HYDRO-ALCOHOLIC COMPOSITION FOR HAND DISINFECTION

Abstract

Disclosed is a composition for disinfecting the hands, including: a) at least one alcohol including from one to four carbon atoms, b) at least one water-in-oil emulsion containing: —a crosslinked anionic polyelectrolyte (P); —a fatty phase consisting of at least one oil (H), —water, —a water-in-oil emulsifying system (S.sub.1), and—an oil-in-water emulsifying system (S.sub.2); c) at least one compound of formula (II): R.sub.2—(C═O)—O—(CH.sub.2—CH.sub.2—O).sub.x—CH.sub.2—CH[(O—CH.sub.2—CH.sub.2).sub.y—O—(C═O)—R.sub.3]—CH.sub.2—(O—CH.sub.2—CH.sub.2).sub.2—O—(C═O)—R.sub.4 (II), wherein R.sub.2—(C═O), R.sub.3—(C═O) and R.sub.4—(C═O), identical or different, represent a saturated or unsaturated, linear or branched acyl group including from 16 to 24 carbon atoms, and wherein the sum x+y+z is greater than or equal to 30 and less than or equal to 100; and d) water.

Claims

1. A composition (C.sub.1) for hand disinfection comprising: a) at least one alcohol of formula (I):
R.sub.1—OH  (I) in which R.sub.1 represents the ethyl radical, b) at least one emulsion (ε) of water-in-oil type comprising: a crosslinked anionic polyelectrolyte (P) consisting of: at least one monomeric unit resulting from 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid in free acid or partially or completely salified form; at least one monomeric unit resulting from at least one monomer chosen from the elements of the group consisting of acrylamide, N,N-dimethylacrylamide, methacrylamide, N-isopropylacrylamide and N-(tert-butyl)acrylamide; at least one monomeric unit resulting from a polyethylenic crosslinking monomer (CA); a fatty phase consisting of at least one oil (O), water, an emulsifying system of water-in-oil type (S.sub.1), and an emulsifying system of oil-in-water type (S.sub.2); c) at least one compound of formula (II):
R.sub.2—(C═O)—O—(CH.sub.2—CH.sub.2—O).sub.x—CH.sub.2—CH[(O—CH.sub.2—CH.sub.2).sub.y—O—(C═O)—R.sub.3]—CH.sub.2—(O—CH.sub.2—CH.sub.2).sub.z—O—(C═O)—R.sub.4   (II) in which R.sub.2—(C═O), R.sub.3—(C═O) and R.sub.4—(C═O), which are identical or different, represent a saturated or unsaturated, linear or branched, acyl group comprising from 16 to 24 carbon atoms and in which the sum x+y+z is greater than or equal to 30 and less than or equal to 100; and d) water.

2. The composition (C.sub.1) as claimed in claim 1, wherein the emulsion (ε) of water-in-oil type comprises, per 100% of its weight: from 10% to 90% by weight of the crosslinked anionic polyelectrolyte (P); from 5% to 50% by weight of the fatty phase consisting of at least one oil (O); from 1% to 50% by weight of water; from 0.5% to 10% by weight of the emulsifying system of water-in-oil type (S.sub.1); and from 2% to 10% by weight of the emulsifying system of oil-in-water type (S.sub.2); the sum of the proportions by weight of compounds being equal to 100% by weight.

3. The composition (C.sub.1) as claimed in claim 1, comprising: a) from 55% to 85% by weight of alcohol comprising from 1 to 4 carbon atoms, b) from 0.5% to 3% by weight of the emulsion (ε), c) from 0.5% to 5% by weight of the compound of formula (II), d) from 14% to 37% by weight of water.

