PHENYLACETIC ACID DERIVATIVE, USE THEREFOR, AND PRODUCTION INTERMEDIATE THEREOF

Abstract

The present invention provides a compound having an excellent efficacy for controlling pests. According to the present invention, a compound represented by formula (I) [wherein Q represents a group represented by Q1, or a group represented by Q2 (where • represents a binding site to a benzene ring), E represents a C5-C6 cycloalkenyl group and so on, L represents an oxygen atom or NH, a combination of R.sup.1 and n represents a combination where R.sup.1 represents a hydrogen atom, and n is 1, and so on, and R.sup.2 represents a methyl group and so on] or its N-oxide, or agriculturally acceptable salts thereof has an excellent efficacy for controlling pests.

##STR00001##

##STR00002##

##STR00003##

Claims

1. A compound represented by formula (I): ##STR00206## [wherein Q represents a group represented by Q1, or a group represented by Q2 (where ● represents a binding site to a benzene ring), ##STR00207## ##STR00208## E represents a C5-C6 cycloalkenyl group which may be optionally substituted with one or more substituents selected from Group D, a C6-C10 aryl group, a five- to ten-membered aromatic heterocyclic group {the C6-C10 aryl group and the five- to ten-membered aromatic heterocyclic group may be optionally substituted by one or more substituents selected from Group A }, R.sup.7—C≡C—, R.sup.5—O—N═C(R.sup.4)—, R.sup.8—N═C(R.sup.4)—, or R.sup.6O—, L represents an oxygen atom or NH, a combination of R.sup.1 and n represents a combination where R.sup.1 represents a hydrogen atom, and n is 1; or a combination where R.sup.1 represents a C1-C3 chain hydrocarbon group which may be optionally substituted with one or more halogen atoms, a methoxy group, a cyclopropyl group, or a halogen atom, and n is 0, R.sup.2 represents a methyl group, a cyclopropyl group, or a halogen atom, R.sup.4 represents a C1-C3 chain hydrocarbon group which may be optionally substituted with one or more halogen atoms, or a hydrogen atom, R.sup.5 represents a C1-C6 chain hydrocarbon group which may be optionally substituted with one or more substituents selected from Group F, a C3-C6 cycloalkyl group which may be optionally substituted with one or more substituents selected from Group D, a phenyl group, a five- to six- membered aromatic heterocyclic group {the phenyl group and the five- to six- membered aromatic heterocyclic group may be optionally substituted with one or more substituents selected from Group C}, or R.sup.18—CH.sub.2—, R.sup.7 represents a C1-C6 chain hydrocarbon group which may be optionally substituted with one or more substituents selected from Group F, a C3-C6 cycloalkyl group which may be optionally substituted with one or more substituents selected from Group D, or a five- to six- membered aromatic heterocyclic group {the five- to six- membered aromatic heterocyclic group may be optionally substituted with one or more substituents selected from Group C}, R.sup.6 represents a methyl group which is substituted with one or more substituents selected from Group F, a C2-C6 chain hydrocarbon group which may be optionally substituted with one or more substituents selected from Group F, a C3-C4 cycloalkyl group which may be optionally substituted with one or more substituents selected from Group D, or R.sup.13R.sup.4NC(O)—, R.sup.8 and R.sup.13 are identical to or different from each other and represent a C1-C6 chain hydrocarbon group which may be optionally substituted with one or more substituents selected from Group F, a C3-C6 cycloalkyl group which may be optionally substituted with one or more substituents selected from Group D, a phenyl group, a five- to six- membered aromatic heterocyclic group {the phenyl group and the five- to six- membered aromatic heterocyclic group may be optionally substituted with one or more substituents selected from Group C}, or R.sup.10—(CH.sub.2).sub.m—, m is 1 or 2, R.sup.10 and R.sup.18 are identical to or different from each other and represent a phenyl group, or a five- to six- membered aromatic heterocyclic group {the phenyl group and the five- to six- membered aromatic heterocyclic group may be optionally substituted with one or more substituents selected from Group C}, Group A is a group consisting of a C1-C6 chain hydrocarbon group which may be optionally substituted with one or more substituents selected from Group F, a C3-C6 cycloalkyl group which may be optionally substituted with one or more substituents selected from Group D, a C1-C6 alkylthio group which may be optionally substituted with one or more substituents selected from Group F, OR.sup.14, C(O)R.sup.11, C(O)OR.sup.11, NR.sup.11R.sup.9, C(R.sup.9)═NOR.sup.11, a phenyl group, a five- to six- membered aromatic heterocyclic group {the phenyl group, and the five- to six- membered aromatic heterocyclic group may be optionally substituted with one or more substituents selected from Group E}, a halogen atom, a cyano group, and a nitro group, R.sup.9 represents a C1-C3 chain hydrocarbon group which may be optionally substituted with one or more halogen atoms, or a hydrogen atom, R.sup.11 and R.sup.14 are identical to or different from each other and represent a C1-C6 chain hydrocarbon group which may be optionally substituted with one or more substituents selected from Group F, a C3-C6 cycloalkyl group which may be optionally substituted with one or more substituents selected from Group D, a phenyl group, or a five- to six- membered aromatic heterocyclic group {the phenyl group and the five- to six- membered aromatic heterocyclic group may be optionally substituted with one or more substituents selected from Group C}, Group C is a group consisting of a C1-C3 chain hydrocarbon group, a C3-C4 cycloalkyl group, a C1-C3 alkoxy group, and a C1-C3 alkylthio group {the C1-C3 chain hydrocarbon group, the C3-C4 cycloalkyl group, the C1-C3 alkoxy group, and the C1-C3 alkylthio group may be optionally substituted with one or more halogen atoms}, a halogen atom, a cyano group, a nitro group, and a hydroxy group, Group D is a group consisting of a C1-C3 alkyl group which may be optionally substituted with one or more halogen atoms, a halogen atom, and a cyano group, Group E is a group consisting of a C1-C3 chain hydrocarbon group, a C3-C4 cycloalkyl group, a C1-C3 alkoxy group, and C1-C3 alkylthio group {the C3-C4 cycloalkyl group, the C1-C3 alkoxy group, and the C1-C3 alkylthio group may be optionally substituted with one or more halogen atoms}, a halogen atom, a cyano group, a nitro group, and a hydroxy group, and Group F is a group consisting of a C3-C4 cycloalkyl group, a C1-C3 alkoxy group, and a halogen atom] or its N-oxide or agriculturally acceptable salts.

2. The compound according to claim 1 wherein E represents a C5-C6 cycloalkenyl group which may be optionally substituted with one or more substituents selected from Group D, a phenyl group, a five- to six- membered aromatic heterocyclic group {the phenyl group and the five- to six- membered aromatic heterocyclic group may be optionally substituted with one or more substituents selected from Group H}, R.sup.7—C≡C—, R.sup.5—O—N═C(R.sup.4)—, or R.sup.6O—, R.sup.4 represents a C1-C3 alkyl group, or a hydrogen atom, R.sup.5 represents a C1-C6 chain hydrocarbon group which may be optionally substituted with one or more substituents selected from Group F, a C3-C6 cycloalkyl group which may be optionally substituted with one or more halogen atoms, a phenyl group, a five- to six-membered aromatic heterocyclic group {the phenyl group and the five- to six- membered aromatic heterocyclic group may be optionally substituted with one or more substituents selected from Group G}, or R.sup.18—CH.sub.2—, R.sup.6 represents a C2-C6 which may be optionally substituted with one or more substituents selected from Group F, a C3-C4 cycloalkyl group which may be optionally substituted with one or more halogen atoms, or R.sup.13R.sup.4NC(O)—, R.sup.7 represents a C1-C6 chain hydrocarbon group which may be optionally substituted with one or more substituents selected from Group F, or a C3-C6 cycloalkyl group which may be optionally substituted with one or more halogen atoms, R.sup.11 and R.sup.13 are identical to or different from each other and represent a C1-C6 chain hydrocarbon group which may be optionally substituted with one or more substituents selected from Group F, or a C3-C6 cycloalkyl group which may be optionally substituted with one or more halogen atoms, R.sup.14 represents a C1-C6 chain hydrocarbon group which may be optionally substituted with one or more substituents selected from Group F, a C3-C6 cycloalkyl group which may be optionally substituted with one or more halogen atoms, or a phenyl group which may be optionally substituted with one or more substituents selected from Group G, R.sup.18 represents a phenyl group, or a five- to six- membered aromatic heterocyclic group {the phenyl group and the five- to six- membered aromatic heterocyclic group may be optionally substituted with one or more substituents selected from Group G}, Group G is a group consisting of a C1-C3 chain hydrocarbon group, a C1-C3 alkoxy group {the C1-C3 chain hydrocarbon group and the C1-C3 alkoxy group may be optionally substituted with one or more halogen atoms}, a halogen atom, and a cyano group, and Group H is a group consisting of a C1-C6 chain hydrocarbon group which may be optionally substituted with one or more substituents, a C3-C4 cycloalkyl group which may be optionally substituted with one or more halogen atoms, OR.sup.14, a halogen atom, a cyano group, C(R.sup.4)═N—OR.sup.11, a phenyl group, and a five- to six- membered aromatic heterocyclic group {the phenyl group and the five- to six- membered aromatic heterocyclic group may be optionally substituted with one or more substituents selected from Group G}, or its N-oxide or agriculturally acceptable salts.

3. The compound according to claim 2 wherein E represents R.sup.7—C≡C—, R.sup.5—O—N═C(R.sup.4)—, R.sup.6O—,a phenyl group, a pyridyl group, a thienyl group, a furanyl group, a pyrimidinyl group, a thiadiazolyl group, or a pyrazolyl group {the phenyl group, the pyridyl group, the thienyl group, the furanyl group, the pyrimidinyl group, the thiadiazolyl group, and the pyrazolyl group may be optionally substituted with one or more substituents selected from Group I}, R.sup.5 represents a C1-C6 chain hydrocarbon group which may be optionally substituted with one or more substituents selected from Group F, or a C3-C4 cycloalkyl group which may be optionally substituted with one or more halogen atoms, or R.sup.18—CH.sub.2—, R.sup.6 represents a C2-C6 chain hydrocarbon group which may be optionally substituted with one or more halogen atoms, R.sup.7 represents a C1-C6 chain hydrocarbon group which may be optionally substituted with one or more halogen atoms, or a C3-C4 cycloalkyl group which may be optionally substituted with one or more halogen atoms, R.sup.11 represents a C1-C3 alkyl group which may be optionally substituted with one or more halogen atoms, R.sup.14 represents a C1-C6 chain hydrocarbon group which may be optionally substituted with one or more substituents selected from Group F, a C3-C4 cycloalkyl group which may be optionally substituted with one or more halogen atoms, or a phenyl group which may be optionally substituted with one or more substituents selected from Group G, R.sup.18 represents a phenyl group which may be optionally substituted with one or more substituents selected from Group G, and Group I is a group consisting of a C1-C6 chain hydrocarbon group which may be optionally substituted with one or more substituents selected from Group F, a cyclopropyl group, OR.sup.14, a halogen atom, a cyano group, C(R.sup.4)═N—OR.sup.11, a phenyl group, a pyridyl group, and a pyrazolyl group {the phenyl group, the pyridyl group, and the pyrazolyl group may be optionally substituted with one or more substituents selected from Group G}, or its N-oxide or agriculturally acceptable salts.

4. The compound according to claim 2 wherein E represents R.sup.7—C≡C—, a phenyl group, a pyridyl group, a thienyl group, a furanyl group, a thiadiazolyl group, a pyrazolyl group {the phenyl group, the pyridyl group, the thienyl group, the furanyl group, the thiadiazolyl group, and the pyrazolyl group may be optionally substituted with one or more substituents selected from Group J}, or a pyrimidinyl group {the pyrimidinyl group may be optionally substituted with one or more substituents selected from Group K}, R.sup.7 represents a C1-C6 alkyl group which may be optionally substituted with one or more halogen atoms, or a cyclopropyl group, Group J is a group consisting of a C1-C6 chain hydrocarbon group, a C1-C3 alkoxy group {the C1-C6 chain hydrocarbon group and the C1-C3 alkoxy group may be optionally substituted with one or more substituents selected from Group F}, a cyclopropyl group, a halogen atom, a cyano group, C(R.sup.4)═N—OR.sup.11, a phenyl group, a pyridyl group, and a pyrazolyl group {the phenyl group, the pyridyl group, and the pyrazolyl group may be optionally substituted with one or more substituents selected from Group G}, and Group K is a group consisting of a C1-C3 alkyl group which may be optionally substituted with one or more halogen atoms, a phenoxy group which may be optionally substituted with one or more substituents selected from Group G, and a halogen atom, or its N-oxide or agriculturally acceptable salts.

5. The compound according to claim 1 wherein R.sup.1represents a C1-C3 chain hydrocarbon group which may be optionally substituted with one or more halogen atoms, or a halogen atom, and n is 0, or its N-oxide or agriculturally acceptable salts.

6. The compound according to claim 1 wherein Q represents a group represented by Q1, R.sup.1 represents a methyl group, and n is 0, or its N-oxide or agriculturally acceptable salts.

7. An agricultural composition which comprises the compound according to claim 1 or its N-oxide compound or an agriculturally acceptable salt thereof and an inert carrier.

8. A composition which comprises one or more ingredients selected from the group consisting of the following Groups (a), (b), (c) and (d) and the compound according to claim 1 or its N-oxide compound or agriculturally acceptable salts: Group (a): a group consisting of insecticidal ingredients, miticidal ingredients, and nematicidal ingredients; Group (b): fungicidal ingredients : Group (c): plant growth modulating ingredients; and Group (d): repellent ingredients.

9. A method for controlling pests which comprises applying an effective amount of the compound according to claim 1 or its N-oxide compound or an agriculturally acceptable salt thereof to a plant or soil.

10. A method for controlling soybean rust fungus having an amino acid substitution of F129L on mitochondrial cytochrome b protein by applying an effective amount of the compound according to claim 1 or its N-oxide compound or an agriculturally acceptable salt thereof to soybean or soils where soybean grows.

11. (canceled)

12. A seed or vegetative reproductive organ carrying an effective amount of the compound according to claim 1 or its N-oxide thereof, .

13. A compound represented by formula (II): ##STR00209## [wherein a combination of Q and E.sup.B represents a combination where Q represents a group represented by Q1, and E.sup.B represents R.sup.12C(O)—, R.sup.12C(═N—OH)—, or a halogen atom, or, a combination where Q represents a group represented by Q2, and E.sup.B represents R.sup.12C(O)—, R.sup.12C(═N—OH)—, a bromine atom, or an iodine atom, each of the group represented by Q1 and the group represented by Q2 represents the following group (where ● represents a binding site to a benzene ring), ##STR00210## ##STR00211## L represents an oxygen atom or NH, R.sup.1 represents a C1-C3 chain hydrocarbon group which may be optionally substituted with one or more halogen atoms, a methoxy group, a cyclopropyl group, or a halogen atom, and R.sup.12 represents a C1-C3 alkyl group].

Description

EXAMPLES

[0660] Hereinafter, the present invention is explained in more detail by Preparation Examples, Reference Preparation Examples, Formulation Examples, and Test Examples, however, the present invention should not be limited to only the these Examples.

[0661] As used herein, Me represents methyl group, Et represents ethyl group, Pr represents propyl group, i-Pr represents isopropyl group, Bu represents butyl group, i-Bu represents isobutyl group, t-Bu represents t-butyl group, Pen represents pentyl group, c-Pr represents cyclopropyl group, c-Bu represents cyclobutyl group, c-Pen represents cyclopentyl group, c-Hex represents cyclohexyl group, and Ph represents phenyl group.

[0662] Firstly, Preparation examples of the compound of the present invention are described.

[0663] When a physical property of a compound is measured by a liquid chromatography / mass spectrometry analysis (hereinafter, referred to as LCMS), a measured molecular ion value [M + H].sup.+ or [M—H].sup.— and a retention time (hereinafter, referred to as RT) is described. The measured condition for liquid chromatography (hereinafter, referred to as LC) and mass spectrometry (hereinafter, referred to as MS) is described below.

LC Condition

[0664] Column: L-column2 ODS, inner diameter 4.6 mm, length 30 m m, particle size 3 .Math.m (Chemicals Evaluation and Research Institute, Japan)

[0665] UV measurement wavelength: 254 nm

[0666] Mobile phase: A solution: 0.1 % aqueous formic acid solution,

[0667] B solution: 0.1 % formic acid in acetonitrile

[0668] Flow Rate: 2.0 mL/min

[0669] Pump: LC-20AD (manufacturing SHIMAZU) 2 umps (high pressure gradient)

[0670] Gradient condition: The following concentration gradient shown in [Table LC1] is liquid-transferred.

TABLE-US-00001 Time (min) A solution (%) B solution (%) 0.01 90 10 2.00 0 100 4.00 0 100 4.01 90 10

MS Condition

[0671] Detector: LCMS-2020 (manufacturing SHIMADZU)

[0672] Ionization method: DUIS

Reference Prepration Example 1

[0673] To a mixture of methyl 2-(5-bromo-2-methylphenyl)acetate (which was prepared by the method described in WO 2019/016269 A1) 19.4 g, methyl formate 14.7 mL, and dimethoxyethane 150 mL was added tert-butoxy potassium 19.7 g at 0° C., and the mixture was stirred at room temperature for 1 hour. To the resulting mixture was added 1 N hydrochloric acid, and the mixture was extracted with MTBE. The resulting mixture was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. To the resulting residue was added DMF 100 mL, and the mixture was stirred, and thereto were added potassium carbonate 9.9 g, and dimethyl sulfate 6.8 mL at 0° C. successively, and the mixture was stirred at room temperature for 5 hours. Water was added to the resulting mixture, and the mixture was extracted with MTBE. The resulting organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting residue was subjected to a silica gel column chromatography (ethyl acetate : hexane= 1 : 4) to obtain the intermediate compound 1 represented by the following formula 14.2 g.

##STR00062##

[0674] Intermediate compound 1: .sup.1H-NMR (CDCl.sub.3) δ: 7.56 (1 H, s), 7.33 (1 H, dd), 7.24 (1 H, d), 7.09 (1 H, d), 3.84 (3 H, s), 3.70 (3 H, s), 2.12 (3 H, s).

Reference Preparation Example 1-1

[0675] The compounds which were prepared according to the Reference Prepration Exmaple 1 and their physical property value are shown below.

##STR00063##

[0676] Intermediate compound 1-2: .sup.1H-NMR (CDCl.sub.3) δ: 7.57 (1 H, s), 7.38-7.35 (2 H, m), 7.29-7.26 (1 H, m), 3.87 (3 H, s), 3.72 (3 H, s) .

Reference Preparation Example 1-2

[0677] The compounds which can be prepared according to the Reference Prepration Exmaple 1 are shown below.

[0678] A compound represented by formula (M1-a):

##STR00064##

wherein a combination of R.sup.1, R.sup.22 and R.sup.23 represent any combinations described in [Table A1].

TABLE-US-00002 Intermediate compound R.sup.1 R.sup.22 R.sup.23 1-3 F H H 1-5 Et H H 1-6 c-Pr H H 1-7 H Cl H 1-9 H H Cl

Reference Preparation Example 1-3

[0679] The compounds which were prepared according to the Reference Preparation Example 1 and their physical property value are shown below.

[0680] The compounds represented by formula (M1-a) wherein a combination of R.sup.1, R.sup.22 and R.sup.23 represent any combinations described in [Table A14].

TABLE-US-00003 Intermediate compound R.sup.1 R.sup.22 R.sup.23 1-4 OMe H H 1-8 H Me H 1-10 H H Me

[0681] Intermediate compound 1-4: : .sup.1H-NMR (CDCl.sub.3) δ: 7.50 (1 H, s), 7.37 (1 H, dd), 7.28 (1 H, d), 6.78 (1 H, d), 3.83 (3 H, s), 3.76 (3 H, s), 3.69 (3 H, s). [0682] Intermediate compound 1-8: .sup.1H-NMR (CDCl.sub.3) δ: 7.54 (1 H, s), 7.51 (1 H, s), 7.23-7.15 (2 H, m), 3.86 (3 H, s), 3.74 (3 H, s), 2.38 (3 H, s). [0683] Intermediate compound 1-10: .sup.1H-NMR (CDCl.sub.3) δ: 7.54 (1 H, s), 7.27 (1 H, s), 7.24 (1 H, s), 7.05 (1 H, s), 3.86 (3 H, s), 3.74 (3 H, s), 2.33 (3 H, s).

Reference Preparation Example 2

[0684] A mixture of 3.3 g of the intermediate compound 1, bis(pinacolato)diboron 4.7 g, [1,1′-bis(diphenylphosphino)ferrocene]palladium (II) dichloride 0.85 g, tripotassium phosphate 7.4 g, and dimethoxyethane 30 mL was stirred at 80° C. for 10 hours. The resulting mixture was cooled to room temperature, and concentrated under reduced pressure. The resulting residue was subjected to a silica gel column chromatography (ethyl acetate : hexane= 1 : 4) to obtain the intermediate compound 2 represented by the following formula.

##STR00065##

[0685] Intermediate compound 2: .sup.1H-NMR (CDCl.sub.3) δ: 7.67 (1 H, dd), 7.55 (1 H, s), 7.54 (1 H, d), 7.23 (1 H, d), 3.80 (3 H, s), 3.68 (3 H, s), 2.19 (3 H, s), 1.32 (12 H, s).

Reference Preparation Example 3

[0686] A mixture of 5.0 g of the intermediate compound 1, bis(triphenylphosphine)palladium(II) dichloride 0.61 g, tributyl(1-ethoxyvinyl)tin 7.0 mL, and 1,4-dioxane 30 mL was stirred at 100° C. for 5 hours. To the resulting mixture was added 1 N hydrochloric acid, and the mixture was stirred at room temperature for 30 minutes. The resulting mixture was concentrated under reduced pressure and extracted with ethyl acetate. The resulting organic layers were concentrated under reduced pressure and the residue was subjected to a silica gel column chromatography (ethyl acetate : hexane= 2 : 3) to obtain the intermediate compound 3 represented by the following formula 3.41 g.

##STR00066##

[0687] Intermediate compound 3: .sup.1H-NMR (CDCl.sub.3) δ: 7.82 (1 H, dd), 7.71 (1 H, d), 7.60 (1 H, s), 7.31 (1 H, d), 3.84 (3 H, s), 3.71 (3 H, s), 2.57 (3 H, s), 2.24 (3 H, s).

Reference Preparation Example 4

[0688] To a mixture of 1.0 g of the intermediate compound 3, hydroxylamine hydrochloride salt 0.28 g, and methanol 12 mL was added pyridine 0.64 mL at 0° C., and the mixture was stirred at room temperature for 2.5 hours. The resulting mixture was diluted with ethyl acetate, and washed with water and saturated brine successively. The resulting organic layers were dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The precipitated out solids were washed with a mixed solvent of ethyl acetate and hexane (2 : 3) to obtain the intermediate compound 4 represented by the following formula 0.91 g.

##STR00067##

[0689] Intermediate compound 4: .sup.1—H—NMR (CDCl.sub.3) δ: 8.78 (1 H, s), 7.59 (1 H, s), 7.48 (1 H, dd), 7.38 (1 H, d), 7.23 (1 H, d), 3.83 (3 H, s), 3.70 (3 H, s), 2.26 (3 H, s), 2.19 (3 H, s).

Reference Preparation Example 4-1

[0690] The compounds which were prepared according to the Reference Preparation Example 4 and their physical property value are shown below.

##STR00068##

[0691] Intermediate compound 4-2: .sup.1H—NMR (CDCl.sub.3) δ: 9.01 (1 H, br s), 8.11 (1 H, s), 7.59 (1 H, s), 7.45 (1 H, dd), 7.31 (1 H, d), 7.23 (1 H, d), 3.81 (3 H, s), 3.70 (3 H, s), 2.19 (3 H, s).

Reference Preparation Example 5

[0692] To a mixture of methyl 2-(5-bromo-2-methylphenyl)acetate (which was prepared by the method described in WO 2019/016269 A1) 20.0 g, isoamyl nitrite 13.2 mL, and THF 160 mL was added sodium methoxide (28 % in methanol) 25.4 mL, and the mixture was stirred at room temperature for 7 hours. To the resulting mixture was added 1N hydrochloric acid, and the mixture was extracted with ethyl acetate. The resulting organic layers were washed with water and saturated brine successively, dried over sodium sulfate, and concentrated under reduced pressure. The resulting residue was subjected to a silica gel column chromatography (ethyl acetate : hexane = 1:4) to obtain the intermediate compound 5 represented by the following formula 6.51 g.

##STR00069##

[0693] Intermediate compound 5: .sup.1H—NMR (CDCl.sub.3) δ: 9.25 (1 H, s), 7.45 (1 H, dd), 7.29 (1 H, d), 7.15 (1 H, d), 3.87 (3 H, s), 2.17 (3 H, s) .

Reference Preparation Example 6

[0694] To a mixture of 6.51 g of the intermediate compound 5, potassium carbonate 4.0 g, and DMF 60 mL was added dimethyl sulfate 2.7 mL at 0° C., and the mixture was stirred at room temperature for 2 hours. To the resulting mixture was added aqueous ammonium chloride solution, and the mixture was extracted with MTBE. The resulting organic layers were washed with water and saturated brine successively, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residue was subjected to a silica gel column chromatography (ethyl acetate : hexane = 1:9) to obtain the intermediate compound 6 represented by the following formula 4.83 g.

##STR00070##

[0695] Intermediate compound 6: .sup.1H—NMR (CDCl.sub.3 δ: 7.42 (1 H, dd), 7.23 (1 H, d), 7.12 (1 H, d), 4.06 (3 H, s), 3.88 (3 H, s), 2.13 (3 H, s).

Reference Preparation Example 7

[0696] To a mixture of 2.0 g of the intermediate compound 6, and methanol 20 mL was added methylamine (9.8 M in methanol) 1.2 mL, and the mixture was stirred at room temperature overnight. Water was added to the resulting mixture, and the mixture was extracted with ethyl acetate. The resulting organic layers were dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residue was subjected to a silica gel column chromatography to obtain the intermediate compound represented 7 by the following formula 1.99 g.

##STR00071##

[0697] Intermediate compound 7: .sup.1H-NMR (CDCl.sub.3) δ: 7.40 (1 H, dd), 7.22 (1 H, d), 7.10 (1 H, d), 6.78 (1 H, br s), 3.97 (3 H, s), 2.94 (3 H, d), 2.12 (3 H, s).

Reference Preparation Example 8

[0698] A mixture of 4.5 g of the intermediate compound 2, methachloro perbenzoic acid 4.0 g, acetonitrile 20 mL, and ethanol 20 mL, and water 20 mL was stirred at room temperature for 15 minutes. To the resulting mixture was added aqueous sodium thiosulfate solution and aqueous sodium hydrogencarbonate solution, and the mixture was stirred at room temperature for 30 minutes. The resulting mixture was concentrated under reduced pressure and extracted with ethyl acetate. The resulting organic layers were concentrated under reduced pressure to obtain the intermediate compound 8 represented by the following formula 4.5 g.

##STR00072##

[0699] Intermediate compound 8: .sup.1H—NMR (CDCl.sub.3) δ: 7.54 (1 H, s), 7.08 (1 H, d), 6.71 (1 H, dd), 6.60 (1 H, d), 3.83 (3 H, s), 3.70 (3 H, s), 2.09 (3 H, s).

Preparation Example 1

[0700] A mixture of 0.30 g of the intermediate compound 1, PdCl.sub.2 (PPh.sub.3).sub.2 0.04 g, 1-pentyne 0.29 g, tetrabutyl ammonium fluoride (1 mol/L in THF) 3.2 mL and THF 3 mL was stirred at 80° C. under nitrogen atmosphere for 3 hours. To the resulting mixture was added aqueous saturated sodium bicarbonate solution, and the mixture was extracted with ethyl acetate. The resulting organic layers were dried over sodium sulfate, and concentrated under reduced pressure. The residue was subjected to a silica gel column chromatography (ethyl acetate : hexane = 1:2) to obtain the compound of the present invention 1-3 represented by the following formula 0.22 g.

##STR00073##

[0701] Compound of the present invention 1-3: .sup.1H—NMR (CDCl.sub.3) δ: 7.55 (1 H, s), 7.25-7.23 (1 H, m), 7.15-7.12 (2 H, m), 3.82 (3 H, s), 3.69 (3 H, s), 2.36 (2 H, t), 2.15 (3 H, s), 1.65-1.58 (2 H, m), 1.03 (3 H, t).

Preparation Example 1-1

[0702] The compounds which were prepared according to the Preparation Example 1 and their physical property value are shown below.

[0703] A compound of the present invention 1-2 represented by formula (1a):

##STR00074##

wherein R.sup.7 represents a substituents described below.

[0704] Compound of the present invention 1-2 (R.sup.7 — c—Pr) :.sup.1H—NMR (CDCl.sub.3) δ: 7.54 (1 H, s), 7.23-7.21 (1 H, m), 7.13-7.10 (2 H, m), 3.81 (3 H, s), 3.68 (3 H, s), 2.14 (3 H, s), 1.46-1.39 (1 H, m), 0.85-0.75 (4 H, m).

Preparation Example 1-2

[0705] The compounds which were prepared according to the Preparation Example 1 and their physical property value are shown below.

[0706] A compound represented by formula (2a):

##STR00075##

wherein a combination of R.sup.7 and L represents any combinations described in [Table A9].

TABLE-US-00004 Compound of the present invention R.sup.7 L 1-4 c-Pr O 1-5 t-Bu O 1-6 c-Pr NH 1-7 t-Bu NH

[0707] Compound of the present invention 1-4: .sup.1H—NMR (CDCl.sub.3) δ: 7.30 (1 H, dd), 7.14 (1 H, d), 7.12 (1 H, d), 4.04 (3 H, s), 3.86 (3 H, s), 2.15 (3 H, s), 1.46-1.38 (1 H, m), 0.88-0.81 (2 H, m), 0.80-0.75 (2 H, m).

[0708] Compound of the present invention 1-5: .sup.1H—NMR (CDCl.sub.3) δ: 7.31 (1 H, dd), 7.14 (1 H, d), 7.12 (1 H, d), 4.04 (3 H, s), 3.86 (3 H, s), 2.15 (3 H, s), 1.29 (9 H, s).

[0709] Compound of the present invention 1-6: .sup.1H—NMR (CDCl.sub.3) δ: 7.28 (1 H, dd), 7.13 (1 H, d), 7.11 (1 H, d), 6.71 (1 H, br s), 3.95 (3 H, s), 2.92 (3 H, d), 2.15 (3 H, s), 1.45-1.36 (1 H, m), 0.87-0.79 (2 H, m), 0.79-0.72 (2 H, m).

[0710] Compound of the present invention 1-7: .sup.1H—NMR (CDCl.sub.3) δ: 7.29 (1 H, dd), 7.14-7.11 (2 H, m), 6.72 (1 H, br s), 3.95 (3 H, s), 2.92 (3 H, d), 2.15 (3 H, s), 1.28 (9 H, s).

[0711] A compound represented by formula (3a):

##STR00076##

wherein a combination of R.sup.1, R.sup.7, R.sup.22 and R.sup.23 represents any combinations described in [Table A11].

TABLE-US-00005 Compound of the present invention R.sup.1 R.sup.7 R22 R.sup.23 1-1 Cl c-Pr H H 1-8 Cl t-Bu H H 1-9 OMe c-Pr H H 1-10 OMe t-Bu H H 1-11 H c-Pr H Me 1-12 H t-Bu H Me 1-13 H c-Pr Me H

[0712] Compound of the present invention 1-1: .sup.1H—NMR (CDCl.sub.3) δ: 7.55 (1 H, s), 7.31-7.28 (1 H, m), 7.24-7.21 (2 H, m), 3.84 (3 H, s), 3.69 (3 H, s), 1.46-1.38 (1 H, m), 0.89-0.75 (4 H, m).

[0713] Compound of the present invention 1-8: .sup.1H—NMR (CDCl.sub.3) δ: 7.55 (1 H, s), 7.32-7.28 (1 H, m), 7.25-7.22 (2 H, m), 3.84 (3 H, s), 3.69 (3 H, s), 1.29 (9 H, s).

[0714] Compound of the present invention 1-9: .sup.1H—NMR (CDCl.sub.3) δ: 7.49 (1 H, s), 7.31 (1 H, dd), 7.19 (1 H, d), 6.80 (1 H, d), 3.81 (3 H, s), 3.77 (3 H, s), 3.67 (3 H, s), 1.45-1.38 (1 H, m), 0.85-0.74 (4 H, m).

[0715] Compound of the present invention 1-10: .sup.1H—NMR (CDCl.sub.3) δ: 7.50 (1 H, s), 7.31 (1 H, dd), 7.19 (1 H, d), 6.80 (1 H, d), 3.81 (3 H, s), 3.77 (3 H, s), 3.67 (3 H, s), 1.29 (9 H, s).

[0716] Compound of the present invention 1-11: .sup.1H—NMR (CDCl.sub.3) δ: 7.52 (1 H, s), 7.13 (1 H, s), 7.11 (1 H, s), 7.01 (1 H, s), 3.84 (3 H, s), 3.72 (3 H, s), 2.30 (3 H, s), 1.47-1.39 (1 H, m), 0.87-0.81 (2 H, m), 0.81-0.75 (2 H, m).

[0717] Compound of the present invention 1-12: .sup.1H—NMR (CDCl.sub.3) δ: 7.53 (1 H, s), 7.14-7.11 (2 H, m), 7.01-6.98 (1 H, m), 3.84 (3 H, s), 3.72 (3 H, s), 2.30 (3 H, s), 1.29 (9 H, s).

[0718] Compound of the present invention 1-13: .sup.1H—NMR (CDCl.sub.3) δ: 7.52 (1 H, s), 7.30 (1 H, d), 7.17-7.07 (2 H, m), 3.84 (3 H, s), 3.72 (3 H, s), 2.37 (3 H, s), 1.52-1.43 (1 H, m), 0.90-0.83 (2 H, m), 0.82-0.75 (2 H, m).

Preparation Example 2

[0719] A mixture of 0.50 g of the intermediate compound 1, 3-acetylphenylboronic acid 0.43 g, [1,1′-bis(diphenylphosphino)ferrocene]palladium (II) dichloride 0.13 g, tripotassium phosphate 1.12 g, dimethoxyethane 10 mL and water 0.1 mL was stirred at 80° C. under nitrogen atmosphere for 5 hours. The resulting mixture was cooled to room temperature, and then concentrated under reduced pressure. The residue was subjected to a silica gel column chromatography (ethyl acetate : hexane = 1:2) obtain the compound of the present invention 2-1 by the following formula 0.55 g.

##STR00077##

[0720] Compound of the present invention 2-1: .sup.1H—NMR (CDCl.sub.3) δ: 8.17 (1 H, t), 7.90 (1 H, dq), 7.79 (1 H, dq,), 7.62 (1 H, s), 7.53-7.48 (2 H, m), 7.38 (1 H, d), 7.33 (1 H, d), 3.85 (3 H, s), 3.73 (3 H, s), 2.65 (3 H, s), 2.24 (3 H, s).

Preparation Example 2-1

[0721] The compounds which were prepared according to the Preparation Example 2 and their physical property value are shown below.

[0722] A compound represented by formula (Ib):

##STR00078##

wherein a combination of R.sup.1, R.sup.24, R.sup.25, R.sup.26, R.sup.27, and R.sup.28 represents any combinations described in [Table A2].

TABLE-US-00006 Compound of the present invention R.sup.1 R.sup.24 R.sup.25 R.sup.26 R.sup.27 R.sup.28 2-2 Me H H CF.sub.3 H H 2-3 Me H H H H H 2-4 Me F H H F H 2-5 Me H F H F H 2-6 Me H F F F H 2-7 Me F H H H H 2-8 Me H F H H H 2-9 Me H H OMe H H 2-10 Me F H H H F 2-11 Me H H F H H 2-12 Me H H Cl H H 2-13 Me H H Me H H 2-14 Me H CF.sub.3 H H H 2-15 Me H Cl H H H 2-16 Me H CF.sub.3 H H F 2-17 Me H Cl H H F 2-18 Me H CN H H H 2-19 Me H C(═NOMe)Me H H H 2-20 Cl H H H H H 2-21 Cl F H H H H 2-22 Me F F H H H 2-23 Me F H H H OMe 2-24 Me F H H H Cl

[0723] Compound of the present invention 2-2: .sup.1H—NMR (CDCl.sub.3) δ: 7.70-7.64 (4 H, m), 7.62 (1 H, s), 7.47 (1 H), 7.36-7.32 (2 H, m), 3.85 (3 H, s), 3.73 (3 H, s), 2.24 (3 H, s).

[0724] Compound of the present invention 2-3: .sup.1H—NMR (CDCl.sub.3) δ: 7.61 (1 H, s), 7.60-7.56 (2 H, m), 7.47-7.39 (3 H, m), 7.35-7.29 (3 H, m), 3.84 (3 H, s), 3.72 (3 H, s), 2.22 (3 H, s).

[0725] Compound of the present invention 2-4: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1 H, s), 7.41 (1 H, dt), 7.33-7.29 (2 H, m) , 7.17-7.13 (1 H, m), 7.10-7.04 (1 H, m), 7.00-6.92 (1 H, m), 3.85 (3 H, s), 3.72 (3 H, s), 2.23 (3 H, s).

[0726] Compound of the present invention 2-5: .sup.1H—NMR (CDCl.sub.3) δ: 7.61 (1 H, s), 7.41 (1 H, dd), 7.32-7.30 (2 H, m), 7.12-7.08 (2 H, m), 6.79-6.72 (1 H, m), 3.85 (3 H, s), 3.72 (3 H, s), 2.22 (3 H, s) .

[0727] Compound of the present invention 2-6: .sup.1H—NMR (CDCl.sub.3) δ: 7.61 (1 H, s), 7.36 (1 H, dd), 7.32-7.30 (1 H, m), 7.26-7.25 (1 H, m), 7.18 (2 H, dd), 3.86 (3 H, s), 3.73 (3 H, s), 2.23 (3 H, s).

[0728] Compound of the present invention 2-7: .sup.1H—NMR (CDCl.sub.3)δ: 7.60 (1 H, s), 7.47-7.42 (2 H, m), 7.31-7.25 (3 H, m), 7.20-7.10 (2 H, m), 3.84 (3 H, s), 3.72 (3 H, s), 2.23 (3 H, s).

[0729] Compound of the present invention 2-8: .sup.1H—NMR (CDCl.sub.3) δ: 7.61 (1 H, s), 7.44 (1 H, dd), 7.37-7.29 (5 H, m), 7.02-6.97 (1 H, m), 3.85 (3 H, s), 3.72 (3 H, s), 2.22 (3 H, s).

[0730] Compound of the present invention 2-9: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1 H, s), 7.53-7.49 (2 H, m), 7.41 (1 H, dd), 7.30 (1 H, d), 7.28-7.26 (1 H, m), 6.97-6.93 (2 H, m), 3.84 (3 H, s), 3.83 (3 H, s), 3.72 (3 H, s), 2.21 (3 H, s) .

