant FZD5 fragment that function as a potent antagonists (e.g. Liu et al., Hum Mol Genet. 2016 Apr. 1; 25(7): 1382-1391 and an oral small molecule inhibitor of ROR1 (KAN0439834; Hojjat-Farsangi et al., Leukemia 32, p2291-2295, 2018). Again using both the mouse and rabbit models (supra), these experiments demonstrate that FZD5, FZD2 and ROR1-specific modified peptide inhibitor and small molecule inhibitors delivered locally by eye drops are effective therapies for pathogenic IOP.

[0058] In exemplary models vivo data were obtained using well-established mouse model of glaucoma with laser-induced occlusion of episcleral veins (Zhang L, et al. Establishment and Characterization of an Acute Model of Ocular Hypertension by Laser-Induced Occlusion of Episcleral Veins. Invest Ophthalmol Vis Sci. 2017 Aug. 1; 58(10):3879-3886). Intraocular hypertension is introduced in the right eyes (OD) of the mice with the left eyes (OS) as controls. In these examples, the inhibitors or their controls were delivered daily to the right eyes via local administration of subconjunctival injection, starting from Day 1 after the induction of intraocular hypertension in the right eyes of the mice. Left eyes were used as controls. Central corneal thickness and RNFL were measured on Day 3 or Day 7 by in vivo OCT, respectively. All in vitro data were collected from human Schlemm's cells in culture.

[0059] ROR1 Inhibitors

[0060] 1) Cirmtuzumab

[0061] 2) KAN0439834, ; Hojjat-Farsang et al., Leukemia. 2018 October; 32(10):2291-2295. doi: 10.1038/s41375-018-0113-1; see also class of related inhibitors: 2-phenyl-3H-imidazo[4,5-b]pyridines (US2018/0002329; U.S. Pat. No. 10,550,113), see below, and incorporated by reference herein.

[0062] 3) ROR1 siRNAs, Thermofisher

[0063] 4) ROR1 antibody, R&D Systems, Cat # AF2000

[0064] 5) ROR1 small molecule, Beta-1,2,3,4,6-Penta-O-Galloyl-D-Glucopyranose (DB03208), Medkoo Biosciences, Inc. Cat #: 564580

##STR00001##

[0065] 6) ROR1 small molecule, 3-O-galloyl-4,6-[(S)-hexahydroxydiphenoyl]-b-d-glucopyranose (strictinin); see: Fultang N, et al. Strictinin, a novel ROR1-inhibitor, represses triple negative breast cancer survival and migration via modulation of PI3K/AKT/GSK3β activity. PLoS One. 2019 May 31; 14(5):e0217789.

[0066] 7) ROR1 blocking peptide; see: https://www.mybiosource.com/blocking-peptide/ror1/544396

[0067] 8) (R)-5,7-bis(methoxymethoxy)-2-(4-methoxyphenyl)chroman-4-one (ARI-1), defined as a ROR1 inhibitor; see: Liu X. et al. Novel ROR1 inhibitor ARI-1 suppresses the development of non-small cell lung cancer. Cancer Lett. 2019 August 28; 458:76-85.

[0068] 9) ROR1-cFab (a chimeric anti-ROR1 Fab antibody); see: Yin Z. et al. Antitumor activity of newly developed monoclonal antibody against ROR1 in ovarian cancer cells. Oncotarget. 2017 Oct. 7; 8(55):94210-94222).

[0069] FZD2 Inhibitors

[0070] FZD2 siRNAs, Thermofisher

[0071] FZD2 antibody, Abcam ab52565

[0072] FZD5 Inhibitors

[0073] FZD5 siRNAs, Thermofisher

[0074] FZD5 antibody, R&D Systems AF1617

[0075] CAMK2D Inhibitors

[0076] CAMK2D siRNA, Thermofisher

[0077] PLCB1 Inhibitors

[0078] PLCB1 siRNA, Thermofisher

[0079] PPP3R1 Inhibitors

[0080] PPP3R1 siRNA, Thermofisher

[0081] NFATC3 Inhibitors

[0082] 1) NFATC3 siRNA, Thermofisher

[0083] Recombinant antihuman antibody and variants:

[0084] 2) Creativebiolabs Recombinant-Anti-Human-NFATC3-Antibody-10188

[0085] 3) Creativebiolabs Rcombinant-Anti-Human-NFATC3-Antibody-Fab-Fragment-10189

[0086] 4) Creativebiolabs Rcombinant-Anti-Human-NFATC3-Antibody-scFv-Fragment-10190

