System, process and apparatus to determine LINAC Isocenter

Abstract

A system to determine the isocenter of a LINAC includes apparatus and processes. One embodiment does this by determining the axis of rotation for the collimator, the gantry, and may include the couch. In another embodiment only determining the axis of the rotation of the collimator is required. The system and apparatus enable the tracking of the translation-rotation of mechanical components attached to the LINAC to compute the axis of rotation of gantry, collimator and couch. Based on the data collected related to these axes the LINAC isocenter is determined. The primary apparatus utilized in the system includes a single emitter module, a signal receiver module, and a positioning module. The system also includes an isocenter target module and a gravity module to determine a gravity vector relative to the signal receiver.

Claims

1. A LINAC mechanical isocenter determination process comprising: mounting a signal emitter module on a collimator; mounting a signal receiver module at a location with an unobstructed view of the signal emitter module; determining an axis of rotation for a gantry by rotating the gantry while the signal receiver module acquires signal emitter module positions; determining an axis of rotation for the collimator by rotating the collimator while the gantry is at a fixed position and the signal receiver module acquires signal emitter module positions during the collimator rotation; and determining the LINAC mechanical isocenter by processing signal emitter module positions during the collimator rotation and the gantry rotation.

2. A LINAC mechanical isocenter determination process according to claim 1, wherein the signal receiver module is mounted on a couch, further comprising determining an axis of rotation for the couch by rotating the couch while the signal receiver module acquires signal emitter module positions during the couch rotation and determining the LINAC mechanical isocenter by processing the signal emitter module positions for the axis of rotation for the gantry, the collimator, and the couch.

3. The LINAC mechanical isocenter determination process according to claim 1 wherein the signal emitter module emits light signals and the signal receiver module receives the light signals.

4. The LINAC mechanical isocenter determination process according to claim 3 wherein the signal emitter module comprises a minimum of one marker reflecting or emitting light at a specific frequency optimized for the signal receiver module.

5. The LINAC mechanical isocenter determination process according to claim 4 wherein the signal receiver module is a camera pod.

6. The LINAC mechanical isocenter determination process according to claim 5 wherein the camera pod is comprised of at least 2 cameras capable of acquiring time synchronized images for computer analysis.

7. The LINAC mechanical isocenter determination process according to claim 1 further comprising mounting an isocenter target module on a positioning module and positioning the isocenter target module at the LINAC isocenter using at least one emitter marker on the isocenter target module.

8. The LINAC mechanical isocenter determination process according to claim 7 wherein the isocenter target module includes a radiation opaque marker inside a target body.

9. The LINAC mechanical isocenter determination process according to claim 8 wherein the isocenter target module includes crosshairs on an outside of the target body.

10. The LINAC mechanical isocenter determination process according to claim 9 wherein the positioning module includes controls for an X position, a Y position, and a Z position.

11. The LINAC mechanical isocenter determination process according to claim 1 further comprising utilizing a processor to collect data and process it utilizing software.

12. A LINAC radiation isocenter determination process comprising: mounting a signal emitter module on a collimator; mounting a signal receiver module in a location with an unobstructed view of the signal emitter module; rotating the collimator with a gantry positioned at a first angle while the signal receiver module acquires signal emitter module positions; determining a calculated collimator axis of rotation from the signal emitter module positions acquired with the gantry positioned at the first angle; rotating the collimator with the gantry positioned at a second angle while the signal receiver module captures the signal emitter module positions; determining a calculated collimator axis of rotation from the signal emitter module positions acquired with the gantry positioned at the second angle; and determining LINAC radiation isocenter using the calculated collimator axis of rotation with the gantry positioned at the first angle and the calculated collimator axis of rotation with the gantry positioned at the second angle.

13. The LINAC radiation isocenter determination process according to claim 12 further comprising rotating the collimator with the gantry positioned at a minimum of one additional angle while the signal receiver module captures the signal emitter module positions.

14. The LINAC radiation isocenter determination process according to claim 12 wherein the signal emitter module emits light signals and the signal receiver module receives the light signals.

15. The LINAC radiation isocenter determination process according to claim 12 wherein the signal receiver module is mounted on a couch.

16. The LINAC radiation isocenter determination process according to claim 12 further comprising rotating a couch and determining LINAC radiation isocenter using the computed collimator and coach axes.

17. A LINAC collimator axis of rotation determination process comprising: mounting a signal emitter module on a collimator; mounting a signal receiver module at a location with an unobstructed view of the signal emitter module; and determining the collimator axis of rotation by rotating the collimator while the gantry is at a fixed position and the signal receiver module acquires signal emitter module positions.

18. A LINAC couch axis of rotation determination process comprising: mounting a signal emitter module on a couch; mounting a signal receiver module at a location with an unobstructed view of the signal emitter module; and determining the couch axis of rotation by rotating the couch while the signal receiver module acquires signal emitter module positions.

