Topical hirsutism treatment

Abstract

Disclosed is a topical composition for the treatment of hirsutism comprising capryloyl glycine as active ingredient, mixed with dermatologically acceptable carriers.

Claims

1. Method of inhibiting growth of superfluous hair on a body in need thereof with a composition consisting of 1 to 20% by weight of capryloyl glycine as active ingredient in admixture with dermatologically acceptable excipients, said method comprising applying said composition to said body.

2. The method according to claim 1, wherein said composition is in the form of gel, cream, foam, ointment, lotion, spray, liquid.

3. The method according to claim 1 to inhibit the growth of hair on the face.

4. A method of treating hirsutism on a body in need thereof with a composition consisting of 1 to 20% by weight of capryloyl glycine as active ingredient in admixture with dermatologically acceptable excipients, said method comprising applying said composition to said body.

5. The method according to claim 4, wherein said composition is in the form of gel, cream, foam, ointment, lotion, spray, liquid.

6. The method according to claim 4, wherein said hirsutism is on the face.

7. The method according to claim 1, wherein the capryloyl glycine is present in an amount from 2.5 to 15% by weight.

8. The method according to claim 4, wherein the capryloyl glycine is present in an amount from 2.5 to 15% by weight.

Description

DESCRIPTION OF THE INVENTION

(1) It has now been found that capryloyl glycine, a lipoaminoacid conventionally used in various cosmetic compositions for its antimicrobial and pH-regulating properties, effectively combats hirsutism when applied topically.

(2) The present invention therefore relates to topical compositions for the treatment of hirsutism comprising capryloyl glycine as active ingredient, mixed with dermatologically acceptable carriers.

(3) The invention also relates to the cosmetic use of capryloyl glycine to inhibit the growth of hair on the body, especially the face.

(4) The formulations according to the invention can take any form suitable for topical administration, such as gel, cream, foam, ointment, lotion, spray or liquid.

(5) Capryloyl glycine is typically present in the formulations according to the invention in concentrations ranging from 1 to 20% by weight, and preferably from 2.5 to 15% by weight.

(6) The efficacy of the formulations can be further increased by adding other active ingredients, preferably selected from Curcuma longa extracts, soy extracts in general and Gymnema sylvestre extracts.

(7) The concentrations of said extracts can range from 0.1 to 5% by weight for Curcuma longa, 1 to 20% by weight for soy extracts, and 1 to 10% by weight for Gymnema sylvestre extracts. The formulations will preferably contain soy extracts in percentages ranging from 5 to 15% by weight.

(8) Suitable dermatological carriers include oil-in-water or water-in-oil emulsions, thickening agents, antifoaming agents, emulsifiers, surfactants, perfumes, polyethylene glycol ethers of alkyl alcohols, and ethylene oxide/propylene oxide copolymers.

(9) Other ornithine decarboxylase inhibitors, S-adenosylmethionine decarboxylase inhibitors, gamma-glutamyl transpeptidase inhibitors or transglutaminase inhibitors can also be added to the formulations if desired. For example, the formulations can include eflornithine, optionally in lower concentrations than those used to date and currently marketed. However, the presence of eflornithine is not necessary to produce the anti-hirsutism effects due to capryloyl glycine, which has proved fully effective even when not combined with other active ingredients.

(10) Said effects are probably due to properties involving inhibition of the enzyme ornithine decarboxylase. However, the usefulness of the invention is in no way dependent on verification of said hypothetical action mechanism.

(11) The invention is illustrated in greater detail in the examples below.

Example 1

(12) purified water 49.7%

(13) lipacide 5% (capryloyl glycine)

(14) propylene glycol 33%

(15) sepigel 3%

(16) cyclopentasiloxane 4%

(17) propyl paraben 0.1%

(18) methyl paraben 0.1%

(19) sodium hydrate to pH 5/5.5

(20) titrated soy extracts 5%

Example 2

(21) lipacide 10% (capryloyl glycine)

(22) propylene glycol 30%

(23) sepigel 3%

(24) cyclopentasiloxane 4%

(25) propyl paraben 0.1%

(26) methyl paraben 0.1%

(27) sodium hydrate to pH 5/5.5

(28) titrated soy extracts 5%

(29) water q.s.

Example 3

(30) Lipacide C8G (capryloyl glycine) 4%

(31) Palmatine supported in 5-micron nylon microbeads and suspended in an oily carrier (Depiline®) 2%

(32) Soya isoflavones 1.5%

(33) Vitamin PP 1.5%

Example 4

(34) The ability of capryloyl glycine to inhibit the growth of superfluous hair was evaluated by the Trichoscan® method (http://trichoscan.com/pages/english/professional-info/reference-values.php). A 10% capryloyl glycine cream proved to have an efficacy comparable to that of eflornithine, reported in Eur. J Dermatol 2008; 18 (1): 65-70.