[0731] Compound of the present invention 2-10: .sup.1H—NMR (CDCl.sub.3) δ: 7.59 (1 H, s), 7.35-7.30 (2 H, m), 7.27-7.19 (2 H, m), 6.99-6.91 (2 H, m), 3.82 (3 H, s), 3.71 (3 H, s), 2.23 (3 H, s).

[0732] Compound of the present invention 2-11: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1 H, s), 7.54-7.51 (2 H, m), 7.40 (1 H, dd), 7.29-7.27 (2 H, m), 7.11-7.06 (2 H, m), 3.83 (3 H, s), 3.71 (3 H, s), 2.21 (3 H, s).

[0733] Compound of the present invention 2-12: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1 H, s), 7.51-7.48 (2 H, m), 7.42-7.27 (5 H, m), 3.81 (3 H, s), 3.71 (3 H, s), 2.21 (3 H, s).

[0734] Compound of the present invention 2-13: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1 H, s), 7.49-7.43 (3 H, m), 7.33-7.21 (4 H, m), 3.83 (3 H, s), 3.71 (3 H, s), 2.38 (3 H, s), 2.21 (3 H, s).

[0735] Compound of the present invention 2-14: .sup.1H—NMR (CDCl.sub.3) δ: 7.82 (1 H, s), 7.76 (1 H, d), 7.62 (1 H, s), 7.57-7.50 (2 H, m), 7.46 (1 H, dd), 7.35-7.32 (2 H, m), 3.85 (3 H, s), 3.73 (3 H, s), 2.24 (3 H, s).

[0736] Compound of the present invention 2-15: .sup.1H—NMR (CDCl.sub.3) δ: 7.61 (1 H, s), 7.56 (1 H, t), 7.47-7.42 (2 H, m), 7.35-7.26 (4 H, m), 3.84 (3 H, s), 3.72 (3 H, s), 2.22 (3 H, s).

[0737] Compound of the present invention 2-16: .sup.1H—NMR (CDCl.sub.3) δ: 7.72 (1 H, d), 7.61 (1 H, s), 7.57-7.53 (1 H, m), 7.43 (1 H, d), 7.34-7.30 (2 H, m), 7.23-7.21 (1 H, m), 3.85 (3 H, s), 3.72 (3 H, s), 2.24 (3 H, s).

[0738] Compound of the present invention 2-17: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1 H, s), 7.44-7.39 (2 H, m), 7.31-7.28 (2 H, m), 7.25-7.21 (1 H, m), 7.09-7.04 (1 H, m), 3.85 (3 H, s), 3.72 (3 H, s), 2.23 (3 H, s).

[0739] Compound of the present invention 2-18: .sup.1H—NMR (CDCl.sub.3) δ: 7.86 (1 H, t), 7.81 (1 H, dq), 7.62 (1 H, s), 7.59 (1 H, dt), 7.51 (1 H, t), 7.43 (1 H, dd), 7.34-7.32 (2 H, m), 3.86 (3 H, s), 3.73 (3 H, s), 2.24 (3 H, s).

[0740] Compound of the present invention 2-19: .sup.1H—NMR (CDCl.sub.3) δ: 7.83 (1 H, t), 7.61 (1 H, s), 7.60-7.55 (2 H, m), 7.47 (1 H, dd), 7.40 (1 H, t), 7.35 (1 H, d), 7.30 (1 H, d), 4.01 (3 H, s), 3.83 (3 H, s), 3.72 (3 H, s), 2.26 (3 H, s), 2.23 (3 H, s).

[0741] Compound of the present invention 2-20: .sup.1H—NMR (CDCl.sub.3) δ: 7.61 (1 H, s), 7.58-7.55 (2 H, m), 7.48-7.32 (6 H, m), 3.86 (3 H, s), 3.73 (3 H, s).

[0742] Compound of the present invention 2-21: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1 H, s), 7.50-7.41 (4 H, m), 7.34-7.29 (1 H, m), 7.22-7.12 (2 H, m), 3.87 (3 H, s), 3.73 (3 H, s).

[0743] Compound of the present invention 2-22: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1 H, s), 7.42 (1 H, dt), 7.32-7.30 (2 H, m), 7.22-7.18 (1 H, m), 7.12-7.08 (2 H, m), 3.85 (3 H, s), 3.72 (3 H, s), 2.23 (3 H, s).

[0744] Compound of the present invention 2-23: .sup.1H—NMR (CDCl.sub.3) δ: 7.58 (1 H, s), 7.29-7.28 (2 H, m), 7.24-7.19 (2 H, m), 6.79-6.74 (2 H, m), 3.83 (3 H, s), 3.77 (3 H, s), 3.71 (3 H, s), 2.22 (3 H, s).

[0745] Compound of the present invention 2-24: .sup.1H—NMR (CDCl.sub.3) δ: 7.59 (1 H, s), 7.34-7.28 (2 H, m), 7.25-7.20 (2 H, m), 7.15-7.14 (1 H, m), 7.08-7.03 (1 H, m), 3.84 (3 H, s), 3.71 (3 H, s), 2.25 (3 H, s).

[0746] A compound represented by formula (1c):

##STR00079##

wherein E represents a substituent described in [Table A3].

TABLE-US-00007 Compound of the present invention E 3-1 [00080] 3-2 [00081] 3-3 [00082] 3-4 [00083] 3-5 [00084] 3-6 [00085] 3-7 [00086]

[0747] Compound of the present invention 3-1: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1 H, s), 7.46 (1 H, dd), 7.35 (1 H, d,), 7.25-7.22 (3 H, m), 7.05 (1 H, dd), 3.84 (3 H, s), 3.71 (3 H, s), 2.19 (3 H, s). the compound of the present invention 3-2 : .sup.1H—NMR (CDCl.sub.3) δ: 7.59 (1 H, s), 7.39 (1 H, dd), 7.29 (1 H, d), 7.20 (1 H, d), 7.04 (1 H, d), 6.70-6.68 (1 H, m), 3.83 (3 H, s), 3.71 (3 H, s), 2.49 (3 H, d), 2.17 (3 H, s).

[0748] Compound of the present invention 3-3: .sup.1H—NMR (CDCl.sub.3) δ: 7.59 (1 H, s), 7.35 (1 H, dd), 7.25-7.21 (2 H, m), 7.01 (1 H, d), 6.85 (1 H, d), 3.84 (3 H, s), 3.71 (3 H, s), 2.18 (3 H, s).

[0749] Compound of the present invention 3-4: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1H, s), 7.45 (1 H, dd), 7.40-7.39 (1 H, m), 7.37-7.34 (3 H, m), 7.26-7.24 (1 H, m), 3.84 (3 H, s), 3.71 (3 H, s), 2.20 (3 H, s) .

[0750] Compound of the present invention 3-5: .sup.1H—NMR (CDCl.sub.3) δ: 7.59 (1 H, s), 7.44 (1 H, dd), 7.33 (1 H, d), 7.29 (1 H, d), 7.11 (1 H, d), 7.05 (1 H, d), 3.84 (3 H, s), 3.72 (3 H, s), 2.22 (3 H, s).

[0751] Compound of the present invention 3-6: .sup.1H—NMR (CDCl.sub.3) δ: 7.59 (1 H, s), 7.52 (1 H, dd), 7.43-7.42 (2 H, m), 7.26-7.23 (1 H, m), 6.58 (1 H, d), 6.44 (1 H, dd), 3.83 (3 H, s), 3.71 (3 H, s), 2.19 (3 H, s).

[0752] Compound of the present invention 3-7: .sup.1H—NMR (CDCl.sub.3) δ: 7.69-7.68 (1 H, m), 7.59 (1 H, s), 7.45-7.44 (1 H, m), 7.34 (1 H, dd), 7.24-7.22 (2 H, m), 6.68-6.67 (1 H, m), 3.83 (3 H, s), 3.71 (3 H, s), 2.19 (3 H, s).

Preparation Example 2-2

[0753] The compounds which can be prepared according to the Preparation Example 2 are shown below.

[0754] A compound represented by formula (1b) wherein a combination of R.sup.1, R.sup.24, R.sup.25, R.sup.26, R.sup.27, and R.sup.28 represents any combinations described in [Table A10].

TABLE-US-00008 Compound of the present invention R.sup.1 R.sup.24 R.sup.25 R.sup.2.sup.6 R.sup.27 R.sup.28 2-28 Me OMe H H H H 2-29 Me Me H H H H 2-30 Me H c-Pr H H H 2-31 Me H OPh H H H

Preparation Example 2-3

[0755] The compounds which were prepared according to the Preparation Example 2 and their physical property value are shown below.

[0756] A compound represented by formula (1b) wherein a combination of R.sup.1, R.sup.24, R.sup.25, R.sup.26, R.sup.27, and R.sup.28 represents any combinations described in [Table A12].

TABLE-US-00009 Compound of the present invention R.sup.1 R.sup.24 R.sup.25 R.sup.26 R.sup.27 R.sup.28 2-25 Me F F H H F 2-26 Me F F H F F 2-27 Me F F H F H 2-32 Me H F F H H 2-33 Me F H F H H 2-34 Me F F F H H 2-35 Me F F F F F 2-36 Cl H H F H H 2-37 Cl H Cl H H H 2-38 Cl H F H H H 2-39 OMe H H F H H 2-40 OMe F H H H H 2-43 Me H OMe H H H

[0757] Compound of the present invention 2-25: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1 H, s), 7.33 (2 H, s), 7.24 (1 H, s), 7.12-7.04 (1 H, m), 6.92-6.86 (1 H, m), 3.85 (3 H, s), 3.72 (3 H, s), 2.24 (3 H, s).

[0758] Compound of the present invention 2-26: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1 H, s), 7.36-7.33 (2 H, m), 7.24 (1 H, s), 7.07-6.98 (1 H, m), 3.85 (3 H, s), 3.72 (3 H, s), 2.25 (3 H, s).

[0759] Compound of the present invention 2-27: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1 H, s), 7.40 (1 H, d), 7.33-7.25 (2 H, m), 6.97-6.84 (2 H, m), 3.85 (3 H, s), 3.72 (3 H, s), 2.24 (3 H, s).

[0760] Compound of the present invention 2-32: .sup.1H—NMR (CDCl.sub.3) δ: 7.61 (1 H, s), 7.41-7.34 (2 H, m), 7.31-7.26 (3 H, m), 7.22-7.15 (1 H, m), 3.85 (3 H, s), 3.72 (3 H, s), 2.22 (3 H, s).

[0761] Compound of the present invention 2-33: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1 H, s), 7.44-7.36 (2 H, m), 7.31-7.26 (2 H, m), 6.94-6.85 (2 H, m), 3.84 (3 H, s), 3.72 (3 H, s), 2.22 (3 H, s).

[0762] Compound of the present invention 2-34: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1 H, s), 7.41-7.30 (2 H, m), 7.26-7.24 (1 H, m), 7.18-7.12 (1 H, m), 7.03-6.96 (1 H, m), 3.85 (3 H, s), 3.72 (3 H, s), 2.23 (3 H, s).

[0763] Compound of the present invention 2-35: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1 H, s), 7.36-7.27 (2 H, m), 7.20 (1 H, s), 3.85 (3 H, s), 3.72 (3 H, s), 2.25 (3 H, s).

[0764] Compound of the present invention 2-36: .sup.1H—NMR (CDCl.sub.3) δ: 7.61 (1 H, s), 7.55-7.38 (5 H, m), 7.14-7.08 (2 H, m), 3.87 (3 H, s), 3.74 (3 H, s).

[0765] Compound of the present invention 2-37: .sup.1H—NMR (CDCl.sub.3) δ: 7.62 (1 H, s), 7.55 (1 H, t), 7.51-7.41 (4 H, m), 7.38-7.30 (2 H, m), 3.87 (3 H, s), 3.74 (3 H, s).

[0766] Compound of the present invention 2-38: .sup.1H—NMR (CDCl.sub.3) δ: 7.62 (1 H, s), 7.50-7.33 (5 H, m), 7.29-7.24 (1 H, m), 7.07-7.01 (1 H, m), 3.87 (3 H, s), 3.74 (3 H, s).

[0767] Compound of the present invention 2-39: .sup.1H—NMR (CDCl.sub.3) δ: 7.55 (1 H, s), 7.53-7.44 (3 H, m), 7.36 (1 H, d), 7.09 (2 H, t), 6.98 (1 H, d), 3.83 (3 H, s), 3.83 (3 H, s), 3.72 (3 H, s).

[0768] Compound of the present invention 2-40: .sup.1H—NMR (CDCl.sub.3) δ: 7.54 (1 H, s), 7.54-7.50 (1 H, m), 7.44 (1 H, td), 7.39 (1 H, t), 7.30-7.24 (1 H, m), 7.17 (1 H, td), 7.12 (1 H, m), 6.99 (1 H, d), 3.84 (3 H, s), 3.83 (3 H, s), 3.72 (3 H, s).

[0769] Compound of the present invention 2-43: .sup.1H—NMR (CDCl.sub.3) δ: 7.61 (1 H, s), 7.45 (1 H, dd), 7.34-7.28 (3 H, m), 7.18 (1 H, dt) , 7.12 (1 H, t), 6.86 (1 H, dd), 3.85 (3 H, s), 3.84 (3 H, s), 3.72 (3 H, s), 2.22 (3 H, s).

[0770] A compound represented by formula (2b):

##STR00087##

wherein a combination of R.sup.24, R.sup.25, R.sup.26, R.sup.27, and R.sup.28 represents any combinations described in [Table A13].

TABLE-US-00010 Compound of the present invention R.sup.24 R.sup.25 R.sup.26 R.sup.27 R.sup.28 2-41 H H F H H 2-42 F H H H H

[0771] Compound of the present invention 2-41: .sup.1H—NMR (CDCl.sub.3) δ: 7.59 (1 H, s), 7.56-7.50 (2 H, m), 7.28 (2 H, d), 7.14-7.07 (3 H, m), 3.87 (3 H, s), 3.75 (3 H, s), 2.42 (3 H, s).

[0772] Compound of the present invention 2-42: .sup.1H—NMR (CDCl.sub.3) δ: 7.58 (1 H, s), 7.44 (1 H, td), 7.33-7.27 (3 H, m), 7.21-7.10 (3 H, m), 3.86 (3 H, s), 3.75 (3 H, s), 2.42 (3 H, s).

Preparation Example 3

[0773] A mixture of 0.30 g of the intermediate compound 2, 2-bromopyridine 0.21 g, [1,1′-bis(diphenylphosphino)ferrocene]palladium (II) dichloride 0.07 g, tripotassium phosphate 0.27 g, dimethoxyethane 6 mL and water 0.1 mL was stirred at 80° C. under nitrogen atmosphere for 5 hours. The resulting mixture was cooled to room temperature, and then concentrated under reduced pressure. The residue was subjected to a silica gel column chromatography (ethyl acetate : hexane = 1:3) to obtain the compound of the present invention 4-1 represented by the following formula 0.15 g.

##STR00088##

[0774] Compound of the present invention 4-1: .sup.1H—NMR (CDCl.sub.3) δ: 8.66 (1 H, td), 7.85 (1 H, dd), 7.76 (1 H, d), 7.72-7.70 (2 H, m), 7.60 (1 H, s), 7.33 (1 H, d), 7.20-7.16 (1 H, m), 3.83 (3 H, s), 3.70 (3 H, s), 2.23 (3 H, s).

Preparation Example 3-1

[0775] The compounds which were prepared according to the Preparation Example 3 and their physical property value are shown below.

[0776] A compound represented by formula (1d):

##STR00089##

wherein a combination of R.sup.29, R.sup.30, R.sup.31, .sub.and R.sup.32 represents any combinations described in [Table A4].

TABLE-US-00011 Compound of the present invention R.sup.29 R.sup.30 R.sup.31 R.sup.32 4-2 Me H H H 4-3 F H H H 4-4 CF.sub.3 H H H 4-5 H F H H 4-6 H H H F 4-7 H CF.sub.3 H H 4-8 OMe H H H

[0777] Compound of the present invention 4-2: .sup.1H—NMR (CDCl.sub.3) δ: 7.84 (1 H, dd), 7.73 (1 H, d), 7.61-7.57 (2 H, m), 7.49 (1 H, d), 7.31 (1 H, d), 7.04 (1 H, d), 3.82 (3 H, s), 3.70 (3 H, s), 2.60 (3 H, s), 2.22 (3 H, s).

[0778] Compound of the present invention 4-3: .sup.1H—NMR (CDCl.sub.3) δ: 7.86 (1 H, dd), 7.83-7.77 (2 H, m), 7.61-7.59 (2 H, m), 7.32 (1 H, d), 6.81 (1 H, dd), 3.83 (3 H, s), 3.71 (3 H, s), 2.23 (3 H, s). Compound of the present invention 4-4: .sup.1H—NMR (CDCl.sub.3) δ: 7.94 (1 H, dd), 7.90-7.84 (2 H, m), 7.80 (1 H, d), 7.62 (1 H, s), 7.55 (1 H, dd), 7.35 (1 H, d), 3.84 (3 H, s), 3.71 (3 H, s), 2.24 (3 H, s).

[0779] Compound of the present invention 4-5: .sup.1H—NMR (CDCl.sub.3) δ: 8.51 (1 H, d), 7.80 (1 H,dd), 7.71-7.68 (2 H, m), 7.60 (1 H, s), 7.45-7.40 (1 H, m), 7.32 (1 H, d), 3.83 (3 H, s), 3.70 (3 H, s), 2.23 (3 H, s).

[0780] Compound of the present invention 4-6: .sup.1H—NMR (CDCl.sub.3) δ: 8.48 (1 H, td), 7.86 (1 H, dt), 7.77 (1 H, t), 7.60 (1 H, s), 7.43 (1 H, ddd), 7.33 (1 H, d), 7.22-7.18 (1 H, m), 3.81 (3 H, s), 3.69 (3 H, s), 2.24 (3 H, s).

[0781] Compound of the present invention 4-7: .sup.1H—NMR (CDCl.sub.3) δ: 8.91 (1 H, dd), 7.94-7.89 (2 H, m), 7.83-7.80 (2 H, m), 7.62 (1 H, s), 7.36 (1 H, d), 3.83 (3 H, s), 3.71 (3 H, s), 2.25 (3 H, s). Compound of the present invention 4-8: .sup.1H-NMR (CDCl.sub.3) δ: 7.92 (1 H, dd), 7.76 (1 H, d), 7.61-7.57 (2 H, m), 7.31 (2 H, dd), 6.64 (1 H, dd), 4.02 (3 H, s), 3.83 (3 H, s), 3.71 (3 H, s), 2.23 (3 H, s).

[0782] The compound represented by formula (1c) wherein E represents a substituent described in [Table A5] . [0137]

TABLE-US-00012 Compound present of invention the E 5-1 [00090] 5-2 [00091] 5-3 [00092] 5-4 [00093] 5-5 [00094] 5-6 [00095] 5-7 [00096] 5-8 [00097] 5-9 [00098] 5-10 [00099] 5-11 [00100] 5-12 [00101] 5-13 [00102] 5-14 [00103] 5-15 [00104]

TABLE-US-00013 5-16 [00105] 5-17 [00106] 5-18 [00107] 5-19 [00108] 5-20 [00109]

[0783] Compound of the present invention 5-1: .sup.1H—NMR (CDCl.sub.3) δ: 8.77 (2 H, d), 8.31 (1 H, d), 8.20 (1 H, s), 7.61 (1 H, s), 7.35 (1 H, d), 7.15-7.11 (1 H, m), 3.82 (3 H, s), 3.70 (3 H, s), 2.25 (3 H, s) .

[0784] Compound of the present invention 5-2: .sup.1H—NMR (CDCl.sub.3) δ: 8.61 (1 H, d), 8.31 (1 H, dd), 8.19 (1 H, d), 7.60 (1 H, s), 7.33 (1 H, d), 7.00 (1 H, d), 3.82 (3 H, s), 3.69 (3 H, s), 2.56 (3 H, s), 2.24 (3 H, s).

[0785] Compound of the present invention 5-3: .sup.1H—NMR (CDCl.sub.3) δ: 8.99 (1 H, d), 8.37 (1 H, dd), 8.25 (1 H, d), 7.63 (1 H, d), 7.45 (1 H, d), 7.37 (1 H, t), 3.84 (3 H, s), 3.71 (3 H, s), 2.26 (3 H, s).

[0786] Compound of the present invention 5-4: .sup.1H—NMR (CDCl.sub.3) δ: 9.01 (1 H, d), 8.60 (1 H, dd), 8.46 (1 H, d), 7.89 (1 H, dd), 7.79 (1 H, d), 7.62 (1 H, s), 7.37 (1 H, d), 3.85 (3 H, s), 3.72 (3 H, s), 2.25 (3 H, s).

[0787] Compound of the present invention 5-5: .sup.1H—NMR (CDCl.sub.3) δ: 8.79 (1 H, d), 7.91 (1 H, dd), 7.81 (1 H, d), 7.61 (1 H, s), 7.34 (1 H, d), 7.11 (1 H, d), 4.07 (2 H, s), 3.84 (3 H, s), 3.71 (3 H, s), 2.24 (3 H, s), 1.05 (9 H, s).

[0788] Compound of the present invention 5-6: .sup.1H—NMR (CDCl.sub.3) δ: 8.80 (1 H, d), 7.95 (1 H,dd), 7.85 (1 H, d), 7.63-7.31 (7 H, m), 3.85 (3 H, s), 3.72 (3 H, s), 2.27 (3 H, s).

[0789] Compound of the present invention 5-7: .sup.1H—NMR (CDCl.sub.3) δ: 8.79 (1 H,s), 7.94 (1 H, dd), 7.89-7.85 (2 H, m), 7.62 (1 H,s), 7.52-7.45 (2 H, m), 7.41-7.34 (3 H, m), 3.85 (3 H, s), 3.71 (3 H, s), 2.26 (3 H, s).

[0790] Compound of the present invention 5-8: .sup.1H—NMR (CDCl.sub.3) δ: 7.84 (1 H, d), 7.75 (1 H, s), 7.63 (1 H, s), 7.38 (1 H, d), 3.86 (3 H, s), 3.72 (3 H, s), 2.27 (3 H, s).

[0791] Compound of the present invention 5-9: .sup.1H-NMR (CDCl.sub.3) δ: 7.78 (1 H, dd), 7.70 (1 H, d), 7.61 (1 H, s), 7.34 (1 H, d), 3.85 (3 H, s), 3.71 (3 H, s), 2.71 (3 H, s), 2.24 (3 H, s).

[0792] Compound of the present invention 5-10: .sup.1H—NMR (CDCl.sub.3) δ: 7.80 (1 H, dd), 7.69 (1 H, d), 7.62 (1 H, s), 7.32 (1 H, d), 3.85 (3 H, s), 3.72 (3 H, s), 2.24 (3 H, s), 1.48 (9 H, s). Compound of the present invention 5-11: .sup.1H—NMR (CDCl.sub.3) δ: 8.39-8.37 (2 H, m), 7.89 (1 H, dd) , 7.80 (1 H, d), 7.64 (1 H, s), 7.52-7.47 (3 H, m), 7.37 (1 H, d), 3.86 (3 H, s), 3.73 (3 H, s), 2.26 (3 H, s).

[0793] Compound of the present invention 5-12: .sup.1H—NMR (CDCl.sub.3) δ: 7.93-7.86 (3 H, m), 7.79 (1 H, d), 7.65 (1 H, s), 7.38 (1 H, d), 6.92 (1 H, tt) , 3.87 (3 H, s), 3.74 (3 H, s), 2.27 (3 H, s).

[0794] Compound of the present invention 5-13: .sup.1H—NMR (CDCl.sub.3) δ: 7.67 (1 H, dd), 7.58 (1 H, s), 7.54 (1 H, d), 7.49 (1 H, d), 7.22 (1 H, d), 6.46 (1 H, d), 3.81 (3 H, s), 3.69 (3 H, s), 2.18 (3 H, s), 1.61 (9 H, s).

[0795] Compound of the present invention 5-14: .sup.1H—NMR (CDCl.sub.3) δ: 7.64 (1 H, dd), 7.57 (1 H, s), 7.54 (1 H, d), 7.36 (1 H, d), 7.25-7.22 (1 H, m), 6.49 (1 H, d), 4.10 (2 H, t), 3.81 (3 H, s), 3.69 (3 H, s), 2.19 (3 H, s), 1.96-1.87 (2 H, m), 0.93 (3 H, t). Compound of the present invention 5-15: .sup.1H—NMR (CDCl.sub.3) δ: 7.59 (1 H, s), 7.53 (1 H, d), 7.32-7.27 (1 H, m), 7.24 (1 H, dd), 7.15 (1 H, d), 6.27 (1 H, d), 4.00 (2 H, d), 3.85 (3 H, s), 3.72 (3 H, s), 2.23 (3 H, s), 1.24-1.18 (1 H, m), 0.50-0.45 (2 H, m), 0.22-0.18 (2 H, m).

[0796] Compound of the present invention 5-16: .sup.1H—NMR (CDCl.sub.3) δ: 8.84 (1 H, dd), 8.55 (1 H, dd), 7.88-7.85 (1 H, m), 7.62 (1 H, s), 7.45 (1 H, dd), 7.35-7.31 (3 H, m), 3.85 (3 H, s), 3.73 (3 H, s), 2.24 (3 H, s).

[0797] Compound of the present invention 5-17: .sup.1H—NMR (CDCl.sub.3) δ: 9.12 (1 H, dd), 7.96 (1 H, dd), 7.87-7.83 (2 H, m), 7.62 (1 H, s), 7.49 (1 H, dd), 7.39 (1 H, d), 3.84 (3 H, s), 3.71 (3 H, s), 2.26 (3 H, s).

[0798] Compound of the present invention 5-18: .sup.1H—NMR (CDCl.sub.3) δ: 7.60 (1 H, s), 7.52 (1 H, d), 7.30 (1 H, d), 7.23 (1 H, dd), 7.14 (1 H, d), 6.25 (1 H, d), 4.10-4.06 (2 H, m), 3.85 (3 H, s), 3.72 (3 H, s), 2.24 (3 H, s), 1.89-1.80 (2 H, m), 0.84 (3 H, t).

[0799] Compound of the present invention 5-19: .sup.1H—NMR (CDCl.sub.3) (5: 7.64 (1 H, dd), 7.58 (1 H, s), 7.55-7.54 (1 H, m), 7.50 (1 H, d), 7.24 (1 H, d), 6.51 (1 H, d), 4.02 (2 H, d), 3.81 (3 H, s), 3.69 (3 H, s), 2.19 (3 H, s), 1.35-1.30 (1 H, m), 0.67-0.62 (2 H, m), 0.40-0.36 (2 H, m) .

[0800] Compound of the present invention 5-20: .sup.1H—NMR (CDCl.sub.3) δ: 7.89 (1 H, dd), 7.77 (1 H, d), 7.61 (1 H, s), 7.35 (1 H, d), 3.85 (3 H, s), 3.71 (3 H, s), 2.24 (3 H, s), 1.47 (9 H, s).

Preparation Example 4

[0801] A mixture of 0.30 g of the intermediate compound 1, pyrazole 0.1 mL, copper (I) iodide 0.20 g, potassium carbonate 0.29 g, trans-N,N-dimethylcyclohexane-1,2-diamine 0.17 mL and DMF 10 mL was stirred at 120° C. under nitrogen atmosphere for 5 hours. The resulting mixture was cooled to room temperature, and then concentrated under reduced pressure. The resulting residue was subjected to a silica gel column chromatography (hexane : ethyl acetate = 1:4) to obtain the compound of the present invention 6-1 represented by the following formula 0.20 g.

##STR00110##

[0802] Compound of the present invention 6-1: .sup.1H—NMR (CDCl.sub.3) δ: 7.89 (1 H, d), 7.69 (1 H, d), 7.60 (1 H, s), 7.53 (1 H, dd), 7.45 (1 H, d), 7.29 (1 H, d), 6.43 (1 H, t), 3.84 (3 H, s), 3.71 (3 H, s), 2.20 (3 H, s).

Preparation Example 4-1

[0803] The compounds which were prepared according to the Preparation Example 4 and their physical property value are shown below.

[0804] A compound represented by formula (If):

##STR00111##

wherein R.sup.33 represents a substituent described in [Table A6] .

TABLE-US-00014 Compound of the present invention R.sup.33 6-2 c-Pr 6-3 t-Bu 6-4 Me 6-5 CF.sub.3 6-6 [00112] 6-7 [00113] 6-8 [00114]

[0805] Compound of the present invention 6-2: .sup.1H—NMR (CDCl.sub.3) δ: 7.74 (1 H, d), 7.58 (1 H, s), 7.48 (1 H, dd), 7.40 (1 H, d), 7.24 (1 H, s), 6.05 (1 H, d) , 3.83 (3 H, s), 3.70 (3 H, s), 2.18 (3 H, s) , 2.05-2.00 (1 H, m), 0.98-0.93 (2 H, m), 0.80-0.76 (2 H, m).

[0806] Compound of the present invention 6-3: .sup.1H—NMR (CDCl.sub.3) δ: 7.74 (1 H, d), 7.59 (1 H, s), 7.51 (1 H, dd), 7.39 (1 H, d), 7.26-7.24 (1 H, m), 6.27 (1 H, d), 3.83 (3 H,s), 3.70 (3 H, s), 2.18 (3 H, s), 1.36 (9 H, s).

[0807] Compound of the present invention 6-4: .sup.1H—NMR (CDCl.sub.3) δ: 7.77 (1 H, d), 7.58 (1 H, s), 7.48 (1 H, dd), 7.41 (1 H, d), 7.27-7.25 (1 H, m), 6.21 (1 H, d), 3.83 (3 H, s), 3.70 (3 H, s), 2.37 (3 H, s), 2.19 (3 H, s).

[0808] Compound of the present invention 6-5: .sup.1H—NMR (CDCl.sub.3) δ: 7.90 (1 H, d), 7.60 (y s), 7.54 (1 H, dd), 7.45 (1 H, d), 7.32 (1 H, d), 6.68 (1 H, d), 3.85 (3 H, s), 3.71 (3 H, s), 2.22 (3 H, s) . Compound of the present invention 6-6: .sup.1H—NMR (CDCl.sub.3) δ: 7.92-7.89 (3 H, m), 7.62-7.60 (2 H, m), 7.52 (1 H, d), 7.44-7.37 (2 H, m), 7.34-7.29 (2 H, m), 6.74 (1 H, d), 3.85 (3 H, s), 3.72 (3 H, s), 2.21 (3 H, s).

[0809] Compound of the present invention 6-7: .sup.1H—NMR (CDCl.sub.3) δ: 7.91 (1 H, d), 7.84 (2 H, dt) , 7.61 (1 H, s), 7.59 (1 H, dd), 7.51 (1 H, d), 7.38 (2 H, dt), 7.31 (1 H, d), 6.71 (1 H, d), 3.85 (3 H, s), 3.72 (3 H, s), 2.21 (3 H, s).

[0810] Compound of the present invention 6-8: .sup.1H—NMR (CDCl.sub.3) δ: 7.94 (1 H, d), 7.90-7.84 (1 H, m), 7.61 (1 H, s), 7.59 (1 H, dd), 7.50 (1 H, d), 7.31 (1 H, d), 7.06-6.99 (1 H, m), 6.85 (1 H, dd), 3.85 (3 H, s), 3.72 (3 H, s), 2.22 (3 H, s).

Preparation Example 5

[0811] To a mixture of 1-(4-chlorophenyl)-1H-pyrazole-3-ol 0.95 g and chloroform 10 mL were added trifluoroacetic anhydride 0.88 mL and triethylamine 0.74 mL at 0° C. successively, and the mixture was stirred at room temperature for 1 hour. Water was added to the resulting mixture, and the mixture was extracted with ethyl acetate. The resulting organic layers were washed with water and saturated brine successively, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. To the resulting residue were added 0.8 g of the intermediate compound 2, [1,1′-bis(diphenylphoshino)ferrocene]palladium (II) dichloride 0.18 g, tripotassium phosphate 1.53 g, and dimethoxyethane 10 mL under nitrogen atmosphere successively, and the mixture was stirred at 80° C. for 9 hours. To the resulting mixture was added ethyl acetate, and the mixture was washed with water and saturated brine successively. The resulting organic layers were dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residue was subjected to a silica gel column chromatography (ethyl acetate : hexane = 1:4) to obtain the compound of the present invention 7-1 represented by the following formula 0.12 g.

##STR00115##

[0812] Compound of the present invention 7-1: .sup.1H—NMR (CDCl.sub.3) δ: 7.82 (1 H, d), 7.71 (1 H, dd), 7.66-7.64 (3 H, m), 7.59 (1 H, s), 7.38-7.35 (2 H, m), 7.27 (1 H, d), 6.69 (1 H, d), 3.78 (3 H, s), 3.69 (3 H, s), 2.21 (3 H, s).

Preparation Example 6

[0813] To a mixture of 0.25 g of the intermediate compound 3, O-benzylhydroxyamine hydrochloride salt 0.16 g, and methanol 3 mL was added pyridine 0.16 mL at 0° C., and the mixture was stirred at room temperature for 4 hours. The resulting mixture was diluted with ethyl acetate, and washed with water and saturated brine successively. The resulting organic layers were dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residue was subjected to a silica gel column chromatography (ethyl acetate : hexane = 1:4) to obtain the compound of the present invention 8-1 represented by the following formula 0.35 g.

##STR00116##

[0814] Compound of the present invention 8-1: .sup.1H—NMR (CDCl.sub.3) δ: 7.57 (1 H, s), 7.52 (1 H, dd), 7.38 (6 H, m), 7.20 (1 H, d), 5.22 (2 H, s), 3.82 (3 H, s), 3.69 (3 H, s), 2.24 (3 H, s), 2.18 (3 H, s).

Preparation Example 6-1

[0815] The compounds which were prepared according to the Preparation Example 6 and their physical property value are shown below.

[0816] A compound represented by formula (1h):

##STR00117##

wherein a combination of R.sup.4 and R.sup.5 represents any combinations described in [Table A7].

TABLE-US-00015 Compound of the present invention R.sup.4 R.sup.5 8-2 Me CH.sub.2-c-Pr 8-3 Me CH.sub.2-C = CH 8-4 H CH.sub.2—Ph 8-5 H CH.sub.2-c-Pr 8-6 Me i-Pr 8-7 H i-Pr 8-8 H Me 8-9 H Et 8-10 H Pr 8-11 H Pen 8-12 H i-Bu 8-13 H CH.sub.2CF.sub.2CF.sub.3 8-14 H CH.sub.2CF.sub.3 8-15 Me Me 8-16 Me Et 8-17 Me Pen 8-18 Me Ph 8-19 Et Me 8-20 Et Et 8-21 Me c-Hex

[0817] Compound of the present invention 8-2: .sup.1H—NMR (CDCl.sub.3) δ: 7.57 (1 H, s), 7.51 (1 H, dd), 7.39 (1 H, d), 7.21 (1 H, d), 3.99 (2 H, d), 3.82 (3 H, d), 3.70 (3 H, d), 2.23 (3 H, s), 2.18 (3 H, s), 1.24-1.17 (1 H, m), 0.57-0.53 (2 H, m), 0.32-0.30 (2 H, m).

[0818] Compound of the present invention 8-3: .sup.1H—NMR (CDCl.sub.3) δ: 7.58 (1 H, s), 7.53 (1 H, dd), 7.39 (1 H, d), 7.22 (1 H, d), 4.78 (2 H, d), 3.82 (3 H, s), 3.70 (3 H, s), 2.47 (1 H, t), 2.23 (3 H, s), 2.18 (3 H, s).

[0819] Compound of the present invention 8-4: .sup.1H—NMR (CDCl.sub.3) δ: 8.10 (1 H, s), 7.57 (1 H, s), 7.47-7.29 (7 H, m), 7.22 (1 H, d), 5.19 (2 H, s), 3.82 (3 H, s), 3.69 (3 H, s), 2.18 (3 H, s).

[0820] Compound of the present invention 8-5: .sup.1H—NMR (CDCl.sub.3) δ: 8.07 (1 H, s), 7.57 (1 H, s), 7.45 (1 H, dd), 7.30 (1 H, d), 7.22 (1 H, d), 3.97 (2 H, d), 3.83 (3 H, s), 3.70 (3 H, s), 2.18 (3 H, s), 1.23-1.16 (1 H, m), 0.60-0.54 (2 H, m), 0.34-0.29 (2 H, m).

[0821] Compound of the present invention 8-6: .sup.1H—NMR (CDCl.sub.3) δ: 7.57 (1 H, s), 7.53 (1 H, dd), 7.38 (1 H, d), 7.20 (1 H, d), 4.46-4.40 (1 H, m), 3.82 (3 H, s), 3.70 (3 H, s), 2.19 (3 H, s), 2.18 (3 H, s), 1.29 (6 H, d).

[0822] Compound of the present invention 8-7: .sup.1H—NMR (CDCl.sub.3) δ: 8.01 (1 H, s), 7.57 (1 H, s), 7.45 (1 H, dd), 7.30 (1 H, d), 7.22 (1 H, d), 4.46-4.40 (1 H, m), 3.83 (3 H, s), 3.70 (3 H, s), 2.18 (3 H, s), 1.28 (6 H, d).

[0823] Compound of the present invention 8-8: .sup.1H—NMR (CDCl.sub.3 δ:8.02 (1 H, s), 7.57 (1 H, s), 7.44 (1 H, dd), 7.31 (1 H, d), 7.23 (1 H, d), 3.95 (3 H, s), 3.83 (3 H, s), 3.70 (3 H, s), 2.19 (3 H, s). Compound of the present invention 8-9: .sup.1H—NMR (CDCl.sub.3) δ: 8.03 (1 H, s), 7.57 (1 H, s), 7.45 (1 H, d), 7.31 (1 H, s), 7.22 (1 H, d), 4.20 (2 H, q), 3.83 (3 H, s), 3.70 (3 H, s), 2.19 (3 H, s), 1.31 (3 H, t).

[0824] Compound of the present invention 8-10: .sup.1H—NMR (CDCl.sub.3) δ: 8.04 (1 H, s), 7.57 (1 H, s), 7.45 (1 H, dd), 7.31 (1 H, d), 7.22 (1 H, d), 4.10 (2 H, t), 3.83 (3 H, s), 3.70 (3 H, s), 2.18 (3 H, s), 1.72 (2 H, td), 0.97 (3 H, t).

[0825] Compound of the present invention 8-11: .sup.1H—NMR (CDCl.sub.3) δ: 8.03 (1 H, s), 7.57 (1 H, s), 7.45 (1 H, dd), 7.30 (1 H, d), 7.22 (1 H, d), 4.14 (2 H, t), 3.83 (3 H, s), 3.70 (3 H, s), 2.18 (3 H, s), 1.76-1.64 (2 H, m), 1.43-1.31 (4 H, m), 0.96-0.86 (3 H, m) .