4. The composition (C.sub.1) as claimed in claim 1, further comprising an emollient and/or moisturizing agent.

5. The composition (C.sub.1) as claimed in claim 4, wherein the emollient and/or moisturizing agent is chosen from the elements of the group consisting of urea, lactic acid, hydroxyurea, triethanolamine, propane-1,2-diol, sorbitol, xylitol, erythritol, glycerol, the compound of formula (III):
HO—[CH.sub.2—CH(OH)—CH.sub.2—O].sub.p—H  (III), in which formula (III) p represents an integer greater than or equal to 2 and less than or equal to 6, the composition (C.sub.A) represented by the formula (IV):
HO—CH.sub.2—(CHOH).sub.m—CH.sub.2—O-(G).sub.x—H  (IV), in which formula (IV) G represents the residue of a reducing sugar, m represents an integer equal to 2, 3 or 4 and x, which indicates the mean degree of polymerization of said residue G, represents a decimal number of greater than 1 and less than or equal to 5.

6. The composition (C.sub.1) as claimed in claim 5, wherein the polyethylenic crosslinking monomer (CA) is chosen from the group consisting of methylenebis(acrylamide), ethylene glycol dimethacrylate, diethylene glycol diacrylate, ethylene glycol diacrylate, diallylurea, triallylamine, trimethylolpropane triacrylate, diallyloxyacetic acid or a salt thereof, or a mixture of these compounds.

7. The composition (C.sub.1) as claimed in claim 1, wherein the crosslinked anionic polyelectrolyte (P) comprises, per 100 mol %: between 20% and 90% of the monomeric unit resulting from 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid in free acid or partially or completely salified form; between 10% and 80% of the monomeric unit resulting from at least one monomer chosen from the elements of the group consisting of acrylamide and N,N-dimethylacrylamide; and a proportion of greater than 0 mol % and of less than or equal to 1 mol % of monomeric units resulting from at least one polyethylenic crosslinking monomer (CA) chosen from methylenebis(acrylamide) and triallylamine.

8. The composition (C.sub.1) as claimed in claim 1, wherein the oil (O) is chosen from the elements of the group consisting of undecane, tridecane, isododecane, isohexadecane, the C.sub.13-14 isoparaffins mixture, squalane, hydrogenated polyisobutene or hydrogenated polydecene.

9. The composition (C.sub.1) as claimed in claim 1, wherein the emulsifying system (S.sub.1) of water-in-oil type comprises at least one element of the group consisting of sorbitan laurate, sorbitan palmitate, sorbitan stearate, sorbitan oleate, sorbitan sesquioleate, sorbitan trioleate, sorbitan isolaurate, sorbitan isostearate, oleoylalkanolamide, PEG-30 dipolyhydroxystearate and trimethylolpropane-30 tripolyhydroxystearate.

10. The composition (C.sub.1) as claimed in claim 1, wherein the emulsifying system (S.sub.2) of oil-in-water type comprises at least one element of the group consisting of sorbitan oleate polyethoxylated with 20 mol of ethylene oxide, sorbitan laurate polyethoxylated with 20 mol of ethylene oxide, sorbitan palmitate polyethoxylated with 20 mol of ethylene oxide, sorbitan stearate polyethoxylated with 20 mol of ethylene oxide, tridecyl alcohol polyethoxylated with 6 mol of ethylene oxide, lauryl alcohol polyethoxylated with 7 mol of ethylene oxide, alkylpolyglycosides, compositions of fatty alcohols and of alkylpolyglycosides, polyglycerol esters, and compositions of polyglycerol esters and of polyglycerol.

11. The composition (C.sub.1) as claimed in claim 1, wherein, in the formula (II), R.sub.2—(C═O), R.sub.3—(C═O) and R.sub.4—(C═O) are identical or different and represent a saturated or unsaturated, linear or branched, acyl group chosen from the elements of the group consisting of the ricinoleoyl (or 12-hydroxy-9-cis-octadecenoyl), palmitoyl (or hexadecanoyl), stearoyl (or octadecanoyl), oleoyl (or (9Z)-octadecenoyl), linoleoyl (or (9Z, 12Z)-octadeca-9, 12-dienoyl), α-linolenoyl (or (9Z, 12Z, 15Z)-octadeca-9, 12, 15-trienoyl) and 9, 10-dihydroxyoctadecanoyl (or 9, 10-dihydroxystearoyl) radicals, or mixture thereof.

