4-(3,4-dihydronaphth-1-yl or 2H-chromen-4-yl)-5-hydroxy-2H-pyradizin-3-ones as herbicides

Abstract

Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, Formula (1) wherein W, R.sup.1, R.sup.2, R.sup.3, n, R.sup.4, R.sup.5, R.sup.6, L and G are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention. ##STR00001##

Claims

1. A compound selected from Formula 1, N-oxides and salts thereof, ##STR00031## wherein W is C(R.sup.7)(R.sup.8); R.sup.1 is H, C.sub.1C.sub.7 alkyl, C.sub.3-C.sub.8 alkylcarbonylalkyl, C.sub.3-C.sub.8 alkoxycarbonylalkyl, C.sub.4-C.sub.7 alkylcycloalkyl, C.sub.2-C.sub.7 alkenyl, C.sub.3-C.sub.7 alkynyl, C.sub.3-C.sub.7 cycloalkyl, C.sub.4-C.sub.7 cycloalkylalkyl, C.sub.2-C.sub.5 cyanoalkyl, C.sub.1-C.sub.4 nitroalkyl, C.sub.2-C.sub.7 haloalkoxyalkyl, C.sub.1-C.sub.7 haloalkyl, C.sub.2-C.sub.7 haloalkenyl, C.sub.2-C.sub.7 alkoxyalkyl, C.sub.3-C.sub.7 alkylthioalkyl or C.sub.1-C.sub.7 alkoxy; R.sup.2 is H, halogen, cyano, —CHO, C.sub.1-C.sub.7 alkyl, C.sub.3-C.sub.8 alkylcarbonylalkyl, C.sub.3-C.sub.8 alkoxycarbonylalkyl, C.sub.1-C.sub.4 alkylcarbonyl, C.sub.2-C.sub.7 alkylcarbonyloxy, C.sub.4-C.sub.7 alkylcycloalkyl, C.sub.2-C.sub.7 alkenyl, C.sub.3-C.sub.7 alkynyl, C.sub.1-C.sub.4 alkylsulfinyl, C.sub.1-C.sub.4 alkylsulfonyl, C.sub.1-C.sub.4 alkylamino, C.sub.2-C.sub.8 dialkylamino, C.sub.3-C.sub.7 cycloalkyl, C.sub.4-C.sub.7 cycloalkylalkyl, C.sub.2-C.sub.5 cyanoalkyl, C.sub.1-C.sub.4 nitroalkyl, C.sub.2-C.sub.7 haloalkoxyalkyl, C.sub.1-C.sub.7 haloalkyl, C.sub.2-C.sub.7 haloalkenyl, C.sub.2-C.sub.7 alkoxyalkyl, C.sub.1-C.sub.7 alkoxy, C.sub.1-C.sub.5 alkylthio or C.sub.2-C.sub.3 alkoxycarbonyl; each R.sup.3 is independently H, halogen, nitro, cyano, C.sub.1-C.sub.5 alkyl, C.sub.2-C.sub.5 alkenyl, C.sub.2-C.sub.5 alkynyl, C.sub.3-C.sub.5 cycloalkyl, C.sub.4-C.sub.5 cycloalkylalkyl, C.sub.1-C.sub.5 haloalkyl, C.sub.2-C.sub.5 haloalkenyl, C.sub.3-C.sub.5 haloalkynyl, C.sub.2-C.sub.5 alkoxyalkyl, C.sub.1-C.sub.5 alkoxy, C.sub.1-C.sub.5 haloalkoxy, C.sub.1-C.sub.5 alkylthio, C.sub.1-C.sub.4 alkylsulfinyl, C.sub.1-C.sub.4 alkylsulfonyl, C.sub.1-C.sub.4 haloalkylthio or C.sub.2-C.sub.5 alkoxycarbonyl; n is 0 to 3; each R.sup.4 is independently H, halogen, nitro, cyano, C.sub.1-C.sub.5 alkyl, C.sub.2-C.sub.5 alkenyl, C.sub.2-C.sub.5 alkynyl, C.sub.3-C.sub.5 cycloalkyl, C.sub.4-C.sub.5 cycloalkylalkyl, C.sub.1-C.sub.5 haloalkyl, C.sub.2-C.sub.5 haloalkenyl, C.sub.3-C.sub.5 haloalkynyl, C.sub.2-C.sub.5 alkoxyalkyl, C.sub.1-C.sub.5 alkoxy, C.sub.1-C.sub.5 haloalkoxy, C.sub.1-C.sub.5 alkylthio, C.sub.1-C.sub.4 alkylsulfinyl, C.sub.1-C.sub.4 alkylsulfonyl, C.sub.1-C.sub.4 haloalkylthio or C.sub.2-C.sub.5 alkoxycarbonyl; R.sup.5 is H or C.sub.1-C.sub.5 alkyl; R.sup.6 is H or C.sub.1-C.sub.5 alkyl; R.sup.7 is H or C.sub.1-C.sub.5 alkyl; R.sup.8 is H or C.sub.1-C.sub.5 alkyl; L is a direct bond, C.sub.1-C.sub.4 alkanediyl or C.sub.2-C.sub.4 alkenediyl; G is H, C(═O)R.sup.9, C(═S)R.sup.9, CO.sub.2R.sup.10, C(═O)SR.sup.10, S(O).sub.2R.sup.9, C(═O)N(R.sup.11)(R.sup.12), S(═O).sub.2N(R.sup.11)(R.sup.12) or P(═O)(R.sup.13)(R.sup.14), or C.sub.1-C.sub.7 alkyl, C.sub.2-C.sub.5 alkenyl, C.sub.2-C.sub.4 alkynyl, C.sub.1-C.sub.7 haloalkyl, C.sub.2-C.sub.5 haloalkenyl, C.sub.2-C.sub.4 haloalkynyl, C.sub.2-C.sub.4 alkoxyalkyl, C.sub.3-C.sub.6 cycloalkyl or C.sub.4-C.sub.7 cycloalkylalkyl; or a 5- or 6-membered heterocyclic ring optionally substituted by halogen, C.sub.1-C.sub.4 alkyl or C.sub.1-C.sub.4 haloalkyl; R.sup.9 and R.sup.11 are independently H, C.sub.1-C.sub.7 alkyl, C.sub.3-C.sub.7 alkenyl, C.sub.3-C.sub.7 alkynyl, C.sub.3-C.sub.7 cycloalkyl, C.sub.1-C.sub.7 haloalkyl, C.sub.3-C.sub.7 haloalkenyl, C.sub.2-C.sub.7 alkoxyalkyl or C.sub.4-C.sub.7 cycloalkylalkyl; or phenyl, benzyl, or a 5- to 6-membered heterocyclic ring, each phenyl, benzyl or heterocyclic ring optionally substituted by halogen, C.sub.1-C.sub.4 alkyl or C.sub.1-C.sub.4 haloalkyl; R.sup.10 is C.sub.1-C.sub.7 alkyl, C.sub.3-C.sub.7 alkenyl, C.sub.3-C.sub.7 alkynyl, C.sub.3-C.sub.7 cycloalkyl, C.sub.2-C.sub.7 haloalkyl, C.sub.3-C.sub.7 haloalkenyl, C.sub.2-C.sub.7 alkoxyalkyl or C.sub.4-C.sub.7 cycloalkylalkyl; or phenyl, benzyl or a 5- to 6-membered heterocyclic ring, each phenyl, benzyl or heterocyclic ring optionally substituted by halogen, C.sub.1-C.sub.4 alkyl or C.sub.1-C.sub.4 haloalkyl; R.sup.12 is H, C.sub.1-C.sub.7 alkyl, C.sub.2-C.sub.7 alkenyl, C.sub.2-C.sub.7 alkynyl, C.sub.3-C.sub.7 cycloalkyl, C.sub.4-C.sub.7 cycloalkylalkyl, C.sub.1-C.sub.7 haloalkyl or C.sub.2-C.sub.7 alkoxyalkyl; R.sup.13 is C.sub.1-C.sub.7 alkyl or C.sub.1-C.sub.7 alkoxy; and R.sup.14 is C.sub.1-C.sub.7 alkyl or C.sub.1-C.sub.7 alkoxy.

2. The compound of claim 1 wherein R.sup.1 is H, C.sub.1-C.sub.7 alkyl, C.sub.3-C.sub.8 alkylcarbonylalkyl, C.sub.3-C.sub.8 alkoxycarbonylalkyl, C.sub.4-C.sub.7 alkylcycloalkyl, C.sub.3-C.sub.7 cycloalkyl, C.sub.4-C.sub.7 cycloalkylalkyl, C.sub.1-C.sub.7 haloalkyl, C.sub.2-C.sub.7 haloalkenyl, C.sub.2-C.sub.7 alkoxyalkyl or C.sub.1-C.sub.7 alkoxy; R.sup.2 is H, halogen, cyano, —CHO, C.sub.1-C.sub.7 alkyl, C.sub.3-C.sub.8 alkylcarbonylalkyl, C.sub.3-C.sub.8 alkoxycarbonylalkyl, C.sub.1-C.sub.4 alkylcarbonyl, C.sub.2-C.sub.7 alkylcarbonyloxy, C.sub.4-C.sub.7 alkylcycloalkyl, C.sub.3-C.sub.7 cycloalkyl, C.sub.4-C.sub.7 cycloalkylalkyl, C.sub.2-C.sub.7 haloalkoxyalkyl, C.sub.1-C.sub.7 haloalkyl, C.sub.2-C.sub.7 alkoxyalkyl, C.sub.1-C.sub.7 alkoxy, C.sub.1-C.sub.5 alkylthio or C.sub.2-C.sub.3 alkoxycarbonyl; each R.sup.3 is independently H, halogen, C.sub.1-C.sub.5 alkyl, C.sub.3-C.sub.5 cycloalkyl, C.sub.1-C.sub.5 haloalkyl, C.sub.1-C.sub.5 alkoxy or C.sub.1-C.sub.5 haloalkoxy; n is 0 to 2; R.sup.4 is H, halogen, C.sub.1-C.sub.3 alkyl, C.sub.3-C.sub.4 cycloalkyl, C.sub.1-C.sub.3 haloalkyl or C.sub.1-C.sub.3 alkoxy; L is a direct bond or C.sub.1-C.sub.2 alkanediyl; G is H, C(═O)R.sup.9, C(═S)R.sup.9, CO.sub.2R.sup.10, C(═O)SR.sup.10, CON(R.sup.11)(R.sup.12) or P(═O)(R.sup.13)(R.sup.14); or C.sub.1-C.sub.4 alkyl, C.sub.2-C.sub.4 alkenyl, C.sub.2-C.sub.4 alkynyl, C.sub.1-C.sub.4 haloalkyl, C.sub.2-C.sub.4 haloalkenyl, C.sub.2-C.sub.4 haloalkynyl, C.sub.2-C.sub.4 alkoxyalkyl, C.sub.3-C.sub.6 cycloalkyl or C.sub.4-C.sub.7 cycloalkylalkyl; R.sup.9 and R.sup.11 are independently H, C.sub.1-C.sub.7 alkyl, C.sub.3-C.sub.7 alkenyl, C.sub.3-C.sub.7 alkynyl, C.sub.3-C.sub.7 cycloalkyl or C.sub.1-C.sub.7 haloalkyl; or phenyl, benzyl, or a 6-membered heterocyclic ring, each phenyl, benzyl or heterocyclic ring optionally substituted by halogen, C.sub.1-C.sub.4 alkyl or C.sub.1-C.sub.4 haloalkyl; R.sup.10 is C.sub.1-C.sub.7 alkyl, C.sub.3-C.sub.7 alkenyl, C.sub.3-C.sub.7 cycloalkyl, C.sub.2-C.sub.7 haloalkyl or C.sub.3-C.sub.7 haloalkenyl; or phenyl, benzyl or a 6-membered heterocyclic ring, each phenyl, benzyl or heterocyclic ring optionally substituted by halogen, C.sub.1-C.sub.4 alkyl or C.sub.1-C.sub.4 haloalkyl; R.sup.12 is H, C.sub.1-C.sub.7 alkyl, C.sub.2-C.sub.7 alkenyl, C.sub.2-C.sub.7 alkynyl or C.sub.3-C.sub.7 cycloalkyl; R.sup.13 is C.sub.1-C.sub.4 alkyl or C.sub.1-C.sub.4 alkoxy; and R.sup.14 is C.sub.1-C.sub.4 alkyl or C.sub.1-C.sub.4 alkoxy.

3. The compound of claim 2 wherein R.sup.1 is H, C.sub.1-C.sub.7 alkyl, C.sub.3-C.sub.8 alkylcarbonylalkyl, C.sub.3-C.sub.8 alkoxycarbonylalkyl, C.sub.4-C.sub.7 alkylcycloalkyl, C.sub.3-C.sub.7 cycloalkyl, C.sub.4-C.sub.7 cycloalkylalkyl, C.sub.2-C.sub.7 alkoxyalkyl or C.sub.1-C.sub.7 alkoxy; R.sup.2 is H, halogen, cyano, —CHO, C.sub.1-C.sub.7 alkyl, C.sub.4-C.sub.7 alkylcycloalkyl, C.sub.3-C.sub.7 cycloalkyl, C.sub.4-C.sub.7 cycloalkylalkyl, C.sub.2-C.sub.7 haloalkoxyalkyl, C.sub.1-C.sub.7 haloalkyl, C.sub.2-C.sub.7 alkoxyalkyl, C.sub.1-C.sub.7 alkoxy or C.sub.1-C.sub.5 alkylthio; each R.sup.3 is independently H, halogen, C.sub.1-C.sub.5 alkyl, C.sub.1-C.sub.5 haloalkyl, C.sub.1-C.sub.5 alkoxy or C.sub.1-C.sub.5 haloalkoxy; n is 0 or 1; R.sup.4 is H, halogen, C.sub.1-C.sub.2 alkyl, cyclopropyl or C.sub.1-C.sub.2 haloalkyl; L is a direct bond; G is H, C(═O)R.sup.9, CO.sub.2R.sup.10, CON(R.sup.11)(R.sup.12) or P(═O)(R.sup.13)(R.sup.14); or C.sub.1-C.sub.4 alkyl, C.sub.2-C.sub.4 alkenyl, C.sub.1-C.sub.4 haloalkyl, C.sub.2-C.sub.4 haloalkenyl, C.sub.2-C.sub.4 alkoxyalkyl, C.sub.3-C.sub.6 cycloalkyl or C.sub.4-C.sub.7 cycloalkylalkyl; R.sup.9 and R.sup.11 are independently H, C.sub.1-C.sub.7 alkyl or C.sub.3-C.sub.7 alkenyl; or phenyl, benzyl, each phenyl or benzyl optionally substituted by halogen, C.sub.1-C.sub.4 alkyl or C.sub.1-C.sub.4 haloalkyl; R.sup.10 is C.sub.1-C.sub.7 alkyl or C.sub.3-C.sub.7 cycloalkyl; or phenyl or benzyl, each phenyl or benzyl optionally substituted by halogen, C.sub.1-C.sub.4 alkyl or C.sub.1-C.sub.4 haloalkyl; R.sup.12 is H, C.sub.1-C.sub.7 alkyl or C.sub.3-C.sub.7 cycloalkyl; R.sup.13 is C.sub.1-C.sub.2 alkyl or C.sub.1-C.sub.2 alkoxy; and R.sup.14 is C.sub.1-C.sub.2 alkyl or C.sub.1-C.sub.2 alkoxy.

4. The compound of claim 3 wherein R.sup.1 is H, C.sub.1-C.sub.7 alkyl, C.sub.4-C.sub.7 alkylcycloalkyl, C.sub.3-C.sub.7 cycloalkyl, C.sub.4-C.sub.7 cycloalkylalkyl or C.sub.2-C.sub.7 alkoxyalkyl; R.sup.2 is H, halogen, cyano, C.sub.1-C.sub.7 alkyl, C.sub.2-C.sub.7 haloalkoxyalkyl, C.sub.1-C.sub.7 haloalkyl, C.sub.2-C.sub.7 alkoxyalkyl, C.sub.1-C.sub.7 alkoxy or C.sub.1-C.sub.5 alkylthio; each R.sup.3 is independently H, halogen, methyl, ethyl, CF.sub.3 or —OCHF.sub.2; R.sup.4 is H, halogen, methyl, ethyl or CF.sub.3; G is H, C(═O)R.sup.9, CO.sub.2R.sup.10 or P(═O)(R.sup.13)(R.sup.14); or C.sub.1-C.sub.4 alkyl, C.sub.1-C.sub.4 haloalkyl, C.sub.2-C.sub.4 alkoxyalkyl or C.sub.3-C.sub.6 cycloalkyl; R.sup.9 is H or C.sub.1-C.sub.7 alkyl; or benzyl optionally substituted by halogen, C.sub.1-C.sub.4 alkyl or C.sub.1-C.sub.4 haloalkyl; and R.sup.10 is C.sub.1-C.sub.7 alkyl; or phenyl optionally substituted by halogen, C.sub.1-C.sub.4 alkyl or C.sub.1-C.sub.4 haloalkyl.

