ALCOHOL-BASED DISINFECTANT FOAM

Abstract

The present invention relates to a disinfectant foam based on alcohol for disinfecting the skin. The disinfection foam according to the invention avoids the disturbance of the skin barrier that is usual with alcohol-based disinfectants and does not require silicone surfactants or polyfluorinated chemicals.

Claims

1. A foamable alcohol-based composition for disinfecting the skin, free from silicone surfactants and free from polyfluorinated chemicals, containing a) ethanol, n-propanol, and/or i-propanol in an aqueous solution with an alcohol content of more than 50%, and b) one or more hydrogenated phospholipids in a proportion of 0.5-5% by weight with respect to the total amount of the liquid.

2. The foamable alcohol-based composition for disinfecting the skin according to claim 1, wherein the hydrogenated phospholipid is selected from phospholipon 80H and/or phospholipon 90H.

3. The foamable alcohol-based composition for disinfecting the skin according to claim 1, wherein the aqueous solution of ethanol, n-propanol, and/or i-propanol has an alcohol content of 60-75% by weight.

4. The foamable alcohol-based composition for disinfecting the skin according to claim 1, wherein the alcohol is ethanol.

5. The foamable alcohol-based composition for disinfecting the skin according to claim 1, containing up to 10% by weight glycerol.

6. The foamable alcohol-based composition for disinfecting the skin according to claim 1, containing up to 1% by weight cellulose ether.

7. The foamable alcohol-based composition for disinfecting the skin according to claim 1, optionally containing 1 to 10% by weight urea.

8. The foamable alcohol-based composition for disinfecting the skin according to claim 1 in a pressure vessel with a spray head for foams, charged with 2-10% by weight of a gas or gas mixture with an equilibrium pressure of 1-5 bar.

9. An alcohol-based disinfectant foam for disinfecting the skin, obtainable by extracting a foamable alcohol-based composition according to claim 1, charged with 2-10% by weight of a gas or gas mixture having an equilibrium pressure of 1-5 bar, from a pressure vessel having a spray head for foams.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0021] The preparation described can be further stabilized by a proportion of ethanol-soluble cellulose ethers, such as Tylose PSO, typically less than 1% by weight.

[0022] Furthermore, the preparation may contain up to 10% by weight glycerol and up to 6% by weight hydrogen peroxide.

[0023] An addition of 1-10% by weight (preferably 2.5-7.5% by weight) urea has proved to be particularly advantageous: Foams according to the invention retain their foam structure and advantageous disinfection properties even with the addition of urea. At the same time, urea-containing foams reduce occasional skin sensitivities to alcohols.

[0024] A number of compositions according to the invention are shown by way of example in Tables 1 to 12. The compositions shown in Tables 1 to 12 are first mixed (typically by stirring the hydrogenated phospholipids into the aqueous alcohol solution at 40 to 60° C.) and then filled into suitable pressure vessels made of glass, aluminum, tinplate, or plastic, closed with a foam valve, e.g., a precision valve, and then preferably pressurized with about 2 to 10% by weight of a gas or a gas mixture (e.g., propane/butane). An equilibrium pressure of 1-5 bar is achieved at room temperature by the gas or gas mixture. By actuating the spray head, the desired quantities of foam can be extracted by a commercially available foam head, e.g., model “Fiji” from Precision Dispensing Solutions Europe.

[0025] The products according to the invention are suitable for effectively disinfecting the skin, in particular the hand. For this purpose, an approximately walnut-sized amount of foam is taken from a dispenser and evenly distributed on the desired part of the body, in particular the hand. The foam is characterized by excellent adhesion to the skin. The adhesion also prevents the dripping of alcohol. A protective screen is formed on the skin, which is hardly soluble in water and acts as a protective barrier. Disinfection can be performed regularly without drying out or otherwise irritating the skin. The foam according to the invention is bactericidal, virucidal, levurocidal, and myobactericidal.

