HPV vaccine

Abstract

The invention relates to a nucleic acid encoding a polypeptide comprising a plurality of conserved peptide sequences, or variants thereof, wherein the conserved sequences are conserved across one or more HPV genotypes 16, 18, 31, 52, 53, and 58; and wherein the polypeptide comprises a conserved peptide sequence of each of the HPV proteins E1, E2, E4, E5, E6, and E7; and associated vaccines, viral vectors, treatment and prophylaxis.

Claims

1. A nucleic acid encoding a polypeptide comprising a plurality of conserved peptide sequences, wherein the conserved sequences are conserved across one or more HPV genotypes 16, 18, 31, 52, 53, and 58; and wherein the polypeptide comprises a conserved peptide sequence of each of the HPV proteins E1, E2, E4, E5, E6, and E7 wherein the polypeptide comprises: one or more conserved E1 sequence(s) selected from any one of SEQ ID NOs: 1-11, wherein each of the genotypes 16, 18, 31, 52, 53, and 58 are represented by at least one conserved E1 sequence; one or more conserved E2 sequence(s) selected from any one of SEQ ID NOs: 12-35, wherein each of the genotypes 16, 18, 31, 52, 53, and 58 are represented by at least one conserved E2 sequence; one or more conserved E4 sequence(s) selected from any one of SEQ ID NOs: 36-44, wherein each of the genotypes 16, 18, 31, 52, 53, and 58 are represented by at least one conserved E4 sequence; one or more conserved E5 sequence(s) selected from any one of SEQ ID NOs: 45-47, wherein each of the genotypes 16, 18, 31, 52, 53, and 58 are represented by at least one conserved E5 sequence; one or more conserved E6 sequence(s) selected from any one of SEQ ID NOs: 48-55, wherein each of the genotypes 16, 18, 31, 52, 53, and 58 are represented by at least one conserved E6 sequence; and one or more conserved E7 sequence(s) selected from any one of SEQ ID NOs: 56-59, wherein each of the genotypes 16, 18, 31, 52, 53, and 58 are represented by at least one conserved E7 sequence.

2. A nucleic acid encoding a polypeptide comprising a plurality of conserved peptide sequences, wherein the conserved sequences are conserved across one or more HPV genotypes 16, 18, 31, 52, 53, and 58; and wherein the polypeptide comprises a conserved peptide sequence of each of the HPV proteins E1, E2, E4, E5, E6, and E7, wherein the polypeptide comprises: one or more conserved E1 sequence(s) selected from any one of SEQ ID NOs: 1-11, wherein each of the genotypes 16, 18, 31, 52 and 58 are represented by at least one conserved E1 sequence; one or more conserved E2 sequence(s) selected from any one of SEQ ID NOs: 12-35, wherein each of the genotypes 16, 18, 31, 52 and 58 are represented by at least one conserved E2 sequence; one or more conserved E4 sequence(s) selected from any one of SEQ ID NOs: 36-44, wherein each of the genotypes 16, 18, 31, 52 and 58 are represented by at least one conserved E4 sequence; one or more conserved E5 sequence(s) selected from any one of SEQ ID NOs: 45-47, wherein each of the genotypes 16, 18, 31, 52 and 58 are represented by at least one conserved E5 sequence; one or more conserved E6 sequence(s) selected from any one of SEQ ID NOs: 48-55, wherein each of the genotypes 16, 18, 31, 52 and 58 are represented by at least one conserved E6 sequence; and one or more conserved E7 sequence(s) selected from any one of SEQ ID NOs: 56-59, wherein each of the genotypes 16, 18, 31, 52 and 58 are represented by at least one conserved E7 sequence.

3. A nucleic acid encoding a polypeptide comprising a plurality of conserved peptide sequences, wherein the conserved sequences are conserved across one or more HPV genotypes 16, 18, 31, 52, 53, and 58; and wherein the polypeptide comprises a conserved peptide sequence of each of the HPV proteins E1, E2, E4, E5, E6, and E7, wherein the nucleic acid comprises or consists of the sequence of SEQ ID NO: 60, comprises or consists of the sequence of SEQ ID NO: 65, or comprises or consists of the sequence of SEQ ID NO: 60, without encoding the TPA lead sequence.

4. A nucleic acid encoding a polypeptide comprising a plurality of conserved peptide sequences, wherein the conserved sequences are conserved across one or more HPV genotypes 16, 18, 31, 52, 53, and 58; and wherein the polypeptide comprises a conserved peptide sequence of each of the HPV proteins E1, E2, E4, E5, E6, and E7, wherein the nucleic acid comprises or consists of the sequence of SEQ ID NO: 62, or comprises or consists of the sequence of SEQ ID NO: 62, without encoding the TPA lead sequence.

5. A nucleic acid encoding a polypeptide comprising a plurality of conserved peptide sequences, wherein the conserved sequences are conserved across one or more HPV genotypes 16, 18, 31, 52, 53, and 58; and wherein the polypeptide comprises a conserved peptide sequence of each of the HPV proteins E1, E2, E4, E5, E6, and E7, wherein the nucleic acid comprises or consists of the sequence of SEQ ID NO: 71, 73 or 75; or the nucleic acid comprises or consists of the sequence of SEQ ID NO: 71, 73 or 75, and without encoding the TPA lead sequence.

6. A nucleic acid encoding a polypeptide comprising a plurality of conserved peptide sequences, wherein the conserved sequences are conserved across one or more HPV genotypes 16, 18, 31, 52, 53, and 58; and wherein the polypeptide comprises a conserved peptide sequence of each of the HPV proteins E1, E2, E4, E5, E6, and E7, wherein the polypeptide comprises or consists of the sequence of SEQ ID NO: 61, comprises or consists of the sequence of SEQ ID NO: 61 without the TPA lead sequence, or comprises or consists of the sequence of SEQ ID NO: 66.

7. A nucleic acid encoding a polypeptide comprising a plurality of conserved peptide sequences, wherein the conserved sequences are conserved across one or more HPV genotypes 16, 18, 31, 52, 53, and 58; and wherein the polypeptide comprises a conserved peptide sequence of each of the HPV proteins E1, E2, E4, E5, E6, and E7, wherein the polypeptide comprises or consists of the sequence of SEQ ID NO: 72, 74 or 76, or comprises or consists of the sequence of SEQ ID NO: 72, 74 or 76, without the TPA lead sequence.

Description

(1) Embodiments of the invention will now be described in more detail, by way of example only, with reference to the accompanying drawings.

(2) FIG. 1—Chimeric and Variant methods used to create HPV candidates.

(3) FIG. 2—Conserved regions with resultant variants below. See Table 9 for sequences and associated SEQ ID NO identifiers.

(4) FIG. 3—A) Regions identified as conserved in the two genotypes used to form chimerics. B) Conservation plot of Modified variant. See Table 9 for sequences and associated SEQ ID NO identifiers.

(5) FIG. 4—A) Regions identified as conserved in the two genotypes used to form chimerics. B) Conservation plot of variants, See Table 9 for sequences and associated SEQ ID NO identifiers.

(6) FIG. 5—Regions identified as conserved in the two genotypes used to form chimerics

(7) FIG. 6—Regions identified as conserved in the two genotypes used to form chimeric-variants

(8) FIG. 7—Regions identified as conserved in the two genotypes used to form chimeric

(9) FIG. 8—High frequencies of vaccine-specific T cells are induced following prime boost vaccination. IFNγ Elispot performed on PBMCs from C57BL/6 mice (six/group) primed intramuscularly with DNA-HPV, MVA-HPV or ChAdOx1-5GHPV3 and then boosted intramuscularly with a heterologous or homologous vaccine two weeks later. PBMCs were collected by tail vein bleed two weeks post prime and one and two weeks post boost.

(10) FIG. 9—Prime boost vaccination is capable of inducing responses to all antigens encoded in the immunogen. PBMCs were collected at two weeks boost and used in an IFNγ Elispot with peptides spanning the entire immunogen sequence, pooled according to protein source. Peptides spanning the E2 region of the immunogen were split into two pools because of the large number of peptides and peptides for regions spanning E4 and E5 were combined into one pool.

(11) FIG. 10—Vaccine-specific CD8+ T cells can be detected at high frequencies six weeks after ChAdOx1-5GHPV3 prime MVA-5GHPV3 boost. 10a IFNγ Elispot using PBMCs collected by tail vein bleed two, three, four and six weeks post boost (DM; DNA-5GHPV3 prime MVA-5GHPV3 boost, CM; ChAdOx1-5GHPV3 prime MVA-5GHPV3 boost). 10b ICS performed on PBMCs obtained one week and six weeks post ChAdOx1-5GHPV3 prime, MVA-5GHPV3 boost. PBMCs stimulated with E6 and E7 peptide pools. Measured IFN-γ, CD107, TNF-α and IL2.

(12) FIG. 11—HPV E6- and E7-specific CD8+ T cell responses are polyfunctional and have cytotoxic potential. PBMCs from a tail vein bleed collected one week post ChAdOx1-5GHPV3 prime MVA-5GHPV3 boost were stimulated with immunodominant peptide pools E6 and E7 and sub pool 22 which is the dominant sub pool within E6. Responding CD8+ T cells predominantly express three functions (CD107, IFNγ and TNFα).

(13) FIG. 12—ChAdOx1-5GHPV3 prime MVA-5GHPV3 boost also primes HPV E6- and E7-specific CD4+ T cell responses that are still detectable six weeks post boost. ICS performed on PBMCs obtained one week and six weeks post ChAdOx1-5GHPV3 prime, MVA-5GHPV3 boost. PBMCs stimulated with E6 and E7 peptide pools. Measured IFN-γ, CD107, TNF-α and IL2.

(14) FIG. 13—Most E6 and E7-specific CD4+ T cells express two functions. PBMCs from a tail vein bleed collected one week post ChAdOx1-5GHPV3 prime MVA-5GHPV3 boost were stimulated with immunodominant peptide pools E6 and E7 and sub pool 22 which is the dominant sub pool within E6. Responding CD4+ T cells predominantly express two functions (Discounting CD107+ monofunctional cells).

(15) FIG. 14—HPV E6- and E7-specific CD8+ T cells can be detected in the cervix. ICS was performed on cervicovaginal lymphocytes isolated from mice two weeks post ChAdOx1-5GHPV3 prime MVA-5GHPV3 boost and stimulated with immunodominant peptide pools E6 and E7 and sub pool 22. Measured IFN-γ, CD107, TNF-α and IL2.

(16) FIG. 15—Cervicovaginal HPV E6- and E7-specific CD8+ T cell responses are polyfunctional. Cervicovaginal lymphocytes collected one week post ChAdOx1-5GHPV3 prime MVA-5GHPV3 boost were stimulated with immunodominant peptide pools E6 and E7 and sub pool 22 which is the dominant sub pool within E6. Responding CD8+ T cells predominantly express three functions (CD107, IFNγ and TNFα).

(17) FIG. 16—Vaccine-induced E6 and E7-specific CD8+ and CD4+ T cells in the cervix are almost exclusively of effector phenotype. Naïve: CD44-CD62L+. Antigen-experienced: Central memory—CD62L+, CD127+; Effector memory—CD62L-, CD127+; Effector—CD62L-, CD127-. Cervical lymphocytes from six mice pooled into three pairs, due to low lymphocyte numbers

(18) FIG. 17—In contrast to cervix, vaccine-induced E6 and E7-specific CD8+ and CD4+ T cells in the spleen comprise effector and effector memory populations.

(19) FIG. 18—Mice vaccinated with ChAdOx1-5GHPV3 prime, MVA-5GHPV3 boost show increased survival over control mice. Mice were inoculated with 5×10.sup.4 TC-1 cells on day 0 and then primed on day 3 and boosted on day 17. Tumours were measured with digital callipers every two days and mice culled when tumours reached 10 mm in any one direction.

(20) FIG. 19—Vaccination of outbred CD1 mice induces high frequency T cell responses. IFNγ Elispot performed on PBMCs from CD1 mice (ten/group) primed intramuscularly with DNA-5GHPV3, MVA-5GHPV3 or ChAdOx1-5GHPV3 and then boosted intramuscularly with a heterologous or homologous vaccine two weeks later. PBMCs were collected by tail vein bleed two weeks post prime and two and three weeks post boost.

(21) FIG. 20—T cell responses in vaccinated CD1 mice are directed across the entire immunogen. PBMCs were collected at two weeks boost and used in an IFNγ Elispot with peptides spanning the entire immunogen sequence, pooled according to protein source. Peptides spanning the E2 region of the immunogen were split into two pools because of the large number of peptides and peptides for regions spanning E4 and E5 were combined into one pool.

(22) FIG. 21—Top panel: Peripheral blood mononuclear cells (PBMC) from 76 women aged 16-24 years were tested for recognition of peptides based on early proteins from high risk HPV (hrHPV) in ex vivo IFN-γ Elispot assays. ‘Insert’ is a pool of 15-mer peptides overlapping by 11 amino acid spanning the hrHPV transgene. ‘Reference’ peptides were pools of peptides based on early proteins from HPV16 and HPV52, which were combined as follows: E1/E2, E4/E5 and E6/E7. TEC′ (flu, EBV and CMV) peptides and PHA (phytohaemaglutinnin) were used as positive controls. The data shown are the spot-forming units (SFU) obtained from peptide-stimulated wells after subtraction of negative control values (mock-stimulated cells). The cut-off for a positive response was set at 25 SFU/million PBMC (derived from the mean of mock-stimulated values from all donors+2 standard deviations). Women were tested concurrently for hrHPV DNA on vaginal sampling: 26% tested positive. The data show that 9/76 women with current hrHPV infection or prior exposure recognised HPV sequences encoded in the transgene. Bottom panel: Responses to the insert pool were interrogated further in one responding donor by testing PBMC with subpools of the insert pool (left, SFU per million PBMC), followed by individual peptides within the pools (right, SFU per well), thus confirming the presence of a true HPV-specific response. SFU—spot-forming units reported as either per well, which contains 200,000 PBMC or per million PBMC).

(23) FIG. 22—Subpool mapping in C57BL/6 mice (top panel) and CD1 mice (bottom panel) following ChAdOX1-5G-HPV3 prime MVA-5GHPV3 boost. Mice were culled two weeks post boost and splenocytes isolated. Splenocytes used in an IFNγ Elispot assay using subpools that cover the immunogen sequence. Subpools 21, 25 and 26 (for example) contain no HPV53 sequences and still get high magnitude responses, thus providing evidence that a sequence without the HPV53 segments would still be immunogenic.

(24) HPV Immunogen Design

(25) The HPV immunogen is composed of amino acid fragments conserved and geographically representative of the global HPV population at a protein level. Each fragment is created using a conservation algorithm which has been utilised to create either Chimeric or Variant based fragments. The choice being dependent on characteristics of each HPV protein used.

(26) The core conservation algorithm uses a sliding window approach in combination with a normalisation method that accounts for collection bias to identify windows which are conserved both within (intra-genotype) and between (inter-genotype) genotypes. Intra-genotype conserved windows are classed as windows with a conservation value less than one quartile of the sum of all window conservation values for the whole sequence. A normalised representative consensus sequence is created for each genotype during this process. Subsequently inter-genotype windows are identified as windows at the same position in each genotype which are conserved and have a shared consensus identity of >60%.

(27) A key challenge in creating sequences which represent all the selected genotypes for a region of each protein was that many genotypes showed unique phylogenetic clustering. There is a critical balance between the identification of regions conserved across genotypes and the level of shared % consensus identity between these regions. In many cases the inter-genotype diversity was so extreme that you sacrifice shared % consensus identity. Meaning some genotypes were so distinct from one another it was impossible to create a representative sequence. To solve this, raw sequences were inputted into the core algorithm in one of two ways (FIG. 1). (i) Variants; Sequences for all genotypes are input into the algorithm and regions of inter-genotype conservation are identified independent of shared % consensus identity. A phylogeny was created from the resultant regions and ingroup sequences combined to create a consensus with a high level of shared consensus identity (FIG. 1b). (ii) Chimerics; in some instances the distance between genotypes is so significant that genotypes do not align suitably. Therefore, only genotype ingroups are inputted together into the algorithm, and regions conserved between ingroups with >60% shared consensus identity are identified (FIG. 1a).

(28) HPV Candidates

(29) Candidate sequences were created for six HPV proteins (E1-2, E4-7) using input sequences collected from the NCBI protein database, aligned and manually audited to remove incomplete and poor quality sequences (Table 1).

(30) TABLE-US-00001 TABLE 1 Number of sequences used as input post audit. Genotype Protein 16 18 31 52 53 58 E1 126 49 24 27 15 53 E2 195 56 26 32 18 54 E4 161 48 24 24 14 52 E5 197 48 24 24 — 60 E6 1205 78 90 218 131 185 E7 566 70 85 193 114 199

(31) TABLE-US-00002 Approach: Variants Fragments: 1 E1_V1_52 + 58: DEDETAYDSGTDLIDFIDDS (SEQ ID NO: 1) E1_V1_31 + 16 + 18: DENENDSDTGEDMVDFIDN (SEQ ID NO: 2) E1_V1_53: DETDEESTESDLDGFIDNS (SEQ ID NO: 3) 2 Excluded 3 E1_V3_31 + 53: AQLADSDSNACAFLK (SEQ ID NO: 4) E1_V3_52 + 58 + 18 + 3016: AQLADVNSNAAAFLK (SEQ ID NO: 5) 4 E1_V4_16 + 31: NCILLYGAANTGKSLFGMSL (SEQ ID NO: 6) E1_V4_18 + 52 + 58: NCLVLCGPANTGKSYFGMSL (SEQ ID NO: 7) E1_V4_53: NCLVIYGPPNTGKSCFAMSL (SEQ ID NO: 8) 5 E1_V5_16 + 31 + 52: WPYLHSRLVVFTFPNPF (SEQ ID NO: 9) E1_V5_18 + 58: WPYLESRITVFEFPNAF (SEQ ID NO: 10) E1_V5_53: LRYLHSRIHVLQFLNPF (SEQ ID NO: 11)

(32) Identified 5 fragments within the E1 protein with windows conserved at the same position within their respective genotypes. Cladistics identified the most suitable genotype combinations providing high level shared consensus identity (FIG. 2).

(33) TABLE-US-00003 Approach: Chimerics Fragments: 1 E2_C1-1_16 + 31 NVCQDKILEHYENDSKD (SEQ ID (16 + 31) NO: 12) E2_C1-2_16 + 31 ILEHYENDSKDLCDHI (SEQ ID NO: 13) E2_C1-3_16 + 31 CDHIDYWKHIRLECAIMYKAR (SEQ ID NO: 14) E2_C1-4_16 + 31 IRLECAIMYKAREMGFH (SEQ ID NO: 15) E2_C1-5_16 + 31 QFDGDICNTMHYTNW (SEQ ID NO: 16) E2_C1-6_16 + 31 IYICEDAQCTVVEGQVD (SEQ ID NO: 17) E2_C1-7_16 + 31 KKWEVHAGGQVILCPES (SEQ ID NO: 18) E2_C1-8_16 + 31 GQRRIKRPRSE (SEQ ID NO: 19) E2_C1-9_16 + 31 NCHPNKLL (SEQ ID NO: 20) E2_C1-10_16 + 31 ILKCLRYRFKKHCKL (SEQ ID NO: 21) E2_C1-11_16 + 31 SSTWHWTCHDGKHK (SEQ ID NO: 22) E2_C1-12_16 + 31 WHWTCHDGKHKNAIVTLTY (SEQ ID NO: 23) 2 E2_C1-1_52 + 58 (52 + 58) YEADKNDLNAQIEHWKLIRMECAIFYKAKELGIS (SEQ ID NO: 24) E2_C1-2_52 + 58 ICHQVVPPLAASKAKACQAIELQLALEALNASPY (SEQ ID NO: 25) E2_C1-3_52 + 58 DEWTLQQTSLEMWLAEPQ (SEQ ID NO: 26) E2_C1-4_52 + 58 FKKHGITITVQYDNDKANTMDYTNWKEIY (SEQ ID NO: 27) E2_C1-5_52 + 58 VIVCPASIPSDEISTEEA (SEQ ID NO: 28) 3 E2_C1-1_53 + 18 DHIDYWKAIRQENAIFFAAR (SEQ (53 + 18) ID NO: 29) E2_C1-2_53 + 18 HQVVPALNICKAKACKAIE (SEQ ID NO: 30) E2_C1-3_53 + 18 WNTEPKHCFKKGGQHIEVWFD (SEQ ID NO: 31) E2_C1-4_53 + 18 YVAWDSVYYCGDDGWCKT (SEQ ID NO: 32) E2_C1-5_53 + 18 EAEKYGCKGTWEVHFG (SEQ ID NO: 33) E2_C1-6_53 + 18 NSIDCNDSMCSTFDDNVSATELVK (SEQ ID NO: 34) Approach: Modified Variant Fragments: 1 E2_FC1_All DHIDYWKLIRLECAIFYKAR (SEQ ID NO: 35)

(34) Due to alignment inconsistencies three chimerics were created based on phylogeny (16 & 31, 52 & 58, 53 & 18) (FIG. 3a). Additionally all genotypes were inputted into the algorithm in a similar fashion to creation of variants but the programs filter for only selecting conserved windows from each genotype with a shared % consensus identity of greater than 60% was not disabled. This identified one fragment, referred to as ‘modified variant’ (FIG. 3b).

(35) TABLE-US-00004 Approach: Chimerics Fragments: 1 E4_C1-1_16 + 31 RRLSSDQDQSQ (SEQ ID NO: 36) (16 + 31) 2 E4_C1-1_52 + 58 LVTKYPLLKLLS (SEQ ID NO: 37) (52 + 58) 3 E4_C1-1_53 (53) RPPNMGVKAHGKCIWENKVFIVPTLCPVPLDPTYP LLKLLT (SEQ ID NO: 38) E4_C1-2_53 TQTTTPENTSLVELRVTTPKSTVVIRLHL (SEQ ID NO: 39) 4 E4_C1-1_18 TTRYPLLSLLNSYSTPPHRIPAPCPWAPQRP (18) (SEQ ID NO: 40) Approach: Variants Fragments: 1 E4_V1_16 + 31 PIPKPSPWAP (SEQ ID NO: 41) E4_V1_18 RIPAPCPWAP (SEQ ID NO: 42) E4_V1_52 PRPPHCPWVP (SEQ ID NO: 43) E4_V1_53 PPPPPRPWAP (SEQ ID NO: 44) E4_V1_58 Excluded

(36) Four chimerics were created, two of the fragments are genotype specific (FIG. 4a). Additionally, variant analysis identified one region (FIG. 4b).

(37) TABLE-US-00005 Approach: Chimerics Fragments: 1 E5_C1_16_31 CFLLCFCVLLCVCLLIRPLLLSVSTY (SEQ (16 + 31) ID NO: 45) 2 E5_C1_52 + 58 LRPLLLSISVYAQVLVLVLLLWVSIGS (52 + 58) (SEQ ID NO: 46) 3 E5_C1_18 (18) LLPSVCMCAYAWVLVFVYIVVITSPATA (SEQ ID NO: 47)

(38) Three chimerics were created (FIG. 5).

(39) TABLE-US-00006 Approach: Chimeric-Variants Fragments: 1 E6_CV1_16 (16 + 18) IVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQY NKPLCDLLIRCIN (SEQ ID NO: 48) E6_CV1_18 VVYRDSIPHAACHKCIDFYSRIRELRHYSDSVYGDTLEKLTN TGLYNLLIRCLR (SEQ ID NO: 49) 2 E6_CV2-1_53 VFCKKALTASEVYNFAYTDLRVVYRD (SEQ (53 + 31) ID NO: 50) E6_CV2-2_53 SKVRKLRYYNCSVYGASL (SEQ ID NO: 51) E6_CV2-1_31 VYCKGQLTETEVLDFAFTDLTIVYRD (SEQ ID NO: 52) E6_CV2-2_31 SKVSEFRWYRYSVYGTTL (SEQ ID NO: 53) 3 E6_CV3-1_52 + 58 CVECKKTLQRSEVYD (SEQ ID NO: 54) (5258) E6_CV3-2_52 + 58 CQRPLCPQEKKRHVDLNKRFH (SEQ ID NO: 55)

(40) The E6 protein showed very limited conservation across genotypes. Instead ingroups were processed to produce chimerics without the shared % consensus identity filter, but the conserved windows were not combined to produce a consensus, except for genotypes 52 and 58. (FIG. 6)

(41) TABLE-US-00007 Approach: Chimerics Fragments: 1 E7_C1_16 + 31 TLHEYMLDLQPETTDLYCYEQ (SEQ ID (16 + 31) NO: 56) 2 E7_58_52 (52 + 58) PETTDLHCYEQLGDSSDEEDTGGLDG (SEQ ID NO: 57) 3 Excluded (53 + 18) Approach: Chimeric-Variants Fragments: 1 E7_V1_53 DEDEDEVDHLQEQPQQARRDEQHPCYLIETQCCR CESLV (SEQ ID NO: 58) E7_V1_18 EENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCE ARI (SEQ ID NO: 59)

(42) Chimerics were created for Genotypes 16 & 31 and 52 & 58 (FIG. 7). Genotypes 53 and 18 are chimeric variants.

(43) TABLE-US-00008 SEQ ID NO: Protein Fragment  1 E1_V1_52 + 58 DEDETAYDSGTDLIDFIDDS  2 E1_V1_31 + 16 + 18 DENENDSDTGEDMVDFIDN  3 E1_V1_53 DETDEESTESDLDGFIDNS  4 E1_V3_31 + 53 AQLADSDSNACAFLK  5 E1_V3_52 + 58 + AQLADVNSNAAAFLK 18 + 16  6 E1_V4_16 + 31 NCILLYGAANTGKSLFGMSL  7 E1_V4_18 + 52 + 58 NCLVLCGPANTGKSYFGMSL  8 E1_V4_53 NCLVIYGPPNTGKSCFAMSL  9 E1_V5_16 + 31 + 52 WPYLHSRLVVFTFPNPF 10 E1_V5_18 + 58 WPYLESRITVFEFPNAF 11 E1_V5_53 LRYLHSRIHVLQFLNPF 12 E2_C1-1_16 + 31 NVCQDKILEHYENDSKD 13 E2_C1-2_16 + 31 ILEHYENDSKDLCDHI 14 E2_C1-3_16 + 31 CDHIDYWKHIRLECAIMYKAR 15 E2_C1-4_16 + 31 IRLECAIMYKAREMGFH 16 E2_C1-5_16 + 31 QFDGDICNTMHYTNW 17 E2_C1-6_16 + 31 IYICEDAQCTVVEGQVD 18 E2_C1-7_16 + 31 KKWEVHAGGQVILCPES 19 E2_C1-8_16 + 31 GQRRIKRPRSE 20 E2_C1-9_16 + 31 NCHPNKLL 21 E2_C1-10_16 + 31 ILKCLRYRFKKHCKL 22 E2_C1-11_16 + 31 SSTWHWTCHDGKHK 23 E2_C1-12_16 + 31 WHWTCHDGKHKNAIVTLTY 24 E2_C1-1_52 + 58 YEADKNDLNAQIEHWKLIRMECAIFYKAKELGIS 25 E2_C1-2_52 + 58 ICHQVVPPLAASKAKACQAIELQLALEALNASPY 26 E2_C1-3_52 + 58 DEWTLQQTSLEMWLAEPQ 27 E2_C1-4_52 + 58 FKKHGITITVQYDNDKANTMDYTNWKEIY 28 E2_C1-5_52 + 58 VIVCPASIPSDEISTEEA 29 E2_C1-1_53 + 18 DHIDYWKAIRQENAIFFAAR 30 E2_C1-2_53 + 18 HQVVPALNICKAKACKAIE 31 E2_C1-3_53 + 18 WNTEPKHCFKKGGQHIEVWFD 32 E2_C1-4_53 + 18 YVAWDSVYYCGDDGWCKT 33 E2_C1-5_53 + 18 EAEKYGCKGTWEVHFG 34 E2_C1-6_53 + 18 NSIDCNDSMCSTFDDNVSATELVK 35 E2_FC1_All DHIDYWKLIRLECAIFYKAR 36 E4_C1-1_16 + 31 RRLSSDQDQSQ 37 E4_C1-1_52 + 58 LVTKYPLLKLLS 38 E4_C1-1_53 RPPNMGVKAHGKCIWENKVFIVPTLCPVPLDPTYPLLKLLT 39 E4_C1-2_53 TQTTTPENTSLVELRVTTPKSTVVIRLHL 40 E4_C1-1_18 TTRYPLLSLLNSYSTPPHRIPAPCPWAPQRP 41 E4_V1_16 + 31 PIPKPSPWAP 42 E4_V1_18 RIPAPCPWAP 43 E4_V1_52 PRPPHCPWVP 44 E4_V1_53 PPPPPRPWAP 45 E5_C1_16_31 CFLLCFCVLLCVCLLIRPLLLSVSTY 46 E5_C1_52 + 58 LRPLLLSISVYAQVLVLVLLLWVSIGS 47 E5_C1_18 LLPSVCMCAYAWVLVFVYIVVITSPATA 48 E6_CV1_16 IVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIR CIN 49 E6_CV1_18 VVYRDSIPHAACHKCIDFYSRIRELRHYSDSVYGDTLEKLTNTGLYNLLIR CLR 50 E6_CV2-1_53 VFCKKALTASEVYNFAYTDLRVVYRD 51 E6_CV2-2_53 SKVRKLRYYNCSVYGASL 52 E6_CV2-1_31 VYCKGQLTETEVLDFAFTDLTIVYRD 53 E6_CV2-2_31 SKVSEFRWYRYSVYGTTL 54 E6_CV3-1_52 + 58 CVECKKTLQRSEVYD 55 E6_CV3-2_52 + 58 CQRPLCPQEKKRHVDLNKRFH 56 E7_C1_16 + 31 TLHEYMLDLQPETTDLYCYEQ 57 E7_C1_58_52 PETTDLHCYEQLGDSSDEEDTGGLDG 58 E7_V1_53 DEDEDEVDHLQEQPQQARRDEQHPCYLIETQCCRCESLV 59 E7_V1_18 EENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCEARI
HPV3 Nucleotide Sequence (SEQ ID NO: 60)

(44) From Start codon, starting with the TPA leading sequence encoded with an additional linker (TPA and linker are bold and underlined).