5. The compound of claim 4 wherein R.sup.1 is H, C.sub.1-C.sub.7 alkyl, C.sub.3-C.sub.7 cycloalkyl, C.sub.4-C.sub.7 cycloalkylalkyl or C.sub.2-C.sub.7 alkoxyalkyl; R.sup.2 is H, halogen, cyano, C.sub.1-C.sub.7 alkyl, C.sub.1-C.sub.7 haloalkyl or C.sub.1-C.sub.7 alkoxy; each R.sup.3 is independently H, F, Cl, Br or methyl; R.sup.4 is H, F, Cl, Br or methyl; R.sup.5 is H or methyl; R.sup.6 is H or methyl; R.sup.7 is H or methyl; R.sup.8 is H or methyl; G is H, C(═O)R.sup.9 or CO.sub.2R.sup.10; or C.sub.2-C.sub.4 alkoxyalkyl or C.sub.3-C.sub.6 cycloalkyl; R.sup.9 is C.sub.1-C.sub.7 alkyl; or benzyl optionally substituted by halogen, C.sub.1-C.sub.4 alkyl or C.sub.1-C.sub.4 haloalkyl; and R.sup.10 is CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, Ph, Ph(4-Cl), Ph(3-CF.sub.3) or Ph(4-CF.sub.3).

6. The compound of claim 5 wherein R.sup.1 is H, C.sub.1-C.sub.7 alkyl, C.sub.3-C.sub.7 cycloalkyl or C.sub.2-C.sub.7 alkoxyalkyl; R.sup.2 is H, Cl, Br, I, cyano, methyl, CF.sub.3 or methoxy; n is 0; R.sup.4 is methyl; R.sup.5 is H; R.sup.6 is H; R.sup.7 is H; R.sup.8 is H; and G is H.

7. A compound of claim 1 that is 4-(3,4-dihydro-2-methyl-1-naphthalenyl)-5-hydroxy-2,6-dimethyl-3-(2H)-pyridazinone.

8. A herbicidal composition comprising a compound of claim 1 and at least one component selected from the group consisting of surfactants, solid diluents and liquid diluents.

Description

EXAMPLE 1

Synthesis of 4-(3,4-dihydro-2-methyl-1-naphthalenyl)-5-methoxy-2,6-dimethyl-3(2H)-pyridazinone (Compound 1)

Step A: Preparation of 3,4-dihydro-2-methyl-1-naphthalenyl-1,1,2,2,3,3,4,4,4-nonafluoro-1-butanesulfonate

(1) To a solution of 2-methyl-1-tetralone (0.5 g, 3.1 mmol) in tetrahydrofuran (15 mL) at −78° C. was added lithium bis(trimethylsilyl)amide (1 M in tetrahydrofuran 3.7 mL, 3.7 mmol). The reaction mixture was stirred for 30 min. then perflouro-1-butanesulfonyl fluoride (1.2 g, 4.0 mmol) was added, and the resulting solution was allowed to warm to ambient temperature. After 30 min. the mixture was concentrated onto Celite® diatomaceaous earth filter aid and purified via silica gel chromatography using a gradient of ethyl acetate in hexanes as eluent to provide 0.97 g of the title compound.

(2) .sup.1H NMR δ 7.30-7.34 (m, 1H), 7.17-7.29 (m, 2H), 7.12-7.17 (m, 1H), 2.85 (m, 2H), 2.44 (m, 2H), 2.00 (s, 3H).

Step B: Preparation of 4-(3,4-dihydro-2-methyl-1-naphthalenyl)-5-methoxy-2,6-dimethyl-3(2H)-pyridazinone

(3) A reaction vessel was purged with nitrogen and charged with 5-methoxy-2,6-dimethyl-3(2H)-pyridazinone (0.2 g, 1.3 mmol), 3,4-dihydro-2-methyl-1-naphthalenyl-1,1,2,2,3,3,4,4,4-nonafluoro-1-butanesulfonate (i.e. the compound from Step A) (0.57 g, 1.3 mmol), SPhos pre-catalyst-G2 (chloro(2-dicyclohexylphosphino-2′,6′-dimethoxy-1,1′-biphenyl) [2-(2′-amino-1,1′-biphenyl)]palladium(II), (0.05 g, 0.07 mmol), and tetrahydrofuran (5 mL). Bis(2,2,6,6-tetramethylpiperidinyl)zinc, lithium chloride, magnesium chloride complex (1.6 mL, 1.6 mmol) was added and the solution was heated at 50° C. overnight. The resulting mixture was concentrated onto Celite® diatomaceaous earth filter aid and purified via silica gel chromatography eluting with a gradient of ethyl acetate in hexanes to provide 0.32 g of the title compound, a compound of the invention.

(4) .sup.1H NMR δ 7.11-7.15 (m, 1H), 7.06-7.11 (m, 2H), 6.71-6.76 (m, 1H), 3.71 (d, 6H), 2.99-3.04 (m, 1H), 2.78-2.83 (m, 1H), 2.34-2.48 (m, 2H), 2.28 (s, 3H), 1.77 (s, 3H).

EXAMPLE 2

Synthesis of 4-(3,4-dihydro-2-methyl-1-naphthalenyl)-5-hydroxy-2,6-dimethyl-3(2H)-pyridazinone (Compound 2)

Step A: Preparation of 4-(3,4-dihydro-2-methyl-1-naphthalenyl)-5-hydroxy-2,6-dimethyl-3(2H)-pyridazinone

(5) A solution of the 4-(3,4-dihydro-2-methyl-1-naphthalenyl)-5-methoxy-2,6-dimethyl-3(2H)-pyridazinone (i.e. the product from Step B above) (0.2 g, 0.68 mmol) and morpholine (2 mL) were heated at 120° C. for 40 min. The resulting solution was cooled to ambient temperature and 1 N aqueous hydrochloric acid (50 mL) and isopropanol (0.5 mL) were added. The resulting mixture was stirred for 10 min and the resulting solid that formed was filtered and washed with water. The solid was dried under vacuum to give 0.16 g of the title compound, a compound of the invention.

(6) .sup.1H NMR δ 7.03-7.17 (m, 3H), 6.66-6.75 (m, 1H), 5.50 (s, 1H), 3.75 (s, 3H), 2.94-3.05 (m, 1H), 2.79-2.90 (m, 1H), 2.39-2.56 (m, 2H), 2.33 (s, 3H), 1.80 (s, 3H).

EXAMPLE 3

Synthesis of 5-hydroxy-2,6-dimethyl-4-(3-methyl-2H-1-benzopyran-4-yl)-3(2H)-pyridazinone (Compound 3)

Step A: Preparation of 3-methyl-2H-1-benzopyran-4-yl 1,1,2,2,3,3,4,4,4-nonafluoro-1-butanesulfonate

(7) To a solution of 3-methyl-4-chromanone (1.0 g, 6.2 mmol) in tetrahydrofuran (12 mL) at −78° C. was added lithium bis(trimethylsilyl)amide (1 M in tetrahydrofuran, 3.7 mL, 3.7 mmol). The reaction was stirred for 10 min then perflouro-1-butanesulfonyl fluoride (2.6 g, 8.7 mmol) was added, and the resulting mixture was allowed to warm to ambient temperature. After 30 min the mixture was concentrated onto Celite® diatomaceaous earth filter aid, and purified via silica gel chromatography with ethyl acetate in hexanes as eluent to provide 1.2 g of the title compound.

(8) .sup.1H NMR δ 7.16-7.24 (m, 2H), 6.93-7.00 (m, 1H), 6.81-6.86 (m, 1H), 4.81 (s, 2H), 1.86-1.92 (m, 3H).

Step B: Preparation of 5-methoxy-2,6-dimethyl-4-(3-methyl-2H-1-benzopyran-4-yl)-3(2H)-pyridazinone

(9) A reaction vessel was purged with nitrogen and charged with 5-methoxy-2,6-dimethyl-3(2H)-pyridazinone (0.2 g, 1.3 mmol), 3-methyl-2H-1-benzopyran-4-yl 1,1,2,2,3,3,4,4,4-nonafluoro-1-butanesulfonate (i.e. the product from Step A) (0.58 g, 1.3 mmol), SPhos pre-catalyst-G2 (chloro(2-dicyclohexylphosphino-2′,6′-dimethoxy-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II), 0.05 g, 0.07 mmol), and tetrahydrofuran (5 mL). Bis(2,2,6,6-tetramethylpiperidinyl)zinc, lithium chloride, magnesium chloride complex (1.6 mL, 1.6 mmol) was added and the solution was heated at 50° C. overnight. The resulting mixture was concentrated onto Celite® diatomaceaous earth filter aid and purified via silica gel chromatography eluting with ethyl acetate in hexanes to provide 0.40 g of the title compound.

(10) .sup.1H NMR δ 7.04-7.11 (m, 1H), 6.80-6.86 (m, 2H), 6.67-6.72 (m, 1H), 4.87 (d, 1H), 4.71 (d, 1H), 3.71-3.78 (m, 6H), 2.28 (s, 3H), 1.67 (s, 3H).

Step C: Preparation of 5-hydroxy-2,6-dimethyl-4-(3-methyl-2H-1-benzopyran-4-yl)-3(2H)-pyridazinone

(11) A solution of 5-methoxy-2,6-dimethyl-4-(3-methyl-2H-1-benzopyran-4-yl)-3(2H)-pyridazinone (i.e. the product from Step B) (0.25 g, 0.88 mmol) and morpholine (2 mL) were heated at 120° C. for 30 min. The solution was concentrated to dryness in vacuo and 1 N aqueous hydrochloric acid (50 mL) and isopropanol (0.5 mL) were added. The resulting mixture was stirred for 10 min and the solid was filtered and washed with water. The solid was dried under vacuum to give 0.20 g of the title compound, a compound of the invention.

(12) .sup.1H NMR δ 7.03-7.11 (m, 1H), 6.76-6.83 (m, 2H), 6.63-6.68 (m, 1H), 4.82 (d, 1H), 4.64 (d, 1H), 3.70 (s, 3H), 2.31 (s, 3H), 1.60 (s, 3H).

(13) By the procedures described herein together with methods known in the art, the following compounds of Tables 1 to 959 can be prepared. The following abbreviations are used in the Tables which follow: Me means methyl, Et means ethyl, Pr means propyl, i-Pr means isopropyl, t-Bu means tertiarybutyl, OMe means methoxy, OEt means ethoxy, SMe means methylthio, SEt means ethylthio, —CN means cyano, and SO.sub.2Me means methylsulfonyl. A “-” in the (R.sup.3).sub.n column means n=0.

