Gas mixture and use thereof for people to breathe as required in the event of pressure drops in aircraft or in the event of hyperventilation, and method therefor
11660410 · 2023-05-30
Assignee
Inventors
Cpc classification
B64D2231/025
PERFORMING OPERATIONS; TRANSPORTING
A61K33/00
HUMAN NECESSITIES
A61M16/0045
HUMAN NECESSITIES
B64D25/00
PERFORMING OPERATIONS; TRANSPORTING
International classification
A61M16/00
HUMAN NECESSITIES
A61K33/00
HUMAN NECESSITIES
Abstract
Gas mixture used for ventilation of passengers and crew in emergency situations. Depending on the density altitude, it has 7±5% CO2 at 15,000 ft flying altitude increasing to 17±5% CO2 at 30,000 ft flying altitude. The carbon dioxide improves the bioavailability of oxygen in the body. The gas mixture is produced by additive dosage of CO2 to either pure O2 or to a gas mixture having a fraction of N2 and a fraction of O2. The method for ensuring good ventilation in case of loss of cabin pressure, or generally in case of hyperventilation, involves making the gas mixture above available via respiration masks. The use of such a gas mixture also for ensuring good ventilation of people with limited mobility, if such ventilation is required. The prescribed amount of onboard oxygen for aircraft can thus be reduced and flight routes leading directly over high-altitude terrain may be taken.
Claims
1. A gas mixture for ensuring good ventilation of air passengers and crew in emergency situations, or generally in case of hyperventilation, comprising dependent on pressure and density altitude 7±5% CO.sub.2 at 15,000 ft flight altitude, and increasing with altitude, 17±5% CO.sub.2 at 30,000 ft flight altitude, to act as bioenhancer and thus, to improve the bioavailability of oxygen in the body, by additive dosage of the carbon dioxide to either pure O.sub.2 or to a gas mixture comprising a fraction of N.sub.2 and a fraction of O.sub.2 for ventilation.
2. The gas mixture according to claim 1, comprising dependent on pressure and density altitude 7±5% CO.sub.2 at 15,000 ft flight altitude, and increasing linearly up to 17±5% CO.sub.2 at 30,000 ft flight altitude.
3. A method for ensuring ventilation of people with limited mobility in case of need, or generally in case of hyperventilation, wherein artificial respiration masks are made available, through which the gas mixture according to claim 1 is continuously supplied upon fitting the mask to nose and mouth of the respective person.
4. The method according to claim 3, wherein the artificial respiration masks are made available to noses and mouths of the air passengers and crew in case of loss of cabin pressure in an aircraft, and upon fitting the masks, the air passengers and crew are ventilated with the gas mixture.
5. The method according to claim 3, wherein the artificial respiration masks are made available to noses and mouths of the air passengers and crew in case of loss of cabin pressure in an aircraft, and upon fitting their masks, the air passengers and crew are ventilated with the gas mixture, while a fraction of CO.sub.2 and a fraction of O.sub.2 is extracted from air exhaled by the air passengers and crew and recovered by means of additive dosage to external gases to yield a gas mixture, which is administered to the air passengers and crew.
6. A method of ensuring good ventilation, comprising supplying the gas mixture according to claim 1 to people with limited mobility, if ventilation is required, or, in case of hyperventilation.
7. The method according to claim 6, wherein the gas mixture is supplied to prolong the time period before the point of critical O.sub.2-saturation of a beginning hypoxic condition is reached in the case of conventional ventilation.
8. The method according to claim 6, wherein the gas mixture is supplied for preventing hypercapnia as occurs during hyperventilation.
9. The method according to claim 6, wherein the gas mixture is supplied for stabilizing the pH-value of the blood in relation to added O.sub.2.
10. A method of ensuring good ventilation, comprising supplying the gas mixture according to claim 1 to the air passengers and crew in emergency situations, including depressurization of an aircraft cabin.