(45) TABLE-US-00009 ATGGATGCTATGAAGAGGGGCCTGTGCTGCGTGCTGCTGCTGTGTGGCGC CGTGTTTGTGTCCCCCAGCCAGGAAATCCACGCCCGGTTCAGAAGAGGCA GCAAGCTGGCCGACGAGGACGAGACAGCCTACGACAGCGGCACCGACCTG ATCGACTTCATCGACGACAGCGACGAGAATGAGAACGACTCCGACACCGG CGAGGACATGGTGGATTTCATCGACAACGACGAAACCGACGAAGAGAGCA CCGAGAGCGACCTGGACGGCTTTATCGACAACTCCGCCCAGCTGGCTGAC AGCGACAGCAATGCCTGCGCCTTCCTGAAGGCTCAGCTGGCAGACGTGAA CAGCAACGCCGCTGCTTTTCTGAAGAACTGCATCCTGCTGTACGGCGCTG CCAACACCGGCAAGAGCCTGTTCGGCATGAGCCTGAACTGCCTGGTGCTG TGCGGCCCAGCCAATACCGGAAAGTCCTACTTCGGCATGTCCCTGAATTG TCTCGTGATCTACGGCCCACCTAACACAGGCAAGTCCTGCTTTGCCATGT CTCTGTGGCCCTACCTGCACAGCAGACTGGTGGTGTTTACCTTCCCCAAC CCCTTCTGGCCTTACCTGGAAAGCCGGATCACCGTGTTCGAGTTCCCCAA TGCCTTTCTGAGATACCTGCACTCCCGGATCCACGTGCTGCAGTTTCTGA ACCCCTTCAACGTGTGCCAGGACAAGATCCTGGAACACTACGAGAACGAC AGCAAGGACATTCTGGAACATTATGAGAATGATTCCAAGGACCTGTGCGA CCACATCTGCGATCACATCGACTACTGGAAGCACATCCGGCTGGAATGCG CCATCATGTACAAGGCCCGGATCAGACTGGAATGTGCTATTATGTATAAG GCTCGCGAGATGGGCTTCCACCAGTTCGACGGCGACATCTGCAACACCAT GCACTACACCAACTGGATCTATATCTGCGAGGACGCCCAGTGCACCGTGG TGGAAGGCCAGGTGGACAAGAAATGGGAGGTGCACGCTGGCGGCCAAGTG ATCCTGTGTCCTGAGAGCGGCCAGCGGCGGATCAAGAGGCCCAGAAGCGA GAACTGCCACCCCAACAAGCTGCTGATCCTGAAGTGCCTGCGGTACAGAT TCAAGAAGCACTGCAAGCTGAGCAGCACCTGGCACTGGACCTGCCACGAC GGCAAGCACAAGTGGCATTGGACATGTCACGATGGGAAACACAAGAACGC CATTGTGACCCTGACCTACTACGAGGCCGACAAGAACGACCTGAACGCCC AGATCGAGCACTGGAAACTGATCCGGATGGAATGTGCAATCTTCTATAAG GCCAAAGAGCTGGGCATCAGCATCTGCCACCAGGTGGTGCCTCCACTGGC CGCCTCTAAAGCCAAAGCCTGCCAGGCCATCGAACTGCAGCTGGCCCTGG AAGCCCTGAATGCCAGCCCCTACGATGAGTGGACCCTGCAGCAGACCAGC CTGGAAATGTGGCTGGCCGAGCCCCAGTTTAAGAAGCACGGCATCACCAT CACCGTGCAGTACGACAATGACAAGGCCAATACCATGGATTACACAAATT GGAAAGAAATCTACGTGATCGTGTGCCCCGCCAGCATCCCCTCCGATGAG ATCAGCACCGAGGAAGCCGACCACATTGATTATTGGAAAGCCATCAGGCA GGAAAACGCCATCTTCTTCGCCGCCAGACACCAGGTGGTGCCCGCCCTGA ATATCTGCAAGGCCAAGGCCTGTAAAGCCATCGAGTGGAACACCGAGCCC AAGCACTGCTTCAAGAAGGGCGGCCAGCACATCGAAGTGTGGTTCGACTA CGTGGCCTGGGACAGCGTGTACTACTGCGGCGACGATGGCTGGTGCAAGA CCGAGGCCGAGAAGTACGGCTGCAAGGGCACCTGGGAAGTGCATTTCGGC AACAGCATCGACTGCAACGACTCCATGTGCAGCACCTTCGACGACAACGT GTCCGCCACCGAGCTCGTGAAGGACCATATCGACTATTGGAAGCTGATTC GCCTGGAATGTGCCATTTTTTACAAGGCCAGACGGCGGCTGTCCAGCGAC CAGGATCAGTCTCAGCTCGTGACCAAGTACCCCCTGCTGAAGCTGCTGTC CAGACCCCCCAACATGGGCGTGAAGGCCCACGGCAAGTGCATCTGGGAGA ACAAGGTGTTCATCGTGCCCACCCTGTGCCCCGTGCCTCTGGATCCAACA TATCCTCTGCTGAAACTGCTGACCACCCAGACCACCACCCCCGAGAATAC CTCCCTGGTGGAACTGAGAGTGACCACCCCCAAGAGCACAGTCGTGATCA GGCTGCACCTGACCACCAGATACCCACTGCTGTCACTGCTGAACAGCTAC AGCACCCCCCCTCACCGGATCCCTGCTCCATGTCCTTGGGCTCCTCAGAG GCCCCCCATCCCTAAGCCTTCTCCATGGGCCCCTAGAATCCCTGCCCCTT GCCCCTGGGCACCTCCTAGACCTCCACACTGTCCATGGGTGCCCCCTCCA CCTCCTCCAAGACCTTGGGCCCCTTGCTTCCTGCTGTGCTTTTGTGTGCT GCTGTGCGTGTGCCTGCTGATCAGACCCCTGCTGCTGAGTGTGTCCACCT ACCTGAGGCCTCTGCTGCTGTCTATCAGCGTGTACGCTCAGGTGCTGGTG CTGGTGCTGCTGCTGTGGGTGTCCATCGGAAGCCTGCTGCCCAGCGTGTG CATGTGTGCCTATGCCTGGGTGCTGGTGTTCGTGTACATCGTCGTGATTA CCAGCCCCGCCACCGCCATCGTGTACCGGGATGGCAATCCTTACGCCGTG TGCGACAAGTGCCTGAAGTTCTACAGCAAGATCAGCGAGTACCGGCACTA CTGCTACAGCCTGTACGGCACCACCCTGGAACAGCAGTACAACAAGCCCC TGTGCGATCTGCTGATTCGGTGCATCAACGTGGTGTACAGAGACTCCATC CCCCACGCCGCCTGCCACAAGTGTATCGACTTCTACTCCAGAATCAGAGA GCTGCGGCACTACAGCGACTCCGTGTACGGCGATACCCTGGAAAAGCTGA CCAACACTGGCCTGTACAACCTGCTGATTAGATGCCTGCGGGTGTTCTGC AAGAAGGCCCTGACAGCCAGCGAGGTGTACAACTTCGCCTACACCGATCT GCGGGTGGTGTATCGGGACAGCAAAGTGCGGAAGCTGAGGTACTACAACT GCTCTGTGTATGGCGCCAGCCTGGTGTATTGCAAGGGACAGCTGACCGAG ACAGAGGTGCTGGATTTCGCCTTCACAGACCTGACAATCGTGTATCGCGA CTCCAAGGTGTCCGAGTTCCGGTGGTACAGATATTCCGTGTATGGCACCA CACTGTGCGTGGAATGCAAGAAAACCCTGCAGAGATCTGAGGTGTACGAC TGCCAGCGGCCACTGTGTCCGCAGGAAAAGAAAAGACACGTGGACCTGAA CAAGCGGTTCCACACCCTGCACGAGTACATGCTGGATCTGCAGCCCGAGA CAACCGACCTGTACTGCTACGAGCAGCCTGAAACCACTGATCTGCACTGT TATGAGCAGCTGGGAGACAGCTCCGATGAAGAGGACACTGGCGGCCTGGA TGGGGACGAGGATGAGGACGAAGTGGACCATCTGCAGGAACAGCCCCAGC AGGCTAGACGGGACGAACAGCACCCTTGCTATCTGATCGAGACACAGTGC TGCAGATGCGAATCTCTGGTGGAAGAGAACGACGAGATCGACGGCGTGAA CCACCAGCATCTGCCCGCTAGAAGGGCCGAGCCTCAGAGACACACCATGC TGTGTATGTGCTGCAAGTGCGAGGCCAGAATCGCCGGCTCTGGACCTGGC GCCTCTGGCAAGCCTATCCCCAATCCACTGCTGGGCCTGGACTCCACCCG GACCTGATAA
HPV3 Nucleotide Sequence without Encoding a Peptide Adjuvant/TPA (SEQ ID NO: 65)

(46) TABLE-US-00010 GACGAGGACGAGACAGCCTACGACAGCGGCACCGACCTG ATCGACTTCATCGACGACAGCGACGAGAATGAGAACGACTCCGACACCGG CGAGGACATGGTGGATTTCATCGACAACGACGAAACCGACGAAGAGAGCA CCGAGAGCGACCTGGACGGCTTTATCGACAACTCCGCCCAGCTGGCTGAC AGCGACAGCAATGCCTGCGCCTTCCTGAAGGCTCAGCTGGCAGACGTGAA CAGCAACGCCGCTGCTTTTCTGAAGAACTGCATCCTGCTGTACGGCGCTG CCAACACCGGCAAGAGCCTGTTCGGCATGAGCCTGAACTGCCTGGTGCTG TGCGGCCCAGCCAATACCGGAAAGTCCTACTTCGGCATGTCCCTGAATTG TCTCGTGATCTACGGCCCACCTAACACAGGCAAGTCCTGCTTTGCCATGT CTCTGTGGCCCTACCTGCACAGCAGACTGGTGGTGTTTACCTTCCCCAAC CCCTTCTGGCCTTACCTGGAAAGCCGGATCACCGTGTTCGAGTTCCCCAA TGCCTTTCTGAGATACCTGCACTCCCGGATCCACGTGCTGCAGTTTCTGA ACCCCTTCAACGTGTGCCAGGACAAGATCCTGGAACACTACGAGAACGAC AGCAAGGACATTCTGGAACATTATGAGAATGATTCCAAGGACCTGTGCGA CCACATCTGCGATCACATCGACTACTGGAAGCACATCCGGCTGGAATGCG CCATCATGTACAAGGCCCGGATCAGACTGGAATGTGCTATTATGTATAAG GCTCGCGAGATGGGCTTCCACCAGTTCGACGGCGACATCTGCAACACCAT GCACTACACCAACTGGATCTATATCTGCGAGGACGCCCAGTGCACCGTGG TGGAAGGCCAGGTGGACAAGAAATGGGAGGTGCACGCTGGCGGCCAAGTG ATCCTGTGTCCTGAGAGCGGCCAGCGGCGGATCAAGAGGCCCAGAAGCGA GAACTGCCACCCCAACAAGCTGCTGATCCTGAAGTGCCTGCGGTACAGAT TCAAGAAGCACTGCAAGCTGAGCAGCACCTGGCACTGGACCTGCCACGAC GGCAAGCACAAGTGGCATTGGACATGTCACGATGGGAAACACAAGAACGC CATTGTGACCCTGACCTACTACGAGGCCGACAAGAACGACCTGAACGCCC AGATCGAGCACTGGAAACTGATCCGGATGGAATGTGCAATCTTCTATAAG GCCAAAGAGCTGGGCATCAGCATCTGCCACCAGGTGGTGCCTCCACTGGC CGCCTCTAAAGCCAAAGCCTGCCAGGCCATCGAACTGCAGCTGGCCCTGG AAGCCCTGAATGCCAGCCCCTACGATGAGTGGACCCTGCAGCAGACCAGC CTGGAAATGTGGCTGGCCGAGCCCCAGTTTAAGAAGCACGGCATCACCAT CACCGTGCAGTACGACAATGACAAGGCCAATACCATGGATTACACAAATT GGAAAGAAATCTACGTGATCGTGTGCCCCGCCAGCATCCCCTCCGATGAG ATCAGCACCGAGGAAGCCGACCACATTGATTATTGGAAAGCCATCAGGCA GGAAAACGCCATCTTCTTCGCCGCCAGACACCAGGTGGTGCCCGCCCTGA ATATCTGCAAGGCCAAGGCCTGTAAAGCCATCGAGTGGAACACCGAGCCC AAGCACTGCTTCAAGAAGGGCGGCCAGCACATCGAAGTGTGGTTCGACTA CGTGGCCTGGGACAGCGTGTACTACTGCGGCGACGATGGCTGGTGCAAGA CCGAGGCCGAGAAGTACGGCTGCAAGGGCACCTGGGAAGTGCATTTCGGC AACAGCATCGACTGCAACGACTCCATGTGCAGCACCTTCGACGACAACGT GTCCGCCACCGAGCTCGTGAAGGACCATATCGACTATTGGAAGCTGATTC GCCTGGAATGTGCCATTTTTTACAAGGCCAGACGGCGGCTGTCCAGCGAC CAGGATCAGTCTCAGCTCGTGACCAAGTACCCCCTGCTGAAGCTGCTGTC CAGACCCCCCAACATGGGCGTGAAGGCCCACGGCAAGTGCATCTGGGAGA ACAAGGTGTTCATCGTGCCCACCCTGTGCCCCGTGCCTCTGGATCCAACA TATCCTCTGCTGAAACTGCTGACCACCCAGACCACCACCCCCGAGAATAC CTCCCTGGTGGAACTGAGAGTGACCACCCCCAAGAGCACAGTCGTGATCA GGCTGCACCTGACCACCAGATACCCACTGCTGTCACTGCTGAACAGCTAC AGCACCCCCCCTCACCGGATCCCTGCTCCATGTCCTTGGGCTCCTCAGAG GCCCCCCATCCCTAAGCCTTCTCCATGGGCCCCTAGAATCCCTGCCCCTT GCCCCTGGGCACCTCCTAGACCTCCACACTGTCCATGGGTGCCCCCTCCA CCTCCTCCAAGACCTTGGGCCCCTTGCTTCCTGCTGTGCTTTTGTGTGCT GCTGTGCGTGTGCCTGCTGATCAGACCCCTGCTGCTGAGTGTGTCCACCT ACCTGAGGCCTCTGCTGCTGTCTATCAGCGTGTACGCTCAGGTGCTGGTG CTGGTGCTGCTGCTGTGGGTGTCCATCGGAAGCCTGCTGCCCAGCGTGTG CATGTGTGCCTATGCCTGGGTGCTGGTGTTCGTGTACATCGTCGTGATTA CCAGCCCCGCCACCGCCATCGTGTACCGGGATGGCAATCCTTACGCCGTG TGCGACAAGTGCCTGAAGTTCTACAGCAAGATCAGCGAGTACCGGCACTA CTGCTACAGCCTGTACGGCACCACCCTGGAACAGCAGTACAACAAGCCCC TGTGCGATCTGCTGATTCGGTGCATCAACGTGGTGTACAGAGACTCCATC CCCCACGCCGCCTGCCACAAGTGTATCGACTTCTACTCCAGAATCAGAGA GCTGCGGCACTACAGCGACTCCGTGTACGGCGATACCCTGGAAAAGCTGA CCAACACTGGCCTGTACAACCTGCTGATTAGATGCCTGCGGGTGTTCTGC AAGAAGGCCCTGACAGCCAGCGAGGTGTACAACTTCGCCTACACCGATCT GCGGGTGGTGTATCGGGACAGCAAAGTGCGGAAGCTGAGGTACTACAACT GCTCTGTGTATGGCGCCAGCCTGGTGTATTGCAAGGGACAGCTGACCGAG ACAGAGGTGCTGGATTTCGCCTTCACAGACCTGACAATCGTGTATCGCGA CTCCAAGGTGTCCGAGTTCCGGTGGTACAGATATTCCGTGTATGGCACCA CACTGTGCGTGGAATGCAAGAAAACCCTGCAGAGATCTGAGGTGTACGAC TGCCAGCGGCCACTGTGTCCGCAGGAAAAGAAAAGACACGTGGACCTGAA CAAGCGGTTCCACACCCTGCACGAGTACATGCTGGATCTGCAGCCCGAGA CAACCGACCTGTACTGCTACGAGCAGCCTGAAACCACTGATCTGCACTGT TATGAGCAGCTGGGAGACAGCTCCGATGAAGAGGACACTGGCGGCCTGGA TGGGGACGAGGATGAGGACGAAGTGGACCATCTGCAGGAACAGCCCCAGC AGGCTAGACGGGACGAACAGCACCCTTGCTATCTGATCGAGACACAGTGC TGCAGATGCGAATCTCTGGTGGAAGAGAACGACGAGATCGACGGCGTGAA CCACCAGCATCTGCCCGCTAGAAGGGCCGAGCCTCAGAGACACACCATGC TGTGTATGTGCTGCAAGTGCGAGGCCAGAATCGCCGGCTCTGGACCTGGC GCCTCTGGCAAGCCTATCCCCAATCCACTGCTGGGCCTGGACTCCACCCG GACCTGATAA
HPV3 Polypeptide Sequence (SEQ ID NO: 61)

(47) From Start codon, starting with the TPA leading sequence.

(48) TABLE-US-00011 MDAMKRGLCCVLLLCGAVEVSPSQEIHARFRRGSKLADEDETAYDSGTDL IDFIDDSDENENDSDTGEDMVDFIDNDETDEESTESDLDGFIDNSAQLAD SDSNACAFLKAQLADVNSNAAAFLKNCILLYGAANTGKSLFGMSLNCLVL CGPANTGKSYEGMSLNCLVIYGPPNTGKSCFAMSLWPYLHSRLVVETFPN PFWPYLESRITVFEFPNAFLRYLHSRIHVLQFLNPFNVCQDKILEHYEND SKDILEHYENDSKDLCDHICDHIDYWKHIRLECAIMYKARIRLECAIMYK AREMGFHQFDGDICNTMHYTNWIYICEDAQCTVVEGQVDKKWEVHAGGQV ILCPESGQRRIKRPRSENCHPNKLLILKCLRYRFKKHCKLSSTWHWTCHD GKHKWHWTCHDGKHKNAIVTLTYYEADKNDLNAQIEHWKLIRMECAIFYK AKELGISICHQVVPPLAASKAKACQAIELQLALEALNASPYDEWTLQQTS LEMWLAEPQFKKHGITITVQYDNDKANTMDYTNWKEIYVIVCPASIPSDE ISTEEADHIDYWKAIRQENAIFFAARHQVVPALNICKAKACKAIEWNTEP KHCFKKGGQHIEVWFDYVAWDSVYYCGDDGWCKTEAEKYGCKGTWEVHFG NSIDCNDSMCSTFDDNVSATELVKDHIDYWKLIRLECAIFYKARRRLSSD QDQSQLVTKYPLLKLLSRPPNMGVKAHGKCIWENKVFIVPTLCPVPLDPT YPLLKLLTTQTTTPENTSLVELRVTTPKSTVVIRLHLTTRYPLLSLLNSY STPPHRIPAPCPWAPQRPPIPKPSPWAPRIPAPCPWAPPRPPHCPWVPPP PPPRPWAPCFLLCFCVLLCVCLLIRPLLLSVSTYLRPLLLSISVYAQVLV LVLLLWVSIGSLLPSVCMCAYAWVLVFVYIVVITSPATAIVYRDGNPYAV CDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINVVYRDSI PHAACHKCIDFYSRIRELRHYSDSVYGDTLEKLTNTGLYNLLIRCLRVFC KKALTASEVYNFAYTDLRVVYRDSKVRKLRYYNCSVYGASLVYCKGQLTE TEVLDFAFTDLTIVYRDSKVSEFRWYRYSVYGTTLCVECKKTLQRSEVYD CQRPLCPQEKKRHVDLNKRFHTLHEYMLDLQPETTDLYCYEQPETTDLHC YEQLGDSSDEEDTGGLDGDEDEDEVDHLQEQPQQARRDEQHPCYLIETQC CRCESLVEENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCEARIAGSGPG ASGKPIPNPLLGLDSTRT**
HPV3 Polypeptide Sequence without the TPA/Peptide Adjuvant Sequence (SEQ ID NO: 66)

(49) TABLE-US-00012 DEDETAYDSGTDL IDFIDDSDENENDSDTGEDMVDFIDNDETDEESTESDLDGFIDNSAQLAD SDSNACAFLKAQLADVNSNAAAFLKNCILLYGAANTGKSLFGMSLNCLVL CGPANTGKSYFGMSLNCLVIYGPPNIGKSCFAMSLWPYLHSRLVVETFPN PFWPYLESRITVFEFPNAFLRYLHSRIHVLQFLNPFNVCQDKILEHYEND SKDILEHYENDSKDLCDHICDHIDYWKHIRLECAIMYKARIRLECAIMYK AREMGFHQFDGDICNTMHYTNWIYICEDAQCTVVEGQVDKKWEVHAGGQV ILCPESGQRRIKRPRSENCHPNKLLILKCLRYRFKKHCKLSSTWHWTCHD GKHKWHWTCHDGKHKNAIVTLTYYEADKNDLNAQIEHWKLIRMECAIFYK AKELGISICHQVVPPLAASKAKACQAIELQLALEALNASPYDEWTLQQTS LEMWLAEPQFKKHGITITVQYDNDKANTMDYTNWKEIYVIVCPASIPSDE ISTEEADHIDYWKAIRQENAIFFAARHQVVPALNICKAKACKAIEWNTEP KHCFKKGGQHIEVWFDYVAWDSVYYCGDDGWCKTEAEKYGCKGTWEVHFG NSIDCNDSMCSTFDDNVSATELVKDHIDYWKLIRLECAIFYKARRRLSSD QDQSQLVTKYPLLKLLSRPPNMGVKAHGKCIWENKVFIVPTLCPVPLDPT YPLLKLLTTQTTTPENTSLVELRVTTPKSTVVIRLHLTTRYPLLSLLNSY STPPHRIPAPCPWAPQRPPIPKPSPWAPRIPAPCPWAPPRPPHCPWVPPP PPPRPWAPCFLLCFCVLLCVCLLIRPLLLSVSTYLRPLLLSISVYAQVLV LVLLLWVSIGSLLPSVCMCAYAWVLVFVYIVVITSPATAIVYRDGNPYAV CDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINVVYRDSI PHAACHKCIDEYSRIRELRHYSDSVYGDTLEKLTNTGLYNLLIRCLRVFC KKALTASEVYNFAYTDLRVVYRDSKVRKLRYYNCSVYGASLVYCKGQLTE TEVLDFAFTDLTIVYRDSKVSEFRWYRYSVYGTTLCVECKKTLQRSEVYD CQRPLCPQEKKRHVDLNKRFHTLHEYMLDLQPETTDLYCYEQPETTDLHC YEQLGDSSDEEDTGGLDGDEDEDEVDHLQEQPQQARRDEQHPCYLIETQC CRCESLVEENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCEARIAGSGPG ASGKPIPNPLLGLDSTRT**
Viral Vector Sequence ChAdOx1 with Immunogen Coding Sequence Insert.

(50) Start and end codons of the immunogen coding sequence insert are underlined. Lead TPA sequence and linker is in bold.