19. A gravity vector determination process comprising mounting a gravity module on a collimator; mounting a camera pod in a location with an unobstructed view of the gravity module; and using the camera pod to acquire images of a location of the gravity module to determine a direction of a gravity vector relative to an internal coordinate system of the camera pod.

20. A collimator axis walkout determination process comprising: mounting a signal emitter module on a collimator; mounting a signal receiver module at a location with an unobstructed view of the signal emitter module; rotating the collimator while the signal receiver module acquires signal emitter module positions; determining a path through space of the signal emitter module during the collimator rotation by analyzing the signal emitter module positions; fitting the computed signal emitter module positions to a three-dimensions circle in space; and computing an error vector between each position and a nearest point to the fit three-dimensional circle.

21. A couch axis walkout determination process comprising: mounting a signal emitter module on a collimator; mounting a signal receiver module at a location with an unobstructed view of the signal emitter module; determining a path through space of the signal emitter module during couch rotation by analyzing signal emitter module positions; fitting the computed signal emitter module positions to a three-dimensions circle in space; and computing an error vector between each position and a nearest point to the fit three-dimensional circle.

22. The gravity vector determination process of claim 19, wherein the gravity module comprises a pendulum wire configured to indicate the direction of the gravity vector.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) FIG. 1 depicts the gantry [1] rotation, the gantry axis of rotation [2], and the treatment couch [3].

(2) FIG. 2 depicts the collimator [4] rotation about the collimator axis of rotation [5].

(3) FIG. 3 depicts the couch [3] rotation about the couch axis of rotation [6].

(4) FIG. 4 depicts the isocenter [8] as the intersection of the gantry axis of rotation [3] and the collimator and couch axes of the rotation [5].

(5) FIG. 5 depicts the collimator mount [11] and the signal emitting module [12] mounted on the collimator mount (11) and the signal receiver module/camera pod [10]

(6) FIG. 6 depicts the signal emitting module [12] connected to the collimator [4] via the collimator mount [11]. The signal receiver module/camera pod [10] is shown in position for mounting on positioning module [22] attached to the patient treatment couch

(7) FIG. 7 depicts the signal emitting module [12] connected to the collimator mount [11] via a bayonet style mechanism (40) on both the collimator mount [38] and the signal emitting module [12].

(8) FIG. 8 depicts a side view of the signal emitting module [12] showing the spherical emitters [14].

(9) FIG. 9 depicts the camera pod showing the left camera [17], a right camera [18], and a mechanical interface [20] to positioning module [22].

(10) FIG. 10 depicts the positioning module [22] mechanically connecting the two components: isocenter target module [21] and camera pod [10]. Locating pins on the positioning module [23] and [24] ensure a robust and reproducible mechanical interface.

(11) FIG. 11 depicts the isocenter target module [21] seated within the positioning module [22]. The camera pod monitors the signal emitters [25] of the isocenter target module [22] in order to precisely position the target body [26] to isocenter.

(12) FIG. 12 depicts the isocenter target module [21] positioned beneath the gantry [1] within the radiation field. The camera pod [10] is positioned on the couch and tracks the position/orientation of the isocenter target module [21].

(13) FIG. 13 depicts the components of the positioning module [22]: Z adjustment knob of the positioning module [27], X adjustment knob of the positioning module [28], mechanical interface between positioning module and camera pod [23], Y adjustment knob of the positioning module [29], clamping knob [60], couch clamp [30], and mechanical interface between positioning module and isocenter target module [24].

(14) FIG. 14 depicts the components of the isocenter target module [21], rear view: signal emitters [25], target body [26], back plate [34], and extension neck [33].

(15) FIG. 15 depicts the components of the isocenter target module [21], front view: signal emitter for isocenter target module [25], target body of the isocenter target module [26], back plate of the isocenter target module [34], extension neck of the isocenter target module [33], crosshairs on the isocenter target module[35].

(16) FIG. 16 depicts a cross-section of the isocenter target module showing the radiation opaque marker [36] which is aligned with the external crosshairs [35] that are etched on the target body [26].

(17) FIG. 17 depicts the gravity detect module [37] mounted to the collimator mount [11] with bayonet style connections [39] and [38].

(18) FIG. 18 depicts the gravity detect module (gravity module) [37] in typical use configuration connected to the collimator mount [11]. The isocenter target module [21] is removed from the positioning module [22] so as not to interfere with the gravity module [37]. The camera pod [10] is positioned on the couch top [3] as it monitors the gravity module [37].

(19) FIG. 19 depicts the gravity detect module showing the pendulum wire [44], compartment for dampening fluid [46], high contrast background [47], and fluid release port [48].

(20) FIG. 20 depicts a cross-section view of the gravity detect module: pendulum wire [44], pendulum ball [45], compartment for dampening fluid [46], fluid release port [48], mounting location for pendulum string [49]

(21) FIG. 21 depicts the signal emitting module [12] with individual signal emitters [14], computed emitter centers [51] and computed emitter position/orientation [52].