TABLE-US-00001 TABLE  Human siRNA sequences Sequence Sequence  names Cat# AssayID (5′->3′) sense (5′->3′) antisense Wnt5a AM16708 121437 GGACCCGCUUAUUUAUAGAtt UCUAUAAAUAAGCGGGUCCtg (SEQ ID NO: 01) (SEQ ID NO: 02) ROR1 AM16708 143956 CCAUCCGCUGGUUCAAAAAtt UUUUUGAACCAGCGGAUGGtg (SEQ ID NO: 03) (SEQ ID NO: 04) FZD5 AM16708 139070 CGUGUAUUCUAUUUUGCGUtt ACGCAAAAUAGAAUACACGtg (SEQ ID NO: 05) (SEQ ID NO: 06) FZD2 AM16708 144688 CGUACUUGGUAGACAUGCAtt UGCAUGUCUACCAAGUACGtg (SEQ ID NO: 07) (SEQ ID NO: 08) CAMK2D AM16708 118255 CCAAAAAGCUUUCUGCUAGtt CUAGCAGAAAGCUUUUUGGtg (SEQ ID NO: 09) (SEQ ID NO: 10) PLCB1 AM16708 136825 CCUCGUGAACAUCUCCCAUtt AUGGGAGAUGUUCACGAGGtc (SEQ ID NO: 11) (SEQ ID NO: 12) PPP3R1 AM16708 104462 GGCUAGGAAAGAGAUUUAAtt UUAAAUCUCUUUCCUAGCCtt (SEQ ID NO: 13) (SEQ ID NO: 14) NFATC3 AM16708 105293 GGUGCACUUUUAUCUUUGCtt GCAAAGAUAAAAGUGCACCtg (SEQ ID NO: 15) (SEQ ID NO: 16) * ThermoFisher Scientific siRNA gene names

[0087] Table. KAN0439834 and related 2-phenyl-3H-imidazo[4,5-b]pyridine ROR1 inhibitors: see US2018/0002329; U.S. Pat. No. 10,550,113.

[0088] 1. 2-(4-{7-[(1-benzylpiperidin-4-yl)amino]-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-[2-(dimethylamino)ethyl]acetamide

[0089] 2. 2-[4-(7-{[(3S)-1-benzylpyrrolidin-3-yl]amino}-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-[2-(dimethylamino)ethyl]acetamide

[0090] 3. 2-[4-(6-chloro-7-{[1-(2-phenylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-[2-(dimethylamino)ethyl]acetamide

[0091] 4. 2-[4-(7-{[(3S)-1-benzylpyrrolidin-3-yl]amino}-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-[2-(dimethylamino)-1,1-dimethylethyl]acetamide

[0092] 5. 2-(4-{7-[(1-benzylpiperidin-4-yl)amino]-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-[2-(dimethylamino)-1,1-dimethylethyl]acetamide

[0093] 6. 2-[4-(6-chloro-7-{[1-(4-fluorobenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-[2-(dimethylamino)-1,1-dimethylethyl]acetamide

[0094] 7. 2-(4-{7-[(1-benzylpiperidin-3-yl)amino]-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-[2-(dimethylamino)-1,1-dimethylethyl]acetamide

[0095] 8. 2-{4-[6-chloro-7-({1-[(3-methyl-2-thienyl)methyl]piperidin-4-yl}amino)-3H -imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-[2-(dimethylamino)-1,1-dimethylethyl]acetamide

[0096] 9. 2-[4-(6-chloro-7-{[1-(3-methylbenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-[2-(dimethylamino)ethyl]acetamide

[0097] 10. 2-[4-(6-chloro-7-{[1-(4-methylbenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-[2-(dimethylamino)ethyl]acetamide

[0098] 11. 2-(4-{7-[(1-benzylpiperidin-4-yl)amino]-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-methylacetamide

[0099] 12. 2-[4-(7-{[(3S)-1-benzylpyrrolidin-3-yl]amino}-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0100] 13. 2-[4-(7-{[1-(1,3-benzodioxol-5-ylmethyl)piperidin-4-yl]amino}-6-chloro-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-[2-(dimethylamino)ethyl]acetamide

[0101] 14. 2-[4-(6-chloro-7-{[1-(1,3-thiazol-2-ylmethyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-[2-(dimethylamino)ethyl]acetamide

[0102] 15. 2-[4-(6-chloro-7-{[1-(thiophen-3-ylmethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-[2-(dimethylamino)ethyl]acetamide

[0103] 16. 2-[4-(7-{[(1-benzylpiperidin-4-yl)methyl]amino}-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-[2-(dimethylamino)ethyl]acetamide

[0104] 17. 2-(4-{7-[(1-benzylpiperidin-4-yl)(methyl)amino]-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-[2-(diethylamino)ethyl]acetamide

[0105] 18. 2-(4-{7-[(1-benzylpiperidin-4-yl)(methyl)amino]-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-[2-(dimethylamino)-2-methylpropyl]acetamide

[0106] 19. -(4-{7-[(1-benzylpiperidin-4-yl)(methyl)amino]-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-methylacetamide

[0107] 20. 2-(4-{7-[(1-benzylpiperidin-4-yl)(methyl)amino]-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-[2-(dimeethylamino)ethyl]acetamide

[0108] 21. 2-(4-{7-[(1-benzylpiperidin-4-yl)(methyl)amino]-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-[2-(dimethylamino)-1-methylethyl]acetamide

[0109] 22. 2-[4-(6-chloro-7-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-[2-(dimethylamino)ethyl]acetamide

[0110] 23. 2-(4-{7-[(1-benzylpiperidin-4-yl)amino]-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-[2-(dimethylamino)-2-methylpropyl]acetamide

[0111] 24. 2-[4-(7-{[(3R)-1-benzylpyrrolidin-3-yl]amino}-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-[2-(dimethylamino)-2-methylpropyl]acetamide