(51) TABLE-US-00013 (SEQ ID NO: 62) GTTTAAACGCGGCCGCCAGGCCTACCCACTAGTCAATTCGGGAGGATCGAAACGGCAGATCGCAA AAAACAGTACATACAGAAGGAGACATGAACATGAACATCAAAAAAATTGTAAAACAAGCCACAGT TCTGACTTTTACGACTGCACTTCTGGCAGGAGGAGCGACTCAAGCCTTCGCGAAAGAAAATAACC AAAAAGCATACAAAGAAACGTACGGCGTCTCTCATATTACACGCCATGATATGCTGCAGATCCCT AAACAGCAGCAAAACGaAAAATACCAAGTGCCTCAATTCGATCAATCAACGATTAAAAATATTGA GTCTGCAAAAGGACTTGATGTGTGGGACAGCTGGCCGCTGCAAAACGCTGACGGAACAGTAGCTG AATACAACGGCTATCACGTTGTGTTTGCTCTTGCGGGAAGCCCGAAAGACGCTGATGACACATCA ATCTACATGTTTTATCAAAAGGTCGGCGACAACTCAATCGACAGCTGGAAAAACGCGGGCCGTGT CTTTAAAGACAGCGATAAGTTCGACGCCAACGATCCGATCCTGAAAGATCAGACGCAAGAATGGT CCGGTTCTGCAACCTTTACATCTGACGGAAAAATCCGTTTATTCTACACTGACTATTCCGGTAAA CATTACGGCAAACAAAGCCTGACAACAGCGCAGGTAAATGTGTCAAAATCTGATGACACACTCAA AATCAACGGAGTGGAAGATCACAAAACGATTTTTGACGGAGACGGAAAAACATATCAGAACGTTC AGCAGTTTATCGATGAAGGCAATTATACATCCGGCGACAACCATACGCTGAGAGACCCTCACTAC GTTGAAGACAAAGGCCATAAATACCTTGTATTCGAAGCCAACACGGGAACAGAAAACGGATACCA AGGCGAAGAATCTTTATTTAACAAAGCGTACTACGGCGGCGGCACGAACTTCTTCCGTAAAGAAA GCCAGAAGCTTCAGCAGAGCGCTAAAAAACGCGATGCTGAGTTAGCGAACGGCGCCCTCGGTATC ATAGAGTTAAATAATGATTACACATTGAAAAAAGTAATGAAGCCGCTGATCACTTCAAACACGGT AACTGATGAAATCGAGCGCGCGAATGTTTTCAAAATGAACGGCAAATGGTACTTGTTCACTGATT CACGCGGTTCAAAAATGACGATCGATGGTATTAACTCAAACGATATTTACATGCTTGGTTATGTA TCAAACTCTTTAACCGGCCCTTACAAGCCGCTGAACAAAACAGGGCTTGTGCTGCAAATGGGTCT TGATCCAAACGATGTGACATTCACTTACTCTCACTTCGCAGTGCCGCAAGCCAAAGGCAACAATG TGGTTATCACAAGCTACATGACAAACAGAGGCTTCTTCGAGGATAAAAAGGCAACATTTGCGCCA AGCTTCTTAATGAACATCAAAGGCAATAAAACATCCGTTGTCAAAAACAGCATCCTGGAGCAAGG ACAGCTGACAGTCAACTAATAACAGCAAAAAGaAAATGCCGATACTTCATTGGCATTTTCTTtTA TTTCTCAACAAGATGGTGAATTGACTAGTGGGTAGATCCACAGGACGGGTGTGGTCGCCATGATC GCGTAGTCGATAGTGGCTCCAAGTAGCGAAGCGAGCAGGACTGGGCGGCGGCCAAAGCGGTCGGA CAGTGCTCCGAGAACGGGTGCGCATAGAAATTGCATCAACGCATATAGCGCTAGCAGCACGCCAT AGTGACTGGCGATGCTGTCGGAATGGACGATATCCCGCAAGAGGCCCGGCAGTACCGGCATAACC AAGCCTATGCCTACAGCATCCAGGGTGACGGTGCCGAGGATGACGATGAGCGCATTGTTAGATTT CATACACGGTGCCTGACTGCGTTAGCAATTTAACTGTGATAAACTACCGCATTAAAGCTTATCGA TGATAAGCTGTCAAACATGAGAATTGATCCGGAACCCTTAATATAACTTCGTATAATGTATGCTA TACGAAGTTATTAGGTCCCTCGACTATAGGGTCACCGTCGACAGCGACACACTTGCATCGGATGC AGCCCGGTTAACGTGCCGGCACGGCCTGGGTAACCAGGTATTTTGTCCACATAACCGTGCGCAAA ATGTTGTGGATAAGCAGGACACAGCAGCAATCCACAGCAGGCATACAACCGCACACCGAGGTTAC TCCGTTCTACAGGTTACGACGACATGTCAATACTTGCCCTTGACAGGCATTGATGGAATCGTAGT CTCACGCTGATAGTCTGATCGACAATACAAGTGGGACCGTGGTCCCAGACCGATAATCAGACCGA CRAYACGAGTGGGAYCGTGGTCCCAGACTAATAATCAGACCGACGATACGAGTGGGACCGTGGTC CCAGACTAATAATCAGACCGACGATACGAGTGGGACCGTGGTYCCAGWCTRATWATCAGACCGAC GATACRAGTGGRACMGTGGKCCCAGASAKAATAWTCAGRCCgAGWTAYGcWKTCKGGCCTGTAAC AAAGGACATTAAGTAAAGACAGATAMRMGTgRGACtaaaaCGTGGTCCCAGTCTGATTATCAGAC CGACGATACGAGTGGGACCGTGGTCCCAGACTAATAATCAGACCGACGATACGAGTGGGACCGTG GTCCCAGACTAATAATCAGACCGACGATACGAGTGGGACCGTGGTCCCAGTCTGATTATCAGACC GACGATACAAGTGGAACAGTGGGCCCAGAGAGAATATTCAGGCCAGTTATGCTTTCTGGCCTGTA ACAAAGGACATTAAGTAAAGACAGATAAACGTAGACTAAAACGTGGTCGCATCAGGGTGCTGGCT TTTCAAGTTCCTTAAGAATGGCCTCAATTTTCTCTATACACTCAGTTGGAACACGAGACCTGTCC AGGTTAAGCACCATTTTATCGCCCTTATACAATACTGTCGCTCCAGGAGCAAACTGATGTCGTGA GCTTAAACTAGTTCTTGATGCAGATGACGTTTTAAGCACAGAAGTTAAAAGAGTGATAACTTCTT CAGCTTCAAATATCACCCCAGCTTTTTTCTGCTCATGAAGGTTAGATGCCTGCTGCTTAAGTAAT TCCTCTTTATCTGTAAAGGCTTTTTGAAGTGCATCACCTGACCGGGCAGATAGTTCACCGGGGTG AGAAAAAAGAGCAACAACTGATTTAGGCAATTTGGCGGTGTTGATACAGCGGGTAATAATCTTAC GTGAAATATTTTCCGCATCAGCCAGCGCAGAAATATTTCCAGCAAATTCATTCTGCAATCGGCTT GCATAACGCTGACCACGTTCATAAGCACTTGTTGGGCGATAATCGTTACCCAATCTGGATAATGC AGCCATCTGCTCATCATCCAGCTCGCCAACCAGAACACGATAATCACTTTCGGTAAGTGCAGCAG CTTTACGACGGCGACTCCCATCGGCAATTTCTATGACACCAGATACTCTTCGACCGAACGCCGGT GTCTGTTGACCAGTCAGTAGAAAAGAAGGGATGAGATCATCCAGTGCGTCCTCAGTAAGCAGCTC CTGGTCACGTTCATTACCTGACCATACCCGAGAGGTCTTCTCAACACTATCACCCCGGAGCACTT CAAGAGTAAACTTCACATCCCGACCACATACAGGCAAAGTAATGGCATTACCGCGAGCCATTACT CCTACGCGCGCAATTAACGAATCCACCATCGGGGCAGCTGGTGTCGATAACGAAGTATCTTCAAC CGGTTGAGTATTGAGCGTATGTTTTGGAATAACAGGCGCACGCTTCATTATCTAATCTCCCAGCG TGGTTTAATCAGACGATCGAAAATTTCATTGCAGACAGGTTCCCAAATAGAAAGAGCATTTCTCC AGGCACCAGTTGAAGAGCGTTGATCAATGGCCTGTTCAAAAACAGTTCTCATCCGGATCTGACCT TTACCAACTTCATCCGTTTCACGTACAACATTTTTTAGAACCATGCTTCCCCAGGCATCCCGAAT TTGCTCCTCCATCCACGGGGACTGAGAGCCATTACTATTGCTGTATTTGGTAAGCAAAATACGTA CATCAGGCTCGAACCCTTTAAGATCAACGTTCTTGAGCAGATCACGAAGCATATCGAAAAACTGC AGTGCGGAGGTGTAGTCAAACAACTCAGCAGGCGTGGGAACAATCAGCACATCAGCAGCACATAC GACATTAATCGTGCCGATACCCAGGTTAGGCGCGCTGTCAATAACTATGACATCATAGTCATGAG CAACAGTTTCAATGGCCAGTCGGAGCATCAGGTGTGGATCGGTGGGCAGTTTACCTTCATCAAAT TTGCCCATTAACTCAGTTTCAATACGGTGCAGAGCCAGACAGGAAGGAATAATGTCAAGCCCCGG CCAGCAAGTGGGCTTTATTGCATAAGTGACATCGTCCTTTTCCCCAAGATAGAAAGGCAGGAGAG TGTCTTCTGCATGAATATGAAGATCTGGTACCCATCCGTGATACATTGAGGCTGTTCCCTGGGGG TCGTTACCTTCCACGAGCAAAACACGTAGCCCCTTCAGAGCCAGATCCTGAGCAAGATGAACAGA AACTGAGGTTTTGTAAACGCCACCTTTATGGGCAGCAACCCCGATCACCGGTGGAAATACGTCTT CAGCACGTCGCAATCGCGTACCAAACACATCACGCATATGATTAATTTGTTCAATTGTATAACCA ACACGTTGCTCAACCCGTCCTCGAATTTCCATATCCGGGTGCGGTAGTCGCCCTGCTTTCTCGGC ATCTCTGATAGCCTGAGAAGAAACCCCAACTAAATCCGCTGCTTCACCTATTCTCCAGCGCCGGG TTATTTTCCTCGCTTCCGGGCTGTCATCATTAAACTGTGCAATGGCGATAGCCTTCGTCATTTCA TGACCAGCGTTTATGCACTGGTTAAGTGTTTCCATGAGTTTCATTCTGAACATCCTTTAATCATT GCTTTGCGTTTTTTTATTAAATCTTGCAATTTACTGCAAAGCAACAACAAAATCGCAAAGTCATC AAAAAACCGCAAAGTTGTTTAAAATAAGAGCAACACTACAAAAGGAGATAAGAAGAGCACATACC TCAGTCACTTATTATCACTAGCGCTCGCCGCAGCCGTGTAACCGAGCATAGCGAGCGAACTGGCG AGGAAGCAAAGAAGAACTGTTCTGTCAGATAGCTCTTACGCTCAGCGCAAGAAGAAATATCCACC GTGGGAAAAACTCCAGGTAGAGGTACACACGCGGATAGCCAATTCAGAGTAATAAACTGTGATAA TCAACCCTCATCAATGATGACGAACTAACCCCCGATATCAGGTCACATGACGAAGGGAAAGAGAA GGAAATCAACTGTGACAAACTGCCCTCAAATTTGGCTTCCTTAAAAATTACAGTTCAAAAAGTAT GAGAAAATCCATGCAGGCTGAAGGAAACAGCAAAACTGTGACAAATTACCCTCAGTAGGTCAGAA CAAATGTGACGAACCACCCTCAAATCTGTGACAGATAACCCTCAGACTATCCTGTCGTCATGGAA GTGATATCGCGGAAGGAAAATACGATATGAGTCGTCTGGCGGCCTTTCTTTTTCTCAATGTATGA GAGGCGCATTGGAGTTCTGCTGTTGATCTCATTAACACAGACCTGCAGGAAGCGGCGGCGGAAGT CAGGCATACGCTGGTAACTTTGAGGCAGCTGGTAACGCTCTATGATCCAGTCGATTTTCAGAGAG ACGATGCCTGAGCCATCCGGCTTACGATACTGACACAGGGATTCGTATAAACGCATGGCATACGG ATTGGTGATTTCTTTTGTTTCACTAAGCCGAAACTGCGTAAACCGGTTCTGTAACCCGATAAAGA AGGGAATGAGATATGGGTTGATATGTACACTGTAAAGCCCTCTGGATGGACTGTGCGCACGTTTG ATAAACCAAGGAAAAGATTCATAGCCTTTTTCATCGCCGGCATCCTCTTCAGGGCGATaAAAAAC CACTTCCTTCCCCGCGAAACTCTTCAATGCCTGCCGTATATCCTTACTGGCTTCCGCAGAGGTCA ATCCGAATATTTCAGCATATTTAGCAACATGGATCTCGCAGATACCGTCATGTTCCTGTAGGGTG CCATCAGATTTTCTGATCTGGTCAACGAACAGATACAGCATACGTTTTTGATCCCGGGAGAGACT ATATGCCGCCTCAGTGAGGTCGTTTGACTGGACGATTCGCGGGCTATTTTTACGTTTCTTGTGAT TGATAACCGCTGTTTCCGCCATGACAGATCCATGTGAAGTGTGACAAGTTTTTAGATTGTCACAC TAAATAAAAAAGAGTCAATAAGCAGGGATAACTTTGTGAAAAAACAGCTTCTTCTGAGGGCAATT TGTCACAGGGTTAAGGGCAATTTGTCACAGACAGGACTGTCATTTGAGGGTGATTTGTCACACTG AAAGGGCAATTTGTCACAACACCTTCTCTAGAACCAGCATGGATAAAGGCCTACAAGGCGCTCTA AAAAAGAAGATCTAAAAACTATaAAAAAAATAATTATAAAAATATCCCCGTGGATAAGTGGATAA CCCCAAGGGAAGTTTTTtCAGGCATCGTGTGTAAGCAGAATATATAAGTGCTGTTCCCTGGTGCT TCCTCGCTCACTCGAGGGCTTCGCCCTGTCGCTCAACTGCGGCGAGCACTACTGGCTGTAAAAGG ACAGACCACATCATGGTTCTGTGTTCATTAGGTTGTTCTGTCCATTGCTGACATAATCCGCTCCA CTTCAACGTAACACCGCACGAAGATTTCTATTGTTCCTGAAGGCATATTCAAATCGTTTTCGTTA CCGCTTGCAGGCATCATGACAGAACACTACTTCCTATAAACGCTACACAGGCTCCTGAGATTAAT AATGCGGATCTCTACGATAATGGGAGATTTTCCCGACTGTTTCGTTCGCTTCTCAGTGGATAACA GCCAGCTTCTCTGTTTAACAGACAAAAACAGCATATCCACTCAGTTCCACATTTCCATATAAAGG CCAAGGCATTTATTCTCAGGATAATTGTTTCAGCATCGCAACCGCATCAGACTCCGGCATCGCAA ACTGCACCCGGTGCCGGGCAGCCACATCCAGCGCAAAAACCTTCGTGTAGACTTCCGTTGAACTG ATGGACTTATGTCCCATCAGGCTTTGCAGAACTTTCAGCGGTATACCGGCATACAGCATGTGCAT CGCATAGGAATGGCGGAACGTATGTGGTGTGACCGGAACAGAGAACGTCACACCGTCAGCAGCAG CGGCGGCAACCGCCTCCCCAATCCAGGTCCTGACCGTTCTGTCCGTCACTTCCCAGATCCGCGCT TTCTCTGTCCTTCCTGTGCGACGGTTACGCCGCTCCATGAGCTTATCGCGAATAAATACCTGTGA CGGAAGATCACTTCGCAGAATAAATAAATCCTGGTGTCCCTGTTGATACCGGGAAGCCCTGGGCC AACTTTTGGCGAAAATGAGACGTTGATCGGCACGTAAGAGGTTCCAACTTTCACCATAATGAAAT AAGATCACTACCGGGCGTATTTTTTGAGTTATCGAGATTTTCAGGAGCTAAGGAAGCTAAAATGG AGAAAAAAATCACTGGATATACCACCGTTGATATATCCCAATGGCATCGTAAAGAACATTTTGAG GCATTTCAGTCAGTTGCTCAATGTACCTATAACCAGACCGTTCAGCTGGATATTACGGCCTTTTT AAAGACCGTAAAGAAAAATAAGCACAAGTTTTATCCGGCCTTTATTCACATTCTTGCCCGCCTGA TGAATGCTCATCCGGAGTTCCGTATGGCAATGAAAGACGGTGAGCTGGTGATATGGGATAGTGTT CACCCTTGTTACACCGTTTTCCATGAGCAAACTGAAACGTTTTCATCGCTCTGGAGTGAATACCA CGACGATTTCCGGCAGTTTCTACACATATATTCGCAAGATGTGGCGTGTTACGGTGAAAACCTGG CCTATTTCCCTAAAGGGTTTATTGAGAATATGTTTTTCGTCTCAGCCAATCCCTGGGTGAGTTTC ACCAGTTTTGATTTAAACGTGGCCAATATGGACAACTTCTTCGCCCCCGTTTTCACCATGGGCAA ATATTATACGCAAGGCGACAAGGTGCTGATGCCGCTGGCGATTCAGGTTCATCATGCCGTTTGTG ATGGCTTCCATGTCGGCAGAATGCTTAATGAATTACAACAGTACTGCGATGAGTGGCAGGGCGGG GCGTAAtTTTTTTAAGGCAGTTATTGGTGCCCTTAAACGCCTGGTTGCTACGCCTGAATAAGTGA TAATAAGCGGATGAATGGCAGAAATTCGATGATAAGCTGTCAAACATGAGAATTGGTCGACGGCG CGCCAAAGCTTGCATGCCTGCAGCCGCGTAACCTGGCAAAATCGGTTACGGTTGAGTAATAAATG GATGCCCTGCGTAAGCGGGGCACATTTCATTACCTCTTTCTCCGCACCCGACATAGATAATAACT TCGTATAGTATACATTATACGAAGTTATCTAGTAGACTTAATCGCGTTTAAACCCATCATCAATA ATATACCTCAAACTTTTTGTGCGCGTTAATATGCAAATGAGGCGTTTGAATTTGGGAAGGGAGGA AGGTGATTGGCCGAGAGAAGGGCGACCGTTAGGGGCGGGGCGAGTGACGTTTTGATGACGTGACC GCGAGGAGGAGCCAGTTTGCAAGTTCTCGTGGGAAAAGTGACGTCAAACGAGGTGTGGTTTGAAC ACGGAAATACTCAATTTTCCCGCGCTCTCTGACAGGAAATGAGGTGTTTCTAGGCGGATGCAAGT GAAAACGGGCCATTTTCGCGCGAAAACTGAATGAGGAAGTGAAAATCTGAGTAATTTCGCGTTTA TGACAGGGAGGAGTATTTGCCGAGGGCCGAGTAGACTTTGACCGATTACGTGGGGGTTTCGATTA CCGTGTTTTTCACCTAAATTTCCGCGTACGGTGTCAAAGTCCGGTGTTTTTACGTAGGTGTCAGC TGATCGCCAGGGTATTTAAACCTGCGCTCTCCAGTCAAGAGGCCACTCTTGAGTGCCAGCGAGAA GAGTTTTCTCCTCCGCGCGCGAGTCAGATCTACACTTTGAAAGGCGATCGCTAGCGACATCGATC ACAAGTTTGTACAAAAAAGCAGGCTCCACCATGGGAACCAATTCAgTCGAGCCTTTCACTCATTA GATGCATGTCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCC CATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAA TGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTAC GCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTAT GGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTT TGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCAT TGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACT CCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTC CCTATCAGTGATAGAGATCTCCCTATCAGTGATAGAGATCGTCGACGAGCTCGTTTAGTGAACCG TCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCA GCCTCCGGTTAAGCTcGgtacCGCTAGCCGCGCCGCCACCATGGATGCTATGAAGAGGGGCCTGT GCTGCGTGCTGCTGCTGTGTGGCGCCGTGTTTGTGTCCCCCAGCCAGGAAATCCACGCCCGGTTC AGAAGAGGCAGCAAGCTGGCCGACGAGGACGAGACAGCCTACGACAGCGGCACCGACCTGATCGA CTTCATCGACGACAGCGACGAGAATGAGAACGACTCCGACACCGGCGAGGACATGGTGGATTTCA TCGACAACGACGAAACCGACGAAGAGAGCACCGAGAGCGACCTGGACGGCTTTATCGACAACTCC GCCCAGCTGGCTGACAGCGACAGCAATGCCTGCGCCTTCCTGAAGGCTCAGCTGGCAGACGTGAA CAGCAACGCCGCTGCTTTTCTGAAGAACTGCATCCTGCTGTACGGCGCTGCCAACACCGGCAAGA GCCTGTTCGGCATGAGCCTGAACTGCCTGGTGCTGTGCGGCCCAGCCAATACCGGAAAGTCCTAC TTCGGCATGTCCCTGAATTGTCTCGTGATCTACGGCCCACCTAACACAGGCAAGTCCTGCTTTGC CATGTCTCTGTGGCCCTACCTGCACAGCAGACTGGTGGTGTTTACCTTCCCCAACCCCTTCTGGC CTTACCTGGAAAGCCGGATCACCGTGTTCGAGTTCCCCAATGCCTTTCTGAGATACCTGCACTCC CGGATCCACGTGCTGCAGTTTCTGAACCCCTTCAACGTGTGCCAGGACAAGATCCTGGAACACTA CGAGAACGACAGCAAGGACATTCTGGAACATTATGAGAATGATTCCAAGGACCTGTGCGACCACA TCTGCGATCACATCGACTACTGGAAGCACATCCGGCTGGAATGCGCCATCATGTACAAGGCCCGG ATCAGACTGGAATGTGCTATTATGTATAAGGCTCGCGAGATGGGCTTCCACCAGTTCGACGGCGA CATCTGCAACACCATGCACTACACCAACTGGATCTATATCTGCGAGGACGCCCAGTGCACCGTGG TGGAAGGCCAGGTGGACAAGAAATGGGAGGTGCACGCTGGCGGCCAAGTGATCCTGTGTCCTGAG AGCGGCCAGCGGCGGATCAAGAGGCCCAGAAGCGAGAACTGCCACCCCAACAAGCTGCTGATCCT GAAGTGCCTGCGGTACAGATTCAAGAAGCACTGCAAGCTGAGCAGCACCTGGCACTGGACCTGCC ACGACGGCAAGCACAAGTGGCATTGGACATGTCACGATGGGAAACACAAGAACGCCATTGTGACC CTGACCTACTACGAGGCCGACAAGAACGACCTGAACGCCCAGATCGAGCACTGGAAACTGATCCG GATGGAATGTGCAATCTTCTATAAGGCCAAAGAGCTGGGCATCAGCATCTGCCACCAGGTGGTGC CTCCACTGGCCGCCTCTAAAGCCAAAGCCTGCCAGGCCATCGAACTGCAGCTGGCCCTGGAAGCC CTGAATGCCAGCCCCTACGATGAGTGGACCCTGCAGCAGACCAGCCTGGAAATGTGGCTGGCCGA GCCCCAGTTTAAGAAGCACGGCATCACCATCACCGTGCAGTACGACAATGACAAGGCCAATACCA TGGATTACACAAATTGGAAAGAAATCTACGTGATCGTGTGCCCCGCCAGCATCCCCTCCGATGAG ATCAGCACCGAGGAAGCCGACCACATTGATTATTGGAAAGCCATCAGGCAGGAAAACGCCATCTT CTTCGCCGCCAGACACCAGGTGGTGCCCGCCCTGAATATCTGCAAGGCCAAGGCCTGTAAAGCCA TCGAGTGGAACACCGAGCCCAAGCACTGCTTCAAGAAGGGCGGCCAGCACATCGAAGTGTGGTTC GACTACGTGGCCTGGGACAGCGTGTACTACTGCGGCGACGATGGCTGGTGCAAGACCGAGGCCGA GAAGTACGGCTGCAAGGGCACCTGGGAAGTGCATTTCGGCAACAGCATCGACTGCAACGACTCCA TGTGCAGCACCTTCGACGACAACGTGTCCGCCACCGAGCTCGTGAAGGACCATATCGACTATTGG AAGCTGATTCGCCTGGAATGTGCCATTTTTTACAAGGCCAGACGGCGGCTGTCCAGCGACCAGGA TCAGTCTCAGCTCGTGACCAAGTACCCCCTGCTGAAGCTGCTGTCCAGACCCCCCAACATGGGCG TGAAGGCCCACGGCAAGTGCATCTGGGAGAACAAGGTGTTCATCGTGCCCACCCTGTGCCCCGTG CCTCTGGATCCAACATATCCTCTGCTGAAACTGCTGACCACCCAGACCACCACCCCCGAGAATAC CTCCCTGGTGGAACTGAGAGTGACCACCCCCAAGAGCACAGTCGTGATCAGGCTGCACCTGACCA CCAGATACCCACTGCTGTCACTGCTGAACAGCTACAGCACCCCCCCTCACCGGATCCCTGCTCCA TGTCCTTGGGCTCCTCAGAGGCCCCCCATCCCTAAGCCTTCTCCATGGGCCCCTAGAATCCCTGC CCCTTGCCCCTGGGCACCTCCTAGACCTCCACACTGTCCATGGGTGCCCCCTCCACCTCCTCCAA GACCTTGGGCCCCTTGCTTCCTGCTGTGCTTTTGTGTGCTGCTGTGCGTGTGCCTGCTGATCAGA CCCCTGCTGCTGAGTGTGTCCACCTACCTGAGGCCTCTGCTGCTGTCTATCAGCGTGTACGCTCA GGTGCTGGTGCTGGTGCTGCTGCTGTGGGTGTCCATCGGAAGCCTGCTGCCCAGCGTGTGCATGT GTGCCTATGCCTGGGTGCTGGTGTTCGTGTACATCGTCGTGATTACCAGCCCCGCCACCGCCATC GTGTACCGGGATGGCAATCCTTACGCCGTGTGCGACAAGTGCCTGAAGTTCTACAGCAAGATCAG CGAGTACCGGCACTACTGCTACAGCCTGTACGGCACCACCCTGGAACAGCAGTACAACAAGCCCC TGTGCGATCTGCTGATTCGGTGCATCAACGTGGTGTACAGAGACTCCATCCCCCACGCCGCCTGC CACAAGTGTATCGACTTCTACTCCAGAATCAGAGAGCTGCGGCACTACAGCGACTCCGTGTACGG CGATACCCTGGAAAAGCTGACCAACACTGGCCTGTACAACCTGCTGATTAGATGCCTGCGGGTGT TCTGCAAGAAGGCCCTGACAGCCAGCGAGGTGTACAACTTCGCCTACACCGATCTGCGGGTGGTG TATCGGGACAGCAAAGTGCGGAAGCTGAGGTACTACAACTGCTCTGTGTATGGCGCCAGCCTGGT GTATTGCAAGGGACAGCTGACCGAGACAGAGGTGCTGGATTTCGCCTTCACAGACCTGACAATCG TGTATCGCGACTCCAAGGTGTCCGAGTTCCGGTGGTACAGATATTCCGTGTATGGCACCACACTG TGCGTGGAATGCAAGAAAACCCTGCAGAGATCTGAGGTGTACGACTGCCAGCGGCCACTGTGTCC GCAGGAAAAGAAAAGACACGTGGACCTGAACAAGCGGTTCCACACCCTGCACGAGTACATGCTGG ATCTGCAGCCCGAGACAACCGACCTGTACTGCTACGAGCAGCCTGAAACCACTGATCTGCACTGT TATGAGCAGCTGGGAGACAGCTCCGATGAAGAGGACACTGGCGGCCTGGATGGGGACGAGGATGA GGACGAAGTGGACCATCTGCAGGAACAGCCCCAGCAGGCTAGACGGGACGAACAGCACCCTTGCT ATCTGATCGAGACACAGTGCTGCAGATGCGAATCTCTGGTGGAAGAGAACGACGAGATCGACGGC GTGAACCACCAGCATCTGCCCGCTAGAAGGGCCGAGCCTCAGAGACACACCATGCTGTGTATGTG CTGCAAGTGCGAGGCCAGAATCGCCGGCTCTGGACCTGGCGCCTCTGGCAAGCCTATCCCCAATC CACTGCTGGGCCTGGACTCCACCCGGACCTGATAAGCggccgctcgagcatgcatctagagggcc ctattctatagtgtcacctaaatgctagagctcgctgatcagcctcgactgtgccttctagttgc cagccatctgttgtttgcccctcccccgtgccttccttgaccctggaaggtgccactcccactgt cctttcctaataaaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctggggg gtggggtggggcaggacagcaagggggaggattgggaagacaatagcaggcatgctggggatgcg gtgggctctatggcttctgaggcggaaagaaccagctggggctcgaggggggatcgatcccgtcG