(22) FIG. 22 depicts an example of six images captured by the camera pod [10] as the signal emitting module [12] rotates while connected the collimator mount [11].

(23) FIG. 23 depicts signal emitting positions/orientations computed from the positions of the signal emitting modules shown in FIG. 22.

(24) FIG. 24 depicts the found emitter vector heads [52] and the optimized fit [52] of the vector head. The normal to the optimized fit will produce the axis of rotation [2].

(25) FIG. 25 is an example of LINAC isocenter based on the gantry, collimator, and couch axes of rotation.

(26) FIG. 26 is an example of positional offset vector.

(27) FIG. 27 is an example of walkout radius determined from bounding sphere for all points of closest approach.

(28) FIG. 28 is a depiction of gravity vector [59] determined via the intersection of intersection of [57] and [58]: left camera image during gravity image determination [53], right camera image during gravity image determination [54], pendulum wire as seen from left camera [55], pendulum wire as seen from right camera [56], projection plane of left side pendulum wire from focal point of left camera [57], projection plane of right side pendulum wire from focal point of left camera [58].

(29) FIG. 29 depicts an example of a multi-axis rotational center (MARC) dataset. The MARC dataset captures the signal emitter positions for a series of collimator rotations measurements made under different fixed gantry angles. In this example, nine measurements were collimated. For each measurement (items [61], [62], and [63] for example) the collimator is fully rotated while the gantry remains at a fixed position. The center of rotation [64] and the axis of rotation [68] are computed for each collimator rotation.

(30) FIG. 30 depicts a two-dimensional orthogonal view of the example MARC dataset shown in FIG. 29. For each collimator rotation, the center of rotations [64] and the axis of rotations [65] are shown. A point in space which represents the center of a sphere [66], who's minimal radius encloses all of the axes of rotation can be computed. The center of this sphere is the radiation isocenter, while the radius of this sphere represents the radiation isocenter error.

