CANNABINOIDS-CONTAINING BEVERAGES

Abstract

Cannabinoids-containing aqueous beverage comprising cannabinoids and phospholipids.

Claims

1. Cannabinoids-containing aqueous beverage comprising cannabinoids and phospholipids.

2. The cannabinoids-containing beverage of claim 1, comprising: from 1 to 20 mg/100 ml cannabinoids; and from 1 to 20 mg/100 ml phospholipids.

3. A method for the preparation of cannabinoids-containing beverages of claim 1, comprising a step of incorporating a pre-prepared cannabinoids/phospholipids mixture into an aqueous beverage.

4. A method for the preparation of cannabinoids-containing beverages according to claim 3, comprising: providing a beverage component in the form of a well-mixed mixture of cannabinoids and phospholipids; and gradually combining a beverage and the cannabinoids/phospholipids mixture under mixing, and optionally homogenizing the so-formed cannabinoids-containing beverage.

5. A method according to claim 3, wherein incorporation of the cannabinoids/phospholipids mixture into the beverage is in the form of a liquid concentrate comprising said cannabinoids/phospholipids mixture and a liquid carrier corresponding to the beverage to be produced.

6. A method according to claim 5, comprising dilution of the concentrate by addition with mixing of the rest of the beverage volume, following which the resulting composition is optionally homogenized to afford the finished beverage.

7. A method according to claim 5, comprising addition of the concentrate into the rest of the beverage volume with mixing, following which the resulting composition is optionally homogenized to afford the finished beverage.

8. A method according to claim 3, comprising homogenizing the concentrate, homogenizing the composition formed during dilution/addition, and/or homogenizing after addition/dilution is completed.

9. A method according to claim 8, wherein homogenization is achieved by one or more of the following: an overhead stirrer, ultrasonic homogenizer and/or high-pressure homogenizer.

10. (canceled)

11. The method of claim 3, wherein the cannabinoids/phospholipids mixture is a liquid mixture.

12. Cannabinoids-containing liquid concentrate for beverage manufacture, comprising cannabinoids/phospholipids mixture in a liquid carrier consisting of said beverage.

13. The concentrate of claim 12, wherein the concentration of the cannabinoids/phospholipids mixture in the concentrate is not less than 50% w/v.

14. Beverage component which is a well-mixed, pre-prepared mixture consisting one or more cannabinoid(s) one or more phospholipid(s) and optionally antioxidant(s), wherein said mixture is a liquid.

Description

EXAMPLES

[0021]

TABLE-US-00001 Materials Abbreviation Manufacturer Phospholipon 90G PL 90G Lipoid.sup.a Lipoid S100 Lipoid.sup.a Sunlipon 90 SL 90 Perimondo.sup.b Propylene glycol PG Tamar.sup.c Sodium benzoate Sigma Aldrich.sup.c Cannabidiol, CBD.sup.1 Aifame.sup.d Obtained by extraction from plants, purity 93.7% Cannabidiol, synthetic CBD.sup.2 STI Pharmaceuticals .sup.e Tetrahydrocannabinol THC BOL Pharma.sup.c .sup.aGermany .sup.bUSA .sup.cIsrael .sup.dSwitzerland .sup.e UK

