Flexible electronic structure and method for producing same
11812559 · 2023-11-07
Assignee
Inventors
Cpc classification
H05K2203/1184
ELECTRICITY
H05K3/32
ELECTRICITY
H01L2221/6834
ELECTRICITY
H05K3/007
ELECTRICITY
H05K1/118
ELECTRICITY
H05K2203/308
ELECTRICITY
H05K1/0271
ELECTRICITY
H01L2224/81203
ELECTRICITY
H01L2224/8185
ELECTRICITY
H01L2221/68381
ELECTRICITY
H05K2201/2009
ELECTRICITY
H01L2224/97
ELECTRICITY
H05K2201/10803
ELECTRICITY
H05K3/0052
ELECTRICITY
H01L24/97
ELECTRICITY
H05K1/189
ELECTRICITY
H01L21/568
ELECTRICITY
H05K2203/0384
ELECTRICITY
H01L23/5384
ELECTRICITY
H01L2224/16225
ELECTRICITY
H01L2224/81001
ELECTRICITY
H01L2221/68345
ELECTRICITY
H01L2224/97
ELECTRICITY
H05K1/186
ELECTRICITY
A61B2562/164
HUMAN NECESSITIES
H05K1/183
ELECTRICITY
H01L2224/16227
ELECTRICITY
H05K2203/016
ELECTRICITY
International classification
H05K1/18
ELECTRICITY
H05K1/11
ELECTRICITY
Abstract
A flexible electronic structure includes a first film, made of a first polymer or glass, and a second film, made of a second polymer, in which at least one electronic component is arranged. The second film covers the first film. The flexible electronic structure also includes at least one electrically conductive track arranged between the first film and the second film, and each electrically connected to one of the electronic components, by a respective interconnection element. Optionally, the flexible electronic structure includes a third film, made of a third polymer or glass, covering the second film. The interconnection element is arranged near the neutral plane of the structure, and the structure includes at least one compensation layer, so as to position the neutral plane at a desired location.
Claims
1. A flexible electronic structure comprising: a first film, made of a first polymer or of glass, a second film, made of a second polymer, wherein at least one electronic component is disposed, the second film covering the first film, at least one electrically conductive track, disposed between the first film and the second film, and each electrically connected to one of the at least one electronic component, by a respective interconnection element, and each interconnection element being disposed near a neutral plane of the structure, at a position through which a plane passes whose distance from the neutral plane is less than or equal to 20% of a total thickness of the structure, wherein the structure further comprises at least one discontinuous compensation layer, formed of one or more discrete portions which each extend opposite one of the at least one electrically conductive track, respectively opposite one of the at least one electronic component, wherein the neutral plane is located in the structure at a surface where compressive and tensile stresses compensate each other when the structure is subject to a bending process, and wherein a respective metal via, electrically connected to one of the at least one electrically conductive track, extends in the first film so as to connect one of the at least one electronic component through the first film, the metal via being filled with the second polymer.
2. The structure according to claim 1, further comprising a third film made of a third polymer or of glass, covering the second film.
3. The structure according to claim 2, wherein the third film and the compensation layer are made of glass, and formed together integrally.
4. The structure according to claim 2, wherein the compensation layer is disposed between the second film and the third film, consisting of portion(s) each located opposite one of the at least one electrically conductive track.
5. The structure according to claim 2, wherein the compensation layer covers the third film, and consists of portion(s) each located opposite one of the at least one electrically conductive track.
6. The structure according to claim 2, comprising at least one sealing trench, each surrounding one of the at least one electronic component, the polymer of the third film filling the sealing trench.
7. The structure according to claim 2, wherein the first polymer and the third polymer are identical.
8. The structure according to claim 2, wherein at least one through-hole extends in the first film and/or in the third film each so as to make one of the at least one electronic component accessible.
9. The structure according to claim 1, wherein the second film comprises several electronic components of different surface areas, and wherein the compensation layer covers the electronic component of smallest surface area so as to stiffen it.
10. The structure according to claim 1, wherein the compensation layer consists of portion(s) each located opposite one of the at least one electrically conductive track, the first film being disposed between the electrically conductive track and the compensation layer.
11. The structure according to claim 1, comprising two compensation layers which are separate from each other.
12. The structure according to claim 1, wherein at least one compensation layer is made of the same material as at least one electrically conductive track.
