Hypochlorous acid disinfectant and its production method

Abstract

A novel hypochlorous acid disinfectant and its production method. The disinfectant is prepared by weight in a total of 100% as chlorine powder (dichloroisocyanuric acid, sodium salt or trichloroisocyanuric acid) of 20 to 45%, adding sodium dihydrogen phosphate or citric acid, or ingredients or raw materials with acidic pH of 15 to 40% as a main ingredient, calcium chloride of 15 to 20%, excipients of 3 to 8%. The method includes: stirring the chlorine powder with the calcium chloride; adding the sodium dihydrogen phosphate, the citric acid, the ingredients, or raw materials with acidic pH in order; and adding the excipient while stirring for 20 to 30 minutes until completely uniform to prepare the hypochlorous acid disinfectant. This disinfectant is quantitatively accurate, does not need to calculate the ratio, and is convenient to use and safe to transport.

Claims

1. A hypochlorous acid disinfectant powder consisting of: 20 to 45 weight percent of dichloroisocyanuric acid, sodium salt or trichloroisocyanuric acid; 15 to 40 weight percent of an organic acid or an inorganic acid; 15 to 20 weight percent of calcium chloride; and 5 to 12 weight percent of sodium carboxymethyl cellulose.

2. A production method for preparing the hypochlorous acid disinfectant powder of claim 1, comprising the steps of mixing dichloroisocyanuric acid, sodium salt or trichloroisocyanuric acid with the inorganic acid or the organic acid, calcium chloride, 5 to 10 weight percent of sodium bicarbonate, and sodium carboxymethyl cellulose of 3 to 8%; and after mixing making hypochlorous acid tablets by tableting.

3. A production method for preparing the hypochlorous acid disinfectant powder of claim 1, comprising the steps of: providing dichloroisocyanuric acid, sodium salt or trichloroisocyanuric acid; adding the inorganic acid or the organic acid, calcium chloride, sodium carboxymethyl cellulose, and 5 to 10 weight percent of sodium bicarbonate; and putting the raw materials into a bag A and a bag B, and when in use, then separately adding the bag A and the bag B into water in order and mixing to generate hypochlorous acid solution, wherein the bag A comprises dichloroisocyanuric acid, sodium salt or the trichloroisocyanuric and calcium chloride, and the bag B comprises the organic acid or the inorganic acid.

4. A production method for preparing the hypochlorous acid disinfectant powder of claim 1, comprising: preparing a hypochlorous acid disinfectant power by mixing dichloroisocyanuric acid, sodium salt or the trichloroisocyanuric with calcium chloride, the organic acid or the inorganic acid, and adding 5 to 10 weight percent of sodium bicarbonate and sodium carboxymethyl cellulose; and after the step of mixing, preparing the hypochlorous acid disinfectant powder, increasing or decreasing an amount of the hypochlorous acid disinfectant power according to a desired concentration of hypochlorous acid when preparing a solution of the hypochlorous acid disinfectant power in water.

5. A production method for preparing the hypochlorous acid disinfectant powder of claim 1, comprising: step A1: raw materials are first placed and dried at a temperature of 40 to 50° C. for 4 to 5 hours, after that drying, the moisture is measured, and the moisture content of each raw materials shall be 2% for conformity, the raw materials comprising: dichloroisocyanuric acid sodium salt or trichloroisocyanuric acid, the organic acid or the inorganic acid, calcium chloride, and sodium carboxymethyl cellulose; and step A2: the raw materials are ground so that the raw materials are fully mixed; step A3: the raw materials after drying are sieved with a 50-80 mesh screen, and during the sieving the temperature of the production room shall be controlled at 18° C.-25° C. and the relative humidity at 20%-25% to prevent impurities and particles in the raw materials; step A4: according to composition requirements, weigh dichloroisocyanuric acid, sodium salt or trichloroisocyanuric acid, calcium chloride, the organic acid or the inorganic acid, and sodium carboxymethyl cellulose in order, and then firstly put dichloroisocyanuric acid, sodium salt or trichloroisocyanuric acid and calcium chloride in a mixer for stirring, then add the organic acid or the inorganic acid and sodium carboxymethyl cellulose, and after mixing well for 20 to 30 minutes, take samples from different mixing locations, and determine the pH value of the finished product of the hypochlorous acid disinfectant as 4 to 6.5 and the concentration of the hypochlorous acid must reach 200 ppm or higher; step A5: the finished product of the hypochlorous acid disinfectant is tested, and if it fails, it will be scrapped; step A6: confirm that the hypochlorous acid disinfectant is acceptable; and step A7: fill the hypochlorous acid disinfectant into an aluminum foil bag or a moisture-proof bag.