(14) TABLE-US-00001 TABLE 1 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is H and (R.sup.3).sub.n R.sup.4 (R.sup.3).sub.n R.sup.4 (R.sup.3).sub.n R.sup.4 — H 5-Pr H 6-CN H 5-Me H 6-Pr H 7-CN H 6-Me H 7-Pr H 5-CF.sub.3 H 7-Me H 5-OMe H 6-CF.sub.3 H 5-Et H 6-OMe H 7-CF.sub.3 H 6-Et H 7-OMe H 5-F H 7-Et H 5-CN H 6-F H 7-F H 7-CN Pr 7-Pr Br 5-Cl H 5-CF.sub.3 Pr 5-OMe Br 6-Cl H 6-CF.sub.3 Pr 6-OMe Br 7-Cl H 7-CF.sub.3 Pr 7-OMe Br 5-Br H 5-F Pr 5-CN Br 6-Br H 6-F Pr 6-CN Br 7-Br H 7-F Pr 7-CN Br 5-OCHF.sub.2 H 5-Cl Pr 5-CF.sub.3 Br 6-OCHF.sub.2 H 6-Cl Pr 6-CF.sub.3 Br 7-OCHF.sub.2 H 7-Cl Pr 7-CF.sub.3 Br 6,7-di-Me H 5-Br Pr 5-F Br 5,7-di-Me H 6-Br Pr 6-F Br 5-Cl, 7-Me H 7-Br Pr 7-F Br 5-Cl, 7-OMe H 5-OCHF.sub.2 Pr 5-Cl Br 5-F, 7-Me H 6-OCHF.sub.2 Pr 6-Cl Br 5-Me, 7-F H 7-OCHF.sub.2 Pr 7-Cl Br 5-Me, 7-Cl H 6,7-di-Me Pr 5-Br Br 5-Me, 7-CN H 5,7-di-Me Pr 6-Br Br 5-Me, 7-OMe H 5-Cl, 7-Me Pr 7-Br Br 5,7-di-F H 5-Cl, 7-OMe Pr 5-OCHF.sub.2 Br 5,7-di-Cl H 5-F, 7-Me Pr 6-OCHF.sub.2 Br 5,7-di-Br H 5-Me, 7-F Pr 7-OCHF.sub.2 Br — Pr 5-Me, 7-Cl Pr 6,7-di-Me Br 5-Me Pr 5-Me, 7-CN Pr 5,7-di-Me Br 6-Me Pr 5-Me, 7-OMe Pr 5-Cl, 7-Me Br 7-Me Pr 5,7-di-F Pr 5-Cl, 7-OMe Br 5-Et Pr 5,7-di-Cl Pr 5-F, 7-Me Br 6-Et Pr 5,7-di-Br Pr 5-Me, 7-F Br 7-Et Pr — Br 5-Me, 7-Cl Br 5-Pr Pr 5-Me Br 5-Me, 7-CN Br 6-Pr Pr 6-Me Br 5-Me, 7-OMe Br 7-Pr Pr 7-Me Br 5,7-di-F Br 5-OMe Pr 5-Et Br 5,7-di-Cl Br 6-OMe Pr 6-Et Br 5,7-di-Br Br 7-OMe Pr 7-Et Br — OMe 5-CN Pr 5-Pr Br 5-Me OMe 6-CN Pr 6-Pr Br 6-Me OMe 7-Me OMe 5,7-di-F OMe 5-Cl, 7-OMe SCHF.sub.2 5-Et OMe 5,7-di-Cl OMe 5-F, 7-Me SCHF.sub.2 6-Et OMe 5,7-di-Br OMe 5-Me, 7-F SCHF.sub.2 7-Et OMe — SCHF.sub.2 5-Me, 7-Cl SCHF.sub.2 5-Pr OMe 5-Me SCHF.sub.2 5-Me, 7-CN SCHF.sub.2 6-Pr OMe 6-Me SCHF.sub.2 5-Me, 7-OMe SCHF.sub.2 7-Pr OMe 7-Me SCHF.sub.2 5,7-di-F SCHF.sub.2 5-OMe OMe 5-Et SCHF.sub.2 5,7-di-Cl SCHF.sub.2 6-OMe OMe 6-Et SCHF.sub.2 5,7-di-Br SCHF.sub.2 7-OMe OMe 7-Et SCHF.sub.2 — Me 5-CN OMe 5-Pr SCHF.sub.2 5-Me Me 6-CN OMe 6-Pr SCHF.sub.2 6-Me Me 7-CN OMe 7-Pr SCHF.sub.2 7-Me Me 5-CF.sub.3 OMe 5-OMe SCHF.sub.2 5-Et Me 6-CF.sub.3 OMe 6-OMe SCHF.sub.2 6-Et Me 7-CF.sub.3 OMe 7-OMe SCHF.sub.2 7-Et Me 5-F OMe 5-CN SCHF.sub.2 5-Pr Me 6-F OMe 6-CN SCHF.sub.2 6-Pr Me 7-F OMe 7-CN SCHF.sub.2 7-Pr Me 5-Cl OMe 5-CF.sub.3 SCHF.sub.2 5-OMe Me 6-Cl OMe 6-CF.sub.3 SCHF.sub.2 6-OMe Me 7-Cl OMe 7-CF.sub.3 SCHF.sub.2 7-OMe Me 5-Br OMe 5-F SCHF.sub.2 5-CN Me 6-Br OMe 6-F SCHF.sub.2 6-CN Me 7-Br OMe 7-F SCHF.sub.2 7-CN Me 5-OCHF.sub.2 OMe 5-Cl SCHF.sub.2 5-CF.sub.3 Me 6-OCHF.sub.2 OMe 6-Cl SCHF.sub.2 6-CF.sub.3 Me 7-OCHF.sub.2 OMe 7-Cl SCHF.sub.2 7-CF.sub.3 Me 6,7-di-Me OMe 5-Br SCHF.sub.2 5-F Me 5,7-di-Me OMe 6-Br SCHF.sub.2 6-F Me 5-Cl, 7-Me OMe 7-Br SCHF.sub.2 7-F Me 5-Cl, 7-OMe OMe 5-OCHF.sub.2 SCHF.sub.2 5-Cl Me 5-F, 7-Me OMe 6-OCHF.sub.2 SCHF.sub.2 6-Cl Me 5-Me, 7-F OMe 7-OCHF.sub.2 SCHF.sub.2 7-Cl Me 5-Me, 7-Cl OMe 6,7-di-Me SCHF.sub.2 5-Br Me 5-Me, 7-CN OMe 5,7-di-Me SCHF.sub.2 6-Br Me 5-Me, 7-OMe OMe 5-Cl, 7-Me SCHF.sub.2 7-Br Me 5-OCHF.sub.2 Me 5-Cl F 5-CF.sub.3 CN 6-OCHF.sub.2 Me 6-Cl F 6-CF.sub.3 CN 7-OCHF.sub.2 Me 7-Cl F 7-CF.sub.3 CN 6,7-di-Me Me 5-Br F 5-F CN 5,7-di-Me Me 6-Br F 6-F CN 5-Cl, 7-Me Me 7-Br F 7-F CN 5-Cl, 7-OMe Me 5-OCHF.sub.2 F 5-Cl CN 5-F, 7-Me Me 6-OCHF.sub.2 F 6-Cl CN 5-Me, 7-F Me 7-OCHF.sub.2 F 7-Cl CN 5-Me, 7-Cl Me 6,7-di-Me F 5-Br CN 5-Me, 7-CN Me 5,7-di-Me F 6-Br CN 5-Me, 7-OMe Me 5-Cl, 7-Me F 7-Br CN 5,7-di-F Me 5-Cl, 7-OMe F 5-OCHF.sub.2 CN 5,7-di-Cl Me 5-F, 7-Me F 6-OCHF.sub.2 CN 5,7-di-Br Me 5-Me, 7-F F 7-OCHF.sub.2 CN — F 5-Me, 7-Cl F 6,7-di-Me CN 5-Me F 5-Me, 7-CN F 5,7-di-Me CN 6-Me F 5-Me, 7-OMe F 5-Cl, 7-Me CN 7-Me F 5,7-di-F F 5-Cl, 7-OMe CN 5-Et F 5,7-di-Cl F 5-F, 7-Me CN 6-Et F 5,7-di-Br F 5-Me, 7-F CN 7-Et F — CN 5-Me, 7-Cl CN 5-Pr F 5-Me CN 5-Me, 7-CN CN 6-Pr F 6-Me CN 5-Me, 7-OMe CN 7-Pr F 7-Me CN 5,7-di-F CN 5-OMe F 5-Et CN 5,7-di-Cl CN 6-OMe F 6-Et CN 5,7-di-Br CN 7-OMe F 7-Et CN — OCHF.sub.2 5-CN F 5-Pr CN 5-Me OCHF.sub.2 6-CN F 6-Pr CN 6-Me OCHF.sub.2 7-CN F 7-Pr CN 7-Me OCHF.sub.2 5-CF.sub.3 F 5-OMe CN 5-Et OCHF.sub.2 6-CF.sub.3 F 6-OMe CN 6-Et OCHF.sub.2 7-CF.sub.3 F 7-OMe CN 7-Et OCHF.sub.2 5-F F 5-CN CN 5-Pr OCHF.sub.2 6-F F 6-CN CN 6-Pr OCHF.sub.2 7-F F 7-CN CN 7-Pr OCHF.sub.2 5-OMe OCHF.sub.2 5-Et SCF.sub.3 5,7-di-Cl SCF.sub.3 6-OMe OCHF.sub.2 6-Et SCF.sub.3 5,7-di-Br SCF.sub.3 7-OMe OCHF.sub.2 7-Et SCF.sub.3 — Et 5-CN OCHF.sub.2 5-Pr SCF.sub.3 5-Me Et 6-CN OCHF.sub.2 6-Pr SCF.sub.3 6-Me Et 7-CN OCHF.sub.2 7-Pr SCF.sub.3 7-Me Et 5-CF.sub.3 OCHF.sub.2 5-OMe SCF.sub.3 5-Et Et 6-CF.sub.3 OCHF.sub.2 6-OMe SCF.sub.3 6-Et Et 7-CF.sub.3 OCHF.sub.2 7-OMe SCF.sub.3 7-Et Et 5-F OCHF.sub.2 5-CN SCF.sub.3 5-Pr Et 6-F OCHF.sub.2 6-CN SCF.sub.3 6-Pr Et 7-F OCHF.sub.2 7-CN SCF.sub.3 7-Pr Et 5-Cl OCHF.sub.2 5-CF.sub.3 SCF.sub.3 5-OMe Et 6-Cl OCHF.sub.2 6-CF.sub.3 SCF.sub.3 6-OMe Et 7-Cl OCHF.sub.2 7-CF.sub.3 SCF.sub.3 7-OMe Et 5-Br OCHF.sub.2 5-F SCF.sub.3 5-CN Et 6-Br OCHF.sub.2 6-F SCF.sub.3 6-CN Et 7-Br OCHF.sub.2 7-F SCF.sub.3 7-CN Et 5-OCHF.sub.2 OCHF.sub.2 5-Cl SCF.sub.3 5-CF.sub.3 Et 6-OCHF.sub.2 OCHF.sub.2 6-Cl SCF.sub.3 6-CF.sub.3 Et 7-OCHF.sub.2 OCHF.sub.2 7-Cl SCF.sub.3 7-CF.sub.3 Et 6,7-di-Me OCHF.sub.2 5-Br SCF.sub.3 5-F Et 5,7-di-Me OCHF.sub.2 6-Br SCF.sub.3 6-F Et 5-Cl, 7-Me OCHF.sub.2 7-Br SCF.sub.3 7-F Et 5-Cl, 7-OMe OCHF.sub.2 5-OOCHF.sub.2 SCF.sub.3 5-Cl Et 5-F, 7-Me OCHF.sub.2 6-OCHF.sub.2 SCF.sub.3 6-Cl Et 5-Me, 7-F OCHF.sub.2 7-OCHF.sub.2 SCF.sub.3 7-Cl Et 5-Me, 7-Cl OCHF.sub.2 6,7-di-Me SCF.sub.3 5-Br Et 5-Me, 7-CN OCHF.sub.2 5,7-di-Me SCF.sub.3 6-Br Et 5-Me, 7-OMe OCHF.sub.2 5-Cl, 7-Me SCF.sub.3 7-Br Et 5,7-di-F OCHF.sub.2 5-Cl, 7-OMe SCF.sub.3 5-OCHF.sub.2 Et 5,7-di-Cl OCHF.sub.2 5-F, 7-Me SCF.sub.3 6-OCHF.sub.2 Et 5,7-di-Br OCHF.sub.2 5-Me, 7-F SCF.sub.3 7-OCHF.sub.2 Et — SCF.sub.3 5-Me, 7-Cl SCF.sub.3 6,7-di-Me Et 5-Me SCF.sub.3 5-Me, 7-CN SCF.sub.3 5,7-di-Me Et 6-Me SCF.sub.3 5-Me, 7-OMe SCF.sub.3 5-Cl, 7-Me Et 7-Me SCF.sub.3 5,7-di-F SCF.sub.3 5-Cl, 7-OMe Et 5-F, 7-Me Et 6-OCHF.sub.2 Cl 6-Cl C≡CH 5-Me, 7-F Et 7-OCHF.sub.2 Cl 7-Cl C≡CH 5-Me, 7-Cl Et 6,7-di-Me Cl 5-Br C≡CH 5-Me, 7-CN Et 5,7-di-Me Cl 6-Br C≡CH 5-Me, 7-OMe Et 5-Cl, 7-Me Cl 7-Br C≡CH 5,7-di-F Et 5-Cl, 7-OMe Cl 5-OCHF.sub.2 C≡CH 5,7-di-Cl Et 5-F, 7-Me Cl 6-OCHF.sub.2 C≡CH 5,7-di-Br Et 5-Me, 7-F Cl 7-OCHF.sub.2 C≡CH — Cl 5-Me, 7-Cl Cl 6,7-di-Me C≡CH 5-Me Cl 5-Me, 7-CN Cl 5,7-di-Me C≡CH 6-Me Cl 5-Me, 7-OMe Cl 5-Cl, 7-Me C≡CH 7-Me Cl 5,7-di-F Cl 5-Cl, 7-OMe C≡CH 5-Et Cl 5,7-di-Cl Cl 5-F, 7-Me C≡CH 6-Et Cl 5,7-di-Br Cl 5-Me, 7-F C≡CH 7-Et Cl — C≡CH 5-Me, 7-Cl C≡CH 5-Pr Cl 5-Me C≡CH 5-Me, 7-CN C≡CH 6-Pr Cl 6-Me C≡CH 5-Me, 7-OMe C≡CH 7-Pr Cl 7-Me C≡CH 5,7-di-F C≡CH 5-OMe Cl 5-Et C≡CH 5,7-di-Cl C≡CH 6-OMe Cl 6-Et C≡CH 5,7-di-Br C≡CH 7-OMe Cl 7-Et C≡CH — SMe 5-CN Cl 5-Pr C≡CH 5-Me SMe 6-CN Cl 6-Pr C≡CH 6-Me SMe 7-CN Cl 7-Pr C≡CH 7-Me SMe 5-CF.sub.3 Cl 5-OMe C≡CH 5-Et SMe 6-CF.sub.3 Cl 6-OMe C≡CH 6-Et SMe 7-CF.sub.3 Cl 7-OMe C≡CH 7-Et SMe 5-F Cl 5-CN C≡CH 5-Pr SMe 6-F Cl 6-CN C≡CH 6-Pr SMe 7-F Cl 7-CN C≡CH 7-Pr SMe 5-Cl Cl 5-CF.sub.3 C≡CH 5-OMe SMe 6-Cl Cl 6-CF.sub.3 C≡CH 6-OMe SMe 7-Cl Cl 7-CF.sub.3 C≡CH 7-OMe SMe 5-Br Cl 5-F C≡CH 5-CN SMe 6-Br Cl 6-F C≡CH 6-CN SMe 7-Br Cl 7-F C≡CH 7-CN SMe 5OCHF.sub.2 Cl 5-Cl C≡CH 5-CF.sub.3 SMe 6-CF.sub.3 SMe 6-Br SMe 5-F, 7-Me SMe 7-CF.sub.3 SMe 7-Br SMe 5-Me, 7-F SMe 5-F SMe 5-OCHF.sub.2 SMe 5-Me, 7-Cl SMe 6-F SMe 6-OCHF.sub.2 SMe 5-Me, 7-CN SMe 7-F SMe 7-OCHF.sub.2 SMe 5-Me, 7-OMe SMe 5-Cl SMe 6,7-di-Me SMe 5,7-di-F SMe 6-Cl SMe 5,7-di-Me SMe 5,7-di-Cl SMe 7-Cl SMe 5-Cl, 7-Me SMe 5,7-di-Br SMe 5-Br SMe 5-Cl, 7-OMe SMe

(15) Table 2 is constructed in the same manner as Table 1 except that the Row Heading “W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L-G is H and” is replaced with the Row Heading listed for Table 2 below (i.e. “W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, and L-G is C(O)Et.”). Therefore the first entry in Table 2 is a compound of Formula 1 wherein W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, (R.sup.3).sub.n is “-” (i.e. n is 0; no substitution with R.sup.3), R.sup.5 is H, R.sup.6 is H, and L-G is C(O)Et. Tables 3 through 959 are constructed similarly.

