DEVICE FOR NEEDLE-FREE INJECTION OF A FLUID INTO AN ANIMAL
20230310133 · 2023-10-05
Inventors
- Frank ALTERMANN (Tuttlingen, DE)
- Maikel WIEDMANN (Immendingen, DE)
- Robin SAUTER (Tuttlingen, DE)
- Anika SCHMIDT (Fridingen, DE)
Cpc classification
A61D7/00
HUMAN NECESSITIES
A61M5/3007
HUMAN NECESSITIES
International classification
A61D7/00
HUMAN NECESSITIES
Abstract
A device for the needle-free injection of a fluid into an animal can include a contact device including a shaped contact surface that is shaped in conformity with a body part of the animal to which the injection is to be administered. Also included is a first injector including a front dispensing end which, during the needle-free injection, extends through a first passage opening in the shaped contact surface and protrudes in relation to the shaped contact surface in a region adjacent to the first passage opening, a first measuring device which outputs at least one first measuring signal in order to detect contact of the animal with the front dispensing end of the first injector, and a control unit which activates a needle-free injection via the first injector on the basis of the at least one first measuring signal.
Claims
1. A device for the needle-free injection of a fluid into an animal, comprising: a contact device, comprising a shaped contact surface that is shaped in conformity with a body part of the animal to which the injection is to be administered; a first injector for the needle-free injection, comprising a front dispensing end which, during the needle-free injection, extends through a first passage opening in the shaped contact surface and protrudes in relation to the shaped contact surface in a region adjacent to the first passage opening; a first measuring device that outputs at least one first measuring signal in order to detect contact of the animal with the front dispensing end of the first injector; and a control unit that activates a needle-free injection via the first injector on the basis of the at least one first measuring signal.
2. The device of claim 1, further comprising a first linear guide that carries the first injector, first linear guide mounted movably along a first displacement direction between a front end position and a triggering position and stops under spring pretensioning in the front end position, wherein the first measuring device outputs a first measuring signal when the triggering position is reached by the first injector.
3. The device of claim 2, wherein the first measuring device contactlessly detects the reaching of the triggering position.
4. The device of claim 2, wherein the contact surface is mounted displaceably between a main position and an injection position, wherein, in the main position of the contact surface, the front dispensing end of the first injector does not extend through the first passage opening in the shaped contact surface, and, in the injection position of the contact surface, the front dispensing end of the first injector extends through the first passage opening in the shaped contact surface and protrudes in relation to the shaped contact surface in a region adjacent to the first passage opening.
5. The device of claim 4, wherein the contact surface is mounted in such a manner that the contact surface is in the main position without an animal pressed against it, and that the contact surface is movable into the injection position only upon a predetermined force being exceeded by the animal pressing against it.
6. The device of claim 4, wherein the contact surface is held in the main position under spring pretensioning.
7. The device of claim 1, wherein the contact surface is mounted displaceably between a main position and an injection position, wherein, in the main position of the contact surface, the front dispensing end of the first injector does not extend through the first passage opening in the shaped contact surface, and, in the injection position of the contact surface, the front dispensing end of the first injector extends through the first passage opening in the shaped contact surface and protrudes in relation to the shaped contact surface in a region adjacent to the first passage opening.
8. The device of claim 7, wherein the contact surface is mounted in such a manner that the contact surface is in the main position without an animal pressed against it, and that the contact surface is movable into the injection position only upon a predetermined force being exceeded by the animal pressing against it.
9. The device of claim 7, wherein the contact surface is held in the main position under spring pretensioning.
10. The device of claim 1, wherein the fluid volume dispensed during the needle-free injection is adjustable.
11. The device of claim 1, wherein the first measuring device detects a force exerted on the first injector by the animal pressing against the contact surface, and thus against the front dispensing end of the first injector, and outputs first measuring signals to the control unit which activates the needle-free injection when a predetermined limit value is exceeded.
12. The device of claim 1, wherein the first measuring device detects a force exerted on the contact surface by the animal pressing against the contact surface and outputs first measuring signals to the control unit which triggers the needle-free injection when a predetermined limit value is exceeded.
13. The device of claim 1, wherein the first measuring device comprises a proximity sensor which detects the presence of the animal at the contact surface and outputs a first measuring signal to the control unit which triggers the needle-free injection on the basis of the first measuring signal of the proximity sensor.