PARTS LIST

(31) 1. Gantry. The main component of the LINAC which rotates about the patient when delivery radiation during radiation therapy. 2. Gantry axis of rotation. A mathematical construct that represents the axis about which the gantry rotates. 3. Patient Treatment Couch. Supports the patient during treatment. 4. Collimator. The end of the gantry closest to the patient. The collimator contains jaws which collimate the radiation beam. The collimator can rotate about its own axis to orient the jaws relative to the patient's treatment area. 5. Collimator axis of rotation. A mathematical construct that represents the axis about which the collimator rotates. 6. Couch Axis of rotation. A mathematical construct that represents the axis about which the couch rotates. 7. Not used. 8. Mechanical Isocenter. The intersection of the gantry, collimator and couch axes. 9. Not used. 10. Signal Receiving Module (Camera Pod). Acquires stereoscopic images and transmits the images to a computer for processing. 11. Collimator Mount. Mechanically connects the signal emitting module and the gravity module to the LINAC collimator. 12. Signal Emitting Module. Mechanically connects to the collimator and emits a signal during gantry, collimator, or couch rotation. These signals are processed by a computer to determine the mechanical axes or rotation of the gantry, collimator or couch. 13. Not used. 14. Signal Emitter. The individual signal emitter of the signal emitting module. These can be spherical or any other symmetrical or asymmetrical shape. These can emit optical light, infrared light, radiofrequency waves, or any signal that can used to determine the position and orientation of the module. 15. Not used. 16. Not used. 17. Left Camera. 18. Right Camera 19. Not used. 20. Mechanical Interface. Provides a mechanical connection point between the signal receiver and the positioning module. 21. Isocenter Target Module. Contains signal emitters precisely positioned relative to a radiation opaque marker. The emitters are tracked by the signal receiver so that the radiation opaque marker can be positioned with high accuracy to the found isocenter. 22. Positioning Module. Allows for precise manual adjustment of the isocenter target module's location in space. 23. Mechanical Interface between positioning module and Camera Signal Detector. Ensures that the mechanical connection between the isocenter target module and the signal receiver will be easy to reproduce. 24. Mechanical Interface between positioning module and isocenter target module. Ensures that the mechanical connection between the isocenter target module and the signal receiver will be easy to reproduce. 25. Signal Emitter for Isocenter Target Module. The individual signal emitter of the isocenter target module. These can emit optical light, infrared, radiofrequency or any signal that can used to determine the position and orientation of the signal emitting module. 26. Target Body of the Isocenter Target Module. Encapsulates the radiation opaque marker (typically a sphere of high-density metal such as tungsten). Contains crosshairs on the outer surface that are aligned with the sphere within. 27. Z adjustment Knob of the positioning module. Provides manual adjustment in the Z direction of the radiation opaque marker. 28. X adjustment Knob of the positioning module. Provides manual adjustment in the X direction of the radiation opaque marker. 29. Y adjustment Knob of the positioning module. Provides manual adjustment in the Y direction of the radiation opaque marker. 30. Couch Clamp. Connects the positioning module to the couch. 31. Not used 32. Not used 33. Extension Neck of the Isocenter Target Module 34. Back plate of the Isocenter Target Module. 35. Crosshairs on the Target Body of the Isocenter Target Module. Provide visual indication as to the location of the radiation opaque marker embedded within the target body. 36. Radiation Opaque Spherical Target. The spherical target is used to confirm that radiation is being focused properly to the found isocenter. The process of focusing radiation is not described here. This invention is only concerned with positioning the target to the correct location. 37. Gravity Detect Module. Allows for the detection of the direction of gravity. 38. Bayonet Style attachment mechanism of the collimator Mount 39. Bayonet Style attachment mechanism of the gravity module 40. Bayonet Style attachment mechanism of the SEP 41. Not used 42. Not used 43. Not used 44. Pendulum wire of the gravity module. Used as a indicator of the direction of gravity. Image processing techniques compute the wire direction. 45. Pendulum Ball of the gravity module. Ensures that the pendulum wire will be taught and aligned with the earth's gravitational field. 46. Compartment for dampening fluid of the gravity module. Gets filled with a viscous fluid (water) to dampen the oscillations of the pendulum wire. 47. High contrast background for pendulum wire. 48. Fluid release port. 49. Mounting location for pendulum string 50. Computed center of the emitter. The three-dimensions location, computed through image processing techniques, of the center of the individual emitter. The computer determines this position by combining the found center of the emitter in each left and right image, and then triangulating these positions into three-dimensions. 51. Found center of each individual emitter. 52. Head of the computed emitter vectors 53. Left camera image during gravity image determination. This is a depiction of the image sensor on the left camera. 54. Right camera image during gravity image determination. This is a depiction of the image sensor on the left camera. 55. Pendulum wire as seen from left camera [17]. This is pendulum wire as seen by the camera (projected onto the imaging sensor). 56. Pendulum wire as seen from right camera [18]. This is pendulum wire as seen by the camera (projected onto the imaging sensor). 57. Projection plane of left side pendulum wire. This is a mathematical construct. The focal point of left camera [17] and the pendulum wire on the image sensor creates a plane. 58. Projection plane of right-side pendulum wire. This is a mathematical construct. The focal point of left camera [17] and the pendulum wire on the image sensor creates a plane. 59. Gravity vector determination. Computed from the from intersection of previously computed plane [57] and plane [58]. This 60. Clamping Knob. Used to tighten the positioning module to the couch top. 61. A dataset of the acquired signal emitter positions while the collimator rotated through a fully 360° rotation while the gantry remained at a fixed angle of approximately position of −40 degrees. 62. A dataset of the acquired signal emitter positions while the collimator rotated through a fully 360° rotation while the gantry remained at a fixed angle of approximately position of 0 degrees. 63. A dataset of the acquired signal emitter positions while the collimator rotated through a fully 360° rotation while the gantry remained at a fixed angle of approximately position of +40 degrees. 64. The computed center of rotation of the dataset [63] acquired with gantry positioned at +40. 65. The computed axis of rotation of the dataset [63] acquired with gantry positioned at +40. 66. A MARC sphere computed from the data shown in FIG. 29. The MARC sphere is defined as the sphere with the smallest possible radius while still satisfying the requirement that each and every axis of rotation interests the sphere at least one point. The center of the MARC sphere is the radiation isocenter and the radius of the sphere represents the radiation isocenter error.

DETAILED DESCRIPTION

(32) The primary assemblies/components of the disclosed system are:

(33) Signal Emitting Module

(34) The signal emitting module shown on FIG. 8 contains spherical markers [14] in a fixed orientation. These spherical markers reflect or omit light at a frequency detectable by the camera pod's [10] detectors (FIG. 6). The signal emitting module rigidly mounts to the LINAC collimator via a collimator mount mechanism (item [11] in FIG. 6). Once mounted it will rotate with the gantry and collimator, acting as a trackable physical extension to them.

(35) Signal Receiver Module/Camera Pod

(36) The camera pod [10] (see FIG. 9) contains cameras encased in a rigid outer body in a known fixed orientation to each other. The camera pod acquires time-synchronized images and transmits those images to a computer/processor for analysis. With stereoscopic imaging processing techniques, the location and orientation of objects in real space can be determined from the object's found location within each image.

(37) The camera pod is positioned on the couch in direct view of the mounted signal emitting module (FIG. 6). This orientation allows for full visibility of the signal emitting module during gantry rotations (see FIG. 1), collimator rotations (see FIG. 2) and couch rotations (see FIG. 3).

(38) Positioning Module

(39) As shown in FIG. 10, the positioning module [22] is positioned in front of the couch. The positioning module [22], camera pod [10] and isocenter target module [21] are mechanically interfaced when attached to the couch, which fixes their relative positions to each other. It is not required that the position module be mounted to the couch. For example, a tripod or mounting brackets to the ceiling or floor, could be used just as effectively.