(16) TABLE-US-00002 Table Row Heading 2 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 3 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 4 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 5 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 6 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 7 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 8 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 9 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 10 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is H, and 11 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 12 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 13 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 14 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 15 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 16 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 17 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 18 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 19 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 20 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is H, and 21 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 22 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 23 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 24 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 25 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 26 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 27 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 28 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 29 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 30 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is H, and 31 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 32 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 33 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 34 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 35 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 36 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 37 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 38 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 39 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 40 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is H, and 41 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 42 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 43 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 44 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 45 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 46 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 47 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 48 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 49 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 50 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is H, and 51 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 52 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 53 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 54 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 55 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 56 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 57 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 58 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 59 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 60 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is H, and 61 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 62 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 63 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 64 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 65 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 66 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 67 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 68 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 69 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 70 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is H, and 71 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 72 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 73 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 74 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 75 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 76 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 77 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 78 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 79 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 80 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is H, and 81 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 82 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 83 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 84 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 85 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 86 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 87 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 88 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 89 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 90 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is H, and 91 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 92 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 93 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 94 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 95 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 96 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 97 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 98 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 99 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 100 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is H, and 101 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 102 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 103 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 104 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 105 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 106 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 107 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 108 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 109 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 110 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is H, and 111 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 112 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 113 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 114 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 115 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 116 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 117 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 118 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 119 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 120 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is H, and 121 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 122 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 123 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 124 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 125 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 126 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 127 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 128 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 129 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 130 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is H, and 131 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 132 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 133 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 134 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 135 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 136 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 137 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 138 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 139 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 140 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is H, and 141 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 142 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 143 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 144 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 145 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 146 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 147 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 148 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 149 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 150 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is H, and 151 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 152 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 153 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 154 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 155 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 156 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 157 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 158 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 159 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 160 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is H, and 161 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 162 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 163 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 164 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 165 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 166 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 167 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 168 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 169 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 170 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is H, and 171 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 172 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 173 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 174 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 175 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 176 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 177 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 178 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 179 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 180 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is H, and 181 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 182 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 183 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 184 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 185 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 186 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 187 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 188 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 189 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 190 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is H, and 191 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 192 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 193 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 194 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 195 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 196 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 197 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 198 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 199 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 200 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is H, and 201 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 202 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 203 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 204 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 205 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 206 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 207 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 208 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 209 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 210 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is H, and 211 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 212 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 213 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 214 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 215 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 216 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 217 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 218 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 219 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 220 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is H, and 221 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 222 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 223 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 224 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 225 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 226 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 227 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 228 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 229 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 230 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is H, and 231 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 232 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 233 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 234 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 235 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 236 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 237 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 238 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 239 W is —C(CH.sub.3).sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 240 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is H, and 241 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 242 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 243 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 244 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 245 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 246 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 247 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 248 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 249 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 250 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is H, and 251 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 252 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 253 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 254 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 255 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 256 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 257 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 258 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 259 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 260 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is H, and 261 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 262 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 263 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 264 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 265 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 266 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 267 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 268 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 269 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 270 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is H, and 271 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 272 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 273 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 274 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 275 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 276 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 277 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 278 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 279 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 280 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is H, and 281 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 282 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 283 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 284 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 285 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 286 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 287 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 288 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 289 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 290 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is H, and 291 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 292 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 293 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 294 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 295 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 296 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 297 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 298 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 299 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 300 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is H, and 301 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 302 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 303 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 304 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 305 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 306 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 307 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 308 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 309 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 310 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is H, and 311 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 312 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 313 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 314 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 315 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 316 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 317 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 318 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 319 W is —C(CH.sub.3).sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 320 W is —O—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is H, and 321 W is —O—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 322 W is —O—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 323 W is —O—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 324 W is —O—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 325 W is —O—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 326 W is —O—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 327 W is —O—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 328 W is —O—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 329 W is —O—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 330 W is —O—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is H, and 331 W is —O—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 332 W is —O—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 333 W is —O—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 334 W is —O—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 335 W is —O—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 336 W is —O—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 337 W is —O—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 338 W is —O—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 339 W is —O—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 340 W is —O—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is H 341 W is —O—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 342 W is —O—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 343 W is —O—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 344 W is —O—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 345 W is —O—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 346 W is —O—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 347 W is —O—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 348 W is —O—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 349 W is —O—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 350 W is —O—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is H, and 351 W is —O—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 352 W is —O—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 353 W is —O—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 354 W is —O—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 355 W is —O—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 356 W is —O—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 357 W is —O—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 358 W is —O—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 359 W is —O—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 360 W is —O—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is H, and 361 W is —O—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 362 W is —O—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 363 W is —O—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 364 W is —O—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 365 W is —O—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 366 W is —O—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 367 W is —O—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 368 W is —O—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 369 W is —O—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 370 W is —O—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is H, and 371 W is —O—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 372 W is —O—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 373 W is —O—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 374 W is —O—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 375 W is —O—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 376 W is —O—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 377 W is —O—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 378 W is —O—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 379 W is —O—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 380 W is —O—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is H, and 381 W is —O—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 382 W is —O—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 383 W is —O—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 384 W is —O—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 385 W is —O—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 386 W is —O—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 387 W is —O—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 388 W is —O—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 389 W is —O—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 390 W is —O—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is H, and 391 W is —O—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 392 W is —O—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 393 W is —O—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 394 W is —O—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 395 W is —O—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 396 W is —O—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 397 W is —O—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 398 W is —O—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 399 W is —O—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 400 W is —O—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is H, and 401 W is —O—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 402 W is —O—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 403 W is —O—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 404 W is —O—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 405 W is —O—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 406 W is —O—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 407 W is —O—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 408 W is —O—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 409 W is —O—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 410 W is —O—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is H, and 411 W is —O—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 412 W is —O—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 413 W is —O—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 414 W is —O—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 415 W is —O—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 416 W is —O—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 417 W is —O—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 418 W is —O—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 419 W is —O—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 420 W is —O—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is H, and 421 W is —O—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 422 W is —O—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 423 W is —O—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 424 W is —O—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 425 W is —O—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 426 W is —O—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 427 W is —O—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 428 W is —O—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 429 W is —O—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 430 W is —O—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is H, and 431 W is —O—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 432 W is —O—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 433 W is —O—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 434 W is —O—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 435 W is —O—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 436 W is —O—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 437 W is —O—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 438 W is —O—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 439 W is —O—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 440 W is —O—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is H, and 441 W is —O—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 442 W is —O—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 443 W is —O—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 444 W is —O—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 445 W is —O—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 446 W is —O—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 447 W is —O—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 448 W is —O—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 449 W is —O—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 450 W is —O—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is H, and 451 W is —O—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 452 W is —O—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 453 W is —O—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 454 W is —O—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 455 W is —O—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 456 W is —O—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 457 W is —O—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 458 W is —O—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 459 W is —O—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 460 W is —O—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is H, and 461 W is —O—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 462 W is —O—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 463 W is —O—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 464 W is —O—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 465 W is —O—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 466 W is —O—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 467 W is —O—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 468 W is —O—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 469 W is —O—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 470 W is —O—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is H, and 471 W is —O—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 472 W is —O—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 473 W is —O—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 474 W is —O—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 475 W is —O—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 476 W is —O—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 477 W is —O—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 478 W is —O—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 479 W is —O—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 480 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is H, and 481 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 482 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 483 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 484 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 485 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 486 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 487 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 488 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 489 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 490 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is H, and 491 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 492 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 493 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 494 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 495 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 496 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 497 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 498 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 499 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 500 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is H, and 501 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 502 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 503 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 504 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 505 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 506 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 507 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 508 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 509 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 510 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is H, and 511 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 512 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 513 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 514 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 515 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 516 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 517 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 518 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 519 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 520 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is H, and 521 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 522 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 523 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 524 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 525 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 526 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 527 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 528 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 529 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 530 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is H, and 531 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 532 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 533 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 534 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 535 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 536 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 537 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 538 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 539 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 540 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is H, and 541 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 542 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 543 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 544 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 545 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 546 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 547 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 548 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 549 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 550 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is H, and 551 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 552 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 553 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 554 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 555 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 556 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 557 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 558 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 559 W is —CH(CH.sub.3)—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 560 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is H, and 561 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 562 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 563 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 564 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 565 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 566 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 567 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 568 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 569 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 570 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is H, and 571 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 572 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 573 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 574 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 575 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 576 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 577 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 578 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 579 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 580 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is H, and 581 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 582 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 583 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 584 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 585 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 586 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 587 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 588 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 589 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 590 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is H, and 591 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 592 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 593 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 594 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 595 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 596 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 597 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 598 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 599 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 600 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is H, and 601 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 602 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 603 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 604 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 605 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 606 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 607 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 608 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 609 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 610 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is H, and 611 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 612 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 613 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 614 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 615 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 616 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 617 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 618 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 619 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 620 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is H, and 621 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 622 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 623 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 624 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 625 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 626 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 627 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 628 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 629 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 630 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is H, and 631 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Me, and 632 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)Et, and 633 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—i-Pr, and 634 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is C(O)—t-Bu, and 635 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Me, and 636 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2Et, and 637 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 638 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 639 W is —CH(CH.sub.3)—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is H, R.sup.6 is H, L—G is SO.sub.2Me, and 640 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is H, and 641 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Me, and 642 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Et, and 643 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—i-Pr, and 644 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—t-Bu, and 645 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Me, and 646 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Et, and 647 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 648 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 649 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is SO.sub.2Me, and 650 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is H, and 651 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Me, and 652 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Et, and 653 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—i-Pr, and 654 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—t-Bu, and 655 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Me, and 656 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Et, and 657 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 658 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 659 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is SO.sub.2Me, and 660 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is H, and 661 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Me, and 662 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Et, and 663 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—i-Pr, and 664 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—t-Bu, and 665 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Me, and 666 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Et, and 667 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 668 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 669 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is SO.sub.2Me, and 670 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is H, and 671 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Me, and 672 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Et, and 673 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—i-Pr, and 674 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—t-Bu, and 675 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Me, and 676 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Et, and 677 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 678 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 679 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is SO.sub.2Me, and 680 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is H, and 681 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Me, and 682 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Et, and 683 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—i-Pr, and 684 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—t-Bu, and 685 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Me, and 686 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Et, and 687 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 688 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 689 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is SO.sub.2Me, and 690 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is H, and 691 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Me, and 692 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Et, and 693 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—i-Pr, and 694 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—t-Bu, and 695 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Me, and 696 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Et, and 697 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 698 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 699 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is SO.sub.2Me, and 700 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is H, and 701 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Me, and 702 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Et, and 703 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—i-Pr, and 704 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—t-Bu, and 705 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Me, and 706 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Et, and 707 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 708 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 709 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is SO.sub.2Me, and 710 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is H, and 711 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Me, and 712 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Et, and 713 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—i-Pr, and 714 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—t-Bu, and 715 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Me, and 716 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Et, and 717 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 718 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 719 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is SO.sub.2Me, and 720 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is H, and 721 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Me, and 722 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Et, and 723 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—i-Pr, and 724 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—t-Bu, and 725 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Me, and 726 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Et, and 727 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 728 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 729 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is SO.sub.2Me, and 730 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is H, and 731 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Me, and 732 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Et, and 733 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—i-Pr, and 734 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—t-Bu, and 735 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Me, and 736 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Et, and 737 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 738 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 739 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is SO.sub.2Me, and 740 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is H, and 741 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Me, and 742 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Et, and 743 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—i-Pr, and 744 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—t-Bu, and 745 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Me, and 746 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Et, and 747 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 748 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 749 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is SO.sub.2Me, and 750 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is H, and 751 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Me, and 752 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Et, and 753 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—i-Pr, and 754 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—t-Bu, and 755 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Me, and 756 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Et, and 757 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 758 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 759 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is SO.sub.2Me, and 760 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is H, and 761 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Me, and 762 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Et, and 763 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—i-Pr, and 764 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—t-Bu, and 765 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Me, and 766 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Et, and 767 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 768 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 769 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is SO.sub.2Me, and 770 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is H, and 771 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Me, and 772 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Et, and 773 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—i-Pr, and 774 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—t-Bu, and 775 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Me, and 776 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Et, and 777 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 778 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 779 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is SO.sub.2Me, and 780 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is H, and 781 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Me, and 782 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Et, and 783 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—i-Pr, and 784 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—t-Bu, and 785 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Me, and 786 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Et, and 787 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 788 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 789 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is SO.sub.2Me, and 790 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is H, and 791 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Me, and 792 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)Et, and 793 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—i-Pr, and 794 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is C(O)—t-Bu, and 795 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Me, and 796 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2Et, and 797 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—i-Pr, and 798 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is CO.sub.2—t-Bu, and 799 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 is H, L—G is SO.sub.2Me, and 800 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is H, and 801 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Me, and 802 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Et, and 803 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—i-Pr, and 804 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—t-Bu, and 805 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Me, and 806 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Et, and 807 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—i-Pr, and 808 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—t-Bu, and 809 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is SO.sub.2Me, and 810 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is H, and 811 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Me, and 812 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Et, and 813 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—i-Pr, and 814 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—t-Bu, and 815 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Me, and 816 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Et, and 817 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—i-Pr, and 818 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—t-Bu, and 819 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is SO.sub.2Me, and 820 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is H, and 821 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Me, and 822 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Et, and 823 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—i-Pr, and 824 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—t-Bu, and 825 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Me, and 826 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Et, and 827 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—i-Pr, and 828 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—t-Bu, and 829 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is SO.sub.2Me, and 830 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is H, and 831 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Me, and 832 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Et, and 833 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—i-Pr, and 834 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—t-Bu, and 835 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Me, and 836 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Et, and 837 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—i-Pr, and 838 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—t-Bu, and 839 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is SO.sub.2Me, and 840 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is H, and 841 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Me, and 842 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Et, and 843 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—i-Pr, and 844 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—t-Bu, and 845 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Me, and 846 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Et, and 847 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—i-Pr, and 848 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—t-Bu, and 849 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is SO.sub.2Me, and 850 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is H, and 851 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Me, and 852 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Et, and 853 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—i-Pr, and 854 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—t-Bu, and 855 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Me, and 856 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Et, and 857 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—i-Pr, and 858 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—t-Bu, and 859 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is SO.sub.2Me, and 860 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is H, and 861 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Me, and 862 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Et, and 863 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—i-Pr, and 864 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—t-Bu, and 865 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Me, and 866 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Et, and 867 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—i-Pr, and 868 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—t-Bu, and 869 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is SO.sub.2Me, and 870 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is H, and 871 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Me, and 872 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Et, and 873 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—i-Pr, and 874 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—t-Bu, and 875 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Me, and 876 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Et, and 877 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—i-Pr, and 878 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—t-Bu, and 879 W is —CH.sub.2—, R.sup.1 is Me, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is SO.sub.2Me, and 880 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is H, and 881 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Me, and 882 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Et, and 883 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—i-Pr, and 884 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—t-Bu, and 885 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Me, and 886 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Et, and 887 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—i-Pr, and 888 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—t-Bu, and 889 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Me, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is SO.sub.2Me, and 890 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is H, and 891 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Me, and 892 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Et, and 893 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—i-Pr, and 894 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—t-Bu, and 895 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Me, and 896 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Et, and 897 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—i-Pr, and 898 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—t-Bu, and 899 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is H, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is SO.sub.2Me, and 900 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is H, and 901 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Me, and 902 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Et, and 903 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—i-Pr, and 904 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—t-Bu, and 905 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Me, and 906 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Et, and 907 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—i-Pr, and 908 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—t-Bu, and 909 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CF.sub.3, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is SO.sub.2Me, and 910 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is H, and 911 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Me, and 912 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Et, and 913 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—i-Pr, and 914 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—t-Bu, and 915 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Me, and 916 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Et, and 917 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—i-Pr, and 918 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—t-Bu, and 919 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Cl, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is SO.sub.2Me, and 920 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is H, and 921 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Me, and 922 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Et, and 923 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—i-Pr, and 924 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—t-Bu, and 925 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Me, and 926 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Et, and 927 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—i-Pr, and 928 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—t-Bu, and 929 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is Br, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is SO.sub.2Me, and 930 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is H, and 931 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Me, and 932 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Et, and 933 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—i-Pr, and 934 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—t-Bu, and 935 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Me, and 936 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Et, and 937 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—i-Pr, and 938 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—t-Bu, and 939 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is I, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is SO.sub.2Me, and 940 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is H, and 941 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Me, and 942 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Et, and 943 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—i-Pr, and 944 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—t-Bu, and 945 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Me, and 946 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Et, and 947 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—i-Pr, and 948 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—t-Bu, and 949 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is OMe, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is SO.sub.2Me, and 950 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is H, and 951 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Me, and 952 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)Et, and 953 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—i-Pr, and 954 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is C(O)—t-Bu, and 955 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Me, and 956 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2Et, and 957 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—i-Pr, and 958 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is CO.sub.2—t-Bu, and 959 W is —CH.sub.2—, R.sup.1 is Et, R.sup.2 is CN, R.sup.5 is CH.sub.3, R.sup.6 CH.sub.3, L—G is SO.sub.2Me, and

(17) A compound of this invention will generally be used as a herbicidal active ingredient in a composition, i.e. formulation, with at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents, which serves as a carrier. The formulation or composition ingredients are selected to be consistent with the physical properties of the active ingredient, mode of application and environmental factors such as soil type, moisture and temperature.

(18) Useful formulations include both liquid and solid compositions. Liquid compositions include solutions (including emulsifiable concentrates), suspensions, emulsions (including microemulsions, oil-in-water emulsions, flowable concentrates and/or suspoemulsions) and the like, which optionally can be thickened into gels. The general types of aqueous liquid compositions are soluble concentrate, suspension concentrate, capsule suspension, concentrated emulsion, microemulsion, oil-in-water emulsion, flowable concentrate and suspo-emulsion. The general types of nonaqueous liquid compositions are emulsifiable concentrate, microemulsifiable concentrate, dispersible concentrate and oil dispersion.

(19) The general types of solid compositions are dusts, powders, granules, pellets, prills, pastilles, tablets, filled films (including seed coatings) and the like, which can be water-dispersible (“wettable”) or water-soluble. Films and coatings formed from film-forming solutions or flowable suspensions are particularly useful for seed treatment. Active ingredient can be (micro)encapsulated and further formed into a suspension or solid formulation; alternatively the entire formulation of active ingredient can be encapsulated (or “overcoated”). Encapsulation can control or delay release of the active ingredient. An emulsifiable granule combines the advantages of both an emulsifiable concentrate formulation and a dry granular formulation. High-strength compositions are primarily used as intermediates for further formulation.

(20) Sprayable formulations are typically extended in a suitable medium before spraying. Such liquid and solid formulations are formulated to be readily diluted in the spray medium, usually water, but occasionally another suitable medium like an aromatic or paraffinic hydrocarbon or vegetable oil. Spray volumes can range from about from about one to several thousand liters per hectare, but more typically are in the range from about ten to several hundred liters per hectare. Sprayable formulations can be tank mixed with water or another suitable medium for foliar treatment by aerial or ground application, or for application to the growing medium of the plant. Liquid and dry formulations can be metered directly into drip irrigation systems or metered into the furrow during planting.

(21) The formulations will typically contain effective amounts of active ingredient, diluent and surfactant within the following approximate ranges which add up to 100 percent by weight.

(22) TABLE-US-00003 Weight Percent Active Ingredient Diluent Surfactant Water-Dispersible and Water- 0.001-90 0-99.999 0-15 soluble Granules, Tablets and Powders Oil Dispersions, Suspensions,    1-50 40-99    0-50 Emulsions, Solutions (including Emulsifiable Concentrates) Dusts    1-25 70-99    0-5  Granules and Pellets 0.001-99 5-99.999 0-15 High Strength Compositions   90-99 0-10    0-2 

(23) Solid diluents include, for example, clays such as bentonite, montmorillonite, attapulgite and kaolin, gypsum, cellulose, titanium dioxide, zinc oxide, starch, dextrin, sugars (e.g., lactose, sucrose), silica, talc, mica, diatomaceous earth, urea, calcium carbonate, sodium carbonate and bicarbonate, and sodium sulfate. Typical solid diluents are described in Watkins et al., Handbook of Insecticide Dust Diluents and Carriers, 2nd Ed., Dorland Books, Caldwell, N.J.