AGATATCTAGACCCAGCTTTCTTGTACAAAGTGGTGATCGATTCGACAGATCGCGATCGCAGTGA GTAGTGTTCTGGGGCGGGGGAGGACCTGCATGAGGGCCAGAATGACTGAAATCTGTGCTTTTCTG TGTGTTGCAGCATCATGAGCGGAAGCGGCTCCTTTGAGGGAGGGGTATTCAGCCCTTATCTGACG GGGCGTCTCCCCTCCTGGGCGGGAGTGCGTCAGAATGTGATGGGATCCACGGTGGACGGCCGGCC CGTGCAGCCCGCGAACTCTTCAACCCTGACCTATGCAACCCTGAGCTCTTCGTCGGTGGACGCAG CTGCCGCCGCAGCTGCTGCATCCGCCGCCAGCGCCGTGCGCGGAATGGCCATGGGCGCCGGCTAC TACGGCACTCTGGTGGCCAACTCGAGTTCCACCAATAATCCCGCCAGCCTGAACGAGGAGAAGCT GCTGCTGCTGATGGCCCAGCTTGAGGCCTTGACCCAGCGCCTGGGCGAGCTGACCCAGCAGGTGG CTCAGCTGCAGGAGCAGACGCGGGCCGCGGTTGCCACGGTGAAATCCAAATAAAAAATGAATCAA TAAATAAACGGAGACGGTTGTTGATTTTAACACAGAGTCTGAATCTTTATTTGATTTTTCGCGCG CGGTAGGCCCTGGACCACCGGTCTCGATCATTGAGCACCCGGTGGATCTTTTCCAGGACCCGGTA GAGGTGGGCTTGGATGTTGAGGTACATGGGCATGAGCCCGTCCCGGGGGTGGAGGTAGCTCCATT GCAGGGCCTCGTGCTCGGGGGTGGTGTTGTAAATCACCCAGTCATAGCAGGGGCGCAGGGCGTGG TGTTGCACAATATCTTTGAGGAGGAGACTGATGGCCACGGGCAGCCCTTTGGTGTAGGTGTTTAC AAATCTGTTGAGCTGGGAGGGATGCATGCGGGGGGAGATGAGGTGCATCTTGGCCTGGATCTTGA GATTGGCGATGTTACCGCCCAGATCCCGCCTGGGGTTCATGTTGTGCAGGACCACCAGCACGGTG TATCCGGTGCACTTGGGGAATTTATCATGCAACTTGGAAGGGAAGGCGTGAAAGAATTTGGCGAC GCCCTTGTGTCCGCCCAGGTTTTCCATGCACTCATCCATGATGATGGCAATGGGCCCGTGGGCGG CGGCCTGGGCAAAGACGTTTCGGGGGTCGGACACATCATAGTTGTGGTCCTGGGTGAGGTCATCA TAGGCCATTTTAATGAATTTGGGGCGGAGGGTGCCGGACTGGGGGACAAAGGTACCCTCGATCCC GGGGGCGTAGTTCCCCTCACAGATCTGCATCTCCCAGGCTTTGAGCTCAGAGGGGGGGATCATGT CCACCTGCGGGGCGATAAAGAACACGGTTTCCGGGGCGGGGGAGATGAGCTGGGCCGAAAGCAAG TTCCGGAGCAGCTGGGACTTGCCGCAGCCGGTGGGGCCGTAAATGACCCCGATGACCGGCTGCAG GTGGTAGTTGAGGGAGAGACAGCTGCCGTCCTCCCGGAGGAGGGGGGCCACCTCGTTCATCATCT CGCGCACGTGCATGTTCTCGCGCACCAGTTCCGCCAGGAGGCGCTCTCCCCCCAGAGATAGGAGC TCCTGGAGCGAGGCGAAGTTTTTCAGCGGCTTGAGTCCGTCGGCCATGGGCATTTTGGAGAGGGT CTGTTGCAAGAGTTCCAAGCGGTCCCAGAGCTCGGTGATGTGCTCTACGGCATCTCGATCCAGCA GACCTCCTCGTTTCGCGGGTTGGGACGACTGCGGGAGTAGGGCACCAGACGATGGGCGTCCAGCG CAGCCAGGGTCCGGTCCTTCCAGGGCCGCAGCGTCCGCGTCAGGGTGGTCTCCGTCACGGTGAAG GGGTGCGCGCCGGGCTGGGCGCTTGCGAGGGTGCGCTTCAGGCTCATCCGGCTGGTCGAAAACCG CTCCCGATCGGCGCCCTGCGCGTCGGCCAGGTAGCAATTGACCATGAGTTCGTAGTTGAGCGCCT CGGCCGCGTGGCCTTTGGCGCGGAGCTTACCTTTGGAAGTCTGCCCGCAGGCGGGACAGAGGAGG GACTTGAGGGCGTAGAGCTTGGGGGCGAGGAAGACGGAATCGGGGGCGTAGGCGTCCGCGCCGCA GTGGGCGCAGACGGTCTCGCACTCCACGAGCCAGGTGAGGTCGGGCTGGTCGGGGTCAAAAACCA GTTTCCCGCCGTTCTTTTTGATGCGTTTCTTACCTTTGGTCTCCATGAGCTCGTGTCCCCGCTGG GTGACAAAGAGGCTGTCCGTGTCCCCGTAGACCGACTTTATGGGCCGGTCCTCGAGCGGTGTGCC GCGGTCCTCCTCGTAGAGGAACCCCGCCCACTCCGAGACGAAAGCCCGGGTCCAGGCCAGCACGA AGGAGGCCACGTGGGACGGGTAGCGGTCGTTGTCCACCAGCGGGTCCACTTTTTCCAGGGTATGC AAACACATGTCCCCCTCGTCCACATCCAGGAAGGTGATTGGCTTGTAAGTGTAGGCCACGTGACC GGGGGTCCCGGCCGGGGGGGTATAAAAGGGGGCGGGCCCCTGCTCGTCCTCACTGTCTTCCGGAT CGCTGTCCAGGAGCGCCAGCTGTTGGGGTAGGTATTCCCTCTCGAAGGCGGGCATGACCTCGGCA CTCAGGTTGTCAGTTTCTAGAAACGAGGAGGATTTGATATTGACGGTGCCAGCGGAGATGCCTTT CAAGAGCCCCTCGTCCATCTGGTCAGAAAAGACGAtTTTTTTGTTGTCGAGCTTGGTGGCGAAGG AGCCGTAGAGGGCGTTGGAAAGGAGCTTGGCGATGGAGCGCATGGTCTGGTTTTTTtCCTtGTCG GCGCGCTCCTTGGCCGCGATGTTGAGCTGCACGTACTCGCGCGCCACGCACTTCCATTCGGGGAA GACGGTGGTCATCTCGTCGGGCACGATTCTGACCTGCCAACCTCGATTATGCAGGGTGATGAGGT CCACACTGGTGGCCACCTCGCCGCGCAGGGGCTCGTTGGTCCAGCAGAGGCGGCCGCCCTTGCGC GAGCAGAAGGGGGGCAGAGGGTCCAGCATGACCTCGTCGGGGGGGTCGGCATCGATGGTGAAGAT GCCGGGCAGGAGATCGGGGTCGAAGTAGCTGATGGAAGTGGCCAGATCGTCCAGGGAAGCTTGCC ATTCGCGCACGGCCAGCGCGCGCTCGTAGGGACTGAGGGGCGTGCCCCAGGGCATGGGGTGGGTG AGCGCGGAGGCGTACATGCCGCAGATGTCGTAGACGTAGAGGGGCTCCTCGAGGATGCCGATGTA GGTGGGGTAGCAGCGCCCCCCGCGGATGCTGGCGCGCACGTAGTCATACAGCTCGTGCGAGGGCG CGAGGAGCCCCGGGCCCAGGTTGGTGCGACTGGGCTTTTCGGCGCGGTAGACGATCTGGCGAAAG ATGGCATGCGAGTTGGAGGAGATGGTGGGCCTTTGGAAGATGTTGAAGTGGGCGTGGGGGAGGCC GACCGAGTCGCGGATGAAGTGGGCGTAGGAGTCTTGCAGTTTGGCGACGAGCTCGGCGGTGACGA GGACGTCCAGAGCGCAGTAGTCGAGGGTCTCCTGGATGATGTCATACTTGAGCTGGCCCTTTTGT TTCCACAGCTCGCGGTTGAGAAGGAACTCTTCGCGGTCCTTCCAGTACTCTTCGAGGGGGAACCC GTCCTGATCTGCACGGTAAGAGCCTAGCATGTAGAACTGGTTGACGGCCTTGTAGGCGCAGCAGC CCTTCTCCACGGGGAGGGCGTAGGCCTGGGCGGCCTTGCGCAGGGAGGTGTGCGTGAGGGCGAAG GTGTCCCTGACCATGACCTTGAGGAACTGGTGCTTGAAATCGATATCGTCGCAGcCCCCCTGCTC CCAGAGCTGGAAGTCCGTGCGCTTCTTGTAGGCGGGGTTGGGCAAAGCGAAAGTAACATCGTTGA AAAGGATCTTGCCCGCGCGGGGCATAAAGTTGCGAGTGATGCGGAAAGGCTGGGGCACCTCGGCC CGGTTGTTGATGACCTGGGCGGCGAGCACGATCTCGTCGAAACCGTTGATGTTGTGGCCCACGAT GTAGAGTTCCACGAATCGCGGGCGGCCCTTGACGTGGGGCAGCTTCTTGAGCTCCTCGTAGGTGA GCTCGTCGGGGTCGCTGAGACCGTGCTGCTCGAGCGCCCAGTCGGCGAGATGGGGGTTGGCGCGG AGGAAGGAAGTCCAGAGATCCACGGCCAGGGCGGTTTGCAGACGGTCCCGGTACTGACGGAACTG CTGCCCGACGGCCATTTTTTCGGGGGTGACGCAGTAGAAGGTGCGGGGGTCCCCGTGCCAGCGGT CCCATTTGAGCTGGAGGGCGAGATCGAGGGCGAGCTCGACGAGGCGGTCGTCCCCTGAGAGTTTC ATGACCAGCATGAAGGGGACGAGCTGCTTGCCGAAGGACCCCATCCAGGTGTAGGTTTCCACATC GTAGGTGAGGAAGAGCCTTTCGGTGCGAGGATGCGAGCCGATGGGGAAGAACTGGATCTCCTGCC ACCAATTGGAGGAATGGCTGTTGATGTGATGGAAGTAGAAATGCCGACGGCGCGCCGAACACTCG TGCTTGTGTTTATACAAGCGGCCACAGTGCTCGCAACGCTGCACGGGATGCACGTGCTGCACGAG CTGTACCTGAGTTCCTTTGACGAGGAATTTCAGTGGGAAGTGGAGTCGTGGCGCCTGCATCTCGT GCTGTACTACGTCGTGGTGGTCGGCCTGGCCCTCTTCTGCCTCGATGGTGGTCATGCTGACGAGC CCGCGCGGGAGGCAGGTCCAGACCTCGGCGCGAGCGGGTCGGAGAGCGAGGACGAGGGCGCGCAG GCCGGAGCTGTCCAGGGTCCTGAGACGCTGCGGAGTCAGGTCAGTGGGCAGCGGCGGCGCGCGGT TGACTTGCAGGAGTTTTTCCAGGGCGCGCGGGAGGTCCAGATGGTACTTGATCTCCACCGCGCCG TTGGTGGCGACGTCGATGGCTTGCAGGGTCCCGTGCCCCTGGGGTGTGACCACCGTCCCCCGTTT CTTCTTGGGCGGCTGGGGCGACGGGGGCGGTGCCTCTTCCATGGTTAGAAGCGGCGGCGAGGACG CGCGCCGGGCGGCAGAGGCGGCTCGGGGCCCGGAGGCAGGGGCGGCAGGGGCACGTCGGCGCCGC GCGCGGGTAGGTTCTGGTACTGCGCCCGGAGAAGACTGGCGTGAGCGACGACGCGACGGTTGACG TCCTGGATCTGACGCCTCTGGGTGAAGGCCACGGGACCCGTGAGTTTGAACCTGAAAGAGAGTTC GACAGAATCAATCTCGGTATCGTTGACGGCGGCCTGCCGCAGGATCTCTTGCACGTCGCCCGAGT TGTCCTGGTAGGCGATCTCGGTCATGAACTGCTCGATCTCCTCCTCCTGAAGGTCTCCGCGACCG GCGCGCTCCACGGTGGCCGCGAGGTCGTTGGAGATGCGGCCCATGAGCTGCGAGAAGGCGTTCAT GCCCGCCTCGTTCCAGACGCGGCTGTAGACCACGACGCCCTCGGGATCGCGGGCGCGCATGACCA CCTGGGCGAGGTTGAGCTCCACGTGGCGCGTGAAGACCGCGTAGTTGCAGAGGCGCTGGTAGAGG TAGTTGAGCGTGGTGGCGATGTGCTCGGTGACGAAGAAATACATGATCCAGCGGCGGAGCGGCAT CTCGCTGACGTCGCCCAGCGCCTCCAAGCGTTCCATGGCCTCGTAAAAGTCCACGGCGAAGTTGA AAAACTGGGAGTTGCGCGCCGAGACGGTCAACTCCTCCTCCAGAAGACGGATGAGCTCGGCGATG GTGGCGCGCACCTCGCGCTCGAAGGCCCCCGGGAGTTCCTCCACTTCCTCCTCTTCTTCCTCCTC CACTAACATCTCTTCTACTTCCTCCTCAGGCGGTGGTGGTGGCGGGGGAGGGGGCCTGCGTCGCC GGCGGCGCACGGGCAGACGGTCGATGAAGCGCTCGATGGTCTCGCCGCGCCGGCGTCGCATGGTC TCGGTGACGGCGCGCCCGTCCTCGCGGGGCCGCAGCGTGAAGACGCCGCCGCGCATCTCCAGGTG GCCGGGGGGGTCCCCGTTGGGCAGGGAGAGGGCGCTGACGATGCATCTTATCAATTGCCCCGTAG GGACTCCGCGCAAGGACCTGAGCGTCTCGAGATCCACGGGATCTGAAAACCGTTGAACGAAGGCT TCGAGCCAGTCGCAGTCGCAAGGTAGGCTGAGCACGGTTTCTTCTGCCGGGTCATGTTGGGGAGC GGGGCGGGCGATGCTGCTGGTGATGAAGTTGAAATAGGCGGTTCTGAGACGGCGGATGGTGGCGA GGAGCACCAGGTCTTTGGGCCCGGCTTGCTGGATGCGCAGACGGTCGGCCATGCCCCAGGCGTGG TCCTGACACCTGGCCAGGTCCTTGTAGTAGTCCTGCATGAGCCGCTCCACGGGCACCTCCTCCTC GCCCGCGCGGCCGTGCATGCGCGTGAGCCCGAAGCCGCGCTGGGGCTGGACGAGCGCCAGGTCGG CGACGACGCGCTCGGCGAGGATGGCCTGCTGGATCTGGGTGAGGGTGGTCTGGAAGTCGTCAAAG TCGACGAAGCGGTGGTAGGCTCCGGTGTTGATGGTGTAGGAGCAGTTGGCCATGACGGACCAGTT GACGGTCTGGTGGCCCGGACGCACGAGCTCGTGGTACTTGAGGCGCGAGTAGGCGCGCGTGTCGA AGATGTAGTCGTTGCAGGTGCGCACCAGGTACTGGTAGCCGATGAGGAAGTGCGGCGGCGGCTGG CGGTAGAGCGGCCATCGCTCGGTGGCGGGGGCGCCGGGCGCGAGGTCCTCGAGCATGGTGCGGTG GTAGCCGTAGATGTACCTGGACATCCAGGTGATGCCGGCGGCGGTGGTGGAGGCGCGCGGGAACT CGCGGACGCGGTTCCAGATGTTGCGCAGCGGCAGGAAGTAGTTCATGGTGGGCACGGTCTGGCCC GTGAGGCGCGCGCAGTCGTGGATGCTCTATACGGGCAAAAACGAAAGCGGTCAGCGGCTCGACTC CGTGGCCTGGAGGCTAAGCGAACGGGTTGGGCTGCGCGTGTACCCCGGTTCGAATCTCGAATCAG GCTGGAGCCGCAGCTAACGTGGTACTGGCACTCCCGTCTCGACCCAAGCCTGCACCAACCCTCCA GGATACGGAGGCGGGTCGTTTTGCAACTTTTTTtGGAGGCCGGAAATGAAACTAGTAAGCGCGGA AAGCGGCCGACCGCGATGGCTCGCTGCCGTAGTCTGGAGAAGAATCGCCAGGGTTGCGTTGCGGT GTGCCCCGGTTCGAGGCCGGCCGGATTCCGCGGCTAACGAGGGCGTGGCTGCCCCGTCGTTTCCA AGACCCCATAGCCAGCCGACTTCTCCAGTTACGGAGCGAGCCCCTCTTTTGTTTTGTTTGTTTTT GCCAGATGCATCCCGTACTGCGGCAGATGCGCCCCCACCACCCTCCACCGCAACAACAGCCCCCT CCTCCACAGCCGGCGCTTCTGCCCCCGCCCCAGCAGCAGCAGCAACTTCCAGCCACGACCGCCGC GGCCGCCGTGAGCGGGGCTGGACAGACTTCTCAGTATGATCACCTGGCCTTGGAAGAGGGCGAGG GGCTGGCGCGCCTGGGGGCGTCGTCGCCGGAGCGGCACCCGCGCGTGCAGATGAAAAGGGACGCT CGCGAGGCCTACGTGCCCAAGCAGAACCTGTTCAGAGACAGGAGCGGCGAGGAGCCCGAGGAGAT GCGCGCGGCCCGGTTCCACGCGGGGCGGGAGCTGCGGCGCGGCCTGGACCGAAAGAGGGTGCTGA GGGACGAGGATTTCGAGGCGGACGAGCTGACGGGGATCAGCCCCGCGCGCGCGCACGTGGCCGCG GCCAACCTGGTCACGGCGTACGAGCAGACCGTGAAGGAGGAGAGCAACTTCCAAAAATCCTTCAA CAACCACGTGCGCACCCTGATCGCGCGCGAGGAGGTGACCCTGGGCCTGATGCACCTGTGGGACC TGCTGGAGGCCATCGTGCAGAACCCCACCAGCAAGCCGCTGACGGCGCAGCTGTTCCTGGTGGTG CAGCATAGTCGGGACAACGAGGCGTTCAGGGAGGCGCTGCTGAATATCACCGAGCCCGAGGGCCG CTGGCTCCTGGACCTGGTGAACATTCTGCAGAGCATCGTGGTGCAGGAGCGCGGGCTGCCGCTGT CCGAGAAGCTGGCGGCCATCAACTTCTCGGTGCTGAGTCTGGGCAAGTACTACGCTAGGAAGATC TACAAGACCCCGTACGTGCCCATAGACAAGGAGGTGAAGATCGACGGGTTTTACATGCGCATGAC CCTGAAAGTGCTGACCCTGAGCGACGATCTGGGGGTGTACCGCAACGACAGGATGCACCGCGCGG TGAGCGCCAGCAGGCGGCGCGAGCTGAGCGACCAGGAGCTGATGCACAGCCTGCAGCGGGCCCTG ACCGGGGCCGGGACCGAGGGGGAGAGCTACTTTGACATGGGCGCGGACCTGCACTGGCAGCCCAG CCGCCGGGCCTTGGAGGCGGCAGGCGGTCCCCCCTACATAGAAGAGGTGGACGATGAGGTGGACG AGGAGGGCGAGTACCTGGAAGACTGATGGCGCGACCGTATTTTTGCTAGATGCAACAACAGCCAC CTCCTGATCCCGCGATGCGGGCGGCGCTGCAGAGCCAGCCGTCCGGCATTAACTCCTCGGACGAT TGGACCCAGGCCATGCAACGCATCATGGCGCTGACGACCCGCAACCCCGAAGCCTTTAGACAGCA GCCCCAGGCCAACCGGCTCTCGGCCATCCTGGAGGCCGTGGTGCCCTCGCGCTCCAACCCCACGC ACGAGAAGGTCCTGGCCATCGTGAACGCGCTGGTGGAGAACAAGGCCATCCGCGGCGACGAGGCC GGCCTGGTGTACAACGCGCTGCTGGAGCGCGTGGCCCGCTACAACAGCACCAACGTGCAGACCAA CCTGGACCGCATGGTGACCGACGTGCGCGAGGCCGTGGCCCAGCGCGAGCGGTTCCACCGCGAGT CCAACCTGGGATCCATGGTGGCGCTGAACGCCTTCCTCAGCACCCAGCCCGCCAACGTGCCCCGG GGCCAGGAGGACTACACCAACTTCATCAGCGCCCTGCGCCTGATGGTGACCGAGGTGCCCCAGAG CGAGGTGTACCAGTCCGGGCCGGACTACTTCTTCCAGACCAGTCGCCAGGGCTTGCAGACCGTGA ACCTGAGCCAGGCGTTCAAGAACTTGCAGGGCCTGTGGGGCGTGCAGGCCCCGGTCGGGGACCGC GCGACGGTGTCGAGCCTGCTGACGCCGAACTCGCGCCTGCTGCTGCTGCTGGTGGCCCCCTTCAC GGACAGCGGCAGCATCAACCGCAACTCGTACCTGGGCTACCTGATTAACCTGTACCGCGAGGCCA TCGGCCAGGCGCACGTGGACGAGCAGACCTACCAGGAGATCACCCACGTGAGCCGCGCCCTGGGC CAGGACGACCCGGGCAATCTGGAAGCCACCCTGAACTTTTTGCTGACCAACCGGTCGCAGAAGAT CCCGCCCCAGTACACGCTCAGCGCCGAGGAGGAGCGCATCCTGCGATACGTGCAGCAGAGCGTGG GCCTGTTCCTGATGCAGGAGGGGGCCACCCCCAGCGCCGCGCTCGACATGACCGCGCGCAACATG GAGCCCAGCATGTACGCCAGCAACCGCCCGTTCATCAATAAACTGATGGACTACTTGCATCGGGC GGCCGCCATGAACTCTGACTATTTCACCAACGCCATCCTGAATCCCCACTGGCTCCCGCCGCCGG GGTTCTACACGGGCGAGTACGACATGCCCGACCCCAATGACGGGTTCCTGTGGGACGATGTGGAC AGCAGCGTGTTCTCCCCCCGACCGGGTGCTAACGAGCGCCCCTTGTGGAAGAAGGAAGGCAGCGA CCGACGCCCGTCCTCGGCGCTGTCCGGCCGCGAGGGTGCTGCCGCGGCGGTGCCCGAGGCCGCCA GTCCTTTCCCGAGCTTGCCCTTCTCGCTGAACAGTATTCGCAGCAGCGAGCTGGGCAGGATCACG CGCCCGCGCTTGCTGGGCGAGGAGGAGTACTTGAATGACTCGCTGTTGAGACCCGAGCGGGAGAA GAACTTCCCCAATAACGGGATAGAGAGCCTGGTGGACAAGATGAGCCGCTGGAAGACGTATGCGC AGGAGCACAGGGACGATCCGTCGCAGGGGGCCACGAGCCGGGGCAGCGCCGCCCGTAAACGCCGG TGGCACGACAGGCAGCGGGGACTGATGTGGGACGATGAGGATTCCGCCGACGACAGCAGCGTGTT GGACTTGGGTGGGAGTGGTAACCCGTTCGCTCACCTGCGCCCCCGCATCGGGCGCATGATGTAAG AGAAACCGAAAATAAATGATACTCACCAAGGCCATGGCGACCAGCGTGCGTTCGTTTCTTCTCTG TTGTTGTATCTAGTATGATGAGGCGTGCGTACCCGGAGGGTCCTCCTCCCTCGTACGAGAGCGTG ATGCAGCAGGCGATGGCGGCGGCGGCGGCGATGCAGCCCCCGCTGGAGGCTCCTTACGTGCCCCC GCGGTACCTGGCGCCTACGGAGGGGCGGAACAGCATTCGTTACTCGGAGCTGGCACCCTTGTACG ATACCACCCGGTTGTACCTGGTGGACAACAAGTCGGCGGACATCGCCTCGCTGAACTACCAGAAC GACCACAGCAACTTCCTGACCACCGTGGTGCAGAACAATGACTTCACCCCCACGGAGGCCAGCAC CCAGACCATCAACTTTGACGAGCGCTCGCGGTGGGGCGGTCAGCTGAAAACCATCATGCACACCA ACATGCCCAACGTGAACGAGTTCATGTACAGCAACAAGTTCAAGGCGCGGGTGATGGTCTCCCGC AAGACCCCCAACGGGGTGACAGTGACAGATGGTAGTCAGGATATCTTGGAGTATGAATGGGTGGA GTTTGAGCTGCCCGAAGGCAACTTCTCGGTGACCATGACCATCGACCTGATGAACAACGCCATCA TCGACAATTACTTGGCGGTGGGGCGGCAGAACGGGGTCCTGGAGAGCGATATCGGCGTGAAGTTC GACACTAGGAACTTCAGGCTGGGCTGGGACCCCGTGACCGAGCTGGTCATGCCCGGGGTGTACAC CAACGAGGCCTTCCACCCCGATATTGTCTTGCTGCCCGGCTGCGGGGTGGACTTCACCGAGAGCC GCCTCAGCAACCTGCTGGGCATTCGCAAGAGGCAGCCCTTCCAGGAGGGCTTCCAGATCATGTAC GAGGATCTGGAGGGGGGCAACATCCCCGCGCTCCTGGATGTCGACGCCTATGAGAAAAGCAAGGA GGAGAGCGCCGCCGCGGCGACTGCAGCTGTAGCCACCGCCTCTACCGAGGTCAGGGGCGATAATT TTGCCAGCCCTGCAGCAGTGGCAGCGGCCGAGGCGGCTGAAACCGAAAGTAAGATAGTCATTCAG CCGGTGGAGAAGGATAGCAAGGACAGGAGCTACAACGTGCTGCCGGACAAGATAAACACCGCCTA CCGCAGCTGGTACCTGGCCTACAACTATGGCGACCCCGAGAAGGGCGTGCGCTCCTGGACGCTGC TCACCACCTCGGACGTCACCTGCGGCGTGGAGCAAGTCTACTGGTCGCTGCCCGACATGATGCAA GACCCGGTCACCTTCCGCTCCACGCGTCAAGTTAGCAACTACCCGGTGGTGGGCGCCGAGCTCCT GCCCGTCTACTCCAAGAGCTTCTTCAACGAGCAGGCCGTCTACTCGCAGCAGCTGCGCGCCTTCA CCTCGCTCACGCACGTCTTCAACCGCTTCCCCGAGAACCAGATCCTCGTCCGCCCGCCCGCGCCC ACCATTACCACCGTCAGTGAAAACGTTCCTGCTCTCACAGATCACGGGACCCTGCCGCTGCGCAG CAGTATCCGGGGAGTCCAGCGCGTGACCGTTACTGACGCCAGACGCCGCACCTGCCCCTACGTCT ACAAGGCCCTGGGCATAGTCGCGCCGCGCGTCCTCTCGAGCCGCACCTTCTAAAAAATGTCCATT CTCATCTCGCCCAGTAATAACACCGGTTGGGGCCTGCGCGCGCCCAGCAAGATGTACGGAGGCGC TCGCCAACGCTCCACGCAACACCCCGTGCGCGTGCGCGGGCACTTCCGCGCTCCCTGGGGCGCCC TCAAGGGCCGCGTGCGGTCGCGCACCACCGTCGACGACGTGATCGACCAGGTGGTGGCCGACGCG CGCAACTACACCCCCGCCGCCGCGCCCGTCTCCACCGTGGACGCCGTCATCGACAGCGTGGTGGC CGACGCGCGCCGGTACGCCCGCGCCAAGAGCCGGCGGCGGCGCATCGCCCGGCGGCACCGGAGCA CCCCCGCCATGCGCGCGGCGCGAGCCTTGCTGCGCAGGGCCAGGCGCACGGGACGCAGGGCCATG CTCAGGGCGGCCAGACGCGCGGCTTCAGGCGCCAGCGCCGGCAGGACCCGGAGACGCGCGGCCAC GGCGGCGGCAGCGGCCATCGCCAGCATGTCCCGCCCGCGGCGAGGGAACGTGTACTGGGTGCGCG ACGCCGCCACCGGTGTGCGCGTGCCCGTGCGCACCCGcCCCCCTCGCACTTGAAGATGTTCACTT CGCGATGTTGATGTGTCCCAGCGGCGAGGAGGATGTCCAAGCGCAAATTCAAGGAAGAGATGCTC CAGGTCATCGCGCCTGAGATCTACGGCCCCGCGGTGGTGAAGGAGGAAAGAAAGCCCCGCAAAAT CAAGCGGGTCAAAAAGGACAAAAAGGAAGAAGATGACGATCTGGTGGAGTTTGTGCGCGAGTTCG CCCCCcGGCGGCGCGTGCAGTGGCGCGGGCGGAAAGTGCACCCGGTGCTGAGACCCGGCACCACC GTGGTCTTCACGCCCGGCGAGCGCTCCGGCAGCGCTTCCAAGCGCTCCTACGACGAGGTGTACGG GGACGAGGACATCCTCGAGCAGGCGGCCGAGCGCCTGGGCGAGTTTGCTTACGGCAAGCGCAGCC GCCCCGCCCTGAAGGAAGAGGCGGTGTCCATCCCGCTGGACCACGGCAACCCCACGCCGAGCCTC AAGCCCGTGACCCTGCAGCAGGTGCTGCCGAGCGCAGCGCCGCGCCGGGGGTTCAAGCGCGAGGG CGAGGATCTGTACCCCACCATGCAGCTGATGGTGCCCAAGCGCCAGAAGCTGGAAGACGTGCTGG AGACCATGAAGGTGGACCCGGACGTGCAGCCCGAGGTCAAGGTGCGGCCCATCAAGCAGGTGGCC CCGGGCCTGGGCGTGCAGACCGTGGACATCAAGATCCCCACGGAGCCCATGGAAACGCAGACCGA GCCCATGATCAAGCCCAGCACCAGCACCATGGAGGTGCAGACGGATCCCTGGATGCCATCGGCTC CTAGCCGAAGACCCCGGCGCAAGTACGGCGCGGCCAGCCTGCTGATGCCCAACTACGCGCTGCAT CCTTCCATCATCCCCACGCCGGGCTACCGCGGCACGCGCTTCTACCGCGGTCATACAACCAGCCG CCGCCGCAAGACCACCACCCGCCGCCGCCGTCGCCGCACAGCCGCTGCATCTACCCCTGCCGCCC TGGTGCGGAGAGTGTACCGCCGCGGCCGCGCGCCTCTGACCCTACCGCGCGCGCGCTACCACCCG AGCATCGCCATTTAAACTTTCGCCTGCTTTGCAGATGGCCCTCACATGCCGCCTCCGCGTTCCCA TTACGGGCTACCGAGGAAGAAAACCGCGCCGTAGAAGGCTGGCGGGGAACGGGATGCGTCGCCAC CACCATCGGCGGCGGCGCGCCATCAGCAAGCGGTTGGGGGgAGGCTTCCTGCCCGCGCTGATCCC CATCATCGCCGCGGCGATCGGGGCGATCCCCGGCATTGCTTCCGTGGCGGTGCAGGCCTCTCAGC GCCACTGAGACACTTGGAAAACATCTTGTAATAAACCAATGGACTCTGACGCTCCTGGTCCTGTG ATGTGTTTTCGTAGACAGATGGAAGACATCAATTTTTCGTCCCTGGCTCCGCGACACGGCACGCG GCCGTTCATGGGCACCTGGAGCGACATCGGCACCAGCCAACTGAACGGGGGCGCCTTCAATTGGA