TABLE-US-00002 Beverages Ingredients (detailed by Beverage Brand Manufacturer the manufacturer) Neviot Mineral Neviot Galilee Natural mineral water water Teva, Israel Mey Eden Eden Springs, Natural mineral water - Mineral water Israel Tapuzina Jafora Tabori, Water, sugar, orange juice, orange Israel citric acid, guar gum, acacia gum, kayara gum, sodium citrate, potassium citrate, ascorbic acid, flavoring and coloring agents. Mirinda Pepsico, Israel Water, sugar, carbon dioxide, (orange acacia gum, glycerol ester of flavored) gum rosin, sodium benzoate, vitamin C, citric acid, flavor- ing and coloring agents. Prigat Prigat, Israel Water, grapefruit juice, (Grapefruit fructose, sugar, citric acid, soft drink) potassium citrate, pectin, acacia gum, vitamin C, and flavoring agents. Topuzina Jafora Tabori, Water, apple juice, maleic acid, (Transparent Israel potassium citrate, ascorbic acid apple soft and flavoring agents. drink) Fanta Coca- Cola Water, sugar, fructose, carbon company, Israel dioxide, citric acid, sodium citrate, beta carotene, acacia gum, sucrose acetate isobutyrate, ascorbic acid, and flavoring agents. Red Bull Red Bull, Water, sugar, glucose, citric energy drink Austria acid, carbon dioxide, taurine, sodium bicarbonate, magnesium carbonate, caffeine, Vitamins: niacin, pantothenic acid (B5), pyridoxine, riboflavin, cobalamin (B12), flavoring agents, and riboflavin coloring agent Gatorade Pepsico, Italy Water, sugar, maltodextrin, Orange citric acid, sodium citrate, sodium chloride, potassium phosphate, glycol ester of wood rosin, acacia gum, ascorbic acid, flavoring and coloring agents, magnesium oxide, acesulfame potassium, sucralose, beta carotene, tocopheryl acetate Gatorade Pepsico, Italy Water, sugar, maltodextrin, citric Blue acid, sodium citrate, sodium chloride, potassium phosphate, glycol ester of wood rosin, acacia gum, ascorbic acid, flavoring and coloring agents, magnesium oxide, acesulfame potassium, sucralose, brilliant blue fcf, tocopheryl acetate Gatorade Pepsico, Italy Water, sugar, maltodextrin, citric Red orange acid, sodium citrate, sodium chloride, potassium phosphate, glycol ester of wood rosin, acacia gum, ascorbic acid, flavoring and coloring agents, magnesium oxide, acesulfame potassium, sucralose, beta carotene, tocopheryl acetate Bavaria 0.0% Bavaria, The Natural mineral water, barley Alcohol Malt Netherlands malt, maltose and hops. Drink Nestle Bottled Nestle, Jordan Natural mineral water Drinking Water Stella Artois Stella Artois, Water, barely malt, corn, carbon 5% Alcohol Belgium dioxide. Starbucks Pepsico, USA Coffee, water, reduced fat milk, chilled sugar, maltodextrin, pectin, coffee drink ascorbic acid.

Example 1

[0022]

TABLE-US-00003 CBD.sup.1 10 mg PL 90G 10 mg Mineral Water 80 ml

[0023] Preparation Method:

[0024] The phospholipid is kneaded well, and then mixed with CBD for about one hour with intermittent mixing. The process is carried out at room temperature or at the usual ambient temperature. Then, the Mineral Water is added gradually through mixing. The obtained dispersion is further homogenized in ultrasound or high-pressure food homogenizer.

Example 2

[0025]

TABLE-US-00004 CBD.sup.1 10 mg PL 90G 10 mg Mirinda 80 ml

Preparation Method:

[0026] PL90G is well kneaded and then mixed with CBD for 60 minutes with intermittent mixing. The process is carried out at room temperature or at the usual ambient temperature. Then the Mirinda is added gradually through mixing. The obtained drink is homogeneous. If wanted, the product can be further homogenized using an ultrasound or high-pressure food apparatus.

Example 3

[0027]

TABLE-US-00005 % w/v CBD.sup.1 10 mg 0.0125 g PL 90G 5 mg 0.00625 g Mineral Water 80 ml 100 ml

Preparation Method:

[0028] Phospholipid is kneaded well, then mixed with CBD for about an hour with intermittent mixing. The process can be carried out at room temperature or at the usual ambient temperature. Then the Mineral Water is added gradually through mixing. The obtained dispersion is further homogenized using a food homogenizer.

Example 4

[0029]

TABLE-US-00006 % w/v CBD.sup.1 10 mg 0.0125 g PL 90G 5 mg 0.00625 g Mirinda 80 ml 100 ml

Preparation Method:

[0030] PL was kneaded well then mixed with CBD for 1 hour with intermittent mixing. Then the Mirinda was added gradually through mixing. The process is carried out at room temperature or at the usual ambient temperature. The obtained drink is homogeneous. If wanted, it can be further homogenized using a food apparatus.

Example 5

[0031]

TABLE-US-00007 % w/v CBD.sup.1 10 mg 0.0125 g THC 2 mg 0.0025 g Lipoid S100 7 mg 0.00875 g Mirinda 80 ml 100 ml

Preparation Method for 100 ml Drink:

[0032] PL is kneaded well then mixed with CBD and THC for 40 minutes with intermittent mixing. Then 20 ml Mirinda is added gradually through mixing to make a concentrate. The obtained concentrate dispersion is diluted by slow and gradual addition mixing with the remaining volume of the beverage. The composition may further be homogenized using various food homogenizers.

[0033] Phospholipids and cannabinoids are thermosensitive. No need to heat or use of heat to prepare the cannabinoid mixture component.