(24) Liquid diluents include, for example, water, N,N-dimethylalkanamides (e.g., N,N-dimethylformamide), limonene, dimethyl sulfoxide, N-alkylpyrrolidones (e.g., N-methylpyrrolidinone), alkyl phosphates (e.g., triethyl phosphate), ethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, propylene carbonate, butylene carbonate, paraffins (e.g., white mineral oils, normal paraffins, isoparaffins), alkylbenzenes, alkylnaphthalenes, glycerine, glycerol triacetate, sorbitol, aromatic hydrocarbons, dearomatized aliphatics, alkylbenzenes, alkylnaphthalenes, ketones such as cyclohexanone, 2-heptanone, isophorone and 4-hydroxy-4-methyl-2-pentanone, acetates such as isoamyl acetate, hexyl acetate, heptyl acetate, octyl acetate, nonyl acetate, tridecyl acetate and isobornyl acetate, other esters such as alkylated lactate esters, dibasic esters, alkyl and aryl benzoates and γ-butyrolactone, and alcohols, which can be linear, branched, saturated or unsaturated, such as methanol, ethanol, n-propanol, isopropyl alcohol, n-butanol, isobutyl alcohol, n-hexanol, 2-ethylhexanol, n-octanol, decanol, isodecyl alcohol, isooctadecanol, cetyl alcohol, lauryl alcohol, tridecyl alcohol, oleyl alcohol, cyclohexanol, tetrahydrofurfuryl alcohol, diacetone alcohol, cresol and benzyl alcohol. Liquid diluents also include glycerol esters of saturated and unsaturated fatty acids (typically C.sub.6-C.sub.22), such as plant seed and fruit oils (e.g., oils of olive, castor, linseed, sesame, corn (maize), peanut, sunflower, grapeseed, safflower, cottonseed, soybean, rapeseed, coconut and palm kernel), animal-sourced fats (e.g., beef tallow, pork tallow, lard, cod liver oil, fish oil), and mixtures thereof. Liquid diluents also include alkylated fatty acids (e.g., methylated, ethylated, butylated) wherein the fatty acids may be obtained by hydrolysis of glycerol esters from plant and animal sources, and can be purified by distillation. Typical liquid diluents are described in Marsden, Solvents Guide, 2nd Ed., Interscience, New York, 1950.

(25) The solid and liquid compositions of the present invention often include one or more surfactants. When added to a liquid, surfactants (also known as “surface-active agents”) generally modify, most often reduce, the surface tension of the liquid. Depending on the nature of the hydrophilic and lipophilic groups in a surfactant molecule, surfactants can be useful as wetting agents, dispersants, emulsifiers or defoaming agents.

(26) Surfactants can be classified as nonionic, anionic or cationic. Nonionic surfactants useful for the present compositions include, but are not limited to: alcohol alkoxylates such as alcohol alkoxylates based on natural and synthetic alcohols (which may be branched or linear) and prepared from the alcohols and ethylene oxide, propylene oxide, butylene oxide or mixtures thereof; amine ethoxylates, alkanolamides and ethoxylated alkanolamides; alkoxylated triglycerides such as ethoxylated soybean, castor and rapeseed oils; alkylphenol alkoxylates such as octylphenol ethoxylates, nonylphenol ethoxylates, dinonyl phenol ethoxylates and dodecyl phenol ethoxylates (prepared from the phenols and ethylene oxide, propylene oxide, butylene oxide or mixtures thereof); block polymers prepared from ethylene oxide or propylene oxide and reverse block polymers where the terminal blocks are prepared from propylene oxide; ethoxylated fatty acids; ethoxylated fatty esters and oils; ethoxylated methyl esters; ethoxylated tristyrylphenol (including those prepared from ethylene oxide, propylene oxide, butylene oxide or mixtures thereof); fatty acid esters, glycerol esters, lanolin-based derivatives, polyethoxylate esters such as polyethoxylated sorbitan fatty acid esters, polyethoxylated sorbitol fatty acid esters and polyethoxylated glycerol fatty acid esters; other sorbitan derivatives such as sorbitan esters; polymeric surfactants such as random copolymers, block copolymers, alkyd peg (polyethylene glycol) resins, graft or comb polymers and star polymers; polyethylene glycols (pegs); polyethylene glycol fatty acid esters; silicone-based surfactants; and sugar-derivatives such as sucrose esters, alkyl polyglycosides and alkyl polysaccharides.

(27) Useful anionic surfactants include, but are not limited to: alkylaryl sulfonic acids and their salts; carboxylated alcohol or alkylphenol ethoxylates; diphenyl sulfonate derivatives; lignin and lignin derivatives such as lignosulfonates; maleic or succinic acids or their anhydrides; olefin sulfonates; phosphate esters such as phosphate esters of alcohol alkoxylates, phosphate esters of alkylphenol alkoxylates and phosphate esters of styryl phenol ethoxylates; protein-based surfactants; sarcosine derivatives; styryl phenol ether sulfate; sulfates and sulfonates of oils and fatty acids; sulfates and sulfonates of ethoxylated alkylphenols; sulfates of alcohols; sulfates of ethoxylated alcohols; sulfonates of amines and amides such as N,N-alkyltaurates; sulfonates of benzene, cumene, toluene, xylene, and dodecyl and tridecylbenzenes; sulfonates of condensed naphthalenes; sulfonates of naphthalene and alkyl naphthalene; sulfonates of fractionated petroleum; sulfosuccinamates; and sulfosuccinates and their derivatives such as dialkyl sulfosuccinate salts.

(28) Useful cationic surfactants include, but are not limited to: amides and ethoxylated amides; amines such as N-alkyl propanediamines, tripropylenetriamines and dipropylenetetramines, and ethoxylated amines, ethoxylated diamines and propoxylated amines (prepared from the amines and ethylene oxide, propylene oxide, butylene oxide or mixtures thereof); amine salts such as amine acetates and diamine salts; quaternary ammonium salts such as quaternary salts, ethoxylated quaternary salts and diquaternary salts; and amine oxides such as alkyldimethylamine oxides and bis-(2-hydroxyethyl)-alkylamine oxides.

(29) Also useful for the present compositions are mixtures of nonionic and anionic surfactants or mixtures of nonionic and cationic surfactants. Nonionic, anionic and cationic surfactants and their recommended uses are disclosed in a variety of published references including McCutcheon's Emulsifiers and Detergents, annual American and International Editions published by McCutcheon's Division, The Manufacturing Confectioner Publishing Co.; Sisely and Wood, Encyclopedia of Surface Active Agents, Chemical Publ. Co., Inc., New York, 1964; and A. S. Davidson and B. Milwidsky, Synthetic Detergents, Seventh Edition, John Wiley and Sons, New York, 1987.

(30) Compositions of this invention may also contain formulation auxiliaries and additives, known to those skilled in the art as formulation aids (some of which may be considered to also function as solid diluents, liquid diluents or surfactants). Such formulation auxiliaries and additives may control: pH (buffers), foaming during processing (antifoams such polyorganosiloxanes), sedimentation of active ingredients (suspending agents), viscosity (thixotropic thickeners), in-container microbial growth (antimicrobials), product freezing (antifreezes), color (dyes/pigment dispersions), wash-off (film formers or stickers), evaporation (evaporation retardants), and other formulation attributes. Film formers include, for example, polyvinyl acetates, polyvinyl acetate copolymers, polyvinylpyrrolidone-vinyl acetate copolymer, polyvinyl alcohols, polyvinyl alcohol copolymers and waxes. Examples of formulation auxiliaries and additives include those listed in McCutcheon's Volume 2: Functional Materials, annual International and North American editions published by McCutcheon's Division, The Manufacturing Confectioner Publishing Co.; and PCT Publication WO 03/024222.

(31) The compound of Formula 1 and any other active ingredients are typically incorporated into the present compositions by dissolving the active ingredient in a solvent or by grinding in a liquid or dry diluent. Solutions, including emulsifiable concentrates, can be prepared by simply mixing the ingredients. If the solvent of a liquid composition intended for use as an emulsifiable concentrate is water-immiscible, an emulsifier is typically added to emulsify the active-containing solvent upon dilution with water. Active ingredient slurries, with particle diameters of up to 2,000 μm can be wet milled using media mills to obtain particles with average diameters below 3 μm. Aqueous slurries can be made into finished suspension concentrates (see, for example, U.S. Pat. No. 3,060,084) or further processed by spray drying to form water-dispersible granules. Dry formulations usually require dry milling processes, which produce average particle diameters in the 2 to 10 μm range. Dusts and powders can be prepared by blending and usually grinding (such as with a hammer mill or fluid-energy mill). Granules and pellets can be prepared by spraying the active material upon preformed granular carriers or by agglomeration techniques. See Browning, “Agglomeration”, Chemical Engineering, Dec. 4, 1967, pp 147-48, Perry's Chemical Engineer's Handbook, 4th Ed., McGraw-Hill, New York, 1963, pages 8-57 and following, and WO 91/13546. Pellets can be prepared as described in U.S. Pat. No. 4,172,714. Water-dispersible and water-soluble granules can be prepared as taught in U.S. Pat. Nos. 4,144,050, 3,920,442 and DE 3,246,493. Tablets can be prepared as taught in U.S. Pat. Nos. 5,180,587, 5,232,701 and 5,208,030. Films can be prepared as taught in GB 2,095,558 and U.S. Pat. No. 3,299,566.

(32) For further information regarding the art of formulation, see T. S. Woods, “The Formulator's Toolbox—Product Forms for Modern Agriculture” in Pesticide Chemistry and Bioscience, The Food-Environment Challenge, T. Brooks and T. R. Roberts, Eds., Proceedings of the 9th International Congress on Pesticide Chemistry, The Royal Society of Chemistry, Cambridge, 1999, pp. 120-133. See also U.S. Pat. No. 3,235,361, Col. 6, line 16 through Col. 7, line 19 and Examples 10-41; U.S. Pat. No. 3,309,192, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182; U.S. Pat. No. 2,891,855, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4; Klingman, Weed Control as a Science, John Wiley and Sons, Inc., New York, 1961, pp 81-96; Hance et al., Weed Control Handbook, 8th Ed., Blackwell Scientific Publications, Oxford, 1989; and Developments in formulation technology, PJB Publications, Richmond, U K, 2000.

(33) In the following Examples, all percentages are by weight and all formulations are prepared in conventional ways. Compound numbers refer to compounds in Index Table A. Without further elaboration, it is believed that one skilled in the art using the preceding description can utilize the present invention to its fullest extent. The following Examples are, therefore, to be construed as merely illustrative, and not limiting of the disclosure in any way whatsoever. Percentages are by weight except where otherwise indicated.

EXAMPLE A

(34) High Strength Concentrate

(35) TABLE-US-00004 Compound 1 98.5% silica aerogel 0.5% synthetic amorphous fine silica 1.0%

EXAMPLE B

(36) Wettable Powder

(37) TABLE-US-00005 Compound 1 65.0% dodecylphenol polyethylene glycol ether 2.0% sodium ligninsulfonate 4.0% sodium silicoaluminate 6.0% montmorillonite (calcined) 23.0%

EXAMPLE C

(38) Granule

(39) TABLE-US-00006 Compound 1 10.0% attapulgite granules (low volatile matter, 0.71/0.30 mm; 90.0% U.S.S. No. 25-50 sieves)

EXAMPLE D

(40) Extruded Pellet

(41) TABLE-US-00007 Compound 1 25.0% anhydrous sodium sulfate 10.0% crude calcium ligninsulfonate 5.0% sodium alkylnaphthalenesulfonate 1.0% calcium/magnesium bentonite 59.0%

EXAMPLE E

(42) Emulsifiable Concentrate

(43) TABLE-US-00008 Compound 1 10.0% polyoxyethylene sorbitol hexoleate 20.0% C.sub.6-C.sub.10 fatty acid methyl ester 70.0%

EXAMPLE F

(44) Microemulsion

(45) TABLE-US-00009 Compound 1 5.0% polyvinylpyrrolidone-vinyl acetate copolymer 30.0% alkylpolyglycoside 30.0% glyceryl monooleate 15.0% water 20.0%

EXAMPLE G

(46) Suspension Concentrate

(47) TABLE-US-00010 Compound 1  35% butyl polyoxyethylene/polypropylene block copolymer 4.0% stearic acid/polyethylene glycol copolymer 1.0% styrene acrylic polymer 1.0% xanthan gum 0.1% propylene glycol 5.0% silicone based defoamer 0.1% 1,2-benzisothiazolin-3-one 0.1% water 53.7% 

EXAMPLE H

(48) Emulsion in Water

(49) TABLE-US-00011 Compound 1 10.0% butyl polyoxyethylene/polypropylene block copolymer 4.0% stearic acid/polyethylene glycol copolymer 1.0% styrene acrylic polymer 1.0% xanthan gum 0.1% propylene glycol 5.0% silicone based defoamer 0.1% 1,2-benzisothiazolin-3-one 0.1% aromatic petroleum based hydrocarbon 20.0 water 58.7%

EXAMPLE I

(50) Oil Dispersion

(51) TABLE-US-00012 Compound 1 25% polyoxyethylene sorbitol hexaoleate 15% organically modified bentonite clay 2.5%  fatty acid methyl ester 57.5%  

(52) The present disclosure also includes Examples A through I above except “Compound 1” is replaced with “Compound 2” and “Compound 3”. “Compound 4”, “Compound 5”, “Compound 6”, Compound 7” or “Compound 8” above as described in Index Table A. Test results indicate that the compounds of the present invention are highly active preemergent and/or postemergent herbicides and/or plant growth regulants. The compounds of the invention generally show highest activity for postemergence weed control (i.e. applied after weed seedlings emerge from the soil) and preemergence weed control (i.e. applied before weed seedlings emerge from the soil). Many of them have utility for broad-spectrum pre- and/or postemergence weed control in areas where complete control of all vegetation is desired such as around fuel storage tanks, industrial storage areas, parking lots, drive-in theaters, air fields, river banks, irrigation and other waterways, around billboards and highway and railroad structures. Many of the compounds of this invention, by virtue of selective metabolism in crops versus weeds, or by selective activity at the locus of physiological inhibition in crops and weeds, or by selective placement on or within the environment of a mixture of crops and weeds, are useful for the selective control of grass and broadleaf weeds within a crop/weed mixture. One skilled in the art will recognize that the preferred combination of these selectivity factors within a compound or group of compounds can readily be determined by performing routine biological and/or biochemical assays. Compounds of this invention may show tolerance to important agronomic crops including, but is not limited to, alfalfa, barley, cotton, wheat, rape, sugar beets, corn (maize), sorghum, soybeans, rice, oats, peanuts, vegetables, tomato, potato, perennial plantation crops including coffee, cocoa, oil palm, rubber, sugarcane, citrus, grapes, fruit trees, nut trees, banana, plantain, pineapple, hops, tea and forests such as eucalyptus and conifers (e.g., loblolly pine), and turf species (e.g., Kentucky bluegrass, St. Augustine grass, Kentucky fescue and Bermuda grass). Compounds of this invention can be used in crops genetically transformed or bred to incorporate resistance to herbicides, express proteins toxic to invertebrate pests (such as Bacillus thuringiensis toxin), and/or express other useful traits. Those skilled in the art will appreciate that not all compounds are equally effective against all weeds. Alternatively, the subject compounds are useful to modify plant growth.

(53) As the compounds of the invention have both preemergent and postemergent herbicidal activity, to control undesired vegetation by killing or injuring the vegetation or reducing its growth, the compounds can be usefully applied by a variety of methods involving contacting a herbicidally effective amount of a compound of the invention, or a composition comprising said compound and at least one of a surfactant, a solid diluent or a liquid diluent, to the foliage or other part of the undesired vegetation or to the environment of the undesired vegetation such as the soil or water in which the undesired vegetation is growing or which surrounds the seed or other propagule of the undesired vegetation. Undesired vegetation includes at least one selected from the group consisting of grass weeds and broadleaf weeds. Undesired vegetation is selected from the group consisting of annual bluegrass (Poa annua), Benghal dayflower, blackgrass (Alopecurus myosuroides), black nightshade (eastern black nightshade, Solanum ptycanthum), broadleaf signalgrass, Canada thistle, cheat, common cocklebur (Xanthium pensylvanicum or Xanthium strumarium), corn poppies, field violet (Viola arvensis), goosegrass (Eleusine indica), guinea grass, hairy beggarticks (Bidens pilosa), herbicide-resistant blackgrass, horseweed, Italian rye grass, jimsonweed, Johnson grass (Sorghum halepense), large crabgrass (Digitaria sanguinalis), little seed canary grass, morning glory, Pennsylvania smartweed, ladysthumb smartweed (Polygonum Persicaria), pitted morning glory, prickly sida, quackgrass, redroot pigweed, palmer pigweed (Amaranthus palmeri), shattercane, shepherd's purse, windgrass, silky windgrass (Apera spica-venti), sunflower (Helianthus annuus, as a weed in a potato crop), wild buckwheat (Polygonum convolvulus), wild mustard (Sinapis arvensis), wild oat (Avena fatua), wild pointsettia, yellow foxtail, yellow nutsedge (Cyperus esculentus), johnsongrass (Sorghum halepense), lambsquarters (Chenopodium album), morningglory (Ipomoea coccinea), common waterhemp (Amaranthus rudis), surinam grass (Brachiaria decumbens), downy bromegrass (Bromus tectorum), woolly cupgrass (Eriochloa villosa), bermudagrass (Cynodon dactylon), Russian thistle (Salsola kali), velvetleaf (Abutilon theophrasti), common chickweed (Stellaria media), henbit deadnettle (Lamium amplexicaule), littleseed canarygrass (Phalaris minor), field poppy (Papaver rhoeas), scentless chamomile (Matricaria inodora), bird's-eye speedwell (Veronica persica), wild radish (Raphanus raphanistrum), wild poinsettia (Euphorbia heterophylla), Brazilian crabgrass (Digitaria horizontalis), fall panicum (Panicum dichotomiflorum), southern sandbur (Cenchrus echinatus), arrowleaf sida (Sida rhombifolia), Virginia dayflower (Commelina virginica), field bindweed (Convolvulus arvensis), monochoria (Monochoria vaginalis), hardstem bulrush (Scirpus juncoides), purple redstem (Ammannia coccinea), bearded sprangletop (Leptochloa fascicularis), common waterplantain (Alisma plantago-aquatica), and late watergrass (Echinochloa oryzicola).