13. The structure according to claim 1, further comprising at least one metal tip, electrically connected to one of the at least one electrically conductive track by means of a corresponding via, and protruding from the first film on a side opposite to the electrically conductive track, the tip being filled with the second polymer.
14. A method for producing the flexible electronic structure according to claim 1, said method comprising the following successive steps: a) providing a substrate, b) forming the first film made of a first polymer or of glass, on the substrate, c) forming at least one electrically conductive track on the first film, d) forming the second film made of a second polymer, wherein at least one electronic component is disposed, each electronic component being electrically connected with one of the at least one electrically conductive track by a respective interconnection element, and e) separating the substrate from the flexible electronic structure, the method further comprising at least one step of forming at least one compensation layer.
15. The method according to claim 14, wherein step d) comprises the following sub-steps: forming a solid film made of the material of the second film, etching the solid film, so as to form at least one cavity, each cavity making one of the at least one electrically conductive track accessible, and transferring a respective electronic component into the cavities and connecting each electronic component with the at least one of the at least one electrically conductive track, each connection being made by means of a respective interconnection element.
16. The method according to claim 14, wherein step d) comprises the following sub-steps: transferring and connecting at least one electronic component, each with the at least one of the at least one electrically conductive track, each connection being made by means of a respective interconnection element, and forming the second film on the at least one electronic component and on the first film.
17. The method according to claim 14, wherein, between step a) and step b), a sacrificial layer is deposited on the support and in that during step e), the sacrificial layer is etched to separate the support from the flexible electronic structure.
18. The method according to claim 14, configured to produce a flexible electronic structure further including a third film made of a third polymer or of glass, covering the second film, wherein: before step b), one of the at least one compensation layer is formed on the substrate, and/or after step d), one of the at least one compensation layer is formed on the second film, and/or after step d), one of the at least one compensation layer is formed on the third film.
19. The method according to claim 14, wherein the first polymer is a polyimide, a polysiloxane, a parylene or a thermoplastic polymer.
20. The method according to claim 14, wherein the substrate includes at least one recess in the shape of a tip, forming an indentation to form at least one metal tip protruding from the first film, on a side opposite to the at least one electrically conductive track.
21. The structure according to claim 1, wherein the neutral plane is located between the at least one electrically conductive track and the at least one electronic component.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
(1) The present invention will be better understood on the basis of the description which follows and the appended drawings wherein:
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(16) The different parts in the figures are not necessarily shown with a uniform scale, to make the figures more readable.
(17) The various possibilities (variants and embodiments) must be understood as not being mutually exclusive and can be combined with each other.
DETAILED DESCRIPTION OF PARTICULAR EMBODIMENTS
(18) First, reference is made to
(19) The person skilled in the art will be able to combine the various embodiments with each other in different ways.
(20) Flexible Electronic Structure:
(21) As shown in
(22) The structure 100 comprises in particular a first film 101, a second film 102, an optional third film 103, at least one electronic component 300 electronically connected to at least one respective electrically conductive track 200, and at least one compensation layer 500.
(23) For greater readability, only the first film 101, the second film 102 and the third film 103 as well as an electronic component 300 are shown in
(24) The flexible electronic structure 100 can be directly worn by a person, for example on a wrist, an arm or a torso. The electronic structure 100 can be used for medical or welfare applications for example. By way of illustration, the structure 100 can be an integral part of a device for measuring temperature, heart rate, actimetrics, or degassing of the skin (sweat), or else of an electrical or optical stimulation device, or a drug delivery device. The structure can be wound around a catheter, for example. The flexible electronic structure 100 can be directly transferred to any type of object with more or less round shapes.
(25) The structure 100 has a thickness comprised between 20 μm and 400 μm, preferably between 50 μm and 150 μm and even more preferably of the order of 100 μm.
(26) Throughout the text, the term “thickness” refers to a dimension along an axis perpendicular to the stack of polymer or glass films.
(27) The plane of the flexible electronic structure is also defined as being a plane orthogonal to the axis of the thickness, parallel to which each of the polymer or glass films extend.
(28) The neutral plane of the structure (also called neutral fiber) is represented by the dotted line PN in the different figures. The mechanical stresses during bending are minimal in this plane and the elements disposed in this plane keep their integrity. According to the invention, the neutral plane is at the electrical connections between the electronic components 300 and the electrically conductive tracks 200.