[0026] The compositions according to the invention may contain the emulsifiers and emulsion stabilizers known from similar foams, care agents, viscosity regulators, surfactants, and pH buffers. The addition of film-forming polymers is also possible. In particular, polyvinyl alcohol, PVP, copovidones, cellulose ethers, polyvinyl-co-polymers, and polymethacrylate-co-polymers should be mentioned here. The sum of these optional additives should not exceed 5%.

[0027] The addition of fragrances is possible, but is not recommended to avoid allergy risks.

[0028] By way of example, some compositions are disclosed in the following tables, without these being intended to constitute a limitation. The person skilled in the art can make numerous variations and further developments without having to be inventive.

[0029] Unless otherwise stated, all% figures in this publication are% by weight.

EXAMPLES

[0030] TABLE-US-00001 Constituent A B C D E F Phospholipon 80H 0.5-5% 0.5-5% Phospholipon 90H 0.5-5% 0.5-5% Other hydrated phospholipids 0.5-5% 0.5-5% Ethanol 70% Ad 100% Ad 100% Ad 100% Ethanol 60% Ad 100% Ad 100% Ad 100% Charged with 2 - 10% propane-butane mixture with an equilibrium pressure of 1 - 5 bar (i.e.: 2 to 10 g of propane-butane mixture are added to 100 g of the solutions with the above-mentioned compositions).

TABLE-US-00002 Constituent A B C D E F Phospholipon 80H 0.5-5% 0.5-5% Phospholipon 90H 0.5-5% 0.5-5% Other hydrated phospholipids 0.5-5% 0.5-5% Glycerol 5% 5% 5% 5% 5% 5% Ethanol 70% Ad 100% Ad 100% Ad 100% Ethanol 60% Ad 100% Ad 100% Ad 100% Charged with 2 - 10% propane-butane mixture with an equilibrium pressure of 1 - 5 bar.

TABLE-US-00003 Constituent A B C D E F Phospholipon 80H 0.5-5% 0.5-5% Phospholipon 90H 0.5-5% 0.5-5% Other hydrated phospholipids 0.5-5% 0.5-5% Tylose PSO 0.5% 0.5% 0.5% 0.5% 0.5% 0.5% Ethanol 70% Ad 100% Ad 100% Ad 100% Ethanol 60% Ad 100% Ad 100% Ad 100% Charged with 2 - 10% propane-butane mixture with an equilibriumpressure of 1 - 5 bar.

TABLE-US-00004 Constituent A B C D E F Phospholipon 80H 0.5-5% 0.5-5% Phospholipon 90H 0.5-5% 0.5-5% Other hydrated phospholipids 0.5-5% 0.5-5% Glycerol 5% 5% 5% 5% 5% 5% Tylose PSO 0.5% 0.5% 0.5% 0.5% 0.5% 0.5% Ethanol 70% Ad 100% Ad 100% Ad 100% Ad 100% Ad 100% Ad 100% Charged with 2 - 10% propane-butane mixture with an equilibrium pressure of 1 - 5 bar.

TABLE-US-00005 Constituent A B C D E F Phospholipon 80H 0.5-5% 0.5-5% Phospholipon 90H 0.5-5% 0.5-5% Other hydrated phospholipids 0.5-5% 0.5-5% i-Propanol 70% Ad 100% Ad 100% Ad 100% i-Propanol 60% Ad 100% Ad 100% Ad 100% Charged with 2 - 10% propane-butane mixture with an equilibrium pressure of 1 - 5 bar.

TABLE-US-00006 Constituent A B C D E F Phospholipon 80H 0.5-5% 0.5-5% Phospholipon 90H 0.5-5% 0.5-5% Other hydrated phospholipids 0.5-5% 0.5-5% n-Propanol 70% Ad 100% Ad 100% Ad 100% n-Propanol 60% Ad 100% Ad 100% Ad 100% Charged with 2 - 10% propane-butane mixture with an equilibrium pressure of 1 - 5 bar.