(54) A herbicidally effective amount of the compounds of this invention is determined by a number of factors. These factors include: formulation selected, method of application, amount and type of vegetation present, growing conditions, etc. In general, a herbicidally effective amount of compounds of this invention is about 0.001 to 20 kg/ha with a preferred range of about 0.004 to 1 kg/ha. One skilled in the art can easily determine the herbicidally effective amount necessary for the desired level of weed control.

(55) In one common embodiment, a compound of the invention is applied, typically in a formulated composition, to a locus comprising desired vegetation (e.g., crops) and undesired vegetation (i.e. weeds), both of which may be seeds, seedlings and/or larger plants, in contact with a growth medium (e.g., soil). In this locus, a composition comprising a compound of the invention can be directly applied to a plant or a part thereof, particularly of the undesired vegetation, and/or to the growth medium in contact with the plant.

(56) Plant varieties and cultivars of the desired vegetation in the locus treated with a compound of the invention can be obtained by conventional propagation and breeding methods or by genetic engineering methods. Genetically modified plants (transgenic plants) are those in which a heterologous gene (transgene) has been stably integrated into the plant's genome. A transgene that is defined by its particular location in the plant genome is called a transformation or transgenic event.

(57) Although most typically, compounds of the invention are used to control undesired vegetation, contact of desired vegetation in the treated locus with compounds of the invention may result in super-additive or synergistic (enhanced) effects with genetic traits in the desired vegetation, including traits incorporated through genetic modification. For example, resistance to phytophagous insect pests or plant diseases, tolerance to biotic/abiotic stresses or storage stability may be greater than expected from the genetic traits in the desired vegetation.

(58) Compounds of this invention can also be mixed with one or more other biologically active compounds or agents including herbicides, herbicide safeners, fungicides, insecticides, nematocides, bactericides, acaricides, growth regulators such as insect molting inhibitors and rooting stimulants, chemosterilants, semiochemicals, repellents, attractants, pheromones, feeding stimulants, plant nutrients, other biologically active compounds or entomopathogenic bacteria, virus or fungi to form a multi-component pesticide giving an even broader spectrum of agricultural protection. Mixtures of the compounds of the invention with other herbicides can broaden the spectrum of activity against additional weed species, and suppress the proliferation of any resistant biotypes. Thus the present invention also pertains to a composition comprising a compound of Formula 1 (in a herbicidally effective amount) and at least one additional biologically active compound or agent (in a biologically effective amount) and can further comprise at least one of a surfactant, a solid diluent or a liquid diluent. The other biologically active compounds or agents can be formulated in compositions comprising at least one of a surfactant, solid or liquid diluent.

(59) For mixtures of the present invention, one or more other biologically active compounds or agents can be formulated together with a compound of Formula 1, to form a premix, or one or more other biologically active compounds or agents can be formulated separately from the compound of Formula 1, and the formulations combined together before application (e.g., in a spray tank) or, alternatively, applied in succession.

(60) A mixture of one or more of the following herbicides with a compound of this invention may be particularly useful for weed control: acetochlor, acifluorfen and its sodium salt, aclonifen, acrolein (2-propenal), alachlor, alloxydim, ametryn, amicarbazone, amidosulfuron, aminocyclopyrachlor and its esters (e.g., methyl, ethyl) and salts (e.g., sodium, potassium), aminopyralid, amitrole, ammonium sulfamate, anilofos, asulam, atrazine, azimsulfuron, beflubutamid, S-beflubutamide, benazolin, benazolin-ethyl, bencarbazone, benfluralin, benfuresate, bensulfuron-methyl, bensulide, bentazone, benzobicyclon, benzofenap, bicyclopyrone, bifenox, bilanafos, bispyribac and its sodium salt, bromacil, bromobutide, bromofenoxim, bromoxynil, bromoxynil octanoate, butachlor, butafenacil, butamifos, butralin, butroxydim, butylate, cafenstrole, carbetamide, carfentrazone-ethyl, catechin, chlomethoxyfen, chloramben, chlorbromuron, chlorflurenol-methyl, chloridazon, chlorimuron-ethyl, chlorotoluron, chlorpropham, chlorsulfuron, chlorthal-dimethyl, chlorthiamid, cinidon-ethyl, cinmethylin, cinosulfuron, clacyfos, clefoxydim, clethodim, clodinafop-propargyl, clomazone, clomeprop, clopyralid, clopyralid-olamine, cloransulam-methyl, cumyluron, cyanazine, cycloate, cyclopyranil, cyclopyrimorate, cyclosulfamuron, cycloxydim, cyhalofop-butyl, 2,4-D and its butotyl, butyl, isoctyl and isopropyl esters and its dimethylammonium, diolamine and trolamine salts, daimuron, dalapon, dalapon-sodium, dazomet, 2,4-DB and its dimethylammonium, potassium and sodium salts, desmedipham, desmetryn, dicamba and its diglycolammonium, dimethylammonium, potassium and sodium salts, dichlobenil, dichlorprop, diclofop-methyl, diclosulam, difenzoquat metilsulfate, diflufenican, diflufenzopyr, dimefuron, dimepiperate, dimethachlor, dimethametryn, dimethenamid, dimethenamid-P, dimethipin, dimethylarsinic acid and its sodium salt, dinitramine, dinoterb, diphenamid, diquat dibromide, dithiopyr, diuron, DNOC, endothal, EPTC, esprocarb, ethalfluralin, ethametsulfuron-methyl, ethiozin, ethofumesate, ethoxyfen, ethoxysulfuron, etobenzanid, fenoxaprop-ethyl, fenoxaprop-P-ethyl, fenoxasulfone, fenquinotrione, fentrazamide, fenuron, fenuron-TCA, flamprop-methyl, flamprop-M-isopropyl, flamprop-M-methyl, flazasulfuron, florasulam, fluazifop-butyl, fluazifop-P-butyl, fluazolate, flucarbazone, flucetosulfuron, fluchloralin, flufenacet, flufenpyr, flufenpyr-ethyl, flumetsulam, flumiclorac-pentyl, flumioxazin, fluometuron, fluoroglycofen-ethyl, flupoxam, flupyrsulfuron-methyl and its sodium salt, flurenol, flurenol-butyl, fluridone, flurochloridone, fluroxypyr, flurtamone, fluthiacet-methyl, fomesafen, foramsulfuron, fosamine-ammonium, glufosinate, glufosinate-ammonium, glufosinate-P, glyphosate and its salts such as ammonium, isopropylammonium, potassium, sodium (including sesquisodium) and trimesium (alternatively named sulfosate), halauxifen, halauxifen-methyl, halosulfuron-methyl, haloxyfop-etotyl, haloxyfop-methyl, hexazinone, hydantocidin, imazamethabenz-methyl, imazamox, imazapic, imazapyr, imazaquin, imazaquin-ammonium, imazethapyr, imazethapyr-ammonium, imazosulfuron, indanofan, indaziflam, iofensulfuron, iodosulfuron-methyl, ioxynil, ioxynil octanoate, ioxynil-sodium, ipfencarbazone, isoproturon, isouron, isoxaben, isoxaflutole, isoxachlortole, lactofen, lenacil, linuron, maleic hydrazide, MCPA and its salts (e.g., MCPA-dimethylammonium, MCPA-potassium and MCPA-sodium, esters (e.g., MCPA-2-ethylhexyl, MCPA-butotyl) and thioesters (e.g., MCPA-thioethyl), MCPB and its salts (e.g., MCPB-sodium) and esters (e.g., MCPB-ethyl), mecoprop, mecoprop-P, mefenacet, mefluidide, mesosulfuron-methyl, mesotrione, metam-sodium, metamifop, metamitron, metazachlor, metazosulfuron, methabenzthiazuron, methylarsonic acid and its calcium, monoammonium, monosodium and disodium salts, methyldymron, metobenzuron, metobromuron, metolachlor, S-metolachlor, metosulam, metoxuron, metribuzin, metsulfuron-methyl, molinate, monolinuron, naproanilide, napropamide, napropamide-M, naptalam, neburon, nicosulfuron, norflurazon, orbencarb, orthosulfamuron, oryzalin, oxadiargyl, oxadiazon, oxasulfuron, oxaziclomefone, oxyfluorfen, paraquat dichloride, pebulate, pelargonic acid, pendimethalin, penoxsulam, pentanochlor, pentoxazone, perfluidone, pethoxamid, pethoxyamid, phenmedipham, picloram, picloram-potassium, picolinafen, pinoxaden, piperophos, pretilachlor, primisulfuron-methyl, prodiamine, profoxydim, prometon, prometryn, propachlor, propanil, propaquizafop, propazine, propham, propisochlor, propoxycarbazone, propyrisulfuron, propyzamide, prosulfocarb, prosulfuron, pyraclonil, pyraflufen-ethyl, pyrasulfotole, pyrazogyl, pyrazolynate, pyrazoxyfen, pyrazosulfuron-ethyl, pyribenzoxim, pyributicarb, pyridate, pyriftalid, pyriminobac-methyl, pyrimisulfan, pyrithiobac, pyrithiobac-sodium, pyroxasulfone, pyroxsulam, quinclorac, quinmerac, quinoclamine, quizalofop-ethyl, quizalofop-P-ethyl, quizalofop-P-tefuryl, rimsulfuron, saflufenacil, sethoxydim, siduron, simazine, simetryn, sulcotrione, sulfentrazone, sulfometuron-methyl, sulfosulfuron, 2,3,6-TBA, TCA, TCA-sodium, tebutam, tebuthiuron, tefuryltrione, tembotrione, tepraloxydim, terbacil, terbumeton, terbuthylazine, terbutryn, thenylchlor, thiazopyr, thiencarbazone, thifensulfuron-methyl, thiobencarb, tiafenacil, tiocarbazil, tolpyralate, topramezone, tralkoxydim, tri-allate, triafamone, triasulfuron, triaziflam, tribenuron-methyl, triclopyr, triclopyr-butotyl, triclopyr-triethylammonium, tridiphane, trietazine, trifloxysulfuron, trifludimoxazin, trifluralin, triflusulfuron-methyl, tritosulfuron, vernolate, 3-(2-chloro-3,6-difluorophenyl)-4-hydroxy-1-methyl-1,5-naphthyridin-2(1H)-one, 5-chloro-3-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-1-(4-methoxyphenyl)-2(1H)-quinoxalinone, 2-chloro-N-(1-methyl-1H-tetrazol-5-yl)-6-(trifluoromethyl)-3-pyridinecarboxamide, 7-(3,5-dichloro-4-pyridinyl)-5-(2,2-difluoroethyl)-8-hydroxypyrido[2,3-b]pyrazin-6(5H)-one), 4-(2,6-diethyl-4-methylphenyl)-5-hydroxy-2,6-dimethyl-3 (2H)-pyridazinone), 5-[[(2,6-difluorophenyl)methoxy]methyl]-4,5-dihydro-5-methyl-3-(3-methyl-2-thienyl)isoxazole (previously methioxolin), 4-(4-fluorophenyl)-6-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-2-methyl-1,2,4-triazine-3,5(2H,4H)-dione, methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-2-pyridinecarboxylate, 2-methyl-3-(methylsulfonyl)-N-(1-methyl-1H-tetrazol-5-yl)-4-(trifluoromethyl)benzamide and 2-methyl-N-(4-methyl-1,2,55-oxadiazol-3-yl)-3-(methylsulfinyl)-4-(trifluoromethyl)benzamide. Other herbicides also include bioherbicides such as Alternaria destruens Simmons, Colletotrichum gloeosporiodes (Penz.) Penz. & Sacc., Drechsiera monoceras (MTB-951), Myrothecium verrucaria (Albertini & Schweinitz) Ditmar: Fries, Phytophthora palmivora (Butl.) Butl. and Puccinia thlaspeos Schub.

(61) Preferred for better control of undesired vegetation (e.g., lower use rate such as from greater-than-additive effects, broader spectrum of weeds controlled, or enhanced crop safety) or for preventing the development of resistant weeds are mixtures of a compound of this invention with a herbicide selected from the group consisting of atrazine, azimsulfuron, beflubutamid, S-beflubutamide, benzisothiazolinone, carfentrazone-ethyl, chlorimuron-ethyl, chlorsulfuron-methyl, clomazone, clopyralid potassium, cloransulam-methyl, 2-[(2,5-dichlorophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone, ethametsulfuron-methyl, flumetsulam, 4-(4-fluorophenyl)-6-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-2-methyl-i 1,2,4-triazine-3,5-(2H,4H)-dione, flupyrsulfuron-methyl, fluthiacet-methyl, fomesafen, imazethapyr, lenacil, mesotrione, metribuzin, metsulfuron-methyl, pethoxamid, picloram, pyroxasulfone, quinclorac, rimsulfuron, S-metolachlor, sulfentrazone, thifensulfuron-methyl, triflusulfuron-methyl and tribenuron-methyl.

(62) Compounds of this invention can also be used in combination with plant growth regulators such as aviglycine, N-(phenylmethyl)-1H-purin-6-amine, epocholeone, gibberellic acid, gibberellin A.sub.4 and A.sub.7, harpin protein, mepiquat chloride, prohexadione calcium, prohydrojasmon, sodium nitrophenolate and trinexapac-methyl, and plant growth modifying organisms such as Bacillus cereus strain BP01.

(63) General references for agricultural protectants (i.e. herbicides, herbicide safeners, insecticides, fungicides, nematocides, acaricides and biological agents) include The Pesticide Manual, 13th Edition, C. D. S. Tomlin, Ed., British Crop Protection Council, Farnham, Surrey, U. K., 2003 and The BioPesticide Manual, 2nd Edition, L. G. Copping, Ed., British Crop Protection Council, Farnham, Surrey, U. K., 2001.

(64) For embodiments where one or more of these various mixing partners are used, the mixing partners are typically used in the amounts similar to amounts customary when the mixture partners are used alone. More particularly in mixtures, active ingredients are often applied at an application rate between one-half and the full application rate specified on product labels for use of active ingredient alone. These amounts are listed in references such as The Pesticide Manual and The BioPesticide Manual. The weight ratio of these various mixing partners (in total) to the compound of Formula 1 is typically between about 1:3000 and about 3000:1. Of note are weight ratios between about 1:300 and about 300:1 (for example ratios between about 1:30 and about 30:1). One skilled in the art can easily determine through simple experimentation the biologically effective amounts of active ingredients necessary for the desired spectrum of biological activity. It will be evident that including these additional components may expand the spectrum of weeds controlled beyond the spectrum controlled by the compound of Formula 1 alone.

(65) In certain instances, combinations of a compound of this invention with other biologically active (particularly herbicidal) compounds or agents (i.e. active ingredients) can result in a greater-than-additive (i.e. synergistic or (enhanced)) effect on weeds and/or a less-than-additive effect (i.e. safening) on crops or other desirable plants. Reducing the quantity of active ingredients released in the environment while ensuring effective pest control is always desirable. Ability to use greater amounts of active ingredients to provide more effective weed control without excessive crop injury is also desirable. When synergism (enhancement) of herbicidal active ingredients occurs on weeds at application rates giving agronomically satisfactory levels of weed control, such combinations can be advantageous for reducing crop production cost and decreasing environmental load. When safening of herbicidal active ingredients occurs on crops, such combinations can be advantageous for increasing crop protection by reducing weed competition.