[0112] 25. 2-[4-(7-{[(3S)-1-benzylpyrrolidin-3-yl]amino}-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-[2-(dimethylamino)-2-methylpropyl]acetamide

[0113] 26. 2-[4-(6-chloro-7-{[1-(4-fluorobenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-[2-(dimethylamino)-2-methylpropyl]acetamide

[0114] 27. 2-[4-(6-chloro-7-{[1-(4-methylbenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-[2-(dimethylamino)-2-methylpropyl]acetamide

[0115] 28. 2-[4-(6-chloro-7-{[1-(3-methylbenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-[2-(dimethylamino)-2-methylpropyl]acetamide

[0116] 29. 2-{4-[6-chloro-7-({1-[(5-methylfuran-2-yl)methyl]piperidin-4-yl}amino)-3H -imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-[2-(dimethylamino)ethyl]acetamide

[0117] 30. 2-[4-(7-{[(3R)-1-benzylpyrrolidin-3-yl]amino}-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-[2-(dimethylamino)ethyl]acetamide

[0118] 31. 2-[4-(7-{[(1-benzylpiperidin-4-yl)methyl]amino}-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-[2-(dimeethylamino)-2-methylpropyl]acetamide

[0119] 32. 2-[4-(6-chloro-7-{[(3S)-1-(3,4-difluorobenzyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-[2-(dimethylamino)ethyl]acetamide

[0120] 33. 2-[4-(6-chloro-7-{[(3S)-1-(4-fluorobenzyl)pyrrolidin-3-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-[2-(dimethylamino)ethyl]acetamide

[0121] 34. 2-[4-(6-chloro-7-{[(3S)-1-(3,4-difluorobenzyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0122] 35. 2-[4-(6-chloro-7-{[(3S)-1-(4-fluorobenzyl)pyrrolidin-3-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0123] 36. 2-[4-(6-chloro-7-{[(3R)-1-(4-fluorobenzyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-[2-(dimethylamino)ethyl]acetamide

[0124] 37. 2-[4-(6-chloro-7-{[(3R)-1-(4-fluorobenzyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0125] 38. 2-[4-(7-{[(3R)-1-benzylpyrrolidin-3-yl]amino}-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0126] 39. 2-[4-(6-chloro-7-{[1-(thiophen-3-ylmethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-meethylacetamide

[0127] 40. 2-[4-(6-chloro-7-{[1-(3-methylbenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-methylacetamide

[0128] 41. 2-[4-(6-chloro-7-{[(3S)-1-(2-phenylethyl)pyrrolidin-3-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0129] 42. 2-{4-[6-chloro-7-({1-[(3-methyl-2-thienyl)methyl]piperidin-4-yl}amino)-3H -imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-methylacetamide

[0130] 43. 2-[4-(6-chloro-7-{[(3S)-1-(4-methoxybenzyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0131] 44. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-methylacetamide

[0132] 45. 2-[4-(7-{[(1,3-benzodioxol-5-ylmethyl)piperidin-4-yl]amino}-6-chloro-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0133] 46. 2-{4-[6-chloro-7-({1-[(5-methylfuran-2-yl)methyl]piperidin-4-yl}amino)-3H -imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-methylacetamide

[0134] 47. 2-[4-(6-chloro-7-{[(3S)-1-(thiophen-3-ylmethyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0135] 48. 2-[4-(6-chloro-7-{[1-(furan-3-ylmethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-methylacetamide

[0136] 49. 2-[4-(7-{[(3S)-1-(1,3-benzodioxol-5-ylmethyl)pyrrolidin-3-yl]amino}-6-chloro-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0137] 50. 2-[4-(6-chloro-7-{[(3S)-1-(1,3-thiazol-2-ylmethyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0138] 51. 2-{4-[6-chloro-7-({(3S)-1-[(3-methyl-2-thienyl)methyl]pyrrolidin-3-yl}amino)-3H -imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-methylacetamide

[0139] 52. 2-{4-[6-chloro-7-({(3S)-1-[4-(trifluoromethyl)benzyl]pyrrolidin-3-yl}amino)-3H -imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-methylacetamide

[0140] 53. 2-[4-(6-chloro-7-{[(3S)-1-(3-methylbenzyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0141] 54. 2-[4-(6-chloro-7-{[(3S)-1-(4-methylbenzyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0142] 55. 2-[4-(6-chloro-7-{[(3S)-1-(2-thienylmethyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0143] 56. 2-(4-{6-chloro-7-[(1-cyclohexylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-methylacetamide

[0144] 57. 2-[4-(6-chloro-7-{[(3S)-1-(3-methoxybenzyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0145] 58. 2-[4-(6-chloro-7-}[(3S)-1-(2-methoxybenzyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0146] 59. 2-[4-(6-chloro-7-{[(3S)-1-(2-methylbenzyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0147] 60. 2-[4-(6-chloro-7-{[1-(2,4-dimethoxybenzyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0148] 61. 2-[4-(6-chloro-7-{[1-(2-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-methylacetamide

[0149] 62. 2-[4-(6-chloro-7-{[1-(3-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-methylacetamide

[0150] 63. 2-(4-{7-[(1-benzylpiperidin-4-yl)amino]-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N,N-dimethylacetamide

[0151] 64. 2-[4-(7-{[(3S)-1-benzylpyrrolidin-3-yl]amino}-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N,N-dimethylacetamide