6. The production method according to claim 5, wherein in the step A1, the moisture of all the raw materials should not exceed 2%, the temperature is 15-25° C., and the relative humidity is 20-25%, and the raw materials are added in order, and dichloroisocyanuric acid, sodium salt or trichloroisocyanuric acid and the organic acid or the inorganic acid are not directly stirred, and dichloroisocyanuric acid, sodium salt or trichloroisocyanuric acid and calcium chloride are mixed first and then mixed with other components and stirred.

7. The production method according to claim 5, wherein the production method of the disinfectant comprises: step B1: grind the hypochlorous acid disinfectant powder in the step A6 into a fine powder and mix with sodium carboxymethyl cellulose; step B2: test a semi-finished product of the hypochlorous acid; step B3: put the semi-finished product of the hypochlorous acid into a tableting press; step B4: make hypochlorous acid tablets with the tableting press; step B5: conduct a hypochlorous acid tablet hardness test; step B6: conduct a hypochlorous acid tablet conformity test; step B7: fill the aluminum foil bag with the hypochlorous acid tablets and seal it by a machine; step B8: load the hypochlorous acid tablets into finished boxes; step B9: load the boxes of the hypochlorous acid tablet into cartons; step B10: sum up a daily production quantity of the hypochlorous acid tablets and prepare a production report; step B11: ship the hypochlorite tablets, wherein in the step B1, grind the hypochlorous acid disinfectant powder into the fine powder, and mix with sodium carboxymethyl cellulose to be well and uniform, and determine the moisture content, wherein the moisture content is 1% or less, the semi-finished product of the hypochlorous acid after being test in the step B2 is put into the tableting press in the step B3, to automatically conduct the tableting in the step B4, wherein during tableting, the moisture of the raw materials is ≤1%, the temperature is 15 to 25° C., and the humidity is 20 to 25%, in the step B5, the tablet is checked and weighed every 10 minutes to prevent the weight of the tablet from being incorrect, after confirming that the tablet is acceptable in the step B6, the hypochlorous acid tablets are packed in the aluminum foil bag and sealed in the step B7, the hypochlorous acid tablets are loaded into the finished box and marked with a lot number and an expiration date in the step B8; in the step B9, the finished boxes of the hypochlorous acid tablets are loaded into the cartons and marked with the lot number, and in the step B10, the lot number of the finished product of the hypochlorous acid tablets are recorded daily.

8. The production method according to claim 7, wherein in the step B5, a hardness check is carried out, 10 pieces are sampled, in the step B6, samples for each lot of the finished product are kept for future inspection, and each batch of the finished product are accompanied by a test report.

9. The production method according to claim 7, wherein in the steps B7, B8 and B9, the finished products are packed into the aluminum foil bag and marked with the lot number with an automatic inkjet machine, and sealed with a film, every 5 bags are packed in a box, and put with a product manual, then marked with the lot number, production data and an expiration date, and sealed with a box film, every 24 boxes are packed into one box and marked with the lot number, and in the step B10, before the finished products are packed into a warehouse, the lot number, product specifications and other information of the finished products are checked one by one, and verified that they are correct before entering the warehouse.

10. The hypochlorous acid disinfectant powder of claim 1, wherein the inorganic acid is sodium dihydrogen phosphate or the organic acid is citric acid.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) FIG. 1 shows the relationship between the percentage of hypochlorous acid and pH;

(2) FIG. 2 shows the time required for hypochlorous acid and hypochlorous group ion to kill coliform. The bactericidal power of chlorine compounds (see U.S. EPA, partially added);

(3) FIG. 3 shows a flow chart of a production method for the novel hypochlorous acid agent according to the present invention; and,

(4) FIG. 4 shows a flow chart of a production method for the novel hypochlorous acid disinfectant according to the present invention.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

(5) The following describes the specific embodiments of the present invention in detail in combination with specific situations:

(6) This application presents a novel disinfection product through the scientific configuration of its components, maximizing the superiority of its properties and other components.

Embodiment 1, an Example is Described as Below

(7) The novel hypochlorous acid disinfectant of the invention is calculated by weight percentage, in a total of 100%, a novel chlorine powder (dichloroisocyanuric acid, sodium salt or trichloroisocyanuric acid) of 50%, adding sodium dihydrogen phosphate, or citric acid or ingredients or raw materials with acidic of 35% as a main ingredient, calcium chloride of 15%, and excipient of 10%. The production method thereof is to mix the novel chlorine powder with the calcium chloride, then add the sodium dihydrogen phosphate or the citric acid, or ingredients or raw materials with acidic pH in turn, and then add the excipient, and after stirring well for about 20 to 30 minutes, novel hypochlorous acid disinfectant in this application case will be made.