[0826] Compound of the present invention 8-12: .sup.1H—NMR (CDCl.sub.3)δ: 8.05 (1 H, s), 7.57 (1 H, s), 7.45 (1 H, dd), 7.30 (1 H, d), 7.22 (1 H, d), 3.91 (2 H, d), 3.83 (3 H, s), 3.70 (3 H, s), 2.18 (3 H, s), 2.09-1.98 (1 H, m), 0.95 (6 H, d).

[0827] Compound of the present invention 8-13: .sup.1H—NMR (CDCl.sub.3) δ: 8.10 (1 H, s), 7.58 (1 H, s), 7.46 (1 H, dd), 7.30 (1 H, d), 7.25 (1 H, d), 4.64-4.55 (2 H, m), 3.84 (3 H, s), 3.71 (3 H, s), 2.20 (3 H, s).

[0828] Compound of the present invention 8-14: .sup.1H—NMR (CDCl.sub.3) δ: 8.12 (1 H, s), 7.58 (1 H, s), 7.46 (1 H, dd), 7.30 (1 H, d), 7.24 (1 H, d), 4.50 (2 H, q), 3.84 (3 H, s), 3.70 (3 H, s), 2.20 (3 H, s).

[0829] Compound of the present invention 8-15: .sup.1H—NMR (CDCl.sub.3) δ: 7.57 (1 H, s), 7.50 (1 H, dd), 7.39 (1 H, d), 7.21 (1 H, d), 3.97 (3 H, s), 3.82 (3 H, s), 3.69 (3 H, s), 2.19 (3 H, s), 2.18 (3 H, s).

[0830] Compound of the present invention 8-16: .sup.1H—NMR (CDCl.sub.3) δ: 7.57 (1 H, s), 7.51 (1 H, dd), 7.39 (1 H, d), 7.21 (1 H, d), 4.22 (2 H, q), 3.82 (3 H, s), 3.70 (3 H, s), 2.20 (3 H, s), 2.18 (3 H, s), 1.31 (3 H, t) .

[0831] Compound of the present invention 8-17: .sup.1H—NMR (CDCl.sub.3) δ: 7.57 (1 H, s), 7.51 (1 H, dd), 7.38 (1 H, d), 7.21 (1 H, d), 4.16 (2 H, t), 3.82 (3 H, s), 3.69 (3 H, s), 2.20 (3 H, s), 2.18 (3 H, s), 1.76-1.65 (2 H, m), 1.41-1.32 (4 H, m), 0.94-0.88 (3 H, m) .

[0832] Compound of the present invention 8-18: .sup.1H—NMR (CDCl.sub.3) δ: 7.65 (1 H, dd), 7.60 (1 H, s), 7.52 (1 H, d), 7.35-7.25 (5 H, m), 7.04-6.99 (1 H, m), 3.84 (3 H, s), 3.71 (3 H, s), 2.42 (3 H, s), 2.21 (3 H, s).

[0833] Compound of the present invention 8-19: .sup.1H—NMR (CDCl.sub.3) δ: 7.57 (1 H, s), 7.50 (1 H, dd), 7.38 (1 H, d), 7.21 (1 H, d), 3.95 (3 H, s), 3.81 (3 H, s), 3.69 (3 H, s), 2.71 (2 H, q), 2.18 (3 H, s), 1.13 (3 H, t).

[0834] Compound of the present invention 8-20: .sup.1H—NMR (CDCl.sub.3) δ: 7.57 (1 H, s), 7.51 (1 H, dd), 7.38 (1 H, d), 7.21 (1 H, d), 4.21 (2 H, q), 3.82 (3 H, s), 3.70 (3 H, s), 2.72 (2 H, q), 2.18 (3 H, s), 1.30 (3 H, t), 1.13 (3 H, t).

[0835] Compound of the present invention 8-21: .sup.1H—NMR (CDCl.sub.3) δ: 7.57 (1 H, s), 7.52 (1 H, dd), 7.38 (1 H, d), 7.20 (1 H, d), 4.21-4.14 (1 H, m), 3.82 (3 H, s), 3.69 (3 H, s), 2.20 (3 H, s), 2.18 (3 H, s), 2.03-1.93 (2 H, m), 1.79-1.69 (2 H, m), 1.58-1.28 (6 H, m).

Preparation Example 7

[0836] A mixture of sodium hydride (60% in oil) 0.04 g and DMF 3 mL was stirred at 0° C. for 30 minutes. To the resulting mixture was added 0.25 g of the intermediate compound 4 under ice-cooling, and the mixture was stirred at room temperature for 4 hours. To the resulting mixture was added (bromomethyl)cyclobutene 0.16 mL at 0° C., and the mixture was stirred at room temperature for 2 hours. To the resulting mixture was added aqueous saturated ammonium chloride solution, and the mixture was extracted with ethyl acetate. The resulting organic layers were washed with water and saturated brine successively, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residue was subjected to a silica gel column chromatography (ethyl acetate : hexane = 1:4) to obtain the compound of the present invention 9-1 represented by the following formula 0.20 g.

##STR00118##

[0837] Compound of the present invention 9-1: .sup.1H—NMR (CDCl.sub.3) δ: 7.57 (1 H,s), 7.51 (1 H, d), 7.38 (1 H, s), 7.20 (1 H, d), 4.15 (2 H, d), 3.82 (3 H, s), 3.70 (3 H, s), 2.75-2.67 (1 H, m), 2.20 (3 H, s), 2.18 (3 H, s), 2.10-2.04 (2 H, m), 1.96-1.79 (4 H, m).

Preparation Example 7-1

[0838] The compounds which were prepared according to the Preparation Example 7 and their physical property value are shown below.

[0839] The compounds represented by formula (1h) wherein a combination of R.sup.4 and R.sup.5 represents any combinations described in [Table A8].

TABLE-US-00016 Compound of the present invention R.sup.4 R.sup.5 9-2 Me [00119] 9-3 Me [00120] 9-4 Me [00121] 9-5 Me [00122] 9-6 Me [00123]

[0840] Compound of the present invention 9-2: .sup.1H—NMR (CDCl.sub.3) δ: 7.57 (1 H, s), 7.52 (1 H, dd), 7.39-7.37 (2 H, m), 7.24-7.17 (4 H, m), 5.23 (2 H, s), 3.82 (3 H, s), 3.69 (3 H, s), 2.39 (3 H, s), 2.23 (3 H, s), 2.18 (3 H, s).

[0841] Compound of the present invention 9-3: .sup.1H—NMR (CDCl.sub.3) δ: 7.57 (1 H, s), 7.52 (1 H, dd), 7.39 (1 H, d), 7.23-7.21 (4 H, m), 7.11 (1 H, d), 5.19 (2 H, s), 3.82 (3 H, s), 3.69 (3 H, s), 2.36 (3 H, s), 2.23 (3 H, s), 2.18 (3 H, s).

[0842] Compound of the present invention 9-4: .sup.1H—NMR (CDCl.sub.3) δ: 7.57 (1 H, s), 7.52 (1 H, dd), 7.38 (1 H, d), 7.31 (2 H, d), 7.20 (1 H, d), 7.16 (2 H, d), 5.17 (2 H, s), 3.82 (3 H, s), 3.69 (3 H, s), 2.35 (3 H, s), 2.22 (3 H, s), 2.18 (3 H, s).

[0843] Compound of the present invention 9-5: .sup.1H—NMR (CDCl.sub.3) δ: 7.57 (1 H, s), 7.52 (1 H, dd), 7.47-7.43 (1 H, m), 7.38 (1 H, d), 7.30-7.25 (1 H, m), 7.20 (1 H, d), 7.14-7.10 (1 H, m), 7.07-7.03 (1 H, m), 5.29 (2 H, s), 3.82 (3 H, s), 3.69 (3 H, s), 2.23 (3 H, s), 2.18 (3 H, s).

[0844] Compound of the present invention 9-6: .sup.1H—NMR (CDCl.sub.3) δ:7.58-7.50 (3 H, m), 7.39 (1 H, d), 7.20 (2 H, dd), 7.04 (1 H, d), 5.32 (2 H, s), 3.81 (3 H, s), 3.69 (3 H, s), 2.56 (3 H, s), 2.30 (3 H, s), 2.17 (3 H, s).

Preparation Example 8

[0845] A mixture of 0.45 g of the intermediate compound 8, butanol 0.23 g, bis(2-methoxyethyl) azocarboxylate 0.62 g, triphenylphosphine 0.64 g, and chloroform 5 mL was stirred at room temperature for 1 hour. The resulting mixture was concentrated under reduced pressure. The resulting residue was subjected to a silica gel column chromatography (ethyl acetate : hexane = 1:4) to obtain a compound of the present invention 10-1 represented by the following formula 0.21 g.

##STR00124##

[0846] Compound of the present invention 10-1: .sup.1H—NMR (CDCl.sub.3) δ: 7.54 (1 H, s), 7.11 (1 H, d), 6.77 (1 H, dd), 6.67 (1 H, d), 3.92 (2 H, t), 3.82 (3 H, s), 3.70 (3 H, s), 2.10 (3 H, s), 1.77-1.70 (2 H, m), 1.52-1.43 (2 H, m), 0.96 (3 H, t).

Preparation Example 8-1

[0847] The compounds which were prepared according to the Preparation Example 8 and their physical property value are shown below.

[0848] The compound of the present invention 10-2 to the compound of the present invention 10-8, which corresponds to a compound represented by formula (1k):

##STR00125##

wherein R.sup.6 represents a substituent described below.

[0849] Compound of the present invention 10-2 (R.sup.6— Pr) : .sup.1H—NMR (CDCl.sub.3) δ: 7.54 (1 H, s), 7.11 (1 H, d), 6.77 (1 H, dd), 6.67 (1 H, d), 3.88 (2 H, t), 3.82 (3 H, s), 3.70 (3 H, s), 2.10 (3 H, s), 1.83-1.74 (2 H, m), 1.02 (3 H, t).

[0850] Compound of the present invention 10-3 (R.sup.6— CH.sub.2CHMe.sub.2)— .sup.1H—NMR (CDCl.sub.3) δ: 7.54 (1 H, s), 7.11 (1 H, d), 6.77 (1 H, dd), 6.66 (1 H, d), 3.82 (3 H, s), 3.70 (3 H, s), 3.68 (2 H, d), 2.10 (3 H, s), 2.09-2.00 (1 H, m), 1.00 (6 H, d).

[0851] Compound of the present invention 10-4 (R.sup.6— CH.sub.2CH.sub.3)— .sup.1H—NMR (CDCl.sub.3) δ: 7.54 (1 H, s), 7.11 (1 H, d), 6.77 (1 H, dd), 6.67 (1 H, d), 4.00 (2 H, q), 3.82 (3 H, s), 3.70 (3 H, s), 2.10 (3 H, s), 1.38 (3 H, t).

[0852] Compound of the present invention 10-5 (R.sup.6— CH.sub.2(c—Pr)): .sup.1H—NMR (CDCl.sub.3) δ: 7.54 (1 H, s), 7.11 (1 H, d), 6.78 (1 H, dd), 6.67 (1 H, d), 3.82 (3 H, s), 3.76 (2 H, d), 3.70 (3 H, s), 2.10 (3 H, s), 1.29-1.23 (1 H, m), 0.6-0.60 (2 H, m), 0.34-0.30 (2 H, m) .

[0853] Compound of the present invention 10-6 (R.sup.6— CH.sub.2CH.sub.2OMe)— .sup.1H—NMR (CDCl.sub.3) δ: 7.54 (1 H, s), 7.11 (1 H, d), 6.80 (1 H, dd), 6.70 (1 H, d), 4.10-4.08 (2 H, m), 3.82 (3 H, s), 3.74-3.70 (2 H, m), 3.69 (3 H, s), 3.44 (3 H, s), 2.10 (3 H, s).

[0854] Compound of the present invention 10-7 (R.sup.6— Pen): .sup.1H—NMR (CDCl.sub.3) δ: 7.54 (1 H, s), 7.10 (1 H, d), 6.76 (1 H, dd), 6.66 (1 H, d), 3.91 (2 H, t), 3.82 (3 H, s), 3.69 (3 H, s), 2.09 (3 H, s), 1.80-1.71 (2 H, m), 1.46-1.31 (4 H, m), 0.91 (3 H, t).

[0855] Compound of the present invention 10-8 (R.sup.6— CH.sub.2CH.sub.2F)— .sup.1H—NMR (CDCl.sub.3) δ: 7.55 (1 H, s), 7.13 (1 H, d), 6.80 (1 H, dd), 6.70 (1 H, d), 4.73 (2 H, dt), 4.18 (2 H, dt), 3.82 (3 H, s), 3.69 (3 H, s), 2.10 (3 H, s).

Preparation Example 9

[0856] A mixture of 0.30 g of the intermediate compound 1, cyclohexene 0.43 g, acetylacetone palladium (II) 0.13 g, diisopropylamine 0.16 g, tetrafluoroboronic acid tri-tert-butyl phosphine 0.06 g, and N,N′-dimethylpropylene urea 3 mL was stirred at 130° C. for 5 hours. The resulting mixture was cooled to room temperature, and then concentrated under reduced pressure. The resulting residue was subjected to a silica gel column chromatography (ethyl acetate , hexane = 1:2) to obtain the compound 3-8 of the present invention represented by the following formula 0.20 g.

##STR00126##

[0857] Compound of the present invention 3-8: LCMS: 287 [M+H].sup.+, RT = 2.27 minutes

Preparation Example 9-1

[0858] The compounds which were prepared according to the Preparation Example 9 and their physical property value are shown below.

##STR00127##

[0859] Compound of the present invention 3-9: .sup.1H—NMR (CDCl.sub.3) δ: 7.57 (1 H, s), 7.29 (1 H, dd), 7.18-7.15 (2 H, m), 6.12-6.10 (1 H, m), 3.81 (3 H, s), 3.69 (3 H, s), 2.70-2.65 (2 H, m), 2.53-2.47 (2 H, m), 2.16 (3 H, s), 2.02-1.97 (2 H, m) .

Preparation Example 10

[0860] To a mixture of 0.25 g of the intermediate compound 8, potassium carbonate 0.23 g, and acetonitrile 5 mL was added dimethyl carbamoyl chloride 0.17 mL at 0° C. under nitrogen atmosphere, and the mixture was stirred at room temperature for 7 hours. To the resulting mixture was added aqueous saturated sodium hydrogencarbonate solution, and the mixture was extracted with ethyl acetate. The resulting organic layers were washed with water and saturated brine successively, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residue was subjected to a silica gel column chromatography (ethyl acetate : hexane = 1:3) to obtain a compound of the present invention 11-1 represented by the following formula 0.27 g.

##STR00128##

[0861] Compound of the present invention 11-1: .sup.1H—NMR (CDCl.sub.3) δ: 7.55 (1 H, s), 7.18 (1 H, d), 6.99 (1 H, dd), 6.87 (1 H, d), 3.81 (3 H, s), 3.69 (3 H, s), 3.07 (3 H, s), 3.00 (3 H, s), 2.14 (3 H, s).

Preparation Example 10-1

[0862] The compounds which were prepared according to the Preparation Example 10 and their physical property value are shown below.

##STR00129##

[0863] Compound of the present invention 11-2: .sup.1H—NMR (CDCl.sub.3) δ: 7.55 (1 H, s), 7.18 (1 H, d), 7.00 (1 H, dd), 6.88 (1 H, d), 3.81 (3 H, s), 3.69 (3 H, s), 3.46-3.32 (4 H, m), 2.14 (3 H, s), 1.26-1.15 (6 H, m). [0155]

##STR00130##

[0864] Compound of the present invention 11-3: .sup.1H—NMR (CDCl.sub.3) δ: 7.53 (1 H, s), 7.41-7.31 (4 H, m), 7.28-7.21 (1 H, m), 7.17 (1 H, d), 7.02-6.97 (1 H, m), 6.85 (1 H, s), 3.80 (3 H, s), 3.67 (3 H, s), 3.41 (3 H, s), 2.13 (3 H, s).

[0865] Next, examples of the compounds of the present invention and the intermediate compounds which are prepared according to the Preparation Examples described in Working Examples and the Processes described herein are shown below.

[0866] A compound represented by formula (1A):

##STR00131##

wherein Q represents Q1, R.sup.1 represents a methyl group, and R.sup.7 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX1).

[0867] Group X: a group consisting of Me,Et,Pr,i-Pr,c-Pr,c—Bu,c— Pen,c—Hex, (CH.sub.2).sub.3CH.sub.3,CH.sub.2 CH(CH.sub.3).sub.2,CH(CH.sub.3)CH.sub.2 CH.sub.3,t—Bu,CH.sub.2 c—Pr, (CH.sub.2 ) .sub.4 CH.sub.3, (CH.sub.2 ) .sub.2 CH (CH.sub.3 ) .sub.2 , CH (CH.sub.3 ) (CH.sub.2 ) .sub.2 CH.sub.3 , CH (CH.sub.2 CH.sub.3 ) CH.sub.2 C .sub.H3 , .sub.CH2 CH (.sub.CH3 ) .sub.CH2 CH3 , .sub.C (CH.sub.3 ) .sub.2 CH.sub.2 CH.sub.3 , CH.sub.2 t—Bu, CH.sub.2 C—BU, CH.sub.2 C — Pen,(CH.sub.2).sub.2c—Pr,(1-methylcyclopropyl)methyl,(2-methylcyclopropyl) methyl, 1-cyclopropylethyl, (eH.sub.2 ) .sub.3 c—Pr, (eH.sub.2 ) .sub.5 eH.sub.3, (eH.sub.2 ) .sub.3 eH (eH3) .sub.2, (eH.sub.2) .sub.2 eH (eH.sub.3) eH.sub.2 eH.sub.3, eH.sub.2 eH (eH.sub.3) ( CH.sub.2 ) .sub.2CH.sub.3 , CH (CH.sub.3 ) (CH.sub.2 ) .sub.3CH.sub.3 , CH.sub.2 CH (CH.sub.2 CH.sub.3 ) .sub.2 , heptyl, CH.sub.2 CH═CH.sub.2 , C H2 CH═CHCH3 , CH2 CH-C (CH3 ) 2 , CH2 CH═CF2 , CH2 CH═CC12 , CH2 CH═CHCH2 CH .sub.3, CH.sub.2CH═CH(CH.sub.2).sub.2CH.sub.3, CH.sub.2C(CH.sub.3)═CH.sub.2, CH.sub.2C(CH.sub.3)═CHCH.sub.3, CH.sub.2C(CH.sub.3) ═C(CH.sub.3).sub.2, CH.sub.2C(CH.sub.3)═CHCH.sub.2CH.sub.3, CH.sub.2CF═CH.sub.2, CH.sub.2CF═CHCH.sub.3, CH.sub.2CF═C(C H.sub.3).sub.2, CH.sub.2CF═CF.sub.2 , CH.sub.2CF═CHCH.sub.2CH.sub.3, CH.sub.2CF═CH(CH.sub.2).sub.2CH.sub.3, CH.sub.2CCl═CH.sub.2, CH.sub.2CCl═CHCH.sub.3, CH.sub.2CCl-C(CH.sub.3).sub.2, CH.sub.2CCl-CCl.sub.2, CH.sub.2CCl-CHCH.sub.2CH.sub.3, CH.sub.2 CCl═CH(CH.sub.2).sub.2CH.sub.3, (CH.sub.2).sub.2CH═CH.sub.2, (CH.sub.2).sub.2CH═CHCH.sub.3, (CH.sub.2).sub.2CH═CHCH.sub.2C H.sub.3, (CH.sub.2).sub.2CH═C(CH.sub.3).sub.2, (CH.sub.2).sub.2C(CH.sub.3)═CH.sub.2, (CH.sub.2).sub.2C(CH.sub.3)═CHCH.sub.3, (CH .sub.2).sub.3CH═CH.sub.2, (CH.sub.2).sub.3C(CH.sub.3)═CH.sub.2, (CH.sub.2).sub.4CH═CH.sub.2, CH.sub.2C≡CH, CH.sub.2C≡CCH3, C H.sub.2C≡CCH.sub.2CH.sub.3, CH.sub.2C≡Cc—Pr,(CH.sub.2).sub.2C≡CH, (CH.sub.2).sub.2C≡CCH.sub.3, (CH.sub.2).sub.2C≡CCH.sub.2CH.sub.3, (CH.sub.2).sub.3C≡CH,(CH.sub.2) .sub.3C≡CCH.sub.3, CH.sub.2Cl, CH.sub.2Br, CH.sub.2OCH.sub.3, CH.sub.2OCH.sub.2CH.sub.3, CH.sub.2O(CH.sub.2).sub.2CH.sub.3, CHF.sub.2, C F.sub.3, CH.sub.2CF.sub.3, CH.sub.2CHF.sub.2, CH.sub.2CH.sub.2CHF.sub.2, CH.sub.2CH.sub.2CF.sub.3, CH.sub.2CF.sub.2CF.sub.3, (CH.sub.2).sub.2CF.sub.2C F.sub.3, CH.sub.2(CF.sub.2).sub.2CF.sub.3, (CH.sub.2).sub.2CF(CF.sub.3).sub.2, (CH.sub.2).sub.2(CF.sub.2).sub.5CF.sub.3, CF.sub.3, CF.sub.2CHF(C F.sub.3).sub., CF.sub.2CHF(OCF.sub.3), and CH.sub.2CF.sub.2CF.sub.2H.

[0868] A compound (1A) wherein Q represents Q1, R.sup.1 represents a chlorine atom, and R.sup.7 represents any substituent selected from Group X (hereinafter, referred to as Compound class SX2).

[0869] A compound (1A) wherein Q represents Q1, R.sup.1 represents a fluorine atom, and R.sup.7 represents any substituent selected from Group X (hereinafter, referred to as Compound class SX3).

[0870] A compound (1A) wherein Q represents Q1, R.sup.1 represents an ethyl group, and R.sup.7 represents any substituent selected from Group X (hereinafter, referred to as Compound class SX4) .

[0871] A compound (1A) wherein Q represents Q1, R.sup.1 represents a cyclopropyl group, and R.sup.7 represents any substituent selected from Group X (hereinafter, referred to as Compound class SX5).

[0872] A compound (1A) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, and R.sup.7 represents any substituent selected from Group X (hereinafter, referred to as Compound class SX6).

[0873] A compound (1A) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, and R.sup.7 represents any substituent selected from Group X (hereinafter, referred to as Compound class SX7).

[0874] A compound (1A) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, and R.sup.7 represents any substituent selected from Group X (hereinafter, referred to as Compound class SX8).

[0875] A compound (1A) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, and R.sup.7 represents any substituent selected from Group X (hereinafter, referred to as Compound class SX9).

[0876] A compound represented by formula (1B):

##STR00132##

[0877] (hereinafter, referred to as “Compound (1B)”), [0878] wherein Q represents Q1, R.sup.1 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, P.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX10).

[0879] Combination A consists of Substituent Nos. ZA1 to ZA312. The Substituent No. ZA1 to ZA312 represents a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 in the compound (1B), a compound represented by formula (1D), a compound represented by formula (1F), a compound represented by formula (1I), a compound represented by formula (1M), a compound represented by formula (1N), a compound represented by formula (1O), a compound represented by formula (1P), a compound represented by formula (1Q), a compound represented by formula (1R), a compound represented by formula (1S), a compound represented by formula (1T), a compound represented by formula (2C), and a compound represented by formula (2E), , which hereinafter, is referred to as [Substituent No.; R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, R.sup.X6]. For example, Substituent No. ZA2 represents a combination wherein R.sup.X2 represents a methyl group, and R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represent a hydrogen atom.

Combination A

[0880] [ZA1;H, H, H, H, H], [ZA2; Me, H, H, H, H], [ZA3; F, H, H, H, H], [ZA4; Cl, H, H, H, H], [ZA5; OMe, H, H, H, H], [ZA6; CF.sub.3, H, H, H, H], [ZA7; H, Me, H, H, H], [ZA8; H, Et, H, H, H], [ZA9; H, Pr, H, H, H], [ZA10; H, i-Pr, H, H, H], [ZA11; H, t-Bu, H, H, H], [ZA12; H, OMe, H, H, H], [ZA13; H, OEt, H, H, H], [ZA14; H, OPr, H, H, H], [ZA15; H, Oi-Pr, H, H, H], [ZA16; H, CF.sub.3, H, H, H], [ZA17; H, CF.sub.2H, H, H, H], [ZA18; H, CF H.sub.2, H, H, H], [ZA19 ;H, F, H, H, H], [ZA20; H, Cl, H, H, H], [ZA21; H, Br, H, H, H], [ZA22; H, CN, H, H, H], [ZA23 ;H, Ph, H, H, H], [ZA24; H, OPh, H, H, H], [ZA25; H, c-Pr, H, H, H], [ZA26; H, c-Pen, H, H, H], [ZA27; H, c-Hex, H, H, H], [ZA28; H, H, Me, H, H], [ZA29; H, H, Et, H, H], [ZA30; H, H, Pr, H, H], [ZA31; H, H, i-Pr, H, H], [ZA32; H, H, t-Bu, H, H], [ZA33; H, H, OMe, H, H], [ZA34; H, H, OEt, H, H], [ZA35; H, H, OPr, H, H], [ZA36 ;H, H, Oi-Pr, H, H], [ZA37; H, H, CF.sub.3, H, H], [ZA38; H, H, CF.sub.2H, H, H], [ZA39; H, H, CF H.sub.2, H, H], [ZA40; H, H, F, H, H], [ZA41;H, H, Cl, H, H], [ZA42; H, H, Br, H, H ], [ZA43; H, H, CN, H, H], [ZA44; H, H, Ph, H, H], [ZA45; H, H, OPh, H, H], [Z A46; H, H, c-Pr, H, H], [ZA47; H, H, c-Pen, H, H], [ZA48; H, H, c-Hex, H, H], [ZA49; H, H, H, H, F], [ZA50; Me, H, H, H, F], [ZA51; F, H, H, H, F ], [ZA52; Cl, H, H, H, F], [ZA53; H, Me, H, H, F], [ZA54; H, Et, H, H, F], [ZA 55; H, Pr, H, H, F], [ZA56; H, i-Pr, H, H, F], [ZA57; H, t-Bu, H, H, F], [ZA58; H, OMe, H, H, F], [ZA59; H, OEt, H, H, F], [ZA60;H,OPr ,H, H, F], [ZA61; H, Oi-Pr, H, H, F], [ZA62; H, CF.sub.3, H, H, F], [ZA63; H, CF.sub.2H, H, H, F], [ZA64; H, CF H.sub.2, H, H, F], [ZA65; H, F, H, H, F], [ZA66; H, Cl, H, H, F], [ZA67; H, Br, H, H , F], [ZA68; H, CN, H, H, F], [ZA69; H, Ph, H, H, F], [ZA70; H, OPh, H, H, F], [ZA71; H, c-Pr, H, H, F], [ZA72; H, c-Pen, H, H, F], [ZA73; H, c-Hex, H, H, F], [ZA74; H, H, Me, H, F], [ZA75; H, H, Et, H, F], [ZA76; H, H, Pr , H, F], [ZA77; H, H, i-Pr, H, F], [ZA78; H, H, t-Bu, H, F], [ZA79; H, H, OMe, H, F], [ZA80; H, H, OEt, H, F], [ZA81; H, H, OPr , H, F], [ZA82; H, H, Oi-Pr, H, F], [ZA83; H, H, CF.sub.3, H, F], [ZA84; H, H, CF.sub.2H, H, F], [ZA85; H, H, CF H.sub.2, H, F], [ZA86; H, H, F, H, F], [ZA87; H, H, Cl, H, F], [ZA88; H, H, Br, H, F ], [ZA89; H, H, CN, H, F], [ZA90; H, H, Ph, H, F], [ZA91; H, H, OPh, H, F], [Z A92; H, H, c-Pr, H, F], [ZA93; H, H, c-Pen, H, F], [ZA94; H, H, c-Hex, H, F], [ZA95; H, H, H, H, Cl], [ZA96; Me, H, H, H, Cl], [ZA97; F, H, H, H , Cl], [ZA98; Cl, H, H, H, Cl], [ZA99; H, Me, H, H, Cl], [ZA100; H, Et, H, H, Cl], [ZA101; H, Pr, H, H, Cl], [ZA102; H, i-Pr, H, H, Cl], [ZA103; H, t-Bu, H, H, Cl], [ZA104; H, OMe, H, H, Cl], [ZA105; H, OEt, H, H, Cl], [ZA106 ; H, OPr, H, H, Cl], [ZA107; H, Oi-Pr, H, H, Cl], [ZA108; H, CF.sub.3, H, H, Cl], [ZA109; H, CF.sub.2H, H, H, Cl], [ZA11 0; H, CFH.sub.2, H, H, C1], [ZA111; H, F, H, H, C1], [ZA112; H, C1, H, H, C1], [ZA 113; H, Br, H, H, Cl], [ZA114; H, CN, H, H, Cl], [ZA115; H, Ph, H, H, Cl], [Z A116; H, OPh, H, H, Cl], [ZA117; H, c-Pr, H, H, Cl], [ZA118; H, H, H, F, F], [ZA119; F, H, H, F, F], [ZA120; H, H, M e, H, Cl], [ZA121; H, H, Et, H, Cl], [ZA122; H, H, Pr, H, Cl], [ZA123; H, H, i-Pr, H, Cl], [ZA124; H, H, t-Bu, H,Cl], [ZA125; H, H, OMe, H, Cl], [ZA126; H, H, OEt, H, Cl], [ZA127; H, H, OPr, H, Cl], [ZA128; H, H, Oi-Pr, H, Cl], [ZA129; H, H, CF.sub.3, H, Cl], [ZA130; H, H, CF.sub.2H, H, Cl], [ZA131; H, H, CFH.sub.2, H, Cl], [ZA132;H, H, F, H, Cl], [ZA133; H, H, Cl, H, Cl], [ZA13 4; H, H, Br, H, Cl], [ZA135; H, H, CN, H, Cl], [ZA136; H, H, Ph, H, Cl], [ZA1 37; H, H, OPh, H, Cl], [ZA138; H, H, c-Pr, H, Cl], [ZA139; H, H, c-Pen, H, Cl], [ZA140; H, H, c-Hex, H, Cl], [ZA141; H, H, H, H, Me], [ZA142; Me, H, H, H, Me], [ZA143; F, H, H, H, Me], [ZA144; Cl, H, H, H, Me], [ZA145; H, Me, H, H, Me], [ZA146; H, E t, H, H, Me], [ZA147; H, Pr, H, H, Me], [ZA148; H, i-Pr, H, H, Me], [ZA149; H, t-Bu, H, H, Me], [ZA150; H, OMe, H, H, Me], [ZA151; H, OEt, H, H, Me], [ZA152; H, OPr, H, H, Me], [ZA153; H, Oi-Pr, H, H, Me], [ZA154; H, CF.sub.3, H, H, Me], [ZA155; H, CF.sub.2H, H, H, Me], [ZA15 6; H, CFH.sub.2, H, H, Me], [ZA157; H, F, H, H, Me], [ZA158; H, Cl, H, H, Me], [ZA 159; H, Br, H, H, Me], [ZA160; H, CN, H, H, Me], [ZA161; H, Ph, H, H, Me], [Z A162; H, OPh, H, H, Me], [ZA163; H, c-Pr, H, H, Me], [ZA164; H, c-Pen, H, H, Me], [ZA165; H, c-Hex, H, H, Me], [ZA166; H, H, Me, H, Me], [ZA167; H, H, Et, H, Me], [ZA168; H, H, Pr, H, Me], [ZA169; H, H, i-Pr, H, Me], [ZA170; H, H, t-Bu, H, Me], [ZA171; H, H, OMe, H, Me], [ZA172; H, H, OEt, H, Me], [ZA173; H, H, OPr, H, Me], [ZA174; H, H, Oi-Pr, H, Me], [ZA175; H, H, CF.sub.3, H, Me], [ZA176; H, H, CF.sub.2H, H, Me], [ZA177; H, H, CFH.sub.2,H, Me], [ZA178; H, H, F, H, Me], [ZAI79; H, H, Cl, H, Me], [ZA18 0; H, H, Br, H, Me], [ZA181; H, H, CN, H, Me], [ZA182; H, H, Ph, H, Me], [ZA1 83; H, H, OPh, H, Me], [ZA184; H, H, c-Pr, H, Me], [ZA185; H, H, c-Pen, H, Me], [ZA186; H, H, c-Hex, H, Me],[ZA187; H, H, H, H, OMe], [ZA188; Me, H, H, H, OMe], [ZA189; F, H, H, H, OMe], [ZA190; Cl, H, H, H, OMe], [ZA191; H, Me, H, H, OMe], [ZA19 2; H, Et, H, H, OMe], [ZA193; H, Pr, H, H, OMe], [ZA194; H, i-Pr, H, H, OMe], [ZA195; H, t-Bu, H, H, OMe], [ZA196; H, OMe, H, H, OMe], [ZA197; H, OEt, H, H, OMe], [ZA 198; H, OPr, H, H, OMe], [ZA199; H, Oi-Pr, H, H, OMe], [ZA200; H, CF.sub.3, H, H, OMe], [ZA201; H, CF.sub.2H, H, H, OMe], [ZA202; H, CFH.sub.2, H, H, OMe], [ZA203; H, F, H, H, OMe], [ZA204; H, Cl, H, H, OMe], [ZA205; H, Br, H, H, OMe], [ZA206; H, C N, H, H, OMe], [ZA207; H, Ph, H, H, OMe], [ZA208; H, OPh, H, H, OMe], [ZA20 9; H, c-Pr, H, H, OMe], [ZA210; H, c-Pen, H, H, OMe], [ZA211; H, c-Hex, H, H, OMe], [ZA212; H, H, Me, H, OMe], [ZA213; H, H, Et, H, OMe], [ZA2 14; H, H, Pr, H, OMe], [ZA215; H, H, i-Pr, H, OMe], [ZA216; H, H, t-Bu, H, OMe], [ZA217; H, H, OMe, H, OMe], [ZA218; H, H, OEt, H, OMe], [ZA21 9; H, H, OPr, H, OMe],[ZA220; H, H, Oi-Pr, H, OMe], [ZA221; H, H, CF.sub.3,H, OMe], [ZA222; H, H, CF.sub.2H, H, OMe], [ZA2 23; H, H, CFH.sub.2, H, OMe], [ZA224; H, H, F, H, OMe], [ZA225; H, H, Cl, H, OMe], [ZA226; H, H, Br, H, OMe], [ZA227; H, H, CN, H, OMe], [ZA228; H, H, Ph, H, OMe], [ZA229; H, H, OPh, H, OMe], [ZA230; H, H, c-Pr, H, OMe], [ZA231; H, H, c-Pen, H, OMe], [ZA232; H, H, c-Hex, H, OMe], [ZA233; H, H, H, H, CF.sub.3, [ZA234; Me, H, H, H, CF.sub.3], [ZA235; F, H, H, H, CF.sub.3], [ZA236; Cl, H, H, H, CF.sub.3], [ZA237; H, Me, H, H, CF.sub.3], [ZA23 8; H, Et, H, H, CF.sub.3], [ZA239; H, Pr, H, H, CF.sub.3], [ZA240; H, i-Pr,H,H,CF.sub.3], [ZA241;H,t-Bu, H, H, CF.sub.3], [ZA242; H, OMe, H, H, CF.sub.3], [ZA243; H, OEt, H, H, CF.sub.3], [ZA2 44; H, OPr, H, H, CF.sub.3], [ZA245; H,Oi-Pr, H, H, CF.sub.3], [ZA246; H, CF.sub.3, H, H, CF.sub.3], [ZA247; H, CF.sub.2H, H, H, CF.sub.3], [ZA 248; H, CFH.sub.2, H, H, CF.sub.3], [ZA249; H, F, H, H, CF.sub.3], [ZA250; H, Cl, H, H, CF.sub.3] [ZA251; H, Br, H, H, CF.sub.3], [ZA252; H, CN, H, H, CF.sub.3], [ZA253; H, Ph, H, H, CF.sub.3], [ZA254; H, OPh, H, H, CF.sub.3], [ZA255; H, c-Pr, H, H, CF.sub.3], [ZA256; H, c-Pen, H, H, CF.sub.3], [ZA257; H, c-Hex, H, H, CF.sub.3], [ZA258; H, H, Me, H, CF.sub.3], [ZA259; H, H, Et, H, CF.sub.3], [ZA26 0; H, H, Pr, H, CF.sub.3], [ZA261; H, H, i-Pr, H, CF.sub.3], [ZA262; H, H, t-Bu, H, CF.sub.3], [ZA263; H, H, OMe, H, CF.sub.3], [ZA264; H, H, OEt, H, CF.sub.3], [ZA265; H, H, OPr, H, CF.sub.3], [ZA266; H, H, Oi-Pr, H, CF.sub.3], [ZA267; H, H, CF.sub.3, H, CF.sub.3], [ZA268; H, H, CF.sub.2H, H, CF.sub.3], [ZA26 9; H, H, CFH.sub.2, H, CF.sub.3], [ZA270; H, H, F, H, CF.sub.3], [ZA271; H, H, Cl, H, CF.sub.3], [ ZA272; H, H, Br, H, CF.sub.3], [ZA273; H, H, CN, H, CF.sub.3], [ZA274; H, H, Ph, H, CF.sub.3 ], [ZA275; H, H, OPh, H, CF.sub.3], [ZA276; H, H, c-Pr, H, CF.sub.3], [ZA277; H, H, c-Pen, H, CF.sub.3], [ZA278; H, H, c-Hex, H, CF.sub.3], [ZA279; H, F, F, H, H], [ZA280; H, F, H, F, H], [ZA281; H, F, F, F, H], [ZA282; F, F, F, H, H], [ZA283; F, F, H, F, H], [ZA284; F, H, F, H, F], [ZA285; F, F, F, F, F], [ZA286; F, F, H, F, F], [ZA287; H, OMe, H, OMe, H], [ZA288; H, F, Cl, H, H], [ZA289; H, F, Me, H, H], [ZA290; H, F, OMe, H, H], [ ZA291; H, F, CF.sub.3, H, H], [ZA292; H, Cl, F, H, H], [ZA293; H, Cl, Cl, H, H], [ ZA294; H, Cl, Me, H, H], [ZA295; H, Cl, OMe, H, H], [ZA296; H, Cl, CF.sub.3,H, H ], [ZA297; H, Me, F, H, H], [ZA298; H, Me, Cl, H, H], [ZA299; H, Me, Me, H, H ], [ZA300; H, Me, OMe, H, H], [ZA301; H, Me, CF.sub.3, H, H], [ZA302; H, OMe, F, H, H], [ZA303; H, OMe, Cl, H, H], [ZA304; H, OMe, Me, H, H], [ZA305; H, OMe, OMe, H, H], [ZA306; H, OMe, CF.sub.3, H, H], [ZA307; H, CF.sub.3, F, H, H], [ZA308; H, CF.sub.3, Cl, H, H],[ZA309; H, C F.sub.3, F, H, H], [ZA310; H, CF.sub.3, Cl, H, H], [ZA311; H, CF.sub.3, F, H, H], [ZA312; H, Cl, H, Cl, H]

[0881] A compound (1B) wherein Q represents Q1, R.sup.1 represents a chlorine atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX11).