11. A commercial aircraft system for an aircraft for increasing bridging time in case of an emergency due to pressure loss during which the aircraft descends to a lower altitude at which commercial air passengers can breathe without artificial respiration, comprising: a supply of CO.sub.2 gas; and a commercial air passenger ventilation system connected to the supply of CO.sub.2 gas and configured to deliver to the commercial air passengers in an aircraft cabin of the aircraft in case of the emergency a gas mixture comprising 7±5% CO.sub.2 at 15,000 ft flight altitude, increasing with altitude to 17±5% CO.sub.2 at 30,000 ft flight altitude; wherein the CO.sub.2 gas when delivered to the commercial air passengers acts as a bioenhancer to improve bioavailability of oxygen in the body by additive dosage of the CO.sub.2 gas to either pure O.sub.2 or to a gas comprising a fraction of N.sub.2 and a fraction of O.sub.2 for ventilation.
12. The commercial aircraft system according to claim 11, wherein the commercial air passenger ventilation system is configured to deliver to the commercial air passengers in the aircraft cabin in the case of the emergency the gas mixture comprising 7±5% CO.sub.2 at 15,000ft flight altitude and increasing linearly up to 17±5% CO.sub.2 at 30,000 ft flight altitude.
13. The commercial aircraft system according to claim 11, wherein the commercial air passenger ventilation system comprises artificial respiration masks for delivering the gas mixture to the commercial air passengers in the aircraft cabin in the case of the emergency.
14. A method for ensuring ventilation of commercial air passengers, comprising: providing the commercial aircraft system of claim 11, providing each commercial air passenger with an artificial respiration mask configured to be fit to the nose and mouth of each commercial air passenger, and continuously delivering to each commercial air passenger the gas mixture through the artificial respiration masks.
15. The method according to claim 14, wherein the artificial respiration masks are made available to each commercial air passenger in the event of a loss of cabin pressure in the aircraft, and upon fitting the masks, the commercial air passengers are ventilated with the gas mixture.
16. The method according to claim 14, wherein the artificial respiration masks are made available to each commercial air passenger in case of loss of cabin pressure in the aircraft, and upon fitting the masks, each commercial air passenger is ventilated with the gas mixture, while a fraction of CO.sub.2 and a fraction of O.sub.2 is extracted from the air exhaled by the commercial air passengers and recovered by additive dosage to external gases to yield a gas mixture, which is administered to the commercial air passengers.
17. The method according to claim 14, wherein the gas mixture is supplied to prolong a time period before a point of critical O.sub.2-saturation indicating a hypoxic condition is reached with conventional ventilation.
18. The method according to claim 14, wherein the gas mixture is supplied for preventing hypercapnia as occurs during hyperventilation.
19. The method according to claim 14, wherein the gas mixture is supplied for stabilizing the pH-value of the blood in relation to added O.sub.2.
20. A method for shortening commercial flight paths for commercial passenger aircraft by increasing a number of emergency escape routes for the commercial passenger aircraft in case of rapid cabin pressure loss, comprising equipping the commercial aircraft with the system of claim 11, the system operable to provide each commercial air passenger with an artificial respiration mask that continuously delivers to each commercial air passenger the gas mixture through the artificial respiration masks.
21. The commercial aircraft system according to claim 11, wherein the amount of CO.sub.2 gas delivered by the commercial air passenger ventilation system includes CO.sub.2 gas recovered from the commercial air passengers in the aircraft cabin of the aircraft.
22. The method according to claim 14, wherein the amount of CO.sub.2 gas delivered to each commercial air passenger through the respective artificial respiration mask includes CO.sub.2 gas recovered from the respective commercial air passenger.
23. A commercial aircraft, comprising: a cabin for seating commercial air passengers, a supply of gas mixture enriched with CO.sub.2 relative to air at sea level, and a passenger ventilation system configured to deliver the gas mixture enriched with CO.sub.2 to the commercial air passengers in the cabin that varies from 7±5% CO2 at 15,000ft flight altitude to 17±5% CO2 at 30,000ft flight altitude.
24. The commercial aircraft according to claim 23, wherein the amount of enriched CO.sub.2 varies depending on a flying altitude of the commercial aircraft.
25. The commercial aircraft according to claim 23, further comprising respiration masks for delivering the gas mixture to the commercial air passengers.
26. The commercial aircraft according to claim 23, wherein the supply of gas mixture enriched with CO.sub.2 relative to air at sea level is obtained in part from carbon dioxide and oxygen supplied by the commercial air passengers.