Example 6

[0034]

TABLE-US-00008 CBD.sup.1 10 mg PL 90G 10 mg Mineral Water 80 ml

[0035] Preparation Method:

[0036] Phospholipid was worked well and then mixed with CBD with intermittent mixing. Then, ten ml Mineral Water were added gradually through mixing in a mortar and pestle. The obtained liquid was transferred into a glass vessel to which the remaining mineral water volume was added gradually through mixing using an overhead stirrer at 700 rpm (Heidolph RZR 2000 Digital, Heidolph Instruments, Germany). The obtained composition was further homogenized for 10 cycles in a high-pressure homogenizer (M-110P Microfluidizer®: A “Plug and Play” Electric Benchtop Laboratory Homogenizer, Microfluidics, USA).

Example 7

[0037]

TABLE-US-00009 CBD.sup.1 10 mg PL 90G 10 mg Mirinda 80 ml

Preparation Method:

[0038] PL 90G was well mixed and then mixed with CBD intermittently. Ten ml Mirinda were added gradually through mixing in a mortar and pestle. The obtained liquid was transferred into a glass vessel to which the remaining Mirinda volume was added gradually through mixing with an overhead stirrer at 700 rpm (Heidolph RZR 2000 Digital, Heidolph Instruments, Germany). The obtained composition was further homogenized for 10 cycles in a high-pressure homogenizer (M-110P Microfluidizer®: A “Plug and Play” Electric Benchtop Laboratory Homogenizer, Microfluidics, USA).

Example 8

[0039]

TABLE-US-00010 CBD.sup.1 10 mg PL 90G 5 mg Mineral Water 80 ml

Preparation Method:

[0040] Phospholipid was intermittently mixed with CBD for about one hour. A part of Mineral Water was added gradually. The remaining Mineral Water volume was then added gradually through mixing at a high shear rate. The obtained composition was homogenized using an ultrasonic processor and then in a high-pressure homogenizer.

Example 9

[0041]

TABLE-US-00011 CBD.sup.1 10 mg PL 90G 5 mg Mirinda 80 ml

Preparation Method:

[0042] Phospholipid was mixed intermittently with CBD for about 1 hour. Then, ten ml Mirinda were added gradually through mixing in a mortar and pestle. The obtained liquid was transferred into a glass vessel to which the remaining Mirinda volume was added gradually through mixing with an overhead stirrer at 700 rpm (Heidolph RZR 2000 Digital, Heidolph Instruments, Germany). The obtained composition was homogenized using an ultrasonic processor (Scientz 950W Ultrasonic Sonicator/Homogenizer, Scientz, China) for 10 min and then further homogenized for 10 cycles in a high-pressure homogenizer (M-110P Microfluidizer®: A “Plug and Play” Electric Benchtop Laboratory Homogenizer, Microfluidics, USA).

Example 10

[0043]

TABLE-US-00012 CBD.sup.1 1 mg Sunlipon ® 90 1 mg Nestle Water 17.5 ml

Preparation Method:

[0044] Phospholipid was worked well, then intermittently mixed with CBD. The process was carried out at room temperature. Five hundred microliters Nestle Water were added gradually through mixing in a mortar and pestle. The obtained liquid was added to the remaining Nestle Water volume through mixing. The obtained composition was sonicated at a power rate of 40% (SONICS VCX750 Vibra Cell, PRO Scientific Inc, USA) then homogenized 5 times in a high-pressure homogenizer under 20000 psi (LV1 Low Volume Microfluidizer® Processor (Microfluidics, USA).

Example 11

[0045] a. Beverage Concentrate

TABLE-US-00013 CBD.sup.1 3 mg Sunlipon ® 90 3 mg Nestle Water 5.25 ml

Preparation Method:

[0046] Phospholipid was worked well, then mixed with CBD for about one hour with intermittent mixing. The process was carried out at room temperature. One ml Nestle Water was added gradually through mixing in a mortar and pestle, then the obtained liquid was transferred into a glass vessel to which the remaining Nestle Water volume was added through mixing at 800 rpm with an overhead stirrer (Heidolph Hei Torque value 200, Heidolph Instruments, Germany). The mixing was continued for another 10 min. The obtained composition was further processed by an ultrasonic apparatus at 50% power ratio for 10 min (Sonic 650WT-V2, Sonic Series, MRC LTD, Israel). After 1 hour, the composition was homogenized 15 times in a high-pressure homogenizer under 20000 psi (LV1 Low Volume Microfluidizer® Processor (Microfluidics, USA).

[0047] This concentrate Composition can be stored for further use.