(66) Of note is a combination of a compound of the invention with at least one other herbicidal active ingredient. Of particular note is such a combination where the other herbicidal active ingredient has different site of action from the compound of the invention. In certain instances, a combination with at least one other herbicidal active ingredient having a similar spectrum of control but a different site of action will be particularly advantageous for resistance management. Thus, a composition of the present invention can further comprise (in a herbicidally effective amount) at least one additional herbicidal active ingredient having a similar spectrum of control but a different site of action.

(67) Compounds of this invention can also be used in combination with herbicide safeners such as allidochlor, benoxacor, cloquintocet-mexyl, cumyluron, cyometrinil, cyprosulfonamide, daimuron, dichlormid, dicyclonon, dietholate, dimepiperate, fenchlorazole-ethyl, fenclorim, flurazole, fluxofenim, furilazole, isoxadifen-ethyl, mefenpyr-diethyl, mephenate, methoxyphenone naphthalic anhydride (1,8-naphthalic anhydride), oxabetrinil, N-(aminocarbonyl)-2-methylbenzenesulfonamide, N-(aminocarbonyl)-2-fluorobenzenesulfonamide, 1-bromo-4-[(chloromethyl)sulfonyl]benzene (BCS), 4-(dichloroacetyl)-1-oxa-4-azospiro[4.5]decane (MON 4660), 2-(dichloromethyl)-2-methyl-1,3-dioxolane (MG 191), ethyl 1,6-dihydro-1-(2-methoxyphenyl)-6-oxo-2-phenyl-5-pyrimidinecarboxylate, 2-hydroxy-N,N-dimethyl-6-(trifluoromethyl)pyridine-3-carboxamide, and 3-oxo-1-cyclohexen-1-yl 1-(3,4-dimethylphenyl)-1,6-dihydro-6-oxo-2-phenyl-5-pyrimidinecarboxylate, 2,2-dichloro-1-(2,2,5-trimethyl-3-oxazolidinyl)-ethanone and 2-methoxy-N-[[4-[[(methylamino)carbonyl]amino]phenyl]sulfonyl]-benzamide to increase safety to certain crops. Antidotally effective amounts of the herbicide safeners can be applied at the same time as the compounds of this invention, or applied as seed treatments. Therefore an aspect of the present invention relates to a herbicidal mixture comprising a compound of this invention and an antidotally effective amount of a herbicide safener. Seed treatment is particularly useful for selective weed control, because it physically restricts antidoting to the crop plants. Therefore a particularly useful embodiment of the present invention is a method for selectively controlling the growth of undesired vegetation in a crop comprising contacting the locus of the crop with a herbicidally effective amount of a compound of this invention wherein seed from which the crop is grown is treated with an antidotally effective amount of safener. Antidotally effective amounts of safeners can be easily determined by one skilled in the art through simple experimentation.

(68) Compounds of the invention can also be mixed with: (1) polynucleotides including but not limited to DNA, RNA, and/or chemically modified nucleotides influencing the amount of a particular target through down regulation, interference, suppression or silencing of the genetically derived transcript that render a herbicidal effect; or (2) polynucleotides including but not limited to DNA, RNA, and/or chemically modified nucleotides influencing the amount of a particular target through down regulation, interference, suppression or silencing of the genetically derived transcript that render a safening effect.

(69) Of note is a composition comprising a compound of the invention (in a herbicidally effective amount), at least one additional active ingredient selected from the group consisting of other herbicides and herbicide safeners (in an effective amount), and at least one component selected from the group consisting of surfactants, solid diluents and liquid diluents. Table A1 lists specific combinations of a Component (a) with Component (b) illustrative of the mixtures, compositions and methods of the present invention. Compound 1 in the Component (a) column is identified in Index Table A. The second column of Table A1 lists the specific Component (b) compound (e.g., “2,4-D” in the first line). The third, fourth and fifth columns of Table A1 lists ranges of weight ratios for rates at which the Component (a) compound is typically applied to a field-grown crop relative to Component (b) (i.e. (a):(b)). Thus, for example, the first line of Table A1 specifically discloses the combination of Component (a) (i.e. Compound 1 in Index Table A) with 2,4-D is typically applied in a weight ratio between 1:192-6:1. The remaining lines of Table A1 are to be construed similarly.

(70) TABLE-US-00013 TABLE A1 Component (a) Typical More Typical Most Typical (Compound #) Component (b) Weight Ratio Weight Ratio Weight Ratio 1 2,4-D 1:192-6:1 1:64-2:1 1:24-1:3 1 Acetochlor 1:768-2:1 1:256-1:2   1:96-1:11 1 Acifluorfen  1:96-12:1 1:32-4:1 1:12-1:2 1 Aclonifen 1:857-2:1 1:285-1:3  1:107-1:12 1 Alachlor 1:768-2:1 1:256-1:2   1:96-1:11 1 Ametryn 1:384-3:1 1:128-1:1  1:48-1:6 1 Amicarbazone 1:192-6:1 1:64-2:1 1:24-1:3 1 Amidosulfuron   1:6-168:1  1:2-56:1  1:1-11:1 1 Aminocyclopyrachlor  1:48-24:1 1:16-8:1  1:6-2:1 1 Aminopyralid  1:20-56:1  1:6-19:1  1:2-4:1 1 Amitrole 1:768-2:1 1:256-1:2   1:96-1:11 1 Anilofos  1:96-12:1 1:32-4:1 1:12-1:2 1 Asulam 1:960-2:1 1:320-1:3  1:120-1:14 1 Atrazine 1:192-6:1 1:64-2:1 1:24-1:3 1 Azimsulfuron   1:6-168:1  1:2-56:1  1:1-11:1 1 Beflubutamid 1:342-4:1 1:114-2:1  1:42-1:5 1 S-Beflubutamid .sup. 1:171-4:0.5 .sup. 1:57-2:0.5 .sup. 1:21-1:2.5 1 Benfuresate 1:617-2:1 1:205-1:2  1:77-1:9 1 Bensulfuron-methyl  1:25-45:1  1:8-15:1  1:3-3:1 1 Bentazone 1:192-6:1 1:64-2:1 1:24-1:3 1 Benzobicyclon  1:85-14:1 1:28-5:1 1:10-1:2 1 Benzofenap 1:257-5:1 1:85-2:1 1:32-1:4 1 Bicyclopyrone  1:42-27:1 1:14-9:1  1:5-2:1 1 Bifenox 1:257-5:1 1:85-2:1 1:32-1:4 1 Bispyribac-sodium   1:10-112:1  1:3-38:1  1:1-7:1 1 Bromacil 1:384-3:1 1:128-1:1  1:48-1:6 1 Bromobutide 1:384-3:1 1:128-1:1  1:48-1:6 1 Bromoxynil  1:96-12:1 1:32-4:1 1:12-1:2 1 Butachlor 1:768-2:1 1:256-1:2   1:96-1:11 1 Butafenacil  1:42-27:1 1:14-9:1  1:5-2:1 1 Butylate 1:1542-1:2  1:514-1:5  1:192-1:22 1 Carfenstrole 1:192-6:1 1:64-2:1 1:24-1:3 1 Carfentrazone-ethyl 1:128-9:1 1:42-3:1 1:16-1:2 1 Chlorimuron-ethyl   1:8-135:1  1:2-45:1  1:1-9:1 1 Chlorotoluron 1:768-2:1 1:256-1:2   1:96-1:11 1 Chlorsulfuron   1:6-168:1  1:2-56:1  1:1-11:1 1 Cincosulfuron  1:17-68:1  1:5-23:1  1:2-5:1 1 Cinidon-ethyl 1:384-3:1 1:128-1:1  1:48-1:6 1 Cinmethylin  1:34-34:1  1:11-12:1  1:4-3:1 1 Clacyfos  1:34-34:1  1:11-12:1  1:4-3:1 1 Clethodim  1:48-24:1 1:16-8:1  1:6-2:1 1 Clodinafop-propargyl  1:20-56:1  1:6-19:1  1:2-4:1 1 Clomazone 1:384-3:1 1:128-1:1  1:48-1:6 1 Clomeprop 1:171-7:1 1:57-3:1 1:21-1:3 1 Clopyralid 1:192-6:1 1:64-2:1 1:24-1:3 1 Cloransulam-methyl  1:12-96:1  1:4-32:1  1:1-6:1 1 Cumyluron 1:384-3:1 1:128-1:1  1:48-1:6 1 Cyanazine 1:384-3:1 1:128-1:1  1:48-1:6 1 Cyclopyrimorate  1:17-68:1  1:5-23:1  1:2-5:1 1 Cyclosulfamuron  1:17-68:1  1:5-23:1  1:2-5:1 1 Cycloxydim  1:96-12:1 1:32-4:1 1:12-1:2 1 Cyhalofop  1:25-45:1  1:8-15:1  1:3-3:1 1 Daimuron 1:192-6:1 1:64-2:1 1:24-1:3 1 Desmedipham 1:322-4:1 1:107-2:1  1:40-1:5 1 Dicamba 1:192-6:1 1:64-2:1 1:24-1:3 1 Dichlobenil 1:1371-1:2  1:457-1:4  1:171-1:20 1 Dichlorprop 1:925-2:1 1:308-1:3  1:115-1:13 1 Diclofop-methyl 1:384-3:1 1:128-1:1  1:48-1:6 1 Diclosulam   1:10-112:1  1:3-38:1  1:1-7:1 1 Difenzoquat 1:288-4:1 1:96-2:1 1:36-1:4 1 Diflufenican 1:857-2:1 1:285-1:3  1:107-1:12 1 Diflufenzopyr  1:12-96:1  1:4-32:1  1:1-6:1 1 Dimethachlor 1:768-2:1 1:256-1:2   1:96-1:11 1 Dimethametryn 1:192-6:1 1:64-2:1 1:24-1:3 1 Dimethenamid-P 1:384-3:1 1:128-1:1  1:48-1:6 1 Dithiopyr 1:192-6:1 1:64-2:1 1:24-1:3 1 Diuron 1:384-3:1 1:128-1:1  1:48-1:6 1 EPTC 1:768-2:1 1:256-1:2   1:96-1:11 1 Esprocarb 1:1371-1:2  1:457-1:4  1:171-1:20 1 Ethalfluralin 1:384-3:1 1:128-1:1  1:48-1:6 1 Ethametsulfuron-methyl  1:17-68:1  1:5-23:1  1:2-5:1 1 Ethoxyfen   1:8-135:1  1:2-45:1  1:1-9:1 1 Ethoxysulfuron  1:20-56:1  1:6-19:1  1:2-4:1 1 Etobenzanid 1:257-5:1 1:85-2:1 1:32-1:4 1 Fenoxaprop-ethyl  1:120-10:1 1:40-4:1 1:15-1:2 1 Fenoxasulfone  1:85-14:1 1:28-5:1 1:10-1:2 1 Fenquinotrione  1:17-68:1  1:5-23:1  1:2-5:1 1 Fentrazamide  1:17-68:1  1:5-23:1  1:2-5:1 1 Flazasulfuron  1:17-68:1  1:5-23:1  1:2-5:1 1 Florasulam   1:2-420:1   1:1-140:1  2:1-27:1 1 Fluazifop-butyl 1:192-6:1 1:64-2:1 1:24-1:3 1 Flucarbazone   1:8-135:1  1:2-45:1  1:1-9:1 1 Flucetosulfuron   1:8-135:1  1:2-45:1  1:1-9:1 1 Flufenacet 1:257-5:1 1:85-2:1 1:32-1:4 1 Flumetsulam  1:24-48:1  1:8-16:1  1:3-3:1 1 Flumiclorac-pentyl   1:10-112:1  1:3-38:1  1:1-7:1 1 Flumioxazin  1:25-45:1  1:8-15:1  1:3-3:1 1 Fluometuron 1:384-3:1 1:128-1:1  1:48-1:6 1 Flupyrsulfuron-methyl   1:3-336:1   1:1-112:1  2:1-21:1 1 Fluridone 1:384-3:1 1:128-1:1  1:48-1:6 1 Fluroxypyr  1:96-12:1 1:32-4:1 1:12-1:2 1 Flurtamone 1:857-2:1 1:285-1:3  1:107-1:12 1 Fluthiacet-methyl  1:48-42:1  1:16-14:1  1:3-3:1 1 Fomesafen  1:96-12:1 1:32-4:1 1:12-1:2 1 Foramsulfuron  1:13-84:1  1:4-28:1  1:1-6:1 1 Glufosinate 1:288-4:1 1:96-2:1 1:36-1:4 1 Glyphosate 1:288-4:1 1:96-2:1 1:36-1:4 1 Halosulfuron-methyl  1:17-68:1  1:5-23:1  1:2-5:1 1 Halauxifen  1:20-56:1  1:6-19:1  1:2-4:1 1 Halauxifen methyl  1:20-56:1  1:6-19:1  1:2-4:1 1 Haloxyfop-methyl  1:34-34:1  1:11-12:1  1:4-3:1 1 Hexazinone 1:192-6:1 1:64-2:1 1:24-1:3 1 Hydantocidin 1:1100-16:1 1:385-8:1  1:144-4:1  1 Imazamox  1:13-84:1  1:4-28:1  1:1-6:1 1 Imazapic  1:20-56:1  1:6-19:1  1:2-4:1 1 Imazapyr  1:85-14:1 1:28-5:1 1:10-1:2 1 Imazaquin  1:34-34:1  1:11-12:1  1:4-3:1 1 Imazethabenz-methyl 1:171-7:1 1:57-3:1 1:21-1:3 1 Imazethapyr  1:24-48:1  1:8-16:1  1:3-3:1 1 Imazosulfuron  1:27-42:1  1:9-14:1  1:3-3:1 1 Indanofan 1:342-4:1 1:114-2:1  1:42-1:5 1 Indaziflam  1:25-45:1  1:8-15:1  1:3-3:1 1 Iodosulfuron-methyl   1:3-336:1   1:1-112:1  2:1-21:1 1 Ioxynil 1:192-6:1 1:64-2:1 1:24-1:3 1 Ipfencarbazone  1:85-14:1 1:28-5:1 1:10-1:2 1 Isoproturon 1:384-3:1 1:128-1:1  1:48-1:6 1 Isoxaben 1:288-4:1 1:96-2:1 1:36-1:4 1 Isoxaflutole  1:60-20:1 1:20-7:1  1:7-2:1 1 Lactofen  1:42-27:1 1:14-9:1  1:5-2:1 1 Lenacil 1:384-3:1 1:128-1:1  1:48-1:6 1 Linuron 1:384-3:1 1:128-1:1  1:48-1:6 1 MCPA 1:192-6:1 1:64-2:1 1:24-1:3 1 MCPB 1:288-4:1 1:96-2:1 1:36-1:4 1 Mecoprop 1:768-2:1 1:256-1:2   1:96-1:11 1 Mefenacet 1:384-3:1 1:128-1:1  1:48-1:6 1 Mefluidide 1:192-6:1 1:64-2:1 1:24-1:3 1 Mesosulfuron-methyl   1:5-224:1  1:1-75:1  1:1-14:1 1 Mesotrione  1:42-27:1 1:14-9:1  1:5-2:1 1 Metamifop  1:42-27:1 1:14-9:1  1:5-2:1 1 Metazachlor 1:384-3:1 1:128-1:1  1:48-1:6 1 Metazosulfuron  1:25-45:1  1:8-15:1  1:3-3:1 1 Methabenzthiazuron 1:768-2:1 1:256-1:2   1:96-1:11 1 Metolachlor 1:768-2:1 1:256-1:2   1:96-1:11 1 Metosulam   1:8-135:1  1:2-45:1  1:1-9:1 1 Metribuzin 1:192-6:1 1:64-2:1 1:24-1:3 1 Metsulfuron-methyl   1:2-560:1   1:1-187:1  3:1-35:1 1 Molinate 1:1028-2:1  1:342-1:3  1:128-1:15 1 Napropamide 1:384-3:1 1:128-1:1  1:48-1:6 1 Napropamide-M 1:192-6:1 1:64-2:1 1:24-1:3 1 Naptalam 1:192-6:1 1:64-2:1 1:24-1:3 1 Nicosulfuron  1:12-96:1  1:4-32:1  1:1-6:1 1 Norflurazon 1:1152-1:1  1:384-1:3  1:144-1:16 1 Orbencarb 1:1371-1:2  1:457-1:4  1:171-1:20 1 Orthosulfamuron  1:20-56:1  1:6-19:1  1:2-4:1 1 Oryzalin 1:514-3:1 1:171-1:2  1:64-1:8 1 Oxadiargyl 1:384-3:1 1:128-1:1  1:48-1:6 1 Oxadiazon 1:548-3:1 1:182-1:2  1:68-1:8 1 Oxasulfuron  1:27-42:1  1:9-14:1  1:3-3:1 1 Oxaziclomefone  1:42-27:1 1:14-9:1  1:5-2:1 1 Oxyfluorfen 1:384-3:1 1:128-1:1  1:48-1:6 1 Paraquat 1:192-6:1 1:64-2:1 1:24-1:3 1 Pendimethalin 1:384-3:1 1:128-1:1  1:48-1:6 1 Penoxsulam   1:10-112:1  1:3-38:1  1:1-7:1 1 Penthoxamid 1:384-3:1 1:128-1:1  1:48-1:6 1 Pentoxazone  1:102-12:1 1:34-4:1 1:12-1:2 1 Phenmedipham  1:102-12:1 1:34-4:1 1:12-1:2 1 Picloram  1:96-12:1 1:32-4:1 1:12-1:2 1 Picolinafen  1:34-34:1  1:11-12:1  1:4-3:1 1 Pinoxaden  1:25-45:1  1:8-15:1  1:3-3:1 1 Pretilachlor 1:192-6:1 1:64-2:1 1:24-1:3 1 Primisulfuron-methyl   1:8-135:1  1:2-45:1  1:1-9:1 1 Prodiamine 1:384-3:1 1:128-1:1  1:48-1:6 1 Profoxydim  1:42-27:1 1:14-9:1  1:5-2:1 1 Prometryn 1:384-3:1 1:128-1:1  1:48-1:6 1 Propachlor 1:1152-1:1  1:384-1:3  1:144-1:16 1 Propanil 1:384-3:1 1:128-1:1  1:48-1:6 1 Propaquizafop  1:48-24:1 1:16-8:1  1:6-2:1 1 Propoxycarbazone  1:17-68:1  1:5-23:1  1:2-5:1 1 Propyrisulfuron  1:17-68:1  1:5-23:1  1:2-5:1 1 Propyzamide 1:384-3:1 1:128-1:1  1:48-1:6 1 Prosulfocarb 1:1200-1:2  1:400-1:4  1:150-1:17 1 Prosulfuron   1:6-168:1  1:2-56:1  1:1-11:1 1 Pyraclonil  1:42-27:1 1:14-9:1  1:5-2:1 1 Pyraflufen-ethyl   1:5-224:1  1:1-75:1  1:1-14:1 1 Pyrasulfotole  1:13-84:1  1:4-28:1  1:1-6:1 1 Pyrazolynate 1:857-2:1 1:285-1:3  1:107-1:12 1 Pyrazosulfuron-ethyl   1:10-112:1  1:3-38:1  1:1-7:1 1 Pyrazoxyfen   1:5-224:1  1:1-75:1  1:1-14:1 1 Pyribenzoxim   1:10-112:1  1:3-38:1  1:1-7:1 1 Pyributicarb 1:384-3:1 1:128-1:1  1:48-1:6 1 Pyridate 1:288-4:1 1:96-2:1 1:36-1:4 1 Pyriftalid   1:10-112:1  1:3-38:1  1:1-7:1 1 Pyriminobac-methyl  1:20-56:1  1:6-19:1  1:2-4:1 1 Pyrimisulfan  1:17-68:1  1:5-23:1  1:2-5:1 1 Pyrithiobac  1:24-48:1  1:8-16:1  1:3-3:1 1 Pyroxasulfone  1:85-14:1 1:28-5:1 1:10-1:2 1 Pyroxsulam   1:5-224:1  1:1-75:1  1:1-14:1 1 Quinclorac 1:192-6:1 1:64-2:1 1:24-1:3 1 Quizalofop-ethyl  1:42-27:1 1:14-9:1  1:5-2:1 1 Rimsulfuron  1:13-84:1  1:4-28:1  1:1-6:1 1 Saflufenacil  1:25-45:1  1:8-15:1  1:3-3:1 1 Sethoxydim  1:96-12:1 1:32-4:1 1:12-1:2 1 Simazine 1:384-3:1 1:128-1:1  1:48-1:6 1 Sulcotrione  1:120-10:1 1:40-4:1 1:15-1:2 1 Sulfentrazone 1:147-8:1 1:49-3:1 1:18-1:3 1 Sulfometuron-methyl  1:34-34:1  1:11-12:1  1:4-3:1 1 Sulfosulfuron   1:8-135:1  1:2-45:1  1:1-9:1 1 Tebuthiuron 1:384-3:1 1:128-1:1  1:48-1:6 1 Tefuryltrione  1:42-27:1 1:14-9:1  1:5-2:1 1 Tembotrione  1:31-37:1  1:10-13:1  1:3-3:1 1 Tepraloxydim  1:25-45:1  1:8-15:1  1:3-3:1 1 Terbacil 1:288-4:1 1:96-2:1 1:36-1:4 1 Terbuthylazine 1:857-2:1 1:285-1:3  1:107-1:12 1 Terbutryn 1:192-6:1 1:64-2:1 1:24-1:3 1 Thenylchlor  1:85-14:1 1:28-5:1 1:10-1:2 1 Thiazopyr 1:384-3:1 1:128-1:1  1:48-1:6 1 Thiencarbazone   1:3-336:1   1:1-112:1  2:1-21:1 1 Thifensulfuron-methyl   1:5-224:1  1:1-75:1  1:1-14:1 1 Tiafenacil  1:17-68:1  1:5-23:1  1:2-5:1 1 Thiobencarb 1:768-2:1 1:256-1:2   1:96-1:11 1 Tolpyralate  1:31-37:1  1:10-13:1  1:3-3:1 1 Topramzone   1:6-168:1  1:2-56:1  1:1-11:1 1 Tralkoxydim  1:68-17:1 1:22-6:1  1:8-2:1 1 Triafamone   1:2-420:1   1:1-140:1  2:1-27:1 1 Triallate 1:768-2:1 1:256-1:2   1:96-1:11 1 Triasulfuron   1:5-224:1  1:1-75:1  1:1-14:1 1 Triaziflam 1:171-7:1 1:57-3:1 1:21-1:3 1 Tribenuron-methyl   1:3-336:1   1:1-112:1  2:1-21:1 1 Triclopyr 1:192-6:1 1:64-2:1 1:24-1:3 1 Trifloxysulfuron   1:2-420:1   1:1-140:1  2:1-27:1 1 Trifludimoxazin  1:25-45:1  1:8-15:1  1:3-3:1 1 Trifluralin 1:288-4:1 1:96-2:1 1:36-1:4 1 Triflusulfuron-methyl  1:17-68:1  1:5-23:1  1:2-5:1 1 Tritosulfuron  1:13-84:1  1:4-28:1  1:1-6:1