12. A method for disinfecting the hands, comprising at least one stage A of applying, to the skin of said hands, of the composition (C.sub.1) as defined in claim 1.

13. The method as claimed in claim 12, further comprising a stage B of rubbing the hands following the implementation of stage A.

14. A container comprising a manual pumping means and a packaging means, and containing a composition (C.sub.1) as defined in claim 1.

15. The composition (C.sub.1) as claimed in claim 2, comprising: a) from 55% to 85% by weight of alcohol comprising from 1 to 4 carbon atoms, b) from 0.5% to 3% by weight of the emulsion (ε), c) from 0.5% to 5% by weight of the compound of formula (II), d) from 14% to 37% by weight of water.

16. The composition (C.sub.1) as claimed in claim 2, further comprising an emollient and/or moisturizing agent.

17. The composition (C.sub.1) as claimed in claim 3, further comprising an emollient and/or moisturizing agent.

18. The composition (C.sub.1) as claimed in claim 2, wherein the crosslinked anionic polyelectrolyte (P) comprises, per 100 mol %: between 20% and 90% of the monomeric unit resulting from 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid in free acid or partially or completely salified form; between 10% and 80% of the monomeric unit resulting from at least one monomer chosen from the elements of the group consisting of acrylamide and N,N-dimethylacrylamide; and a proportion of greater than 0 mol % and of less than or equal to 1 mol % of monomeric units resulting from at least one polyethylenic crosslinking monomer (CA) chosen from methylenebis(acrylamide) and triallylamine.

19. The composition (C.sub.1) as claimed in claim 3, wherein the crosslinked anionic polyelectrolyte (P) comprises, per 100 mol %: between 20% and 90% of the monomeric unit resulting from 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid in free acid or partially or completely salified form; between 10% and 80% of the monomeric unit resulting from at least one monomer chosen from the elements of the group consisting of acrylamide and N,N-dimethylacrylamide; and a proportion of greater than 0 mol % and of less than or equal to 1 mol % of monomeric units resulting from at least one polyethylenic crosslinking monomer (CA) chosen from methylenebis(acrylamide) and triallylamine.

20. The composition (C.sub.1) as claimed in claim 4, wherein the crosslinked anionic polyelectrolyte (P) comprises, per 100 mol %: between 20% and 90% of the monomeric unit resulting from 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid in free acid or partially or completely salified form; between 10% and 80% of the monomeric unit resulting from at least one monomer chosen from the elements of the group consisting of acrylamide and N,N-dimethylacrylamide; and a proportion of greater than 0 mol % and of less than or equal to 1 mol % of monomeric units resulting from at least one polyethylenic crosslinking monomer (CA) chosen from methylenebis(acrylamide) and triallylamine.

Description

DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0175] The following examples illustrate the invention without, however, limiting it.

I—Preparation and Evaluation of Compositions According to the Invention and of Comparative Compositions

I-1. Preparation of the Compositions According to the Invention and of the Comparative Compositions

[0176] Three hydro-alcoholic compositions according to the invention, called (F.sub.1) to (F.sub.3), and ten comparative compositions, called (F′.sub.1) to (F′.sub.10), for which the proportions by weight of their constituents are respectively shown in tables 1 and 2 below, are prepared.

[0177] The preparation process common to these compositions is as follows:

TABLE-US-00001 TABLE 1 (F.sub.1) (F.sub.2) (F.sub.3) Water q.s. q.s. q.s. 100% 100% 100% 95º Ethanol  65%  65%  65% Simulgel ™ 600.sup.(1)  2%    1.6% — (IL.sub.1).sup.(2) — —    1.8% Glycerol — —  3% Simulsol ™ P23.sup.(3) — — — PEG-25 — — — hydrogenated castor oil.sup.(4) PEG-30  4%  4%  4% hydrogenated castor oil.sup.(5) Montanox ™ 80.sup.(6) — — — Montanox ™ 20.sup.(7) — — — Oramix ™ — — — CG110.sup.(8) Sepiclear ™ G7.sup.(9) — — —

Compositions According to the Invention

[0178]