[0048] b. Beverage Composition Using the Concentrate in Part a.

TABLE-US-00014 concentrate composition part a 2 ml Nestle Water 15 ml

Preparation Method:

[0049] Two ml of the concentrate were mixed with 15 ml Nestle Water and shaken for a few minutes.

Example 12

[0050]

TABLE-US-00015 CBD.sup.2 1 mg Sunlipon ® 90 1 mg Gatorade carrot 17.5 ml

Preparation Method:

[0051] Phospholipid was worked well then mixed with CBD intermittently for 10 min. A homogenous liquid was obtained. Five hundred microliters Gatorade carrot were then added in portions of 100 μl through mixing in a mortar and pestle. The liquid was homogenized using an ultrasonic processor at 50% power rate for 10 min (Sonic-650WT-V2, Sonic Series, MRC Ltd, Israel). Then this liquid was added to the remaining Gatorade carrot volume through mixing with an overhead stirrer at 800 rpm (Heidolph Hei Torque value 200, Heidolph Instruments, Germany). The mixing was continued for another 10 min.

Example 13

[0052]

TABLE-US-00016 CBD.sup.2 1 mg Sunlipon ® 90 1 mg Gatorade orange 17.5 ml

Preparation Method:

[0053] Phospholipid is worked well, then mixed with CBD. A homogenous liquid is obtained. Gatorade orange is then added in portions through mixing in a mortar apparatus, then this liquid is homogenized using ultrasonic processor. The sonicated liquid is added to the remaining Gatorade orange volume through mixing. The mixing is continued for another few minutes.

Example 14

[0054]

TABLE-US-00017 CBD.sup.2 1 mg Sunlipon ® 90 1 mg Gatorade red orange 17.5 ml

Preparation Method:

[0055] Phospholipid was worked well then mixed with CBD intermittently for 10 min. A homogenous liquid was obtained. Five hundred microliters Gatorade red orange were then added in portions of 100 μl through mixing in a mortar and pestle. Then this liquid was homogenized using an ultrasonic processor for 10 min at 50% power rate (Sonic-650WT-V2, Sonic Series, MRC Ltd, Israel). The sonicated liquid was added to the remaining Gatorade red orange volume through mixing with an overhead stirrer at 800 rpm (Heidolph Hei Torque value 200, Heidolph Instruments, Germany). The mixing was continued for another 10 min.

Example 15

[0056]

TABLE-US-00018 CBD.sup.2 1 mg Sunlipon ® 90 1 mg Gatorade blue 17.5 ml

Preparation Method:

[0057] Phospholipid was worked well, then mixed with CBD intermittently for 10 min, a homogenous liquid was obtained. Gatorade blue was then added in portions through mixing in a mortar apparatus. The liquid was then homogenized using an ultrasonic processor. The sonicated liquid was added to the Gatorade blue remaining volume through mixing. The mixing was continued for short time.

Example 16

[0058]

TABLE-US-00019 CBD.sup.1 2 mg PL90G 2 mg Prigat (Grapefruit soft drink) 35 ml

Preparation Method:

[0059] Phospholipid was worked well, then mixed with CBD intermittently for about one hour. A homogenous liquid was obtained. Ten ml Prigat (Grapefruit soft drink) were then added gradually through mixing in a mortar apparatus, then the obtained liquid was transferred to the remaining Prigat (Grapefruit soft drink) volume gradually through mixing. The composition was further homogenized using an ultrasonic processor for 10 min.

Example 17

[0060]

TABLE-US-00020 CBD.sup.1 2 mg PL90G 2 mg Fanta 35 ml

Preparation Method:

[0061] Phospholipid was worked in a mortar then mixed with CBD intermittently for about 60 minutes. A viscous liquid was obtained. Ten ml Fanta were then added gradually through mixing, then the obtained liquid was transferred into a glass vessel to which the remaining Fanta volume was added gradually through mixing with an overhead stirrer at 700 rpm (Heidolph RZR 2000 Digital, Heidolph Instruments, Germany). The composition was further homogenized using an ultrasonic processor for 10 min at 30% power rate (Sonic-650WT-V, Sonic Series, MRC Ltd, Israel).

Example 18

[0062]

TABLE-US-00021 CBD.sup.2 1 mg Sunlipon ® 90 0.75 mg Fanta 17.5 ml

Preparation Method:

[0063] The phospholipid was mixed in a mortar, then mixed with CBD intermittently for 10 min. A small volume of Fanta was added through mixing. Then this liquid was homogenized using an ultrasonic processor for 10 min at 50% power rate (Sonic-650WT-V, Sonic Series, MRC Ltd, Israel). The sonicated liquid was added to the remaining Fanta volume through mixing at 800 rpm with an overhead stirrer (Heidolph Hei Torque value 200, Heidolph Instruments, Germany). The mixing was continued for another 10 min.