[0882] A compound (1B) wherein Q represents Q1, R.sup.1 represents a fluorine atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX12).

[0883] A compound (1B) wherein Q represents Q1, R.sup.1 represents an ethyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX13).

[0884] A compound (1B) wherein Q represents Q1, R.sup.1 represents a cyclopropyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX14).

[0885] A compound (1B) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX15).

[0886] A compound (1B) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX16).

[0887] A compound (1B) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX17) .

[0888] A compound (1B) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX18).

[0889] A compound represented by formula (1C):

##STR00133##

[0890] (hereinafter, referred to as “Compound (1C)”), [0891] wherein R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX19).

[0892] A compound (1C) wherein Q represents Q1, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX20).

[0893] A compound (1C) wherein Q represents Q1, R.sup.1 represents a fluorine atom, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX21).

[0894] A compound (1C) wherein Q represents Q1, R.sup.1 represents an ethyl group, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX22).

[0895] A compound (1C) wherein Q represents Q1, R.sup.1 represents a cyclopropyl group, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX23).

[0896] A compound (1C) wherein Q represents Q1, R.sup.1 represents a methyl group, R.sup.4 represents an ethyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX24).

[0897] A compound (1C) wherein Q represents Q1, R.sup.1 represents a chlorine atom, R.sup.4 represents an ethyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX25).

[0898] A compound (1C) wherein Q represents Q1, R.sup.1 represents a fluorine atom, R.sup.4 represents an ethyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX26).

[0899] A compound (1C) wherein Q represents Q1, R.sup.1 represents an ethyl group, R.sup.4 represents an ethyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX27).

[0900] A compound (1C) wherein Q represents Q1, R.sup.1 represents a cyclopropyl group, R.sup.4 represents an ethyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX28).

[0901] A compound (1C) wherein Q represents Q1, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX29).

[0902] A compound (1C) wherein Q represents Q1, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX30).

[0903] A compound (1C) wherein Q represents Q1, R.sup.1 represents a fluorine atom, R.sup.4 represents a hydrogen atom, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX31).

[0904] A compound (1C) wherein Q represents Q1, R.sup.1 represents an ethyl group, R.sup.4 represents a hydrogen atom, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX32).

[0905] A compound (1C) wherein Q represents Q1, R.sup.1 represents a cyclopropyl group, R.sup.4 represents a hydrogen atom, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX33).

[0906] A compound (1C) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX34) .

[0907] A compound (1C) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX35) .

[0908] A compound (1C) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX36).

[0909] A compound (1C) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, R.sup.4 represents an ethyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX37) .

[0910] A compound (1C) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX38) .

[0911] A compound (1C) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX39) .

[0912] A compound (1C) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX40).

[0913] A compound (1C) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX41).

[0914] A compound (1C) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, R.sup.4 represents an ethyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX42).

[0915] A compound (1C) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, R.sup.4 represents an ethyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX43).

[0916] A compound (1C) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX44).

[0917] A compound (1C) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX45).

[0918] A compound represented by formula (1D):

##STR00134##

[0919] (hereinafter, referred to as “Compound (1D)”), [0920] wherein Q represents Q1, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.x3, R.sup.X4, R.sup.x5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX46) .

[0921] A compound (1D) wherein Q represents Q1, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX47).

[0922] A compound (1D) wherein Q represents Q1, R.sup.1 represents a fluorine atom, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX48).

[0923] A compound (1D) wherein Q represents Q1, R.sup.1 represents an ethyl group, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.x3, R.sup.X4, R.sup.x5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX49).

[0924] A compound (1D) wherein Q represents Q1, R.sup.1 represents a cyclopropyl group, R.sup.4 represents a methyl group, and a combination of R.sup.x2, R.sup.x3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX50).

[0925] A compound (1D) wherein Q represents Q1, R.sup.1 represents a methyl group, R.sup.4 represents an ethyl group, and a combination of R.sup.X2, R.sup.x3, R.sup.x4, R.sup.X5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX51).

[0926] A compound (1D) wherein Q represents Q1, R.sup.1 represents a chlorine atom, R.sup.4 represents an ethyl group, and a combination of R.sup.X2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX52).

[0927] A compound (1D) wherein Q represents Q1, R.sup.1 represents a fluorine atom, R.sup.4 represents an ethyl group, and a combination of R.sup.x2, R.sup.x3, R.sup.X4, R.sup.X5, and R.sup.x6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX53).

[0928] A compound (1D) wherein Q represents Q1, R.sup.1 represents an ethyl group, R.sup.4 represents an ethyl group, and a combination of R.sup.X2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX54).

[0929] A compound (1D) wherein Q represents Q1, R.sup.1 represents a cyclopropyl group, R.sup.4 represents an ethyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.x5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX55).

[0930] A compound (1D) wherein Q represents Q1, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and a combination of R.sup.x2, R.sup.x3, R.sup.X4,R.sup.X5, and R.sup.x6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX56).

[0931] A compound (1D) wherein Q represents Q1, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, .sub.and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX57).

[0932] A compound (1D) wherein Q represents Q1, R.sup.1 represents a fluorine atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX58).

[0933] A compound (1D) wherein R.sup.1 represents an ethyl group R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.x3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX59) .

[0934] A compound (1D) wherein Q represents Q1, R.sup.1 represents a cyclopropyl group, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX60).

[0935] A compound (1D) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.x3, R.sup.X4, R.sup.x5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX61).

[0936] A compound (1D) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX62).

[0937] A compound (1D) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, R.sup.4 represents an ethyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.x6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX63).

[0938] A compound (1D) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, R.sup.4 represents an ethyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX64).

[0939] A compound (1D) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX65).

[0940] A compound (1D) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX66).

[0941] A compound (1D) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX67).

[0942] A compound (1D) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group and a combination of R.sup.X2, R.sup.x3, R.sup.X4, R.sup.x5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX68).

[0943] A compound (1D) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, R.sup.4 represents an ethyl group and a combination of R.sup.X2, R.sup.x3, R.sup.X4, R.sup.X5, and R.sup.x6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX69).

[0944] A compound (1D) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, R.sup.4 represents an ethyl group and a combination of R.sup.X2, R.sup.x3, R.sup.X4, R.sup.x5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX70).

[0945] A compound (1D) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom and a combination of R.sup.x2, R.sup.X3, R.sup.X4, R.sup.x5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX71).

[0946] A compound (1D) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX72).

[0947] A compound represented by formula (1E):

##STR00135##

[0948] (hereinafter, referred to as “Compound (1E)”), [0949] wherein Q represents Q1, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and R.sup.8 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX73).

[0950] A compound (1E) wherein Q represents Q1, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group, and R.sup.8 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX74).

[0951] A compound (1E) wherein Q represents Q1, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and R.sup.8 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX75).

[0952] A compound (1E) wherein Q represents Q1, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and R.sup.8 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX76).

[0953] A compound (1E) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and R.sup.8 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX77) .

[0954] A compound (1E) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group, and R.sup.8 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX78) .

[0955] A compound (1E) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and R.sup.8 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX79) .

[0956] A compound (1E) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and R.sup.8 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX80) .

[0957] A compound (1E) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and R.sup.8 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX81).

[0958] A compound (1E) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group, and R.sup.8 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX82).

[0959] A compound (1E) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and R.sup.8 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX83).

[0960] A compound (1E) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and R.sup.8 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX84).

[0961] A compound represented by formula (1F):

##STR00136##

[0962] (hereinafter, referred to as “Compound (1F)”), [0963] wherein Q represents Q1, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and a combination of R.sup.x2, R.sup.X3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX85) .

[0964] A compound (1F) wherein Q represents Q1, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.x3, R.sup.X4, R.sup.x5, and R.sup.x6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX86).

[0965] A compound (1F) wherein Q represents Q1, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.x5, and R.sup.x6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX87).

[0966] A compound (1F) wherein Q represents Q1, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.x3, R.sup.x4, R.sup.X5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX88).

[0967] A compound (1F) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX89).

[0968] A compound (1F) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX90).

[0969] A compound (1F) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and a combination of R.sup.x2, R.sup.X3, R.sup.X4, R.sup.x5, and R.sup.x6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX91).

[0970] A compound (1F) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.x3, R.sup.X4, R.sup.X5, and R.sup.x6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX92).

[0971] A compound (1F) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.x3, R.sup.x4, R.sup.X5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX93).

[0972] A compound (1F) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group, and a combination of R.sup.x2, R.sup.x3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX94).

[0973] A compound (1F) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX95).

[0974] A compound (1F) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.x3, R.sup.x4, R.sup.X5, and R.sup.X6 represents any combinations described in the combination A (hereinafter, referred to as Compound Class SX96).

[0975] A compound represented by formula (1G):

##STR00137##

[0976] (hereinafter, referred to as “Compound (1G)”), [0977] wherein Q represents Q1, R.sup.1 represents a methyl group, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound Class SX97).

[0978] Group Y: a group consisting of Et,Pr,i— Pr, (CH.sub.2 ) .sub.3CH.sub.3 , CH.sub.2 CH (CH.sub.3 ) .sub.2,CH (CH.sub.3 ) CH.sub.2CH.sub.3 , t-Bu,CH.sub.2 c-Pr, (CH.sub.2 ) .sub.4 CH.sub.3 , (CH.sub.2 ) .sub.2 CH (CH.sub.3 ) .sub.2 , CH (CH.sub.3) (CH.sub.2 ) .sub.2 CH.sub.3 , CH (CH.sub.2 CH.sub.3 ) CH.sub.2 C H.sub.3 ,CH.sub.2 CH (CH.sub.3 ) CH.sub.2 CH.sub.3 ,C(CH.sub.3 ) .sub.2 CH.sub.2 CH.sub.3 , CH.sub.2 t-Bu, CH.sub.2 C-B.sub.U, CH.sub.2 C-Pen, (CH.sub.2).sub.2c-Pr, (1-methylcyclopropyl)methyl, (2-methylcyclopropyl)methyl,1-cyclopropylethyl, (CH.sub.2).sub.3C-Pr, (CH.sub.2).sub.5 CH.sub.3, (CH.sub.2).sub.3CH(CH.sub.3).sub.2, (CH.sub.2 ).sub.2 CH(CH.sub.3)CH.sub.2CH.sub.3,CH.sub.2CH(CH.sub.3) ( CH.sub.2 ) .sub.2 CH.sub.3 , CH (CH.sub.3 ) (CH.sub.2 ) .sub.3 CH.sub.3 , CH.sub.2 CH (CH.sub.2 CH.sub.3 ) .sub.2 , heptyl, CH.sub.2 CH═CH.sub.2 H.sub.2 CH═CHCH.sub.3 , CH.sub.2 CH═C (CH.sub.3 ) .sub.2 , CH.sub.2 CH═CF.sub.2 , CH.sub.2 CH═CC1.sub.2 , CH.sub.2 CH═CHCH.sub.2 CH .sub.3 , CH.sub.2 CH═CH (CH.sub.2 ) .sub.2 CH.sub.3 , CH.sub.2 C (CH.sub.3 ) ═CH.sub.2 , CH.sub.2C (CH.sub.3 ) ═CHCH.sub.3 , CH.sub.2 C (CH.sub.3 ) ═C(CH.sub.3 ).sub.2 , CH.sub.2 C(CH.sub.3)═CHCH.sub.2 CH.sub.3 , CH.sub.2 CF═CH.sub.2,CH.sub.2 CF═CHCH.sub.3,CH.sub.2 CF═C(C H.sub.3 ) .sub.2 , CH.sub.2 CF═CF.sub.2 , CH.sub.2 CF═CHCH.sub.2 CH.sub.3 , CH.sub.2 CF═CH (CH.sub.2 ) .sub.2 CH.sub.3 , CH.sub.2 CC1═CH.sub.2 , CH.sub.2CCl═CHCH.sub.3,CH.sub.2CCl═C(CH.sub.3).sub.2,CH.sub.2CCl═CCl.sub.2,CH.sub.2CCl═CHCH.sub.2CH.sub.3,CH.sub.2 CCl═CH (CH.sub.2 ).sub.2CH.sub.3, (CH.sub.2 ).sub.2CH═CH.sub.2 , (CH.sub.2 ) .sub.2CH═CHCH.sub.3, (CH.sub.2 ).sub.2 CH═CHCH.sub.2C H.sub.3 , (CH.sub.2 ).sub.2CH═C (CH.sub.3 ) .sub.2 , (CH.sub.2 ) .sub.2 C (CH.sub.3 )═CH.sub.2 , (CH.sub.2 ) .sub.2C (CH.sub.3 ) ═CHCH.sub.3 , (CH .sub.2 ) .sub.3 CH═CH.sub.2 , (CH.sub.2 ) .sub.3C (CH.sub.3 ) ═CH.sub.2 , (CH.sub.2 ) .sub.4 CH═CH.sub.2 ,CH.sub.2 C═CH, CH.sub.2C═CCH.sub.3 , C H.sub.2C═CCH.sub.2CH.sub.3 , CH.sub.2C═Cc—Pr, (CH2 ).sub.2 C═CH, (CH.sub.2 ) .sub.2 C═CCH3 , (CH.sub.2 ) .sub.2 C═CCH.sub.2 CH.sub.3 , (CH.sub.2) .sub.3 C═CH, (CH.sub.2 ) .sub.3 C═ CCH.sub.3 , CH.sub.2 C1, CH.sub.2 Br, CH.sub.2 OCH.sub.3 , CH.sub.2 0CH.sub.2 CH.sub.3 , CH.sub.2CH.sub.2OCH.sub.3 , CH.sub.2 O (CH.sub.2 ) .sub.2 CH.sub.3 , CHF.sub.2 , CF.sub.3 , CH.sub.2 CF.sub.3 , CH.sub.2 CHF.sub.2 , CH.sub.2 CH.sub.2 F, CH.sub.2 CH.sub.2 CH.sub.2 F, CH.sub.2 CH.sub.2 CHF.sub.2 , CH.sub.2 C H.sub.2CF.sub.3 ,CH.sub.2 CF.sub.2 CF.sub.3 , (CH.sub.2 ) .sub.2CF.sub.2 CF.sub.3 , CH.sub.2 (CF.sub.2 ) .sub.2 CF.sub.3 , (CH.sub.2 ) .sub.2CF (CF.sub.3 ) .sub.2, (C H.sub.2 ) .sub.2 (CF.sub.2 ) .sub.5 CF.sub.3 , CF.sub.3 , CF.sub.2 CHF (CF.sub.3 ) , CF.sub.2CHF (OCF.sub.3 ) , CH.sub.2 CF.sub.2 CF.sub.2 H, c—Pr, and c—Bu.

[0979] A compound (1G) wherein Q represents Q1, R.sup.1 represents a chlorine atom, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound Class SX98).

[0980] A compound (1G) wherein Q represents Q1, R.sup.1 represents a fluorine atom, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound Class SX99).

[0981] A compound (1G) wherein Q represents Q1, R.sup.1 represents an ethyl group, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound Class SX100).

[0982] A compound (1G) wherein Q represents Q1, R.sup.1 represents a cyclopropyl group, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound Class SX101).

[0983] A compound (1G) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound Class SX102).

[0984] A compound (1G) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound Class SX103).

[0985] A compound (1G) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound Class SX104).

[0986] A compound (1G) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound Class SX105).

[0987] A compound represented by formula (1H):

##STR00138##

[0988] (hereinafter, referred to as “Compound (1H)”) , [0989] wherein Q represents Q1, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and R.sup.13 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX106).

[0990] A compound (1H) wherein Q represents Q1, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group, and R.sup.13 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX107).

[0991] A compound (1H) wherein Q represents Q1, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and R.sup.13 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX108).

[0992] A compound (1H) wherein Q represents Q1, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and R.sup.13 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX109).

[0993] A compound (1H) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and R.sup.13 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX110) .

[0994] A compound (1H) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group, and R.sup.13 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX111) .

[0995] A compound (1H) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and R.sup.13 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX112).

[0996] A compound (1H) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and R.sup.13 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX113) .

[0997] A compound (1H) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and R.sup.13 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX114).

[0998] A compound (1H) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group, and R.sup.13 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX115).

[0999] A compound (1H) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and R.sup.13 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX116).

[1000] A compound (1H) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and R.sup.13 represents any substituents selected from Group X (hereinafter, referred to as Compound Class SX117).

[1001] A compound represented by formula (1I):

##STR00139##

(hereinafter, referred to as “Compound (1I)”) wherein Q represents Q1, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX118).

[1002] A compound (1I) wherein Q represents Q1, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5 , and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX119).

[1003] A compound (1I) wherein Q represents Q1, R.sup.1 represents a methyl group, R.sup.4 represents an ethyl group, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX120).

[1004] A compound (1I) wherein Q represents Q1, R.sup.1 represents a chlorine atom, R.sup.4 represents an ethyl group, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX121).

[1005] A compound (1I) wherein Q represents Q1, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX122).

[1006] A compound (1I) wherein Q represents Q1, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX123).

[1007] A compound (1I) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX124).

[1008] A compound (1I) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX125).

[1009] A compound (1I) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, R.sup.4 represents an ethyl group, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX126).

[1010] A compound (1I) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, R.sup.4 represents an ethyl group, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX127).

[1011] A compound (1I) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX128).

[1012] A compound (1I) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX129).

[1013] A compound (1I) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, R.sup.4 represents a methyl group, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX130).

[1014] A compound (1I) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, R.sup.4 represents a methyl group, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX131).

[1015] A compound (1I) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, R.sup.4 represents an ethyl group, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX132).

[1016] A compound (1I) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, R.sup.4 represents an ethyl group, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX133).

[1017] A compound (1I) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, R.sup.4 represents a hydrogen atom, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX134).

[1018] A compound (1I) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.x2, R.sup.x3, R.sup.x4, R.sup.x5, and R.sup.x6 represents any substituents selected from Group A (hereinafter, referred to as Compound class SX135).

[1019] A compound represented by formula (1J):

##STR00140##

[wherein G represents any one of formulae G1 to formula G35.

##STR00141##

##STR00142##

##STR00143##

##STR00144##

##STR00145##

##STR00146##

##STR00147##

##STR00148##

##STR00149##

##STR00150##

##STR00151##

##STR00152##

##STR00153##

##STR00154##

##STR00155##

##STR00156##

##STR00157##

##STR00158##

##STR00159##

##STR00160##

##STR00161##

##STR00162##

##STR00163##

##STR00164##

##STR00165##

##STR00166##

##STR00167##

##STR00168##

##STR00169##

##STR00170##

##STR00171##

##STR00172##

##STR00173##

##STR00174##

##STR00175##

] (hereinafter, referred to as “Compound (1J)”) wherein Q represents Q1, R.sup.1 represents a methyl group, and a combination of structure of G and substituents of R.sup.x7, R.sup.x8, R.sup.x9 and R.sup.x10 applied to the structure of G represents any combination described in Combination B (hereinafter, referred to as Compound class SX136).

[1020] Combination B consists of substituent numbers ZB1 to ZB1539.

[1021] Substituent numbers ZB1 to ZB1539 represent combinations of structure of G and substituents of R.sup.X7, R.sup.x8, R.sup.x9 and R.sup.x10 applied to the structure of G according to Compound (1J), which hereinafter, is referred to as [Substituent No.; G, R.sup.x7, R.sup.x8, R.sup.x9, R.sup.x10] . For example, Substituent No. ZB2 represents a combination wherein G represents G1, R.sup.x7 represents a methyl group, and R.sup.x8, R.sup.x9, and R.sup.x10 represent a hydrogen atom.