TABLE-US-00002 TABLE 2 (F′.sub.1) (F′.sub.2) (F′.sub.3) (F′.sub.4) (F′.sub.5) (F′.sub.6) (F′.sub.7) (F′.sub.8) (F′.sub.9) (F′.sub.10) Water q.s. q.s. q.s. q.s. q.s. q.s. q.s. q.s. q.s. q.s. 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 95° 65% 65% 65% 65% 65% 65% 65% 65% 65% 65% Ethanol Simulgel ™ 2% 2% 2% — — — — — — — 600.sup.(1) (IL.sub.1).sup.(2) — — — 1.6% 1.6% 2.2% 1.8% 1.8% 1.8% 1.8% Glycerol — — — 3% 3% 3% 3% 3% 3% 3% Simulsol ™ — 4% — — — — — — — — P23.sup.(3) PEG-25 — — 4% — — — — — — — hydrogenated castor oil.sup.(4) PEG-30 — — — — 1% 1% — — — — hydrogenated castor oil.sup.(5) Montan — — — — — — 1% — — — OX ™ 80.sup.(6) Montan — — — — — — — 1% — — OX ™ 20.sup.(7) Oramix ™ — — — — — — — — 1% — CG110.sup.(8) Sepiclear ™ — — — — — — — — — 1% G7.sup.(9)

Comparative Compositions

[0179] (1): Simulgel™ 600 is a self-invertible inverse latex (INCI name: Acrylamide/Sodium Acryloyldimethyl Taurate Copolymer & Isohexadecane & Polysorbate 80), provided in the form of an emulsion of water-in-oil type, the polymer backbone of which comprises the acrylamide monomer and the 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid monomer in the sodium salt form and methylenebisacrylamide, in the presence of a sorbitan oleate in the water-in-oil surfactant system of the inverse emulsion.

[0180] (2) IL.sub.1): is a self-invertible inverse latex, provided in the form of an emulsion of water-in-oil type, comprising an aqueous phase itself containing a polymer, the polymeric backbone of which comprises the acrylamide monomer and the 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid monomer in the sodium salt form and methylenebisacrylamide, and the oil phase of which is a C.sub.13-14 isoparaffin, in the presence of a sorbitan oleate in the water-in-oil surfactant system of the inverse emulsion and an ethoxylated lauryl alcohol having 7 mol of ethylene oxide in the oil-in-water surfactant system of the inverse emulsion.

[0181] The emulsion KJ is prepared according to the process described above for the emulsion (ε).

[0182] (3): Simulsol™ P23 is a lauryl alcohol ethoxylated with 23 mol of ethylene oxide (MW=1198).

[0183] (4): PEG-25 hydrogenated castor oil (INCI name) is a hydrogenated and ethoxylated castor oil having 25 cools of ethylene oxide.

[0184] (5): PEG-30 hydrogenated castor oil (INCI name) is a hydrogenated and ethoxylated castor oil having 30 mol of ethylene oxide.

[0185] (6): Montanox™ 80 is an ethoxylated sorbitan monooleate having 20 mol of ethylene oxide.

[0186] (7): Montanox™ 20 is an ethoxylated sorbitan monolaurate having 20 mol of ethylene oxide (MW=1226).

[0187] (8): Oramix™ CG 110 is an aqueous composition comprising caprylyl glucoside and capryl glucoside.

[0188] (9): Sepiclear™ G7 is an aqueous composition comprising n-heptyl glucoside.

I-2. Evaluation of the Compositions According to the Invention and of the Comparative Compositions