Example 19

[0064]

TABLE-US-00022 CBD.sup.1 2 mg PL90G 2 mg Grapefruit soft drink (Prigat) 35 ml

Preparation Method:

[0065] The phospholipid was mixed well in a mortar, then mixed with CBD intermittently for about fifty minutes. A liquid was obtained. Ten ml of grapefruit soft drink were then added gradually through mixing. The obtained liquid was further homogenized for about ten minutes using an ultrasonic processor at 70% power rate (Sonic-650WT-V2, Sonic Series, MRC Ltd, Israel). The remaining soft drink volume was added gradually through mixing at 700 rpm with the Heidolph overhead stirrer. The mixing was continued for another few minutes.

Example 20

[0066]

TABLE-US-00023 CBD.sup.1 1 mg PL90G 1 mg PG 2 mg Red Bull 17.5 ml

Preparation Method:

[0067] The Phospholipid was mixed in a mortar then mixed with CBD intermittently for about 65 minutes. A liquid was obtained. Then PG was added and mixed well. Two ml Red Bull were then added gradually through mixing. The liquid was further homogenized using an ultrasonic processor. The remaining Red Bull volume was added gradually through mixing at 700 rpm with an overhead stirrer (Heidolph Hei Torque value 200, Heidolph Instruments, Germany). The mixing was continued for another five minutes.

Example 21 (Comparative)

[0068]

TABLE-US-00024 CBD.sup.1 2 mg Fanta 35 ml

Preparation Method:

[0069] CBD was placed and mixed in a mortar. Ten ml Fanta were added gradually through mixing, then the liquid was transferred into a glass vessel to which the remaining Fanta volume was added gradually through mixing at 700 rpm with an overhead stirrer (Heidolph RZR 2000 Digital, Heidolph Instruments, Germany). The obtained liquid was not homogenous. It was then processed for 10 min using an ultrasonic apparatus at 50% power rate (Sonic-650WT-V2, Sonic Series, MRC Ltd, Israel).

[0070] The resulted liquid was not homogenous, CBD particles were observed immediately after preparation.

Example 22 (Beverage Concentrate)

[0071]

TABLE-US-00025 CBD.sup.1 3 mg PL 90G 3 mg Sodium benzoate 30 mg Fanta 1.5 ml

Preparation Method:

[0072] The phospholipid was mixed well in a mortar, then mixed with CBD intermittently for about 60 minutes. A liquid was obtained. Fanta was then added in portions through mixing. Then Sodium benzoate was added with mixing. The composition was homogenized using an ultrasonic processor.

Example 23 (Beverage Concentrate)

[0073]

TABLE-US-00026 CBD.sup.1 3 mg PL 90G 3 mg Fanta 1.5 ml

Preparation Method:

[0074] The phospholipid was worked well in a mortar, then mixed with CBD intermittently for 1 hour. A liquid was obtained. Fanta was then added in portions through mixing. The composition was then homogenized using an ultrasonic processor.

Example 24

[0075]

TABLE-US-00027 CBD.sup.1 1 mg Sunlipon ® 90 1 mg Mirinda 17.5 ml

Preparation Method:

[0076] The phospholipid was worked well in a mortar, then mixed with CBD intermittently. A liquid was obtained. Five hundred microliters Mirinda were then added in portions of 100 μl through mixing. Then the liquid was homogenized using an ultrasonic processor for 10 min (Sonic-650WT-V2, Sonic Series, MRC Ltd, Israel) at 50% power rate. The sonicated liquid was added to the remaining Mirinda volume through mixing at 800 rpm with an overhead stirrer (Heidolph Hei Torque value 200, Heidolph Instruments, Germany). The mixing was continued for another few minutes.

Example 25

[0077]

TABLE-US-00028 CBD.sup.2 1 mg Sunlipon ® 90 1 mg Fanta 17.5 ml

Preparation Method:

[0078] The phospholipid was mixed well in a mortar, then mixed with CBD intermittently for 15 min. A liquid was obtained. Five hundred microliters Fanta were then added in portions of 100 through mixing. The obtained liquid was homogenized 10 min in an ultrasonic processor, at 50% power rate (Sonic-650WT-V2, Sonic Series, MRC Ltd, Israel). The sonicated liquid was added to the remaining Fanta volume through mixing at 800 rpm with an overhead stirrer (Heidolph Hei Torque value 200, Heidolph Instruments, Germany). The mixing was continued for another 10 minutes.