(29) The First Film 101:
(30) The first film 101, also called the lower film, is bendable. Bendable means that the film can undergo bending with a radius of curvature less than or equal to 1000 mm and preferably less than or equal to 200 mm without breaking.
(31) The first film 101 is made of polymer or of glass. The term “polymer” is preferably understood here and below to mean a homopolymer or a copolymer. By way of illustration, the polymer can be selected from the following non-exhaustive list (the Young's modulus has been indicated in brackets): a polyimide (from 2 to 8 GPa, for example 3.2 Pa), a polymerized siloxane (from 0.05 to 0.5 GPa, for example 0.15 GPa) such as silicone (less than 0.1 GPa) or a siloxane polymer SINR™, parylene (2.4 to 3 GPa), a thermoplastic such as polyethylene (200-700 MPa), polyethylene terephthalate or PET (2800-3100 MPa), poly(ethylene naphthalate) or PEN (500-1500 MPa), etc. Its thickness ranges from 5 μm to 150 μm, preferably from 10 μm to 75 μm, and even more preferably from 10 μm to 30 μm. Note that when the first film is made of glass, it has a higher Young's modulus (from 69 to 72 GPa) so that it then has a thickness located in the lower part of the thickness ranges indicated above.
(32) The Second Film 102:
(33) The second film 102 (also called an inner film) is made of a bendable polymer material. It is advantageously made of a material able to fill vias or trenches. This can be a thermoplastic or a siloxane polymer SINR™. Alternatively, it can also be a polyimide, a polymerized siloxane such as silicone or parylene. The thickness of this film ranges from 5 μm to 150 μm, preferably from 10 μm to 75 μm, and even more preferably from 10 μm to 30 μm.
(34) The Third Film 103 (Optional):
(35) The third film 103 (also called the upper film) is made of a bendable material. The material of the third film is a polymer or a glass film. This can be a polyimide, a polymerized siloxane such as silicone or siloxane polymer SINR™, a thermoplastic, parylene or a glass. It will advantageously be made of a material able to fill vias or trenches. The thickness of this film ranges from 5 μm to 150 μm, preferably from 10 μm to 75 μm, and even more preferably from 10 μm to 30 μm.
(36) As shown in
(37) According to variants, the second film 102 may have a thickness smaller or greater (
(38) When the second film 102 has a thickness greater than that of the electronic component 300 and covers it, the structure may not comprise a third film 103. For example, in this embodiment, the second film 102 may have a thickness approximately twice as large as that of the first film 101, so as to maintain the neutral plane at the level of the connection between the electronic component 300 and the electrically conductive track 200, without the need to add a third film above the second film.
(39) The three films (first 101, second 102 and third 103 films) can be made of different or identical materials.
(40) Preferably, the first film 101 and the third film 103 are made of the same material. The mechanical properties of the structure 100 (flexibility in particular) are thus better balanced. The material of the first film 101 and/or of the third film 103 can be biocompatible materials, for example polysiloxane.
(41) In a particular embodiment, shown in
(42) Electrical Tracks 200:
(43) The electrically conductive tracks 200, or electrical tracks 200, are disposed within the structure 100, between the first film 101 and the second film 102, as close as possible to the neutral plane.
(44) The electrical tracks 200 are electrically conductive. They can be metallic, for example Cu, Ag, Au, Al, W, Ni, Pt, Ti or Ru. In the case of a structure which has to be biocompatible, for example for medical applications, a noble metal will be selected, such as for example, gold or platinum. The electrical tracks 200 can also be made from an ink loaded with metal particles like those used in organic electronics. The thickness of the tracks 200 may be from 50 nm to 5 μm, and preferably from 100 nm to 2 μm.
(45) As shown in
(46) As shown in
(47) The thicknesses of the films mentioned above do not take into account any vias or any tips.
(48) In a variant shown in
(49) The Integrated Electronic Component 300:
(50) The component 300 integrated into the structure 100 can be selected from an ASIC (that is to say an integrated circuit with specific application), a sensor, an actuator, a stimulator, a battery, an RFID (that is to say radiofrequency identification) chip, or a passive component. The face of the component in contact with the electrical connection pads 400 is facing the first film 101, in order to be able to electrically connect each connection pad to one of the electrically conductive tracks 200. The component 300 is, for example, made of silicon.
