Abstract
The impedance cardiography device comprises an impedance measuring unit, connected to the human body to be measured, a differentiator, a comparator and a microcontroller integrated with an analog-to-digital converter, characterized by that the device further comprises two peak voltage detection units with different polarities (positive and negative), the strobing outputs of them being connected to the digital (binary) inputs of the microcontroller and the analog hold outputs to the inputs of the analog-to-digital converter.
Claims
1. Impedance cardiography device, which includes an impedance measurement unit (2) connected to the human body (1) to be measured, a differentiator (3), a comparator (5) and a microcontroller (6) integrated with an analog-to-digital converter (61), wherein the impedance measurement unit (2) the output is connected to the input of the differentiator (3), the output of which is connected to the input of the analog-to-digital converter (61) integrated with the microcontroller (6) and through the comparator (5) to the first binary input of the microcontroller, wherein the device comprises a positive polarity peak value signal detection unit (4) and a negative polarity peak value detection unit (7), whose binary outputs are connected to the second and third binary inputs of the microcontroller (6), respectively.
2. The impedance cardiography device according to claim 1, wherein the unit for detecting the positive polarity peak value (4) comprises the unit (41) for holding the analog value of the positive peak value, whereby the analog output for holding the peak value of this unit is connected to the microcontroller (6) integrated analog- to the second input of the digital converter (61).
3. The impedance cardiography device according to claim 2, wherein the second input of the comparator (5) is connected through the voltage divider (9) to the analog hold output of unit (41) for detecting and holding the positive peak value.
4. The impedance cardiography device according to claim 3, wherein the transfer coefficient of said voltage divider (9) is 0.15.
5. The impedance cardiography device according to claim 2, wherein the second input of the comparator (5) is connected to the output of the digital-to-analog converter (62) integrated with the microcontroller (6).
6. The impedance cardiography device according to claim 1, wherein the units for detecting the peak value of positive and negative polarity signals are also units (41, 71) for holding the analog value of the peak value, wherein the analog outputs of the hold values of the peak value of positive and negative polarity are connected to the second and third inputs respectively of the analog-to-digital converter (61) integrated with the microcontroller (6).
7. The impedance cardiography device according to claim 2, wherein said positive peak value detection unit (4), negative peak value detection unit (7), positive peak value detection and hold unit (41) and negative peak value detection and hold unit (71) consist of an operational amplifier, a comparator, a diode, a capacitor and a resistor, with the non-inverting input of the operational amplifier connected to the input of the given unit, the output through a (semiconductor) diode to the inverting input of the same operational amplifier, which in turn is connected to ground through the parallel connection of the resistor and capacitor, and the first input of the comparator is connected with one terminal of the diode and the other input with the other terminal of the diode and the output of the comparator is the binary output of the unit.
8. The impedance cardiography device according to claim 7, wherein said positive peak value detection unit (4) and negative peak value detection unit (7) contain an analog peak value hold output connected to the inverting input of the operational amplifier.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
[0019] The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.
[0020] The invention is illustrated by the following figures.
[0021] FIG. 1 shows the ICG waveform of one cardiac cycle (see e.g. H. Yazdanian et al.) — the upper curve shows the electrical bioimpedance waveform (Z) signal, the middle — ICG signal (the first derivative of the impedance signal dZ/dt) and the lower curve the ECG (electrocardiography) waveform as for background information.
[0022] FIG. 2 shows the circuit diagram of the known solution (US4450527).
[0023] FIG. 3 shows the circuit diagram of the device according to the invention, where the positive peak value detection unit 4 and the negative peak value detection unit 7 have only a binary (strobing) outputs connected to the microcontroller.
[0024] FIG. 4 shows the circuit diagram of the device according to the invention, where the positive peak value detection and hold unit 41 has, in addition to the binary (strobing) output, also an analog peak value hold output, which is connected to the corresponding input of the analog-to-digital converter integrated with the microcontroller.
[0025] FIG. 5 shows the basic diagram of the device according to the invention, where the signal from the output of the unit 41 for detecting and holding the positive peak value is taken through the voltage divider 9 (with a transmission factor of 0.15) to the second input of the comparator.
[0026] FIG. 6 shows the basic diagram of the device according to the invention, where the second input of the comparator 5 receives a signal from the output 61 of the digital-analog converter integrated with the microcontroller 6.
[0027] FIG. 7 shows the circuit diagram of the device according to the invention, where both positive and negative peak value detection units have, in addition to the strobing output, analog peak value hold outputs 41, 71, which are connected to the inputs of the analog-to-digital converter 61 integrated with the microcontroller 6.
[0028] FIG. 8 shows the circuit diagram of a possible implementation example of the positive peak value detection unit 4 and the positive peak value detection and hold unit 41, together with the analog peak value hold output. For the negative peak value detection unit 7 and the negative peak value detection and hold unit 71, the polarity of the diode must be changed.
[0029] FIG. 9 shows the measurement configurations for ICG signal acquisition. TEPC 11 represents examples of signal measurement from chest and AEPC 12a, 12b from the wrist, and units 13 and 14 are for determining ICG fiducial points and calculating the estimated ICG parameters.
[0030] FIGS. 10 and 11 show examples of the impedance signals (from top to bottom, impedance Z, then the first derivative dZ/dt as the ICG signal, then the second derivative, which is used by a known solution, and then the ECG signal for the background), while in the case of FIG. 10, the signal comes from the chest (measurement configuration TEPC, FIG. 10) and in the case of FIG. 11 from the wrist (FIG. 11, AEPC).
