POWDER COMPOSITION FOR COSMETICS OR SKIN TOPICAL AGENT, AND PRODUCTION METHOD THEREFOR

Abstract

The purpose of the present invention is to provide a powder composition that can be used for cosmetics or skin topical agents and that replaces plastic powder bodies such as a nylon powder body, an acrylic powder body, and a urethane powder body. Provided is a composition which is a powder composition containing (a) acyllysine and (b) cellulose and/or starch, and which has a median diameter of the volume-based distribution of (A) acyllysine of 9 μm or less. The contained amount of (A) is 2-40 mass %, and the contained amount of (B) is 3-95 mass %, with respect to 100 mass % of the total of the powder composition. The total amount of (A) and (B) is 10 mass % or more.

Claims

1. A powder composition comprising: (A) acyllysine; and (B) cellulose and/or starch, a median diameter of a volume-based distribution of the (A) acyllysine being 9 μm or less, wherein a content of the (A) is 2 to 40% by mass, a content of the (B) is 3 to 95% by mass, and a total amount of the (A) and the (B) is 10% by mass or more, in a case where the entire powder composition is considered as 100% by mass.

2. A powder composition comprising: (A) acyllysine; and (B) cellulose and/or starch, wherein a content of the (A) is 2 to 40% by mass, a content of the (B) is 3 to 95% by mass, and a total amount of the (A) and the (B) is 10% by mass or more, in a case where the entire powder composition is considered as 100% by mass, and wherein a water repellent time using an aqueous solution of 35% by mass of ethanol is 30 minutes or more, wherein the water repellent time using the aqueous solution of 35% by mass of ethanol is a time taken for all the powder composition to sediment when 5 g of the aqueous solution of 35% by mass of ethanol is put in a 10-mL glass vial, and 30 mg of the powder composition is disposed on a liquid surface.

3. A powder composition comprising: (A) acyllysine; and (B) cellulose and/or starch, wherein a content of the (A) is 2 to 40% by mass, a content of the (B) is 3 to 95% by mass, and a total amount of the (A) and the (B) is 10% by mass or more, in a case where the entire powder composition is considered as 100% by mass, and wherein a water repellent time using an aqueous solution of 30% by mass of ethanol is 60 minutes or more, wherein the water repellent time using the aqueous solution of 30% by mass of ethanol is a time taken for all the powder composition to sediment when 5 g of the aqueous solution of 30% by mass of ethanol is put in a 10-mL glass vial, and 30 mg of the powder composition is disposed on a liquid surface.

4. The composition according to claim 1, wherein the (B) contains plate-shaped cellulose.

5. The composition according to claim 4, comprising 5 to 65% by mass of the plate-shaped cellulose in the case where the entire powder composition is considered as 100% by mass.

6. The composition according to claim 1, comprising 5 to 90% by mass of starch in the case where the entire powder composition is considered as 100% by mass.

7. The composition according to claim 1, wherein the (B) contains spherical cellulose.

8. The composition according to claim 7, comprising 5 to 95% by mass of the spherical cellulose in the case where the entire powder composition is considered as 100% by mass.

9. The composition according to claim 1, further comprising (C) silica.

10. The composition according to claim 9, wherein the content of the (A) is 2 to 30% by mass, the content of the (B) is 3 to 65% by mass, and a content of the (C) is 30 to 90% by mass, in the case where the entire powder composition is considered as 100% by mass.

11. The composition according to claim 1, wherein the cellulose is crystalline cellulose.

12. The composition according to claim 1, further comprising (D) lysine or a salt thereof.

13. The composition according to claim 12, wherein a content of the (D) is 0.0001 to 1% by mass in the case where the entire powder composition is considered as 100% by mass.

14. The composition according to claim 1, wherein a median diameter of a number-based distribution of the acyllysine is 4 μm or less.

15. The composition according to claim 1, wherein the median diameter of the volume-based distribution of the acyllysine is 6 μm or less.

16. The composition according to claim 1, wherein the median diameter of the number-based distribution of the acyllysine is 2 μm or less.

17. The composition according to claim 1, wherein the median diameter of the volume-based distribution of the acyllysine is 4 μm or less.

18. The composition according to claim 1, wherein a bulk density of the acyllysine is 0.38 g/mL or less.

19. A cosmetic or skin topical agent comprising the composition according to claim 1.

20. A method for producing the composition according to claim 1, comprising the steps of: introducing (A) acyllysine and (B) cellulose and/or starch; and mixing.

21. A method for producing the composition according to claim 9, comprising the steps of: introducing (A) acyllysine, (B) cellulose and/or starch, and (C) silica; and mixing.

22. The production method according to claim 20, wherein the mixing includes mixing through dry mixing.

23. The production method according to claim 20, wherein the mixing includes mixing for 120 minutes or less by using a mixer.