(71) Table A2 is constructed the same as Table A1 above except that entries below the “Component (a)” column heading are replaced with the respective Component (a) Column Entry shown below. Compound 1 in the Component (a) column is identified in Index Table A. Thus, for example, in Table A2 the entries below the “Component (a)” column heading all recite “Compound 2” (i.e. Compound 2 identified in Index Table A), and the first line below the column headings in Table A2 specifically discloses a mixture of Compound 2 with 2,4-D. Tables A3 through A7 are constructed similarly.

(72) TABLE-US-00014 Table Number Component (a) Column Entries A2 Compound 2 A3 Compound 3 A4 Compound 4 A5 Compound 5 A6 Compound 6 A7 Compound 7 A8 Compound 8

(73) Preferred for better control of undesired vegetation (e.g., lower use rate such as from synergism (enhancement), broader spectrum of weeds controlled, or enhanced crop safety) or for preventing the development of resistant weeds are mixtures of a compound of this invention with a herbicide selected from the group consisting of chlorsulfuron, ethametsulfuron, chlorimuron-ethyl, mesotrione, thifensulfuron-methyl, flupyrsulfuron-methyl, tribenuron-methyl, metsulfuron-methyl, triflusulfuron-methyl, pyroxasulfone, pinoxaden, tembotrione, pyroxsulam, metolachlor and S-metolachlor.

(74) The following Tests demonstrate the control efficacy of the compounds of this invention against specific weeds. The weed control afforded by the compounds is not limited, however, to these species. See Index Table A for compound descriptions. The abbreviation Me means methyl. The abbreviation “Cmpd. No.” stands for “Compound Number”. The abbreviation “Ex.” stands for “Example” and is followed by a number indicating in which example the compound is prepared. Mass spectra are reported with an estimated precision within ±0.5 Da as the molecular weight of the highest isotopic abundance parent ion (M+1) formed by addition of H.sup.+ (molecular weight of 1) to the molecule observed by using atmospheric pressure chemical ionization (AP+).

(75) TABLE-US-00015 INDEX TABLE A 0 Cmpd. No. R.sup.1 R.sup.2 (R.sup.3).sub.n R.sup.4 R.sup.5/R.sup.6 W L—G Mass (AP.sup.+) 1 (Ex. 1) CH.sub.3 CH.sub.3 H CH.sub.3 H/H —CH.sub.2— CH.sub.3 297 * 2 (Ex. 2) CH.sub.3 CH.sub.3 H CH.sub.3 H/H —CH.sub.2— H 283 * 3 (Ex. 3) CH.sub.3 CH.sub.3 H CH.sub.3 H/H —O— H 285 * 4 CH.sub.3 CH.sub.3 7-CH.sub.3 CH.sub.3 H/H —CH.sub.2— H 297 5 CH.sub.3 CH.sub.3 H CH.sub.3 H/H —CH.sub.2— —C(═O)CH.sub.3 325 6 CH.sub.3 CH.sub.3 H H H/H —C(CH.sub.3).sub.2— CH.sub.3 311 7 CH.sub.3 CH.sub.3 H H H/H —C(CH.sub.3).sub.2— H 297 8 CH.sub.3 Cl 7-CH.sub.3 CH.sub.3 H/H —CH.sub.2— H ** * See Synthesis Example for .sup.1H NMR data. ** M.P. = 204-229° C.

BIOLOGICAL EXAMPLES OF THE INVENTION

(76) Test A

(77) Seeds of plant species selected from barnyardgrass (Echinochloa crus-galli), kochia (Kochia scoparia), ragweed (common ragweed, Ambrosia elatior), ryegrass, It. (Italian ryegrass, Lolium multiflorum), foxtail, green (green foxtail, Setaria viridis), and pigweed (Amaranthus retroflexus) were planted into a blend of loam soil and sand and treated preemergence with a directed soil spray using test chemicals formulated in a non-phytotoxic solvent mixture which included a surfactant.

(78) At the same time, plants selected from these weed species and also wheat (Triticum aestivum), corn (Zea mays), blackgrass (Alopecurus myosuroides), and galium (catchweed bedstraw, Galium aparine) were planted in pots containing the same blend of loam soil and sand and treated with postemergence applications of test chemicals formulated in the same manner. Plants ranged in height from 2 to 10 cm and were in the one- to two-leaf stage for the postemergence treatment. Treated plants and untreated controls were maintained in a greenhouse for approximately 10 d, after which time all treated plants were compared to untreated controls and visually evaluated for injury. Plant response ratings, summarized in Table A, are based on a 0 to 100 scale where 0 is no effect and 100 is complete control. A dash (-) response means no test result.

(79) TABLE-US-00016 TABLE A 1000 g ai/ha Compound 1000 g ai/ha Compound Postemergence 1 Postemergence 1 Barnyardgrass 60 Kochia 20 Blackgrass 70 Pigweed 80 Corn 10 Ragweed 90 Foxtail, Green 60 Ryegrass, Italian 90 Galium 100 Wheat 0 500 g ai/ha Compounds 500 g ai/ha Compounds Postemergence 2 3 6 7 Postemergence 2 3 6 7 Barnyardgrass 20 10 0 30 Kochia 90 90 0 70 Blackgrass 20 10 20 10 Pigweed 90 100 0 90 Corn 10 10 0 10 Ragweed 90 90 20 70 Foxtail, Giant — — 0 10 Ryegrass, Italian 100 60 0 80 Foxtail, Green 70 20 — — Wheat 0 0 0 0 Galium 100 — 0 70 125 g ai/ha Compounds 31 g ai/ha Compounds Postemergence 2 3 4 5 6 7 8 Postemergence 4 5 8 Barnyardgrass 0 0 10 30 0 10 80 Barnyardgrass 10 20 50 Blackgrass 0 0 0 30 0 10 30 Blackgrass 0 0 20 Corn 10 0 0 20 0 0 20 Corn 0 20 0 Foxtail, Giant — — — — 0 0 80 Foxtail, Giant — — 60 Foxtail, Green 10 0 20 40 — — — Foxtail, Green 10 20 — Galium 90 — 70 90 0 50 90 Galium 40 90 90 Kochia 80 70 20 80 0 30 50 Kochia 0 70 40 Pigweed 80 80 70 100 0 80 100 Pigweed 50 70 90 Ragweed 80 60 20 80 0 0 100 Ragweed 0 30 80 Ryegrass, It. 60 10 20 80 — 30 80 Ryegrass, It. 0 70 40 Wheat 0 0 0 0 0 0 0 Wheat 0 0 0 1000 g ai/ha Compound 1000 g ai/ha Compound Preemergence 1 Preemergence 1 Barnyardgrass 80 Pigweed 60 Foxtail, Green 70 Ragweed 100 Kochia 70 Ryegrass, It. 100 500 g ai/ha Compounds 125 g ai/ha Compounds Preemergence 2 3 6 7 Preemergence 2 3 4 5 6 7 8 Barnyardgrass 0 0 30 0 Barnyardgrass 0 0 0 0 0 0 60 Foxtail, Giant — — 0 0 Foxtail, Giant — — — — 0 0 70 Foxtail, Green 0 0 — — Foxtail, Green 0 0 0 0 — — — Kochia 80 30 40 0 Kochia 0 10 0 10 0 0 10 Pigweed 80 60 0 10 Pigweed 0 10 0 100 0 0 100 Ragweed 90 50 0 0 Ragweed 40 0 0 80 0 0 30 Ryegrass, It. 50 10 0 10 Ryegrass, It. 40 0 0 70 0 0 10 500 g ai/ha Compounds 125 g ai/ha Compounds Preemergence 2 3 7 Preemergence 2 3 4 5 7 Barnyardgrass 0 0 0 Barnyardgrass 0 0 0 0 0 Foxtail, Giant — — 0 Foxtail, Giant — — — — 0 Foxtail, Green 0 0 — Foxtail, Green 0 0 0 0 — Kochia 80 30 0 Kochia 0 10 0 10 0 Pigweed 80 60 10 Pigweed 0 10 0 100 0 Ragweed 90 50 0 Ragweed 40 0 0 80 0 Ryegrass, It. 50 10 10 Ryegrass, It. 40 0 0 70 0 31 g ai/ha Compounds 31 g ai/ha Compounds Preemergence 4 5 8 Preemergence 4 5 8 Barnyardgrass 0 20 0 Pigweed 0 20 10 Foxtail, Green 0 0 0 Ragweed 0 20 0 Kochia 0 0 — Ryegrass, It. 0 40 0
Test B

(80) Plant species in the flooded paddy test selected from rice (Oryza sativa), sedge, umbrella (small-flower umbrella sedge, Cyperus difformis), ducksalad (Heteranthera limosa), and barnyardgrass (Echinochloa crus-galli) were grown to the 2-leaf stage for testing. At the time of treatment, test pots were flooded to 3 cm above the soil surface, treated by application of test compounds directly to the paddy water, and then maintained at that water depth for the duration of the test. Treated plants and controls were maintained in a greenhouse for 13 to 15 d, after which time all species were compared to controls and visually evaluated. Plant response ratings, summarized in Table B, are based on a scale of 0 to 100 where 0 is no effect and 100 is complete control. A dash (-) response means no test result.

(81) TABLE-US-00017 TABLE B 250 g ai/ha Compounds Flood 2 3 4 5 6 7 8 Barnyardgrass 0 0 0 0 0 0 60 Ducksalad 0 0 0 0 0 0 90 Rice 0 0 0 0 0 0 0 Sedge, Umbrella 0 50 0 0 0 0 95