(40) The positioning module [22] provides a means for adjusting the position of the isocenter target module [21] relative to the camera pod [10]. It contains three manual adjustment knobs (items [27], [28] and [29] in FIG. 13) which independently adjust the isocenter target module in three cartesian directions.

(41) Isocenter Target Module

(42) The purpose of the isocenter target module [21] is to position a physical target to either the found isocenter location or a collimator axis of rotation, creating a real-world reference to locations previously only existing mathematically within computer/processor's software coordinate system. Once positioned at on a collimator axis of rotation, x-ray images of LINAC generated radiation beams passing through the target can be used to steer the LINAC's radiation to the center of the spherical target (resulting in an alignment the LINAC's radiation beam and the collimator axis of rotation). A similar process can be used when positioning the target to the radiation isocenter. In this case, x-ray images of LINAC radiation through the target as the gantry, collimator and couch rotate would then be an independent check of the position and size of the computed radiation isocenter. Crosshairs on the target body can then also be used to adjust the treatment room patient setup lasers so that they also align with the found isocenter. The isocenter target module ([21] in FIG. 11) is positioned on the positioning module [22]. It contains spherical emitting markers [25] in fixed known positions. The emitters are visible by the camera pod and are used to determine its position and orientation within the camera pods coordinate system. The spherical emitter locations are accurately fixed on the module relative the radiation opaque target (usually a high-density metal sphere) contained within target body [26].

(43) The target body [26], shown in cross-section on FIG. 16, contains an embedded radiation-opaque spherical target [36] aligned with external crosshairs on the outer surface [35]. The target body is shown as a rectangular rod with crosshairs on all or some of the sides. Other shapes could be used, such as, for example, a cylindrical tube shape with crosshairs spaced at 90° around the tube body.

(44) Gravity Detection Module

(45) The gravity module [37] (FIG. 18) connects to the collimator mount [11] in an identical manner and location as the signal emitting module so that it also can be imaged by the camera pod [10]. As can be seen in FIG. 19, it contains a plumb wire [44] that is visible by the camera pod through an opening in its outer casing. The plumb wire is held taught by a weight ([45] in FIG. 20) at its end and a vessel of fluid surrounding the weight dampens its oscillations (see cross-sectional view in FIG. 20).

(46) Determining the Radiation Isocenter (without couch considered) 1. A signal emitting module [12] is attached to the collimator [4] of a medical linear accelerator (LINAC) gantry via a collimator mount [11] as shown in FIG. 6. A signal receiver [10] is positioned on the LINAC couch [3] in a position to acquire stereoscopic images of the signal emitting module [12]. 2. The gantry is fixed at a given position (for example, at 0° facing down) while the collimator ([4] in FIG. 2) is mechanically rotated while the signal receiver [10] acquires image pairs of the signal emitting module [12] as it rotates. While a maximum rotation allowable by the LINAC is preferable for optimal results, partial rotations can also be use in cases where full rotations are not possible. 3. A software registration process is used to compute the orientation and location of the signal emitting module for each image pair acquired above (shown as [52] in FIG. 21). For each acquisition, left-right images pairs are sent from signal receiver [10] to a computer to determine the location and orientation of the signal emitting module in three-dimensions. To accomplish this, image process techniques locate the center of each individual emitter (see [51] in FIG. 21) in each image. Stereoscopic image process techniques then compute the three-dimensions coordinates of each individual signal emitter from its location in the left and right-sided images. The group of three-dimensional positions of all the individual signal emitters and then registering against the expected individual emitter locations to compute the module's location and orientation. 4. The gantry is then incremented either clockwise or counterclockwise (for example, 30° from the previous position). With the gantry fixed at the new position, the collimator ([4] in FIG. 2) is again rotated through its mechanical rotation while the signal receiver [10] captures images of the signal emitting module [12]. 5. This process continues until the collimator rotations has been acquired at multiple fixed gantry angles. A minimum of 2 fixed gantry angles are recommended. 6. For each gantry position, the axis of rotation for all the signal emitter positions is computed. 7. The isocenter is then determined as the point in space that minimizes the maximum distance from the isocenter to all computed axes.

(47) Determining the Radiation Isocenter (with Couch Considered) 1. The process described above for determining radiation isocenter without couch is followed except for the added step that the couch axis of rotation is measured. 2. The couch axis of rotation is combined with all the collimator axes of rotation. Isocenter is then determined as the point in space that minimizes the maximum distance from the isocenter to all computed axes.

(48) Determining the Mechanical Isocenter 1. The mechanical isocenter is set to the intersection point of the axis determined for the gantry, and the collimator. The axis of rotation for the couch may also be determined and included. Since these three axes are rarely truly intersecting, the mechanical isocenter is set to a position that would minimize the maximum distance to any of the computed axes. Other techniques could also be used, such as differential weighting of each axis' contribution to isocenter.