Description

EXAMPLES

[0118] Method for Measuring Various Particle Diameters of Acyllysin:

[0119] A particle diameter distribution was measured from a volume cumulative value by using a laser diffraction/scattering particle diameter distribution measuring device (Partica LA-950 manufactured by HORIBA). Results obtained by the measurement were analyzed by using software attached to the device to obtain various particle diameters of number-based distribution and volume-based distribution. 20 mg of acyllysine was added to 5 g of isopropyl alcohol, and was exposed to an ultrasonic wave while agitating for 30 minutes to be disintegrated and dispersed by using an ultrasonic wave device having an output of 300 Watt. An appropriate amount of this dispersion liquid was added to 500 mL of isopropyl alcohol in accordance with the procedure of the device, and a dispersion sample having an appropriate concentration was prepared while checking the transparency. While this sample was being circulated at a flow rate of 10 mL/min, an ultrasonic wave was applied to the sample for 30 minutes to disperse the sample into primary particles. After deaeration, the particle diameter distribution and various particle diameters of acyllysine in the sample were obtained by using a flow cell.

[0120] Method for Measuring Bulk Density of Acyllysine:

[0121] Lauroyl lysine was agitated for 2 minutes or more by using a mixer to be disintegrated. The bulk density of the crystal thus obtained was measured by using powder rheometer FT-4 (manufactured by Freeman Technology™). Specifically, a certain amount of lauroyl lysine was measured and taken in a holder, and then conditioning was conducted in accordance with the utilization procedure. From the volume and mass of lauroyl lysine after the conditioning, the bulk density was measured in accordance with the following formula.

the Bulk Density=the Mass after the Conditioning/the Volume after the Conditioning (g/mL)

Preparation of Acyllysine

(Acyllysine of Preparation Example A)

[0122] After 5.7 g of sodium hydroxide was dissolved into a mixed solution of 97.4 g of methanol and 62.7 g of water at room temperature, the mixture was heated to about 50° C. Then, 36.4 g of a commercially-available Nε-lauroyl lysine crystal was added thereto, and was dissolved at the same temperature to obtain a solution of Nε-lauroyl lysine. Thereafter, the solution of Nε-lauroyl lysine was added dropwise over 75 minutes into an aqueous solution of hydrochloric acid (600 mL) having a concentration of 0.1 mol/L, which was kept being cooled to 30° C. or less while the pH was maintained at 0.7 to 1.3. After the completion of the dropwise addition, the pH was adjusted to 7.0 with sodium hydroxide, and the prepared crystal was filtrated and dried under reduced pressure to obtain 36.0 g of a white crystal. The median diameter of the volume-based distribution of the crystal thus obtained was 9 μm.

[0123] Note that Nε-lauroyl lysine having a smaller median diameter of the volume-based distribution can be obtained by lowering the temperature of the aqueous solution of hydrochloric acid to which the solution of Nε-lauroyl lysine is added dropwise.

Acyllysine of Preparation Example 1

[0124] A white crystal of Nε-lauroyl lysine having a median diameter of the volume-based distribution of 3.9 μm, a median diameter of the number-based distribution of 1.1 μm, and a bulk density of 0.28 g/mL was obtained by appropriately changing the temperature of the aqueous solution of hydrochloric acid to which the solution of Nε-lauroyl lysine was added dropwise, in accordance with Preparation Example A.

Acyllysine of Preparation Example 2

[0125] A white crystal of Nε-lauroyl lysine having a median diameter of the volume-based distribution of 4.4 μm was obtained by appropriately changing the temperature of the aqueous solution of hydrochloric acid to which the solution of Nε-lauroyl lysine was added dropwise, in accordance with Preparation Example A.

Acyllysine of Preparation Example 3

[0126] A white crystal of Nε-lauroyl lysine having a median diameter of the volume-based distribution of 5.7 μm and a median diameter of the number-based distribution of 3.5 μm was obtained by appropriately changing the temperature of the aqueous solution of hydrochloric acid to which the solution of Nε-lauroyl lysine was added dropwise, in accordance with Preparation Example A.

Acyllysine of Preparation Example 4

[0127] A white crystal of Nε-lauroyl lysine having a median diameter of the volume-based distribution of 6.1 μm was obtained by appropriately changing the temperature of the aqueous solution of hydrochloric acid to which the solution of Nε-lauroyl lysine was added dropwise, in accordance with Preparation Example A.

Acyllysine of Preparation Example 5

[0128] A white crystal of Nε-lauroyl lysine having a median diameter of the volume-based distribution of 9.0 μm was obtained by appropriately changing the temperature of the aqueous solution of hydrochloric acid to which the solution of Nε-lauroyl lysine was added dropwise, in accordance with Preparation Example A.