(51) Once integrated into the structure, the electronic component 300 has a thickness comprised between a few tens, even a few hundreds of micrometers, and around ten micrometers. It has for example a thickness comprised between 10 μm and 350 μm. Its thickness is for example comprised between 100 μm and 150 μm. Alternatively, it has a thickness less than 100 μm, and preferably less than 50 μm, for example from 20 μm to 50 μm, to maximize the flexibility properties of the structure.
(52) As shown in
(53) The structure 100 can comprise one or more components 300, of the same surface area or of different surface areas, of the same nature or of different natures. For example, it is possible to have an RFID chip and a sensor.
(54) Preferably, but optionally, and as shown in
(55) The Interconnection Element 400 Between the Electrically Conductive Track 200 and the Integrated Electronic Component 300:
(56) The interconnection element 400, or interconnection pad, electrically and mechanically connects each electrically conductive track 200 with a component 300. The interconnection element 400, the electrical track 200 and the electronic component 300 are integral.
(57) A same electronic component 300 can be connected to one or more electrical tracks 200. For example in
(58) The interconnection element 400 is electrically conductive. For example, it can be made from fusible brazing based on tin or lead, for example, such as SnAg, SnPb or SnAgCu. It can also be a bump, preferably gold, better known as a “stud bump” or “accu bump”. It can also be a conductive adhesive. It can also be a conductive ink, for example silver-based conductive ink. It can also be part of a conductive element, such as a metal pillar, called a micro-insert, micro-tube (or pilar), according to the techniques used to connect the electronic component 300 to the electrical track 200.
(59) The interconnection element 400 has a thickness ranging from 0.5 μm to 70 μm. Preferably, the interconnection element has a thickness greater than 10 μm only if it is a “stud bump”.
(60) According to the invention, the interconnection element 400 passes through a plane whose distance from the neutral plane is less than or equal to 20% of a total thickness E of the structure 100. Said distance is measured in one direction or the other, along an axis orthogonal to the plane along which extends the flexible structure.
(61) When the interconnection element 400 is a “stud bump” type bump, it has a high thickness, greater than 10 μm. Such an interconnection element 400 is initially attached to one among the electrical track 200 and the component 300, by fusion, then attached to the other among the electrical track 200 and the component 300, by simple thermo-compression. The attachment made by thermo-compression is the most fragile of the two attachments. Consequently, the face of the interconnection element which is attached by thermo-compression is positioned closest to the neutral plane. The thermo-compression attachment can be at the interface between the interconnection element 400 and the electrical track 200, or at the interface between the interconnection element 400 and the electronic component 300.
(62) By way of illustration only, in the case of a stack comprising an upper layer and a lower layer, stacked on top of each other, and homogeneous, the position of the neutral plane can be calculated with the formula described in the respective articles of Suo and al. (“Interface crack between two elastic layers”, International Journal of Fracture 43: 1-18, 1990) and Eberl and al. (“Mechanical Characterization of Coatings Using Microbeam Bending and Digital Image Correlation Techniques”, Experimental Mechanics DOI 10.1007/s11340-008-9187-4):
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(64) For example, in the case of a stack having: an upper silicon layer with the following features: h.sub.up=45 μm, E.sub.up=130 GPa, a lower polymer layer with the following features: h.sub.low=100 μm, E.sub.low=2.5 GPa,
(65) the position of the neutral plane h.sub.0 is at 120 μm, that is to say the neutral plane is in the upper layer.
(66) The displacement of the neutral plane can be achieved, for example, by adding a metal layer of nickel (10 μm thick and 214 GPa of Young's modulus) or of ruthenium (5 μm thick and 447 GPa of Young's modulus), under the stack, that is to say in contact with the lower layer. The new position of the neutral plane is, respectively, at 110 μm and at 105 μm.
(67) The Compensation Layer 500:
(68) As shown in the figures, the structure further comprises a compensation layer 500, also called a compensating layer, to locally stiffen the structure in its most flexible region, and thus change the position of the neutral plane of the structure.
(69) The compensation layer 500 is a layer consisting of discrete portions spaced apart from each other.