GCAGTCTCTGGAGCGGGCTTAAGAATTTCGGGTCCACGCTTAAAACCTATGGCAGCAAGGCGTGG AACAGCACCACAGGGCAGGCGCTGAGGGATAAGCTGAAAGAGCAGAACTTCCAGCAGAAGGTGGT CGATGGGCTCGCCTCGGGCATCAACGGGGTGGTGGACCTGGCCAACCAGGCCGTGCAGCGGCAGA TCAACAGCCGCCTGGACCCGGTGCCGCCCGCCGGCTCCGTGGAGATGCCGCAGGTGGAGGAGGAG CTGCCTCCCCTGGACAAGCGGGGCGAGAAGCGACCCCGCCCCGACGCGGAGGAGACGCTGCTGAC GCACACGGACGAGCCGCCCCCGTACGAGGAGGCGGTGAAACTGGGTCTGCCCACCACGCGGCCCA TCGCGCCCCTGGCCACCGGGGTGCTGAAACCCGAAAGTAATAAGCCCGCGACCCTGGACTTGCCT CCTCCCGCTTCCCGCCCCTCTACAGTGGCTAAGCCCCTGCCGCCGGTGGCCGTGGCCCGCGCGCG ACCCGGGGGCTCCGCCCGCCCTCATGCGAACTGGCAGAGCACTCTGAACAGCATCGTGGGTCTGG GAGTGCAGAGTGTGAAGCGCCGCCGCTGCTATTAAACCTACCGTAGCGCTTAACTTGCTTGTCTG TGTGTGTATGTATTATGTCGCCGCTGTCCGCCAGAAGGAGGAGTGAAGAGGCGCGTCGCCGAGTT GCAAGATGGCCACCCCATCGATGCTGCCCCAGTGGGCGTACATGCACATCGCCGGACAGGACGCT TCGGAGTACCTGAGTCCGGGTCTGGTGCAGTTCGCCCGCGCCACAGACACCTACTTCAGTCTGGG GAACAAGTTTAGGAACCCCACGGTGGCGCCCACGCACGATGTGACCACCGACCGCAGCCAGCGGC TGACGCTGCGCTTCGTGCCCGTGGACCGCGAGGACAACACCTACTCGTACAAAGTGCGCTACACG CTGGCCGTGGGCGACAACCGCGTGCTGGACATGGCCAGCACCTACTTTGACATCCGCGGCGTGCT GGATCGGGGCCCTAGCTTCAAACCCTACTCCGGCACCGCCTACAACAGCCTGGCTCCCAAGGGAG CGCCCAATTCCAGCCAGTGGGAGCaAAAAAAGGCAGGCAATGGTGACACTATGGAAACACACACA TTTGGTGTGGCCCCAATGGGCGGTGAGAATATTACAATCGACGGATTACAAATTGGAACTGACGC TACAGCTGATCAGGATAAACCAATTTATGCTGACAAAACATTCCAGCCTGAACCTCAAGTAGGAG AAGAAAATTGGCAAGAAACTGAAAGCTTTTATGGCGGTAGGGCTCTTAAAAAAGACACAAGCATG AAACCTTGCTATGGCTCCTATGCTAGACCCACCAATGTAAAGGGAGGTCAAGCTAAACTTAAAGT TGGAGCTGATGGAGTTCCTACCAAAGAATTTGACATAGACCTGGCTTTCTTTGATACTCCCGGTG GCACAGTGAATGGACAAGATGAGTATAAAGCAGACATTGTCATGTATACCGAAAACACGTATCTG GAAACTCCAGACACGCATGTGGTATACAAACCAGGCAAGGATGATGCAAGTTCTGAAATTAACCT GGTTCAGCAGTCCATGCCCAATAGACCCAACTATATTGGGTTCAGAGACAACTTTATTGGGCTCA TGTATTACAACAGTACTGGCAATATGGGGGTGCTGGCTGGTCAGGCCTCACAGCTGAATGCTGTG GTCGACTTGCAAGACAGAAACACCGAGCTGTCATACCAGCTCTTGCTTGACTCTTTGGGTGACAG AACCCGGTATTTCAGTATGTGGAATCAGGCGGTGGACAGTTATGATCCTGATGTGCGCATTATTG AAAACCATGGTGTGGAAGACGAACTTCCCAACTATTGCTTCCCCCTGGATGGGTCTGGCACTAAT GCCGCTTACCAAGGTGTGAAAGTAAAAAATGGTAACGATGGTGATGTTGAGAGCGAATGGGAAAA TGATGATACTGTCGCAGCTCGAAATCAATTATGCAAGGGCAACATTTTTGCCATGGAAATTAACC TCCAAGCCAACCTGTGGAGAAGTTTCCTCTACTCGAACGTGGCCCTGTACCTGCCCGACTCTTAC AAGTACACGCCAGCCAACATCACCCTGCCCACCAACACCAACACTTATGATTACATGAACGGGAG AGTGGTGCCTCCCTCGCTGGTGGACGCCTACATCAACATCGGGGCGCGCTGGTCGCTGGACCCCA TGGACAACGTCAATCCCTTCAACCACCACCGCAACGCGGGCCTGCGCTACCGCTCCATGCTCCTG GGCAACGGGCGCTACGTGCCCTTCCACATCCAGGTGCCCCAGAAATTTTTCGCCATCAAGAGCCT CCTGCTCCTGCCCGGGTCCTACACCTACGAGTGGAACTTCCGCAAGGACGTCAACATGATCCTGC AGAGCTCCCTCGGCAACGACCTGCGCACGGACGGGGCCTCCATCTCCTTCACCAGCATCAACCTC TACGCCACCTTCTTCCCCATGGCGCACAACACGGCCTCCACGCTCGAGGCCATGCTGCGCAACGA CACCAACGACCAGTCCTTCAACGACTACCTCTCGGCGGCCAACATGCTCTACCCCATCCCGGCCA ACGCCACCAACGTGCCCATCTCCATCCCCTCGCGCAACTGGGCCGCCTTCCGCGGCTGGTCCTTC ACGCGCCTCAAGACCAAGGAGACGCCCTCGCTGGGCTCCGGGTTCGACCCCTACTTCGTCTACTC GGGCTCCATCCCCTACCTCGACGGCACCTTCTACCTCAACCACACCTTCAAGAAGGTCTCCATCA CCTTCGACTCCTCCGTCAGCTGGCCCGGCAACGACCGGCTCCTGACGCCCAACGAGTTCGAAATC AAGCGCACCGTCGACGGCGAGGGATACAACGTGGCCCAGTGCAACATGACCAAGGACTGGTTCCT GGTCCAGATGCTGGCCCACTACAACATCGGCTACCAGGGCTTCTACGTGCCCGAGGGCTACAAGG ACCGCATGTACTCCTTCTTCCGCAACTTCCAGCCCATGAGCCGCCAGGTGGTGGACGAGGTCAAC TACAAGGACTACCAGGCCGTCACCCTGGCCTACCAGCACAACAACTCGGGCTTCGTCGGCTACCT CGCGCCCACCATGCGCCAGGGCCAGCCCTACCCCGCCAACTACCCGTACCCGCTCATCGGCAAGA GCGCCGTCACCAGCGTCACCCAGAAAAAGTTCCTCTGCGACAGGGTCATGTGGCGCATCCCCTTC TCCAGCAACTTCATGTCCATGGGCGCGCTCACCGACCTCGGCCAGAACATGCTCTATGCCAACTC CGCCCACGCGCTAGACATGAATTTCGAAGTCGACCCCATGGATGAGTCCACCCTTCTCTATGTTG TCTTCGAAGTCTTCGACGTCGTCCGAGTGCACCAGCCCCACCGCGGCGTCATCGAGGCCGTCTAC CTGCGCACCCCCTTCTCGGCCGGTAACGCCACCACCTAAATTGCTACTTGCATGATGGCTGAGCC CACAGGCTCCGGCGAGCAGGAGCTCAGGGCCATCATCCGCGACCTGGGCTGCGGGCCCTACTTCC TGGGCACCTTCGATAAGCGCTTCCCGGGATTCATGGCCCCGCACAAGCTGGCCTGCGCCATCGTC AACACGGCCGGCCGCGAGACCGGGGGCGAGCACTGGCTGGCCTTCGCCTGGAACCCGCGCTCGAA CACCTGCTACCTCTTCGACCCCTTCGGGTTCTCGGACGAGCGCCTCAAGCAGATCTACCAGTTCG AGTACGAGGGCCTGCTGCGCCGTAGCGCCCTGGCCACCGAGGACCGCTGCGTCACCCTGGAAAAG TCCACCCAGACCGTGCAGGGTCCGCGCTCGGCCGCCTGCGGGCTCTTCTGCTGCATGTTCCTGCA CGCCTTCGTGCACTGGCCCGACCGCCCCATGGACAAGAACCCCACCATGAACTTGCTGACGGGGG TGCCCAACGGCATGCTCCAGTCGCCCCAGGTGGAACCCACCCTGCGCCGCAACCAGGAGGCGCTC TACCGCTTCCTCAACTCCCACTCCGCCTACTTTCGCTCCCACCGCGCGCGCATCGAGAAGGCCAC CGCCTTCGACCGCATGAACAATCAAGACATGTAAACCGTGTGTGTATGTTTAAAATATCTTTTAA TAAACAGCACTTTAATGTTACACATGCATCTGAGATGATTTTATTTTAGAAATCGAAAGGGTTCT GCCGGGTCTCGGCATGGCCCGCGGGCAGGGACACGTTGCGGAACTGGTACTTGGCCAGCCACTTG AACTCGGGGATCAGCAGTTTGGGCAGCGGGGTGTCGGGGAAGGAGTCGGTCCACAGCTTCCGCGT CAGCTGCAGGGCGCCCAGCAGGTCGGGCGCGGAGATCTTGAAATCGCAGTTGGGACCCGCGTTCT GCGCGCGAGAGTTGCGGTACACGGGGTTGCAGCACTGGAACACCATCAGGGCCGGGTGCTTCACG CTCGCCAGCACCGCCGCGTCGGTGATGCTCTCCACGTCGAGGTCCTCGGCGTTGGCCATCCCGAA GGGGGTCATCTTGCAGGTCTGCCTTCCCATGGTGGGCACGCACCCGGGCTTGTGGTTGCAATCGC AGTGCAGGGGGATCAGCATCATCTGGGCCTGGTCGGCGTTCATCCCCGGGTACATGGCCTTCATG AAAGCCTCCAATTGCCTGAACGCCTGCTGGGCCTTGGCTCCCTCGGTGAAGAAGACCCCGCAGGA CTTGCTAGAGAACTGGTTGGTGGCACAGCCGGCATCGTGCACGCAGCAGCGCGCGTCGTTGTTGG CCAGCTGCACCACGCTGCGCCCCCAGCGGTTCTGGGTGATCTTGGCCCGGTCGGGGTTCTCCTTC AGCGCGCGCTGCCCGTTCTCGCTCGCCACATCCATCTCGATCATGTGCTCCTTCTGGATCATGGT GGTCCCGTGCAGGCACCGCAGTTTGCCCTCGGCCTCGGTGCACCCGTGCAGCCACAGCGCGCACC CGGTGCACTCCCAGTTCTTGTGGGCGATCTGGGAATGCGCGTGCACGAACCCTTGCAGGAAGCGG CCCATCATGGTCGTCAGGGTCTTGTTGCTAGTGAAGGTCAACGGGATGCCGCGGTGCTCCTCGTT GATGTACAGGTGGCAGATGCGGCGGTACACCTCGCCCTGCTCGGGCATCAGTTGGAAGTTGGCTT TCAGGTCGGTCTCCACGCGGTAGCGGTCCATCAGCATAGTCATGATTTCCATGCCCTTCTCCCAG GCCGAGACGATGGGCAGGCTCATAGGGTTCTTCACCATCATCTTAGCACTAGCAGCCGCGGCCAG GGGGTCGCTCTCATCCAGGGTCTCAAAGCTCCGCTTGCCGTCCTTCTCGGTGATCCGCACCGGGG GGTAGCTGAAGCCCACGGCCGCCAGCTCCTCCTCGGCCTGTCTTTCGTCCTCGCTGTCCTGGCTG ACGTCCTGCATGACCACATGCTTGGTCTTGCGGGGTTTCTTCTTGGGCGGCAGTGGCGGCGGAGA TGCTTGTGGCGAGGGGGAGCGCGAGTTCTCGCTCACCACTACTATCTCTTCCTCTTCTTGGTCCG AGGCCACGCGGCGGTAGGTATGTCTCTTCGGGGGCAGAGGCGGAGGCGACGGGCTCTCGCCGCCG CGACTTGGCGGATGGCTGGCAGAGCCCCTTCCGCGTTCGGGGGTGCGCTCCCGGCGGCGCTCTGA CTGACTTCCTCCGCGGCCGGCCATTGTGTTCTCCTAGGGAGGAACAACAAGCATGGAGACTCAGC CATCGCCAACCTCGCCATCTGCCCCCACCGCCGGCGACGAGAAGCAGCAGCAGCAGAATGAAAGC TTAACCGCCCCGCCGCCCAGCCCCGCCTCCGACGCAGCCGCGGTCCCAGACATGCAAGAGATGGA GGAATCCATCGAGATTGACCTGGGCTATGTGACGCCCGCGGAGCATGAGGAGGAGCTGGCAGTGC GCTTTCAATCGTCAAGCCAGGAAGATAAAGAACAGCCAGAGCAGGAAGCAGAGAACGAGCAGAGT CAGGCTGGGCTCGAGCATGGCGACTACCTCCACCTGAGCGGGGAGGAGGACGCGCTCATCAAGCA TCTGGCCCGGCAGGCCACCATCGTCAAGGACGCGCTGCTCGACCGCACCGAGGTGCCCCTCAGCG TGGAGGAGCTCAGCCGCGCCTACGAGCTCAACCTCTTCTCGCCGCGCGTGcCCCCCAAGCGCCAG CCCAACGGCACCTGCGAGCCCAACCCCCGCCTCAACTTCTACCCGGTCTTCGCGGTGCCCGAGGC CCTGGCCACCTACCACATCTTTTtCAAGAACCAAAAGATCCCCGTCTCCTGCCGCGCCAACCGCA CCCGCGCCGACGCCCTCTTCAACCTGGGTCCCGGCGCCCGCCTACCTGATATCGCCTCCTTGGAA GAGGTTCCCAAGATCTTCGAGGGTCTGGGCAGCGACGAGACTCGGGCCGCGAACGCTCTGCAAGG AGAAGGAGGAGGAGAGCATGAGCACCACAGCGCCCTGGTCGAGTTGGAAGGCGACAACGCGCGGC TGGCGGTGCTCAAACGCACGGTCGAGCTGACCCATTTCGCCTACCCGGCTCTGAACCTGcCCCCG AAAGTCATGAGCGCGGTCATGGACCAGGTGCTCATCAAGCGCGCGTCGCCCATCTCCGAGGACGA GGGCATGCAAGACTCCGAGGAGGGCAAGCCCGTGGTCAGCGACGAGCAGCTGGCCCGGTGGCTGG GTCCTAATGCTACCCCTCAAAGTTTGGAAGAGCGGCGCAAGCTCATGATGGCCGTGGTCCTGGTG ACCGTGGAGCTGGAGTGCCTGCGCCGCTTCTTCGCCGACGCGGAGACCCTGCGCAAGGTCGAGGA GAACCTGCACTACCTCTTCAGGCACGGGTTCGTGCGCCAGGCCTGCAAGATCTCCAACGTGGAGC TGACCAACCTGGTCTCCTACATGGGCATCTTGCACGAGAACCGCCTGGGGCAGAACGTGCTGCAC ACCACCCTGCGCGGGGAGGCCCGCCGCGACTACATCCGCGACTGCGTCTACCTCTACCTCTGCCA CACCTGGCAGACGGGCATGGGCGTGTGGCAGCAGTGTCTGGAGGAGCAGAACCTGAAAGAGCTCT GCAAGCTCCTGCAAAAGAACCTCAAGGGTCTGTGGACCGGGTTCGACGAGCGGACCACCGCCTCG GACCTGGCCGACCTCATCTTCCCCGAGCGCCTCAGGCTGACGCTGCGCAACGGCCTGCCCGACTT TATGAGCCAAAGCATGTTGCAAAACTTTCGCTCTTTCATCCTCGAACGCTCCGGAATCCTGCCCG CCACCTGCTCCGCGCTGCCCTCGGACTTCGTGCCGCTGACCTTCCGCGAGTGCCCCCCGCCGCTG TGGAGCCACTGCTACCTGCTGCGCCTGGCCAACTACCTGGCCTACCACTCGGACGTGATCGAGGA CGTCAGCGGCGAGGGCCTGCTCGAGTGCCACTGCCGCTGCAACCTCTGCACGCCGCACCGCTCCC TGGCCTGCAACCCCCAGCTGCTGAGCGAGACCCAGATCATCGGCACCTTCGAGTTGCAAGGGCCC AGCGAGGGCGAGGGAGCCAAGGGGGGTCTGAAACTCACCCCGGGGCTGTGGACCTCGGCCTACTT GCGCAAGTTCGTGCCCGAGGATTACCATCCCTTCGAGATCAGGTTCTACGAGGACCAATCCCAGC CGCCCAAGGCCGAGCTGTCGGCCTGCGTCATCACCCAGGGGGCGATCCTGGCCCAATTGCAAGCC ATCCAGAAATCCCGCCAAGAATTCTTGCTGAAAAAGGGCCGCGGGGTCTACCTCGACCCCCAGAC CGGTGAGGAGCTCAACCCCGGCTTCCCCCAGGATGCCCCGAGGAAACAAGAAGCTGAAAGTGGAG CTGCCGCCCGTGGAGGATTTGGAGGAAGACTGGGAGAACAGCAGTCAGGCAGAGGAGATGGAGGA AGACTGGGACAGCACTCAGGCAGAGGAGGACAGCCTGCAAGACAGTCTGGAGGAAGACGAGGAGG AGGCAGAGGAGGAGGTGGAAGAAGCAGCCGCCGCCAGACCGTCGTCCTCGGCGGGGGAGAAAGCA AGCAGCACGGATACCATCTCCGCTCCGGGTCGGGGTCCCGCTCGGCCCCACAGTAGATGGGACGA GACCGGGCGATTCCCGAACCCCACCACCCAGACCGGTAAGAAGGAGCGGCAGGGATACAAGTCCT GGCGGGGGCACAAAAACGCCATCGTCTCCTGCTTGCAGGCCTGCGGGGGCAACATCTCCTTCACC CGGCGCTACCTGCTCTTCCACCGCGGGGTGAACTTCCCCCGCAACATCTTGCATTACTACCGTCA CCTCCACAGCCCCTACTACTTCCAAGAAGAGGCAGCAGCAGCAGaAAAAGACCAGAAAACCAGCT AGAAAATCCACAGCGGCGGCAGCGGCAGGTGGACTGAGGATCGCGGCGAACGAGCCGGCGCAGAC CCGGGAGCTGAGGAACCGGATCTTTCCCACCCTCTATGCCATCTTCCAGCAGAGTCGGGGGCAGG AGCAGGAACTGAAAGTCAAGAACCGTTCTCTGCGCTCGCTCACCCGCAGTTGTCTGTATCACAAG AGCGAAGACCAACTTCAGCGCACTCTCGAGGACGCCGAGGCTCTCTTCAACAAGTACTGCGCGCT CACTCTTAAAGAGTAGCCCGCGCCCGCCCAGTCGCAGAAAAAGGCGGGAATTACGTCACCTGTGC CCTTCGCCCTAGCCGCCTCCACCCAGCACCGCCATGAGCAAAGAGATTCCCACGCCTTACATGTG GAGCTACCAGCCCCAGATGGGCCTGGCCGCCGGCGCCGCCCAGGACTACTCCACCCGCATGAATT GGCTCAGCGCCGGGCCCGCGATGATCTCACGGGTGAATGACATCCGCGCCCACCGAAACCAGATA CTCCTAGAACAGTCAGCGCTCACCGCCACGCCCCGCAATCACCTCAATCCGCGTAATTGGCCCGC CGCCCTGGTGTACCAGGAAATTCCCCAGCCCACGACCGTACTACTTCCGCGAGACGCCCAGGCCG AAGTCCAGCTGACTAACTCAGGTGTCCAGCTGGCGGGCGGCGCCACCCTGTGTCGTCACCGCCCC GCTCAGGGTATAAAGCGGCTGGTGATCCGGGGCAGAGGCACACAGCTCAACGACGAGGTGGTGAG CTCTTCGCTGGGTCTGCGACCTGACGGAGTCTTCCAACTCGCCGGATCGGGGAGATCTTCCTTCA CGCCTCGTCAGGCGGTCCTGACTTTGGAGAGTTCGTCCTCGCAGCCCCGCTCGGGCGGCATCGGC ACTCTCCAGTTCGTGGAGGAGTTCACTCCCTCGGTCTACTTCAACCCCTTCTCCGGCTCCCCCGG CCACTACCCGGACGAGTTCATCCCGAACTTTGACGCCATCAGCGAGTCGGTGGACGGCTACGATT GATTAATTAATCAACTAACCCCTTACCCCTTTACCCTCCAGTAAAAATAAAGATTAAAAATGATT GAATTGATCAATAAAGAATCACTTACTTGAAATCTGAAACCAGGTCTCTGTCCATGTTTTCTGTC AGCAGCACTTCACTCCCCTCTTCCCAACTCTGGTACTGCAGGCCCCGGCGGGCTGCAAACTTCCT CCACACTCTGAAGGGGATGTCAAATTCCTCCTGTCCCTCAATCTTCATTTTTATCTTCTATCAGA TGTCCAAAAAGCGCGCGCGGGTGGATGATGGCTTCGACCCCGTGTACCCCTACGATGCAGACAAC GCACCGACTGTGCCCTTCATCAACCCTCCCTTCGTCTCTTCAGATGGATTCCAAGAAAAGCCCCT GGGGGTGTTGTCCCTGCGACTGGCCGACCCCGTCACCACCAAGAATGGGGCTGTCACCCTCAAGC TGGGGGAGGGGGTGGACCTCGACGACTCGGGAAAACTCATCTCCAAAAATGCCACCAAGGCCACT GCCCCTCTCAGTATTTCCAACGGCACCATTTCCCTTAACATGGCTGCCCCTTTTTACAACAACAA TGGAACGTTAAGTCTCAATGTTTCTACACCATTAGCAGTATTTCCCACTTTTAACACTTTAGGTA TCAGTCTTGGAAACGGTCTTCAAACTTCTAATAAGTTGCTGACTGTACAGTTAACTCATCCTCTT ACATTCAGCTCAAATAGCATCACAGTAAAAACAGACAAAGGACTCTATATTAATTCTAGTGGAAA CAGAGGGCTTGAGGCTAACATAAGCCTAAAAAGAGGACTGATTTTTGATGGTAATGCTATTGCAA CATACCTTGGAAGTGGTTTAGACTATGGATCCTATGATAGCGATGGGAAAACAAGACCCATCATC ACCAAAATTGGAGCAGGTTTGAATTTTGATGCTAATAATGCCATGGCTGTGAAGCTAGGCACAGG TTTAAGTTTTGACTCTGCCGGTGCCTTAACAGCTGGAAACAAAGAGGATGACAAGCTAACACTTT GGACTACACCTGACCCAAGCCCTAATTGTCAATTACTTTCAGACAGAGATGCCAAATTTACCCTA TGTCTTACAAAATGCGGTAGTCAAATACTAGGCACTGTTGCAGTAGCTGCTGTTACTGTAGGTTC AGCACTAAATCCAATTAATGACACAGTAAAAAGCGCCATAGTATTCCTTAGATTTGACTCTGACG GTGTGCTCATGTCAAACTCATCAATGGTAGGTGATTACTGGAACTTTAGGGAAGGACAGACCACC CAAAGTGTGGCCTATACAAATGCTGTGGGATTCATGCCCAATCTAGGTGCATATCCTAAAACCCA AAGCAAAACACCAAAAAATAGTATAGTAAGTCAGGTATATTTAAATGGAGAAACTACTATGCCAA TGACACTGACAATAACTTTCAATGGCACTGATGAAAAAGACACAACACCTGTGAGCACTTACTCC ATGACTTTTACATGGCAGTGGACTGGAGACTATAAGGACAAGAATATTACCTTTGCTACCAACTC CTTTACTTTCTCCTACATGGCCCAAGAATAAACCCTGCATGCCAACCCCATTGTTCCCACCACTA TGGAAAACTCTGAAGCAGaAAAAAATAAAGTTCAAGTGTTTTATTGATTCAACAGTTTTCtcaca gaaccctagtattcaacctgccacctccctcccaacacacagagtacacagtcctttctccccgg ctggccttaaaaagcatcatatcatgggtaacagacatattcttaggtgttatattccacacggt ttcctgtcgagccaaacgctcatcagtgatattaataaactccccgggcagctcacttaagttca tgtcgctgtccagctgctgagccacaggctgctgtccaacttgcggttgcttaacgggcggcgaa ggagaagtccacgcctacatgggggtagagtcataatcgtgcatcaggatagggcggtggtgctg cagcagcgcgcgaataaactgctgccgccgccgctccgtcctgcaggaatacaacatggcagtgg tctcctcagcgatgattcgcaccgcccgcagcataaggcgccttgtcctccgggcacagcagcgc accctgatctcacttaaatcagcacagtaactgcagcacagcaccacaatattgttcaaaatccc acagtgcaaggcgctgtatccaaagctcatggcggggaccacagaacccacgtggccatcatacc acaagcgcaggtagattaagtggcgacccctcataaacacgctggacataaacattacctctttt ggcatgttgtaattcaccacctcccggtaccatataaacctctgattaaacatggcgccatccac caccatcctaaaccagctggccaaaacctgcccgccggctatacactgcagggaaccgggactgg aacaatgacagtggagagcccaggactcgtaaccatggatcatcatgctcgtcatgatatcaatg ttggcacaacacaggcacacgtgcatacacttcctcaggattacaagctcctcccgcgttagaac catatcccagggaacaacccattcctgaatcagcgtaaatcccacactgcagggaagacctcgca cgtaactcacgttgtgcattgtcaaagtgttacattcgggcagcagcggatgatcctccagtatg gtagcgcgggtttctgtctcaaaaggaggtagacgatccctactgtacggagtgcgccgagacaa ccgagatcgtgttggtcgtagtgtcatgccaaatggaacgccggacgtagtcatatttcctgaag caaaaccaggtgcgggcgtgacaaacagatctgcgtctccggtctcgccgcttagatcgctctgt gtagtagttgtagtatatccactctctcaaagcatccaggcgccccctggcttcgggttctatgt aaactccttcatgcgccgctgccctgataacatccaccaccgcagaataagccacacccagccaa cctacacattcgttctgcgagtcacacacgggaggagcgggaagagctggaagaaccatGATTAA CTTTATTCCAAACGGTCTCGGAGCACTTCAAAATGCAGGTCCCGGAGGTGGCACCTCTCGCCCCC ACTGTGTTGGTGGAAAATAACAGCCAGGTCAAAGGTGACACGGTTCTCGAGATGTTCCACGGTGG CTTCCAGCAAAGCCTCCACGCGCACATCCAGAAACAAGAGGACAGCGAAAGCGGGAGCGTTTTCT AATTCCTCAATCATCATATTACACTCCTGCACCATCCCCAGATAATTTTCATTTTTCCAGCCTTG AATGATTCGTATTAGTTCCTGAGGTAAATCCAAGCCAGCCATGATAAAAAGCTCGCGCAGAGCGC CCTCCACCGGCATTCTTAAGCACACCCTCATAATTCCAAGAGATTCTGCTCCTGGTTCACCTGCA GCAGATTAACAATGGGAATATCAAAATCTCTGCCGCGATCCCTAAGCTCCTCCCTCAACAATAAC TGTATGTAATCTTTCATATCATCTCCGAAATTTTTAGCCATAGGGCCGCCAGGAATAAGAGCAGG GCAAGCCACATTACAGATAAAGCGAAGTCCTCCCCAGTGWGCATTGCCAAATGTAAGATTGAAAT AAGCATGCTGGCTAGACCCTGTGATATCTTCCAGATAACTGGACAGAAAATCAGGCAAGCAATTT TTAAGAAAATCAACAAAAGAAAAGTCGTCCAGGTGCAGGTTTAGAGCCTCAGGAACAACGATGGA ATAAGTGCAAGGAGTGCGTTCCAGCATGGTTAGTGtTTTTTTGGTGATCTGTAGAACAAAAAATA AACATGCAATATTAAACCATGCTAGCCTGGCGAACAGGTGGGTAAATCACTCTTTCCAGCACCAG GCAGGCTACGGGGTCTCCGGCGCGACCCTCGTAGAAGCTGTCGCCATGATTGAAAAGCATCACCG AGAGACCTTCCCGGTGGCCGGCATGGATGATTCGAGAAGAAGCATACACTCCGGGAACATTGGCA TCCGTGAGTGAAAAAAaGCGACCTATAAAGCCTCGGGGCACTACAATGCTCAATCTCAATTCCAG CAAAGCCACCCCATGCGGATGGAGCACAAAATTGGCAGGTGCGTAAAAAATGTAATTACTCCCCT CCTGCACAGGCAGCAAAGCCCCCGCTCCCTCCAGAAACACATACAAAGCCTCAGCGTCCATAGCT TACCGAGCACGGCAGGCGCAAGAGTCAGAGAAAAGGCTGAGCTCTAACCTGACTGCCCGCTCCTG TGCTCAATATATAGCCCTAACCTACACTGACGTAAAGGCCAAAGTCTAAAAATACCCGCCAAAAT GACACACACGCCCAGCACACGCCCAGAAACCGGTGACACACTCAAAAAAATACGTGCGCTTCCTC AAACGCCCAAACCGGCGTCATTTCCGGGTTCCCACGCTACGTCACCGCTCAGCGACTTTCAAATT CCGTCGACCGTTAAAAACGTCACTCGCCCCGCCCCTAACGGTCGCCCTTCTCTCGGCCAATCACC TTCCTCCCTTCCCAAATTCAAACGCCTCATTTGCATATTAACGCGCACAAAAAGTTTGAGGTATA TATTTGAATGATG
ChAdOx2 Sequence (SEQ ID NO: 67+68)