27. The commercial aircraft according to claim 23, wherein the amount of enriched CO.sub.2 varies from 7±5% CO2 at 15,000ft flying altitude increasing to 17±5% CO2 at 30,000ft flying altitude.
Description
BRIEF DESCRIPTION OF DRAWINGS
(1) In the drawings:
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DESCRIPTION OF EMBODIMENTS
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(12) An emergency escape route system complying with the regulatory safety provisions has been developed for all flight routes over high altitude mountains. An example of such a system is shown in
(13) Some airliners and business jets are equipped with high-capacity gaseous emergency oxygen systems, also known as burning systems (due to the heat generation resulting from the chemical reaction, by means of which oxygen can be produced aboard). Accordingly, a small number of airliners that cover long distances over high mountain regions are equipped with such high-capacity oxygen devices. However, the oxygen tanks and the essential equipment involved result in additional weight, which is detrimental to flight performance—especially in the event of an engine failure, when only a reduced number of engines provide thrust. In such a scenario, the effective resulting OEI (one-engine inoperable) service ceiling depends on a series of factors, including the number of engines remaining operative, and particularly on the weight of the aircraft. The flight team needs to strictly adapt the procedure of an emergency drift-down to these conditions.
(14) In an event of cabin depressurization the specific provisions of ICAO apply. The specific descent profiles prescribed by different aircraft manufacturers or airlines, respectively are derived therefrom. In general, the ICAO prescribes two different drift-down profiles, a standard descent profile and an optional descent profile for exceptional routes. Two such profiles with specific values determined by Boeing are shown in
(15) In fact, the conventional cabin pressure loss scenario assumes fully functioning engines, which in principle allows airspeeds higher than in the event of engine failure. One might therefore expect that obstacles such as high-altitude terrain could more likely be overflown within the prescribed time interval, thus imposing less stringent requirements on route planning. In reality, however, it must be assumed that cabin depressurization is caused initially by a structural failure, so that the airspeed must be adjusted immediately, that is to say reduced. Therefore, it is not possible to overfly the large expanses of high-altitude terrain without restrictions and still comply with descent profiles described above.
(16) Oxygen undersupply to body tissue in healthy people is usually attributable to an O.sub.2-poor environment. Probably, the greatest risk of acute oxygen deficiency for an average healthy human is cabin depressurization in an aircraft. If cabin pressure drops unexpectedly at high flight altitudes, the low partial pressure of oxygen leads to an undersupply of oxygen to body tissue (hypoxia). Hypoxia can result in severe organ damage, possibly even leading to death. One insidious characteristic of hypoxia is that it is not always detected or is detected too late by the person concerned, so he/she is already limited in his/her ability to take corrective action. Symptoms of hypoxia include the spectrum from wrong self-assessment, euphoria, fatigue, disorientation, to unconsciousness. In aviation, hypoxia is considered an extremely serious physical condition, which can have fatal consequences, especially for the crew of an aircraft.
(17) While supplying pure oxygen to humans, the partial pressure of oxygen is increased five-fold. According to Henry's Law, the partial pressure of a gas over a liquid is proportional to the concentration of the gas (physically) dissolved in this liquid. Thus, when supplying the body with pure oxygen, the proportion of the dissolved oxygen in the blood increases five-fold. On the other hand, the gas law does not apply to the oxygen which is chemically bonded to the haemoglobin of red blood cells. Under normal breathing conditions, the oxygen saturation of blood already amounts to 95-100%. Thus, during ventilation mainly the proportion of the physically dissolved oxygen is enriched. The latter is then pressure-dependent. If a human inhales pure oxygen at an atmospheric pressure of 2.5 bar, 20 times the amount of oxygen is dissolved in blood compared to standard conditions. This “systematic hyperbaric oxygenation therapy” is used when low blood oxygen in the body tissue prevents the healing process of patients, or when oxygen must be supplied as a life-saving measure in emergency situations. However, hyperbaric oxygenation has so far not found wide clinical application, mainly because of the side effects of high oxygen content and excess pressure. The oxygen therapy in intensive-care medicine is one of the main causes of oxygen toxicity damage.