TABLE-US-00007 Constituent A B C D E F Phospholipon 80H 0.5-2, 5% 0.5-2, 5% 0.5-5% 0.5-2, 5% Phospholipon 90H 0.5-2, 5% 0.5-5% 0.5-2, 5% 0.5-5% Other hydrated phospholipids 0.5-2, 5% 0.5-5% 0.5-2, 5% 0.5-5% Ethanol 70% Ad 100% Ad 100% Ad 100% i-Propanol 60% Ad 100% Ad 100% Ad 100% Charged with 2 - 10% propane-butane mixture with an equilibrium pressure of 5 bar.

TABLE-US-00008 Constituent A B C D E F Phospholipon 80H 0.5-5% 0.5-5% Phospholipon 90H 0.5-5% 0.5-5% Other hydrated phospholipids 0.5-5% 0.5-5% Glycerol 6% 8% 10% 6% 8% 10% Ethanol 80% Ad 100% Ad 100% Ad 100% Ethanol 75% Ad 100% Ad 100% Ad 100% Charged with 2 - 10% propane-butane mixture with an equilibrium pressure of 1 - 5 bar.

TABLE-US-00009 Constituent A B C D E F Phospholipon 80H 0.5-5% 0.5-5% Phospholipon 90H 0.5-5% 0.5-5% Other hydrated phospholipids 0.5-5% 0.5-5% Glycerol 10% 8% 6% 10% 8% 6% Tylose PSO 0.5% 0.5% 0.5% 0.5% 0.5% 0.5% Ethanol 75% Ad 100% Ad 100% Ad 100% Ad 100% Ad 100% Ad 100% Charged with 2 - 10% propane-butane mixture with an equilibrium pressure of 1 - 5 bar.

TABLE-US-00010 Constituent A B C D E F Phospholipon 80H 0.5-5% 0.5-5% Phospholipon 90H 0.5-5% 0.5-5% Other hydrated phospholipids 0.5-5% 0.5-5% Glycerol 10% 8% 6% 10% 8% 6% Urea 2.5% 5% 7.5% 7.5% 5% 2.5% Ethanol 75% Ad 100% Ad 100% Ad 100% Ad 100% Ad 100% Ad 100% Charged with 2 - 10% propane-butane mixture with an equilibrium pressure of 1 - 5 bar.

TABLE-US-00011 Constituent A B C D E F Phospholipon 80H 0.5-5% 0.5-5% Phospholipon 90H 0.5-5% 0.5-5% Other hydrated phospholipids 0.5-5% 0.5-5% Urea 2.5% 5% 7.5% 7.5% 5% 2.5% Ethanol 80% Ad 100% Ad 100% Ad 100% Ad 100% Ad 100% Ad 100% Charged with 2 - 10% propane-butane mixture with an equilibrium pressure of 1 - 5 bar.

Comparative Example

[0031] TABLE-US-00012 Constituent A B C D E F Phospholipon 90H 6.0 5.0 6.0 6.0 Phosphatidylcholine 6.0 6.0 Glycerol 1.0 2.0 2.0 Docusate sodium 0.2 0.2 0.2 Menthol 0.2 Geraniol 0.2 Vitamin E acetate 0.6 Ethanol 65.0 65.0 65.0 65.0 65.0 65.0 Water Ad 100% Ad 100% Ad 100% Ad 100% Ad 100% Ad 100%

[0032] The compositions according to Table 13 (A-F) are each mixed under stirring at 40-60° C., poured into a pressure vessel, and charged with approx. 5% propane-butane mixture. The pressure vessel is fitted with a commercially available spray head for foams. The composition of Table 13C corresponds to Example 34 of US 9,023,374 B2.

[0033] At room temperature, an attempt is made to extract an approx. walnut-sized quantity of a foam by actuating the foam head.

[0034] Result: The compositions according to Table 13A and B give excellent, fine-pored foams. The extracted foam remains stable for several minutes. The foam spreads excellently on the skin without dripping.

[0035] The compositions according to Table 13C to D give very coarse-pored foams, which already have a certain liquid content on removal. The foam content dissipates immediately after removal. After considerably less than one minute, there is practically no foam left. When an attempt is made to spread the foam on the hand, liquid drips off the hand.