(52) The ChAdOx2 sequence 5′ to the immunogen cassette is provided as SEQ ID NO: 67 and the ChAdOx2 sequence 3′ to the immunogen cassette is provided as SEQ ID NO: 68.

(53) MVA Sequence (SEQ ID NO: 69+70)

(54) The MVA sequence 5′ to the immunogen cassette is provided as SEQ ID NO: 69 and the MVA sequence 3′ to the immunogen cassette is provided as SEQ ID NO: 70.

(55) MVA vaccines have been made using two different shuttle plasmids: 1. P7.5 shuttle plasmid. HPV insert with upstream and downstream flanks that are homologous to regions of the TK locus in parental MVA virus. Insert under control of p7.5 promoter. 2. F11 shuttle plasmid. HPV insert with upstream and downstream flanks that are homologous to regions of the F11 locus in parental MVA virus. Insert under control of F11 promoter.

(56) Chicken embryo fibroblast cells are then infected with MVA parental virus and transfected with either p7.5 or F11 MVA shuttle plasmids to allow homologous recombination with the MVA genome. So you get parental MVA with the gene of interest inserted into the MVA genome at either the TK locus (p7.5 shuttle plasmid) or F11 locus (F11 shuttle plasmid). Resulting in two versions of the MVA vaccine.

(57) P7.5 Shuttle Plasmid (SEQ ID NO: 158) (Insert Underlined)

(58) TABLE-US-00014 agcgcccaatacgcaaaccgcctctccccgcgcgttggccgattcattaatgcagctggcacgacaggtttcccgactggaa agcgggcagtgagcgcaacgcaattaatgtgagttagctcactcattaggcaccccaggctttacactttatgcttccggct cgtatgttgtgtggaattgtgagcggataacaatttcacacaggaaacagctatgaccatgattacgccaagcttgcatgcA TCTGGAAACGGGCATCTCCATTTAAGACTAGAtGCCACGGGGTTTAAAATACTAATCATGACATTTTGTAGAGCGTAATTAC TTAGTAAATCCGCCGTACTAGGTTCATTTCCTCCTCGTTTGGATCTCACATCAGAAATTAAAATAATCTTAGAAGGATGCAG TTGTTTTTTGATGGATCGTAGATATTCCTCATCAACGAACCGAGTCACTAGAGTCACATCACGCAATCCATTTAAAATAGGA TCATGATGGCGGCCGTCAATTAGCATCCATTTGATGATCACTCCTAAATTATAGAAATGATCTCTCAAATAACGTATATGTG TACCGGGAGCAGATCCTATATACACTACGGTGGCACCATCTAATATACCGTGTCGCTGTAACTTACTAAGAAAAAATAATTC TCCTAGTAATAGTTTTAACTGTCCTTGATACGGtAGTTTTTTTGCGACCTCATTTGCACTTTCTGGTTCGTAATCTAACTCA TTATCAATTTCCTCAAAATACATAAACGGTTTATCTAACGACACAACATCCATTTTTAAGTATTATATTAAAATTTAATCAA TGTTTATTTTTAGTTTTTTAGATAAAAAATATAATATTATGAGTCGATGTAACACTTTCTACACACCGATTGATACATATCA TTACCTCCTATTATcTCTATCTCGGTTTCCTCACCCAATCGTTTAGAAAAGGAAGCCTCCTTAAAGCATTTCATACACACAG CAGTTAGTTTTACCACCATTTCAGATAATGGAATAAGATTCAAAATATTATTAAACGGTTTACGTTGAAATGTCCCATCGAG TGCGGCTACTATAACTATTTTTCCTTCGTTTGCCaTACAGATCCTACGTACTCGAGCGGCCGCTTATCAGGTCCGGGTGGAG TCCAGGCCCAGCAGTGGATTGGGGATAGGCTTGCCAGAGGCGCCAGGTCCAGAGCCGGCGATTCTGGCCTCGCACTTGCAGC ACATACACAGCATGGTGTGTCTCTGAGGCTCGGCCCTTCTAGCGGGCAGATGCTGGTGGTTCACGCCGTCGATCTCGTCGTT CTCTTCCACCAGAGATTCGCATCTGCAGCACTGTGTCTCGATCAGATAGCAAGGGTGCTGTTCGTCCCGTCTAGCCTGCTGG GGCTGTTCCTGCAGATGGTCCACTTCGTCCTCATCCTCGTCCCCATCCAGGCCGCCAGTGTCCTCTTCATCGGAGCTGTCTC CCAGCTGCTCATAACAGTGCAGATCAGTGGTTTCAGGCTGCTCGTAGCAGTACAGGTCGGTTGTCTCGGGCTGCAGATCCAG CATGTACTCGTGCAGGGTGTGGAACCGCTTGTTCAGGTCCACGTGTCTTTTCTTTTCCTGCGGACACAGTGGCCGCTGGCAG TCGTACACCTCAGATCTCTGCAGGGTTTTCTTGCATTCCACGCACAGTGTGGTGCCATACACGGAATATCTGTACCACCGGA ACTCGGACACCTTGGAGTCGCGATACACGATTGTCAGGTCTGTGAAGGCGAAATCCAGCACCTCTGTCTCGGTCAGCTGTCC CTTGCAATACACCAGGCTGGCGCCATACACAGAGCAGTTGTAGTACCTCAGCTTCCGCACTTTGCTGTCCCGATACACCACC CGCAGATCGGTGTAGGCGAAGTTGTACACCTCGCTGGCTGTCAGGGCCTTCTTGCAGAACACCCGCAGGCATCTAATCAGCA GGTTGTACAGGCCAGTGTTGGTCAGCTTTTCCAGGGTATCGCCGTACACGGAGTCGCTGTAGTGCCGCAGCTCTCTGATTCT GGAGTAGAAGTCGATACACTTGTGGCAGGCGGCGTGGGGGATGGAGTCTCTGTACACCACGTTGATGCACCGAATCAGCAGA TCGCACAGGGGCTTGTTGTACTGCTGTTCCAGGGTGGTGCCGTACAGGCTGTAGCAGTAGTGCCGGTACTCGCTGATCTTGC TGTAGAACTTCAGGCACTTGTCGCACACGGCGTAAGGATTGCCATCCCGGTACACGATGGCGGTGGCGGGGCTGGTAATCAC GACGATGTACACGAACACCAGCACCCAGGCATAGGCACACATGCACACGCTGGGCAGCAGGCTTCCGATGGACACCCACAGC AGCAGCACCAGCACCAGCACCTGAGCGTACACGCTGATAGACAGCAGCAGAGGCCTCAGGTAGGTGGACACACTCAGCAGCA GGGGTCTGATCAGCAGGCACACGCACAGCAGCACACAAAAGCACAGCAGGAAGCAAGGGGCCCAAGGTCTTGGAGGAGGTGG AGGGGGCACCCATGGACAGTGTGGAGGTCTAGGAGGTGCCCAGGGGCAAGGGGCAGGGATTCTAGGGGCCCATGGAGAAGGC TTAGGGATGGGGGGCCTCTGAGGAGCCCAAGGACATGGAGCAGGGATCCGGTGAGGGGGGGTGCTGTAGCTGTTCAGCAGTG ACAGCAGTGGGTATCTGGTGGTCAGGTGCAGCCTGATCACGACTGTGCTCTTGGGGGTGGTCACTCTCAGTTCCACCAGGGA GGTATTCTCGGGGGTGGTGGTCTGGGTGGTCAGCAGTTTCAGCAGAGGATATGTTGGATCCAGAGGCACGGGGCACAGGGTG GGCACGATGAACACCTTGTTCTCCCAGATGCACTTGCCGTGGGCCTTCACGCCCATGTTGGGGGGTCTGGACAGCAGCTTCA GCAGGGGGTACTTGGTCACGAGCTGAGACTGATCCTGGTCGCTGGACAGCCGCCGTCTGGCCTTGTAAAAAATGGCACATTC CAGGCGAATCAGCTTCCAATAGTCGATATGGTCCTTCACGAGCTCGGTGGCGGACACGTTGTCGTCGAAGGTGCTGCACATG GAGTCGTTGCAGTCGATGCTGTTGCCGAAATGCACTTCCCAGGTGCCCTTGCAGCCGTACTTCTCGGCCTCGGTCTTGCACC AGCCATCGTCGCCGCAGTAGTACACGCTGTCCCAGGCCACGTAGTCGAACCACACTTCGATGTGCTGGCCGCCCTTCTTGAA GCAGTGCTTGGGCTCGGTGTTCCACTCGATGGCTTTACAGGCCTTGGCCTTGCAGATATTCAGGGCGGGCACCACCTGGTGT CTGGCGGCGAAGAAGATGGCGTTTTCCTGCCTGATGGCTTTCCAATAATCAATGTGGTCGGCTTCCTCGGTGCTGATCTCAT CGGAGGGGATGCTGGCGGGGCACACGATCACGTAGATTTCTTTCCAATTTGTGTAATCCATGGTATTGGCCTTGTCATTGTC GTACTGCACGGTGATGGTGATGCCGTGCTTCTTAAACTGGGGCTCGGCCAGCCACATTTCCAGGCTGGTCTGCTGCAGGGTC CACTCATCGTAGGGGCTGGCATTCAGGGCTTCCAGGGCCAGCTGCAGTTCGATGGCCTGGCAGGCTTTGGCTTTAGAGGCGG CCAGTGGAGGCACCACCTGGTGGCAGATGCTGATGCCCAGCTCTTTGGCCTTATAGAAGATTGCACATTCCATCCGGATCAG TTTCCAGTGCTCGATCTGGGCGTTCAGGTCGTTCTTGTCGGCCTCGTAGTAGGTCAGGGTCACAATGGCGTTCTTGTGTTTC CCATCGTGACATGTCCAATGCCACTTGTGCTTGCCGTCGTGGCAGGTCCAGTGCCAGGTGCTGCTCAGCTTGCAGTGCTTCT TGAATCTGTACCGCAGGCACTTCAGGATCAGCAGCTTGTTGGGGTGGCAGTTCTCGCTTCTGGGCCTCTTGATCCGCCGCTG GCCGCTCTCAGGACACAGGATCACTTGGCCGCCAGCGTGCACCTCCCATTTCTTGTCCACCTGGCCTTCCACCACGGTGCAC TGGGCGTCCTCGCAGATATAGATCCAGTTGGTGTAGTGCATGGTGTTGCAGATGTCGCCGTCGAACTGGTGGAAGCCCATCT CGCGAGCCTTATACATAATAGCACATTCCAGTCTGATCCGGGCCTTGTACATGATGGCGCATTCCAGCCGGATGTGCTTCCA GTAGTCGATGTGATCGCAGATGTGGTCGCACAGGTCCTTGGAATCATTCTCATAATGTTCCAGAATGTCCTTGCTGTCGTTC TCGTAGTGTTCCAGGATCTTGTCCTGGCACACGTTGAAGGGGTTCAGAAACTGCAGCACGTGGATCCGGGAGTGCAGGTATC TCAGAAAGGCATTGGGGAACTCGAACACGGTGATCCGGCTTTCCAGGTAAGGCCAGAAGGGGTTGGGGAAGGTAAACACCAC CAGTCTGCTGTGCAGGTAGGGCCACAGAGACATGGCAAAGCAGGACTTGCCTGTGTTAGGTGGGCCGTAGATCACGAGACAA TTCAGGGACATGCCGAAGTAGGACTTTCCGGTATTGGCTGGGCCGCACAGCACCAGGCAGTTCAGGCTCATGCCGAACAGGC TCTTGCCGGTGTTGGCAGCGCCGTACAGCAGGATGCAGTTCTTCAGAAAAGCAGCGGCGTTGCTGTTCACGTCTGCCAGCTG AGCCTTCAGGAAGGCGCAGGCATTGCTGTCGCTGTCAGCCAGCTGGGCGGAGTTGTCGATAAAGCCGTCCAGGTCGCTCTCG GTGCTCTCTTCGTCGGTTTCGTCGTTGTCGATGAAATCCACCATGTCCTCGCCGGTGTCGGAGTCGTTCTCATTCTCGTCGC TGTCGTCGATGAAGTCGATCAGGTCGGTGCCGCTGTCGTAGGCTGTCTCGTCCTCGTCGGCCAGCTTGCTGCCTCTTCTGAA CCGGGCGTGGATTTCCTGGCTGGGGGACACAAACACGGCGCCACACAGCAGCAGCACGCAGCACAGGCCCCTCTTCATAGCA TCCATGGTGGCGGCGCGGCTAGCGGTACCGgatctagatGGGGATCCGTCACtGTTCTTTATGATTCTACTTCCTTACCGTG CAATAAATTAGAATATATTTTCTACTTTTACGAGAAATTAATTATTGTATTTATTATTTATGGGTGAAAAACTTACTATAAA AAGCGGGTGGGTTTGGAATTAGTGATCAGTTTATGTATATCGCAACTACCGGgCATATGGCTATCGACATCGAGAACATTAC CCACATGATAAGAGATTGTATCAGTTTCGTAGTCTTGAGTATTGGTATTACTATATAGTATATagatGTCGACCTGcaggtc GACGAAGTTCCTATACTTTCTAGAGAATAGGAACTTCGCAGCCAAGCTGGAATTcaTCCACTTTGGATAAGAAATCTGCATG ATAAATATATTGATATCCTACCACCTATTAAAGTACCATTATCTAATAGCAATAAGATAGATAAACAAATGTTTTTTGATGA AGTTATTACGTGGATAAATATATATCTTCAGGAAAAGGGTATTATGTTACCAGATGATATAAGAGAACTCAGAGATGCTATT ATTCCTTAACTAGTTACGTCTCTTTAGGTACTTATTTTGATACGTTACAAGTAAAAAACTATCAAATATAAATGGAATCTGA TTCTAATATAGCGATTGAAGAggaTCCACCGGTCGCCACCATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCC ATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCA AGCTGACCCTGAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTACGGCGT GCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAG CGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCA TCGAGCTGAAGGGCATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAACGT CTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCACTACCTGAGCACCCAGT CCGCCCTGAGCAAAGACCCCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGG CATGGACGAGCTGTACAAGTAAAGCGGccgcgaagttcctatactttctagagaataggaacTTCAACAATGTCTGGAAAGA ACTGTCCTTCATCGATACCTATCACGGAGAAATCTGTAATTGATTCCAAGAcATCACATAGTTTAGTTGCTTCCAATGCTTC AAAATTATTCTTATCATGCGTCCATAGTCCCGTTCCGTATCTATTATCGTTAGAATATTTTATAGTCACGCATTTATATTGA GCTATTTGATAACGTCTAACTCGTCTAATTAATTCTGTACTTTTACCTGAAAACATGGGGCCGATTATCAACTGAATATGTC CGCCGTTCATGATGACAATAAAGAATTAATTATTGTTCACTTTATTCGACTTTAATATATCCATCACGTTAGAAAATGCGAT ATcGCGACGAGGATCTATGTATCTAACAGGATCTATTGCGGTGGTAGCTAGAGctGATTCTTTTTTGAATCGCATCAAACTA ATCACAAAGTCGAACAAATATCCTTTATTAAGTTTGACCCTTCCATCTGTAACAATAGGGACCTTGTTAAACAGTTTTTTAA AATCTTGAgAGTCTGTGAATTTTGTCAATTGTCTGTATTCCTCTGAAAGAGATTCATAACAATGACCCACGGCTTCTAATTT ATTTTTTGATTGGATCAATAATAATAACAGAAAGTCTAGATATTGAGTGATTTGCAATATATCAGATAATGAAGATTCATCA TCTTGACTAGCCAAATACTTAAAAAATGAATCATCATCTGCGAAGAACATCGTTAAGAGATACTGGTTGTGATCCATTTATg agctcgcgaaagcttggcactggccgtcgttttacaacgtcgtgactgggaaaaccctggcgttacccaacttaatcgcctt gcagcacatccccctttcgccagctggcgtaatagcgaagaggcccgcaccgatcgcccttcccaacagttgcgcagcctga atggcgaatggcgcctgatgcggtattttctccttacgcatctgtgcggtatttcacaccgcatatggtgcactctcagtac aatctgctctgatgccgcatagttaagccagccccgacacccgccaacacccgctgacgcgccctgacgggcttgtctgctc ccggcatccgcttacagacaagctgtgaccgtctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacgcg cgagacgaaagggcctcgtgatacgcctatttttataggttaatgtcatgataataatggtttcttagacgtcaggtggcac ttttcggggaaatgtgcgcggaacccctatttgtttatttttctaaatacattcaaatatgtatccgctcatgagacaataa ccctgataaatgcttcaataatattgaaaaaggaagagtatgagtattcaacatttccgtgtcgcccttattcccttttttg cggcattttgccttcctgtttttgctcacccagaaacgctggtgaaagtaaaagatgctgaagatcagttgggtgcacgagt gggttacatcgaactggatctcaacagcggtaagatccttgagagttttcgccccgaagaacgttttccaatgatgagcact tttaaagttctgctatgtggcgcggtattatcccgtattgacgccgggcaagagcaactcggtcgccgcatacactattctc agaatgacttggttgagtactcaccagtcacagaaaagcatcttacggatggcatgacagtaagagaattatgcagtgctgc cataaccatgagtgataacactgcggccaacttacttctgacaacgatcggaggaccgaaggagctaaccgcttttttgcac aacatgggggatcatgtaactcgccttgatcgttgggaaccggagctgaatgaagccataccaaacgacgagcgtgacacca cgatgcctgtagcaatggcaacaacgttgcgcaaactattaactggcgaactacttactctagcttcccggcaacaattaat agactggatggaggcggataaagttgcaggaccacttctgcgctcggcccttccggctggctggtttattgctgataaatct ggagccggtgagcgtgggtctcgcggtatcattgcagcactggggccagatggtaagccctcccgtatcgtagttatctaca cgacggggagtcaggcaactatggatgaacgaaatagacagatcgctgagataggtgcctcactgattaagcattggtaact gtcagaccaagtttactcatatatactttagattgatttaaaacttcatttttaatttaaaaggatctaggtgaagatcctt tttgataatctcatgaccaaaatcccttaacgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaaggat cttcttgagatcctttttttctgcgcgtaatctgctgcttgcaaacaaaaaaaccaccgctaccagcggtggtttgtttgcc ggatcaagagctaccaactctttttccgaaggtaactggcttcagcagagcgcagataccaaatactgttcttctagtgtag ccgtagttaggccaccacttcaagaactctgtagcaccgcctacatacctcgctctgctaatcctgttaccagtggctgctg ccagtggcgataagtcgtgtcttaccgggttggactcaagacgatagttaccggataaggcgcagcggtcgggctgaacggg gggttcgtgcacacagcccagcttggagcgaacgacctacaccgaactgagatacctacagcgtgagctatgagaaagcgcc acgcttcccgaagggagaaaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgcacgagggagcttccag ggggaaacgcctggtatctttatagtcctgtcgggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtcagg ggggcggagcctatggaaaaacgccagcaacgcggcctttttacggttcctggccttttgctggccttttgctcacatgttc tttcctgcgttatcccctgattctgtggataaccgtattaccgcctttgagtgagctgataccgctcgccgcagccgaacga ccgagcgcagcgagtcagtgagcgaggaagcggaaga
F11-HPV Shuttle Plasmid (SEQ ID NO: 159) (Vaccine Construct Insert is Underlined)