[0152] 65. 2-[4-(6-chloro-7-{[1-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0153] 66. 2-[4-(6-chloro-7-{[1-(cyclohexylmethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0154] 67. 2-[4-(6-chloro-7-{[1-(2,2-dimethylpropyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0155] 68. 2-[4-(6-chloro-7-1[1-(3-hydroxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-methylacetamide

[0156] 69. 2-{4-[6-chloro-7-({1-[4-(difluoromethoxy)benzyl]piperidin-4-yl}amino)-3H -imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-methylacetamide

[0157] 70. 2-[4-(6-chloro-7-{[1-(4-methoxy-3-methylbenzyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0158] 71. 2-[4-(6-chloro-7-{[1-(pyridin-4-ylmethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0159] 72. 2-[4-(6-chloro-7-{[1-(pyridin-3-ylmethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0160] 73. 2-{4-[6-chloro-7-({1-[(1-methyl-1H-pyrrol-2-yl)methyl]piperidin-4-yl}amino)-3H -imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-methylacetamide

[0161] 74. 2-{4-[6-chloro-7-({1-[(6-methylpyridin-2-yl)methyl]piperidin-4-yl}amino)-3H -imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-methylacetamide

[0162] 75. 2-[4-(7-{[1-(4-acetamidobenzyl)piperidin-4-yl]amino}-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0163] 76. 2-[4-(6-chloro-7-{[1-(1,3-thiazol-2-ylmethyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0164] 77. 2-[4-(6-chloro-7-{[1-(4-ethoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0165] 78. 2-[4-(6-chloro-7-{[1-(4-isopropoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0166] 79. 2-[4-(7-{[(1-benzylpiperidin-4-yl)methyl]amino}-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0167] 80. 2-[4-(6-chloro-7-{[1-(4-methoxy-3,5-dimethylbenzyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0168] 81. 2-[4-(6-chloro-7-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0169] 82. 2-[4-(6-chloro-7-{[1-(4-methylbeiizyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0170] 83. 2-[4-(6-chloro-7-{[1-(4-cyanobenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0171] 84. 2-[4-(6-chloro-7-{[1-(3-cyanobenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy ]-N-methylacetamide

[0172] 85. 2-[4-(6-chloro-7-{[1-(4-hydroxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0173] 86. 2-{4-[6-chloro-7-(piperidin-4-ylamino)-3H-imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-methylacetamide

[0174] 87. 2-[4-(6-chloro-7-{[1-(4-fluorobenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-methylacetamide

[0175] 88. 2-[4-(6-chloro-7-{[1-(3,4-difluorobenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0176] 89. 2-{4-[6-chloro-7-({1-[4-(dimethylamino)benzyl]piperidin-4-yl}amino)-3H -imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-methylacetamide

[0177] 90. 2-{4-[6-chloro-7-({1-[4-(methylsulfonyl)benzyl]piperidin-4-yl}amino)-3H -imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-methylacetamide

[0178] 91. 2-[4-(6-chloro-7-{[1-(2,3-dihydro-1-benzofuran-5-ylmethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0179] 92. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-methylacetamide

[0180] 93. 2-[4-(6-chloro-7-{[1-(2-thienylmethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-methylacetamide

[0181] 94. 2-[4-(6-chloro-7-{[1-(2-phenylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-methylacetamide

[0182] 95. 2-{4-[6-chloro-7-({1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}amino)-3H -imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-methylacetamide

[0183] 96. 2-[4-(6-chloro-7-{[1-(2-phenoxyethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-methylacetamide

[0184] 97. 2-[4-(6-chloro-7-{[1-(3,4-dimethoxybenzyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0185] 98. 2-[4-(6-chloro-7-{[1-(4-hydroxy-3-methoxybenzyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0186] 99. 2-{4-[6-chloro-7-({1-[4-(1H-1,2,4-triazol-1-yl)benzyl]piperidin-4-yl}amino)-3H -imidazo[4,5-b]pyridin-2-]phenoxy}-N-methylacetamide

[0187] 100. 2-{4-[6-chloro-7-({1-[4-(methylthio)benzyl]piperidin-4-yl}amino)-3H -imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-methylacetamide

[0188] 101. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-(2-hydroxyethyl)acetamide

[0189] 102. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-[2-(dimethylamino)ethyl]acetamide

[0190] 103. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)pipendin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-[2-(dimethylamino)-2-methylpropyl]acetamide

[0191] 104. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-isopropylacetamide

[0192] 105. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-(2-isopropoxyethyl)acetamide

[0193] 106. 3-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenyl]-N-methylpropanamide

[0194] 107. 3-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenyl]-N-[2-(dimethylamino)ethyl]propanamide

[0195] 108. 3-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenyl]-N-methoxypropanamide

[0196] 109. 2-(4-{6-chloro-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-methylacetamide

[0197] 110. 2-[4-(6-chloro-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-methylacetamide

[0198] 111. 2-[4-(6-bromo-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-methylacetamide

[0199] 112. 2-[4-(6-bromo-7-{[1-(2,3-dihydro-1-benzofuran-5-ylmethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-{V-methylacetamide

