ORAL DELIVERY OF NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) AND OTHER NUTRITIONAL SUPPLEMENTS

Abstract

A method of orally administering nicotinamide adenine dinucleotide (NAD) to an individual includes placing an oral delivery vehicle containing NAD into an individual's mouth for a delivery time to allow the NAD to absorb through the blood vessels in the mouth. The oral delivery vehicle may be configured for chewing or to slowly dissolve to increase delivery time, or may be a liquid beverage that is held in the mouth for a delivery time. Additional ameliorating ingredients may be included in the oral delivery vehicle that enhance absorption through the blood vessels or into the cell or provide an additional therapeutic effect. A stimulant such as caffeine may be included in a ratio of about 1:1 to the NAD concentration.

Claims

1. An oral method of administering nicotinamide adenine dinucleotide (NAD) to an individual, comprising: a) providing an oral delivery vehicle comprising nicotinamide adenine dinucleotide; and b) placing said oral delivery vehicle into mouth of said individual for a delivery time that is effective for absorption of said nicotinamide adenine dinucleotide into blood vessels in the mouth.

2. The method of claim 1, wherein the nicotinamide adenine dinucleotide is provided in the oral delivery vehicle in a concentration of at least 10 mg.

3. The method of claim 1, wherein the nicotinamide adenine dinucleotide is provided in the oral delivery vehicle in a concentration of at least 20 mg.

4. The method of claim 1, wherein the delivery time is at least two second.

5. The method of claim 1, wherein the delivery time is at least 30 seconds.

6. The method of claim 1, wherein the delivery time is at least two minutes.

7. The method of claim 1, wherein the oral delivery vehicle further comprises caffeine.

8. The method of claim 1, wherein the oral delivery vehicle comprises a stimulant and wherein a ratio of nicotinamide adenine dinucleotide to stimulant is between 0.5:1 and 1.5:1.

9. The method of claim 8, wherein the stimulant is caffeine.

10. The method of claim 1, wherein the oral delivery vehicle further comprises cannabidiol.

11. The method of claim 1, wherein the cannabidiol in included in a concentration of at least 5 mg.

12. The method of claim 11, wherein the oral delivery vehicle comprises a stimulant and wherein a ratio of nicotinamide adenine dinucleotide to stimulant is between 0.5:1 and 1.5:1.

13. The method of claim 12, wherein the stimulant is caffeine.

14. The method of claim 1, wherein the oral delivery vehicle is a tablet.

15. The method of claim 14, wherein the tablet is a soluble tablet.

16. The method of claim 15, wherein the method comprises placing the soluble tablet under a tongue for said delivery time.

17. The method of claim 16, wherein the delivery time is at least 30 seconds.

18. The method of claim 14, wherein the tablet is chewing gum.

19. The method of claim 18, further comprising chewing on said chewing gum for said delivery time.

20. The method of claim 1, wherein the oral delivery vehicle is a beverage.

21. The method of claim 20, further comprising swallowing the beverage after the delivery time.

22. The method of claim 20, further comprising repeating placing said oral delivery vehicle into mouth of said individual for a delivery time that is effective for absorption of said nicotinamide adenine dinucleotide into blood vessels in the mouth.

23. The method of claim 22, further comprising swallowing the beverage after the delivery time.

24. The method of claim 20, wherein oral delivery vehicle comprises an ameliorating ingredient selected from the group consisting of a vitamin, an electrolyte and an amino acid.

25. The method of claim 24, wherein a portion of the ameliorating ingredient is absorbed into the individual's bloodstream through the individual's gastrointestinal tract.

26. The method of claim 1, wherein the oral delivery vehicle further comprises an ameliorating ingredient comprising a vitamin.

27. The method of claim 1, wherein the oral delivery vehicle further comprises an ameliorating ingredient comprising an electrolyte

28. The method of claim 1, wherein the oral delivery vehicle further comprises an ameliorating ingredient comprising an amino acid.

29. The method of claims 26 to 28, wherein a portion of the ameliorating ingredient is absorbed into the individual's bloodstream through the individual's gastrointestinal tract.