14. The device of claim 1, wherein the first injector is a self-filling syringe.
15. The device of claim 1, further comprising: a second injector for the needle-free injection, which comprises a front dispensing end which, during the needle-free injection, extends through a second passage opening in the shaped contact surface and protrudes in relation to the shaped contact surface in a region adjacent to the second passage opening, and a second measuring device which outputs at least one second measuring signal in order to detect contact of the animal with the front dispensing end of the second injector, wherein the control unit activates a needle-free injection via the second injector on the basis of the at least one second measuring signal.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
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DETAILED DESCRIPTION
[0085] In the embodiment illustrated in
[0086] The device 1 for the needle-free injection of a fluid serves for administering injections to an animal. With the embodiment illustrated, vaccines and/or medicaments can be administered intramuscularly, for example to a chicken.
[0087] For this purpose, the contact plate 3 has a shaped contact surface 6, the shape of which is selected in such a manner that it is anatomically matched to the animal to which the vaccine or the medicament is intended to be administered. In the case of the embodiment described here, the shaped contact surface 6 is shaped in conformity with the breast region of a chicken. In particular, the contact plate 3 can be provided removably on the front side 5. Successively different contact plates 3 can therefore be fitted which are matched, for example, to the type or breed of animal to be treated, to the age of the animals and/or to the size thereof.
[0088] As can readily be seen in particular in
[0089] As can be gathered in particular from the illustration in
[0090] Furthermore, a proximity sensor 85 is also arranged on the front side 5. The proximity sensor 85 can be embodied as a capacitive sensor 85, for example.
[0091] The two cylindrical support elements 80 and 81 serve for receiving and holding the contact plate 3 which, for this purpose, has two cylindrical cavities 86, 87 on its rear side, as shown in
[0092] As can be gathered particularly readily from the illustration in
[0093] The arrangement of the two force sensors 82 and 83 makes it possible to measure the force with which the animal (here the chicken) is pressed against the contact plate 3. In particular, it is possible to detect whether the chicken is pressed obliquely or at a slant against it since, in this case, the two force sensors 82 and 83 display significantly different measuring values. The proximity sensor 85 also serves for measuring whether a chicken is lying sufficiently close to the contact plate 3. The force sensors 82 and 83 and the proximity sensor 85 can output measuring signals and transmit them to the control unit S. The control unit S can then evaluate these measuring signals and decide whether the chicken is lying correctly against the contact plate 3.
[0094] As will also be described in detail below, the two needle-free injectors 10, 12 are each mounted displaceably on a linear guide, with an injection being triggered only whenever the corresponding needle-free injector 10, 12 has been displaced by a predetermined distance. This displacement is achieved during correct use of the device 1 by the fact that the chicken is pressed with its breast region against the shaped contact surface 6 such that the front dispensing ends 9, 11 thereby come into contact through the plumage with the breast muscle (or the corresponding skin region) and are therefore pushed the predetermined distance rearward. It is therefore ensured that there is direct contact of the dispensing ends 9, 11 with the corresponding skin region at the breast muscle and then the needle-free injection can be triggered and performed successfully.
[0095] The first needle-free injector 10 together with the linear guide is described in more detail below with reference to
[0096] As can be gathered in particular from the sectional illustration in
[0097] Furthermore, a fluid port 23 is provided which is fluidically connected to the cylinder 20 via a second nonreturn valve 24, and therefore fluid can pass into the cylinder 20 via the fluid port 23. The second nonreturn valve 24 provides a block in the opposite direction (i.e. from the cylinder 20 to the fluid port 23). The second nonreturn valve 24 can therefore be referred to as an inlet valve and the first nonreturn valve 21 can be referred to as an outlet valve.