[0200] 113. 2-[4-(6-bromo-7-{[1-(thiophen-2-ylmethyl)piperidin-4-yl]amino}-3H -imidazo[4,5-/?]pyridin-2-yl)phenoxy]-N-methylacetamide

[0201] 114. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-methylacetamide

[0202] 115. 2-[4-(6-bromo-7-{[(3S)-1-(2-methoxybenzyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0203] 116. 2-[3-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-methylacetamide

[0204] 117. 2-(3-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-methylacetamide

[0205] 118. 2-[3-(6-chloro-7-{[1-(2,3-dihydro-1-benzofuran-5-ylmethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0206] 119. 2-[3-(6-chloro-7-{[1-(thiophen-2-ylmethyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0207] 120. 2-[3-(7-{[1-(1,3-benzodioxol-5-ylmethyl)piperidin-4-yl]amino}-6-chloro-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0208] 121. 2-[3-(6-chloro-7-{[1-(2-phenoxyethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0209] 122. 2-[3-(6-chloro-7-{[(3S)-1-(2-methoxybenzyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0210] 123. 2-[3-(7-{[(3S)-1-benzylpyrrolidin-3-yl]amino}-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0211] 124. 2-(4-{6-chloro-7-[(1-hexylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-methylacetamide

[0212] 125. 2-[4-(6-chloro-7-{[1-(2-methylpropyl)piperidin-4-yl]amino)-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0213] 126. 2-(4-{6-chloro-7-[(1-propylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-methylacetamide

[0214] 127. 2-(4-{6-chloro-7-[(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-methylacetamide

[0215] 128. 2-{3-[6-chloro-7-({1-[4-(1H-1,2,4-triazol-1-yl)benzyl]piperidin-4-yl}amino)-3H -imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-methylacetamide

[0216] 129. 2-[4-(6-chloro-7-{[(3S)-1-methylpyrrolidin-3-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0217] 130. 2-[3-(6-chloro-7-{[1-(3-thienylmethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0218] 131. 2-[3-(6-chloro-7-{[1-(3-hydroxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0219] 132. 2-[4-(6-chloro-7-{[(3S)-1-ethylpyrrolidin-3-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0220] 133. 2-[4-(6-chloro-7-{[(3S)-1-propylpyrrolidin-3-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0221] 134. 2-[4-(6-chloro-7-{[(3S)-1-(1-methylethyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methylacetamide

[0222] 135. 2-(4-(6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-ethylacetamide

[0223] 136. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-isopropylacetamide

[0224] 137. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-cyclopentylacetamide

[0225] 138. 2-(4-{6-bromo-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-methylacetamide

[0226] 139. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-methoxyacetamide

[0227] 140. 2-(4-{6-bromo-7-[(1-propylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-methylacetamide

[0228] 141. 2-[4-(6-bromo-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-methylacetamide

[0229] 142. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(2-isopropoxyethyl)acetamide

[0230] 143. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-[2-(dimethylamino)ethyl]acetamide

[0231] 144. 2-[4-(6-bromo-7-{[(3S)-1-methylpyrrolidin-3-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-methylacetamide

[0232] 145. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(2-cyclohexylethyl)acetamide

[0233] 146. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(cyclohexylmethyl)acetamide

[0234] 147. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-[2-(tetrahydro-2H-pyran-4-yl)ethyl]acetamide

[0235] 148. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(tetrahydro-2H-pyran-4-ylmethyl)acetamide

[0236] 149. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-[2-(1-methylpiperidin-4-yl)ethyl]acetamide bis(trifluoroacetate)

[0237] 150. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-[(1-methylpiperidin-4-yl)methyl]acetamide

[0238] 151. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(piperidin-4-ylmethyl)acetamide

[0239] 152. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(2-morpholin-4-ylethyl)acetamide

[0240] 153. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(3-morpholin-4-ylpropyl)acetamide

[0241] 154. 2-[4-(6-chloro-7-{[1-(2-methoxyethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-methylacetamide

[0242] 155. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(2-piperidin-4-ylethyl)acetamide

[0243] 156. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-3-methylphenoxy)-N-methylacetamide

[0244] 157. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)-3-methylphenoxy]-N-methylacetamide

[0245] 158. 2-(4-{6-bromo-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-3-methylphenoxy)-N-methylacetamide

[0246] 159. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-3-methylphenoxy)-N-methylacetamide

[0247] 160. 2-[4-(6-bromo-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)-3-methylphenoxy]-N-methylacetamide

[0248] 161. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)-2-methylphenoxy]-N-methylacetamide

[0249] 162. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-methylphenoxy)-N-methylacetamide

[0250] 163. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-methylphenoxy)-N-methylacetamide

[0251] 164. 2-(4-{6-bromo-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-methylphenoxy)-N-methylacetamide

[0252] 165. 2-(4-{6-bromo-7-[(1-propylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-methylphenoxy)-N-methylacetamide

[0253] 166. 2-[4-(6-chloro-7-{[(3S)-1-(1-methylethyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)-2-methylphenoxy]-N-methylacetamide

[0254] 167. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-methoxyphenoxy)-N-methylacetamide

[0255] 168. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-methoxyphenoxy)-N-methylacetamide

[0256] 169. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)-2-methoxyphenoxy]-N-methylacetamide