Description

BRIEF DESCRIPTION OF SEVERAL VIEWS OF THE DRAWINGS

[0018] The accompanying drawings are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention, and together with the description serve to explain the principles of the invention.

[0019] FIG. 1 shows a perspective view of an exemplary oral delivery vehicle that is a tablet in the form of a stick of gum.

[0020] FIG. 2 shows a perspective view of an exemplary oral delivery vehicle that is a soluble tablet and the dissolved tablet.

[0021] FIG. 3 shows a perspective view of an exemplary oral delivery vehicle that is a beverage in a beverage container.

[0022] Corresponding reference characters indicate corresponding parts throughout the several views of the figures. The figures represent an illustration of some of the embodiments of the present invention and are not to be construed as limiting the scope of the invention in any manner. Some of the figures may not show all of the features and components of the invention for ease of illustration, but it is to understood that where possible, features and components from one figure may be an included in the other figures. Further, the figures are not necessarily to scale, some features may be exaggerated to show details of particular components. Therefore, specific structural and functional details disclosed herein are not to be interpreted as limiting, but merely as a representative basis for teaching one skilled in the art to variously employ the present invention.

DETAILED DESCRIPTION OF THE ILLUSTRATED EMBODIMENTS

[0023] As used herein, the terms “comprises,” “comprising,” “includes,” “including,” “has,” “having” or any other variation thereof, are intended to cover a non-exclusive inclusion. For example, a process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Also, use of “a” or “an” are employed to describe elements and components described herein. This is done merely for convenience and to give a general sense of the scope of the invention. This description should be read to include one or at least one and the singular also includes the plural unless it is obvious that it is meant otherwise.

[0024] Certain exemplary embodiments of the present invention are described herein and are illustrated in the accompanying figures. The embodiments described are only for purposes of illustrating the present invention and should not be interpreted as limiting the scope of the invention. Other embodiments of the invention, and certain modifications, combinations and improvements of the described embodiments, will occur to those skilled in the art and all such alternate embodiments, combinations, modifications, improvements are within the scope of the present invention.

[0025] As shown in FIG. 1, an exemplary oral delivery vehicle 10 is a tablet 20 in the form of a stick of chewing gum 24. The chewing gum comprises the nicotinamide adenine dinucleotide 50 and may also include other ameliorating therapeutic ingredients such as a stimulate 60, such as caffeine, cannabidiol 70, a vitamin 80, such as a B vitamin, B6, or B12 for example, and a salt or electrolyte 90.

[0026] As shown in FIG. 2, an exemplary oral delivery vehicle 10 is a tablet 20 in the form of a soluble tablet 30 that is shown also as a dissolved tablet 32. The soluble tablet, like the stick of chewing gum is a solid but dissolves when inserted into the mouth. The soluble tablet may include gelatin, mucilage, or gum arabic. The composition may be configured to ensure the soluble table remains a solid over a delivery time, such as about one minute or more, about two minutes or more or even about five minutes or more. The soluble tablet comprises the nicotinamide adenine dinucleotide 50 and may also include other ameliorating therapeutic ingredients such as a stimulate 60, such as caffeine, cannabidiol 70, a vitamin 80, such as a B vitamin, B6, or B12 for example, and a salt or electrolyte 90.

[0027] As shown in FIG. 3, exemplary oral delivery vehicle 10 is a beverage 40 in a beverage container 42. As described herein, the beverage may be placed in the mouth and retained in the mouth for a delivery time to effectively enable the NAD to absorb through blood vessels in the mouth and into the bloodstream. After a delivery time, the beverage may be discarded or swallowed. This process may be repeated a number of times to increase the NAD concentration. The beverage comprises the nicotinamide adenine dinucleotide 50 and may also include other ameliorating therapeutic ingredients such as a stimulate 60, such as caffeine, cannabidiol 70, a vitamin 80, such as a B vitamin, B6, or B12 for example, and a salt or electrolyte 90.

[0028] It will be apparent to those skilled in the art that various modifications, combinations and variations can be made in the present invention without departing from the scope of the invention. Specific embodiments, features and elements described herein may be modified, and/or combined in any suitable manner. Thus, it is intended that the present invention cover the modifications, combinations and variations of this invention provided they come within the scope of the appended claims and their equivalents.