(49) Determining the Gantry Axis of Rotation 1. A signal emitting module [12] is attached to a LINAC collimator [4] via a collimator mount [11] as shown in FIG. 6. A signal receiver [10] is positioned on the LINAC couch [3] in a position to acquire stereoscopic images of the signal emitting module [12] as the gantry rotates. While a maximum rotation amount is preferable for optimal results, partial rotations can also be use in cases where full rotations are not possible. 2. The gantry ([1] in FIG. 1) is rotated through its mechanical rotation while the signal receiver [10] captures images of the signal emitting module [12] at regular time intervals. An example of five acquisitions over a 360° rotation is shown in FIG. 22. 3. For each acquisition, left-right images pairs are sent from signal receiver [10] to a computer to determine the location and orientation of the signal emitting module in three-dimensions. To accomplish this, image process techniques locate the center of each individual emitter (see [51] in FIG. 21) in each image. Stereoscopic image process techniques then compute the three-dimensions coordinates of each individual signal emitter from its location in the left and right-sided images. 4. The location of signal emitting module from all data acquisitions (see FIG. 24) are then fit to a three-dimension circular path, the central axis of which represents the gantry axis of rotation ([2] in FIG. 1).

(50) Determining the Collimator Axis of Rotation 1. The system is configured as described for Determining the Gantry Axis of Rotation. 2. The identical steps described for Determining the Gantry Axis of Rotation are followed except that instead of rotating the gantry, the collimator ([4] in FIG. 2) is rotated. While a maximum rotation amount is preferable for optimal results, partial rotations can also be use in cases where full rotations are not possible. 3. The identical image processing and data analysis steps described in for Determining the Gantry Axis of Rotation are followed to determine the collimator axis of rotation ([5] in FIG. 2).

(51) Determining the Couch Axis of Rotation 1. The system is configured as described for Determining the Gantry Axis of Rotation. 2. The identical steps described for Determining the Gantry Axis of Rotation are followed except that instead of rotating the gantry, the couch is rotated ([3] in FIG. 3). While a maximum rotation amount is preferable for optimal results, partial rotations can also be use in cases where full rotations are not possible. 3. The identical image processing and data analysis steps described in for Determining the Gantry Axis of Rotation are followed to determine the couch axis of rotation ([6] in FIG. 3).

(52) Positioning a Target Marker on an Axis of Rotation 1. Once a axis of rotation is determined (either gantry, collimator or couch), a target marker can be positioned to any point along this axis (this is useful for the collimator axis when adjusting the direction the radiation beam, commonly referred as “steering”). 2. Without disturbing the camera pod [10] from the setup used to determine isocenter (this will ensure the identical coordinate system), the isocenter target module [21] is positioned on the positioning module as shown in FIG. 11. 3. The isocenter target module consists of a set of signal emitters ([25] in FIG. 11) positioned precisely relative to a radiation opaque spherical marker [36] embedded within a target body [26]. 4. The signal receiver [10] is set to capture images of the isocenter target module's signal emitters [25]. These images are sent to a computer to determine the location of the isocenter target module in three-dimensions through imaging processing techniques identical to those used for gantry axis determination. Summarized again here, these images are analyzed to find the center of each individual emitter (see [51] in FIG. 21) in three-dimensions coordinates. The isocenter target module's position and orientation in space are then determined registering those found locations against the expected locations individual emitter locations. This registration process is used to determine the orientation and location of the signal emitter for each acquisition. 5. For each image pair acquisition, the found location of the isocenter target module's radiation opaque spherical marker is compared to the axis of interest and the software instructs the user how to shift the isocenter target module in three dimensions to align the marker to the axis. FIG. 13 shows the X dial [28], the Y dial [29], and the Z dial [27] that can be used to accomplish these shifts. The software provides real-time feedback to guide the user during this process.

(53) Positioning a Target Marker at Isocenter 1. Once the mechanical or radiation isocenter is determined, a target marker can be positioned to that isocenter (this is useful since tests must performed that confirm that radiation is properly focused towards radiation isocenter). 2. Without disturbing the camera pod [10] from the setup used to determine isocenter (this will ensure the identical coordinate system), the isocenter target module [21] is positioned on the positioning module as shown in FIG. 11. 3. The isocenter target module consists of a set of signal emitters ([25] in FIG. 11) positioned precisely relative to a radiation opaque spherical marker [36] embedded within a target body [26]. 4. The signal receiver [10] is set to capture images of the isocenter target module's signal emitters [25]. These images are sent to a computer to determine the location of the isocenter target module in three-dimensions through imaging processing techniques identical to those used for gantry axis determination. Summarized again here, these images are analyzed to find the center of each individual emitter (see [51] in FIG. 21) in three-dimensions coordinates. The isocenter target module's position and orientation in space are then determined registering those found locations against the expected locations individual emitter locations. This registration process is used to determine the orientation and location of the signal emitter for each acquisition. 5. For each image pair acquisition, the found location of the isocenter target module's radiation opaque spherical marker is compared to found isocenter and the software instructs the user how to shift the isocenter target module in three dimensions to align the two positions. FIG. 13 shows the X dial [28], the Y dial [29], and the Z dial [27] that can be used to accomplish these shifts. The software provides real-time feedback to guide the user during this process.