Example 26

[0079]

TABLE-US-00029 CBD.sup.2 2 mg Sunlipon ® 90 2 mg Grapefruit soft drink (Prigat) 35 ml

Preparation Method:

[0080] Sunlipon® 90 was mixed well in a mortar and pestle, then mixed with CBD intermittently for 10 min. A homogenous liquid was obtained. Five hundred microliters Prigat were then added in portions through mixing. Then the liquid was homogenized using an ultrasonic processor. The sonicated liquid was added to the remaining Prigat volume through mixing with an overhead stirrer (Heidolph Hei Torque value 200, Heidolph Instruments, Germany). The mixing was continued for another few minutes.

Example 27

[0081]

TABLE-US-00030 CBD.sup.2 1 mg Sunlipon ® 90 1 mg Tapuzina transparent apple soft drink 17.5 ml

Preparation Method:

[0082] Sunlipon® 90 was mixed well in a mortar, then mixed with CBD intermittently for minutes. A liquid was obtained. Five hundred microliters Tapuzina transparent apple soft drink were then added in portions through mixing. Then the liquid was homogenized using an ultrasonic processor. The sonicated liquid was added to the remaining soft drink volume through mixing with an overhead stirrer. The mixing was continued for another few minutes.

Example 28

[0083]

TABLE-US-00031 CBD.sup.2 1 mg Sunlipon ® 90 0.75 mg Gatorade orange 17.5 ml

Preparation Method:

[0084] The phospholipid was mixed well in a mortar, then mixed with CBD intermittently for 15 minutes. A liquid was obtained. Five hundred microliters Gatorade orange were then added in portions through mixing. Then the liquid was homogenized ten minutes using an ultrasonic processor. The sonicated liquid was added to the remaining Gatorade orange volume through mixing. The mixing was continued for about ten minutes

Example 29

[0085]

TABLE-US-00032 CBD.sup.2 1 mg Sunlipon ® 90 0.75 mg Gatorade blue 17.5 ml

Preparation Method:

[0086] Sunlipon® 90 was mixed well, then mixed with CBD intermittently for about 20 minutes. A liquid was obtained. A small amount of Gatorade blue was then added in portions through mixing. Then the liquid was homogenized using an ultrasonic processor. The sonicated liquid was added to the remaining Gatorade blue volume through mixing.

Example 30

[0087] a. Beverage Concentrate

TABLE-US-00033 CBD.sup.1 2 mg Sunlipon ® 90 2 mg Tapuzina transparent apple soft drink 3.5 ml

Preparation Method:

[0088] The phospholipid was worked well in a mortar, then mixed with CBD for about one hour with intermittent mixing. The process was carried out at room temperature. One ml Tapuzina was added gradually through mixing, then the obtained liquid was transferred into a glass vessel to which the remaining Tapuzina was added gradually through mixing with an overhead stirrer. The mixing was continued for another 10 min. The obtained composition was further homogenized 5 times in a high-pressure homogenizer under 20000 psi (LV1 Low Volume Microfluidizer® Processor (Microfluidics, USA).

[0089] The concentrate composition can be stored and used occasionally.

[0090] b. Beverage Composition Using the Concentrate in Part a.

TABLE-US-00034 concentrate composition part a 2 ml Tapuzina transparent apple soft 15 ml

Preparation Method:

[0091] Two ml of concentrate were mixed with 15 ml Tapuzina and vigorously shaken.

Example 31

[0092] a. Beverage Concentrate

TABLE-US-00035 CBD.sup.1 2 mg Sunlipon ® 90 2 mg Red Bull 3.5 ml

Preparation Method:

[0093] The phospholipid was mixed well in a mortar, then mixed with CBD for about one hour with intermittent mixing. The process was carried out at room temperature. One ml Red Bull was added gradually through mixing, then the obtained liquid was transferred into a vessel to which the remaining Red Bull volume was added through mixing. The mixing was continued for 10 min. The obtained composition was further homogenized 5 times in a high-pressure homogenizer.

[0094] The concentrate composition can be stored for further use.

[0095] b. Beverage Composition Using the Concentrate in Part a.

TABLE-US-00036 concentrate composition part a 2 ml Red Bull 15 ml

Preparation Method:

[0096] Two ml of concentrate were mixed with 15 ml Red Bull and shaken.