Combination B

[1022] [ZB1;G1,H,H,H,H],[ZB2;G1,Me,H,H,H],[ZB3;G1,Et,H,H,H],[ZB4;G 1,Pr,H,H,H] , [ZB5;G1,i-Pr,H,H,H] , [ZB6;G1,c-Pr,H,H,H],[ZB7;G1,Ph,H,H,H] , [ZB8;G1,OMe,H,H,H],[ZB9;G1,OEt, H,H,H] , [ZB10;G1,OPh,H,H,H] , [ZB11;G1,CF.sub.3,H,H,H] , [ZB12;G1,F,H ,H,H],[ZB13;G1,Cl,H,H,H] , [ZB14;G1,Br,H,H,H] , [ZB15;G1,CN,H,H ,H] , [ZB16;G1,H,Me,H,H] , [ZB17;G1,H,Et,H,H] , [ZB18;G1,H,Pr,H,H ] , [ZB19; G1,H,i-Pr,H,H] , [ZB20;G1,H,c-Pr,H,H] , [ZB21;G1,H,Ph,H,H] , [ZB22;G1,H,OMe,H,H] , [ZB23;G1,H,O Et,H,H] , [ZB24;G1,H,OPh,H,H] , [ZB25;G1,H,CF.sub.3,H,H] , [ZB26;G1,H, F,H,H] , [ZB27;G1,H,Cl,H,H] , [ZB28;G1,H,Br,H,H] , [ZB29;G1,H,eN, H,H] , [ZB30;G1,H,H,Me,H] , [ZB31;G1,H,H,Et,H] , [ZB32;G1,H,H,Pr, H] , [ZB33;G1,H,H,i-Pr,H] , [ZB34;G1,H,H,c-Pr,H] , [ZB35;G1,H,H,Ph,H] , [ZB36;G1,H,H,OMe,H] , [ZB37;G1,H,H,O Et,H] , [ZB38;G1,H,H,OPh,H] , [ZB39;G1,H,H,CF.sub.3,H] , [ZB40;G1,H,H, F,H] , [ZB41;G1,H,H,Cl,H] , [ZB42;G1,H,H,Br,H] , [ZB43;G1,H,H,CN, H] , [ZB44;G1,H,H,H,Me] , [ZB45;G1,H,H,H,Et] , [ZB46;G1,H,H,H,Pr] , [ZB47;G1,H,H,H,i-Pr] , [ZB98;G1,H,H,H,c-Pr] , [ZB49;G1,H,H,H,Ph] , [ZB50;G1,H,H,H,OMe] , [ZB51;G1,H,H,H,O Et] , [ZB52;G1,H,H,H,OPh] , [ZB53;G1,H,H,H,CF.sub.3] , [ZB54;G1,H,H,H, F] , [ZB55;G1,H,H,H,Cl] , [ZB56;G1,H,H,H,Br] , [ZB57;G1,H,H,H,CN] , [ZB58;G2,H,H,H,H] , [ZB59;G2,Me,H,H,H] , [ZB60;G2,Et,H,H,H] , [Z B61;G2,Pr,H,H,H] , [ZB62;G2,i-Pr,H,H,H] , [ZB63;G2,c-Pr,H,H,H] , [ZB64;G2,Ph,H,H,H] , [ZB65;G2,OMe,H,H,H] , [ZB66;G2,O Et,H,H,H] , [ZB67;G2,OPh,H,H,H] , [ZB68;G2,CF.sub.3,H,H,H] , [ZB69;G2, F,H,H,H] , [ZB70;G2,Cl,H,H,H] , [ZB71;G2,Br,H,H,H] , [ZB72;G2,CN, H,H,H] , [ZB73;G2,H,Me,H,H] , [ZB74;G2,H,Et,H,H] , [ZB75;G2,H,Pr, H,H] , [ZB76;G2,H,i-Pr,H,H] , [ZB77;G2,H,c-Pr,H,H] , [ZB78;G2,H,Ph,H,H] , [ZB79;G2,H,OMe,H,H] , [ZB80;G2,H,O Et,H,H] , [ZB81;G2,H,OPh,H,H] , [ZB82;G2,H,CF.sub.3,H,H] , [ZB83;G2,H, F,H,H] , [ZB84;G2,H,Cl,H,H] , [ZB85;G2,H,Br,H,H] , [ZB86;G2,H,CN, H,H] , [ZB87;G2,H,H,Me,H] , [ZB88;G2,H,H,Et,H] , [ZB89;G2,H,H,Pr, H] , [ZB90;G2,H,H,i-Pr,H] , [ZB91;G2,H,H,c-Pr,H] , [ZB92;G2,H,H,Ph,H] , [ZB93;G2,H,H,OMe,H] , [ZB94;G2,H,H,O Et,H] , [ZB95:G2,H,H,OPh,H] , [ZB96;G2,H,H,CF.sub.3,H] , [ZB97;G2,H,H, F,H] , [ZB98;G2,H,H,Cl,H] , [ZB99;G2,H,H,Br,H] , [ZB100;G2,H,H,CN ,H] , [ZB101;G2,H,H,H,Me] , [ZB102;G2,H,H,H,Et] , [ZB103;G2,H,H,H ,Pr] , [ZB104;G2,H,H,H,i-Pr] , [ZB105;G2,H,H,H,c-Pr] , [ZB106;G2,H,H,H,Ph] , [ZB107;G2,H,H,H,OMe] , [ZB108;G2,H,H, H,OEt] , [ZB109;G2,H,H,H,OPh] , [ZB110;G2,H,H,H,CF.sub.3] , [ZB111;G2, H,H,H,F] , [ZB112;G2,H,H,H,Cl] , [ZB113;G2,H,H,H,Br] , [ZB114;G2, H,H,H,CN] , [ZB115;G3,H,H,H,H] , [ZB116;G3,Me,H,H,H] , [ZB117;G3, Et,H,H,H] , [ZB118;G3,Pr,H,H,H] , (ZB119;G3,i-Pr,H,H,H] , [ZB120;G3,c-Pr,H,H,H] , [ZB121;G3,Ph,H,H,H] , [ZB122;G3,OMe,H,H,H] , [ZB123;G 3,OEt,H,H,H] , [ZB124;G3,OPh,H,H,H] , [ZB125;G3,CF.sub.3,H,H,H] , [ZB1 26;G3,F,H,H,H] , [ZB127;G3,Cl,H,H,H] , [ZB228;G3,Br,H,H,H] , [ZB1 29;G3,CN,H,H,H] , [ZB130;G3,H,Me,H,H] , [ZB131;G3,H,Et,H,H] , [ ZB 132;G3,H,Pr,H,H] , [ZB133;G3,H,i-Pr,H,H] , [ZB134;G3,H,c-Pr,H,H] , [ZB135;G3,H,Ph,H,H] , [ZB136;G3,H,OMe,H,H] , [ZB137;G3, H,OEt,H,H] , [ZB138:G3,H,OPh,H,H] , [ZB139;G3,H,CF.sub.3,H,H] , [ZB140 ;G3,H,F,H,H] , [ZB141;G3,H,Cl,H,H] , [ZB142;G3,H,Br,H,H] , [ZB143 ;G3,H,CN,H,H] , [ZB144;G3,H,H,Me,H] , [ZB145;G3,H,H,Et,H] , [ZB14 6;G3,H,H,Pr,H] , [ZB147;G3,H,H,i-Pr,H] , [ZB148;G3,H,H,c-Pr,H] , [ZB149;G3,H,H,Ph,H] , [ZB150;G3,H,H,OMe,H] , [ZB151;G3,H, H,OEt,H] , [ZB152;G3,H,H,OPh,H] , [ZB153;G3,H,H,CF.sub.3,H] , [ZB154;G 3,H,H,F,H] , [ZB155;G3,H,H,Cl,H] , [ZB156;G3,H,H,Br,H] , [ZB157;G 3,H,H,eN,H] , [ZB158;G3,H,H,H,Me] , [ZB159;G3,H,H,H,Et] , [ZB160; G3,H,H,H,Pr] , [ZB161;G3,H,H,H,i-Pr] , [ZB162;G3,H,H,H,c-Pr] , [ZB163;G3,H,H,H,Ph] , [ZB164;G3,H,H,H,OMe] , [ZB165;G3,H,H, H,OEt] , [ZB166;G3,H,H,H,OPh] , [ZB167;G3,H,H,H,CF.sub.3] , [ZB168;G3, H,H,H,F] ,[ZB169;G3,H,H,H,Cl] , [ZB170;G3,H,H,H,Br] , [ZB171;G3, H,H,H,eN] , [ZB172;G4,H,H,H,-] , [ZB173;G4,Me,H,H,-] , [ZB174;G4, Et,H,H,-] , [ZB175;G4,Pr,H,H,-] , [ZB176;G4,i-Pr,H,H,-] , [ZB177;G4,c-Pr,H,H,-] , [ZB178;G4,Ph,H,H,-] , [ZB179;G4,OMe,H,H,-] , [ZB180;G 4,OEt,H,H,-] , [ZB181;G4,OPh,H,H,-] , [ZB182;G4,CF.sub.3,H,H,-] , [ZB1 83;G4,F,H,H,-] , [ZB184;G4,Cl,H,H,-] , [ZB185;G4,Br,H,H,-] , [ZB1 86;G4,CN,H,H,-] , [ZB187;G4,H,Me,H,-] , [ZB188;G4,H,Et,H,-] , [ZB 189;G4,H,Pr,H,-] , [ZB190;G4,H,i-Pr,H,-] , [ZB191;G4,H,c-Pr,H,-] , [ZB192;G4,H,Ph,H,-] , [ZB193;G4,H,OMe,H,-] , [ZB194;G4, H,OEt,H,-] , [ZB195;G4,H,OPh,H,-j , [ZB196;G4,H,CF.sub.3,H,-] , [ZB197 ;G4,H,F,H,-] , [ZB198:G4,H,C1,H,-] , [ZB199;G4,H,Br,H,-] , [ZB200 ;G4,H,CN,H,-],[ZB201;G4,H,H,Me,-],[ZB202;G4,H,H,Et,-],[ZB20 3;G4,H,H,Pr,-] , [ZB204;G4,H,H,i-Pr,-] , [ZB205;G4,H,H,c-Pr,-] , [ZB206;G4,H,H,Ph-] , [ZB207;G4,H,H,OMe,-] , [ZB208;G4,H, H,OEt,-] , [ZB209;G4,H,H,OPh,-] , [ZB210;G4,H,H,CF.sub.3-] , [ZB211;G 4,H,H,F,-] , [ZB212;G4,H,H,Cl,-] , [ZB213;G4,H,H,Br,-] , [ZB214;G 4,H,H,CN,-] , [ZB215;G5,H,H,H,-] , [ZB216;G5,Me,H,H,-] , [ZB217;G 5,Et,H,H,-] , [ZB218;G5,Pr,H,H,-] , [ZB219;G5,i-Pr,H,H,-] , [ZB220;G5,c-Pr,H,H,-] , [ZB221;G5,Ph,H,H,-] , [ZB222;G5,OMe,H,H,-] , [Z8223;G 5,OEt,H,H,-] , [ZB224;G5,OPh,H,H,-] , [ZB225;G5,CF.sub.3,H,H,-] , [ZB2 26;G5,F,H,H,-] , [ZB227;G5,Cl,H,H,-] , [ZB228;G5,Br,H,H,-] , [ZB2 29:G5,CN,H,H,-] , [ZB230;G5,H,Me,H,-] , [ZB231;G5,H,Et,H,-] , [ZB 232;G5,H,Pr,H,-] , [ZB233;G5,H,i-Pr,H,-] , [ZB234;G5,H,c-Pr,H,-] , [ZB235;G5,H,Ph,H,-] , [ZB236;G5,H,OMe,H,-] , [ZB237;G5, H,OEt,H,-] , [ZB238;G5,H,OPh,H,-] , [ZB239;G5,H,CF.sub.3,H,-] , [ZB240 ;G5,H,F,H,-],[ZB241;G5,H,Cl,H,-],[ZB242;G5,H,Br,H,-],[ZB243 ;G5,H,CN,H,-] , [ZB244;G5,H,H,Me,-] , [ZB245;G5,H,H,Et,-] , [ZB24 6;G5,H,I-i,Pr,-] , [ZB247;G5,H,H,i-Pr,-] , [ZB248;G5,H,H,c-Pr,-] , [ZB249;G5,H,H,Ph,-] , [ZB250;G5,H,H,OMe,-] , [ZB251;G5,H, H,OEt,-] , [ZB252;G5,H,H,OPh,-] , [ZB253;G5,H,H,CF.sub.3,-] , [ZB254;G 5,H,H,F,-] , [ZB255;G5,H,H,Cl,-] , [ZB256;G5,H,H,Br,-] , [ZB257;G 5,H,H,CN,-] , [ZB258;G6,H,H,H,-] , [ZB259;G6,Me,H,H,-] , [ZB260;G 6,Et,H,H,-] , [ZB261;G6,Pr,H,H,-] , [ZB262;G6,i-Pr,H,H,-] , [ZB263;G6,c-Pr,H,H,-] , [ZB254;G6,Ph,H,H,-] , [ZB265;G6,OMe,H,H,-] , [ZB266;G 6,OEt,H,H,-] , [ZB267;G6,OPh,H,H,-] , [ZB268;G6,CF.sub.3,H,H,-] , [ZB2 69;G6,F,H,H,-] , [ZB270;G6,Cl,H,H,-] , [ZB271;G6,Br,H,H,-] , [ZB2 72;G6,CN,H,H,-],[ZB273;G6,H,Me,H,-],[ZB274;G6,H,Et,H,-],[ZB 275;G6,H,Pr,H,-] , [ZB276;G6,H,i-Pr,H,-] , [ZB277;G6,H,c-Pr,H,-] , [ZB278;G6,H,Ph,H,-] , [ZB279:G6,H,OMe,H,-] , [ZB280;G6, H,OEt,H,-] , [ZB281;G6,H,OPh,H,-] , [ZB282;G6,H,CF.sub.3,H,-] , [ZB283 ;G6,H,F,H,-] , [ZB284;G6,H,Cl,H,-] , [ZB285;G6,H,Br,H,-] , [ZB286 ;G6,H,CN,H,-] , [ZB287;G6,H,H,Me,-] , [ZB288;G6,H,H,Et,-] , [ZB28 9;G6,H,H,Pr,-] , [ZB290;G6,H,H,i-Pr,-] , [ZB291;G6,H,H,c-Pr,-] , [ZB292;G6,H,H,Ph,-] , [ZB293;G6,H,H,OMe,-] , [ZB294;G6,H, H,OEt,-] , [ZB295;G6,H,H,OPh,-] , [ZB296;G6,H,H,CF.sub.3,-] , [ZB297;G 6,H,H,F,-] , [ZB298;G6,H,H,Cl,-] , [ZB299;G6,H,H,Br,-] , [ZB300;G 6,H,H,CN,-] , [ZB301;G7,H,H,H,-] , [ZB302;G7,Me,H,H,-] , [ZB303;G 7,Et,H,H,-] , [ZB304;G7,Pr,H,H,-] , [ZB3G5;G7,i-Pr,H,H,-] , [ZB306;G7,c-Pr,H,H,-] , [ZB307;C7,Ph,H,H,-] , [ZB308;G7,OMe,H,H,-] , [ZB309;G 7,OEt,H,H,-] , [ZB310;G7,OPh,H,H,-] , [ZB311;G7,CF.sub.3,H,H,-] , [ZB3 12;G7,F,H,H,-] , [ZB313;G7,Cl,H,H,-] , [ZB314;G7,Br,H,H,-] , [ZB3 15;G7,CN,H,H,-],[ZB316;G7,H,Me,H,-],[ZB317;G7,H,Et,H,-],[ZB 318;G7,H,Pr,H,-] , [ZB319;G7,H,i-Pr,H,-] , [ZB320;G7,H,c-Pr,H,-] , [ZB321;G7,H,Ph,H,-] , [ZB322;G7,H,OMe,H,-] , [ZB323;G7, H,OEt,H,-] , [ZB324;G7,H,OPh,H,-] , [ZB325;G7,H,CF.sub.3,H,-] , [ZB326 ;G7,H,F,H,-] , [ZB327;G7,H,Cl,H,-] , [ZB328;G7,H,Br,H,-] , [ZB329 ;G7,H,CN,H,-] , [ZB330;G7,H,H,Me,-] , [ZB331;G7,H,H,Et-] , [ZB33 2;G7,H,H,Pr,-] , [ZB333;G7,H,H,i-Pr,-] , [ZB334;G7,H,H,c-Pr,-] , [ZB335;G7,H,H,Ph,-] , [ZB336;G7,H,H,OMe,-] , [ZB337;G7,H, H,OEt,-] , [ZB338;G7,H,H,OPh,-] , [ZB339;G7,H,H,CF.sub.3,-] , [ZB340;G 7,H,H,F,-] , [ZB341;G7,H,H,Cl,-] , [ZB342;G7,H,H,Br,-] , [ZB343;G 7,H,H,CN,-] , [ZB344;G8,H,H,H,-] , [ZB345;G8,Me,H,H,-] , [ZB346;G 8,Et,H,H,-] , [ZB347;G8,Pr,H,H,-] , [ZB348;G8,i-Pr,H,H,-] , [ZB349;G8,c-Pr,H,H,-],[ZB350;G8,Ph,H,H,-] , [ZB351;G8,OMe,H,H,-] , [ZB352;G 8,OEt,H,H,-] , [ZB353;G8,OPh,H,H,-] , [ZB354;G8,CF.sub.3,H,H,-] , [ZB3 55;G8,F,H,H,-] , [ZB356;G8,Cl,H,H,-] , [ZB357;G8,Br,H,H,-] , [ZB3 58;G8,CN,H,H,-] , [ZB359;G8,H,Me,H,-] , [ZB360;G8,H,Et,H,-] , (ZB 361;G8,H,Pr,H,-] , [ZB362;G8,H,i-Pr,H,-] , [ZB363;G8,H,c-Pr,H,-], [ZB364;G8,H,Ph,H,-], [ZB365;G8,H,OMe,H,-], [ZB366;G8, H,OEt,H,-] , [ZB367;G8,H,OPh,H,-] , [ZB368;G8,H,CF.sub.3,H,-] , [ZB369 ;G8,H,F,H,-] , [ZB370;G8,H,Cl,H,-] , [ZB371;G8,H,Br,H,-] , [ZB372 ;G8,H,CN,H,-] , [ZB373;G8,H,H,Me,-] , [ZB374;G8,H,H,Et,-] , [ZB37 5;G8,H,H,Pr′,-] , [ZB376;G8,H,H,1-Pr,-] , [ZB377;G8,H,H,c-Pr,-] , [ZB378;G8,H,H,Ph,-] , [ZB379;G8,H,H,OMe,-] , [ZB380;G8,H, H,OEt,-] , [ZB382;G8,H,H,OPh,-] , [ZB382;G8,H,H,CF.sub.3.-] , [ZB383;G 8,H,H,F,-] , [ZB384;G8,H,H,Cl,-] , [ZB385;G8,H,H,Br,-] , [ZB386;G 8,H,H,CN,-] , [ZB387;G9,H,H,H,-] , [ZB388;G9,Me,H,H,-] , [ZB389;G 9,Et,H,H,-] , [ZB390;G9,Pr,H,H,-] , [ZB391;G9,i-Pr,H,H,-] , [ZB392;G9,c-Pr,H,H,-] , [ZB393;G9,Ph,H,H,-] , [ZB394;G9,OMe,H,H,-] , [ZB395;G 9,OEt,H,H,-] , [ZB396;G9,OPh,H,H,-] , [ZB397;G9,CF.sub.3,H,H,-] , [ZB3 98;G9,F,H,H,-] , [ZB399;G9,Cl,H,H,-] , [ZB400;G9,Br,H,H,-] , [ZB4 01;G9,CN,H,H,-] , [ZB402;G9,H,Me,H,-] , [ZB403;G9,H,Et,H,-] , [ZB 404;G9,H,Pr,H,-] , [ZB405;G9,H,i-Pr,H,-] , [ZB406;G9,H,c-Pr,H,-] , [ZB407;G9,H,Ph,H,-] , [ZB408;G9,H,OMe,H,-] , [ZB409;G9, H,OEt,H,-] , [ZB410;G9,H,OPh,H,-] , [ZB411;G9,H,CF.sub.3,H, -] , [ZB412 ;G9,H,F,H,-] , [ZB413;G9,H,Cl,H,-] , [ZB414;G9,H,Br,H,-] , [ZB415 ;G9,H,CN,H,-] , [ZB416;G9,H,H,Me,-] , [ZB417;G9,H,H,Et,-] , [ZB41 8;G9,H,H,Pr,-] , [ZB419;G9,H,H,i-Pr,-] , [ZB420;G9,H,H,c-Pr,-] , [ZB421;G9,H,H,Ph,-] , [ZB422;G9,H,H,OMe,-] , [ZB423;G9,H, H,OEt,-] , [ZB424;G9,H,H,OPh,-] , [ZB425;G9,H,H,CF.sub.3,-] , [ZB426;G 9,H,H,F,-] , [ZB427;G9,H,H,Cl,-] , [ZB428;G9,H,H,Br,-] , [ZB429;G 9,H,H,CN,-] , [ZB430;G10,H,H,H,-] , [ZB431;G10,Me,H,H,-] , [ZB432 ;G10,Et,H,H,-] , [ZB433;G10,Pr,H,H,-] , [ZB434;G10,i-Pr,H,H,-] , [ZB435;G10,c-Pr,H,H,-] , [ZB436;G10,Ph,H,H,-] , [ZB437;G10,OMe,H,H,-], [ZB438 ;G10,OEt,H,H,-] , [ZB439;G10,OPh,H,H,-] , [ZB440;G10,CF.sub.3,H,H,-] , [ZB441;G10,F,H,H,-] , [ZB442;G10,Cl,H,H,-] , [ZB443;G10,Br,H,H ,-] , [ZB444;G10,CN,H,H,-] , [ZB445;G10,H,Me,H,-] , [ZB446;G10,H, Et,H,-] , [ZB447;G10,H,Pr,H,-] , [ZB448;G10,H,i-Pr,H,-] , [ZB449;G10,H,c-Pr,H,-] , [ZB450;G10,H,Ph,H,-] , [ZB451;G10,H,OMe,H,-] , [ZB452;G 10,H,OEt,H,-] , [ZB453;G10,H,OPh,H,-] , [ZB454;G10,H,CF.sub.3,H,-] , [ ZB455;G10,H,F,H,-] , [ZB456;G10,H,Cl,H,-) , [ZB457;G10,H,Br,H,-] , [ZB458;G10,H,CN,H,-] , [ZB459;G10,H,H,Me,-] , [ZB46C;G10,H,H, Et,-] , [ZB461;G10,H,H,Pr,-] , [ZB462;G10,H,H,i-Pr,-] , [ZB463;G10,H,H,c-Pr,-] , [ZB464;G10,H,H,Ph,-] , [ZB465;G10,H,H,OMe,-] , [ZB466;G10 ,H,H,OEt,-] , [ZB467;G10,H,H,OPh,-] , [ZB468;G10,H,H,CF.sub.3,-] , [ZB 469;G10,H,H,F,-] , [ZB470;G10,H,H,Cl,-] , [ZB471;G10,H,H,Br,-] , [ZB472;G10,H,H,CN,-] , [ZB473;G11,H,H,H,-] , [ZB474;G11,H,Me,H, -] , [2B475;G11,H,Et,H,-] , [ZB476;G11,H,Pr,H,-] , [ZB477;G11,H,i-Pr,H,-] , [ZB478;G11,H,c-Pr,H,-] , [ZB479;G11,H,Ph,H,-] , [ZB480;G11,H,OMe,H,-] , [ZB481;G 11,H,OEt,H,-] , [ZB482;G11,H,OPh,H,-] , [ZB483;G11,H,CF.sub.3,H,-] , [ ZB484;G11,HF,H,-] , [ZB485;G11,H,Cl,H,-] , [ZB486;G11,H,Br,H,-] , [ZB487;G11,H,CN,H,-] , [ZB488;G11,H,H,Me,-] , [ZB489;G11,H,H,E t,-] , [ZB490;G11,H,H,Pr,-] , [ZB491;G11,H,H,i-Pr,-] , [ZB492;G11,H,H,c-Pr,-] , [ZB493;G11,H,H,Ph,-] , [ZB494;G11,H,H,OMe,-] , [ZB495;G11 ,H,H,OEt,-] , [ZB496;G11,H,H,OPh,-] , [ZB497;G11,H,H,CF.sub.3,-] , [ZB 498;G11,H,H,F,-] , [ZB499;G11,H,H,C1,-] , [ZB500;G11,H,H,Br,-] , [ZB501;G11,H,H,CN,-] , [ZB502;G11,Me,H,H,-] , [ZB503;G11,Me,Me, H,-] , [ZB504;G11,Me,Et,H,-] , [ZB505;G11,Me,Pr,H,-] , [ZB506;G11 ,Me,i-Pr,H,-] , [ZB507;G11,Me,c-Pr,H,-] , [ZB508;G11,Me,Ph,H,-] , [ZB509;G11,Me,OMe,H,-] , [ZB510 ;G11,Me,OEt,H,-] , [ZB511;G11,Me,OPh,H,-] , [ZB512;G11,Me,CF.sub.3,H ,-] , [ZB513;G11,Me,F,H,-] , [ZB514;G11,Me,Cl,H,-] , [ZB515;G11,M e,Br,H,-] , [ZB516;G11,Me,CN,H,-] , [ZB517;G11,Me,H,Me,-] , [ZB51 8;G11,Me,H,Et,-] , [ZB519;G11,Me,H,Pr,-] , [ZB520;G11,Me,H,i-Pr,-] , [ZB521;G11,Me,H,c-Pr,-] , [ZB522;G11,Me,H,Ph,-] , [ZB523;G11,Me,H,OMe,-] , [ZB524;G 11,Me,H,OEt,-] , [ZB525;G11,Me,H,OPh,-] , [ZB526;G11,Me,H,CF.sub.3,-] , [ZB527;G11,Me,H,F,-] , [ZB528;G11, Me,H,Cl,-] , [ZB529;G11,Me, H,Br,-] , [ZB530;G11,Me,H,CN,-] , [ZB531;G12,H,H,H,-] , [ZB532;G1 2,Me,H,H,-] , [ZB533;G12,Et,H,H,-] , [ZB534;G12,Pr,H,H,-] , [ZB53 5;G12,i-Pr,H,H,-] , [ZB536;G12,c-Pr,H,H,-] , [ZB537;G12,Ph,H,H,-] , [ZB538;G12,OMe,H,H,-] , [ZB539 ;G12,OEt,H,H,-] , [ZB540;G12,OPh,H,H,-] , [ZB541;G12,CF.sub.3,H,H,-] , [ZB542;G12,F,H,H,-] , [ZB543;G12,Cl,H,H,-] , [ZB544;G12,Br,H,H ,-] , [ZB545;G12,CN,H,H,-] , [ZB546;G12,H,Me,H,-] , [ZB547;G12,H, Et,H,-] , [ZB548;G12,H,Pr,H,-] , [ZB549;G12,H,i-Pr,H,-] , [ZB550;G12,H,c-Pr,H,-] , [ZB551;G12,H,Ph,H,-] , [ZB552;G12,H,OMe,H,-] , [ZB553;G 12,H,OEt,H,-] , [ZB554;G12,H,OPh,H,-] , [ZB555;G12,H,CF.sub.3,H,-] , [ ZB556;G12,H,F,H,-] , [ZB557;G12,H,Cl,H,-] , [ZB558;G12,H,Br,H,-] , [ZB559;G12,H,CN,H,-] , [ZB560;G12,H,H,Me,-] , [ZB561;G12,H,H, Et,-] , [ZB562;G12,H,H,Pr,-] , [ZB563;G12,H,H,i-Pr,-] , [ZB564;G12,H,H,c-Pr,-] , [ZB565;G12,H,H,Ph,-] , [ZB566;G12,H,H,OMe,-] , [ZB567;G12 ,H,H,OEt,-] , [ZB568;G12,H,H,OPh,-] , [ZB569;G12,H,H,CF.sub.3,-] , [ZB 570;G12,H,H,F,-] , [ZB571;G12,H,H,C1,-] , [ZB572;G12,H,H,Br,-] , [ZB573;G12,H,H,CN,-] , [ZB574;G13,H,H,H,-] , [ZB575;G13,Me,H,H, -] , [ZB576;G13,Et,H,H,-] , [ZB577;G13,Pr,H,H,-] , [ZB578;G13,i-Pr,H,H,-] , [ZB579;G13,c-Pr,H,H,-] , [ZB580;G13,Ph,H,H,-] , [ZB581;G13,OMe,H,H,-] , [ZB582 ;G13,OEt,H,H,-] , [ZB583;G13,OPh,H,H,-] , [ZB584;G13,CF3,H,H,-] , [ZB585;G13,F,H,H,-] , [ZB586;G13,Cl,H,H,-] , [ZB587;G13,Br,H,H ,-] , [ZB588;G13,CN,H,H,-] , [ZB589;G13,H,H,Me,-] , [ZB590;G13,H, H , Et , -] , [ZB591 ; G13 , H , H , Pr , -] , [ZB592 ; G13 , H , H , i-Pr , -] , [ZB593 ; G13 , H , H , c-Pr , -] , [ZB594 ; G13 , H , H , Ph , -] , [ZB595 ; G13 , H , H , OMe , -] , [ZB596 ; G13 , H , H , OEt , -] , [ZB597 ; G13 , H , H , OPh , -] , [ZB598 ; G13 , H , H , CF.sub.3 , -] , [ZB 599 ; G13 , H , H , F , -] , [ZB600 ; G13 , H , H , Cl , -] , [ZB601 ; G13 , H , H , Br , -] , [ZB602 ; G13 , H , H , CN , -] , [ZB603 ; G13 , H , Me , H , -] , [ZB604 ; G13 , Me , Me , H , -] , [ZB605 ; G13 , Et , Me , H , -] , [ZB606 ; G13 , Pr , Me , H , -] , [ZB607 ; G13 , i-Pr , Me , H , -] , [ZB608 ; G13 , c-Pr , Me , H , -] , [ZB609 ; G13 , Ph , Me , H , -] , [ZB610 ; G13 , OMe , Me , H , -] , [ZB 611 ; G13 , OEt , Me , H , -] , [ZB612 ; G13 , OPh , Me , H , -] , [ZB613 ; G13 , CF.sub.3 , M e , H , -] , [ZB614 ; G13 , F , Me , H , -] , [ZB615 ; G13 , Cl , Me , H , -] , [ZB616 ; G1 3 , Br , Me , H , -] , [ZB617 ; G13 , CN , Me , H , -] , [ZB618 ; G13 , H , Me , Me , -] , [Z B619 ; G13 , H , Me , Et , -] , [ZB620 ; G13 , H , Me , Pr , -] , [ZB621 ; G13 , H , Me , i -Pr , -] , [ZB622 ; G13 , H , Me , c-Pr , -] , [ZB623 ; G13 , H , Me , Ph , -] , [ZB624 ; G13 , H , Me , OMe , -] , [ZB625 ; G 13 , H , Me , OEt , -] , [ZB626 ; G13 , H , Me , OPh , -] , [ZB627 ; G13 , H , Me , CF.sub.3 , -] , [ZB628 ; G13 , H , Me , F , -] , [ZB629 ; G13 , H , Me , Cl , -] , [ZB630 ; G13 , H , M e , Br , -] , [ZB631 ; G13 , H , Me , CN , -] , [ZB632 ; G14 , H , H , H , -] , [ZB633 ; G1 4 , Me , H , H , -] , [ZB634 ; G14 , Et , H , H , -] , [ZB635 ; G14 , Pr , H , H , -] , [ZB63 6 ; G14 , i-Pr , H , H , -] , [ZB637 ; G14 , c-Pr , H , H , -] , [ZB638 ; G14 , Ph , H , H , -] , [ZB639 ; G14 , OMe , H , H , -] , [ZB640 ; G14 , OEt , H , H , -] , [ZB641 ; G14 , OPh , H, H , -] , [ZB642 ; G14 , CF.sub.3 , H , H , -] , [ZB643 ; G14 , F, H , H , -] , [ZB644 ; G14 , Cl , H , H, -] , [ZB645 ; G14 , Br , H , H , -] , [ZB646 ; G14 , CN , H , H , -] , [ZB647 ; G14 , H , Me , H , -] , [ZB648 ; G14 , H , Et , H , -] , [ZB649 ; G14 , H , Pr , H , -] , [ZB650 ; G14 , H , i-Pr , H , -] , [ZB651 ; G14 , H , c-Pr , H , -] , [ZB652 ; G14 , H , Ph , H , -] , [ZB653 ; G14 , H , OMe , H , -] , [ZB654 ; G 14 , H , OEt , H , -] , [ZB655 ; G14 , H , OPh , H , -] , [ZB656 ; G14 , H , CF.sub.3 , H , -] , [ ZB657 ; G14 , H , F , H , -] , [ZB658 ; G14 , H, Cl , H , -] , [ZB659 ; G14 , H , Br , H , -] , [ZB660 ; G14 , H , CN , H , -] , [ZB661 ; G14 , H , H , Me , -] , [ZB662 ; G14 , H , H , Et , -] , [ZB663 ; G14 , H , H , Pr , -] , [ZB664 ; G14 , H , H , i-Pr , -] , [ZB665 ; G14 , H , H , c-Pr , -] , [ZB666 ; G14 , H , H , Ph , -] , [ZB667 ; G14 , H , H , OMe , -] , [ZB668 ; G14 , H , H , OEt , -] , [ZB669 ; G14 , H , H , OPh , -] , [ZB670 ; G14 , H , H , CF.sub.3 , -] , [ZB 671 ; G14 , H , H , F , -] , [ZB672 ; G14 , H , H , Cl , -] , [ZB673 ; G14 , H , H , Br , -] , [ZB674 ; G14 , H , H , CN , -] , [ZB675 ; G15 , H , H , H , -] , [ZB676 ; G15 , Me , H , H , -] , [ZB677 ; G15 , Et , H , H , -] , [ZB678 ; G15 , Pr , H , H , -] , [ZB679 ; G15 , i-Pr , H , H , -] , [ZB680 ; G15 , c-Pr , H , H , -] , [ZB681 ; G15 , Ph , H , H , -] , [ZB682 ; G15 , OMe , H , H, -] , [ZB683 ; G15 , OEt , H , H , -] , [ZB684 ; G15 , OPh , H , H , -] , [ZB685 ; G15 , CF.sub.3 , H , H , -] , [ZB686 ; G15 , F , H , H , -] , [ZB687 ; G15 , Cl , H , H , -] , [ZB688 ; G15 , Br , H , H , -] , [ZB689 ; G15 , CN , H , H , -] , [ZB690 ; G15 , H , Me , H , -] , [ZB691 ; G15 , H , Et , H , -] , [ZB692 ; G15 , H , Pr , H , -] , [ZB693 ; G15 , H , i-Pr , H , -] , [ZB694 ; G15 , H , c-Pr , H , -] , [ZB695 ; G15 , H , Ph , H , -] , [ZB696 ; G15 , H , OMe , H , -] , [ZB697 ; G 15 , H , OEt , H , -] , [ZB698 ; G15 , H , OPh , H , -] , [ZB699 ; G15 , H , CF.sub.3 , H , -] , [ ZB700 ; G15 , H , F , H , -] , [ZB701 ; G15 , H , Cl , H , -] , [ZB702 ; G15 , H , Br , H , -] , [ZB703 ; G15 , H , CN , H , -] , [ZB704 ; G15 , H , H , Me , -] , [ZB705 ; G15 , H , H , Et , -] , [ZB706 ; G15 , H , H , Pr , -] , [ZB707 ; G15 , H , H , i-Pr , -] , [ZB708 ; G15 , H, H , c-Pr , -] , [ZB709 ; G15 , H , H , Ph , -] , [ZB710 ; G15 , H , H , OMe , -] , [ZB711 ; G15 , H , H , OEt , -] , [ZB712 ; G15 , H , H , OPh , -] , [ZB713 ; G15 , H , H , CF.sub.3 , -] , [ZB 714 ; G15 , H , H , F , -] , [ZB715 ; G15 , H, H , Cl , -] , [ZB716 ; G15 , H, H , Br , -] , [ZB717 ; G15 , H , H, CN , -] , [ZB718 ; G16 , H , H , - , -] , [ZB719 ; G16 , Me , H , - , -] , [ZB720 ; G16 , Et , H , - , - ] , [ZB721 ; G16 , Pr , H , - , -] , [ZB722 ; G16 , i-Pr , H , - , -] , [ZB723 ; G16 , c-Pr , H , - , -] , [ZB724 ; G16 , Ph ,H , - , -] , [ZB725 ; G16 , OMe , H , - , -] , [ZB726 ; G16 , OEt , H , - , -] , [ZB727 ; G16 , OPh , H , - , -] , [ZB728 ; G16 , CF.sub.3 , H , - , -] , [ZB729 ; G16 , F , H , - , -] , [ZB730 ; G16 , Cl , H , - , -] , [ZB731 ; G16 , Br , H , -, -] , [ZB732 ; G16 , CN , H, - , -] , [ZB733 ; G16 , H , Me , - , -] , [ZB734 ; G16 , H , Et , - , -] , [ZB735 ; G16 , H , Pr , - , -] , [ZB736 ; G16 , H , i-Pr , - , -] , [ZB737 ; G16 , H , c-Pr , - , -] , [ZB738 ; G16 , H , Ph , - , -] , [ZB739 ; G16 , H , OMe , - , -] , [ZB740 ; G 16 , H , OEt , - , -] , [ZB741 ; G16 , H , OPh , - , -] , [ZB742 ; G16 , H , CF.sub.3 , - , -] , [ ZB743 ; G16 , H , F , - , -] , [ZB744 ; G16 , H , Cl , - , -] , [ZB745 ; G16 , H , Br , - , -] , [ZB746 ; G16 , H , CN , - , -] , [ZB747 ; G17 , H , H , - , -] , [ZB748 ; G17 , Me, H , - , -] , [ZB749 ; G17 , Et , H , - , -] , [ZB750 ; G17 , Pr , H , - , -] , [ZB751 ; G17 , i -Pr , H , - , -] , [ZB752 ; G17 , c-Pr , H , - , -] , [ZB753 ; G17 , Ph , H , - , -] , [ZB754 ; G17 , OMe , H , - , -] , [ZB755 ; G17 , OEt , H , - , -] , [ZB756 ; G17 , OPh , H , - , -] , [ZB757 ; G17 , CF.sub.3 , H , - , - ] , [ZB758 ; G17 , F , H , -] , [ZB759 ; G17 , Cl , H , - , -] , [ZB760 ; G17 , Br , H , -, -] , [ZB761 ; G17 , CN , H , - , -] , [ZB762 ; G17 , H , Me , - , -] , [ZB763 ; G17 , H , Et , - , -] , [ZB764 ; G17 , H , Pr , - , -] , [ZB765 ; G17 , H , i-Pr , - , -] , [ZB766 ; G17 , H , c-Pr , - , - ] , [ZB767 ; G17 , H, Ph , - , -] , [ZB768 ; G17 , H , OMe , - , -] , [ZB769 ; G 17 , H , OEt , - , -] , [ZB770 ; G17 , H , OPh , - , -] , [ZB771 ; G17 , H , CF.sub.3 , - , -] , [ ZB772 ; G17 , H , F , - , -] , [ZB773 ; G17 , H , Cl , - , -] , [ZB774 ; G17 , H , Br , - , -] , [ZB775 ; G17 , H , CN , - , -] , [ZB776 ; G18 , H , H , - , -] , [ZB777 ; G18 , Me , H , - , -] , [ZB778 ; G18 , Et , H , - , -] , [ZB779 ; G18 , Pr , H , - , -] , [ZB780 ; G18 , i -Pr , H, - , -] , [ZB781 ; G18 , c-Pr , H , - , -] , [ZB782 ; G18 , Ph , H , - , -] , [ZB783 ; G18 , OMe , H , - , -] , [ZB784 ; G18 , OEt , H , - , -] , [ZB785 ; G18 , OPh , H , - , -] , [ZB786 ; G18 , CF.sub.3 , H , - , -] , [ZB787 ; G18 , F , H , - , -] , [ZB788 ; G18 , Cl , H , - , -] , [ZB789 ; G18 , Br , H , -, -] , [ZB790 ; G18 , CN , H , - , -] , [ZB791 ; G18 , H , Me , - , -] , [ZB792 ; G18 , H , Et , - , - ] , [ZB793 ; G18 , H , Pr , - , -] , [ZB794 ; G18 , H, i-Pr , - , -] , [ZB795 ; G18 , H , c-Pr , - , -] , [ZB796 ; G18 , H , Ph , - , -] , [ZB797 ; G18 ,H , OMe , - , -] , [ZB798 ; G 18 , H ,OEt , - , -] , [ZB799 ; G18 , H , OPh , - , -] , [ZB800 ; G18 , H, CF.sub.3, - , -] , [ ZB801 ; G18 , H , F , - , -] , [ZB802 ; G18 , H , Cl , - , -] , [ZB803 ; G18 , H , Br , -] , [ZB804 ; G18 , H , CN , - , -] , [ZB805 ; G19 , H , H , - , -] , [ZB806 ; G19 , Me , H , - , -] , [ZB807 ; G19 , Et , H , - , -] , [ZB808 ; G19 , Pr , H , - , -] , [ZB809 ; G19, i -Pr , H , - , -] , [ZB810 ; G19 , c-Pr , H , - , -] , [ZB811 ; G19 , Ph , H , - , -] , [ZB812 ; G19 , OMe , H , - , -] , [ZB813 ; G19 , OEt , H , - , -] , [ZB814 ; G19 , OPh , H, - , -] , [ZB815 ; G19 , CF.sub.3 , H , - , -] , [ZB816 ; G19 , F , H , - , -] , [ZB817 ; G19 , Cl , H , - , -] , [ZB818 ; G19 , Br , H , -, -] , [ZB819 ; G19 , CN , H , - , -] , [ZB820 ; G19 , H , Me , - , -] , [ZB821 ; G19 , H , Et , - , -] , [ZB822 ; G19 , H , Pr , - , -] , [ZB823 ; G19 , H , i-Pr , - , -] , [ZB824 ; G19 , H , c-Pr , - , -] , [ZB825 ; G19 , H , Ph , - , -] , [ZB826 ; G19 , H , OMe , - , -] , [ZB827 ; G 19 , H , OEt , - , -] , [ZB828 ; G19 , H , OPh , - , -] , [ZB829 ; G19 , H, CF.sub.3 , - , -] , [ ZB830 ; G19 , H , F , - , -] , [ZB831 ; G19 , H , Cl , - , -] , [ZB832 ; G19 , H , Br , - , -] , [ZB833 ; G19 , H , CN , - , -] , [ZB834 ; G20 , H , H , - , -] , [ZB835 ; G20 , Me , H , - , -] , [ZB836 ; G20 , Et , H , - , -] , [ZB837 ; G20 , Pr , H , - , -] , [ZB838 ; G20 , i -Pr , H , - , -] , [ZB839 ; G20 , c-Pr , H , - , -] , [ZB840 ; G20 , Ph , H , - , -] , [ZB841 ; G20 , OMe , H , - , -] , [ZB842 ; G20 , OEt , H, - , -] , [ZB843 ; G20 , OPh , H , - , -] , [ZB844 ; G20 , CF.sub.3 , H , - , -] , [ZB845 ; G20 , F , H , - , -] , [ZB846 ; G20 , Cl , H , - , -] , [ZB847 ; G20 , Br , H , -, -] , [ZB848 ; G20 , CN , H , - , -] , [ZB849 ; G20 , H , Me , - , -] , [ZB850 ; G20 , H , Et , - , -] , [ZB851 ; G20 , H , Pr , - , -] , [ZB852 ; G20 , H , i-Pr , - , -] , [ZB853 ; G20 , H , c-Pr , - , -] , [ZB854 ; G20 , H , Ph , - , -] , [ZB855 ; G20 , H , OMe , - , -] , [ZB856 ; G 20 , H , OEt , - , -] , [ZB857 ; G20 , H , OPh , - , -] , [ZB858 ; G20 , H , CF.sub.3, - , -] , [ ZB859 ; G20 , H , F , - , -] , [ZB860 ; G20 , H , Cl , - , -] , [ZB861 ; G20 , H , Br , - , -] , [ZB862 ; G20 , H , CN , - , -] , [ZB863 ; G21 , H , H , - , -] , [ZB864 ; G21 , Me , H , - , -] , [ZB865 ; G21 , Et , H , - , -] , [ZB866 ; G21 , Pr , H , - , -] , [ZB867 ; G21 , i -Pr , H, - , -] , [ZB868 ; G21 , c-Pr , H , - , -] , [ZB869 ; G21 , Ph , H , - , -] , [ZB870 ; G21 , OMe , H , - , -] , [ZB871 ; G21 , OEt , H , - , -] , [ZB872 ; G21 , OPh , H ,- , -] , [ZB873 ; G21 , CF.sub.3 , H , - , -] , [ZB874 ; G21 , F , H , - , -] , [ZB875 ; G21 , Cl , H , - , -] , [ZB876 ; G21 , Br , H , -, -] , [ZB877 ; G21 , CN , H , - , -] , [ZB878 ; G21 , H , Me , - , -] , [ZB879 ; G21 , H , Et , - , -] , [ZB880 ; G21 , H , Pr , - , -] , [ZB881 ; G21 , H , i-Pr , - , -] , [ZB882 ; G21 , H , c-Pr , - , -] , [ZB883 ; G21 , H , Ph , - , -] , [ZB884 ; G21 , H , OMe , - , -] , [ZB885 ; G 21 , H , OEt , - , -] , [ZB886 ; G21 , H , OPh , - , -] , [ZB887 ; G21 , H , CF.sub.3 , - , -] , [ ZB888 ; G21 , H , F , - , -] , [ZB889 ; G21 , H , Cl , - , -] , [ZB890 ; G21 , H , Br , - , -] , [ZB891 ; G21 , H , CN , - , -] , [ZB892 ; G22 , H , H , - , -] , [ZB893 ; G22 , Me , H , - , -] , [ZB894 ; G22 , Et , H , - , -] , [ZB895 ; G22 , Pr , H, - , -] , [ZB896 ; G22 , i -Pr , H , - , -] , [ZB897 ; G22 , c-Pr , H , - , -] , [ZB898 ; G22 , Ph , H, - , -] , [ZB899 ; G22 , OMe , H , - , -] , [ZB900 ; G22 , OEt , H , - , -] , [ZB901 ; G22 , OPh , H , - , -] , [ZB902 ; G22 , CF.sub.3 , H , - , -] , [ZB903 ; G22 , F , H , - , -] , [ZB904 ; G22 , Cl , H , - , -] , [ZB905 ; G22 , Br , H , -, -] , [ZB906 ; G22 , CN , H , - , -] , [ZB907 ; G22 , H , Me , - , -] , [ZB908 ; G22 , H , Et , - , -] , [ZB909 ; G22 , H , Pr , - , -] , [ZB910 ; G22 , H , i-Pr , - , -] , [ZB911 ; G22 , H , c-Pr , - , -] , [ZB912 ; G22 , H , Ph , - , - ] , [ZB913 ; G22 , H , OMe , - , -] , [ZB914 ; G 22 , H , OEt , - , -] , [ZB915 ; G22 , H , OPh , - , -] , [ZB916 ; G22 , H , CF.sub.3 , - , -] , [ ZB917 ; G22 , H , F , - , -] , [ZB918 ; G22 , H , Cl , - , -] , [ZB919 ; G22 , H , Br , - , -] , [ZB920 ; G22 , H , CN , - , -] , [ZB921 ; G23 , H , H , - , -] , [ZB922 ; G23 , Me , H , - , -] , [ZB923 ; G23 , Et , H , - , -] , [ZB924 ; G23 , Pr , H , - , -] , [ZB925 ; G23 , i -Pr , H , - , -] , [ZB926 ; G23 , c-Pr , H , - , -] , [ZB927 ; G23 , Ph , H , - , -] , [ZB928 ; G23 , OMe , H , - , -] , [ZB929 ; G23 , OEt , H , - , -] , [ZB930 ; G23 , OPh , H , - , -] , [ZB931 ; G23 , CF.sub.3 , H , - , -] , [ZB932 ; G23 , F , H , - , -] , [ZB933 ; G23 , Cl , H , - , -] , [ZB934 ; G23 , Br , H , -, -] , [ZB935 ; G23 , CN , H , - , -] , [ZB936 ; G23 , H , Me , - , -] , [ZB937 ; G23 , H , Et , - , -] , [ZB938 ; G23 , H, Pr , - , -] , [ZB939 ; G23 , H , i-Pr , - , -] , [ZB940 ; G23 , H , c-Pr , - , -] , [ZB941 ; G23 , H , Ph , - , -] , [ZB942 ; G23 , H , OMe , - , -] , [ZB943 ; G 23 , H , OEt , - , -] , [ZB944 ; G23 , H , OPh , - , -] , [ZB945 ; G23 , H , CF.sub.3 , - , -] , [ ZB946 ; G23 , H , F , - , -] , [ZB947 ; G23 , H , Cl , - , -] , [ZB948 ; G23 , H , Br , - , -] , [ZB949 ; G23 , H , CN , - , -] , [ZB950 ; G24 , H , H , - , -] , [ZB951 ; G24 , Me , H , - , -] , [ZB952 ; G24 , Et , H , - , -] , [ZB953 ; G24 , Pr , H , - , -] , [ZB954 ; G24 , i -Pr , H , - , -], [ZB955 ; G24 , c-Pr , H , - , -] , [ZB956 ; G24 , Ph , H , - , -] , [ZB957 ; G24 , OMe , H , - , -] , [ZB958 ; G24 , OEt , H , - , -] , [ZB959 ; G24 , OPh , H , - , -] , [ZB960 ; G24 , CF.sub.3 , H , - , -] , [ZB961 ; G24 , F , H , - , -] , [ZB962 ; G24 , Cl , H , - , -] , [ZB963 ; G24 , Br , H , -, -] , [ZB964 ; G24 , CN , H , - , -] , [ZB965 ; G24 , H , Me , - , -] , [ZB966 ; G24 , H , Et , - , -] , [ZB967 ; G24 , H , Pr , - , -] , [ZB968 ; G24 , H , i-Pr , - , -] , [ZB970 ; G24 , H , Ph , - , -] , [ZB971 ; G24 , H , OMe , - , -] , [ZB972 ; G 24 , H , OEt , - , -] , [ZB973 ; G24 , H , OPh , - , -] , [ZB974 ; G24 , H , CF.sub.3 , - , -] , [ ZB975 ; G24 , H , F , - , -] , [ZB976 ; G24 , H , Cl , - , -] , [ZB977 ; G24 , H , Br , - , -] , [ZB978 ; G24 , H , CN , - , -] , [ZB979 ; G25 , H , H , H , -] , [ZB980 ; G25 , H , Me , H , -] , [ZB981 ; G25 , H , Et , H , -] , [ZB982 ; G25 , H , Pr , H , -] , [ZB983 ; G25 , H , i-Pr , H , -] , [ZB984 ; G25 , H , c-Pr , H , -] , [ZB985 ; G25 , H , Ph , H , -] , [ZB986 ; G25 , H , OMe , H , -] , [ZB987 ; G 25 , H , OEt , H , -] , [ZB988 ; G25 , H , OPh , H , -] , [ZB989 ; G25 , H , CF.sub.3 , H , -] , [ ZB990 ; G25 , H , F , H , -] , [ZB991 ; G25 , H , Cl , H , -] , [ZB992 ; G25 , H , Br , H , -] , [ZB993 ; G25 , H , CN , H , -] , [ZB994 ; G25 , H , H , Me , -] , [ZB995 ; G25 , H , H , Et , -] , [ZB996 ; G25 , H , H , Pr , -] , [ZB997 ; G25 , H , H , i-Pr , -] , [ZB998 ; G25 , H , H , c-Pr , -] , [ZB999 ; G25 , H , H , Ph , -] , [ZB1000 ; G25 , H , H , OMe , -] , [ZB1001 ; G 25 , H , H , OEt , -] , [ZB1002 ; G25 , H , H , OPh , -] , [ZB1003 ; G25 , H , H , CF.sub.3 , -] , [ZB1004 ; G25 , H , H , F , -] , [ZB1005 ; G25 , H , H , Cl , -] , [ZB1006 ; G25 , H , H , Br , -] , [ZB1007 ; G25 , H , H , CN , -] , [ZB1008 ; G25 , Me , H , H , -] , [ZB1009 ; G25 , Me , Me , H , -] , [ZB1010 ; G25 , Me , Et , H , -] , [ZB1011 ; G25 , Me , Pr , H , -] , [ZB1012 ; G25 , Me , i-Pr , H , -] , [ZB1013 ; G25 , Me , c-Pr , H , -] , [ZB1014 ; G25 , Me , Ph , H , -] , [ZB1015 ; G25 , Me , OMe , H , -] , [ZB1 016 ; G25 , Me , OEt , H , -] , [ZB1017 ; G25 , Me , OPh , H , -] , [ZB1018 ; G25 , Me , CF.sub.3 , H , -] , [ZB1019 ; G25 , Me , F , H , -] , [ZB1020 ; G25 , Me , Cl , H , -] , [ZB10 21 ; G25 , Me , Br , H , -] , [ZB1022 ; G25 , Me , CN , H , -] , [ZB1023 ; G25 , Me , H , M e , -] , [ZB1024 ; G25 , Me , H , Et , -] , [ZB1025 ; G25 , Me , H , Pr , -] , [ZB1026 ; G25 , Me , H , i-Pr , -] , [ZB1027 ; G25 , Me , H , c-Pr , -] , [ZB1028 ; G25 , Me , H , Ph , -] , [ZB1029 ; G25 , Me , H , OMe , -] , [ZB103 0 ; G25 , Me , H , OEt , -] , [ZB1031 ; G25 , Me , H , OPh , -] , [ZB1032 ; G25 , Me , H , CF.sub.3 , -] , [ZB1033 ; G25 , Me , H , F , -] , [ZB1034 ; G25 , Me , H , Cl , -] , [ZB1035 ; G25 , Me , H , Br , -] , [ZB1036 ; G25 , Me , H , CN , -] , [ZB1037 ; G26 , H , H , H , -] , [ZB1038 ; G26 , H , Me , H , -] , [ZB1039 ; G26 , H , Et , H , -] , [ZB1040 ; G26 , H , Pr , H , -] , [ZB1041 ; G26 , H , i-Pr , H , -] , [ZB1042 ; G26 , H , c-Pr , H , -] , [ZB1043 ; G26 , H , Ph , H , -] , [ZB1044 ; G26 , H , OMe , H , -] , [ZB104 5 ; G26 , H , OEt , H , -] , [ZB1046 ; G26 , H , OPh , H , -] , [ZB1047 ; G26 , H , CF.sub.3 , H , -] , [ZB1048 ; G26 , H , F ,H , -] , [ZB1049 ; G26 , H , Cl , H , -] , [ZB1050 ; G26 , H , Br , H , -] , [ZB1051 ; G26 , H , CN , H , -] , [ZB1052 ; G26 , H , H , Me , -] , [ZB10 53 ; G26 , H , H , Et , -] , [ZB1054 ; G26 , H , H , Pr , -] , [ZB1055 ; G26 , H , H , i-Pr , -] , [ZB1056 ; G26 , H , H , c-Pr , -] , [ZB1057 ; G26 , H , H , Ph , -] , [ZB1058 ; G26 , H , H , OMe , -] , [ZB1059 ; G26 , H , H , OEt , -] , [ZB1060 ; G26 , H , H , OPh , -] , [ZB1061 ; G26 , H , H , CF.sub.3 , -] , [ZB1062 ; G26 , H , H , F, -] , [ZB1063 ; G26 , H , H , Cl , -] , [ZB1064 ; G26 , H , H , Br , -] , [ZB1065 ; G26 , H , H , CN , -] , [ZB1066 ; G26 , Me , H , H , -] , [ZB1067 ; G26 , Me , Me , H , -] , [ZB1068 ; G26 , Me , Et , H , -] , [ZB1069 ; G26 , Me , Pr , H , -] , [ZB1070 ; G26 , Me , i-Pr , H , -] , [ZB1071 ; G26 , Me , c-Pr , H , -] , [ZB1072 ; G26 , Me , Ph , H , -] , [ZB1073 ; G26 , Me , OMe , H , -] , [ZB1 074 ; G26 , Me , OEt , H , -] , [ZB1075 ; G26 , Me , OPh , H , -] , [ZB1076 ; G26 , Me , CF.sub.3 , H , -] , [ZB1077 ; G26 , Me , F , H , -] , [ZB1078 ; G26 , Me , Cl , H , -] , [ZB10 79 ; G26 , Me , Br , H , -] , [ZB1080 ; G26 , Me , CN , H , -] , [ZB1081 ; G26 , Me , H , M e , -] , [ZB1082 ; G26 , Me , H , Et , -] , [ZB1083 ; G26 , Me , H , Pr , -] , [ZB1084 ; G26 , Me , H , i-Pr , -] , [ZB1085 ; G26 , Me , H , c-Pr , -] , [ZB1086 ; G26 , Me , H, Ph , -] , [ZB1087 ; G26 , Me , H , OMe , -] , [ZB108 8 ; G26 , Me , H , OEt , -] , [ZB1089 ; G26 , Me, H , OPh , -] , [ZB1090 ; G26 , Me , H , CF.sub.3 , -] , [ZB1091 ; G26 , Me , H , F , -] , [ZB1092 ; G26 , Me , H , Cl , -] , [ZB1093 ; G26 , Me , H , Br , -] , [ZB1094 ; G26 , Me , H , CN , -] , [ZB1095 ; G27 , H , H , H , -] , [ZB1096 ; G27 , Me , H , H , -] , [ZB1097 ; G27 , Et , H , H , -] , [ZB1098 ; G27 , Pr , H , H , -] , [ZB1099 ; G27 , i-Pr , H , H , -] , [ZB1100 ; G27 , c-Pr , H , H , -] , [ZB1101 ; G27 , Ph ,H , H , -] , [ZB1102 ; G27 , OMe , H , H , -] , [ZB1 103 ; G27 , OEt , H , H , -] , [ZB1104 ; G27 , OPh , H , H , -] , [ZB1105 ; G27 , CF.sub.3 , H , H , -] , [ZB1106 ; G27 , F , H , H , -] , [ZB1107 ; G27 , Cl , H , H , -] , [ZB1108 ; G2 7 , Br , H , H , -] , [ZB1109 ; G27 , CN , H , H , -] , [ZB1110 ; G27 , H , Me , H , -] , [ZB 1111 ; G27 , H , Et , H , -] , [ZB1112 ; G27 , H , Pr , H , -] , [ZB1113 ; G27 , H , i-Pr , H , -] , [ZB1114 ; G27 , H , c-Pr , H , -] , [ZB1115 ; G27 , H , Ph , H , -] , [ZB1116 ; G27 , H , OMe , H , -] , [ZB111 7 ; G27 , H , OEt , H , -] , [ZB1118 ; G27 , H , OPh , H , -] , [ZB1119 ; G27 , H , CF.sub.3 , H , -] , [ZB1120 ; G27 , H , F , H , -] , [ZB1121 ; G27 , H , Cl , H , -] , [ZB1122 ; G27 , H , Br , H , -] , [ZB1123 ; G27 , H , CN , H , -] , [ZB1124 ; G27 , H , H , Me , -] , [ZB1125 ; G27 , H , H , Et , -] , [ZB1126 ; G27 , H , H , Pr , -] , [ZB1127 ; G27 , H , H , i-Pr , -] , [ZB1128 ; G27 , H , H , c-Pr , -] , [ZB1129 ; G27 , H , H , Ph , -] , [ZB1130 ; G27 , H , H , OMe , -] , [ZB1131 ; G27 , H , H , OEt , -] , [ZB1132 ; G27 , H , H ,OPh , -] , [ZB1133 ; G27 , H , H , CF.sub.3 , -] , [ZB1134 ; G27 , H , H , F , -] , [ZB1135 ; G27 , H , H , Cl , -] , [ZB1136 ; G27 , H , H , Br , -] , [ZB1137 ; G27 , H , H , CN , -] , [ZB1138 ; G28 , H , H , - , -] , [ZB1139 ; G28 , Me , H , - , -] , [ZB1140 ; G28 , Cl , H , - , -] , [ZB1141 ; G28 , CF.sub.3, H , - , -] , [ZB1142 ; G28 , H , Me , - , -] , [ZB1143 ; G28 , H , Cl , - , -] , [ZB1144 ; G28 , H , C F.sub.3 , - , -] , [ZB1145 ; G28 , H , SH , - , -] , [ZB1146 ; G29 , H , H , H , -] , [ZB1147 ; G29 , H, Me , H , -] , [ZB1148 ; G29 , H , Et , H , -] , [ZB1149 ; G29 , H , Pr , H , -] , [ ZB1150 ; G29 , H , i-Pr , H , -] , [ZB1151 ; G29 , H , c-Pr , H , -] , [ZB1152 ; G29 , H , Ph , H , -] , [ZB1153 ; G29 , H , OMe , H , -] , [ZB115 4 ; G29 , H , OEt , H , -] , [ZB1155 ; G29 , H , OPh , H , -] , [ZB1156 ; G29 , H , CF.sub.3 , H , -] , [ZB1157 ; G29 , H , F , H , -] , [ZB1158 ; G29 , H , Cl , H , -] , [ZB1159 ; G29 , H , Br , H , -] , [ZB1160 ; G29 , H , CN , H , -] , [ZB1161 ; G29 , H ,H , Me , -] , [ZB11 62 ; G29 , H , H , Et , -] , [ZB1163 ; G29 , H , H , Pr , -] , [ZB1164 ; G29 , H , H , i-Pr , -] , [ZB1165 ; G29 , H , H , c-Pr , -] , [ZB1166 ; G29 , H , H, Ph , -] , [ZB1167 ; G29 , H , H , OMe , -] , [ZB1168 ; G29 , H, H , OE t , -] , [ZB1169 ; G29 , H , H , OPh , -] , [ZB1170 ; G29 , H , H , CF.sub.3 , -] , [ZB1171 ; G29 , H , H ,F , -] , [ZB1172 ; G29 , H , H , Cl , -] , [ZB1173 ; G29 , H , H , Br , -] , [ZB1174 ; G29 , H , H , CN , -] , [ZB1175 ; G29 , Me , H , H , -] , [ZB1176 ; G29 , Me , Me , H , -] , [ZB1177 ; G29 , Me , Et , H , -] , [ZB1178 ; G29 , Me , Pr , H , -] , [ZB1179 ; G29 , Me , i-Pr , H , -] , [ZB1180 ; G29 , Me , c-Pr , H , -] , [ZB1181 ; G29 , Me , Ph , H , -] , [ZB1182 ; G29 , Me , OMe, H , -] , [ZB1 183 ; G29 , Me , OEt , H , -] , [ZB1184 ; G29 , Me , OPh , H , -] , [ZB1185 ; G29 , Me , CF.sub.3 , H , -] , [ZB1186 ; G29 , Me , F , H , -] , [ZB1187 ; G29 , Me , Cl , H , -] , [ZB11 88 ; G29 , Me , Br , H , -] , [ZB1189 ; G29 , Me , CN , H , -] , [ZB1190 ; G29 , Me , H , M e , -] , [ZB1191 ; G29 , Me , H , Et , -] , [ZB1192 ; G29 , Me , H , Pr , -] , [ZB1193 ; G29 , Me , H , i-Pr , -] , [ZB1194 ; G29 , Me , H , c-Pr , -] , [ZB1195 ; G29 , Me , H , Ph , -] , [ZB1196 ; G29 , Me , H , OMe , -] , [ZB119 7 ; G29 , Me , H , OEt , -] , [ZB1198 ; G29 , Me , H , OPh , -] , [ZB1199 ; G29 , Me , H , CF.sub.3 , -] , [ZB1200 ; G29 , Me , H , F, -] , [ZB1201 ; G29 , Me , H , Cl , -] , [ZB1202 ; G29 , Me , H , Br , -] , [ZB1203 ; G29 , Me , H , CN , -] , [ZB1204 ; G30 , H , H , H , -] , [ZB1205 ; G30 , Me , H , H , -] , [ZB1206 ; G30 , Et , H , H , -] , [ZB1207 ; G30 , Pr , H , H , -] , [ZB1208 ; G30 , i-Pr , H , H , -] , [ZB1209 ; G30 , c-Pr , H , H , -] , [ZB1210 ; G30 , Ph , H , H , -] , [ZB1211 ; G30 , OMe , H , H , -] , [ZB1 212 ; G30 , OEt , H , H , -] , [ZB1213 ; G30 , OPh , H ,H , -] , [ZB1214 ; G30 , CF.sub.3 , H , H , -] , [ZB1215 ; G30 , F , H , H , -] , [ZB1216 ; G30 , C1 ,H , H , -] , [ZB1217 ; G3 0 , Br , H , H , -] , [ZB1218 ; G30 , CN , H , H , -] , [ZB1219 ; G30 , H , Me , H , -] , [ZB 1220 ; G30 , H, Et , H , -] , [ZB1221 ; G30 , H , Pr , H , -] , [ZB1222 ; G30 , H , i-Pr , H , -] , [ZB1223 ; G30 , H , c-Pr , H , -] , [ZB1224 ; G30 , H , Ph , H , -] , [ZB1225 ; G30 , H , OMe , H , -] , [ZB122 6 ; G30 , H , OEt , H , -] , [ZB1227 ; G30 , H , OPh , H , -] , [ZB1228 ; G30 , H , CF.sub.3 , H , -] , [ZB1229 ; G30 , H , F , H , -] , [ZB1230 ; G30 , H , C1 , H , -] , [ZB1231 ; G30 , H , Br ,H , -] , [ZB1232 ; G30 , H , CN , H , -] , [ZB1233 ; G30 , H , H , Me , -] , [ZB12 34 ; G30 , H , H , Et , -] , [ZB1235 ; G30 , H , H , Pr , -] , [ZB1236 ; G30 , H , H ,i-Pr , -] , [ZB1237 ; G30 , H , H , c-Pr , -] , [ZB1238 ; G30 , H , H , Ph , -] , [ZB1239 ; G30 , H , H , OMe , -] , [ZB1240 ; G30 , H , H , OEt , -] , [ZB1241 ; G30 , H , H , OPh , -] , [ZB1242 ; G30 , H , H , CF.sub.3 , -] , [ZB1243 ; G30 , H , H , F , -] , [ZB1244 ; G30 , H , H , Cl , -] , [ZB1245 ; G30 , H , H , Br , -] , [ZB1246 ; G30 , H , H , CN , -] , [ZB1247 ; G30 , H , Oi-Pr , H , -] , [ZB1248 ; G30 , H, Oc-Pr , H , -] , [ZB1249 ; G30 , H , Ot-Bu , H , -] , [ZB1250 ; G30 , H , OCF.sub.3 , H , -] , [ZB1251 ; G30 , H , OCHF.sub.2 , H , -] , [Z B1252 ; G30 , H , OPr , H , -] , [ZB1253 ; G30 , H , OCH.sub.2Ph , H , -] , [ZB1253 ; G30 , H , OCH.sub.2-i-Pr , H , -] , [ZB1253 ; G30 , H , OCH.sub.2-c-Pr , H , -] , [ZB1253 ; G30 , H , OCH.sub.2-t-Bu , H , -] , [ZB1254 ; G31 , H ,- , - , -] , [ZB1255 ; G31 , Me , - , - , -] , [ZB1256 ; G31 , Et , - , - , -] , [ZB1257 ; G31 , Pr , - , - , -] , [ZB1258 ; G31 , i-Pr , - , - , -] , [ZB1259 ; G31 , c-Pr , - , - , -] , [ZB1260 ; G31 , Ph , - , - , -] , [ZB1261 ; G31 , OMe , - , - , -] , [ZB1 262 ; G31 , OEt , - , - , -] , [ZB1263 ; G31 , OPh , - , - , -] , [ZB1264 ; G31 , CF.sub.3 , -, - , -] , [ZB1265 ; G31 , F , - , - , -] , [ZB1266 ; G31 , C1 , - , - , -] , [ZB1267 ; G3 1 , Br , - , - , -] , [ZB1268 ; G31 , CN , - , - , -] , [ZB1269 ; G31 , t-Bu , - , - , -] , [ZB1270 ; G32 , H , - , - , -] , [ZB1271 ; G32 , Me , - , - , -] , [ZB127 2 ; G32 , Et , - , - , -] , [ZB1273 ; G32 , Pr , - , - , -] , [ZB1274 ; G32 , i-Pr , - , - , -] , [ZB1275 ; G32 , c-Pr , - , - , -] , [ZB1276 ; G32 , Ph, - , - , -] , [ZB1277 ; G32 , OMe , - , - , -] , [ZB1 278 ; G32 , OEt , - , - , -] , [ZB1279 ; G32 , OPh , - , - , -] , [ZB1280 ; G32 , CF.sub.3 , -, - , -] , [ZB1281 ; G32 ,F , - , - , -] , [ZB1282 ; G32 , Cl , - , - , -] , [ZB1283 ; G3 2 , Br , - , - , -] , [ZB1284 ; G32 , CN , - , - , -] , [ZB1285 ; G32 , t-Bu , - , - , -] , [ZB1286 ; G33 , H , - , - , -] , [ZB1287 ; G33 , Me , - , - , -] , [ZB128 8 ; G33 , Et , - , - , -] , [ZB1289 ; G33 , Pr , - , - , -] , [ZB129G ; G33 , i-Pr , - , - , -] , [ZB1291 ; G33 , c-Pr , - , - , -] , [ZB1292 ; G33 , Ph , - , - , -] , [ZB1293 ; G33 , OMe , - , - , -] , [ZB1 294 ; G33 , OEt , - , - , -] , [ZB1295 ; G33 , OPh , - , - , -] , [2B1296 ; G33 , CF.sub.3 , -, - , -] , [ZB1297 ; G33 , F , - , - , -] , [ZB1298 ; G33 , Cl , - , - , -] , [ZB1299 ; G3 3 , Br , - , - , -] , [ZB1300 ; G33 , CN , - , - , -] , [ZB1301 ; G33 , t-Bu , - , - , -] , [ZB1302 ; G34 , H , - , - , -] , [ZB1303 ; G34 , Me , - , - , -] , [ZB130 4 ; G34 , Et , - , - , -] , [ZB1305 ; G34 , Pr , - , - , -] , [ZB1306 ; G34 , i-Pr , - , - , -] , [ZB1307 ; G34 , c-Pr , - , - , -] , [ZB1308 ; G34 , Ph , - , - , -] , [ZB1309 ; G34 , OMe , - , - , -] , [ZB1 310 ; G34 , OEt , - , - , -] , [ZB1311 ; G34 , OPh , - , - , -] , [ZB1312 ; G34 , CF.sub.3 , -, - , -] , [ZB1313 ; G34 , F , - , - , -] , [ZB1314 ; G34 , Cl , - , - , -] , [ZB1315 ; G3 4 , Br , - , - , -] , [ZB1316 ; G34 , CN , - , - , -] , [ZB1317 ; G34 , t-Bu , - , - , -] , [ZB1318 ; G12 , t-Bu , H , H , -] , [ZB1319 ; G12 , CH(Me)Et , H , H , -] , [ZB1320 ; G12 , CH(Et).sub.2 , H , H , -] , [ZB1321 ; G12 , CH.sub.2(i-Pr) , H , H , -] , [ZB1322 ; G12 , C(Me)=CH(Me) , H , H , -] , [ZB1323 ; G12 , C(Me )=CH.sub.2 , H , H , -] , [ZB1324 ; G12 , CH=CH(Me) , H , H , -] , [ZB1325 ; G12 , CH=CH .sub.2 , H , H , -] , [ZB1326 ; G12 , CC(c-Pr) , H , H , -] , [ZB1327 ; G12 , CC(Me) , H , H , -] , [ZB1328 ; G12 , CHF.sub.2 , H , H , -] , [ZB1329 ; G12 , CF.sub.2Me , H , H , -] , [ZB1330 ; G12 , CF.sub.2CF.sub.3 , H , H , -] , [ZB1331 ; G12 , C(CF.sub.3)CH.sub.2 , H , H , -] , [ZB1332 ; G12 , CF.sub.2Cl , H , H , -] , [ZB1333 ; G12 , C H(Me)CF.sub.3 , H , H , -] , [ZB1334 ; G12 , c-Bu , H , H , -] , [ZB1335 ; G12 , c-Pen , H , H , -] , [ZB1336 ; G12 , c-Hex , H , H , -] , [ZB1337 ; G12 , 1-Me-(c-Pr) , H , H , -] , [ZB1338 ; G12 , 1-F-(c-Pr) , H , H , -] , [ZB1339 ; G12 , 2 , 2-F.sub.2-(.sub.C-Pr) , H , H , -] , [ZB1340 ; G12 , I , H , H , -] , [ZB1341 ; G12 , CH.sub.2CN , H , H , -] , [Z B1342 ; G12 , CH.sub.2OMe , H , H , -] , [ZB1343 ; G12 , CH.sub.2SMe , H , H , -] , [ZB1344 ; G 12 , c-hexen-1-yl , H , H , -] , [ZB1345 ; G12 , OPr , H , H , -] , [ZB1346 ; G12 , O(i-Pr) , H , H , -] , [ZB1347 ; G12 , OCHF.sub.2 , H , H , -] , [ZB1348 ; G12 , SCF.sub.3 , H , H , -] , [ZB1349 ; G12 , C(Me)=NOMe , H , H , -] , [ZB1350 ; G12 , H , t-Bu , H , -] , [ZB1351 ; G12 , H , c-Bu , H , -] , [ZB1352 ; G12 , H , c-Pen , H , -] , [ZB1353 ; G12 , H , CCH , H , -] , [ZB1354 ; G12 , H , CH.sub.2OMe , H , -] , [ ZB1355 ; G12 , H , I , H , -] , [ZB1356 ; G12 , H , S(i-Pr) , H , -] , [ZB1357 ; G12 , Me , Me , H , -] , [ZB1358 ; G12 , Pr , Me , H , -] , [ZB1 359 ; G12 , i-Pr , Me , H , -] , [ZB1360 ; G12 , CHF.sub.2 , Me , H , -] , [ZB1361 ; G12 , CF.sub.3 , Me , H , -] , [ZB1362 ; G12 , c-Pr , Me , H , -] , [ZB1363 ; G12 , c-Hex , Me , H , -] , [ZB1364 ; G12 , OMe , Me , H , -] , [ZB1365 ; G12 , O(i-Pr) , Me , H , -] , [ZB1366 ; G12 , F , Me , H , -] , [ZB1367 ; G12 , Cl , Me , H , -] , [Z B1368 ; G12 , Br , Me , H , -] , [ZB1369 ; G12 , i-Pr , F , H , -] , [ZB1370 ; G12 , Me , F , H , -] , [ZB1371 ; G12 , Pr , F , H , -] , [ZB13 72 ; G12 , CHF.sub.2 , F, H , -] , [ZB1373 ; G12 , CF.sub.3 , F , H , -] , [ZB1374 ; G12 , c-Pr , F , H , -] , [ZB1375 ; G12 , c-Hex , F , H , -] , [ZB1376 ; G12 , OMe , F , H , -] , [ZB1377 ; G12, O(i-Pr) , F , H , -] , [ZB1378 ; G12 , F , F , H , -] , [ZB1379 ; G12 , Cl , F , H , -] , [ZB13 80 ; G12 , Br , F , H , -] , [ZB1381 ; G12 , Pr , Cl , H , -] , [ZB1382 ; G12 , i-Pr , Cl , H , -] , [ZB1383 ; G12 , c-Hex , Cl , H , -] , [ZB1384 ; G12 , Cl , Cl , H , -] , [ZB1385 ; G12 , O(i-Pr) , Cl , H , -] , [ZB1386 ; G12 , Me , Cl , H , -] , [ZB1387 ; G12 , CHF.sub.2 , Cl , H , -] , [ZB1388 ; G12 , CF.sub.3 , Cl , H , -] , [ZB1389 ; G12 , c-Pr , Cl , H , -] , [ZB1390 ; G12 , OMe , Cl , H , -] , [ZB1391 ; G12 , F , Cl , H , -] , [Z B1392 ; G12 , Br , Cl , H , -] , [ZB1393 ; G12 , Me , Br , H , -] , [ZB1394 ; G12 , c-Hex , Br , H , -] , [ZB1395 ; G12 , Pr , Br ,H , -] , [ZB1396 ; G12 , i-Pr , Br , H , -] , [ ZB1397 ; G12, CHF.sub.2, Br , H , -] , [ ZB1398 ; G12 , CF.sub.3 , Br , H , -] , [ZB1399 ; G12 , c-Pr,Br,H,-],[ZB1400;G12,OMe,Br,H,-],[ZB1401;G12,O(i-Pr),Br,H,-],[ZB1402;G12,F,Br,H,-],[ZB1403;G12,Cl,Br,H,-],[Z B1404;G12,Br,Br,H,-],[ZB1405;G22,H,Bu,-,-],[ZB1406;G22,H,CH .sub.2(i-Pr) ,-,-], [ZB1407;G22,H,c-Bu,-,-], [ZB1408;G22,H,c-Pen,-,-],[ZB1409;G22,H,c-Hex,-,-],[ZB1410;G22,H,c-hexen-1-yl, -, -], [ZB1411; G22 , H, CHF.sub.2, -, - ] , [ZB14 12 ; G22 , H, CF.sub.2CF.sub.3, -, -] ,[Z B1413; G22, H, CH=CH.sub.2, -, -] , [ZB1414; G22, H, C (Me) =CH.sub.2, -, -] , [ZB141 5;G22,H,CC(c-Pr),-,-], [ZB1415;G22,H,CC(i-Pr),-,-],[ZB1417;G22,H,CC(Me),-,-],[ZB1418;G22,H,CH=NOMe,-, -], [ZB1419;G22,H,C(Me)=NOMe,-,-],[ZB1420;G22,H,CH.sub.2O(i-Pr) ,- ,-], [ZB1421;G22,H,CH.sub.2OEt, -, -] , [ZB1422;G22,H,CH.sub.2OPh, -, -],[ZB1423;G22,Me,H,-,-],[ZB1424;G22,Et,H,-,-],[ZB1425;G22,P r,H,-,-], [ZB1426;G22,Bu,H,-,-], [ZB1427;G22,CH.sub.2(i-Pr) , H, -, -] , [ 2B1428; G22, c-Bu, H, -, -] , [ ZB1429; G22, c-Pen,H,-,-],[ZB1430;G22,c-Hex,H,-,-],[ZB1431;G22,c-hexen-1-yl, H, - , - ] , [ZB1432;G22, CHF.sub.2, H, -, -] , [ZB1433;G22, CF.sub.2CF.sub.3, H, -, -] , [ZB1434;G22,CN,H,-,-], [ZB1435;G22,OMe,H,-,-], [ZB1436;G22,CH =CH.sub.2,H,-,-], [ZB1437;G22,C(Me)=CH.sub.2, H,-,-] , [ZB1438;G22,CC(c-Pr),H,-,-],[ZB1439;G22,CC(i-Pr) , H,-,-] , [ZB1440;G22, CC (Me) , H, -, -] , [ZB1441;G22, CH=NOMe, H, -,-],[ZB1442;G22, C(Me)=NOMe,H,-,-],[ZB1443;G22,CH.sub.2O(i-Pr),H,-,-], [ZB1444;G22, CH.sub.2OEt, H, -,-], [ZB1445;G22,CH.sub.2OPh, H,-,-],[ZB1446;G22,Me,Me,-,-],[ZB1447;G22,Me,Et,-,-],[ZB1448;G 22,Me,i-Pr,-,-],[ZB1449;G22,Me,c-Pr,-,-],[ZB1450;G22,Me,c-Hex, -, -] , [ZB1451;G22,Me,CHF.sub.2, - , - ] , [ ZB1452 ; G22, Me,CF.sub.3, -, -], [ ZB1453;G22,Me,F,-,-], [ZB1454;G22,Me,Cl,-,-], [ZB1455;G22,Me, Br,-,-], [ZB1456;G22,Cl,Me,-,-], [ZB1457;G22,Cl,Et,-,-], [ZB14 58;G22,Cl,i-Pr,-,-],[ZB1459;G22,Cl,c-Pr,-,-],[ZB1460;G22,Cl,c-Hex, - , - ] , [ZB1461;G22,Cl,CHF.sub.2, -, -] , [ ZB1462 ; G22 , Cl, CF.sub.3, -, -] , [ ZB1463;G22, Cl,F, -, -] , [ZB1464; G22, Cl, Cl, -, -] , [ZB1465; G22, Cl, Br, -, -] , [ZB1466; G22, F, Me, -, -] , [ZB1467; G22, F, Et, -, -] , [ZB1468 ;G22, F, i-Pr, -, -], [ZB1469; G22, F, c-Pr, -, -] , [ZB1470; G22, F′, c-Hex,-,-], [ZB1471;G22,F,CHF.sub.2, -, -], [ZB1472;G22, F, CF.sub.3, -, -], [ZB 1473; G22, F, F, -, -] , [ZB1474;G22, F, Cl, -, -] , [ZB 1475; G22, F, Br, -, -], [ZB1476;G35,Me,H,-,-], [ZB1477;G35,Et,H,-,-], [ZB1478;G35, Pr,H,-,-] , [ZB1479; G35, Bu, H, -, -] , [ZB1480;G35, i-Pr, H, -, -], [ZB1481;G35, C(Me)=CH.sub.2, H, -, -], [ZB1482;G35, CHF.sub.2, H,-, -], [ZB1483;G35, CF.sub.3, H, -, -; , [ZB1484; G35, c-Pr, H, -, -] , [ZB1485;G35, c-Pen, H, -, -] , [ZB1486; G35, c-Hex,H,-,-],[ZB1487;G35,C(Me)=NOH,H,-,-], [ZB1488;G35,C(Me)=N OEt,H,-,-] , [ZB1489;G35,F,H,-,-],[ZB1490;G35,Cl,H,,[ZB14 91; G35, Br, H, -, -] , [ZB1492; G35, Me, C1, -, -] , [ZB14193; G35, Et, C1, -,-],[ZB1494;G35,Pr,Ci,-,-],[ZB1495;G35,Bu,Cl,-,-],[ZB1496;G 35, i-Pr, Cl, [ZB1497;G35,C(Me)=CH.sub.2, Cl, [ZB1498;G35, CHF.sub.2, C 1,-,-], [ZB1499; G35, CF.sub.3, Cl, -, - ] , [ ZB1500 ; G35, c-Pr,Cl,-,-], [ZB1501;G35,c-Pen,Cl,-,-],[ZB1502;G35,c-Hex, C1, -, -] , [ ZB1503; C35, C(Me)=NOH, Cl, -, -] , [ ZB1504; G35, C(Me) =NOEt, Cl, -, -] , [ZB1505; G35, F, C1, -, -] , [ZB1506; G35, C1, C1, -, -] , [ZB1507;G35,Br,Cl,-,-], [ZB1508;G35,Me,Br,-,-], [ZB1509;G35,E t, Br, -, -] , [ZB1510;G35, Pr, Br, -, -] , [ZB1511; G35, Bu, Br, -, -] , [ZB 1512;G35,i-Pr, Br, - , - ] , [ZB1513;G35, C (Me) =CH.sub.2, Br, -, -] , [ZB1514 ; G35, CHF.sub.2, B r,-,-], [ZB1515; G35, CF.sub.3, Br,-,-] [ZB1516;G35,c-Pr,Br,-,-], [ZB1517;G35,c-Pen,Br,-,-], [ZB1518;G35,c-Hex, Br, -, -] , [ZB1519; G35, C(Me)=NOH, Br, -, -] , [ ZB1520;G35, C(Me) =NOEt, Br, -, -] , [ZB1521; G35, F, Br, -, -] , [ZB1522; G35, Cl, Br, -, -] , [ZB1523; G35, Br, Br, -, -) , [ZB1524; G35, Me, Me, -, -] , [ZB1525; G35, E t,Me,-,-], [ZB1526;G35,Pr,Me,-,-], [ZB1527;G35,Bu,Me,-,-] , [ZB 1528;G35,i-Pr, Me, -,- , [ ZB1529; G35, C(Me) =CH.sub.2, Me, ZB1530; G35, CHF.sub.2, M e, -, -] , [ZB1531; G35, CF.sub.3, Me, -, -] , [ZB1532; G35, c-Pr,Me,-,-],[ZB1533;G35,c-Pen,Me,-,-],[ZB1534;G35,c-Hex, Me, -, -] , [ ZB1535; G35, C (Me)=NOH, Me, -, -] , [ ZB1536; G35, C(Me ) =NOEt,Me, -, -], [ZB1537;G35,F,Me, -, -], [ZB1538;G35,Cl,Me, -, -], [ZB1539; G35, Br, Me, -, -]