(70) The compensation layer 500 allows to stiffen, for example, the upper part of the structure just like the at least one electrical track 200 stiffens the lower part of the structure (
(71) The person skilled in the art will select the materials and thicknesses of the at least one electrical track 200 and the compensation layer 500 so as to locate the at least one interconnection element 400 as close as possible to the neutral plane. The compensation layer 500 and the at least one electrical track 200 can be of the same material and/or have the same thickness.
(72) For example, the compensation layer 500 is metal. It can be made of Cu, Ag, Au, Al, W, Ni, Pt or Ti. For applications requiring biocompatibility, a noble metal will be selected, such as, for example, gold or platinum.
(73) It can also be a loaded ink, such as those used in organic electronics, or a polymer.
(74) The thickness of the compensation layer may be comprised between 100 nm and 10 μm, for example comprised between 0.5 μm and 10 μm or between 100 nm and 5 μm, and preferably between 0.5 μm and 2 μm.
(75) According to a first embodiment, the compensation layer 500 consists of portion(s) each disposed above one of the electrically conductive tracks 200, each opposite one of the electrical tracks 200. The compensation layer 500 then extends on the side of the second film 102 opposite to the first film 101.
(76) According to a first variant shown in
(77) According to another variant, as shown in
(78) In the variant illustrated in
(79) In the variant illustrated in
(80) In both variants, the third film is delimited by a flat surface, on the side opposite to the second film.
(81) According to another variant, not shown, the structure 100 does not include the third film 103, and the compensation layer 500 extends directly over the second film 102, formed of portion(s) each located opposite one of the electrical tracks 200. Preferably, each portion of the compensation layer 500 does not cover the at least one component 300.
(82) According to a second embodiment as shown in
(83) In each of these embodiments, the compensation layer 500, when projecting relative to the stack of films 101, 102, 103, is not taken into account in determining the total thickness of the structure 100.
(84) According to a variant not shown, the structure 100 can comprise at least one additional compensation layer which can be made of the same material as the at least one electrically conductive track 200.
(85) When the structure 100 comprises at least two components 300 of different surface areas, the position of the neutral plane is changed, relative to the position it would have with two components 300 of the same size. The term surface area is understood to mean the dimension orthogonal to the stacking axis of the films 101, 102 and 103. To compensate for this effect, the component 300 of smallest surface area can be stiffened by adding a compensation layer 500 consisting of a portion covering only this component 300 of smallest surface area (
(86)
(87) Production Method:
(88) The method for producing such a structure 100 will now be described. The method includes the following successive steps: a) providing a substrate 700 (
(89) The substrate 700 is a stiff and temporary support. It is used as the basis for producing the structure 100 and will be removed when the structure is completed. It is not part of the final flexible structure 100. The support 700 is advantageously flat. The support 700 is, for example, made of silicon or of glass. The support does not need to be monocrystalline and can therefore be made of polycrystalline silicon, the cost of which is much lower.
(90) According to a variant illustrated in
(91) The substrate 700 preferably comprises a sacrificial layer 701 (also called a stopper layer) which can be etched to free the structure 100 from the substrate 700, or be used as a stopper layer, in the case of mechanical thinning of the substrate 700 (step F). The sacrificial layer 701 can be made of a material that is easy to be chemically etched. When the films 101 and 103 are made of polymer, it is preferably a metal such as titanium which is etched very quickly with hydrofluoric acid.
(92) The sacrificial layer 701 can also be a resin or an adhesive film, or a photosensitive polymer, or a stack of layers whose adhesion can be broken mechanically or thermally.
(93) The sacrificial layer 701 can be deposited by spin-coating, by physical vapor deposition or by rolling.
(94) According to a variant not shown, before step b), a compensation layer 500 can be formed on the substrate 700, or on the sacrificial layer if the substrate 700 comprises one, so as to be directly in contact with the first film 101. The compensation layer 500 may consist of discrete portions each extending opposite one of the electronic components, under the associated electrically conductive track, and/or opposite the one electrically conductive track. The compensation layer 500 can be deposited and etched by microelectronic methods known to the person skilled in the art.
(95) In step b), the first film 101 is formed. The first film 101 can be deposited in the liquid state by spin-coating on the substrate 700 then thermally hardened, for example by evaporation. It can also be deposited by rolling a dry film. One or more vias 201 can be made in the first film 101 (
(96) The electrically conductive track 200 and the interconnection element 400 are then produced (step c). The latter allows to interconnect the components by brazing, bonding, or mechanical compression during step d). When the first film 101 includes vias 201, respectively vias and protruding tips, they will be metallized during this step. The electrical tracks 200 are deposited and etched by microelectronic methods known to the person skilled in the art.