[0098] A front end 25 of a piston rod 26 is guided in the cylinder 20, and therefore the front end 25 acts as a piston. The piston rod 26 is tensioned toward the front dispensing end 9 by a spiral spring 27 and has a rearwardly protruding end 28. The piston-cylinder arrangement 16 is therefore embodied as a self-filling syringe since a movement of the piston rod 26 from its front end position, shown in
[0099] In order to carry out said described piston movement for filling purposes, a driver 30 (
[0100] To carry out such a tensioning movement, the tensioning device 17 can comprise, for example, a motor which sets a ramp track, which comprises a single winding, into rotation about an axis parallel to the longitudinal axis of the piston rod 26. A rotatable roller of the driver 30 is in contact with the ramp track, the driver 30 being mounted in the tensioning device 17 in such a manner that it is only movable parallel to the longitudinal axis of the piston rod 26 because of a guide rod 53, which is fastened to the driver 30 and is guided in a passage opening 54 on the motor housing 55. A rotational movement of the ramp track is therefore converted into a translational movement of the driver 30 parallel to the longitudinal axis of the piston rod 26. Such tensioning devices for devices for the needle-free administration are known. Reference is made here in particular to DE 10 2019 123 730 A1. Reference can be made here in particular to
[0101] By means of the rotation of the ramp track, which is caused by the motor, a movement of the piston rod 26 to the rear end position is therefore carried out. The ramp track has an upper plateau, which corresponds to the rear end position of the piston rod 26, and is held in said rotational position, as a result of which the pretensioned state of the piston-cylinder arrangement 16 according to
[0102] The upper plateau of the ramp track is connected to a lower plateau of the ramp track via a transition edge. If the ramp track is rotated further in order to carry out a needle-free injection, the roller runs over the transition edge, and therefore force is no longer present for tensioning the spring 27, and the piston rod 26 is thus abruptly accelerated toward the front dispensing end 9. Rotation of the ramp track as far as the upper plateau then leads to a next filling of the cylinder.
[0103] As can be gathered in particular from
[0104] A sensor 45 (here a Hall sensor 45) is arranged on the second rod holder 41 and is used to detect the distance from the magnet 32.
[0105] The holding rod 33 is mounted displaceably in the displacement direction in the holder 34 and pretensioned toward the contact surface 6 parallel to the displacement direction by means of a second spring 47.
[0106] The guide base 38 is fastened on a base plate 46 which, for its part, is mounted in the housing 2.
[0107] The cylinder 20 with the front dispensing end 9 and the fluid port 23 is designed as a releasable cylinder section 60 (
[0108] Since the O-ring seals 68 and 70 wear, they have to be frequently exchanged. For this purpose, the piston rod guide 63 has to be able to be removed from the cylinder section 60. Since the guide bushing 64 is fixed relatively strongly in the cylinder section 66 in order to ensure permanent operation, direct action on the guide bushing 64 with a tool for removal of the guide bushing 64 would lead to the latter being damaged.
[0109] The guide bushing 64 therefore fits with its first annular groove 66 in a laterally open collar 75 of a fixing element 76 with an external thread 77 and a hexagon socket 78. An internal thread matching the external thread 77 is provided in the corresponding receptacle of the cylinder section 60, and therefore the fixing element 76 can be screwed into the cylinder section 60 and also can be unscrewed again with a corresponding tool (e.g. hexagon key) which engages in the hexagon socket 78. Both the fixing element 76 and the cylinder section 60 are preferably formed from metal. As soon as the fixing element 76 is unscrewed, the entire piston rod guide 63 can therefore be removed so that the O-ring seals 68 and 70 can be changed.
[0110] Since the guide bushing 64 sits in the laterally open collar 75, there is a form-fitting connection in the longitudinal direction of the passage hole 65. In a direction transversely with respect to the longitudinal direction of the passage hole 65, the form-fitting connection is undone laterally only through the open region of the collar 75, and therefore the guide bushing can be pushed out laterally through the open region of the collar 75 and therefore transversely with respect to the longitudinal direction of the passage hole 65. It is therefore also possible to release the guide bushing 65 in the described manner from the fixing element 76 and then to exchange the O-ring seals 68 and 70. The guide bushing 64 with the exchanged O-ring seals 68 and 70 can then be pushed again laterally into the collar 75, and the entire piston rod guide 63 can then in turn be screwed into the cylinder section 60 in the described manner.
[0111] The wearing parts (here the O-ring seals 68, 70) can therefore be easily exchanged without the guide bushing 64 being damaged in the process.
[0112] Furthermore, it is possible to exchange the guide bushing 64 itself should this be necessary. The exchanged guide bushing 64 can then be fixed in the cylinder section 60 by means of the fixing element 76 without being damaged.