[1023] A compound (1J) wherein Q represents Q1, R.sup.1 represents a chlorine atom, and a combination of structure of G and substituents of R.sup.x7, R.sup.x8, R.sup.x9 and R.sup.x10 applied to the structure of G represents any combinations described in Combination B (hereinafter, referred to as Compound class SX137).

[1024] A compound (1J) wherein Q represents Q1, R.sup.1 represents a fluorine atom, and a combination of structure of G and substituents of R.sup.X7, R.sup.x8, R.sup.x9 and R.sup.x10 applied to the structure of G represents any combinations described in Combination B (hereinafter, referred to as Compound class SX138).

[1025] A compound (1J) wherein Q represents Q1, R.sup.1 represents an ethyl group, and a combination of structure of G and substituents of R.sup.x7, R.sup.x8, R.sup.x9 and R.sup.x10 applied to the structure of G represents any combinations described in Combination B (hereinafter, referred to as Compound class SX139).

[1026] A compound (1J) wherein Q represents Q1, R.sup.1 represents a cyclopropyl group, and a combination of structure of G and substituents of R.sup.x7, R.sup.x8, R.sup.x9 and R.sup.X10 applied to the structure of G represents any combinations described in Combination B (hereinafter, referred to as Compound class SX140).

[1027] A compound (1J) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, and a combination of structure of G and substituents of R.sup.x7, R.sup.,X8 R.sup.X9 and R.sup.x10 applied to the structure of G represents any combinations described in Combination B (hereinafter, referred to as Compound class SX141).

[1028] A compound (1J) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, and a combination of structure of G and substituents of R.sup.x7, R.sup.x8, R.sup.X9 and R.sup.X10 applied to the structure of G represents any combinations described in Combination B (hereinafter, referred to as Compound class SX142).

[1029] A compound (1J) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, and a combination of structure of G and substituents of R.sup.x7, R.sup.x8, R.sup.X9 and R.sup.X10 applied to the structure of G represents any combinations described in Combination B (hereinafter, referred to as Compound class SX143).

[1030] A compound (1J) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, and a combination of structure of G and substituents of R.sup.x7, R.sup.x8, R.sup.X9 and R.sup.X10 applied to the structure of G represents any combinations described in Combination B (hereinafter, referred to as Compound class SX144).

[1031] A compound represented by formula (1K):

##STR00176##

[1032] (hereinafter, referred to as “Compound (1K)”), [1033] wherein Q represents Q1, R.sup.1 represents a methyl group, and a combination of R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14, R.sup.x15.sub., R.sup.x16.sub., R.sup.X17, R.sup.X18, and R.sup.X19 represent any combinations described in Combination C (hereinafter, referred to as Compound Class SX145).

[1034] Combination C consists of substituent numbers ZC1 to ZC30.

[1035] Substituent numbers ZC1 to ZC30 represent combinations of R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14, R.sup.X15, R.sup.X16, R.sup.X17, R.sup.X18, and R.sup.X19 in .sub.the compound (1K), which hereinafter, is referred to as [Substituent No.; R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14, R.sup.X15, R.sup.X16, R.sup.X17, R.sup.X18, R.sup.X19]. For example, Substituent No. ZC2 represents a combination wherein R.sup.X11 represents a methyl group, and R.sup.X12, R.sup.X13, R.sup.X14, R.sup.x15.sub., R.sup.X16, R.sup.X17, R.sup.X18, and R.sup.X19 represent a hydrogen atom.

Combination C

[1036] [ZC2;H,H,H,H,H,H,H,H,H], [ZC2;Me,H,H,H,H,H,H,H,H],[ZC3;F,H,H , H, H, H, H, H H] , [ZC4; Cl, H, H, H, H, H, H, H, H] , [ZC5; H, F, F, H, H, H, H, H ,H], [ZC6;Me,F,F,H,H,H,H,H,H], [ZC7;F,F,F,H,H,H,H,H,H], [ZC8;C 1, F, F, H, H, H, H, H, H] , [ZC9; H, H, H, H, H, H, H, F, F] , [ZC10; Me, H, H, H, H , H, H, F, F] , [ZC11; F, H, H, H, H, H, H, F, F] , [ZC12 ; Cl, H, H, H, H, H, H, F, F ] , [ZC13; H, C1, C1, H, H, H, H, H, H] , [ ZC14 ; Me, Cl, Ci, H, H, H, H, H, H] , [ Z C15;F,Cl,Cl,H,H,H,H,H,H], [ZC16;Cl,Cl,Cl,H,H,H,H,H,H] , [ZC17; H, H, H, H, H, H, H, Cl, Cl] , [ZC18 ; Me, H, H, H, H, H, H, Cl, Cl] , [ZC19; F, H, H, H, H, H, H, Cl, Cl] , [ZC2O;C1, H, H, H, H, H, H, Cl, Cl] , [ZC21;H, H, H, F, F,H,H,H,H],[ZC22 ; H, H, H, Me, Me, H, H, H, H],[ZC23;H,H,H,Cl,Cl,H,H , H, H] , [ZC24 ; H, H, H, i-Pr,H,H,H,H,H] , [ZC2 5 ; H, H, H, CHF.sub.2, H, H, H, H, H ] , [ZC26; H, H, H, CF.sub.3, H , H, H, H, H] , [ZC27; H, H, H, CN, H, H, H, H, H] , [ZC28; H, H, H, OH, H, H, H, H, H ] , [ZC29; H, H, H, OMe, H, H, H, H, [ZC30; H, H, H, OCHF.sub.2, H, H, H, H, H

[1037] A compound (1K) wherein Q represents Q1, R.sup.1 represents a chlorine atom, and a combination of R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14, R.sup.X15, R.sup.X16, R.sup.X17, R.sup.X18, and R.sup.X19 represents any combinations described in the Combination C (hereinafter, referred to as Compound Class SX146).

[1038] A compound (1K) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, and a combination of R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14, R.sup.X15, R.sup.X16, R.sup.X17, R.sup.X18, and R.sup.X19 represents any combinations described in the Combination C (hereinafter, referred to as Compound Class SX147).

[1039] A compound (1K) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, and a combination of R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14, R.sup.X15, R.sup.X16, R.sup.X17, R.sup.X18, and R.sup.X19 represents any combinations described in the Combination C (hereinafter, referred to as Compound Class SX148).

[1040] A compound (1K) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, and a combination of R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14, R.sup.x15.sub., R.sup.X16, R.sup.X17, R.sup.X18, and R.sup.X19 represents any combinations described in the Combination C (hereinafter, referred to as Compound Class SX149).

[1041] A compound (1K) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, and a combination of R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14, R.sup.X15, R.sup.X16, R.sup.X17, R.sup.X18, and R.sup.X19 represents any combinations described in the Combination C (hereinafter, referred to as Compound Class SX150).

[1042] A compound represented by formula (1L):

##STR00177##

[1043] (hereinafter, referred to as “Compound (1L)”), [1044] wherein Q represents Q1, R.sup.1 represents a methyl group, and a combination of R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14, R.sup.X15, R.sup.X16and R.sup.X17 represent any combinations described in Combination E (hereinafter, referred to as Compound Class SX151).

[1045] Combination E consists of substituent numbers ZE1 to ZE20.

[1046] Substituent numbers ZE1 to ZE20 represent combinations of R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14, R.sup.X15, R.sup.X16, and R.sup.X17 in the compound (1L), which hereinafter, is referred to as [Substituent No.; R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14, R.sup.X15, R.sup.X16, R.sup.X17]. For example, Substituent No. ZE2 represents a combination wherein R.sup.X11 represents a methyl group, and R.sup.X12, R.sup.X13, R.sup.X14, R.sup.X15, R.sup.X16, and R.sup.X17 represent a hydrogen atom.

Combination E

[1047] [ZE1; H, H, H, H, H, H, H] , [ ZE2;Me, H, H, H, H, H, H] , [ZE3; F, H, H, H, H, H, H ] , [ZE4; Cl, H, H, H, H, H, H] , [ZE5;H, F, F, H, H, H, H] , [ZE6;Me, F, F, H, H, H,H], [ZE7;F, F, F, H, H, H, H] , [ZE8 ; Cl, F, F, H, H, H, H] , [ZE9; H, H, H, H, H, F, F] , [ZE10;Me,H,H,H,H,F, F] , [ZE11; F, H, H, H, H, F, F] , [ZE12;C1, H,H,H,H,F,F],[ZE13;H,Cl,Cl,H,H,H,H],[ZE14;Me,Cl,Cl,H,H,H,H] ,[ZE15;F,Cl,Cl,H,H,H,H],[ZE16;Cl,Cl,Cl,H,H,H,H],[ZE17;H,H,H ,H,H,Cl,Cl],[ZE18;Me,H,H,H,H,Cl,Cl],[ZE19;F,H,H,H,H,Cl,Cl] , [ZE20;Cl,H,H,H,H,Cl,Cl]

[1048] A compound (1L) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, and a combination of R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14, R.sup.X15, R.sup.X16, and R.sup.X17 represents any combinations described in the Combination E (hereinafter, referred to as Compound Class SX152).

[1049] A compound (1L) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a methyl group, and a combination of R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14, R.sup.X15, R.sup.X16, and R.sup.X17 represents any combinations described in the Combination E (hereinafter, referred to as Compound Class SX153).

[1050] A compound (1L) wherein Q represents Q2, L represents an oxygen atom, R.sup.1 represents a chlorine atom, and a combination of R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14, R.sup.X15, R.sup.X16, and R.sup.X17 represents any combinations described in the Combination E (hereinafter, referred to as Compound Class SX154).

[1051] A compound (1L) wherein Q represents Q2, L represents NH, R.sup.1 represents a methyl group, and a combination of R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14, R.sup.X15, R.sup.X16, and R.sup.X17 represents any combinations described in the Combination E (hereinafter, referred to as Compound Class SX155).

[1052] A compound (1L) wherein Q represents Q2, L represents NH, R.sup.1 represents a chlorine atom, and a combination of R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14, R.sup.X15, R.sup.X16, and R.sup.X17 represents any combinations described in the Combination E (hereinafter, referred to as Compound Class SX156).

[1053] A compound represented by formula (1M):

##STR00178##

[1054] (hereinafter, referred to as “Compound (1M)”), [1055] wherein R.sup.1 represents a methyl group, R.sup.X8 represents a hydrogen atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A [1056] (hereinafter, referred to as Compound Class SX157).

[1057] A compound (1M) wherein R.sup.1 represents a methyl group, R.sup.X8 represents a methyl group, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX158).

[1058] A compound (1M) wherein R.sup.1 represents a methyl group, R.sup.X8 represents a hydrogen atom, R.sup.X9 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX159).

[1059] A compound (1M) wherein R.sup.1 represents a methyl group, R.sup.X8 represents a fluorine atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX160).

[1060] A compound (1M) wherein R.sup.1 represents a methyl group, R.sup.X8 represents a hydrogen atom, R.sup.X9 represents a fluorine atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX161).

[1061] A compound (1M) wherein R.sup.1 represents a methyl group, R.sup.X8 represents a chlorine atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX162).

[1062] A compound (1M) wherein R.sup.1 represents a methyl group, R.sup.X8 represents a hydrogen atom, R.sup.X9 represents a chlorine atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX163).

[1063] A compound (1M) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a hydrogen atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.x3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX164).

[1064] A compound (1M) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a methyl group, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX165).

[1065] A compound (1M) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a hydrogen atom, R.sup.X9 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX166).

[1066] A compound (1M) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a fluorine atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX167).

[1067] A compound (1M) wherein R.sup.1 represents a chlorine atom, R.sup.X8represents a chlorine atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX168).

[1068] A compound (1M) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a chlorine atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.Xx3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX169).

[1069] A compound (1M) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a hydrogen atom, R.sup.X9 represents a chlorine atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX170).

[1070] A compound represented by formula (1N):

##STR00179##

[1071] (hereinafter, referred to as “Compound (1N)”), [1072] wherein R.sup.1 represents a methyl group, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX171).

[1073] A compound (1N) wherein R.sup.1 represents a hydrogen atom, R.sup.X9 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5 , and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX172) .

[1074] A compound (1N) wherein R.sup.1 represents a chlorine atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX173) .

[1075] A compound (1N) wherein R.sup.1 represents a chlorine atom, R.sup.X9 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX174).

[1076] A compound represented by formula (1O):

##STR00180##

[1077] (hereinafter, referred to as “Compound (1O)”), [1078] wherein R.sup.1 represents a methyl group, R.sup.X8 represents a hydrogen atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A [1079] (hereinafter, referred to as Compound Class SX175).

[1080] A compound (1O) wherein R.sup.1 represents a methyl group, R.sup.X8 represents a fluorine atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3,R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX176).

[1081] A compound (10) wherein R.sup.1 represents a methyl group, R.sup.X8 represents a chlorine atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX177).