(97) In step d), the second film 102, wherein the electronic component 300 is encapsulated, is formed. The second film 102 is, preferably, deposited in the liquid state. During the deposition, it fills the vias 201 of the underlying layer 101 (
(98) In a first variant, step d) can be carried out by: forming a solid film 102′ made of the material of the second film 102 (
(99) The cavities in the second film 102 can be etched by microelectronic methods known to the person skilled in the art: plasma etching, laser etching, ion etching, chemical etching.
(100) After step d), and prior to the etching step, a compensation layer 500 can be formed on the second film 102 (
(101) According to another variant, step d) can be carried out by: transferring and connecting each electronic component 300 each on one of the electrically conductive tracks 200, forming the second film 102 on the at least one electronic component 300 and on the first film 101.
(102) In this variation, when the second film 102 is thick enough to completely encapsulate the components 300, both sideways and on top, there will be no need to deposit a third film 103.
(103) The electronic components 300 are transferred, the active face down (in “flip chip”), that is to say the face including the interconnection pads facing the film 101. The transfer will be carried out by microelectronic methods known to the person skilled in the art. The second film 102 surrounds the components 300 while being able to leave a trench 112 around them. The trench 112 is then a trench called sealing trench. It will be filled with the material of the upper layer during its formation (step e).
(104) The electrical and mechanical interconnection of the components on the electrical tracks can be made using fusible balls (for example made of SnAg, SnPb or SnAgCu etc.) or else using a conductive adhesive. It can also be made by a gold bump better known under the name of “stud bump” or “accu bump”. The interconnection element 400 is formed in this step.
(105) It may be considered to achieve a specific finish (for example in a Ti\Ni\Au multi-layer known as UBM (“Under Bump Metallization”)) on the electrical tracks and/or under the pads of the electronic components, to boost bonding.
(106) A non-conductive adhesive can be added under the components 300 so as to reinforce the mechanical cohesion.
(107) Alternatively, the components 300 could be connected to their electrical track 200 by a mechanical assembly without fusion of the micro-insert or micro-tube type known to the person skilled in the art. This involves, for example, growing metal micro-pillars or micro-tubes, having a diameter and/or a height of a few μm to a few tens of μm, on the electrical pads of the components 300. When transferring the component 300, a sufficient pressure is exerted so that these protuberances are mechanically inserted into the host metal layer.
(108) A thermo-compression step can be carried out to promote electrical interconnection.
(109) In a particular embodiment, the components 300 can be thinned (
(110) The third film 103 is then deposited on the second film 102 and on the components 300 so as to cover them (step e,
(111) The various films 101, 102, 103, when they are made of polymer, are advantageously formed at a temperature compatible with a rapid and controlled evaporation of the solvent containing the polymer.
(112) According to a variant of the method not shown, after step e), a compensation layer 500 can be formed on the third film 103.
(113) Alternatively, a thick layer of glass (about 100 μm thick) is deposited on the second film 102, which is locally etched over only a part of its thickness. Thus, a glass layer including extra thicknesses which form the discrete portions of the compensation layer 500, is produced. In other words, the glass layer after etching forms a third glass film 103 and a compensation layer 500 which are superimposed.
(114) The structure 100 is then separated from the substrate 700 (step f,
(115) The removal of the substrate 700 will advantageously be achieved by virtue of the sacrificial layer 701. The sacrificial layer 701 can be etched to separate the substrate 700 from the flexible electronic structure 100. It can be etched chemically, for example with hydrofluoric acid. It can be attacked laterally. As shown in
(116) According to one variant, the sacrificial layer 701 can be removed mechanically, for example, by grinding and/or polishing. The sacrificial layer 701 can advantageously be used as a stopper layer.
(117) According to another embodiment, shown in
(118) Advantageously, the second film 102 is etched at the cutting zone 130, so as to locally form a cavity which is filled by the third film 103 during its formation. This can be of interest when it is desired to completely encapsulate the electronic components 300 in a material having specific properties, such as, for example, a biocompatibility.