Embodiment 2, an Example is Described as Below

(8) The novel a novel hypochlorous acid disinfectant of the present invention, with the same ingredients as the above, is prepared by weight in a total of 100%, a novel chlorine powder (dichloroisocyanuric acid, sodium salt or trichloroisocyanuric acid) of 33%, adding sodium dihydrogen phosphate or citric acid, or ingredients or raw materials with acidic pH of 26% as a main ingredient, and calcium chloride of 12%, and adding sodium bicarbonate of 17% and excipients of 12% while stirring. After well stirring for about 20 to 30 minutes, the hypochlorous acid disinfectant of the present invention is made after being tableted by a tableting press. The tablets of the present invention may be increased or decreased in raw material and percentage according to the concentration of hypochlorous acid on demand, and the properties of slow or instant dissolution.

(9) For detailed production methods, please refer to the flowcharts in FIGS. 3 and 4. The standards and requirements for the production process of the disclosure are as follows.

(10) For the raw materials, each raw material supplier is requested to provide an analysis table of the raw material composition and a material safety data sheet to confirm that each raw material complies with laws and regulations.

(11) The basic conditions and specifications of the production room include: (1) the raw materials must be dried at 40 to 50 degrees, or choose anhydrous raw materials; (2) The granular raw materials should be ground to ensure that the raw materials can be mixed uniformly; (3) the filling room should be kept at a temperature of 18 to 25 degrees and a relative humidity: 20% to 25% law humidity of production workshop; (4) the production line must meet the specifications of GMP or related operations.

(12) For packaging materials, the hypochlorous acid agent (tablet) should be sealed in an opaque waterproof aluminum foil bag or a moisture-proof bag; this hypochlorous acid agent (tablet) should be sealed in an opaque aluminum foil bag, and the hypochlorous acid agent (tablet) can be sealed with an outer box and film.
For the quality control standards, a pH value and a concentration of the hypochlorous acid should be measured in each lot number of semi-finished products; the pH value of hypochlorous acid should be pH 4 to 6.5, and the concentration of the hypochlorous acid should be 200 ppm or above. When the quality does not meet the requirements, it shall be treated as waste.

(13) It should be noted that related processes must conform to laws and regulations.

(14) The production process includes incoming materials inspection and acceptance, storage, amounting production quantity, and confirmation of the demand/weight of each raw material.

(15) For the production operation program of the novel hypochlorous acid agent of the present invention, the key items are as follows:

(16) They include raw materials drying operation (step A1), granular raw materials grinding operation (step A2), raw materials sieving and screening (step A3), weighing and sequentially mixing by machine (step A4), finished product inspection of hypochlorous acid (step A5), a qualified product of the hypochlorous acid (step A6), filling and loading the qualified product of the hypochlorous acid into an aluminum foil bag or a moisture-proof bag (step A7). Please refer to the flow chart in FIG. 3.

(17) With reference to FIG. 3, the production method of the novel hypochlorous acid agent of the present invention is illustrated as follows:

(18) In step A1, the raw materials are first placed and dried at a temperature of 40 to 50° C. for 4 to 5 hours. After drying, the moisture is measured, and the moisture content of each raw materials shall be 2% for conformity (i.e., the moisture≤2%);

(19) In step A2, the raw materials containing particles is ground to meet the requirements for fine powder, so that the ingredients can be fully mixed;

(20) In step A3, the raw materials after drying are sieved with a 50-80 mesh screen. During the sieving, the temperature of the production room shall be controlled at 18° C.˜25° C. and the relative humidity at 20%˜25% to prevent impurities and particles in the raw materials, so that raw material powders of the compound ratio can be fully mixed to achieve uniform requirements.

(21) In step A4, according to the composition requirements, weigh the chlorine powder, calcium chloride, sodium dihydrogen phosphate or citric acid or ingredients or raw materials with acidic pH, and excipients in order, and then first put the chlorine powder and calcium chloride in a mixer for stirring, then add the sodium dihydrogen phosphate, or citric acid or ingredients or raw materials with acidic pH, and excipients, and after mixing well for 20 to 30 minutes, take out the finished product. Take sample from different mixing locations, and according to product standards of the company, determine whether the pH value of the finished product of the hypochlorous acid is 4 to 6.5 and whether the concentration of the hypochlorous acid reaches the product standard of 200 ppm.

(22) In step A5, the finished product of the hypochlorous acid is tested, and if it is fails, it will be scrapped. Step A6 is to confirm the produced hypochlorous acid is acceptable. Step step A7 is to fill the hypochlorous acid agent into an aluminum foil bag or a moisture-proof bag.