Example 32

[0097]

TABLE-US-00037 CBD.sup.1 2 mg PL90G 2 mg Tapuzina orange 35 ml

Preparation Method:

[0098] The phospholipid was mixed well, then mixed with CBD intermittently for 1 hour. A homogenous liquid was obtained. Ten ml Tapuzina orange were then added gradually through mixing. The remaining Tapuzina orange volume was added gradually through mixing. The composition was further homogenized using an ultrasonic processor.

Example 33

[0099]

TABLE-US-00038 CBD.sup.1 2 mg PL90G 1 mg Fanta 35 ml

Preparation Method:

[0100] The phospholipid was mixed well in a mortar, then mixed with CBD intermittently for 1 hour. A homogenous liquid was obtained. Ten ml Fanta were then added gradually through mixing. The liquid was further homogenized using an ultrasonic processor for 10 min (Sonic-650WT-V2, Sonic Series, MRC Ltd, Israel) at 70% power rate. The remaining Fanta volume was added gradually through mixing at 700 rpm with an overhead stirrer (Heidolph RZR 2000 Digital, Heidolph Instruments, Germany). The mixing was continued for additional 5 min.

Example 34

[0101]

TABLE-US-00039 CBD.sup.1 1 mg PL90G 1 mg Sodium benzoate 10 mg Fanta 17.5 ml

Preparation Method:

[0102] The phospholipid is mixed well in a mortar, then mixed with CBD intermittently for about one hour. A liquid is formed. Ten ml Fanta are then added gradually through mixing. Then Sodium benzoate is added with mixing. This liquid is further homogenized using an ultrasonic processor. The remaining Fanta volume is added gradually through mixing.

Example 35

[0103]

TABLE-US-00040 CBD.sup.1 1 mg Sunlipon ® 90 1 mg Bavaria 0.0% Alcohol 17.5 ml

Preparation Method:

[0104] The phospholipid was mixed well in a mortar, then mixed with CBD for about 1 hour with intermittent mixing. The process was carried out at room temperature. Five hundred microliters Bavaria 0.0% Alcohol were added gradually through mixing. The obtained liquid was added to the remaining Bavaria 0.0% Alcohol volume through mixing at 800 rpm with an overhead stirrer (Heidolph Hei Torque value 200, Heidolph Instruments, Germany). The mixing was continued for another 10 min. The obtained composition was further homogenized 5 times in a high-pressure homogenizer under 20000 psi (LV1 Low Volume Microfluidizer® Processor (Microfluidics, USA).

Example 36

[0105]

TABLE-US-00041 CBD.sup.1 1 mg Sunlipon ® 90 1 mg Stella Artois 5% Alcohol 17.5 ml

Preparation Method:

[0106] Sunlipon® 90 was mixed well in a mortar, then mixed with CBD for about one hour with intermittent mixing. The process was carried out at room temperature. Five hundred microliters Stella Artois 5% Alcohol were added gradually through mixing. The obtained liquid was added to the remaining Stella Artois 5% Alcohol volume through mixing. The mixing was continued for a few minutes. The obtained composition was further homogenized in a high-pressure homogenizer.

Example 37

[0107]

TABLE-US-00042 CBD.sup.1 1 mg Sunlipon ® 90 1 mg Starbucks chilled coffee drink 17.5 ml

Preparation Method:

[0108] Sunlipon® 90 was mixed well, then mixed with CBD for about one hour with intermittent mixing. The process was carried out at room temperature. Five hundred microliters Starbucks chilled coffee drink were added gradually through mixing. This liquid was added to the remaining Starbucks chilled coffee drink volume through mixing. The obtained composition was further homogenized in a high-pressure homogenizer.

Example 38

[0109]

TABLE-US-00043 CBD.sup.1 1 mg Sunlipon ® 90 1 mg Red Bull 17.5 ml

Preparation Method:

[0110] The phospholipid was mixed well, then mixed with CBD for about one hour with intermittent mixing. The process was carried out at room temperature. Five hundred microliters Red Bull were added gradually through mixing. This liquid was added to the remaining Red Bull volume through mixing with an overhead stirrer (Heidolph Hei Torque value 200, Heidolph Instruments, Germany). The mixing was continued for another 10 min. The obtained composition was further homogenized 10 times in a high-pressure homogenizer under 20000 psi (LV1 Low Volume Microfluidizer® Processor (Microfluidics, USA).