(18) The pressure of breathing air is a highly regulating parameter. It can also exert a moderating influence when enriching blood with oxygen. In the case of continuous, controlled ventilation, as in space travel for example, ventilation using pure oxygen must be operated at low pressures, i.e. ambient pressure is not allowed to exceed 0.3 bar. Thus, the barometric pressure and consequently the oxygen partial pressure of the supplied respiratory air is reduced (cf. oxygen partial pressure of 0.21 bar under normal pressure). With continuous ventilation with pure oxygen, the risk of oxygen intoxication is present as early as pressures above said value of 0.3 bar.
(19) Ventilation with pure oxygen can be made possible for various scenarios if the ambient pressure is varied accordingly, but its conflicting characteristics mean that the oxygen cannot be supplied alone in the doses required to counteract oxygen insufficiency without side effects. Surprisingly, it was discovered in experiments and test runs that inhalation of a gas mixture comprising 7±5% CO.sub.2 at 15,000 ft altitude, and increasing to 17±5% CO.sub.2 at 30,000 ft altitude, vastly improves both the physical and mental functionality of the body in a condition of acute oxygen undersupply, compared to that resulting from pure oxygen supply. The improvement is unprecedented.
(20) If an undersupply of oxygen occurs in the body, the body reacts by accelerating the breathing rate. The increase in the breathing rate causes more oxygen to be inhaled per unit time, but at the same time more carbon dioxide is exhaled. In the body, carbon dioxide is chemically bound as carbonic acid (H.sub.2CO.sub.3). From the formula below
CO.sub.2+2H.sub.2OHCO.sub.3.sup.−+H.sub.3O.sup.+
H.sub.2CO.sub.3+H.sub.2O
the chemical balance indicates that reducing CO.sub.2 in the body results in the number of H.sub.3O.sup.+-ions in the blood to be reduced equally. This causes a shift in the acid-base equilibrium, because the blood becomes increasingly alkaline. In extreme cases, this results in a respiratory alkalosis with symptoms of muscle cramps, impairment of consciousness, even loss of consciousness. Moreover, the increase in the pH-value of blood effects a decrease in the concentration of freely dissolved ionized calcium (hypocalcaemia), leading to hyperexcitability of the musculature and nervous system, exhibiting spasmodic symptoms. Conversely, an increased concentration of carbon dioxide in the blood shifts the pH-value of the blood into the acidic range. Carbon dioxide-sensitive receptors are located on the vessels of many organs. Depending on the specific organ, the blood vessels either contract or expand under the influence of carbon dioxide. The vessels of the brain expand upon an increase of carbon dioxide concentration. The blood-flow rate increases and with it, the oxygen amount reaching the cells per unit time. In this way, the body attempts to compensate for the oxygen undersupply, and in particular, to supply the brain with sufficient oxygen for as long as possible. The opposite effect is observed, if the body is supplied with high oxygen dosage, while reducing the carbon dioxide supply. A hypocapnia, i.e. a low carbon dioxide partial pressure in the arterial blood, leads to contraction of blood vessels in the brain and consequently reduces of the blood and oxygen supply. When cabin pressure is lost in an aircraft, an undersupply of oxygen to the body occurs. The body begins to hyperventilate. Even if a passenger reaches quickly for the artificial respiration mask, the tendency to hyperventilate is further increased by the stress-induced circumstances. Hyperventilation accelerates the rate at which carbon dioxide is exhaled. This reduces the level of carbon dioxide in the body. Since the ventilated air passenger's mobility is limited due to the circumstances, less carbon dioxide is produced by the muscular cells and the effect of the carbon dioxide deficiency is accelerated accordingly. For air passengers, who are restricted to their seats for most of the time, and most particularly in emergency situations, this limitation of mobility may have severe consequences, because the body then produces less carbon dioxide. Not least because of this fact, a rapid descent to a safe flight altitude is essential for survival.