(23) Before production, it should be noted that: 1. The moisture of all raw materials should not exceed 2%; 2. the temperature is 15-25° C., and the relative humidity is 20-25%; 3. The raw materials are added in order, the chlorine powder and the sodium dihydrogen phosphate, or citric acid or ingredients or raw materials with acidic pH must not be directly stirred, and the chlorine powder and calcium chloride must be mixed first and then mixed with other components and stirred. The hypochlorous acid product of the present invention is produced, which is safe and efficient to use, and can be widely used as a disinfectant.

(24) With reference to FIG. 4, the production method for the novel hypochlorous acid tablet of the present invention is as below:

(25) Grind the acceptable hypochlorous acid agent (step A6) into a fine powder and mix it with and mixing the excipient (step B1) for testing the semi-finished product of the hypochlorous acid (step B2). Put the semi-finished product of the hypochlorous acid into the tableting press (step B3); make t hypochlorous acid talets (step B4); conduct hypochlorous acid tablet hardness test (step B5), and the hypochlorous acid tablet conformity test (step B6). Fill the aluminum foil bag with the hypochlorous acid tablets and seal it by the machine (step B7); loadi the hypochlorous acid tablets into finished boxes (step B8); load the boxes of the hypochlorous acid tablets into cartons (step B9); sum up the daily production quantity of the hypochlorous acid tablets and prepare a production report (step B10); ship the hypochlorite tablets (step B11). Please refer to the flow chart in FIG. 4.

(26) In the step B1, grind the acceptable hypochlorous acid agent into the fine powder, and mixed with the excipient to be well and uniform, and determine the moisture content. The moisture content must be 1% or less to be accepted (i.e., the moisture content≤1%).

(27) The acceptable semi-finished hypochlorous acid after being test in the step B2 is put into the tableting press in the step B3, to automatically conduct the tableting (i.e., step B4). During tableting, the moisture of the raw materials is ≤1%, the temperature is 15 to 25° C., and the humidity is 20 to 25%; in the step B5, the tablet is checked and weighed every 10 minutes to prevent the weight of the tablet from being incorrect. After confirming that the tablet is acceptable in the step B6, the hypochlorous acid tablets are packed into the aluminum foil bag and sealed in the step B7. The hypochlorous acid tablets are loaded into the finished box and marked with the lot number and expiration date in the step B8. In the step B9, the finished boxes of the hypochlorous acid tablets are loaded into the cartons and marked with the lot number. In the step B10, the field operator records the lot number of the finished product of the hypochlorous acid tablets daily. Finally, the shipping operation is performed according to the business unit order in the step B11.

(28) In step B5, a hardness check is carried out; 10 pieces are sampled to confirm that the hardness meets the enterprise's quality and hardness standards is acceptable; if it is non-conforming, scrap the product.

(29) In steps B7, B8 and B9, the acceptable semi-finished products are packed into the aluminum foil bag according to the requirements, and marked with the lot number with an automatic inkjet machine, and sealed with a film; every 5 bags are packed in a box, and put with a product manual, then marked with the lot number, production data and the expiration date, and sealed with a film; every 24 boxes are packed into a carton and marked with the lot number.

(30) In step B10, before the finished products are packed into the warehouse, the quality control personnel will check the lot number, product specifications and other information of the packaged product one by one, and verify that they are correct before entering the warehouse.

(31) Similarly, in step B6, samples for each batch of the finished product should be kept for future inspection; each batch of the finished product must be accompanied by a test report.

(32) Before tableting, it should be noted that: 1. the moisture of all raw materials must not exceed 1%; 2. the temperature is 15-25° C., and the relative humidity is 20-25%.

(33) The product of the present invention is produced and operated according to the present production process to produce the novel hypochlorous acid tablet product of the present invention, which is safe, efficient and widely used as a disinfectant tablet.

(34) The novel hypochlorous acid agent (tablet) of the present invention has the functions of disinfection, sterilization, deodorization, water purification and bleaching, safe for people, and can be widely used in swimming pool disinfection, drinking water disinfection, food processing industry, beverage industry, industrial wastewater treatment, aquaculture, daily chemical industry, medical industry, schools, epidemic prevention, hotels, restaurants and large-scale sterilization after floods to prevent infection, and so on. With the the economic development, the living standard is increasing day by day, and the demand for disinfection and sterilization of evolving bacteria and viruses are increasing. The development of the novel hypochlorous acid agent (tablet) will gradually replace traditional chlorine-containing disinfectants, and it will be more widely used in daily sterilization needs, which will benefit national health and environmental well-being.

(35) Where the foregoing is directed to the embodiments of the present invention, other or further embodiments of the present invention can be designed without violating its basic scope, and their basic scope is defined by the following claims. Although the present invention is explained in terms of related preferred embodiments, this does not constitute a limitation on the present invention. It should be noted that skilled persons in the field can construct many other similar embodiments based on the idea of the present invention, which are within the protection scope of the present invention.