[0113] When the device 1 for the needle-free injection of a fluid is used correctly, the needle-free injector 10 is spring pretensioned on the basis of the linear guide 15 (because of the first spring 43) in its front end position in which the front dispensing end 9 extends through the first passage opening 7. If the animal (here a chicken with its breast region) is now pressed against the shaped contact surface 6, the front dispensing end 9 thereby comes into contact through the plumage with the breast muscle (or the corresponding skin region). Owing to the linear guide 15, a pressure on the front dispensing end 9 of the needle-free injector 10 leads to a movement of the needle-free injector 10 with the slide plate 31 in the direction of the second rod holder 41 counter to the force of the first spring 43. If the magnet 32 comes into contact with the second rod holder 41 (or a stop surface 48 of the second rod holder 41), the needle-free injector 10 is in its triggering position. The distance Δz covered in the process between the magnet 32 and the stop surface 48 of the second rod holder 41 (
[0114] The control unit S can actuate the needle-free injection on the basis only of the measuring signal of the sensor 45. However, it is advantageous if, for this purpose, the control unit S additionally evaluates the measuring signals of the two force sensors 82 and 83 and of the proximity sensor 85. It can readily be detected by the two force sensors 82 and 83 that the chicken is pressed in the conceived way against the contact surface 6. Should the chicken be positioned obliquely against the contact surface 6, the values of the two force sensors 82 and 83 would differ by a predetermined value which would indicate that a needle-free injection cannot be ensured. Furthermore, the measuring signal of the proximity sensor 85 can also be taken into consideration so that there is a greater degree of certainty that the chicken is lying in the predetermined manner against the contact surface 6 and is pressed against the latter.
[0115] In the case of the needle-free injection by means of the needle-free injector 10, the design causes a certain recoil in the needle-free injector 10, which could lead to the desired direct contact between the front dispensing end 9 and the breast muscle (or the corresponding skin region) being released, which may lead to a poorer needle-free injection. Therefore, the second spring 47 is arranged on the holding rod 33 in the holder 34, said spring, because of the contact between the magnet 32 and the stop surface 48, exerting an additional counterforce on the slide plate 31 and pressing the latter toward the front dispensing end 9 (and therefore toward the contact surface 6). The force of the second spring 47 is therefore connected in the triggering position to the force of the first spring 43, and therefore the recoil of the needle-free injector 10 during the injection is compensated for and thus the desired direct contact between the front dispensing end 9 and the breast muscle (or the corresponding skin region) is maintained.
[0116] The needle-free injection is followed in turn by the pretensioning of the piston rod 26 and maintaining of the pretensioned state. However, a renewed needle-free injection can be performed again only if the distance between the magnet 32 and the sensor 45 corresponds again to the value when no pressure is exerted on the front dispensing end 9 of the needle-free injector 10 (this corresponds to the removal of the animal from the contact plate 3). It can thereby be ensured that the particular animal is injected without a needle with the vaccine or the medicament just once.
[0117] The two needle-free injectors 10, 12 are provided in the described embodiment, and therefore two vaccines and/or medicaments can be injected simultaneously without a needle.
[0118] A further embodiment of the device 1 for the needle-free injection of a fluid is shown in
[0119] As can be gathered in particular from
[0120] In addition, a dose setting unit 104 with a first and a second spacer 105, 106 which can be pivoted in and are each U-shaped is provided (
[0121] If the ramp track 101 is rotated in order to carry out a needle-free injection, the roller 102 runs over the transition edge, and therefore force is no longer present for tensioning the spring 27, and the piston rod 26 is thus abruptly accelerated toward the front dispensing end 9 until the driver 30 lies against the rear end of the piston-cylinder arrangement 16. Rotation of the ramp track as far as the upper plateau then leads to a next filling of the cylinder.
[0122] In this state, by rotation of the rotary knob 107, the first or second spacer 105, 106 can then be positioned between the driver 30 and the rear end of the piston-cylinder arrangement 16. The extent of the first or second spacer 105, 106 in the longitudinal direction of the piston rod 26 then corresponds to the reduction of the stroke during the needle-free injection since, during the needle-free injection, the movement of the piston rod 26 is stopped upon contact of the driver 30 with the first or second spacer 105, 106. This leads to a lower amount of fluid (or lower volume of fluid) which is dispensed during the needle-free application. Since the first spacer 105 has a different extent here in the longitudinal direction of the piston rod 26 than the second spacer 106, two different amounts of fluid can be set by means of the spacers 105, 106, both amounts of fluid being smaller than the amount of fluid at the maximum stroke. Three different amounts of fluid can therefore be dispensed with the described device 1 for the needle-free injection of a fluid.
[0123] The first spacer 105 can comprise two, three or more sections (not shown) in the circumferential direction which each have a different extent in the longitudinal direction of the piston rod 26. The same applies to the second spacer 106. More than three different amounts of fluid can therefore be set. It is also possible for only the first or second spacer to be provided.