[0189] The hydro-alcoholic compositions (F.sub.1) to (F.sub.3) according to the invention and the comparative hydro-alcoholic compositions (F′.sub.1) to (F′.sub.10) thus prepared are subsequently stored in an insulated climatic chamber regulated at a temperature of 25° C. for 7 days. On conclusion of this period of 7 days, each hydro-alcoholic composition is evaluated by the following measurements: [0190] Measurement of the dynamic viscosity (μ) at 25° C. using a viscometer of Brookfield LVT type at a speed of 6 revolutions/minute (S6), fitted with the appropriate spindle, after a period of storage at 25° C. for 7 days. [0191] Measurement of the haze of the hydro-alcoholic composition obtained at a temperature of 25° C., using an optical turbidimeter of the trade name HF Scientific™, model DRT100B, precalibrated with a formazine solution (0.9 NTU); the haze measurements are expressed in NTU units. [0192] Visual evaluation of the appearance of the hydro-alcoholic composition prepared after a period of storage at 25° C. for 7 days; the visual appearance of each hydro-alcoholic composition is noted by the experimenter and qualified as clear (CR), cloudy (CY) or cloudy-heterogeneous (CY-H), as the case may be.

[0193] The results obtained for the hydro-alcoholic compositions (F.sub.1) to (F.sub.3) according to the invention and the comparative hydro-alcoholic compositions (F′.sub.1) to (F′.sub.10) are given respectively in tables 3 and 4 below.

TABLE-US-00003 TABLE 3 Compositions according to the invention (F.sub.1) (F.sub.2) (F.sub.3) Visual (CR) (CR) (CR) appearance at 25° C. 7 days Haze (NTU) 5 9 <5 NTU NTU NTU (μ) at 25° C. 2000 2600 2400 7 days mPa .Math. s mPa .Math. s mPa .Math. s

Evaluation of the Compositions According to the Invention

[0194]

TABLE-US-00004 TABLE 4 Comparative compositions (F′.sub.1) (F′.sub.2) (F′.sub.3) (F′.sub.4) (F′.sub.5) (F′.sub.6) (F′.sub.7) (F′.sub.8) (F′.sub.9) (F′.sub.10) Visual (CY) (CY) (CY) (CY) (CY) (CY) (CY) (CY) (CY) (CY) appearance at 25° C. 7 days Haze >1000 >1000 117 50 50 825 >100 >100 100 100 (NTU) NTU NTU NTU NTU NTU NTU NTU NTU NTU NTU (μ) at 2500 5800 2500 3800 3600 30200 2100 2400 2000 2000 25° C. mPa .Math. s mPa .Math. s mPa .Math. s mPa .Math. s mPa .Math. s mPa .Math. s mPa .Math. s mPa .Math. s mPa .Math. s mPa .Math. s 7 days

Evaluation of the Comparative Compositions

I-3. Analysis of and Commentary on the Results Obtained

[0195] a) The use of solubilizing agents known to a person skilled in the art, such as, for example, Polysorbate 80, Polysorbate 20, caprylyl/capryl glucoside or n-heptyl glucoside, respectively present in the comparative compositions (F′.sub.7), (F′.sub.8), (F′.sub.9) and (F′.sub.10), does not make it possible to achieve hydro-alcoholic compositions which are transparent, namely the measurement of the haze of which is less than 25 NTU, whereas the formula (F.sub.3), also comprising 1.8% of inverse latex KJ and 3% of glycerol but also 4% by weight of a compound of formula (II) (PEG-30 hydrogenated castor oil), makes it possible to obtain a haze of less than 25 NTU.

[0196] b) Similarly, when the composition according to the invention comprises, as thickening ingredient, the emulsion (ε) (or self-invertible inverse latex) sold under the trade name Simulgel™ 600, the selection of the compound of formula (II) (PEG-30 hydrogenated castor oil), compared with the other solubilizers known to a person skilled in the art, such as, for example, PEG-30 hydrogenated castor oil or lauryl alcohol ethoxylated with 23 mol of ethylene oxide, makes it possible to obtain hydro-alcoholic compositions which are transparent, namely the measurement of the haze of which is less than 25 NTU. Thus, the hydro-alcoholic compositions (F.sub.1) and (F.sub.2) are characterized by a clear physical appearance, a viscosity of greater than or equal to 1500 mPa.Math.s and less than or equal to 10 000 mPa.Math.s, and a haze of less than 25 NTU, unlike the comparative compositions (F′.sub.2) and (F′.sub.3) and the comparative composition (F′.sub.1), which does not contain any solubilizing agent.