(21) If a dosed, pressure-dependent amount of carbon dioxide is added to the breathing gas, the effects as mentioned in the section above can be diminished. As the active supply of carbon dioxide to the body relaxes blood vessels in the brain, the oxygen supply to the body tissue takes place in a more efficient manner, while at the same time the amount of oxygen is reduced. Oxygen is then reabsorbed more quickly and to a greater extent, and so provided to the tissue and cells, respectively. The gas mixture according to the invention ensures respiration in emergency situations and in doing so, increases the bioavailability of oxygen, in particular oral bioavailability, because carbon dioxide in precisely measured doses acts as a bioenhancer. Finally, because of the gas mixture according to the invention the body is kept at a physiological level of carbon dioxide with just a partial dose of oxygen and over a substantially longer period. This provides significant advantages, particularly in cases of depressurization of aircraft cabins.
(22) Surprisingly, aeromedical experiments have demonstrated that by inhalation of air enriched with carbon dioxide aviation standard values can be attained: for a bridging time of maximally one minute, 84% oxygen saturation of the blood is prescribed, and for bridging time lasting more than one minute, 90% oxygen saturation of the blood is required. For the experiments, test persons were administered the amount of carbon dioxide required to maintain the carbon dioxide level in the blood at a partial pressure of 40 mmHg at different density altitudes. The respiratory air was prepared such that it comprised the following amounts of carbon dioxide at distinct density altitudes: 8% CO.sub.2 at 15,000 ft, 11% CO.sub.2 at 20,000 ft, and 16.5% CO.sub.2 at 30,000 ft. The addition of carbon dioxide to the gas mixture was at the expense of nitrogen. Consequently, the gas mixture for ventilation was composed as follows:
(23) At 15,000 ft density altitude: 21% O.sub.2, 8% CO.sub.2, 71% N.sub.2
(24) At 30,000 ft density altitude: 21% O.sub.2, 16.5% CO.sub.2, 62.5% N.sub.2
(25) Each test person had to undergo two simulated emergency descent profiles from 37,000 ft to 10,000 ft altitude, the descent corresponding to the profiles specified by the ICAO. During the one descent, the test persons inhaled pure oxygen as is usually the case in a cabin pressure loss scenario, and during the other descent, the same test persons inhaled a gas mixture with carbon dioxide added as described above. The experiment was structured in a randomized, double-blind protocol. Neither observers nor test persons knew which gas mixture would be supplied in which descent. The results indicate the following key benefits: 1. The amount of cabin oxygen aboard an aircraft can be reduced. 2. Based on the adapted drift-down procedures, more direct flight routes can be flown, thus saving essential costs and time. 3. Since—as a consequence of the above—less onboard fuel is needed, the cargo capacity of the aircraft increases. 4. Owing to the reduced fuel consumption the environment is protected.
(26) A particularly elegant aspect of the overall approach regarding the method of additive dosing of carbon dioxide according to the invention is that a passenger himself produces at least part of the required carbon dioxide and oxygen for the purpose of ventilation, respectively. Breathing air under normal ambient pressure consists of approx. 78% nitrogen (N.sub.2), 21% oxygen (O.sub.2) and approx. 1% residual gases. By contrast, exhaled air consists of approx. 78% nitrogen (N.sub.2), 16% oxygen (O.sub.2), 4% carbon dioxide (CO.sub.2) and approx. 2% residual gases. The exhaled amount of carbon dioxide and oxygen can be recovered. Dosing of the gas mixture according to the invention can thus be accomplished using carbon dioxide and oxygen supplied by the ventilated person him/herself, which is then eventually inhaled again by him/her, while the remaining gas fraction is added synthetically. The higher the density altitude, the more carbon dioxide needs to be dosed additively at the expense of nitrogen.
LIST OF REFERENCE NUMERALS
(27) 1 Actual flight route 2 Direct route which may not be flown 3 Minimum required ground clearance 4 Terrain elevation profile 5 Drift-down 6 Gross flight path 7 Net flight path 8 Positive climb gradient begins 9 Route which may not be flown 10 Critical point 1 11 Ideal turn point 1 12 Critical point 2 13 Ideal turn point 2 14 Critical point 3 15 High mountain region 16 Lowland 17 South American west coast 18 Engine failure 19 Optional 22-Minute System 20 Standard 12-Minute System 21 Minimum required vertical clearance 22 Terrain elevation profile 23 Course of the descent profile curve below the terrain elevation profile 22 24 Critical point
Checklist Points (