(59) TABLE-US-00015 AGCGCCCAATACGCAAACCGCCTCTCCCCGCGCGTTGGCCGATTCATTAATGCAGCTGGCACGAC AGGTTTCCCGACTGGAAAGCGGGCAGTGAGCGCAACGCAATTAATGTGAGTTAGCTCACTCATTA GGCACCCCAGGCTTTACACTTTATGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAAC AATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATA CTCAAGCTATGCATCAAGCTTGGTACCGAGCTCGGATCCACTAGTAACGGCCGCCAGTGTGCTGG AATTCGCCCTTgtaatctattcgatataccgttgctaacagtatactggcccaataactgtggat ggaaaatctataataatacattaatatcatccgatggtgctagggttatttggatggatgcgtat aaattttcttgcggtttatctttacaagactattgttatcattggggtagcaaaccagagagccg accattcgatttaataaaaaaatcagatgctaaacgcaattctaaatcgttggtcaaagaatcta tggcatccttgaaatccttgtacgaggcattcgagacacaatcaggagcgttagaagttttaatg agtccatgtaggatgttttcgttttctagaatagaagacatgttcttaactagtgtcattaatag agtatccgagaatactggaatggggatgtattatcctaccaacgatataccttctctatttatcg aatcatctatctgtctagattatattatagtaaataatcaggaatccaacaaatatcgtatcaaa tctgttctcgatatcatttcttcaaaacaataccctgcaggacgtcccaactacgttaaaaatgg tacaaaaggaaagttatatatcgcgttgtgtaaagttaccgtacctactaacgaccatattccag tagtttatcacgatgatgacaatactaccacctttattacagtattgacgtccgtcgatattgaa actgctatcagagcaggatattcgatagtcgaattaggggctttacaatgggataataatattcc agaacttaaaaacggtttactggatagtatcaagatgatttatgacttgaacgcagttacaacaa ataatttattggaacagctcatagaaaatattaactttaacaactctagtataatttcgttgttt tatacatttgccattagttattgccgagcattcatttactcaattatggaaaccatagatccggt gtatatatctcagttcagttataaagaattatacgttagtagctcttataaagatattaatgaat ccatgagtcagatggtaaaattataaaaagtgaaaaacaatattatttttatcgttggttgttac actATGGATGCTATGAAGAGGGGCCTGTGCTGCGTGCTGCTGCTGTGTGGCGCCGTGTTTGTGTC CCCCAGCCAGGAAATCCACGCCCGGTTCAGAAGAGGCAGCAAGCTGGCCGACGAGGACGAGACAG CCTACGACAGCGGCACCGACCTGATCGACTTCATCGACGACAGCGACGAGAATGAGAACGACTCC GACACCGGCGAGGACATGGTGGATTTCATCGACAACGACGAAACCGACGAAGAGAGCACCGAGAG CGACCTGGACGGCTTTATCGACAACTCCGCCCAGCTGGCTGACAGCGACAGCAATGCCTGCGCCT TCCTGAAGGCTCAGCTGGCAGACGTGAACAGCAACGCCGCTGCTTTTCTGAAGAACTGCATCCTG CTGTACGGCGCTGCCAACACCGGCAAGAGCCTGTTCGGCATGAGCCTGAACTGCCTGGTGCTGTG CGGCCCAGCCAATACCGGAAAGTCCTACTTCGGCATGTCCCTGAATTGTCTCGTGATCTACGGCC CACCTAACACAGGCAAGTCCTGCTTTGCCATGTCTCTGTGGCCCTACCTGCACAGCAGACTGGTG GTGTTTACCTTCCCCAACCCCTTCTGGCCTTACCTGGAAAGCCGGATCACCGTGTTCGAGTTCCC CAATGCCTTTCTGAGATACCTGCACTCCCGGATCCACGTGCTGCAGTTTCTGAACCCCTTCAACG TGTGCCAGGACAAGATCCTGGAACACTACGAGAACGACAGCAAGGACATTCTGGAACATTATGAG AATGATTCCAAGGACCTGTGCGACCACATCTGCGATCACATCGACTACTGGAAGCACATCCGGCT GGAATGCGCCATCATGTACAAGGCCCGGATCAGACTGGAATGTGCTATTATGTATAAGGCTCGCG AGATGGGCTTCCACCAGTTCGACGGCGACATCTGCAACACCATGCACTACACCAACTGGATCTAT ATCTGCGAGGACGCCCAGTGCACCGTGGTGGAAGGCCAGGTGGACAAGAAATGGGAGGTGCACGC TGGCGGCCAAGTGATCCTGTGTCCTGAGAGCGGCCAGCGGCGGATCAAGAGGCCCAGAAGCGAGA ACTGCCACCCCAACAAGCTGCTGATCCTGAAGTGCCTGCGGTACAGATTCAAGAAGCACTGCAAG CTGAGCAGCACCTGGCACTGGACCTGCCACGACGGCAAGCACAAGTGGCATTGGACATGTCACGA TGGGAAACACAAGAACGCCATTGTGACCCTGACCTACTACGAGGCCGACAAGAACGACCTGAACG CCCAGATCGAGCACTGGAAACTGATCCGGATGGAATGTGCAATCTTCTATAAGGCCAAAGAGCTG GGCATCAGCATCTGCCACCAGGTGGTGCCTCCACTGGCCGCCTCTAAAGCCAAAGCCTGCCAGGC CATCGAACTGCAGCTGGCCCTGGAAGCCCTGAATGCCAGCCCCTACGATGAGTGGACCCTGCAGC AGACCAGCCTGGAAATGTGGCTGGCCGAGCCCCAGTTTAAGAAGCACGGCATCACCATCACCGTG CAGTACGACAATGACAAGGCCAATACCATGGATTACACAAATTGGAAAGAAATCTACGTGATCGT GTGCCCCGCCAGCATCCCCTCCGATGAGATCAGCACCGAGGAAGCCGACCACATTGATTATTGGA AAGCCATCAGGCAGGAAAACGCCATCTTCTTCGCCGCCAGACACCAGGTGGTGCCCGCCCTGAAT ATCTGCAAGGCCAAGGCCTGTAAAGCCATCGAGTGGAACACCGAGCCCAAGCACTGCTTCAAGAA GGGCGGCCAGCACATCGAAGTGTGGTTCGACTACGTGGCCTGGGACAGCGTGTACTACTGCGGCG ACGATGGCTGGTGCAAGACCGAGGCCGAGAAGTACGGCTGCAAGGGCACCTGGGAAGTGCATTTC GGCAACAGCATCGACTGCAACGACTCCATGTGCAGCACCTTCGACGACAACGTGTCCGCCACCGA GCTCGTGAAGGACCATATCGACTATTGGAAGCTGATTCGCCTGGAATGTGCCATTTTTTACAAGG CCAGACGGCGGCTGTCCAGCGACCAGGATCAGTCTCAGCTCGTGACCAAGTACCCCCTGCTGAAG CTGCTGTCCAGACCCCCCAACATGGGCGTGAAGGCCCACGGCAAGTGCATCTGGGAGAACAAGGT GTTCATCGTGCCCACCCTGTGCCCCGTGCCTCTGGATCCAACATATCCTCTGCTGAAACTGCTGA CCACCCAGACCACCACCCCCGAGAATACCTCCCTGGTGGAACTGAGAGTGACCACCCCCAAGAGC ACAGTCGTGATCAGGCTGCACCTGACCACCAGATACCCACTGCTGTCACTGCTGAACAGCTACAG CACCCCCCCTCACCGGATCCCTGCTCCATGTCCTTGGGCTCCTCAGAGGCCCCCCATCCCTAAGC CTTCTCCATGGGCCCCTAGAATCCCTGCCCCTTGCCCCTGGGCACCTCCTAGACCTCCACACTGT CCATGGGTGCCCCCTCCACCTCCTCCAAGACCTTGGGCCCCTTGCTTCCTGCTGTGCTTTTGTGT GCTGCTGTGCGTGTGCCTGCTGATCAGACCCCTGCTGCTGAGTGTGTCCACCTACCTGAGGCCTC TGCTGCTGTCTATCAGCGTGTACGCTCAGGTGCTGGTGCTGGTGCTGCTGCTGTGGGTGTCCATC GGAAGCCTGCTGCCCAGCGTGTGCATGTGTGCCTATGCCTGGGTGCTGGTGTTCGTGTACATCGT CGTGATTACCAGCCCCGCCACCGCCATCGTGTACCGGGATGGCAATCCTTACGCCGTGTGCGACA AGTGCCTGAAGTTCTACAGCAAGATCAGCGAGTACCGGCACTACTGCTACAGCCTGTACGGCACC ACCCTGGAACAGCAGTACAACAAGCCCCTGTGCGATCTGCTGATTCGGTGCATCAACGTGGTGTA CAGAGACTCCATCCCCCACGCCGCCTGCCACAAGTGTATCGACTTCTACTCCAGAATCAGAGAGC TGCGGCACTACAGCGACTCCGTGTACGGCGATACCCTGGAAAAGCTGACCAACACTGGCCTGTAC AACCTGCTGATTAGATGCCTGCGGGTGTTCTGCAAGAAGGCCCTGACAGCCAGCGAGGTGTACAA CTTCGCCTACACCGATCTGCGGGTGGTGTATCGGGACAGCAAAGTGCGGAAGCTGAGGTACTACA ACTGCTCTGTGTATGGCGCCAGCCTGGTGTATTGCAAGGGACAGCTGACCGAGACAGAGGTGCTG GATTTCGCCTTCACAGACCTGACAATCGTGTATCGCGACTCCAAGGTGTCCGAGTTCCGGTGGTA CAGATATTCCGTGTATGGCACCACACTGTGCGTGGAATGCAAGAAAACCCTGCAGAGATCTGAGG TGTACGACTGCCAGCGGCCACTGTGTCCGCAGGAAAAGAAAAGACACGTGGACCTGAACAAGCGG TTCCACACCCTGCACGAGTACATGCTGGATCTGCAGCCCGAGACAACCGACCTGTACTGCTACGA GCAGCCTGAAACCACTGATCTGCACTGTTATGAGCAGCTGGGAGACAGCTCCGATGAAGAGGACA CTGGCGGCCTGGATGGGGACGAGGATGAGGACGAAGTGGACCATCTGCAGGAACAGCCCCAGCAG GCTAGACGGGACGAACAGCACCCTTGCTATCTGATCGAGACACAGTGCTGCAGATGCGAATCTCT GGTGGAAGAGAACGACGAGATCGACGGCGTGAACCACCAGCATCTGCCCGCTAGAAGGGCCGAGC CTCAGAGACACACCATGCTGTGTATGTGCTGCAAGTGCGAGGCCAGAATCGCCGGCtaattttta taaccgagtttctgcattattgtaattcgtatgctggcaccatcaaagaatcacttctaaaagat atcaatatcacacatacaaatattactaccctattgaatgagacagccaaggttatcaagttagt aaaatctctggtagataaagaagatactgatattgtgaataatttcattaccaaagaaattaaaa acagagacaaaatagttaatagtttgtctctatcaaacctggactttcgtttgtaaattggggct Ttttgtacaataaatgggtgttgccaatgattcatcccctgaatatcaatggatgtctccccata gattatcagatactgttatattaggagactgtttgtattttaacaatataatgtcccaattagat ttacaccaaaattgggctccatcagttagattgttaaattattttaagaattttaataaggaaac actactaaagatagaagagaatgattacattaattcatcctttttccaacaaaaggataaacgat tttatcctataaacgacgatttttatcacatatctacaggaggatatggtatagtctttaagata gataactatgtagtaaaatttgtattcgaggccacaaaattatatagtcccatggaaactacggc ggagttcacagtacccaaatttctatacaacaatctaaagggagatgaaaaaaaattaatcgtgt gtgcgtgggccatgggattaaactataaattaacatttttacatactctgtataaacgtgttctt catatgttgctattattgatacaaactatggatggtcaggaactatcattgagatattcttctaa agtttttttaaaggcgtttaacgagagaaaggacagtatcaaattcgtgaaattactatcccact tttatccggcagttattaacagtaatattaatgttataaactattttaaccgcatgtttcacttt ttcgaacatgaaaagagaactaactacgaatacgaaagaggaaatattataatttttcccctagc actgtattcggcagataaagtagataccgagctagctatcaaattaggatttaaatctttggtac aatacataaagtttatctttttacagatggctctgttatacattaaaatttacgaactaccatgc tgcgacaactttttacacgcagatcttaaacccgataatatcttactttttgattccaatgaacc aataataattcatctaaaggataaaaagtttgtttttaatgaacgtattaaatcggcattaaacg actttgacttttcccaagAAGGGCGAATTCTGCAGATATCCATCACACTGGCggccgcTTACTTG TACAGCTCGTCCATGCCGAGAGTGATCCCGGCGGCGGTCACGAACTCCAGCAGGACCATGTGATC GCGCTTCTCGTTGGGGTCTTTGCTCAGGGCGGACTGGGTGCTCAGGTAGTGGTTGTCGGGCAGCA GCACGGGGCCGTCGCCGATGGGGGTGTTCTGCTGGTAGTGGTCGGCGAGCTGCACGCTGCCGTCC TCGATGTTGTGGCGGATCTTGAAGTTCACCTTGATGCCGTTCTTCTGCTTGTCGGCCATGATATA GACGTTGTGGCTGTTGTAGTTGTACTCCAGCTTGTGCCCCAGGATGTTGCCGTCCTCCTTGAAGT CGATGCCCTTCAGCTCGATGCGGTTCACCAGGGTaTCGCCCTCGAACTTCACCTCGGCGCGGGTC TTGTAGTTGCCGTCGTCCTTGAAGAAGATGGTGCGCTCCTGGACGTAGCCTTCGGGCATGGCGGA CTTGAAGAAGTCGTGCTGCTTCATGTGGTCGGGGTAGCGGCTGAAGCACTGCACGCCGTAGGTCA GGGTGGTCACGAGGGTcGGCCAGGGCACGGGCAGCTTGCCGGTGGTGCAGATGAACTTCAGGGTC AGCTTGCCGTAGGTGGCATCGCCCTCGCCCTCGCCGGACACGCTGAACTTGTGGCCGTTTACGTC GCCGTCCAGCTCGACCAGGATGGGCACCACCCCGGTaAACAGCTCCTCGCCCTTGCTCACCATgt ttaaacTTTATATTCCAAAAAAAAAAAATAAAATTTCAATTTTTgtttaaacgttGTACGGCAGT TTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATT ATTGACACGCCGGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGT CTCCCGTGAACTTTACCCGGTGGTGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATA TGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTGGCTGATCTCAGCCACCGCGAAAATGAC ATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAAATGTCAGGCATGAGATTATCAAAAAG GATCTTCACCTAGATCCTTTTCACGTAGAAAGCCAGTCCGCAGAAACGGTGCTGACCCCGGATGA ATGTCAGCTACTGGGCTATCTGGACAAGGGAAAACGCAAGCGCAAAGAGAAAGCAGGTAGCTTGC AGTGGGCTTACATGGCGATAGCTAGACTGGGCGGTTTTATGGACAGCAAGCGAACCGGAATTGCC AGCTGGGGCGCCCTCTGGTAAGGTTGGGAAGCCCTGCAAAGTAAACTGGATGGCTTTCTCGCCGC CAAGGATCTGATGGCGCAGGGGATCAAGCTCTGATCAAGAGACAGGATGAGGATCGTTTCGCATG ATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGA CTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCC CGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAAGACGAGGCAGCGCGG CTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGG AAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTG CCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGC CCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGT CGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCA AGGCGAGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATC ATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTA TCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCT TCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGAC GAGTTCTTCTGAATTATTAACGCTTACAATTTCCTGATGCGGTATTTTCTCCTTACGCATCTGTG CGGTATTTCACACCGCATACAGGTGGCACTTTTCGGGGAAATGTGCGCGGAACCCCTATTTGTTT ATTTTTCTAAATACATTCAAATATGTATCCGCTCATGAGACAATAACCCTGATAAATGCTTCAAT AATAGCACGTGAGGAGGGCCACCATGGCCAAGTTGACCAGTGCCGTTCCGGTGCTCACCGCGCGC GACGTCGCCGGAGCGGTCGAGTTCTGGACCGACCGGCTCGGGTTCTCCCGGGACTTCGTGGAGGA CGACTTCGCCGGTGTGGTCCGGGACGACGTGACCCTGTTCATCAGCGCGGTCCAGGACCAGGTGG TGCCGGACAACACCCTGGCCTGGGTGTGGGTGCGCGGCCTGGACGAGCTGTACGCCGAGTGGTCG GAGGTCGTGTCCACGAACTTCCGGGACGCCTCCGGGCCGGCCATGACCGAGATCGGCGAGCAGCC GTGGGGGCGGGAGTTCGCCCTGCGCGACCCGGCCGGCAACTGCGTGCACTTCGTGGCCGAGGAGC AGGACTGACACGTGCTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGAT AATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTTCCACTGAGCGTCAGACCCCGTAGAAAA GATCAAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAAC CACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAACTCTTTTTCCGAAGGTAACT GGCTTCAGCAGAGCGCAGATACCAAATACTGTCCTTCTAGTGTAGCCGTAGTTAGGCCACCACTT CAAGAACTCTGTAGCACCGCCTACATACCTCGCTCTGCTAATCCTGTTACCAGTGGCTGCTGCCA GTGGCGATAAGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGG TCGGGCTGAACGGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACTGAG ATACCTACAGCGTGAGCTATGAGAAAGCGCCACGCTTCCCGAAGGGAGAAAGGCGGACAGGTATC CGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGAGGGAGCTTCCAGGGGGAAACGCCTGGTAT CTTTATAGTCCTGTCGGGTTTCGCCACCTCTGACTTGAGCGTCGATTTTTGTGATGCTCGTCAGG GGGGCGGAGCCTATGGAAAAACGCCAGCAACGCGGCCTTTTTACGGTTCCTGGGCTTTTGCTGGC CTTTTGCTCACATGTTCTTTCCTGCGTTATCCCCTGATTCTGTGGATAACCGTATTACCGCCTTT GAGTGAGCTGATACCGCTCGCCGCAGCCGAACGACCGAGCGCAGCGAGTCAGTGAGCGAGGAAGC GGAAG
HPV2-Randomised Nucleotide Sequence (Segments are in a Randomisd Order) (Includes tPA Leading Sequence and HindIII Cloning Linker, Underlined) (SEQ ID NO: 71)

(60) TABLE-US-00016 ATGGATGCTATGAAGAGGGGCCTGTGCTGCGTGCTGCTGCTGTGTGGCGCCGTGTTTGTGTCCCC CAGCCAGGAAATCCACGCCCGGTTCAGAAGAGGCAGCAAGCTGGCTGCTCAGCTGGCCGACAGCG ACAGCAATGCCTGCGCCTTCCTGAAGCTGAGATACCTGCACAGCCGGATCCACGTGCTGCAGTTT CTGAACCCCTTCACCCTGCACGAGTACATGCTGGACCTGCAGCCCGAGACAACCGACCTGTACTG CTACGAGCAGGACGAGGATGAGGACGAGGTGGACCATCTGCAGGAACAGCCCCAGCAGGCCAGAA GGGATGAGCAGCACCCCTGCTACCTGATCGAGACACAGTGCTGCAGATGCGAGAGCCTGGTGGCC CAGCTGGCTGACGTGAACTCTAACGCCGCAGCCTTTCTGAAGAACAGCATCGACTGCAACGACAG CATGTGCAGCACCTTCGACGACAACGTGTCCGCCACCGAGCTCGTGAAGAGAATCCCTGCCCCTT GCCCCTGGGCCCCTGAGGAAAATGACGAGATCGACGGCGTGAACCACCAGCATCTGCCCGCTAGA AGGGCCGAGCCTCAGAGACACACCATGCTGTGCATGTGCTGCAAGTGCGAGGCCCGGATCTGCTT CCTGCTGTGCTTTTGTGTGCTGCTGTGCGTGTGCCTGCTGATCAGACCCCTGCTGCTGAGTGTGT CCACCTACTGCCAGCGGCCGCTGTGTCCTCAGGAAAAGAAACGGCACGTGGACCTGAACAAGCGG TTCCACATCTACATCTGCGAGGACGCCCAGTGCACCGTGGTGGAAGGCCAGGTGGACAGCAAGGT GTCCGAGTTCCGGTGGTACAGATACAGCGTGTACGGCACCACCCTGGGCCAGCGGAGAATCAAGA GGCCCAGATCCGAGGTGTACTGCAAGGGACAGCTGACCGAGACAGAGGTGCTGGACTTCGCCTTC ACCGACCTGACCATCGTGTACCGGGACATCCGGCTGGAATGCGCCATCATGTACAAGGCCAGAGA GATGGGCTTCCACGACCACATCGACTACTGGAAGCTGATTAGACTGGAATGTGCTATCTTCTACA AAGCCCGGATCCTGAAGTGCCTGCGGTACAGATTCAAGAAGCACTGCAAGCTGTACGTGGCCTGG GACTCCGTGTACTACTGCGGCGACGATGGCTGGTGCAAGACCAGCTCTACCTGGCACTGGACATG CCACGACGGCAAGCACAAGAACGTGTGCCAGGACAAGATCCTGGAACACTACGAGAACGACTCCA AGGACGACGAGGACGAGACAGCCTACGACAGCGGCACCGATCTGATCGACTTCATCGACGATAGC AACTGCCACCCCAACAAGCTGCTGCGGAGACTGAGCAGCGACCAGGACCAGTCTCAGAGGCCCCC CAACATGGGAGTGAAGGCCCACGGCAAGTGCATCTGGGAGAACAAGGTGTTCATCGTGCCCACCC TGTGCCCCGTGCCTCTGGATCCAACATACCCCCTGCTGAAGCTGCTGACCCCCGAAACCACAGAT CTGCACTGTTATGAGCAGCTGGGCGACTCCTCCGACGAAGAGGATACAGGCGGCCTGGATGGCTA CGAGGCCGACAAGAACGACCTGAACGCCCAGATCGAGCACTGGAAACTGATCCGGATGGAATGTG CAATTTTCTATAAGGCCAAAGAGCTGGGGATCAGCGACGAGAATGAGAACGACAGCGATACCGGC GAGGACATGGTGGATTTCATCGACAATGAGGCCGAGAAGTACGGCTGCAAGGGCACCTGGGAGGT GCACTTCGGCTTTAAGAAGCACGGCATCACCATCACCGTGCAGTACGACAACGACAAGGCCAACA CCATGGACTACACCAACTGGAAAGAGATCTACCCCCCTCCCCCCCCACGGCCTTGGGCTCCTCCA ATTCCTAAGCCCTCTCCATGGGCCCCTCAGTTCGACGGCGACATCTGCAATACCATGCACTATAC CAATTGGGTGGTGTACAGAGACAGCATCCCCCACGCCGCCTGCCACAAGTGTATCGACTTCTACA GCAGAATCAGAGAGCTGCGGCACTACAGCGACTCTGTGTACGGCGATACCCTGGAAAAGCTGACC AACACCGGCCTGTACAATCTGCTGATCCGGTGCCTGAGGCTCGTGACCAAGTATCCTCTGCTGAA ACTGCTGTCCAACTGCATCCTGTACGGCGCTGCCAATACCGGCAAGAGCCTGTTCGGCATGAGCC TGAGCAAAGTGCGGAAGCTGAGGTACTACAACTGCTCCGTGTATGGGGCCAGCCTGTGCGTGGAA TGCAAGAAAACCCTGCAGCGGAGCGAAGTGTACGACGACGAAACCGACGAGGAAAGCACCGAGAG CGACCTGGACGGCTTCATCGATAACAGCGTGATCGTGTGCCCCGCCTCCATCCCCTCCGATGAGA TCTCTACCGAGGAAGCCCCCAGACCCCCTCACTGTCCTTGGGTGCCAGTGTTCTGCAAGAAGGCC CTGACCGCCTCTGAGGTGTACAATTTTGCCTATACCGACCTGCGCGTGGTGTATAGGGACATTCT GGAACATTATGAGAATGATAGCAAGGACCTGTGCGATCACATCAACTGCCTCGTGATCTACGGCC CTCCTAACACCGGCAAGTCCTGCTTCGCCATGTCCCTGTGGAACACCGAGCCCAAGCACTGCTTC AAGAAGGGCGGCCAGCACATCGAAGTGTGGTTCGATATTGTGTACAGGGACGGCAACCCTTACGC CGTGTGCGACAAGTGCCTGAAGTTCTACTCCAAGATCAGCGAGTACCGCCACTACTGCTACTCCC TGTATGGCACAACACTGGAACAGCAGTACAACAAGCCCCTGTGCGACCTGCTGATTCGCTGCATC AACACCACCAGATACCCTCTGCTGTCCCTGCTGAACAGCTACAGCACCCCCCCTCATCGGATTCC CGCCCCATGTCCATGGGCTCCACAGAGGCCTACCCAGACCACCACCCCCGAGAATACCTCCCTGG TGGAACTGAGAGTGACCACCCCCAAGAGCACAGTCGTGATCAGGCTGCACCTGTGGCCCTACCTG CACTCCAGACTGGTGGTGTTCACCTTCCCCAACCCCTTTCACCAGGTGGTGCCCGCCCTGAATAT CTGCAAGGCCAAGGCCTGCAAAGCCATCGAGAAGAAATGGGAAGTGCACGCTGGCGGCCAAGTGA TCCTGTGTCCTGAGAGCCTGCGGCCTCTGCTGCTGTCCATTAGCGTGTACGCCCAGGTGCTGGTG CTGGTGCTGCTGCTGTGGGTGTCCATCGGCAGCAACTGTCTGGTGCTGTGCGGCCCTGCCAACAC AGGGAAGAGTTACTTCGGCATGTCTCTGATCTGCCATCAGGTGGTGCCTCCACTGGCCGCCTCTA AGGCTAAAGCCTGTCAGGCCATCGAACTGCAGCTGGCCCTGGAAGCCCTGAATGCCAGCCCCTAT GATCACATTGATTACTGGAAAGCCATCCGGCAGGAAAATGCCATCTTCTTCGCCGCCAGATGGCA TTGGACCTGTCACGATGGAAAACACAAGAATGCCATTGTGACCCTGACCTACCTGCTGCCCAGCG TGTGTATGTGCGCCTACGCTTGGGTGCTGGTGTTCGTGTACATCGTCGTGATTACCAGCCCCGCC ACCGCCGATGAGTGGACACTGCAGCAGACAAGCCTGGAAATGTGGCTGGCCGAGCCCCAGTGTGA CCATATCGATTATTGGAAACACATCCGCCTGGAATGTGCTATTATGTATAAGGCCCGGTGGCCTT ACCTGGAAAGCAGAACCGTGTTCGAGTTCCCCAATGCCTTCGCCGGCTCTGGACCTGGCGCCTCT GGAAAACCCATCCCCAATCCACTGCTGGGCCTGGACTCCACCCGGACC
HPV2-Randomised Sequence Polypeptide (Includes tPA Leading Sequence and HindIII Cloning Linker, Underlined) (SEQ ID NO: 72)

(61) TABLE-US-00017 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGSKLAAQLADSDSNACAFL KLRYLHSRIHVLQFLNPFTLHEYMLDLQPETTDLYCYEQDEDEDEVDHLQE QPQQARRDEQHPCYLIETQCCRCESLVAQLADVNSNAAAFLKNSIDCNDSM CSTFDDNVSATELVKRIPAPCPWAPEENDEIDGVNHQHLPARRAEPQRHTM LCMCCKCEARICFLLCFCVLLCVCLLIRPLLLSVSTYCQRPLCPQEKKRHV DLNKRFHIYICEDAQCTVVEGQVDSKVSEFRWYRYSVYGTTLGQRRIKRPR SEVYCKGQLTETEVLDFAFTDLTIVYRDIRLECAIMYKAREMGFHDHIDYW KLIRLECAIFYKARILKCLRYRFKKHCKLYVAWDSVYYCGDDGWCKTSSTW HWTCHDGKHKNVCQDKILEHYENDSKDDEDETAYDSGTDLIDFIDDSNCHP NKLLRRLSSDQDQSQRPPNMGVKAHGKCIWENKVFIVPTLCPVPLDPTYPL LKLLTPETTDLHCYEQLGDSSDEEDTGGLDGYEADKNDLNAQIEHWKLIRM ECAIFYKAKELGISDENENDSDTGEDMVDFIDNEAEKYGCKGTWEVHFGEK KHGTTITVQYDNDKANTMDYTNWKEIYPPPPPRPWAPPIPKPSPWAPQFDG DICNTMHYTNWVVYRDSIPHAACHKCIDFYSRIRELRHYSDSVYGDTLEKL TNTGLYNLLIRCLRLVTKYPLLKLLSNCILYGAANTGKSLFGMSLSKVRKL RYYNCSVYGASLCVECKKTLQRSEVYDDETDEESTESDLDGFIDNSVIVCP ASIPSDEISTEEAPRPPHCPWVPVFCKKALTASEVYNFAYTDLRVVYRDIL EHYENDSKDLCDHINCLVIYGPPNTGKSCFAMSLWNTEPKHCFKKGGQHIE VWFDIVYRDGNPYAVCDKCLKEYSKISEYRHYCYSLYGTTLEQQYNKPLCD LLIRCINTTRYPLLSLLNSYSTPPHRIPAPCPWAPQRPTQTTTPENTSLVE LRVTTPKSTVVIRLHLWPYLHSRLVVFTFPNPFHQVVPALNICKAKACKAI EKKWEVHAGGQVILCPESLRPLLLSISVYAQVLVLVLLLWVSIGSNCLVLC GPANTGKSYFGMSLICHQVVPPLAASKAKACQAIELQLALEALNASPYDHI DYWKAIRQENAIFFAARWHWTCHDGKHKNAIVTLTYLLPSVCMCAYAWVLV FVYIVVITSPATADEWTLQQTSLEMWLAEPQCDHIDYWKHIRLECAIMYKA RWPYLESRTVFEFPNAFAGSGPGASGKPIPNPLLGLDSTRT**
HPV53del Nucleotide Sequence (Segments from HPV53 have been Removed) (Includes tPA Leading Sequence and HindIII Cloning Linker, Underlined) (SEQ ID NO: 73)