Acyllysine of Preparation Example 6

[0129] Nε-lauroyl lysine was obtained by milling commercially-available Nε-lauroyl lysine (produced by Ajinomoto Co., Inc. under the trade name of AMIHOPE LL) by using Picoline (swirling jet mill) of Hosokawa Micron Corporation with a supply gas pressure of 0.60 MPa, a milling gas pressure of 0.60 MPa, and a supply rate of 49.3 g/h. The median diameter of the volume-based distribution of the Nε-lauroyl lysine thus obtained was 3.2 μm.

Acyllysine of Preparation Example 7

[0130] A white crystal of Nε-lauroyl lysine having a median diameter of the volume-based distribution of 2.2 μm was obtained by appropriately changing the temperature of the aqueous solution of hydrochloric acid to which the solution of Nε-lauroyl lysine was added dropwise, in accordance with Preparation Example A.

Acyllysine of Preparation Example 8

[0131] A white crystal was obtained in accordance with Production Example 4 of WO01/014317. As a result of conducting various measurements on the crystal thus obtained, the median diameter of the volume-based distribution of the obtained Nε-lauroyl lysine was 14 μm.

Sensory Evaluation Method:

[0132] Hearing investigations were conducted to 5 expert panelists for 5 evaluation items, namely, smoothness, moistness, ball-bearing effect, adhesiveness to the skin, and softness. The score of Comparison Control was deemed as 5, and a score was given to each of the evaluation items in accordance with the following methods, and the score of the evaluation item was determined with an average score of the 5 panelists. Furthermore, evaluation was determined in accordance with a 5-scale of A to E with an average value of the scores of each evaluation item.

(Score): (Evaluation)

6: Very Good

5: Good

4: Slightly Good

3: Slightly Poor

2: Poor

1: Very Poor

(Determination): (Score Average Value)

[0133] A: 5.0 or more

B: 4.4 to 4.9

C: 3.9 to 4.3

D: 3.1 to 3.8

[0134] E: 3.0 or less

Examples 1-1 to 1-7 and Comparative Examples 1-1 to 1-2

[0135] Raw materials were weighed in a blending ratio (% by mass) shown in Table 1 such that the total weight was 5.0 g, and all the raw materials were simultaneously introduced into Labo Milser (TESCOM Mill & Mixer TML162). An evaluation sample was obtained by mixing the raw materials for 100 seconds (five times each for 20 seconds, the powder attached to the inner wall surface was scraped off between mixing processes). Evaluation results when nylon (produced by Toray Industries, Inc., SP-500) was used as Comparison Control are shown in Table 1. The score of each evaluation item is shown in Table 2-1.

TABLE-US-00001 TABLE 1 Example Example Example Example Example Example Example Comparative Comparative 1-1 1-2 1-3 1-4 1-5 1-6 1-7 Example 1-1 Example 1-2 Acyllysine of 10 Preparation Example 1 Acyllysine of 10 Preparation Example 2 Acyllysine of 10 Preparation Example 3 Acyllysine of 10 Preparation Example 4 Acyllysine of 10 Preparation Example 5 Acyllysine of 10 Preparation Example 6 Acyllysine of 10 Preparation Example 7 Acyllysine of 10 Preparation Example 8 Acyllysine of 10 Comparative Example *4 Porous spherical 60 60 60 60 60 60 60 60 60 silica *1 Plate-shaped 30 30 30 30 30 30 30 30 30 cellulose *2 Sensory A B B C C A A E E evaluation

TABLE-US-00002 TABLE 2-1 Ball-bearing Adhesiveness Smoothness Moistness effect to the skin Softness Total Example 1-1 4.6 5.6 5.2 5.8 5.0 5.2 Example 1-2 4.0 5.4 4.8 5.4 5.0 4.9 Example 1-3 3.6 5.2 4.8 5.0 4.6 4.6 Example 1-4 3.6 4.8 4.4 4.8 4.0 4.3 Example 1-5 3.5 4.6 4.0 4.7 4.0 4.2 Example 1-6 4.7 5.4 5.2 5.8 5.0 5.2 Example 1-7 4.6 5.6 5.4 5.8 5.0 5.3 Comparative 3.4 3.0 2.1 3.3 3.1 3.0 Example 1-1 Comparative 3.4 2.8 2.0 3.2 3.2 2.9 Example 1-2

[0136] A water repellent time was evaluated for the evaluation samples. The evaluation method was such that 5 g of an aqueous solution of 30% by mass or 35% by mass of ethanol was put in a 10-mL glass vial, and 30 mg of each evaluation sample was gradually introduced from above, and the time for which the evaluation sample remained on the liquid surface was measured as the water repellent time. Evaluation results are shown in Table 2-2.