[1082] A compound (10) wherein R.sup.1 represents a methyl group, R.sup.X8 represents a methyl group, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX178).

[1083] A compound (10) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a hydrogen atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3,R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX179).

[1084] A compound (10) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a fluorine atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3,R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX180).

[1085] A compound (10) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a chlorine atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX181).

[1086] A compound (10) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a methyl group, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.x3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX182).

[1087] A compound represented by formula (1P):

##STR00181##

[1088] (hereinafter, referred to as “Compound (1P)”), [1089] wherein R.sup.1 represents a methyl group, R.sup.X7 represents a hydrogen atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3,R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A [1090] (hereinafter, referred to as Compound Class SX183).

[1091] A compound (1P) wherein R.sup.1 represents a methyl group, R.sup.X7 represents a fluorine atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X3, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX184).

[1092] A compound (1P) wherein R.sup.1 represents a methyl group, R.sup.X7 represents a chlorine atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX185).

[1093] A compound (1P) wherein R.sup.1 represents a methyl group, R.sup.X7 represents a hydrogen atom, R.sup.X9 represents a fluorine atom, and a combination of R.sup.X2, R.sup.X3,R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX186).

[1094] A compound (1P) wherein R.sup.1 represents a chlorine atom, R.sup.X7 represents a hydrogen atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3,R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX187).

[1095] A compound (1P) wherein R.sup.1 represents a chlorine atom, R.sup.X7 represents a fluorine atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX188).

[1096] A compound (1P) wherein R.sup.1 represents a chlorine atom, R.sup.X7 represents a chlorine atom, R.sup.X9 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3,R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX189).

[1097] A compound (1P) wherein R.sup.1 represents a chlorine atom, R.sup.X7 represents a hydrogen atom, R.sup.X9 represents a fluorine atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX190).

[1098] A compound represented by formula (1Q):

##STR00182##

[1099] (hereinafter, referred to as “Compound (1Q)”), [1100] wherein R.sup.1 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A [1101] (hereinafter, referred to as Compound Class SX191).

[1102] A compound (1Q) wherein R.sup.1 represents a chlorine atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX192).

[1103] A compound represented by formula (1R):

##STR00183##

[1104] (hereinafter, referred to as “Compound (1R)”), [1105] wherein R.sup.1 represents a methyl group, and a combination of R.sup.X2, R.sup.X3,R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A [1106] (hereinafter, referred to as Compound Class SX193).

[1107] A compound (1R) wherein R.sup.1 represents a chlorine atom, and a combination of R.sup.X2, R.sup.X3,R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX194).

[1108] A compound represented by formula (1S):

##STR00184##

[1109] (hereinafter, referred to as “Compound (1S)”), [1110] wherein R.sup.1 represents a methyl group, R.sup.X7 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3,R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A [1111] (hereinafter, referred to as Compound Class SX195).

[1112] A compound (1S) wherein R.sup.1 represents a chlorine atom, R.sup.X7 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX196) .

[1113] A compound (1S) wherein R.sup.1 represents a methyl group, R.sup.X7 represents a fluorine atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX197).

[1114] A compound (1S) wherein R.sup.1 represents a chlorine atom, R.sup.X7 represents a fluorine atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX198).

[1115] A compound represented by formula (1T):

##STR00185##

[1116] (hereinafter, referred to as “Compound (1T)”), [1117] wherein R.sup.1 represents a methyl group, R.sup.X7 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3,R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A [1118] (hereinafter, referred to as Compound Class SX199).

[1119] A compound (1T) wherein R.sup.1 represents a chlorine atom, R.sup.X7 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX200).

[1120] A compound (1T) wherein R.sup.1 represents a methyl group, R.sup.X7 represents a fluorine atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX201) .

[1121] A compound (1T) wherein R.sup.1 represents a chlorine atom, R.sup.X7 represents a fluorine atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound Class SX202) .

[1122] A compound represented by formula (1U):

##STR00186##

[1123] (hereinafter, referred to as “Compound (1U)”), [1124] wherein A represents any one of formula AA1 to formula AA4.

[1125] R.sup.1 represents a methyl group, R.sup.X8 represents a hydrogen atom, R.sup.X9 represents a hydrogen atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX203).

[1126] Combination D consists of substituent numbers ZD1 to ZD334.

[1127] Substituent numbers ZD1 to ZD334 represent combinations of R.sup.X11, R.sup.X12, R.sup.X13, and R.sup.X14 in the compound (1U), a compound represented by formula (1V), a compound represented by formula (1W), a compound represented by formula (1X), a compound represented by formula (1Y), a compound represented by formula (1Z), a compound represented by formula (2A), which hereinafter, is referred to as [Substituent No.; A, R.sup.X11, R.sup.X12, R.sup.X13, R.sup.X14] . For example, Substituent No. ZD2 represents a combination wherein A represents AA1, R.sup.X11 represents a methyl group, and R.sup.X12, R.sup.X13, and R.sup.X14 represent a hydrogen atom.]

Combination D

[1128] [ZD1 ; AA1 , H , H , H , H] , [ZD2 ; AA1 , Me , H , H , H] , [ZD3 ; AA1 , Et , H , H , H] , [ZD 4 ; AA1 , Pr , H , H , H] , [ZD5 ; AA1 , i-Pr , H , H , H] , [ZD6 ; AA1 , c-Pr , H , H , H] ,[ZD7 ; AA1 , Ph , H , H , H] ,[ZD8 ; AA1 , OMe , H , H , H] , [ZD9 ; AA1 , O Et , H , H , H] , [ZD10 ; AA1 , OPh , H , H , H] , [ZD11 ; AA1 , CF.sub.3 , H , H , H] , [ZD12 ; A A1 , F , H , H , H] ,[ZD13 ; AA1 , Cl , H , H , H] , [ZD14 ; AA1 , Br , H , H , H] , [ZD15 ; A A1 , CN , H , H , H] , [ZD16 ; AA1 , H , Me , H , H] , [ZD17 ; AA1 , H , Et , H , H] ,[ZD18 ; AA1 , H , Pr , H , H] , [ZD19 ; AA1 , H , i-Pr , H , H] , [ZD20 ; AA1 , H ,c-Pr , H , H] , [ZD21 ; AA1 , H , Ph , H , H] , [ZD22 ; AA1 , H , OMe , H , H] , [ZD23 ; AA1 , H , OEt , H , H] , [ZD24 ; AA1 , H , OPh , H , 9 H] , [ZD25;AA1,H,CF.sub.3,H,H] , [ZD26 ; AA1 , H , F , H , H] , [ZD27 ; AA1 , H , C1 , H , H] , [ZD28 ; AA1 , H , Br , H , H] , [ZD29 ; AA1 , H , CN , H , H] , [ZD30 ; AA1 , H , H , Me , H] , [ZD31 ; AA1 , H , H , Et , H] , [ZD32 ; AA1 , H , H , Pr , H] , [ZD33 ; AA1 , H , H , i-Pr , H] , [ZD34 ; AA1 , H , H , c-Pr , H] , [ZD35 ; AA1 , H , H , Ph , H] , [ZD36 ; AA1 , H , H , OMe , H] , [ZD37 ; AA1 , H , H , OEt , H] , [ZD38 ; AA1 , H , H , OPh , H] , [ZD39 ; AA1 , H , H , CF.sub.3 , H] , [ZD40 ; AA 1 , H , H , F , H] , [ZD41 ; AA1 , H , H , Cl , H] , [ZD42 ; AA1 , H , H , Br , H] , [ZD43 ; AA 1 , H , H , CN ,H] , [ZD44 ; AA1 , H , H ,H , Me] , [ZD45 ; AA1 , H , H , H , Et] , [ZD46 ; A A1 , H , H , H , Pr] , [ZD47 ; AA1 , H , H , H , i-Pr] , [ZD48 ; AA1 , H , H , H, c-Pr] , [ZD49 ; AA1 , H , H , H , Ph] , [ZD50 ; AA1 , H , H , H , OMe] , [ZD51 ; AA1 , H , H , H , OEt] , [ZD52 ; AA1 , H, H , H , OPh] , [ZD53 ; AA1 , H , H, H , CF.sub.3] , [ZD54 ; AA1 , H , H , H , F] , [ZD55 ; AA1 , H , H , H ,Cl] , [ZD56 ; AA1 , H , H , H , Br] , [ZD57 ; AA1 , H , H , H , CN] , [ZD58 ; AA1 , Me , Me , H ,H] , [ZD59 ; AA1 , Me , Et , H , H] , [ZD60 ; A A1 , Me , OMe, H , H] , [ZD61 ; AA1 , Me , OEt , H , H] , [ZD62 ; AA1 , Me , SMe , H , H] , [ZD63 ; AA1 , Me , F , H , H] , [ZD64 ; AA1 , Me , Cl , H , H] , [ZD65 ; AA1 , Me , CN , H , H] , [ZD66 ; AA1 , F ,Me , H , H] , [ZD67 ; AA1 , F , Et , H ,H] , [ZD68 ; AA1 , F , OMe , H , H] , [ZD69 ; AA1 , F , OEt , H , H] , [ZD70 ; AA1 , F , SMe , H , H] , [ZD71 ; AA1 , F , F , H , H] , [ZD72 ; AA1 , F, Cl , H, H] , [ZD73 ; AA1 , F , CN , H , H] , [ZD74 ; AA1 , Cl , Me , H , H] , [ZD75 ; AA1 , Cl , Et , H , H] , [ZD76 ; AA1 , Cl , OMe , H , H] , [ZD77 ; A A1 , Cl , OEt , H , H] , [ZD78 ; AA1 , Cl , SMe , H , H] , [ZD79 ; AA1 , Cl , F , H , H] , [Z D80 ; AA1 , Cl , Cl , H , H] , [ZD81 ; AA1 , Cl , CN , H , H] , [ZD82 ; AA1 , OMe , Me , H , H] , [ZD83 ; AA1 , OMe , Et , H , H] , [ZD84 ; AA1 , OMe , OMe , H ,H] , [ZD85 ; AA1 , O Me , OEt , H , H] , [ZD86 ; AA1 , OMe , SMe , H , H] , [ZD87 ; AA1 , OMe , F , H , H] , [ZD 88 ; AA1 , OMe , Cl , H , H] , [ZD89 ; AA1 , OMe , CN , H , H] , [ZD90 ; AA1 , SMe , Me , H , H] , [ZD91 ; AA1 , SMe , Et , H , H] , [ZD92 ; AA1 , SMe , OMe , H , H] , [ZD93 ; AA1 , SMe , OEt , H , H] , [ZD94 ; AA1 , SMe , SMe , H , H] , [ZD95 ; AA1 , SMe , F, H , H] , [Z D96 ; AA1, SMe , Cl , H , H] , [ZD97 ; AA1 , SMe , CN , H , H] , [ZD98 ; AA2 , H , H , H , H ] , [ZD99 ; AA2 , Me , H , H , H] , [ZD100 ; AA2 , Et , H , H , H] , [ZD101 ; AA2 , Pr , H , H , H] , [ZD102 ; AA2 , i-Pr , H , H , H] , [ZD103 ; AA2 , c-Pr , H , H ,H] , [ZD104 ; AA2 , Ph , H , H , H] , [ZD105 ; AA2 , OMe , H , H, H] , [ZD106 ; AA2 , OEt , H , H , H] , [ZD107 ; AA2 , OPh , H , H , H] , [ZD108 ; AA2 , CF.sub.3 , H , H , H] , [ZD109 ; AA2 , F , H , H , H] , [ZD110 ; AA2 , Cl ,H , H , H] , [ZD111 ; AA2 , Br , H , H , H] , [ZD112 ; AA2 , CN , H , H , H] , [ZD113 ; AA2 , H , Me , H , H ] , [ZD114 ; AA2 , H , Et , H , H] , [ZD115 ; AA2 , H , Pr , H ,H] , [ZD116 ; AA2 , H , i-Pr , H , H] , [ZD117 ; AA2 , H , c-Pr , H , H] , [ZD118 ; AA2 , H , Ph , H , H ] , [ZD119 ; AA2 , H , OMe , H , H] , [ZD120 ; A A2 , H , OEt , H , H] , [ZD121 ; AA2 , H , OPh , H , H] , [ZD122 ; AA2 , H , CF.sub.3, H , H] , [ ZD123 ; AA2 , H , F , H , H] , [ZD124 ; AA2 , H , Cl , H, H] , [ZD125 ; AA2 , H , Br , H , H ] , [ZD126 ; AA2 , H , CN , H , H] , [ZD127 ; AA2 , H , H , Me , H] , [ZD128 ; AA2 , H , H , Et , H] , [ZD129 ; AA2 , H , H , Pr , H] , [ZD130 ; AA2 , H , H , i-Pr , H] , [ZD131 ; AA2 , H , H , c-Pr , H] , [ZD132 ; AA2 , H , H , Ph , H] , [ZD133 ; AA2 , H , H , OMe , H] , [ZD134 ; AA2 , H , H , OEt , H] , [ZD135 ; AA2 , H , H , OPh , H] , [ZD136 ; AA2 , H , H , CF.sub.3 , H] , [ZD 137 ; AA2 , H , H , F , H] , [ZD138 ; AA2 , H , H , Cl , H] , [ZD139 ; AA2 , H , H , Br , H] , [ZD140 ; AA2 , H , H , CN , H] , [ZD141 ; AA2 , H , H , H , Me] , [ZD142 ; AA2 , H , H , H , Et] , [ZD143 ; AA2 , H , H , H , Pr] , [ZD144 ; AA2 , H, H , H , i-Pr] , [ZD145 ; AA2 , H , H , H , c-Pr] , [ZD146 ; AA2 , H , H , H , Ph] , [ZD147 ; AA2 , H , H , H , OMe] , [ZD148 ; AA2 , H , H , H , OEt] , [ZD149 ; AA2 , H , H , H , OPh] , [ZD150 ; AA2 , H , H , H , CF.sub.3] , [ZD15 1 ; AA2 , H ,H , H , F] , [ZD152 ; AA2 , H , H , H , Cl] , [ZD153 ; AA2 , H , H , H , Br] , [Z D154 ; AA2 , H , H , H , CN] , [ZD155 ; AA2 , Me , Me , H , H] , [ZD156 ; AA2 , Me , Et , H , H] , [ZD157 ; AA2 , Me , OMe , H , H] , [ZD158 ; AA2 , Me , OEt , H , H] , [ZD159 ; AA 2 , Me , SMe , H , H] , [ZD160 ; AA2 , Me , F, H , H] , [ZD161 ; AA2 , Me , Cl , H , H] , [Z D162 ; AA2 , Me , CN , H , H] , [ZD163 ; AA2 , F , Me , H , H ] , [ZD164 ; AA2 , F , Et , H , H] , [ZD165 ; AA2 , F , OMe , H , H ] , [ZD166 ; AA2 , F , OEt ,H , H] , [ZD167 ; AA 2 , F , SMe , H , H] , [ZD168 ; AA2 , F , F , H ,H ] , [ZD169 ; AA2 , F , Cl , H , H] , [ZD170 ; A A2 , F ,CN , H , H] , [ZD171 ; AA2 , Cl , Me , H , H] , [ZD172 ; AA2 , Cl , Et , H , H] , [Z D173 ; AA2 , Cl , OMe , H , H] , [ZD174 ; AA2 , Cl , OEt , H , H] , [ZD175 ; AA2 , Cl , S Me , H , H] , [ZD176 ; AA2 , Cl , F, H , H] , [ZD177 ; AA2 , Cl , Cl , H , H] , [ZD178 ; A A2 , Cl , CN , H , H] , [ZD179 ; AA2 , OMe , Me , H , H] , [ZD180 ; AA2 , OMe , Et , H , H] , [ZD181 ; AA2 , OMe , OMe , H , H] , [ZD182 ; AA2 , OMe , OEt , H , H] , [ZD183 ; AA2 , OMe , SMe , H , H] , [ZD184 ; AA2 , OMe , F , H , H] , [ZD185 ; AA2 , OMe , Cl , H , H] , [ZD186 ; AA2 , OMe , CN , H , H] , [ZD187 ; AA2 , SMe , Me , H , H] , [ZD188 ; AA2 , SM e , Et , H , H] , [ZD189 ; AA2 , SMe , OMe , H , H] , [ZD190 ; AA2 , SMe , OEt , H , H] ,[ ZD191 ; AA2 , SMe , SMe , H , H] , [ZD192 ; AA2 , SMe , F , H , H] , [ZD193 ; AA2 , SMe , Cl , H , H] , [ZD194 ; AA2 , SMe , CN , H , H] , [ZD195 ; AA3 , H , H , H , H] , [ZD196 ; AA3 , Me , H , H , H] , [ZD197 ; AA3 , Et , H , H, H] , [ZD198 ; AA3 , Pr , H, H , H] , [ZD 199 ; AA3 , i-Pr , H , H , H] , [ZD200 ; AA3 , c-Pr , H , H , H] , [ZD201 ; AA3 , Ph , H , H , H] , [ZD202 ; AA3 , OMe , H , H , H] , [ZD203 ; AA3 , OEt , H , H , H] , [ZD204 ; AA3 , OPh , H , H , H] , [ZD205 ; AA3 , CF.sub.3 , H , H , H] , [ZD206 ; AA3 , F , H , H , H] , [ZD207 ; AA3 , Cl , H , H , H] , [ZD208 ; AA3 , Br , H , H , H] , [ZD209 ; AA3 , CN , H , H , H] , [ZD210 ; AA3 , H , Me , H , H] , [ZD211 ; AA3 , H , Et , H , H] , [ZD212 ; AA3 , H , Pr , H , H] , [ZD213 ; AA3 , H , i-Pr , H , H] , [ZD214 ; AA3 , H , c-Pr , H , H] , [ZD215 ; AA3 , H , Ph , H , H] , [ZD216 ; AA3 , H , OMe , H , H] , [ZD217 ; A A3 , H , OEt , H , H] , [ZD218 ; AA3 , H , OPh , H , H] , [ZD219 ; AA3 , H , CF.sub.3 , H , H] , [ ZD220 : AA3 , H , F , H , H] , [ZD221 ; AA3 , H , Cl , H , H] , [ZD222 ; AA3 , H , Br , H , H ] , [ZD223 ; AA3 , H , CN , H , H] , [ZD224 ; AA3 , H , H , Me , H] , [ZD225 ; AA3 , H , H , Et , H] , [ZD226 ; AA3 , H , H , Pr , H] , [ZD227 ; AA3 , H , H , i-Pr , H] , [ZD228 ; AA3 , H , H , c-Pr , H] , [ZD229 ; AA3 , H , H , Ph , H] , [ZD230 ; AA3 , H , H , OMe , H] , [ZD231 ; AA3 , H , H , OEt , H] , [ZD232 ; AA3 , H , H , OPh , H] , [ZD233 ; AA3 , H , H , CF.sub.3 , H] , [ZD 234 ; AA3 , H , H , F , H ] , [ZD235 ; AA3, H , H , Cl , H] , [ZD236 ; AA3, H , H , Br , H] , [ZD237 ; AA3 , H , H, CN , H] , [ZD238 ; AA3 , H , H , H , Me] , [ZD239 ; AA3 , H , H , H , Et] , [ZD240 ; AA3 , H , H , H , Pr] , [ZD241 ; AA3 , H , H , H ,i-Pr] , [ZD242 ; AA3 , H , H, H , c-Pr] , [ZD243 ; AA3 , H , H , H , Ph] , [ZD244 ; AA3 , H , H ,H , OMe] , [ZD245 ; AA3 , H , H , H, OEt] , [ZD246 ; AA3 , H , H, H , OPh] , [ZD247 ; AA3 , H , H , H , CF.sub.3] , [ZD24 8 ; AA3 , H , H , H , F] , [ZD249 ; AA3 , H , H , H , Cl] , [ZD250 ; AA3 , H , H , H ,Br] , [Z D251 ; AA3 , H , H , H , CN] , [ZD252 ; AA3 , Me , Me , H , H] , [ZD253 ; AA3 , Me , Et , H , H] , [ZD254 ; AA3 , Me , OMe , H , H] , [ZD255 ; AA3 , Me, OEt , H , H] , [ZD256 ; AA 3 , Me , SMe , H , H] , [ZD257 ; AA3 , Me , F , H , H] , [ZD258 ; AA3 , Me , Cl , H , H] , [Z D259 ; AA3 , Me , CN , H , H] , [ZD260 ; AA3 , F, Me , H , H] , [ZD261 ; AA3 , F , Et , H , H] , [ZD262 ; AA3 , F , OMe , H , H] , [ZD263 ; AA3, F , OEt , H , H] , [ZD264 ; AA3 , F , SMe , H , H] , [ZD265 ; AA3 , F , F , H , H] , [ZD266 ; AA3 , F , Cl , H , H] , [ZD267 ; A A3 , F , CN , H , H] , [ZD268 ; AA3 , Cl , Me , H , H] , [ZD269 ; AA3 , Cl , Et , H , H] , [Z D270 ; AA3 , Cl , OMe , H , H] , [ZD271 ; AA3 , Cl , OEt , H , H] , [ZD272 ; AA3 , C1 , S Me , H , H] , [ZD273 ; AA3, Cl , F , H , H] , [ZD274 ; AA3 , Cl , Cl , H , H] , [ZD275 ; A A3 , Cl , CN , H , H] , [ZD276 ; AA3 , OMe , Me , H , H] , [ZD277 ; AA3 , OMe , Et , H , H] , [ZD278 ; AA3 , OMe , OMe , H , H] , [ZD279 ; AA3 , OMe , OEt , H , H] , [ZD280 ; AA3 , OMe , SMe , H , H] , [ZD281 ; AA3 , OMe , F , H , H] , [ZD282 ; AA3 , OMe , Cl , H , H] , [ZD283 ; AA3 , OMe , CN , H , H] , [ZD284 ; AA3 , SMe , Me , H , H] , [ZD285 ; AA3 , SM e , Et , H , H] , [ZD286 ; AA3 , SMe , OMe , H , H] , [ZD287 ; AA3 , SMe , OEt , H , H] , [ ZD288 ; AA3 , SMe , SMe , H , H] , [ZD289 ; AA3 , SMe , F , H , H] , [ZD290 ; AA3 , SMe , Cl , H , H] , [ZD291 ; AA3 , SMe , CN , H , H] , [ZD292 ; AA4 , H , H , H , -] , [ZD293 ; AA4 , Me , H , H , -] , [ZD294 ; AA4 , Et , H , H , -] , [ZD295 ; AA4 , Pr , H , H , -] , [ZD 296 ; AA4 , i-Pr , H , H , -] , [ZD297 ; AA4 , c-Pr , H , H , -] , [ZD298 ; AA4 , Ph , H , H , -] , [ZD299 ; AA4 , OMe , H , H , -] , [ZD300 ; AA4 , OEt , H , H , -] , [ZD301 ; AA4 , OPh , H , H , -] , [ZD302 ; AA4 , CF.sub.3 , H , H , -] , [ZD303 ; AA4 , F , H , H , -] , [ZD304 ; AA4 , Cl , H , H , -] , [ZD305 ; AA4 , Br , H , H , -] , [ZD306 ; AA4 , CN , H , H , -] , [ZD307 ; AA4 , H , Me , H, -] , [ZD308 ; AA4 , H , Et , H , -] , [ZD309 ; AA4 , H , Pr , H , -] , [ZD310 ; AA4 , H , i-Pr , H , -] , [ZD311 ; AA4 , H , c-Pr , H , -] , [ZD312 ; AA4 , H , Ph , H , -] , [ZD313 ; AA4 , H , OMe , H , -] , [ZD314 ; A A4 , H , OEt , H, -] , [ZD315 ; AA4 , H , OPh , H , -] , [ZD316 ; AA4 , H , CF.sub.3 , H , -] , [ ZD317;AA4,H,F,H,-], [ZD318;AA4,H,Cl,H,-], [ZD319;AA4,H,Br,H,-],[ZD320;AA4,H,CN,H,-],[ZD321;AA4,H,H,Me,-],[ZD322;AA4,H,H, Et,-],[ZD323;AA4,H,H,Pr,-],[ZD324;AA4,H,H,i-Pr,-],[ZD325;AA4,H,H,c-Pr,-],[ZD326;AA4,H,H,Ph,-],[ZD327;AA4,H,H,OMe,-],[ZD328;AA4 ,H,H,OEt,-],[ZD329;AA4,H,H,OPh,-],[ZD330;AA4,H,H,CF.sub.3-],[ZD 331;AA4,H,H,F,-],[ZD332;AA4,H,H,Cl,-],[ZD333;AA4,H,H,Br,-], [ZD334;AA4,H,H,CN,-]

[1129] A compound (1U) wherein R.sup.1 represents a methyl group, R.sup.X8 represents a fluorine atom, R.sup.X9 represents a hydrogen atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX204).

[1130] A compound (1U) wherein R.sup.1 represents a methyl group, R.sup.X8 represents a hydrogen atom, R.sup.X9 represents a fluorine atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX205).

[1131] A compound (1U) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a hydrogen atom, R.sup.X9 represents a hydrogen atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX206).

[1132] A compound (1U) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a fluorine atom, R.sup.X9 represents a hydrogen atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX207).

[1133] A compound (1U) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a hydrogen atom, R.sup.X9 represents a fluorine atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX208).

[1134] A compound represented by formula (1V):

##STR00191##

[1135] (hereinafter, referred to as “Compound (1V)”), [1136] wherein A represents any one of formula AA1 to formula AA4.

[1137] R.sup.1 represents a methyl group, R.sup.X8 represents a hydrogen atom, R.sup.X9 represents a hydrogen atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX209).

[1138] A compound (1V) wherein R.sup.1 represents a methyl group, R.sup.X9 represents a methyl group, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX210) .

[1139] A compound (1V) wherein R.sup.1 represents a chlorine atom, R.sup.X9 represents a hydrogen atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX211).

[1140] A compound (1V) wherein R.sup.1 represents a chlorine atom, R.sup.X9 represents a methyl group, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX212).

[1141] A compound represented by formula (1W):

##STR00196##

(hereinafter, referred to as “Compound (1W)”), wherein [1142] A represents any one of formula AA1 to formula AA4, [1143] R.sup.1 represents a methyl group, R.sup.X8 represents a hydrogen atom, R.sup.X9 represents a hydrogen atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX213).

[1144] A compound (1W) wherein R.sup.1 represents a methyl group, R.sup.X8 represents a fluorine atom, R.sup.X9 represents a hydrogen atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX214).

[1145] A compound (1W) wherein R.sup.1 represents a methyl group, R.sup.X8 represents a chlorine atom, R.sup.X9 represents a hydrogen atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX215).

[1146] A compound (1W) wherein R.sup.1 represents a methyl group, R.sup.X8 represents a methyl group, R.sup.X9 represents a hydrogen atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX216).

[1147] A compound (1W) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a hydrogen atom, R.sup.X9 represents a hydrogen atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX217).

[1148] A compound (1W) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a fluorine atom, R.sup.X9 represents a hydrogen atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX218).

[1149] A compound (1W) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a chlorine atom, R.sup.X9 represents a hydrogen atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX219).

[1150] A compound (1W) wherein R.sup.1 represents a chlorine atom, R.sup.X8 represents a methyl group, R.sup.X9 represents a hydrogen atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX220).

[1151] A compound represented by formula (1X):

##STR00197##

(hereinafter, referred to as “Compound (1X)”), wherein [1152] A represents any one of formula AA1 to formula AA4, [1153] R.sup.1 represents a methyl group, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX221).

[1154] A compound (1X) wherein R.sup.1 represents a chlorine atom, and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX222).

[1155] A compound represented by formula (1Y):

##STR00198##

(hereinafter, referred to as “Compound (1Y)”), wherein [1156] A represents any one of formula AA1 to formula AA4, [1157] R.sup.1 represents a methyl group, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX223).

[1158] A compound (1Y) wherein R.sup.1 represents a chlorine atom, and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX224).

[1159] A compound represented by formula (1Z):

##STR00199##

(hereinafter, referred to as “Compound (1Z)”), wherein [1160] A represents any one of formula AA1 to formula AA4, [1161] R.sup.1 represents a methyl group, R.sup.X7 represents a hydrogen atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX225).

[1162] A compound (1Z) wherein R.sup.1 represents a chlorine atom, R.sup.X7 represents a hydrogen atom, and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX226).

[1163] A compound (1Z) wherein R.sup.1 represents a methyl group, R.sup.X7 represents a fluorine atom, and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX227).

[1164] A compound (1Z) wherein R.sup.1 represents a chlorine atom, R.sup.X7 represents a fluorine atom, and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX228).

[1165] A compound represented by formula (2A):

##STR00200##

(hereinafter, referred to as “Compound (2A)”), wherein [1166] A represents any one of formula AA1 to formula AA4, [1167] R.sup.1 represents a methyl group, R.sup.X7 represents a hydrogen atom, and a combination of structure of A and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX229).

[1168] A compound (2A) wherein R.sup.1 represents a chlorine atom, R.sup.X7 represents a hydrogen atom, and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX230).

[1169] A compound (2A) wherein R.sup.1 represents a methyl group, R.sup.X7 represents a fluorine atom, and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX231).

[1170] A compound (2A) wherein R.sup.1 represents a chlorine atom, R.sup.X7 represents a fluorine atom, and substituents of R.sup.X11, R.sup.X12, R.sup.X13 and R.sup.X14 applied to the structure of A represents any combinations described in Combination D (hereinafter, referred to as Compound class SX232).

[1171] A compound represented by formula (2B):

##STR00201##

(hereinafter, referred to as “Compound (2B)”), wherein

[1172] Q represents Q1, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, and R.sup.7 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX233).

[1173] A compound (2B) wherein Q represents Q1, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, and R.sup.7 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX234).

[1174] A compound (2B) wherein Q represents Q1, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, and R.sup.7 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX235).

[1175] A compound (2B) wherein Q represents Q1, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, and R.sup.7 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX236).

[1176] A compound (2B) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, and R.sup.7 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX237).

[1177] A compound (2B) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, and R.sup.7 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX238).

[1178] A compound (2B) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, and R.sup.7 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX239).

[1179] A compound (2B) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, and R.sup.7 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX240) .

[1180] A compound (2B) wherein Q represents Q2, L represents NH, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, and R.sup.7 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX241).

[1181] A compound (2B) wherein Q represents Q2, L represents NH, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, and R.sup.7 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX242).

[1182] A compound (2B) wherein Q represents Q2, L represents NH, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, and R.sup.7 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX243).

[1183] A compound (2B) wherein Q represents Q2, L represents NH, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, and R.sup.7 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX244).

[1184] A compound represented by formula (2C):

##STR00202##

(hereinafter, referred to as “Compound (2C)”), wherein

[1185] Q represents Q1, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations selected from Combination A

[1186] (hereinafter, referred to as Compound class SX245).

[1187] A compound (2C) wherein Q represents Q1, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations selected from Combination A (hereinafter, referred to as Compound class SX246).

[1188] A compound (2C) wherein Q represents Q1, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations selected from Combination A (hereinafter, referred to as Compound class SX247).

[1189] A compound (2C) wherein Q represents Q1, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations selected from Combination A (hereinafter, referred to as Compound class SX248).

[1190] A compound (2C) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations selected from Combination A (hereinafter, referred to as Compound class SX249).

[1191] A compound (2C) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations selected from Combination A (hereinafter, referred to as Compound class SX250).

[1192] A compound (2C) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations selected from Combination A (hereinafter, referred to as Compound class SX251).

[1193] A compound (2C) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations selected from Combination A (hereinafter, referred to as Compound class SX252).

[1194] A compound (2C) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations selected from Combination A (hereinafter, referred to as Compound class SX253).

[1195] A compound (2C) wherein Q represents Q2, L represents NH, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations selected from Combination A (hereinafter, referred to as Compound class SX254).

[1196] A compound (2C) wherein Q represents Q2, L represents NH, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations selected from Combination A (hereinafter, referred to as Compound class SX255).

[1197] A compound (2C) wherein Q represents Q2, L represents NH, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations selected from Combination A (hereinafter, referred to as Compound class SX256).

[1198] A compound represented by formula (2D):

##STR00203##

(hereinafter, referred to as “Compound (2D)”), wherein

[1199] Q represents Q1, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX247).

[1200] A compound (2D) wherein Q represents Q1, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX258).

[1201] A compound (2D) wherein Q represents Q1, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX259).

[1202] A compound (2D) wherein Q represents Q1, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX260).

[1203] A compound (2D) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX261).

[1204] A compound (2D) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX262).

[1205] A compound (2D) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX263).

[1206] A compound (2D) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX264).

[1207] A compound (2D) wherein Q represents Q2, L represents NH, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX265).

[1208] A compound (2D) wherein Q represents Q2, L represents NH, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX266).

[1209] A compound (2D) wherein Q represents Q2, L represents NH, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX267).

[1210] A compound (2D) wherein Q represents Q2, L represents NH, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, R.sup.4 represents a methyl group, and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX268).

[1211] A compound (2D) wherein Q represents Q2, L represents NH, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, R.sup.4 represents a hydrogen atom and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX269).

[1212] A compound (2D) wherein Q represents Q1, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, R.sup.4 represents a hydrogen atom and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX270).

[1213] A compound (2D) wherein Q represents Q1, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, R.sup.4 represents a hydrogen atom and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX271).

[1214] A compound (2D) wherein Q represents Q1, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, R.sup.4 represents a hydrogen atom and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX272).

[1215] A compound (2D) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, R.sup.4 represents a hydrogen atom and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX273).

[1216] A compound (2D) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, R.sup.4 represents a hydrogen atom and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX274).

[1217] A compound (2D) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, R.sup.4 represents a hydrogen atom and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX275).

[1218] A compound (2D) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, R.sup.4 represents a hydrogen atom and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX276).

[1219] A compound (2D) wherein Q represents Q2, L represents NH, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, R.sup.4 represents a hydrogen atom and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX277).

[1220] A compound (2D) wherein Q represents Q2, L represents NH, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, R.sup.4 represents a hydrogen atom and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX278).

[1221] A compound (2D) wherein Q represents Q2, L represents NH, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, R.sup.4 represents a hydrogen atom and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX279).

[1222] A compound (2D) wherein Q represents Q2, L represents NH, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, R.sup.4 represents a hydrogen atom and R.sup.5 represents any substituents selected from Group X (hereinafter, referred to as Compound class SX280).

[1223] A compound represented by formula (2E):

##STR00204##

(hereinafter, referred to as “Compound (2E)”), wherein

[1224] Q represents Q1, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X5 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX281).

[1225] A compound (2E) wherein Q represents Q1, R.sup.22 represents a hydrogen atom, R.sup.23 represents a hydrogen atom, R.sup.23 represents a methyl group, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X5 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX282).

[1226] A compound (2E) wherein R.sup.22 represents a chlorine atom, Q represents Q1, R.sup.23 represents a hydrogen atom, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX283).

[1227] A compound (2E) wherein R.sup.22 represents a hydrogen atom, Q represents Q1, R.sup.23 represents a chlorine atom, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX284).

[1228] A compound (2E) wherein Q represents Q1, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX285).

[1229] A compound (2E) wherein Q represents Q1, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX286).

[1230] A compound (2E) wherein Q represents Q1, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX287).

[1231] A compound (2E) wherein Q represents Q1, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX288).

[1232] A compound (2E) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX289).

[1233] A compound (2E) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX290).

[1234] A compound (2E) wherein R.sup.22 represents a chlorine atom, Q represents Q2, L represents an oxygen atom, R.sup.23 represents a hydrogen atom, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX291).

[1235] A compound (2E) wherein R.sup.22 represents a hydrogen atom, Q represents Q2, L represents an oxygen atom, R.sup.23 represents a chlorine atom, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX292).

[1236] A compound (2E) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX293).

[1237] A compound (2E) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX294).

[1238] A compound (2E) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX295).

[1239] A compound (2E) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX296).

[1240] A compound (2E) wherein Q represents Q2, L represents NH, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX297).

[1241] A compound (2E) wherein Q represents Q2, L represents NH, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX298).

[1242] A compound (2E) wherein R.sup.22 represents a chlorine atom, Q represents Q2, L represents NH, R.sup.23 represents a hydrogen atom, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX299) .

[1243] A compound (2E) wherein R.sup.22 represents a hydrogen atom, Q represents Q2, L represents NH, R.sup.23 represents a chlorine atom, R.sup.4 represents a methyl group, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX300) .

[1244] A compound (2E) wherein Q represents Q2, L represents NH, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX301).

[1245] A compound (2E) wherein Q represents Q2, L represents NH, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX302).

[1246] A compound (2E) wherein Q represents Q2, L represents NH, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX303).

[1247] A compound (2E) wherein Q represents Q2, L represents NH, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, R.sup.4 represents a hydrogen atom, and a combination of R.sup.X2, R.sup.X3, R.sup.X4, R.sup.X5, and R.sup.X6 represents any combinations described in Combination A (hereinafter, referred to as Compound class SX304).

[1248] A compound represented by formula (2F):

##STR00205##

(hereinafter, referred to as “Compound (2F)”), wherein

[1249] Q represents Q1, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound class SX305).

[1250] A compound (2F) wherein Q represents Q1, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound class SX306).

[1251] A compound (2F) wherein Q represents Q1, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound class SX307).

[1252] A compound (2F) wherein Q represents Q1, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound class SX308).

[1253] A compound (2F) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound class SX309) .

[1254] A compound (2F) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound class SX310) .

[1255] A compound (2F) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound class SX311).

[1256] A compound (2F) wherein Q represents Q2, L represents an oxygen atom, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound class SX312) .

[1257] A compound (2F) wherein Q represents Q2, L represents NH, R.sup.22 represents a methyl group, R.sup.23 represents a hydrogen atom, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound class SX313).

[1258] A compound (2F) wherein Q represents Q2, L represents NH, R.sup.22 represents a chlorine atom, R.sup.23 represents a hydrogen atom, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound class SX314).

[1259] A compound (2F) wherein Q represents Q2, L represents NH, R.sup.22 represents a hydrogen atom, R.sup.23 represents a methyl group, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound class SX315).

[1260] A compound (2F) wherein Q represents Q2, L represents NH, R.sup.22 represents a hydrogen atom, R.sup.23 represents a chlorine atom, and R.sup.6 represents any substituents selected from Group Y (hereinafter, referred to as Compound class SX316).

[1261] Next, the formulation examples of the compounds of the present invention are shown below. In the formulation examples, the “parts” represents “part by weight” unless otherwise specified. The compound S of the present invention represents the compounds described in the Compound Classes SX1 to SX316.

[1262] Formulation Example 1

[1263] Fifty parts of any one of the compound S of the present invention, 3 parts of calcium lignin sulfonate, 2 parts of Magnesium lauryl sulfate, and 45 parts of synthetic hydrated silicon dioxide are well mixed-grinding to obtain a formulation.

Formulation Example 2

[1264] Twenty (20) parts of any one of the compound S of the present invention, 1.5 parts of sorbitan trioleate are mixed with 28.5 parts of an aqueous solution containing 2 parts of polyvinyl alcohol, and the mixture is then finely-ground by a wet grinding method. To the mixture is then added 40 parts of an aqueous solution containing 0.05 parts of xanthan gum and 0.1 parts of magnesium aluminum silicate, and 10 parts of propylene glycol is further added thereto. The mixture is stirred to obtain a formulation.