Example 39

[0111]

TABLE-US-00044 CBD.sup.1 3 mg Sunlipon 90 2 mg Fanta 35 ml

Preparation Method:

[0112] The phospholipid was mixed well in a mortar, then further mixed with CBD intermittently for about one hour. A liquid was obtained. Fanta was then added gradually to the obtained liquid through mixing. The composition was further homogenized using an ultrasonic processor.

Example 40

[0113]

TABLE-US-00045 CBD.sup.2 1 mg Sunlipon ® 90 0.75 mg Fanta 18 ml

Preparation Method:

[0114] The phospholipid was mixed in a mortar with pestle, then mixed with CBD intermittently for 10 min. A homogenous liquid was obtained. Five hundred microliters of Fanta were then added in portions of 100 μl through mixing. Then this liquid was homogenized for 10 min using the ultrasonic processor Sonic-650WT-V, Sonic Series, MRC Ltd, Israel, at 50% power rate. The sonicated liquid was added to the remaining Fanta volume through mixing at 800 rpm with an overhead stirrer (Heidolph Hei Torque value 200, Heidolph Instruments, Germany). The mixing was continued for another 15 min.

Example 41

[0115]

TABLE-US-00046 CBD.sup.2 30 g Sunlipon ® 90 25 g Fanta 35 L

Preparation Method:

[0116] Sunlipon® is mixed in a mortar or grinder for about one hour, then mixed with CBD intermittently for another hour. A liquid is obtained. A part of the Fanta is then added gradually through mixing. The obtained liquid can be homogenized using an ultrasonic processor. The sonicated liquid is then added to the remaining Fanta volume through mixing at a high sheer rate. The mixing is continued for another 20 minutes.

Example 42

[0117]

TABLE-US-00047 CBD.sup.2 1 mg Sunlipon ® 90 1 mg Mirinda 17.5 ml

Preparation Method:

[0118] Phospholipid was worked well then mixed with CBD intermittently for 10 min. A liquid was obtained. The liquid was added to Mirinda and homogenized using an ultrasonic processor. The homogenized liquid was further mixed with an overhead stirrer at a high sheer rate. The mixing was continued for another 10 min. The obtained composition was further homogenized using a high-pressure homogenizer.

Example 43

[0119]

TABLE-US-00048 CBD.sup.2 1.5 mg Sunlipon ® 90 1.5 mg Mirinda 17.5 ml

Preparation Method:

[0120] Phospholipid was worked well then mixed with CBD intermittently for 10 min. A homogenous liquid was obtained. The liquid was added to Mirinda and homogenized using an ultrasonic processor. The obtained composition was further homogenized using a high-pressure homogenizer.

Example 44

[0121]

TABLE-US-00049 CBD.sup.2 5 mg Sunlipon ® 90 5 mg Mirinda 35 ml

Preparation Method:

[0122] Phospholipid was worked well then mixed with CBD intermittently for 10 min. A homogenous liquid was obtained. The liquid was added to Mirinda and homogenized using an ultrasonic processor at 50% power rate for 10 min (Sonic-650WT-V2, Sonic Series, MRC Ltd, Israel). The homogenized liquid was further mixed for 10 min with an overhead stirrer at 800 rpm (Heidolph Hei Torque value 200, Heidolph Instruments, Germany). The obtained composition was further homogenized 5 times in a high-pressure homogenizer under 20000 psi (LV1 Low Volume Microfluidizer® Processor (Microfluidics, USA).

Example 45

[0123]

TABLE-US-00050 CBD.sup.2 3 mg Sunlipon ® 90 3 mg Mirinda 35 ml

Preparation Method:

[0124] Phospholipid was worked well then mixed with CBD intermittently for 10 min. A homogenous liquid was obtained. The liquid was added to Mirinda and homogenized for 10 min using an ultrasonic processor at a power rate of 40% (SONICS VCX750 Vibra Cell, PRO Scientific Inc, USA).

[0125] The obtained composition was further homogenized 5 times in a high-pressure homogenizer under 20000 psi (LV1 Low Volume Microfluidizer® Processor (Microfluidics, USA).

Example 46

[0126]

TABLE-US-00051 CBD.sup.2 30 g Sunlipon ® 90 25 g Mirinda 35 L

Preparation Method:

[0127] Sunlipon® is mixed in a mortar or grinder for about one hour, then mixed with CBD intermittently for another hour. A liquid is obtained. A part of Mirinda is added gradually through mixing. The obtained liquid is homogenized using an ultrasonic processor. The sonicated liquid is then added to the remaining volume of Mirinda through mixing at a high sheer rate. The mixing is continued for additional 30 minutes.