[0257] 170. 2-(4-{6-bromo-7-[(1-propylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-methoxyphenoxy)-N-methylacetamide

[0258] 171. 2-[4-(6-chloro-7-{[(3S)-1-(1-methylethyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)-2-methoxyphenoxy]N-methylacetamide

[0259] 172. 2-[4-(6-chloro-7-{[1-(2,3-dihydro-1-benzofuran-5-ylmethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)-3-methylphenoxy]-N-methylacetamide

[0260] 173. 2-(4-{6-chloro-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-3-methylphenoxy)-N-methylacetamide

[0261] 174. 2-[4-(6-chloro-7-{[1-(thiophen-3-ylmethyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)-3-methylphenoxy]-N-methylacetamide

[0262] 175. 2-[4-(6-chloro-7-{[(3S)-1-(2-methoxybenzyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)-2-methylphenoxy]-N-methylacetamide

[0263] 176. 2-[4-(6-chloro-7-{[1-(thiophen-3-ylmethyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)-2-methylphenoxy]-N-methylacetamide

[0264] 177. 2-(4-{6-chloro-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-methylphenoxy)-N-methylacetamide

[0265] 178. 2-[4-(6-chloro-7-{[1-(2-methoxyethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)-2-methylphenoxy]-N-methylacetamide

[0266] 179. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N,2-dimethylpropanamide

[0267] 180. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N,2-dimethylpropanamide

[0268] 181. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N,2-dimethylpropanamide

[0269] 182. 2-(4-{6-bromo-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N,2dimethylpropanamide

[0270] 183. 2-[4-(6-chloro-7-{[(3S)-1-(1-methylethyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N,2-dimethylpropanamide

[0271] 184. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-fluorophenoxy)-N-methylacetamide

[0272] 185. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-fluorophenoxy)-N-methylacetamide

[0273] 186. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)-2-fluorophenoxy]-N-methylacetamide

[0274] 187. 2-(4-{6-bromo-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-fluorophenoxy)-N-methylacetamide

[0275] 188. 2-[4-(6-chloro-7-{[(3S)-1-ethylpyrrolidin-3-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)-2-fluorophenoxy]-N-methylacetamide

[0276] 189. 3-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N-methylpropanamide

[0277] 190. 3-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N-methylpropanamide

[0278] 191. 3-[4-(6-bromo-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenyl]-N-methylpropanamide

[0279] 192. 3-(4-{6-bromo-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N-methylpropanamide

[0280] 193. 3-[4(6-chloro-7-{[(3S)-1-ethylpyrrolidin-3-yl{amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenyl]-N-methylpropanamide

[0281] 194. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)-2,6-dimethylphenoxy]-N-methylacetamide

[0282] 195. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2,6-dimethylphenoxy)-N-methylacetamide

[0283] 196. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2,6-dimethylphenoxy)-N-methylacetamide

[0284] 197. 2-[4-(6-bromo-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)-2,6-dimethylphenoxy]-N-methylacetamide

[0285] 198. 2-[4-(6-chloro-7-{[(3S)-1-(1-methylethyl)pyrrolidin-3-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)-2,6-dimethylphenoxy]-N-methylacetamide

[0286] 199. 2-[4-(6-bromo-7-{[1-(thiophen-2-ylmethyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)-2,6-dimethylphenoxy]-N-methylacetamide

[0287] 200. 2-[4-(6-chloro-7-{[(3S)-1-ethylpyrrolidin-3-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)-2,6-dimethylphenoxy]-N-methylacetamide

[0288] 201. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)-2,5-dimethylphenoxy]-{V-methylacetamide

[0289] 202. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2,5-dimethylphenoxy)-N-methylacetamide

[0290] 203. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2,5-dimethylphenoxy)-N-methylacetamide

[0291] 204. 2-(4-{6-chloro-7-[(1-propylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2,5-dimethylphenoxy)-ALmethylacetamide

[0292] 205. 2-(4-{6-chloro-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2,5-dimethylphenoxy)-N-methylacetamide

[0293] 206. 2-(4-{6-chloro-7-[(1-propylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-methylphenoxy)-N-methylacetamide

[0294] 207. 2-(4-{6-chloro-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2,6-dimethylphenoxy)-N-methylacetamide

[0295] 208. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(4-methylcyclohexyl)acetamide

[0296] 209. N-tert-butyl-2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)acetamide

[0297] 210. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(1,1-dimethylpropyl)acetamide

[0298] 211. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-cyclohexylacetamide

[0299] 212. 3-(4-{6-chloro-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N-methylpropanamide

[0300] 213. 3-[4-(6-chloro-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenyl]-N-methylpropanamide

[0301] 214. 2-(4-{6-chloro-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-fluorophenoxy)-N-methylacetamide

[0302] 215. 2-[4-(6-chloro-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)-2-fluorophenoxy]-N-methylacetamide

[0303] 216. 2-(4-{6-chloro-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N,2-dimethylpropanamide

[0304] 217. 2-[4-(6-chloro-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N,2-dimethylpropanamide

[0305] 218. 2-(4-{6-chloro-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-methoxyphenoxy)-N-methylacetamide

[0306] 219. 2-[4-(6-chloro-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)-2-methoxyphenoxy]-N-methylacetamide