(62) TABLE-US-00018 ATGGATGCTATGAAGCGAGGACTGTGCTGCGTGCTGCTGCTGTGTGGCGCT GTGTTTGTGTCCCCTAGCCAAGAGATCCACGCCAGATTCAGACGGGGCAGC AAACTGGCCGACGAGGATGAGACAGCCTACGACTCTGGCACCGACCTGATC GACTTCATCGACGACAGCGACGAGAACGAGAATGACAGCGACACCGGCGAG GACATGGTGGATTTCATCGACAATGCCCAGCTGGCCGACTCCGACTCTAAT GCCTGTGCCTTTCTGAAGGCTCAGCTGGCTGACGTGAACAGCAATGCCGCC GCTTTCCTGAAGAACTGCATCCTGCTGTACGGCGCTGCCAACACAGGCAAG AGCCTGTTTGGCATGAGCCTGAACTGCCTGGTGCTGTGCGGACCTGCCAAT ACCGGCAAAAGCTACTTCGGCATGTCCCTGTGGCCTTACCTGCACAGCAGA CTGGTGGTGTTTACATTCCCCAATCCTTTCTGGCCCTACCTGGAAAGCCGG ATCACCGTGTTCGAGTTCCCCAACGCCTTCAACGTGTGCCAGGACAAGATC CTGGAACACTATGAGAACGACAGCAAGGACATCCTTGAGCACTACGAAAAC GACTCCAAGGACCTGTGCGACCACATCTGCGATCACATCGACTACTGGAAG CACATCCGGCTGGAATGCGCCATCATGTACAAGGCCCGGATCAGACTGGAA TGTGCTATTATGTATAAGGCTCGCGAGATGGGCTTCCACCAGTTCGACGGC GACATCTGCAACACCATGCACTACACCAACTGGATCTATATCTGCGAGGAC GCCCAGTGCACCGTGGTGGAAGGACAGGTGGACAAGAAATGGGAAGTGCAC GCTGGCGGCCAAGTGATTCTGTGTCCTGAGAGCGGCCAGCGGAGAATCAAG AGGCCCAGATCCGAGAACTGTCACCCCAACAAGCTGCTGATCCTGAAGTGC CTGCGGTACAGATTCAAGAAGCACTGCAAGCTGAGCAGCACCTGGCACTGG ACATGCCACGATGGCAAGCACAAGTGGCATTGGACCTGTCACGACGGGAAA CACAAGAACGCCATCGTGACCCTGACCTACTACGAGGCCGACAAGAACGAC CTGAACGCCCAGATTGAGCACTGGAAACTGATCCGGATGGAATGTGCAATC TTCTATAAGGCCAAAGAGCTGGGGATCAGCATCTGCCACCAGGTGGTGCCT CCACTGGCTGCCTCTAAAGCCAAAGCCTGTCAGGCCATCGAACTGCAGCTG GCCCTGGAAGCCCTGAACGCTAGCCCTTACGATGAGTGGACCCTGCAGCAG ACCAGCCTGGAAATGTGGCTGGCCGAGCCTCAGTTTAAGAAGCACGGCATC ACCATCACCGTGCAGTACGACAACGACAAGGCCAATACCATGGATTACACG AATTGGAAAGAAATCTACGTGATCGTGTGCCCCGCCAGCATTCCCTCCGAT GAGATCTCTACCGAGGAAGCCGACCACATTGATTATTGGAAGGCCATCCGG CAAGAGAATGCCATCTTCTTCGCCGCCAGACATCAGGTGGTCCCCGCTCTG AATATCTGCAAGGCCAAGGCCTGCAAAGCCATCGAGTGGAACACCGAGCCT AAGCACTGCTTCAAGAAAGGCGGCCAGCACATCGAAGTTTGGTTCGACTAC GTGGCCTGGGACAGCGTGTACTACTGCGGAGATGATGGCTGGTGCAAGACC GAGGCCGAGAAGTACGGCTGTAAAGGCACCTGGGAAGTCCACTTCGGCAAC AGCATCGACTGCAACGATAGCATGTGCAGCACCTTCGACGACAACGTGTCC GCCACAGAGCTGGTCAAGGACCATATAGACTATTGGAAGCTGATCAGGCTT GAGTGCGCCATTTTCTACAAGGCCAGACGGCGGCTGTCCAGCGACCAGGAT CAATCTCAGCTCGTGACCAAGTATCCCCTGCTGAAGCTGCTGTCTACCCAG ACCACCACACCTGAGAACACAAGCCTGGTGGAACTGAGAGTGACCACACCT AAGAGCACCGTCGTGATTCGGCTGCACCTGACCACAAGATACCCTCTGCTG AGCCTGCTGAACAGCTACAGCACCCCTCCACACAGGATCCCCGCTCCATGT CCTTGGGCTCCTCAGAGGCCTCCTATTCCTAAGCCTTCTCCATGGGCTCCT AGAATCCCCGCACCTTGTCCATGGGCACCACCAAGACCTCCACATTGCCCT TGGGTGCCCTGTTTCCTGCTGTGCTTTTGCGTGCTCCTGTGCGTGTGCCTG CTGATCAGACCTCTGCTGCTGAGCGTGTCCACCTACCTTAGACCACTGCTC CTGTCCATCTCCGTGTACGCACAGGTGCTGGTGCTGGTCCTGCTTCTGTGG GTGTCCATCGGAAGCCTGCTGCCTAGCGTGTGCATGTGTGCCTATGCTTGG GTGCTCGTGTTCGTGTACATCGTGGTCATCACAAGCCCCGCCACAGCCATC GTGTACAGAGATGGCAATCCCTACGCCGTGTGCGACAAGTGCCTGAAGTTC TACAGCAAGATCAGCGAGTACCGGCACTACTGCTACAGCCTGTACGGCACC ACACTGGAACAGCAGTACAACAAGCCCCTGTGCGATCTGCTGATTCGGTGC ATCAACGTGGTGTACCGGGACAGCATTCCTCACGCCGCCTGCCACAAGTGC ATCGACTTCTACTCCAGAATCAGAGAGCTGCGGCACTACAGCGACTCTGTG TACGGCGACACCCTGGAAAAGCTGACCAACACCGGCCTGTACAACCTGCTG ATTAGATGCCTGCGGGTGTACTGCAAGGGACAGCTGACAGAGACAGAGGTG CTGGACTTCGCCTTCACCGATCTGACAATCGTGTATCGGGATAGCAAGGTG TCCGAGTTCCGGTGGTACAGATATAGCGTGTACGGAACAACCCTGTGCGTC GAGTGCAAGAAAACCCTGCAGAGAAGCGAGGTGTACGACTGCCAGAGGCCA CTGTGCCCTCAAGAGAAGAAACGGCACGTGGACCTGAACAAGCGGTTTCAC ACCCTGCACGAGTACATGCTGGACCTGCAGCCTGAGACAACCGACCTGTAC TGCTACGAGCAGCCCGAAACCACAGATCTGCACTGTTATGAGCAGCTGGGC GACAGCAGCGACGAAGAGGATACAGGCGGACTGGACGGCGAGGAAAACGAC GAAATTGACGGCGTGAACCACCAGCATCTCCCCGCCAGAAGGGCTGAACCT CAGAGACACACCATGCTGTGTATGTGCTGCAAGTGCGAGGCCAGAATCGCC TGATGA
HPV53del Polypeptide Sequence (Includes tPA Leading Sequence and HindIII Cloning Linker, Underlined) (SEQ ID NO:74)

(63) TABLE-US-00019 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGSKLADEDETAYDSGTDLI DFIDDSDENENDSDTGEDMVDFIDNAQLADSDSNACAFLKAQLADVNSNAA AFLKNCILLYGAANTGKSLFGMSLNCLVLCGPANTGKSYFGMSLWPYLHSR LVVFTFPNPFWPYLESRITVFEFPNAFNVCQDKILEHYENDSKDILEHYEN DSKDLCDHICDHIDYWKHIRLECAIMYKARIRLECAIMYKAREMGEHQEDG DICNTMHYTNWIYICEDAQCTVVEGQVDKKWEVHAGGQVILCPESGQRRIK RPRSENCHPNKLLILKCLRYRFKKHCKLSSTWHWTCHDGKHKWHWTCHDGK HKNAIVILTYYEADKNDLNAQIEHWKLIRMECAIFYKAKELGISICHQVVP PLAASKAKACQAIELQLALEALNASPYDEWTLQQTSLEMWLAEPQFKKHGI TITVQYDNDKANTMDYTNWKEIYVIVCPASIPSDEISTEEADHIDYWKAIR QENAIFFAARHQVVPALNICKAKACKAIEWNTEPKHCFKKGGQHIEVWFDY VAWDSVYYCGDDGWCKTEAEKYGCKGTWEVHFGNSIDCNDSMCSTFDDNVS ATELVKDHIDYWKLIRLECAIFYKARRRLSSDQDQSQLVTKYPLLKLLSTQ TTTPENTSLVELRVTTPKSTVVIRLHLTTRYPLLSLLNSYSTPPHRIPAPC PWAPQRPPIPKPSPWAPRIPAPCPWAPPRPPHCPWVPCFLLCFCVLLCVCL LIRPLLLSVSTYLRPLLLSISVYAQVLVLVLLLWVSIGSLLPSVCMCAYAW VLVFVYIVVITSPATAIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGT TLEQQYNKPLCDLLIRCINVVYRDSIPHAACHKCIDFYSRIRELRHYSDSV YGDTLEKLTNTGLYNLLIRCLRVYCKGQLTETEVLDFAFTDLTIVYRDSKV SEFRWYRYSVYGTTLCVECKKTLQRSEVYDCQRPLCPQEKKRHVDLNKRFH TLHEYMLDLQPETTDLYCYEQPETTDLHCYEQLGDSSDEEDTGGLDGEEND EIDGVNHQHLPARRAEPQRHTMLCMCCKCEARIA**
HPV3-Linkers Nucleotide Sequence (Includes tPA Leading Sequence and HindIII Cloning Linker, Underlined) (SEQ ID NO: 75)

(64) TABLE-US-00020 ATGGATGCTATGAAGAGGGGCCTGTGCTGCGTGCTGCTGCTGTGTGGCGCC GTGTTTGTGTCCCCCAGCCAGGAAATCCACGCCCGGTTCAGAAGAGGCAGC AAGCTGGCCGACGAGGACGAGACAGCCTACGACAGCGGCACCGACCTGATC GACTTCATCGACGATAGCGCCGCTGCCGACGAGAATGAGAACGACAGCGAT ACCGGCGAGGACATGGTGGATTTCATCGACAACGCTGCCGCCGACGAAACC GACGAAGAGAGCACCGAGAGCGACCTGGACGGCTTTATCGACAACAGCGCA GCCGCCCAGCTGGCTGACAGCGACTCTAATGCCTGCGCCTTCCTGAAGGCC GCTGCTCAGCTGGCAGACGTGAACAGCAATGCCGCCGCTTTTCTGAAGGCT GCCGCCAACTGCATCCTGCTGTACGGCGCTGCCAACACCGGCAAGAGCCTG TTCGGCATGTCTCTGGCCGCAGCCAACTGCCTGGTGCTGTGCGGACCTGCC AATACTGGCAAAAGCTACTTCGGCATGAGCCTGGCAGCCGCCAATTGTCTC GTGATCTACGGCCCTCCTAATACCGGCAAGTCCTGCTTTGCCATGAGTCTG GCCGCTGCCTGGCCCTACCTGCACTCTAGACTGGTGGTGTTCACCTTCCCC AACCCCTTCGCTGCCGCTTGGCCTTACCTGGAAAGCCGGATCACCGTGTTC GAGTTCCCCAATGCCTTCGCCGCAGCCCTGAGATACCTGCACAGCAGAATC CACGTGCTGCAGTTTCTGAACCCCTTTGCCGCCGCAAACGTGTGCCAGGAC AAGATCCTGGAACACTACGAGAACGACTCCAAGGATGCCGCTGCCATTCTG GAACATTATGAGAATGATAGCAAGGACCTGTGCGACCACATTGCTGCCGCC TGCGATCACATCGACTACTGGAAGCACATCCGGCTGGAATGCGCCATCATG TACAAGGCCAGAGCCGCCGCTATCAGACTGGAATGTGCTATTATGTATAAG GCTCGCGAGATGGGCTTCCACGCTGCTGCCCAGTTCGACGGCGACATCTGC AACACCATGCACTACACCAACTGGGCTGCCGCTATCTACATCTGCGAGGAC GCCCAGTGCACCGTGGTGGAAGGACAGGTGGACGCCGCTGCTAAGAAATGG GAGGTGCACGCTGGCGGCCAAGTGATCCTGTGTCCAGAGTCTGCTGCCGCA GGCCAGCGGAGAATCAAGAGGCCTAGAAGCGAGGCAGCCGCTAACTGCCAC CCCAACAAACTGCTGGCTGCTGCCATCCTGAAGTGCCTGCGGTACAGATTC AAGAAGCACTGCAAACTGGCTGCAGCTAGCAGCACCTGGCACTGGACCTGT CACGACGGCAAGCACAAAGCCGCCGCATGGCATTGGACATGCCACGATGGA AAACACAAGAACGCCATCGTGACCCTGACCTATGCAGCCGCCTACGAGGCC GACAAGAACGACCTGAACGCCCAGATCGAGCACTGGAAGCTGATCAGGATG GAATGTGCAATCTTCTATAAGGCCAAAGAGCTGGGCATCAGCGCTGCCGCA ATCTGCCACCAGGTGGTGCCTCCACTGGCCGCCTCTAAAGCCAAAGCCTGC CAGGCCATCGAACTGCAGCTGGCCCTGGAAGCCCTGAATGCCAGCCCTTAT GCCGCAGCCGATGAGTGGACCCTGCAGCAGACCAGCCTGGAAATGTGGCTG GCCGAACCTCAGGCCGCAGCTTTTAAGAAGCACGGCATCACCATCACCGTG CAGTACGACAACGACAAGGCCAATACCATGGATTACACCAATTGGAAAGAG ATCTACGCCGCAGCTGTGATCGTGTGCCCCGCCAGCATCCCTAGCGACGAG ATCAGCACAGAGGAAGCAGCCGCCGACCACATCGATTATTGGAAAGCCATC AGACAGGAAAACGCCATCTTCTTCGCCGCTAGAGCCGCTGCCCACCAGGTG GTGCCAGCCCTGAATATCTGCAAGGCCAAGGCCTGTAAAGCCATCGAAGCC GCTGCTTGGAACACCGAGCCCAAGCACTGCTTCAAGAAGGGCGGCCAGCAC ATCGAAGTGTGGTTCGACGCTGCAGCCTACGTGGCCTGGGACAGCGTGTAC TACTGTGGCGACGACGGCTGGTGCAAGACCGCCGCTGCAGAGGCCGAGAAG TATGGCTGCAAGGGCACCTGGGAAGTGCATTTCGGCGCAGCTGCCAACTCC ATCGACTGCAACGACAGCATGTGCAGCACCTTCGACGACAACGTGTCCGCC ACCGAGCTCGTGAAAGCTGCCGCTGACCATATTGATTACTGGAAACTGATT CGCCTGGAATGCGCTATTTTCTACAAAGCCAGGGCCGCAGCACGGCGGCTG TCCTCAGATCAGGATCAGAGCCAGGCTGCTGCACTCGTGACCAAGTACCCC CTGCTGAAGCTGCTGAGCGCCGCAGCAAGACCCCCCAACATGGGAGTGAAG GCCCACGGCAAGTGCATCTGGGAGAACAAGGTGTTCATCGTGCCCACCCTG TGCCCCGTGCCTCTGGATCCAACATATCCTCTGCTGAAACTGCTGACCGCT GCCGCCACCCAGACCACCACACCTGAGAATACCTCCCTGGTGGAACTGAGA GTGACCACCCCCAAGAGCACAGTCGTGATCAGGCTGCACCTGGCTGCCGCA ACCACCAGATACCCTCTGCTGTCCCTGCTGAACAGCTACAGCACCCCCCCT CATCGGATCCCTGCCCCTTGTCCTTGGGCTCCTCAGAGGCCTGCCGCTGCA CCTATCCCTAAGCCTTCTCCATGGGCCCCTGCCGCAGCTAGAATCCCAGCT CCATGTCCATGGGCACCAGCTGCTGCTCCCAGACCTCCTCATTGCCCTTGG GTGCCAGCAGCCGCTCCTCCACCTCCTCCTAGACCTTGGGCCCCAGCCGCC GCTTGTTTCCTGCTGTGCTTCTGTGTGCTGCTGTGCGTGTGCCTGCTGATC AGACCCCTGCTGCTGAGTGTGTCCACCTACGCAGCTGCTCTGCGGCCACTG CTGCTGTCCATCTCTGTGTACGCACAGGTGCTGGTGCTGGTGCTGCTGCTG TGGGTGTCCATCGGATCTGCCGCAGCACTGCTGCCCTCCGTGTGCATGTGT GCCTATGCCTGGGTGCTGGTGTTCGTGTACATCGTCGTGATTACCAGCCCC GCCACCGCAGCCGCAATCGTGTACAGGGACGGCAACCCTTACGCCGTGTGC GACAAGTGCCTGAAGTTCTACAGCAAGATCAGCGAGTACCGCCACTACTGC TACAGCCTGTACGGCACCACCCTGGAACAGCAGTACAACAAGCCCCTGTGC GATCTGCTGATCCGGTGCATCAACGCAGCCGCTGTGGTGTACAGAGACAGC ATCCCACACGCCGCCTGCCACAAGTGTATCGACTTCTACTCCCGGATCAGA GAGCTGAGACACTACTCCGACTCCGTGTACGGCGATACCCTGGAAAAGCTG ACCAATACCGGCCTGTACAACCTGCTGATTAGATGCCTGCGGGCAGCCGCA GTGTTCTGCAAGAAAGCCCTGACCGCCAGCGAGGTGTACAACTTCGCCTAC ACCGATCTGCGGGTGGTGTACCGGGATGCTGCTGCCTCCAAAGTGCGGAAG CTGCGGTACTACAACTGCTCTGTGTATGGCGCCTCCCTGGCAGCTGCCGTG TATTGCAAGGGACAGCTGACCGAGACAGAGGTGCTGGATTTCGCCTTCACA GACCTGACCATCGTGTATAGAGATGCAGCTGCTAGCAAGGTGTCCGAGTTC CGGTGGTACAGATATAGCGTGTACGGAACAACACTGGCAGCAGCTTGCGTG GAATGCAAGAAAACACTGCAGCGGAGCGAAGTGTACGATGCTGCAGCTTGC CAGAGGCCGCTGTGTCCTCAGGAAAAGAAAAGACACGTGGACCTGAACAAG CGGTTCCACGCAGCAGCTACCCTGCACGAGTACATGCTGGACCTGCAGCCC GAGACAACCGACCTGTACTGCTACGAGCAGGCAGCTGCACCCGAAACCACA GATCTGCACTGTTATGAGCAGCTGGGAGACAGCTCCGATGAAGAGGACACC GGCGGACTGGATGCTGCCGCTGGGGATGAGGACGAGGATGAGGTGGACCAT CTGCAGGAACAGCCCCAGCAGGCCAGAAGGGATGAGCAGCACCCCTGCTAT CTGATCGAGACACAGTGCTGCAGATGCGAGAGCCTGGTGGCCGCTGCTGAG GAAAACGACGAGATCGACGGCGTGAACCACCAGCATCTGCCCGCTAGAAGG GCCGAGCCTCAGAGACACACCATGCTGTGTATGTGTTGCAAGTGCGAGGCC CGGATCGCCGGATCTGGACCTGGCGCTAGCGGAAAGCCCATCCCCAATCCA CTGCTGGGCCTGGACTCCACCCGGACCTGATAA
HPV3-Linkers Polypeptide Sequence (Includes tPA Leading Sequence and HindIII Cloning Linker, Underlined) (SEQ ID NO: 76)

(65) TABLE-US-00021 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGSKLADEDETAYDSGTDLI DFIDDSAAADENENDSDTGEDMVDFIDNAAADETDEESTESDLDGFIDNSA AAQLADSDSNACAFLKAAAQLADVNSNAAAFLKAAANCILLYGAANTGKSL FGMSLAAANCLVLCGPANTGKSYFGMSLAAANCLVIYGPPNTGKSCFAMSL AAAWPYLHSRLVVFTFPNPFAAAWPYLESRITVFEFPNAFAAALRYLHSRI HVLQFLNPFAAANVCQDKILEHYENDSKDAAAILEHYENDSKDLCDHIAAA CDHIDYWKHIRLECAIMYKARAAAIRLECAIMYKAREMGFHAAAQFDGDIC NTMHYTNWAAAIYICEDAQCTVVEGQVDAAAKKWEVHAGGQVILCPESAAA GQRRIKRPRSEAAANCHPNKLLAAAILKCLRYRFKKHCKLAAASSTWHWTC HDGKHKAAAWHWTCHDGKHKNAIVTLTYAAAYEADKNDLNAQIEHWKLIRM ECAIFYKAKELGISAAAICHQVVPPLAASKAKACQAIELQLALEALNASPY AAADEWTLQQTSLEMWLAEPQAAAFKKHGITITVQYDNDKANTMDYTNWKE IYAAAVIVCPASIPSDEISTEEAAADHIDYWKAIRQENAIFFAARAAAHQV VPALNICKAKACKAIEAAAWNTEPKHCFKKGGQHIEVWFDAAAYVAWDSVY YCGDDGWCKTAAAEAEKYGCKGTWEVHFGAAANSIDCNDSMCSTFDDNVSA TELVKAAADHIDYWKLIRLECAIFYKARAAARRLSSDQDQSQAAALVTKYP LLKLLSAAARPPNMGVKAHGKCIWENKVFIVPTLCPVPLDPTYPLLKLLTA AATQTTTPENTSLVELRVTTPKSTVVIRLHLAAATTRYPLLSLLNSYSTPP HRIPAPCPWAPQRPAAAPIPKPSPWAPAAARIPAPCPWAPAAAPRPPHCPW VPAAAPPPPPRPWAPAAACFLLCFCVLLCVCLLIRPLLLSVSTYAAALRPL LLSISVYAQVLVLVLLLWVSIGSAAALLPSVCMCAYAWVLVFVYIVVITSP ATAAAIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLC DLLIRCINAAAVVYRDSIPHAACHKCIDFYSRIRELRHYSDSVYGDTLEKL TNTGLYNLLIRCLRAAAVFCKKALTASEVYNFAYTDLRVVYRDAAASKVRK LRYYNCSVYGASLAAAVYCKGQLTETEVLDFAFTDLTIVYRDAAASKVSEF RWYRYSVYGTTLAAACVECKKTLQRSEVYDAAACQRPLCPQEKKRHVDLNK RFHAAATLHEYMLDLQPETTDLYCYEQAAAPETTDLHCYEQLGDSSDEEDT GGLDAAAGDEDEDEVDHLQEQPQQARRDEQHPCYLIETQCCRCESLVAAAE ENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCEARIAGSGPGASGKPIPNP LLGLDSTRT**

(66) TABLE-US-00022 TABLE 9 Summary of Fragment Variants with SEQ ID NOs. (FIGS. 2-4) SEQ  ID NO: Protein Fragment 160 conserved region 1 DEDENASDTGXDLVDFIDNS 161 conserved region 1 DENENDSDTGEDLVDFIVND 162 conserved region 1 DEDENATDTGSDMVDFIDTQ 163 conserved region 1 DENEDSSDTGEDMVDFIDNC 164 conserved region 1 DEDENAYDSGTDLIDFIDDS 3 conserved region 1 DETDEESTESDLDGFIDNS 165 conserved region 1 DEDETADDSGTDLIEFIDDS 166 conserved region 1 DEDEXAXDSGTDLIXFIDDS 167 conserved region 1 DEDENAYDSGTDLIDFIDDS 168 conserved region 1 DEDETADDSGTDLIEFIDDS 169 conserved region 1 DENENXSDTGEDMVDFIDN 170 conserved region 1 DENEDSSDTGEDMVDFIDN 171 conserved region 1 DENENDSDTGEDLVDFIVN 172 conserved region 1 DEDENATDTGSDMVDFIDT 3 conserved region 1 DETDEESTESDLDGFIDNS 5 conserved region 2 AQLADVNSNAAAFLK 173 conserved region 2 AQLADTNSNASAFLK 174 conserved region 2 ALLADSNSNAAAFLK 175 conserved region 2 AQLADSDSNACAFLK 5 conserved region 2 AQLADVNSNAAAFLK 176 conserved region 2 AQLADVDSNAQAFLK 177 conserved region 2 AQLADVNSNAAAFLR 4 conserved region 2 AQLADSDSNACAFLK 4 conserved region 2 AQLADSDSNACAFLK 178 conserved region 2 AQLADVDSNAQAFLK 5 conserved region 2 AQLADVNSNAAAFLK 5 conserved region 2 AQLADVNSNAAAFLK 179 conserved region 2 AQLADVNSNAAAFLR 180 conserved region 2 ALLADSNSNAAAFLK 181 conserved region 2 AQLADTNSNASAFLK 182 conserved region 3 NCLXLYGPANTGKSYFGMSL 6 conserved region 3 NCILLYGAANTGKSLFGMSL 183 conserved region 3 NCLVFCGPANTGKSYFGMSF 184 conserved region 3 NCILIHGAPNTGKSYFGMSL 185 conserved region 3 NCLVLYGPANTGKSYFGMSL 8 conserved region 3 NCLVIYGPPNTGKSCFAMSL 186 conserved region 3 SCMLLCGPANTGKSYFGMSL 187 conserved region 3 NCILJYGAANTGKSLFGMSL 6 conserved region 3 NCILLYGAANTGKSLFGMSL 188 conserved region 3 NCILIHGAPNTGKSYFGMSL 7 conserved region 3 NCLVLCGPANTGKSYFGMSL 189 conserved region 3 NCLVFCGPANTGKSYFGMSF 190 conserved region 3 NCLVLYGPANTGKSYFGMSL 191 conserved region 3 SCMLLCGPANTGKSYFGMSL 8 conserved region 3 NCLVIYGPPNTGKSCFAMSL 192 conserved region 4 DEDENASDTGXDLVDFIDNS 193 conserved region 4 DENENDSDTGEDLVDFIVND 194 conserved region 4 DEDENATDTGSDMVDFIDTQ 195 conserved region 4 DENEDSSDTGEDMVDFIDNC 196 conserved region 4 DEDENAYDSGTDLIDFIDDS 3 conserved region 4 DETDEESTESDLDGFIDNS 197 conserved region 4 DEDETADDSGTDLIEFIDDS 9 conserved region 4 WPYLHSRLVVFTFPNPF 198 conserved region 4 WPYLHNRLVVFTFPNEF 9 conserved region 4 WPYLHSRLVVFTFPNPF 199 conserved region 4 WPYLHSRLVVFHFKNPF 200 conserved region 4 WPYLESRJTVFEFPNAF 10 conserved region 4 WPYLESRITVFEFPNAF 201 conserved region 4 WPYLHSRLTVFEFNNPF 11 conserved region 4 LRYLHSRIHVLQFLNPF 202 conserved region 1 DHIDYWKHMRLECAIYYKAR 202 conserved region 1 DHIDYWKHMRLECAIYYKAR 203 conserved region 1 SQIQYWQLIRWENAIFFAAR 204 conserved region 1 DHIDYWKHIRLECVLMYKAR 205 conserved region 1 AQIEHWKLTRMECVLFYKAK 206 conserved region 1 DHIDYWKAVRQENVIYYKAR 207 conserved region 1 SQIEHWKLIRMECAIMYTAR 35 conserved region 1 DHIDYWKLIRLECAIFYKAR 208 conserved region 1 PIPPPCPWAPKK 209 conserved region 1 TPPHRPIPKPSPWAPKKE 210 conserved region 1 TPPHRIPAPCPWAPQRP 211 conserved region 1 TPPHRIPKPAPWAPVKV 212 conserved region 1 PRPPHCPWVPKTE 213 conserved region 1 PPPPPRPWAPTKP 41 conserved region 1 PIPKPSPWAP 41 conserved region 1 PIPKPSPWAP 214 conserved region 1 RIPKPAPWAP 42 conserved region 1 RIPAPCPWAP 43 conserved region 1 PRPPHCPWVP 44 conserved region 1 PPPPPRPWAP