(54) Determining the Collimator Axis Walkout 1. A signal emitting module [12] is attached to a LINAC collimator [4] via a collimator mount [11] as shown in FIG. 6. A signal receiver [10] is positioned on the LINAC couch [3] in a position to acquire stereoscopic images of the signal emitting module [12] as the collimator rotates. While a maximum rotation amount is preferable for optimal results, partial rotations can also be use in cases where full rotations are not possible. 2. The collimator ([1] in FIG. 1) is rotated through its mechanical rotation while the signal receiver [10] captures images of the signal emitting module [12] at regular time intervals. 3. For each acquisition, left-right images pairs are sent from signal receiver [10] to a computer to determine the location and orientation of the signal emitting module in three-dimensions. To accomplish this, image process techniques locate the center of each individual emitter (see [51] in FIG. 21) in each image. Stereoscopic image process techniques then compute the three-dimensions coordinates of each individual signal emitter from its location in the left and right-sided images. 4. The location of signal emitting module from all data acquisitions are then fit to a three-dimension circular path. This fit circular path represents the ideal path the emitter would have taken if the collimator rotation were “ideal”, i.e. it had no errors or deviations in its mechanical rotation. 5. For each measured signal emitting module position, the vector between that position and the nearest point on the fit circular path represents the error for that position. The set of all error vectors represent the walkout for that axis.

(55) Determining the Couch Axis Walkout 1. The system is configured as described for Determining the Collimator Axis Walkout. 2. The identical steps described for Determining the Collimator Axis Walkout are followed except that instead of rotating the collimator, the couch is rotated ([3] in FIG. 3). While a maximum rotation amount is preferable for optimal results, partial rotations can also be use in cases where full rotations are not possible. 3. The identical image processing and data analysis steps described in for Determining the Collimator Axis Walkout are followed to determine the couch axis walkout.

(56) Adjustment of the Room Lasers 1. The target body [26] of the isocenter target module contains a radiation opaque spherical marker [36] which is embedded in a position orthogonally aligned with the four sets of cross-hairs [35] scribed on the outer surfaces (see cross-sectional view in FIG. 16). 2. The crosshairs on the outside of the target body allow room laser to be adjusted so that they precisely align with the radiation opaque sphere located inside (which is not visible). 3. Once the radiation opaque sphere [36] is aligned with the found isocenter (described in the steps above), the left, right, and top room lasers are manual adjusted so that they are focused on the crosshairs present on left, right, and top of the target body ([26] in FIG. 11)

(57) Determining the Direction of Gravity 1. Instead of using a typical spirit level to align the gantry level with the earth's gravitational field, a gravity module [37] shown in FIG. 17 can be connected to the LINAC via the collimator mount [11]. 2. The gravity module shown in cross-section in FIG. 20 contains a pendulum ball [45] suspended by a flexible wire [44]. The pendulum ball is surrounded a viscous fluid (typically water) contained within a vessel [46]. The fluid rapidly dampens oscillations of the ball (without the dampening fluid, the time required for the pendulum to stop oscillating would be prohibitive). 3. The signal receiver module acquires image pairs of the gravity module and uses signal processing techniques to determine the direction in space of the pendulum wire, which correlates to the direction of the gravity vector. 4. FIG. 28 shows a graphical description of the mathematical process used: the pendulum wire [44] is detected within the left image [53] and right image [56] acquired by the camera pod. 5. The pendulum wire line is mathematically projected out from the camera focal point to create left-sided plane [55] and a right-sided plane [58] 6. The intersection of the two planes is computed and represents the direction of the gravity vector [59].

(58) Software Overview 1. Initialize a coordinate system that correlates to real-world coordinates of the signal emitting module, 2. Display the signal emitting module location in real-time (both in 3D view and 2D projections). 3. Show the signal emitting module position and orientation when recording a rotation. 4. Compute the direction of gravity within the previously initialized coordinate system. 5. Compute the rotational axes (gantry, collimator or couch). 6. Show the positions of the computed axes in a 3D view and in 2D projections. 7. Compute the LINAC mechanical or radiation isocenter based on the computed axes of rotation 8. Show the LINAC isocenter in 3D and 2D views. 9. Create reports for presenting the LINAC rotational axes and LINAC isocenter. 10. Store previous datasets to allow for post-processing and data review. 11. Uses the walkout radii of each of the three axes to compute an overall LINAC walkout radius.

(59) The LINAC mechanical isocenter determination process includes mounting a signal emitter module on a collimator; mounting a signal receiver module at a location with an unobstructed view of the signal emitter module; determining the an axis of rotation for the gantry by rotating the gantry with the signal receiver module receiving signals from the signal emitter module during the gantry rotation; determining an axis of rotation for a collimator by rotating the collimator with the signal receiver module receiving signals from the signal emitter module during the collimator rotation; and determining the LINAC mechanical isocenter by processing the signals received for the axis of rotation for the gantry the axis, and the collimator.