[0307] 220. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-propylacetamide

[0308] 221. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(2-methylpropyl)acetamide

[0309] 222. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(tetrahydrofuran-2-ylmethyl)acetamide

[0310] 223. 2-(4-(6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-[1-(methoxymethyl)propyl]acetamide

[0311] 224. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(2-methoxy-1-methylethyl)acetamide

[0312] 225. N-benzyl-2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-6]pyridin-2-yl}phenoxy)acetamide

[0313] 226. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(1-phenylethyl)acetamide

[0314] 227. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-cycloheptylacetamide

[0315] 228. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-fluorophenoxy)-N-(1-methylethyl)acetamide

[0316] 229. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-fluorophenoxy)-N-(1-methylethyl)acetamide

[0317] 230. 2-(4-{6-chloro-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}-2-fluorophenoxy)-N-(1-methylethyl)acetamide

[0318] 231. 2-[4-(6-chloro-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)-2-fluorophenoxy]-N-(1-methylethyl)acetamide

[0319] 232. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N-methylacetamide

[0320] 233. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenyl]-N-methylacetamide

[0321] 234. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-cyclopentylacetamide

[0322] 235. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-(cyclohexylmethyl)acetamide

[0323] 236. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-cycloheptylacetamide

[0324] 237. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-(2-cyclohexylethyl)acetamide

[0325] 238. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-[2-(tetrahydro-2H-pyran-4-yl)ethyl]acetamide

[0326] 239. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(4-methoxybenzyl)acetamide

[0327] 240. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(furan-2-ylmethyl)acetamide

[0328] 241. 2-(4-(6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(thiophen-2-ylmethyl)acetamide

[0329] 242. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(2-methoxyethyl)acetamide

[0330] 243. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-pyridin-4-ylacetamide

[0331] 244. 2-(4-{6-chloro-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N-methylacetamide

[0332] 245. 2-[4-(6-chloro-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenyl]-N-methylacetamide

[0333] 246. 2-(4-{6-chloro-7-[(1-propylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N-methylacetamide

[0334] 247. 2-(4-{6-bromo-7-[(1-propylpiperidin-4-yl)amino]3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N-methylacetamide

[0335] 248. 2-[4-(6-bromo-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenyl]-N-methylacetamide

[0336] 249. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N-methylacetamide

[0337] 250. 2-[4-(6-chloro-7-{[1-(thiophen-2-ylmethyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-cyclopentylacetamide

[0338] 251. 2-[4-(6-chloro-7-{[1-(thiophen-2-ylmethyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-cyclohexylacetamide

[0339] 252. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(1-methylethyl)acetamide

[0340] 253. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-propylacetamide

[0341] 254. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-[1-(methoxymethyl)propyl]acetamide

[0342] 255. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(2-methylpropyl)acetamide

[0343] 256. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-tert-butylacetamide

[0344] 257. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(1,1-dimethylpropyl)acetamide

[0345] 258. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-cyclohexylacetamide

[0346] 259. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-cyclopentyl acetamide

[0347] 260. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-ethylacetamide

[0348] 261. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(tetrahydro-2H-thiopyran-4-yl)acetamide

[0349] 262. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(tetrahydro-2H-pyran-4-yl)acetamide

[0350] 263. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(2,2,2-trifluoroethyl)acetamide

[0351] 264. N-{2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]ethyl}acetamide

[0352] 265. N-[2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)ethyl]acetamide

[0353] 266. N-[2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)ethyl]acetamide

[0354] 267. N-{2-[4-(6-chloro-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]ethyl}acetamide

[0355] 268. N-[2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)ethyl]cyclohexanecarboxamide

[0356] 269. N-[2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)ethyl]-2,2-dimethylpropanamide

[0357] 270. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-pyridin-4-ylacetamide

[0358] 271. 2-[4-(6-chloro-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-cyclohexylacetamide

[0359] 272. N-[2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)ethyl]pyridine-4-carboxamide

[0360] 273. N-[2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)ethyl]pyridine-3-carboxamide

[0361] 274. N-[2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)ethyl]-2-methoxyacetamide

[0362] 275. N-[2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)ethyl]cyclopentanecarboxamide

[0363] 276. N-[2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)ethyl]-2-methylpropanamide

[0364] 277. N-[2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)ethyl]cyclopropanecarboxamide

[0365] 278. N-[2-(4-(6-chloro-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)ethyl]acetamide

[0366] 279. N-{2-[4-(6-chloro-7-{[1-(thiophen-2-ylmethyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]ethyl}acetamide

[0367] 280. N-{2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl(phenoxy]ethyl}propanamide

[0368] 281. N-{2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]ethyl}cyclopentanecarboxamide

[0369] 282. N-{2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo [4,5-b]pyridin-2-yl)phenoxy]ethyl}-2-methylpropanamide

[0370] 283. N-{2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]ethyl}pyridine-4-carboxamide

[0371] 284. 2-{4-[6-Bromo-7-({1-[4-(1H-1,2,4-triazol-1-yl)benzyl]piperidin-4-yl}amino)-3H -imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-methylacetamide