Formulation Example 3

[1265] Two(2) parts of any one of the compound S of the present invention, 88 parts of kaolin clay and 10 parts of talc are mixed-grinding to obtain a formulation.

Formulation Example 4

[1266] Five (5) parts of any one of the compound S of the present invention, 14 parts of polyoxyethylene styryl phenyl ether, 6 parts of calcium dodecylbenzene sulfonate and 75 parts of xylene are well mixed to obtain a formulation.

Formulation Example 5

[1267] Two(2) parts of any one of the compound S of the present invention, 1 part of synthetic hydrated silicon dioxide, 2 parts of calcium lignin sulfonate, 30 parts of bentonite and 65 parts of kaolin clay are mixed-grinding, and thereto is added water, and the mixture is well kneaded and is then granulated and dried to obtain a formulation.

Formulation Example 6

[1268] Twenty (20) parts of the present compound S, 35 parts of a mixture of white carbon and ammonium polyoxyethylene alkyl ether sulfate (weight ratio is 1:1) and appropriate amount of water is mixed to make the total amount thereof 100 parts, and the mixture is then finely-ground with a grinder to obtain a formulation.

[1269] Next, Test Examples are described.

[1270] The untreated groups in Test Example 1 to Test Exmaple 8 represent tested groups in which the same conditions as those of each of the Test Examples were conducted except that DMSO was dispensed in the place of a DMSO diluted solution comprising the compound of the present invention. Also the untreated groups in Test Exmaple 9 to Test Exmaple 20 represent tested groups in which an aqueous diluted solution of a formulation comprising the compound of the present invention is not applied. The untreated groups in Test Example 21 and Test Example 25 represent tested groups in which the same conditions as those of each of the Test Examples were conducted except that no test compounds are used.

Test Example 1: Control Test Against Wheat Septoria Leaf Blotch Fungus (Septoria Tritici)

[1271] The compound of the present invention, that is, compound No. 1-2, 1-3, 1-4, 1-5, 1-6, 1-7, 2-1, 2-2, 2-3, 2-4, 2-5, 2-6, 2-7, 2-8, 2-9, 2-10, 2-11, 2-12, 2-13, 2-14, 2-15, 2-16, 2-17, 2-18, 2-19, 3-1, 3-2, 3-3, 3-4, 3-5, 3-6, 3-7, 3-8, 3-9, 4-1, 4-2, 4-3, 4-4, 4-5, 4-6, 4-7, 4-8, 5-1, 5-2, 5-3, 5-4, 5-5, 5-7, 5-8, 5-10, 5-11, 5-12, 5-13, 5-14, 5-15, 5-16, 5-18, 5-19, 6-1, 6-2, 6-3, 6-5, 6-6, 6-7, 6-8, 7-1, 8-1, 8-2, 8-3, 8-4, 8-5, 8-6, 8-7, 9-1, 9-2, 9-3, 9-4, 9-5, 10-1, 10-2, 10-3, 1-1, 1-8, 1-13, 2-25, 2-26, 2-27, 2-32, 2-33, 2-34, 2-35, 2-36, 2-37, 2-39, 2-41, 2-42, 8-8, 8-9, 8-10, 8-11, 8-12, 8-13, 8-14, 8-15, 8-16, 8-17, 8-18, 8-19, 8-20, 8-21, 9-6, or 10-5 was diluted with DMSO so as to contain 150 ppm, and 1 .Math.L of the dilution solutions were dispensed into titer plate (96 well), and thereafter, thereto was then dispensed 150 .Math.L of a potato dextrose broth (PDB broth) to which conidia of Septoria tritici were inoculated in advance. This plate was cultured at 18° C. for 5 days, thereby allowing Septoria tritici to undergo proliferation, and the absorbance at 550 nm of each well of the titer plate was then measured to determine a degree of growth of Septoria tritici. As a result, every of the growth in the well in treated groups treated with each of the compounds of the present invention showed 50% or less compared to the growth in an untreated well.

Test Example 2: Control Test Against Cucurbitaceae Phytophthora Rot Fungus (Phytophthora Capsici)

[1272] The compound of the present invention, that is, compound No. 1-2, 1-3, 2-6, 2-11, 3-1, 3-4, 6-3, 8-4, 8-12, 8-21, 9-1, or 10-5 was diluted with DMSO so as to contain 150 ppm, and 1 .Math.L of the dilution solutions were dispensed into titer plate (96 well), and thereafter, thereto was then dispensed 150 .Math.L of a potato dextrose broth (PDB broth) to which spores of Phytophthora capsici were inoculated in advance. This plate was cultured at 27° C. for 3 days, thereby allowing Phytophthora capsici to undergo proliferation, and the absorbance at 550 nm of each well of the titer plate was then measured to determine a degree of growth of the Phytophthora capsici. As a result, every of the growth in the well in treated groups treated with each of the compounds of the present invention showed 50% or less compared to the growth in an untreated well.

Test Example 3: Control Test Against Seedling Blight Fungus (Pythium Ultimum)

[1273] The compound of the present invention, that is, compound No. 1-2, 1-3, 2-3, 2-7, 2-8, 2-9, 2-10, 2-13, 2-15, 2-17, 3-1, 3-4, 6-3, 8-1, 8-4, 9-1, 1-1, 2-25, 2-26, 2-33, 8-9, 8-11, 8-12, 8-14, 8-17, 8-18, or 10-5 was diluted with DMSO so as to contain 150 ppm, and 1 .Math.L of the dilution solutions were dispensed into titer plate (96 well), and thereafter, thereto was then dispensed 150 .Math.L of a potato dextrose broth (PDB broth) to which spores of Pythium ultimum were inoculated in advance. This plate was cultured at 23° C. for 5 days, thereby allowing Pythium ultimum to undergo proliferation, and the absorbance at 550 nm of each well of the titer plate was then measured to determine a degree of growth of the Pythium ultimum. As a result, every of the growth in the well in treated groups treated with each of the compounds of the present invention showed 50% or less compared to the growth in an untreated well.

Test Example 4: Control Test Against Corn Smut Fungus (Ustilago Maydis)

[1274] The compound of the present invention, that is, compound No. 1-2, 2-3, 2-4, 2-5, 2-6, 2-7, 2-8, 2-9, 2-10, 2-11, 2-12, 2-13, 2-14, 2-15, 2-17, 3-1, 3-4, 8-1, 1-1, 1-8, 2-25, 2-26, 2-27, 2-33, 2-34, 2-35, 2-36, 2-37, 2-39, 2-41, 2-42, 8-8, 8-9, 8-11, 8-12, 8-13, 8-14, 8-16, 8-17, 8-18, 10-5, or 2-32 was diluted with DMSO so as to contain 150 ppm, and 1 .Math.L of the dilution solutions were dispensed into titer plate (96 well), and thereafter, thereto was then dispensed 150 .Math.L of a potato dextrose broth (PDB broth) to which conidia of Ustilago maydis were inoculated in advance. This plate was cultured at 18° C. for 4 days, thereby allowing Ustilago maydis to undergo proliferation, and the absorbance at 550 nm of each well of the titer plate was then measured to determine a degree of growth of the Ustilago maydis. As a result, every of the growth in the well in treated groups treated with each of the compounds of the present invention showed 50% or less compared to the growth in an untreated well.

Test Example 5: Control Test Against Barley Scald Fungus (Rhynchosporium Secalis)

[1275] The compound of the present invention, that is, compound No. 1-2, 1-3, 2-2, 2-3, 2-4, 2-5, 2-6, 2-7, 2-8, 2-9, 2-10, 2-11, 2-12, 2-13, 2-14, 2-15, 2-16, 2-17, 3-1, 3-4, 3-6, 3-7, 6-2, 6-3, 6-4, 6-5, 7-1, 8-1, 8-2, 8-3, 8-4, 9-1, 1-1, 1-8, 1-9, 1-10, 1-11, 1-12, 1-13, 2-25, 2-26, 2-27, 2-32, 2-33, 2-34, 2-35, 2-36, 2-37, 2-38, 2-39, 2-40, 2-41, 2-42, 8-8, 8-9, 8-10, 8-11, 8-12, 8-13, 8-14, 8-15, 8-16, 8-17, 8-18, 8-19, 8-20, 8-21, 9-6, 10-5, or 11-3 was diluted with DMSO so as to contain 150 ppm, and 1 .Math.L of the dilution solutions were dispensed into titer plate (96 well), and thereafter, thereto was then dispensed 150 .Math.L of a potato dextrose broth (PDB broth) to which conidia of Rhynchosporium secalis were inoculated in advance. This plate was cultured at 18° C. for 7 days, thereby allowing Rhynchosporium secalis to undergo proliferation, and the absorbance at 550 nm of each well of the titer plate was then measured to determine a degree of growth of the Rhynchosporium secalis. As a result, every of the growth in the well in treated groups treated with each of the compounds of the present invention showed 50% or less compared to the growth in an untreated well.

Test Example 6: Control Test Against Cucumber Botrytis Rot Fungus (Botrytis Cinerea)

[1276] The compound of the present invention, that is, compound No. 1-2, 1-3, 2-2, 2-3, 2-4, 2-5, 2-6, 2-7, 2-8, 2-9, 2-10, 2-11, 2-12, 2-13, 2-14, 2-15, 2-16, 2-17, 3-1, 3-4, 3-6, 3-7, 6-2, 6-3, 6-4, 6-5, 7-1, 8-1, 8-2, 8-3, 8-4, 9-1, 1-1, 1-8, 1-9, 1-10, 1-12, 1-13, 2-25, 2-26, 2-27, 2-32, 2-33, 2-34, 2-35, 2-36, 2-37, 2-39, 2-40, 2-41, 2-42, 8-8, 8-9, 8-10, 8-11, 8-12, 8-13, 8-14, 8-15, 8-16, 8-17, 8-18, 8-19, 8-20, 8-21, 9-6, 10-5, or 11-3 was diluted with DMSO so as to contain 150 ppm, and 1 .Math.L of the dilution solutions were dispensed into titer plate (96 well), and thereafter, thereto was then dispensed 150 .Math.L of a potato dextrose broth (PDB broth) to which conidia of Botrytis cinerea were inoculated in advance. This plate was cultured at 18° C. for 4 days, thereby allowing Botrytis cinerea to undergo proliferation, and the absorbance at 550 nm of each well of the titer plate was then measured to determine a degree of growth of the Botrytis cinerea. As a result, every of the growth in the well in treated groups treated with each of the compounds of the present invention showed 50% or less compared to the growth in an untreated well.

Test Example 7: Control Test Against Peach Scab Fungus (Cladosporium Carpophilum)

[1277] The compound of the present invention, that is, compound No. 1-2, 1-3, 2-2, 2-3, 2-4, 2-5, 2-6, 2-7, 2-8, 2-9, 2-10, 2-11, 2-12, 2-13, 2-14, 2-15, 2-16, 2-17, 3-1, 3-4, 3-6, 3-7, 6-2, 6-3, 6-5, 7-1, 8-1, 8-2, 8-3, 8-4, 9-1, 1-1, 1-8, 1-10, 1-11, 1-12, 1-13, 2-25, 2-26, 2-27, 2-32, 2-33, 2-34, 2-35, 2-36, 2-37, 2-39, 2-40, 2-41, 2-42, 8-8, 8-9, 8-10, 8-11, 8-12, 8-13, 8-14, 8-15, 8-16, 8-17, 8-18, 8-19, 8-20, 8-21, 9-6, or 10-5 was diluted with DMSO so as to contain 150 ppm, and 1 .Math.L of the dilution solutions were dispensed into titer plate (96 well), and thereafter, thereto was then dispensed 150 .Math.L of a potato dextrose broth (PDB broth) to which conidia of Cladosporium carpophilum were inoculated in advance. This plate was cultured at 18° C. for 5 days, thereby allowing Cladosporium carpophilum to undergo proliferation, and the absorbance at 550 nm of each well of the titer plate was then measured to determine a degree of growth of the Cladosporium carpophilum. As a result, every of the growth in the well in treated groups treated with each of the compounds of the present invention showed 50% or less compared to the growth in an untreated well.

Test Example 8: Control Test Against Rice Brown Spot Fungus (Cochliobolus Miyabeanus)

[1278] The compound of the present invention, that is, compound No. 1-2, 1-3, 2-2, 2-3, 2-4, 2-5, 2-6, 2-7, 2-8, 2-9, 2-10, 2-11, 2-12, 2-13, 2-14, 2-15, 2-16, 2-17, 3-1, 3-4, 3-6, 3-7, 6-1, 6-2, 6-3, 6-4, 6-5, 7-1, 8-1, 8-2, 8-3, 8-4, 9-1, 1-1, 1-8, 1-9, 1-10, 1-11, 1-12, 1-13, 2-25, 2-26, 2-27, 2-32, 2-33, 2-34, 2-35, 2-36, 2-37, 2-38, 2-39, 2-40, 2-41, 2-42, 8-8, 8-9, 8-10, 8-11, 8-12, 8-13, 8-14, 8-15, 8-16, 8-17, 8-18, 8-19, 8-20, 8-21, 9-6, 10-5, or 11-3 was diluted with DMSO so as to contain 150 ppm, and 1 .Math.L of the dilution solutions were dispensed into titer plate (96 well), and thereafter, thereto was then dispensed 150 .Math.L of a potato dextrose broth (PDB broth) to which conidia of Cochliobolus miyabeanus were inoculated in advance. This plate was cultured at 23° C. for 3 days, thereby allowing Cochliobolus miyabeanus to undergo proliferation, and the absorbance at 550 nm of each well of the titer plate was then measured to determine a degree of growth of the Cochliobolus miyabeanus. As a result, every of the growth in the well in treated groups treated with each of the compounds of the present invention showed 50% or less compared to the growth in an untreated well.

Test Example 9: Control Test Against Soybean Rust (Phakopsora Pachyrhizi)

[1279] Soybean leaf (cv; Kurosengoku) was punched out to 1 cm diameter to prepare a leaf disk. Each 1 mL of an agar medium (agar concentration 1.2 %) was dispensed in each well of 24 well microplate. A piece of the leaf disk was placed on agar medium on each well. To a mixture of 0.5 .Math.L of Sorpol (registered trademark) 1200 KX, 4.5 .Math.L of DMSO, and 5 .Math.L of xylene was added 20 .Math.L of a solution containing 10000 ppm of the test compound in DMSO. The resulting mixture was diluted with ion exchange water to prepare a mixture containing a predetermined concentration of the test compound. The resulting mixture was sprayed in 10 .Math.L per one leaf disk. After 1 day, an aqueous suspension of conidia of Phakopsora pachyrhizi having an amino acid substitution of F129L on mitochondrial cytochrome b protein (1.0 × 10.sup.5 /mL) was inoculated onto the leaf disks. After the inoculation, the microplate was placed in a growth chamber (light on for 6 hours, light off for 18 hours, 23° C. temperature, 60 % humidity). After 1 day, the leaf disks were air-dried to disappear water droplets on the surface of the leaf disk, and the microplate was placed again in the growth chamber for 12 days. Thereafter, a lesion area of soybean rust disease was assessed. As a result, lesion areas in the leaf disk treated with any one of the compound of the present invention, that is, compound No. 1-2, 1-3, 2-1, 2-3, 2-4, 2-5, 2-6, 2-7, 2-8, 2-10, 2-11, 2-12, 2-13, 2-14, 2-15, 2-16, 2-17, 2-18, 3-1, 3-4, 3-6, 3-7, 3-8, 4-1, 4-2, 4-3, 4-4, 4-5, 4-6, 5-5, 5-8, 5-10, 5-11, 6-1, 6-2, 6-3, 6-4, 6-5, 6-6, 6-7, 6-8, 7-1, 8-1, 8-2, 8-3, 8-4, 8-6, 8-7, 9-1, 9-2, 9-3, 9-4, 9-5, 10-1, 10-2, 10-3, 1-1, 1-8, 1-10, 1-11, 1-13, 2-25, 2-26, 2-27, 2-32, 2-33, 2-34, 2-35, 2-37, 2-38, 2-39, 2-42, 2-43, 8-8, 8-9, 8-10, 8-11, 8-12, 8-13, 8-14, 8-15, 8-16, 8-17, 8-18, 8-19, 8-20, 8-21, or 10-5 as a tested compound at a prescribed concentration of 50 ppm showed 30% or more compared to the lesion areas in an untreated leaf disk.

Test Example 10: Control Test Against Rice Blast (Pyricularia Oryzae)

[1280] Each of plastic pots was filled with soil and thereto rice (cv; HINOHIKARI) seeds were sown and the plants were grown in a greenhouse for 20 days. Thereafter, the compound of the present invention, that is, compound No. 2-9, or 2-15, each of which was made to a formulation according to the similar method to that of Formulation Example 6, was mixed with water so as to be 200 ppm. The mixtures were sprayed to foliar parts so as to adhere adequately on the leaves of the above-mentioned rice. After spraying the mixtures, the rices were air-dried and were placed at 24° C. during daytime and 20° C. during nighttime under a high humidity for 6 to 7 days while the above-mentioned spraying-treated rice were contacted rice seedlings (cv; Hinohikari) infected by Pyricularia oryzae, and a lesion area was observed. As a result, every of the lesion areas in rice treated with each of the compounds of the present invention showed 30% or less compared to the lesion are in an untreated rice.

Test Example 11: Control Test Against Barley Net Blotch (Pyrenophora Teres)

[1281] Each of plastic pots was filled with soil and thereto barley (cv; NISHINOHOSHI) seeds were sown and the barleys were grown in a greenhouse for 7 days. Thereafter, the compound of the present invention, that is, compound No. 1-3, 2-3, 2-4, 2-5, 2-6, 2-7, 2-8, 2-9, 2-10, 2-11, 2-12, 2-13, 2-14, 2-15, 2-16, 2-17, 3-1, 3-4, 3-6, 3-7, 6-1, 6-2, 6-5, 7-1, 8-1, 8-2, 8-3, 9-1, 2-25, 2-26, 2-27, 2-32, 2-37, 2-39, 8-8, 8-9, 8-18, 8-19, 8-20, 10-5, 11-1, 11-2, or 11-3, each of which was made to a formulation according to the similar method to that of Formulation Example 6, was mixed with water so as to be a prescribed concentration (200 ppm). The resulting mixtures were sprayed to foliar parts so as to adhere adequately on the leaves of the above-mentioned barley. After spraying the mixtures, the barleys were air-dried and after 1 day, an aqueous suspension of the conidia of Pyrenophora teres was spraying-inoculated. After the inoculation, the barleys were placed at 23° C. during daytime and 20° C. during nighttime under a high humidity for 3 day and then cultivated in a greenhouse for 7 days, and a lesion area was observed. As a result, every of the lesion areas in barleys treated with each of the compounds of the present invention showed 30% or less compared to the lesion area in an untreated barley.

Test Example 12: Control Test Against Wheat Brown Rust (Puccinia Recondita)

[1282] Each of plastic pots was filled with soil and thereto wheat (cv; SHIROGANE) seeds were sown and the wheats were grown in a greenhouse for 9 days. The compound of the present invention, that is, compound No. 1-2, 2-3, 2-4, 2-5, 2-6, 2-7, 2-8, 2-10, 2-11, 2-12, 2-13, 2-14, 2-15, 2-16, 2-17, 3-1, 3-4, 3-6, 3-7, 6-1, 6-2, 6-3, 7-1, 8-1, 8-2, 8-3, 8-6, 9-1, 1-1, 2-27, 2-36, 2-37, 8-8, 8-9, 8-11, 8-12, 8-13, 8-14, 8-15, 8-16, 8-17, 8-18, 8-21, 9-6, or 10-5, each of which was made to a formulation according to the similar method to that of Formulation Example 6, was mixed with water so as to be 200 ppm, and the mixtures were sprayed to foliar parts so as to adhere adequately on the leaves of the above-mentioned wheat. After spraying the mixtures, the wheats were air-dried and were then cultivated at 20° C. under lighting for 5 to 7 days. The conidia of Puccinia recondita were sprinkling-inoculated. After the inoculation, the wheats were placed under a dark and humid condition at 23° C. for 1 day and were then cultivated at 20° C. under lighting for 8 days, and a lesion area was observed. As a result, every of the lesion areas in wheats treated with each of the compounds of the present invention showed 30% or less compared to the lesion area in an untreated wheat.

Test Example 13: Control Test Against Septoria Leaf Blotch (Septoria Tritici)

[1283] Each of plastic pots was filled with soil and thereto wheat (cv; Apogee) seeds were sown and the wheats were grown in a greenhouse for 10 days. Thereafter, the compound of the present invention, that is, compound No. 1-2, 1-3, 2-2, 2-3, 2-4, 2-5, 2-7, 2-8, 2-9, 2-10, 2-11, 2-12, 2-14, 2-15, 2-16, 2-17, 3-1, 3-4, 3-6, 3-7, 6-1, 6-3, 6-5, 7-1, 8-1, 8-2, 8-3, 8-4, 8-6, 8-7, 9-1, 1-11, 1-13, 2-25, 2-26, 2-27, 2-32, 2-33, 2-34, 8-8, 8-9, 8-11, 8-12, 8-13, 8-14, 8-15, 8-16, 8-17, 8-18, 8-19, 8-21, 9-6, 10-5, 10-6, 11-1, or 11-2, each of which was made to a formulation according to the similar method to that of Formulation Example 6, was mixed with water so as to be 200 ppm. The mixtures were sprayed to foliar parts so as to adhere adequately on the leaves of the above-mentioned wheat. After spraying the mixtures, the wheats were air-dried and after 4 days, an aqueous suspension of the conidia of Septoria tritici was spraying-inoculated. After the inoculation, the wheats were placed at 18° C. under a high humidity for 3 days and then under lighting for 14 to 18 days, and a lesion area was observed. As a result, every of the lesion areas in wheats treated with each of the compounds of the present invention showed 30% or less compared to the lesion area in an untreated wheat.

Test Example 14: Control Test Against Septoria Leaf Blotch (Septoria Tritici)

[1284] Each of plastic pots was filled with soil and thereto wheat (cv; Apogee) seeds were sown and the wheats were grown in a greenhouse for 10 days, and an aqueous suspension containing the conidia of Septoria tritici was spraying-inoculated. After the inoculation, the wheats were placed at 18° C. under a high humidity for 3 days, and thereafter, the compound of the present invention, that is, compound No. 1-2, 1-3, 2-3, 2-4, 2-5, 2-7, 2-8, 2-10, 2-11, 2-12, 2-13, 2-14, 2-15, 2-16, 2-17, 3-1, 3-4, 3-6, 3-7, 6-1, 6-5, 8-1, 8-2, 8-3, 8-4, 8-6, 8-7, 9-1, 2-25, 2-26, 2-27, 2-32, 2-33, 2-34, 2-36, 8-8, 8-9, 8-10, 8-11, 8-12, 8-13, 8-14, 8-15, 8-16, 8-17, 8-18, 8-19, 8-20, 8-21, 9-6, 10-5, or 11-1, each of which was made to a formulation according to the similar method to that of Formulation Example 6, was mixed with water so as to be 200 ppm. The mixtures were sprayed to foliar parts so as to adhere adequately on the leaves of the above-mentioned wheat. After spraying the mixtures, the wheats were air-dried and were placed under lighting for 14 to 18 days, and a lesion area was observed. As a result, every of the lesion areas in wheats treated with each of the compounds of the present invention showed 30% or less compared to the lesion area in an untreated wheat.

Test Example 15: Control Test Against Tomato Late Blight (Phytophthora Infestans)

[1285] Each of plastic pots was filled with soils and thereto tomato (cv; PATIO) seeds were sown and the tomatoes were grown in a greenhouse for 20 days. Thereafter, the compound of the present invention, that is, compound No. 1-3, 1-13, 2-4, 2-7, 2-8, 2-10, 2-12, 2-13, 2-16, 3-1, 3-4, 6-2, 8-9, 9-1, or 11-3, each of which was made to a formulation according to the similar method to that of Formulation Example 6, was mixed with water so as to be 200 ppm. The mixtures were sprayed to foliar parts so as to adhere adequately on the leaves of the above-mentioned tomato. After spraying the mixtures, the tomatoes were air-dried and after 1 day, an aqueous suspension of the spores of Phytophthora infestans were spraying-inoculated. After the inoculation, the tomatoes were placed in a greenhouse of 23° C. during daytime and 20° C. during nighttime under a high humidity for 1 day, and a lesion area was observed. As a result, every of the lesion areas in tomatoes treated with each of the compounds of the present invention showed 30% or less compared to the lesion area in an untreated tomato.

Test Example 16: Control Test Against Soybean Rust (Phakopsora Pachyrhizi)

[1286] Each of plastic pots was filled with soil and thereto soybean (cv: Kurosengoku) seeds were sown and the soybeans were grown in a greenhouse for 10 to 14 days. Thereafter, the compound of the present invention, that is, compound No. 1-2, 1-3, 2-3, 2-4, 2-5, 2-6, 2-7, 2-8, 2-10, 2-11, 2-12, 2-13, 2-14, 2-15, 2-16, 2-17, 3-1, 3-4, 3-6, 3-7, 6-1, 6-2, 6-3, 6-4, 8-1, 8-2, 8-3, 8-4, 8-6, 8-7, 9-1, 1-1, 1-13, 2-25, 2-26, 2-27, 2-32, 2-33, 2-34, 2-35, 2-39, 2-40, 8-8, 8-9, 8-10, 8-11, 8-12, 8-13, 8-14, 8-15, 8-16, 8-17, 8-18, 8-19, 8-20, 8-21, 9-6, or 10-5, each of which was made to a formulation according to the similar method to that of Formulation Example 6, was mixed with water so as to be 200 ppm. The resulting mixtures were sprayed to foliar parts so as to adhere adequately on the leaves of the above-mentioned soybean. After spraying the mixtures, the soybeans were air-dried and after 2 to 5 days, an aqueous suspension of the conidia of Phakopsora pachyrhizi was spraying-inoculated. After the inoculation, the soybeans were placed in a greenhouse of 23° C. during daytime and 20° C. during nighttime under a high humidity for 1 to 2 days, and were then cultivated in the greenhouse for 12 days, and a lesion area was observed. As a result, every of the lesion areas in soybean treated with each of the compounds of the present invention showed 30% or less compared to the lesion area in an untreated soybean.

Test Example 17: Control Test Against Soybean Rust (Phakopsora Pachyrhizi)

[1287] Each of plastic pots was filled with soil and thereto soybean (cv: Kurosengoku) seeds were sown and the soybeans were grown in a greenhouse for 10 days, and an aqueous suspension containing the conidia of Phakopsora pachyrhizi was spraying-inoculated. After the inoculation, the soybeans were placed in a greenhouse of 23° C. during daytime and 20° C. during nighttime under a high humidity for 1 day, and were then cultivated in the greenhouse for 1 to 2 days, and thereafter, the compound of the present invention, that is, compound No. 1-3, 2-3, 2-4, 2-5, 2-7, 2-8, 2-10, 2-11, 2-12, 2-13, 2-14, 2-15, 2-17, 3-1, 3-4, 3-6, 3-7, 6-1, 6-3, 6-4, 8-1, 8-3, 8-4, 8-6, 8-7, 9-1, 1-13, 2-25, 2-26, 2-27, 2-32, 2-33, 2-34, 2-35, 8-8, 8-9, 8-10, 8-11, 8-12, 8-13, 8-14, 8-15, 8-16, 8-17, 8-19, 8-21, or 10-5, each of which was made to a formulation according to the similar method to that of Formulation Example 6, was mixed with water so as to be 200 ppm, and the resulting mixtures were sprayed to foliar parts so as to adhere adequately on the leaves of the above-mentioned soybean. After spraying the mixtures, the soybeans were air-dried and cultivated in a greenhouse for 8 days, and a lesion area was then observed. As a result, every of the lesion areas in soybean treated with each of the compounds of the present invention showed 30% or less compared to the lesion area in an untreated soybean.

Test Example 18: Control Test Against Soybean Leaf Spot (Cercospora Sojina)

[1288] Each of plastic pots was filled with soil and thereto soybean (cv: Tachinagawa) seeds were sown and the soybeans were grown in a greenhouse for 13 days. Thereafter, the compound of the present invention, that is, compound No. 2-3, 2-4, 2-5, 2-6, 2-7, 2-8, 2-9, 2-10, 2-12, 2-13, 2-15, 2-16, 2-17, 3-1, 3-4, 3-6, 3-7, 6-2, 6-5, 7-1, 8-1, 9-1, 1-13, 2-27, 8-10, 8-11, 8-12, 8-13, 8-14, 8-15, 8-16, 8-17, 8-18, 8-19, 8-20, 8-21, 9-6, or 10-5, each of which was made to a formulation according to the similar method to that of Formulation Example 6, was mixed with water so as to be 200 ppm. The resulting mixtures were sprayed to foliar parts so as to adhere adequately on the leaves of the above-mentioned soybean. After spraying the mixtures, the soybeans were air-dried and after 1 day, an aqueous suspension of the conidia of Cercospora sojina was spraying-inoculated. After the inoculation, the soybeans were placed in a greenhouse of 23° C. during daytime and 20° C. during nighttime under a high humidity for 3 days, and were then cultivated in the greenhouse for 16 days, and a lesion area was observed. As a result, every of the lesion areas in soybean treated with each of the compounds of the present invention showed 30% or less compared to the lesion area in an untreated soybean.

Test Example 19: Control Test Against Tomato Early Blight (Alternaria Solani)

[1289] Each of plastic pots was filled with soils and thereto tomato (cv; PATIO) seeds were sown and the tomatoes were grown in a greenhouse for 20 days. Thereafter, the compound of the present invention, that is, compound No. 2-2, 2-4, 2-5, 2-8, 2-13, 2-15, 2-16, 2-17, 3-1, 3-4, 3-6, 6-2, 6-4, 6-5, 7-1, 1-11, 1-13, 2-36, 2-37, or 2-40, each of which was made to a formulation according to the similar method to that of Formulation Example 6, was mixed with water so as to be 200 ppm. The resulting mixtures were sprayed to foliar parts so as to adhere adequately on the leaves of the above-mentioned tomato. After spraying the mixtures, the tomatoes were air-dried and after 1 day, an aqueous suspension of the conidia of Alternaria solani were spraying-inoculated. After the inoculation, the tomatoes were placed at 18° C. under a high humidity for 6 days, and a lesion area was observed. As a result, every of the lesion areas in tomatoes treated with each of the compounds of the present invention showed 30% or less compared to the lesion area in an untreated tomato.

Test Example 20: Control Test Against Kidney Bean Stem Rot (Sclerotinia Sclerotiorum)

[1290] Each of plastic pots was filled with soil and thereto Kidney bean (cv; NAGAUZURA SAITO) seeds were sown and the kidney beans were grown in a greenhouse for 8 days. Thereafter, the compound of the present invention, that is, compound No. 1-2, 1-3, 2-3, 2-4, 2-5, 2-7, 2-8, 2-9, 2-10, 2-11, 2-13, 2-15, 3-1, 3-4, 6-3, 8-1, 8-2, 8-3, 8-6, 8-7, 2-27, 8-8, 8-9, 8-10, 8-12, 8-13, 8-14, 8-18, 8-21, 9-6, or 10-5, each of which was made to a formulation according to the similar method to that of Formulation Example 6, was mixed with water so as to be 200 ppm. The resulting mixtures were sprayed to the foliar parts so as to adhere adequately on the leaves of the above-mentioned kidney bean. After spraying the mixtures, the kidney beans were air-dried and a PDA medium containing hyphae of Sclerotinia sclerotiorum was placed on the leaves of the kidney bean. After the inoculation, all kidney beans were placed under a high humidity during only night and after 4 days, a lesion area was observed. As a result, every of the lesion areas in kidney beans treated with each of the compounds of the present invention showed 30% or less compared to the lesion area in an untreated kidney beans.

Test Method 21: Tests Against Cotton Aphids

[1291] The test compounds is made to a formulation according to a similar method to that described in the Formulation Example 6, and thereto is added water containing 0.03 v/v % of a spreader to prepare a diluted solution containing a prescribed concentration of the test compound.

[1292] Cucumber (Cucumis sativus) seedling (on the developmental stage of the second true leaf) is planted in a container and approximately 30 cotton aphids (Aphis gossypii) (all stages of life) are released onto the leaves of the cucumber. After 1 day, the diluted solutions are sprayed into the seedling in a ratio of 10 mL/seedling. Further, after 5 days, the number of the surviving insects is examined and the controlling value is calculated by the following equation.

[00001]$\text{Controlling}\text{value}\left(\%\right)=\left\{1-\left(\text{Cb}\times \text{Tai}\right)/\left(\text{Cai}\times \text{Tb}\right)\right\}\times 100$

wherein the symbols in the formula represent the following descriptions. [1293] Cb: Number of the test insects in untreated group; [1294] Cai: Number of the surviving insects at the time of the investigation in untreated group; [1295] Tb: Number of the test insects in treated group; [1296] Tai: Number of the surviving insects at the time of the investigation in treated group;

Test Example 21

[1297] The test was conducted by making the prescribed concentration 500 ppm and using the below-mentioned compounds of the present invention as a test compound according to the test method 21. As a result of the test, the below-mentioned compounds of the present invention showed 90 % or greater as the controlling value.

[1298] Compound of the present invention: 1-2, 8-3, 8-4, 9-1, and 2-41

Test Method 22: Tests Against Brown Planthoppers

[1299] The test compounds are made to a formulation according to a similar method to that described in the Formulation Example 6, and thereto is added water containing 0.03 v/v % of a spreader to prepare a diluted solution containing a prescribed concentration of the test compound.

[1300] Rice (Oryza sativa) seedling (on the developmental stage of the second true leaf) is planted in a container, and the diluted solutions are sprayed into the seedling in a ratio of 10 mL/seedling. Thereafter, 20 3rd instar larvae of brown planthoppers (Nilaparvata lugens) are released onto the rice leaves. After 6 days, the morality is calculated by the following equation.

[00002]$\begin{array}{l}\text{Morality}\left(\text{\%}\right)=\left\{\text{1}-\text{the}\text{number}\text{of}\text{the}\text{surviving}\right)\\ \text{insects}/\left(20\right\}\times 100\end{array}$

Test Example 22

[1301] The test was conducted by making the prescribed concentration 500 ppm and using the below-mentioned compounds of the present invention as a test compound according to the test method 22. As a result of the test, the below-mentioned compound of the present invention showed 90% or greater as the controlling value.

[1302] Compound of the present invention: 1-2, and 8-8

Test Method 23: Tests Against Cotton Worm

[1303] Test compounds are made to a formulation according to a similar method to that described in the Formulation example 6, and thereto is added water containing 0.03 v/v% of Shindain (registered trademark) to prepare a diluted solution containing a prescribed concentration of the test compound.

[1304] Cabbage (Brassicae oleracea) seedling (on the developmental stage of the second to third true leaf) is planted in a cup, and the diluted solutions are sprayed into the seedling at a ratio of 20 mL/seedling. Thereafter, the stem and leaf thereof is cut out and then is installed into a cup that is covered with filter paper on the bed of the cup. Five (5) cotton worm (Spodoptera litura) at the second instar larval stage are released into the cup. After 5 days, the number of the surviving insects is counted, and the mortality of insects is calculated by tne following equation.

[00003]$\begin{array}{l}\text{Mortality}\left(\text{\%}\right)\text{=}\left(1-\text{Number}\text{of}\text{surviving}\text{insects/5}\right)\times \\ 100\end{array}$

Test Example 23

[1305] The test was conducted by making the prescribed concentration 500 ppm and using the below-mentioned compounds of the present invention as a test compound according to the test method 23. As a result of the test, the below-mentioned compound of the present invention showed 80 % or greater as the mortality of insects.

[1306] Compound of the present invention: 1-2, and 8-4

Test Method 24: Tests Against Diamondback Moth

[1307] Test compounds are made to a formulation according to a similar method to that described in the Formulation example 6, and thereto is added water containing 0.03 v/v% of Shindain (registered trademark) to prepare a diluted solution containing a prescribed concentration of the test compound.

[1308] Cabbage (Brassicae oleracea) seedling (on the developmental stage of the second to third true leaf) is planted in a cup, and the diluted solutions are sprayed into the seedling at a ratio of 20 mL/seedling. Thereafter, the stem and leaf thereof is cut out and then is installed into a cup that is covered with filter paper on the bed of the cup. Five (5) diamondback moth (Plutella xylostella) at the second instar larval stage are released into the cup. After 5 days, the number of the surviving insects is counted, and the mortality of insects is calculated by the following equation.

[00004]$\begin{array}{l}\text{Morality}\left(\text{\%}\right)\text{=}\left(1-\text{Number}\text{of}\text{surviving}\text{insects}/5\right)\times \\ 100\end{array}$

Test Example 24

[1309] The test was conducted by making the prescribed concentration 500 ppm and using the below-mentioned compounds of the present invention as a test compound according to the test method 24. As a result of the test, the below-mentioned compounds of the present invention showed 80% or greater as the mortality of insects.

[1310] Compound of the present invention: 1-2, 2-6, 8-3, 8-4, 1-1, 2-32, 8-8, and 8-9

Test Method 25: Tests Against Common Red Spider Mite

[1311] The test compounds is made to a formulation according to a similar method to that described in the Formulation Example 6, and thereto is added water containing 0.03 v/v % of a spreader to prepare a diluted solution containing a prescribed concentration of the test compound.

[1312] Kidney bean (Phaseolus vulgaris) seedling (on the developmental stage of the first true leaf) is planted in a container and approximately 40 adult female of common red spider mites (Tetranychus urticae) are released onto the leaves of the kidney bean. After 1 day, the diluted solutions are sprayed into the seedling in a ratio of 10 mL/seedling. Further, after 13 days, the number of the surviving insects is examined and the controlling value is calculated by the following equation.

[00005]$\text{Controlling}\text{value}\left(\%\right)=\left\{1-\left(\text{Cb}\times \text{Tai}\right)/\left(\text{Cai}\times \text{Tb}\right)\right\}\times 100$

wherein the symbols in the formula represent the following descriptions. [1313] Cb: Number of the test insects in untreated group; [1314] Cai: Number of the surviving insects at the time of the investigation in untreated group; [1315] Tb: Number of the test insects in treated group; [1316] Tai: Number of the surviving insects at the time of the investigation in treated group; [1317] Here the “untreated group” represents a group where the similar treatment procedure to that of the treated group except not using the test compound is done.

Test Example 25

[1318] The test was conducted by making the prescribed concentration 500 ppm and using the below-mentioned compounds of the present invention as a test compound according to the test method 25. As a result of the test, the below-mentioned compounds of the present invention showed 90% or greater as the controlling value.

[1319] Compound of the present invention: 1-2, 2-6, 8-2, 8-4, 9-1, 1-1, 1-8, 1-11, 1-12, 2-32, 2-33, 2-34, 2-41, and 8-21

Industrial Applicability

[1320] The compound of the present invention has efficacies for controlling pests and can be used to control pests.