(60) The axis of rotation for the couch can be determined by mounting the signal receiver module on the couch and rotating the couch with the signal receiver module receiving signals from the signal emitter module during the couch rotation. The LINAC mechanical isocenter can then be determined by processing the signals received for the axis of rotation for gantry, the collator, and the couch.

(61) In one embodiment for the LINAC mechanical and radiation isocenter determination processes the signal emitter module emits light signals and the signal receiver module receives the light signals. But as stated other signal sources can be utilized such as infrared imaging, or by triangulation of ranging systems including RF ranging, laser ranging, lidar, or sonar, or other similar techniques such as utilizing laser beams.

(62) The signal emitter module comprises a minimum of one marker reflecting or omitting light at a specific frequency optimized for the signal receiver.

(63) The LINAC Isocenter determination process can include mounting an isocenter target module on the positioning module and positioning an isocenter target marker located in the isocenter target module at the LINAC isocenter. The isocenter target module includes a minimum of one target marker. The isocenter target module may include a radiation opaque marker inside a target body and also may include crosshairs on an outside of the target body. This allows lasers to be adjusted by focusing on the LINAC isocenter.

(64) In one embodiment the positioning module includes mechanism(s) to adjust the X, Y, and Z positions. Individual controls for X, Y, and Z positions can be provided or a joystick type mechanism can be used for all three.

(65) The LINAC mechanical isocenter determination process may include utilizing a processor to collect data and process it utilizing software.

(66) In one embodiment a gravity module is mounted on the collimator and the camera pod acquires images of location of the gravity module to be used in determine the direction of a gravity vector.

(67) In another embodiment the signal receiver module is fixed on collimator and signal emitter module mounted on the couch. The signal receiver module can be mounted in any location with an unobstructed view of the signal emitter.

(68) In another embodiment the LINAC radiation isocenter determination process includes: mounting a signal emitter module on a collimator; mounting a signal receiver module in a location with an unobstructed view of the signal emitter module; rotating a collimator with a gantry positioned at a first angle while the signal receiver captures the position and orientation of the signal emitter module; rotating the collimator with the gantry positioned at a second angle while the signal receiver captures the position and orientation of the signal emitter module; determine a calculated three-dimensional collimator axis of rotation with the gantry positioned at the first and with the gantry positioned at the second angle; and determining the LINAC radiation isocenter using the calculated using the calculated collimator axis of rotation with the gantry positioned at the first angle and the calculated collimator axis of rotation with the gantry positioned at the second angle.

(69) In another embodiment the collimator is rotated with the gantry at a minimum of 1 additional angle.

(70) The LINAC radiation isocenter determination process may include rotating the couch to include in the calculation of the radiation isocenter.

(71) Disclosed is a LINAC gantry axis of rotation determination process including mounting a signal emitter module on a collimator; mounting a signal receiver module at a location with an unobstructed view of the signal emitter module; and determining the gantry axis rotation by rotating the gantry with the signal receiver module receiving signals from the signal emitter module during the gantry rotation.

(72) Disclosed is a LINAC collimator axis of rotation determination process comprising:

(73) mounting a signal emitter module on a collimator; mounting a signal receiver module at a location with an unobstructed view of the signal emitter module; and determining the collimator axis rotation by rotating the collimator with the signal receiver module receiving signals from the signal emitter module during the gantry rotation.

(74) Disclosed is a LINAC couch axis of rotation determination process comprising: mounting a signal emitter module on a collimator; mounting a signal receiver module at a location with an unobstructed view of the signal emitter module; and determining the collimator axis rotation by rotating the couch with the signal receiver module receiving signals from the signal emitter module during the gantry rotation.

(75) Disclosed is a process to determine the collimator axis walkout determination process comprising: mounting a signal emitter module on a collimator; mounting a signal receiver module at a location with an unobstructed view of the signal emitter module; determining the path through space of the signal emitter during collimator rotation by analyzing the signals receiver data acquired during the rotation; fitting the computed signal emitter positions to a three-dimensions circle in space; and computing an error vector between each position and the nearest point to the fit three-dimensional circle.

(76) Also disclosed is a process to determine the couch axis walkout including: mounting a signal emitter module on a collimator; mounting a signal receiver module at a location with an unobstructed view of the signal emitter module; determining the path through space of the signal emitter during couch rotation by analyzing the signals receiver data acquired during the rotation; fitting the computed signal emitter positions to a three-dimensions circle in space; and computing an error vector between each position and the nearest point to the fit three-dimensional circle.

(77) Having described preferred embodiments which serve to illustrate various concepts, structures and techniques which are the subject of this patent, it will now become apparent to those of ordinary skill in the art that other embodiments incorporating these concepts, structures and techniques may be used. Accordingly, it is submitted that that scope of the patent should not be limited to the described embodiments but rather should be limited only by the spirit and scope of the following claims.