[0372] 285. N-(2-{4-[6-chloro-7-({1-[4-(1H-1,2,4-triazol-1-yl)benzyl]piperidin-4-yl}amino)-3H-imidazo[4,5-b]pyridin-2-yl]phenoxy}ethyl)acetamide

[0373] 286. N-(2-{4-[6-bromo-7-({1-[4-(1H-1,2,4-triazol-1-yl)benzyl]piperidin-4-yl}amino)-3H-imidazo[4,5-b]pyridin-2-yl]phenoxy}ethyl)acetamide

[0374] 287. 2-{4-[6-chloro-7-({1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl}amino)-3H-imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-methylacetamide

[0375] 288. 2-{4-[6-bromo-7-({1-[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]piperidin-4-yl}amino)-3H-imidazo[4,5-b]pyridin-2-yl]phenoxy}-N-methylacetamide

[0376] 289. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-pyridin-3-ylacetamide

[0377] 290. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-(1-methyl-1H-pyrazol-5-yl)acetamide

[0378] 291. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-pyridin-3-ylacetamide

[0379] 292. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-pyrazin-2-ylacetamide

[0380] 293. N2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N-methylglycinamide

[0381] 294. N2-(4-(6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N-methylglycinamide

[0382] 295. N2-[4-(6-chloro-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenyl]-N-methylglycinamide

[0383] 296. N2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenyl]-N-methylglycinamide

[0384] 297. N2-(4-{6-chloro-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N-methylglycinamide

[0385] 298. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-pyridin-2-ylacetamide

[0386] 299. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-isoxazol-3-ylacetamide

[0387] 300. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(pyridin-4-ylmethyl)acetamide

[0388] 301. N3-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N-methyl-b-alaninamide

[0389] 302. N3-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N-methyl-b-alaninamide

[0390] 303. N3-[4-(6-chloro-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenyl]-N-methyl-b-alaninamide

[0391] 304. N3-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenyl]-N-methyl-b-alaninamide

[0392] 305. N3-(4-{6-chloro-7-[(1-ethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N-methyl-b-alaninamide

[0393] 306. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-(pyridin-4-ylmethyl)acetamide

[0394] 307. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-pyrimidin-2-ylacetamide

[0395] 308. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-pyrimidin-2-ylacetamide

[0396] 309. 2-[4-(6-chloro-7-{[1-(thiophen-2-ylmethyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-pyrimidin-2-ylacetamide

[0397] 310. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-pyrazin-2-ylacetamide

[0398] 311. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-pyrazin-2-ylacetamide

[0399] 312. 2-[4-(6-chloro-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-pyrazin-2-ylacetamide

[0400] 313. 2-[4-(6-chloro-7-{[1-(thiophen-3-ylmethyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-pyrazin-2-ylacetamide

[0401] 314. 2-[4-(6-chloro-7-{[1-(2,3-dihydro-1-benzofuran-5-ylmethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-pyrazin-2-ylacetamide

[0402] 315. 2-(4-{5-chloro-4-[(1-methylpiperidin-4-yl)amino]-1H-pyrrolo [2,3-b]pyridin-2-yl}phenoxy)-N-(5-methylisoxazol-3-yl)acetamide

[0403] 316. N2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenyl)-N2-methyl-N-pyridin-3-ylglycinamide

[0404] 317. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(5-chloropyridin-3-yl)acetamide

[0405] 318. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-isoxazol-3-ylacetamide

[0406] 319. 2-(4-{6-bromo-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-isoxazol-3-ylacetamide

[0407] 320. 2-[4-(6-chloro-7-{[1-(1-methylethyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-isoxazol-3-ylacetamide

[0408] 321. 2-[4-(6-chloro-7-{[1-(thiophen-3-ylmethyl)piperidin-4-yl]amino}-3H -imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-isoxazol-3-ylacetamide

[0409] 322. 2-(4-{6-chloro-7-[(1-propylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-isoxazol-3-ylacetamide

[0410] 323. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-pyrazin-2-ylacetamide

[0411] 324. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(1-methyl-1H-pyrazol-5-yl)acetamide

[0412] 325. 2-[4-(6-chloro-7-{[1-(4-methoxybenzyl)piperidin-4-yl]amino}-3H-imidazo[4,5-b]pyridin-2-yl(phenoxy]-N-1H-1,2,4-triazol-3-ylacetamide

[0413] 326. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-1H-1,2,4-triazol-3-ylacetamide

[0414] 327. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-1,3,4-thiadiazol-2-ylacetamide

[0415] 328. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-(3-methylisoxazol-5-yl)acetamide

[0416] 329. 2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-1,3-thiazol-2-ylacetamide

[0417] 330. N-(5-tert-butylisoxazol-3-yl)-2-(4-{6-chloro-7-[(1-methylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)acetamide

[0418] 331. 2-(4-{6-chloro-7-[(1-niethylpiperidin-4-yl)amino]-3H-imidazo[4,5-b]pyridin-2-yl}phenoxy)-N-pyrimidin-5-ylacetamide

[0419] Preferred 2-phenyl-3H-imidazo[4,5-b]pyridine ROR1 inhibitors include numbers 2, 3, 11, 15, 19, 27, 34, 43, 56, 64, 71, 75, 82, 96, 99, 117, 132, 147, 159, 168, 184, 232, 259, 265, 272, 288, 294, 302, supra.