[0124] The dose setting unit 104 can be designed in such a manner that it can be operated manually, as is the case in the described embodiment. The user merely has to rotate the rotary button 107. Of course, the dose setting unit 104 can also be designed in such a manner that the rotation of the axis of rotation is motor-driven.
[0125] The linear guide 15 comprises the slide plate 15 and the base plate 46, the slide plate 15 having two elongated holes 110, 111 which permit the movement of the slide plate 15 in the longitudinal direction or in the displacement direction. For this purpose, the slide plate 15 is connected to the base plate 46 via two rigid cylinders 112, 113 and two elastic cylinders 114, 115.
[0126] The rigid cylinders 112, 113, which here are metal cylinders, each have a cylindrical guide pin 116, 117 which is placed into the corresponding elongated hole 110, 111 and the outside diameter of which is selected in such a manner that a relative movement between guide pin 116, 117 and elongated hole 110, 111 in the displacement direction is possible.
[0127] The elastic cylinders 114, 115 are of such elasticity that an elastic deformation is possible under customary forces against the front end 9 when an animal is pressed against the contact surface 6 of the contact plate 3, and therefore the slide plate 31 moves relative to the base plate 46 in the displacement direction because of being guided by the elongated holes 110, 111.
[0128] To detect this displacement of the slide plate 31, the holder 34 with the holding rod 33 and the magnet 32 is mounted on the bottom side of the slide plate 31. A sensor holder 118, in which the sensor 45 (here, e.g., the Hall sensor 45) is arranged, is mounted on the base plate 46. The cylinders 112-115 are screwed to the slide plate 31 and the base plate 46 by the screws in the figures (e.g.
[0129] When the device 1 for the needle-free injection of a fluid is used correctly, the needle-free injector 10 is spring-pretensioned on the basis of the linear guide 15 (because of the elastic cylinders 114, 115) in its front end position (e.g. shown in
[0130] The triggering position has to be the rear stop of the slide plate 31. A position in front of the rear stop can also be determined as the triggering position. It should merely be ensured that there is the desired contact between the skin of the animal (here breast muscle of the chicken) and the front dispensing end 9 in order to be able to perform the desired needle-free injection.
[0131] Instead of the described measurement by means of the Hall sensor 45, it is also possible for a force sensor to be provided which then measures the force by which the corresponding end 32 of the holding rod 33 is pressed against the force sensor 45. In this case, the end 32 does not have to have a magnet.
[0132] Of course, in this embodiment too, the measuring signals of the two force sensors 82, 83 and the proximity sensor 85 can also be evaluated in the described way in order to perform the needle-free injection.
[0133] In the case of the previously described embodiments, the contact plate 3 is mounted on the housing 2 in such a manner that it cannot be displaced in the displacement direction. However, it is possible to mount the contact plate 3 on the housing 2 so as to be displaceable in the displacement direction, as is shown, for example, in
[0134] On its side facing the housing 2, the contact plate 3 comprises four hollow-cylindrical receptacles (two receptacles 125, 126 are visible in the sectional view of
[0135] The four guide rods 129, 130, 131, 132 are each mounted displaceably with respect to the front side 5 of the housing 2 in such a manner that they can be pushed into the housing 2. However, the four guide rods 129, 130, 131, 132 are each pretensioned by a spring 137, 138 in the direction of the contact plate 3 in such a manner that the contact plate 3, if an animal is not pressed against the contact plate 3, is in its basic position which is shown in
[0136] If an animal is now pressed against the contact plate 3, the contact plate 3 is thereby moved in the direction of the front side 5 (the guide rods 129, 130, 131, 132 enter the housing 2) until the contact plate 3 lies against the front side 5. In this injection position of the contact plate 3, the front ends 9, 11 of the two needle-free injectors 10, 12 protrude in relation to the shaped contact surface 6 such that there is also already contact between the breast muscle and the front dispensing ends 9, 11, which contact has moved the needle-free injectors as far as the triggering position because of the described linear guide 15. The needle-free injection is thus performed, with it being ensured that the chicken is positioned correctly.
[0137] The described contact plate 3 is preferably designed in such a manner that all of the parts of the contact plate 3 move in the same way if an animal is pressed against it. In particular, the contact plate 3 can be formed as a single part.
[0138] The contact plate 3 may also be formed, for example, in two parts, with an inner part which forms at least part of the shaped contact surface 6 being displaceable in the displacement direction in relation to an outer part of the contact plate 3. This can be designed in particular as is described in DE 10 2015 122 069 A1. Reference is made in particular to