EXAMPLES OF IMPLEMENTATION OF THE INVENTION
[0031] The device is connected to a human body 1, for example by electrodes on the chest 11 or on the wrist 12a, 12b (see FIG. 9). The device (FIG. 3) comprises an impedance measurement unit 2 which typically comprises, for example, a sinusoidal excitation signal generator 21 that generates an excitation signal for measurement, and a detector 22 that demodulates the response signal from the body 1. Preferably, a synchronous detector is used to demodulate the response signal. It is also reasonable to use a low-pass or band-pass filter 23 in the impedance measurement unit at the output of the signal detector, both for suppressing the ripple that occurs during demodulation and interference and artifacts.
[0032] The detected and filtered impedance (Z) signal passes through the differentiator 3, where the derivative of the impedance signal, ie the ICG signal (dZ/dt), is found. Important points B, C, X (FIG. 1) in each heart cycle are determined in the dZ/dt signal in the simplest case as follows: [0033] C is the maximum (peak value) of the dZ/dt signal in the period; [0034] B is the last zero crossing of the dZ/dt signal before point C; [0035] X is the minimum value (peak value) between two C points.
[0036] To calculate the important parameters of the heart’s work, such as CO and SV, it is necessary to know the time values and amplitudes of these three points, first of all the interval between the B and X points (LVET) and the amplitude of the C point.
[0037] In the proposed solution (according to FIG. 3), the corresponding time instances are found as follows: [0038] In order to find the C-point, there is a positive polarity peak value detection unit 4 which fixes the corresponding time moment (eg as the corresponding reading of the internal counter of the microcontroller) by using the strobing pulse, by means of which the microcontroller 6 (eg by using the interrupt function) and the ADC 61 integrated with the microcontroller 6 fixes and converts the current dZ/dt value to the corresponding numerical value of the signal; [0039] in order to find point B in the diagram, there is a comparator 5, which, when dZ/dt passes zero, generates a strobing pulse of the corresponding moment of time, by means of which the microcontroller 6 (eg using the interrupt function) fixes the corresponding moment of time (eg as a corresponding reading of the internal counter of the microcontroller); if several time values of a possible B point are fixed in the microcontroller between two C points, the last fixed value before the next C point is selected (that is, before the next C point, each possible time value of the B point overwrites the previous value); [0040] In order to find the X-point, there is a negative polarity peak value detection unit 7, which fixes the corresponding time instant (e.g. as the corresponding reading of the internal counter of the microcontroller 6) by using the strobing pulse, by means of which the microcontroller 6 (eg using the interrupt function) fixes and converts the current dZ/dt to the numerical value corresponding to the X-point of the signal.
[0041] The proposed solution according to FIG. 4 differs from the previously described solution in that the positive polarity peak value detection unit 4 (for determining the timing and value of point C) includes also the functionality of fixing the corresponding analog peak value itself and transmits the fixed (hold) value to a separate input of the analog-to-digital converter. Such a solution allows to use significantly slower ADC 61, since the positive peak value detection and hold unit 41 operates in this case as a voltage hold unit. The schematic solution of the possible peak value detection and hold unit 41 is shown in FIG. 8.
[0042] The solutions according to FIG. 5 and FIG. 6 differ in that the threshold for fixing point B (dZ/dt crossing from zero) is raised above the zero voltage (for example, to 15% of the amplitude value of point C), which is obtained in the case of FIG. 5 with a peak value with positive polarity from the hold output of the detection and hold unit 41 or, in the case of FIG. 6, generated by the digital-to-analog converter (DAC) 62 (performed, for example, by pulse-width modulation through a simple RC low-pass filter), integrated with the microcontroller 6.
[0043] The proposed solution according to FIG. 7 differs from the previously described solution in that both the positive and negative peak value detection units 4 and 7 contain also the functionality of fixing the corresponding analog peak values, and the positive peak value detection and hold unit 41 and the negative peak value detection and hold unit 71 send a fixed (hold) value to a separate input of the analog-to-digital converter. Such a solution allows the use of a significantly slower (eg integrative type) ADC 61, since the peak value detection unit works in this case as a fixed voltage holder, where the analog value is kept relatively constant for a longer time.
[0044] FIG. 8 shows an example of a possible implementation of the peak value detection unit. The circuit diagram includes an operational amplifier A1, non-inverting input of which is the input of the given unit, and negative feedback loop of it has a peak detector (D1, R1, C1). The voltage peak (maximum voltage value) is fixed on the capacitor C1. If the unit input voltage is less than the fixed peak value, the diode closes. Capacitor C1 holds a voltage that slowly decreases through resistor R1 (discharge rate depends on the time constant R1, C1).
[0045] FIG. 9 shows the measurement configurations for ICG signal acquisition. TEPC is from the chest 11 and AEPC is from the wrist 12a, 12b are examples of signals measured.
[0046] FIGS. 10 and 11 show examples of impedance signals (from top to bottom impedance Z, then the first derivative dZ/dt or ICG signal and the points B, X, C found by the proposed invention, then the second derivative used by the known solution, and then the ECG signal for background. In the case of FIG. 6, the signal originates from the chest (FIG. 5 - measurement configuration TEPC) and in FIG. 7 from the wrist (FIG. 5 - AEPC). The given results have been obtained by simulating the well-known solution proposed in this invention (US patent 4450527) as electronic circuits, using real-life captured bioimpedance signals. A particularly large difference in the improvement of the accuracy of the detection of ICG points (compared to the known solution) is in the case of the (relatively small amplitude) signal received from the wrist.