TABLE-US-00003 TABLE 2-2 Example Example Example Example Example Example Example Comparative 1-7 1-6 1-1 1-2 1-3 1-4 1-5 Example 1-2 Median diameter of the 2.2 3.2 3.9 4.4 5.7 6.1 9.0 20 volume-based distribution of acyllysine (μm) Water repellent time 60 60 60 60 43 43 38 5 (35% ethanol) minutes minutes minutes minutes minutes minutes minutes minutes or more or more or more or more Water repellent time 60 60 60 60 60 60 60 9 (30% ethanol) minutes minutes minutes minutes minutes minutes minutes minutes or more or more or more or more or more or more or more

Examples 2-1 to 2-12 and Comparative Examples 2-1 to 2-4

[0137] Raw materials were weighed in a blending ratio (% by mass) shown in Table 3-1 to Table 3-3 such that the total weight was 5.0 g, and all the raw materials were simultaneously introduced into Labo Milser (TESCOM Mill & Mixer TML162). An evaluation sample was obtained by mixing the raw materials for 100 seconds (five times each for 20 seconds, the powder attached to the inner wall surface was scraped off between mixing processes). Evaluation results when nylon (produced by Toray Industries, Inc., SP-500) was used as Comparison Control are shown in Table 3-1 to Table 3-3.

TABLE-US-00004 TABLE 3-1 Exam- Exam- Exam- Exam- Exam- ple ple ple ple ple 2-1 2-2 2-3 2-4 2-5 Acyllysine of Preparation 8 3 30 8 8 Example 1 Plate-shaped cellulose *2 28 12 13 5 62 Starch *5 Porous spherical silica *1 64 85 57 87 30 Sensory evaluation A A A A A

TABLE-US-00005 TABLE 3-2 Exam- Exam- Exam- Exam- Exam- ple ple ple ple ple 2-6 2-7 2-8 2-9 2-10 Acyllysine of Preparation 8 8 9 5 2 Example 1 Plate-shaped cellulose *2 82 Starch *5 5 27 40 83 Porous spherical silica *1 10 87 64 55 15 Sensory evaluation C B A B C

TABLE-US-00006 TABLE 3-3 Example Example Comparative Comparative Comparative Comparative 2-11 2-12 Example 2-1 Example 2-2 Example 2-3 Example 2-4 Acyllysine of 2 2 8 1 1 8 Preparation Example 1 Plate-shaped 9 12 1 9 5 cellulose *2 Starch *5 94 2 Porous 89 86 91 90 90 spherical silica *1 Sensory C B D D D D evaluation

Examples 3-1 to 3-3

[0138] Raw materials were weighed in a blending ratio (% by mass) shown in Table 4 such that the total weight was 5.0 g, and all the raw materials were simultaneously introduced into Labo Milser (TESCOM Mill & Mixer TML162). An evaluation sample was obtained by mixing the raw materials for 100 seconds (five times each for seconds, the powder attached to the inner wall surface was scraped off between mixing processes). Evaluation results when nylon (produced by Toray Industries, Inc., SP-500) was used as Comparison Control are shown in Table 4.

TABLE-US-00007 TABLE 4 Example Example Example Example 2-1 3-1 3-2 3-3 Acyllysine of Preparation 8 8 8 8 Example 1 Plate-shaped cellulose *2 28 28 28 28 Starch *5 Porous spherical silica *1 64 Porous spherical silica *6 64 Nonporous spherical 64 silica *7 Nonporous spherical 64 silica *8 Sensory evaluation A B A A

Examples 4-1 to 4-11

[0139] Raw materials were weighed in a blending ratio (% by mass) shown in Table 5-1 and Table 5-2 such that the total weight was 5.0 g, and all the raw materials were simultaneously introduced into Labo Milser (TESCOM Mill & Mixer TML162). An evaluation sample was obtained by mixing the raw materials for 100 seconds (five times each for 20 seconds, the powder attached to the inner wall surface was scraped off between mixing processes). Evaluation results when nylon (produced by Toray Industries, Inc., SP-500) was used as Comparison Control are shown in Tables 5-1 and 5-2.

TABLE-US-00008 TABLE 5-1 Example Example Example Example Example Example 2-1 4-1 4-2 4-3 4-4 4-5 Acyllysine of Preparation 8 8 8 8 8 8 Example 1 Plate-shaped cellulose *2 28 5 Plate-shaped cellulose *9 28 Plate-shaped cellulose *10 28 Spherical cellulose *11 28 Spherical cellulose *12 28 Starch *5 87 Porous spherical silica *1 64 64 64 64 64 Sensory evaluation A A A A A A

TABLE-US-00009 TABLE 5-2 Example Example Example Example Example Example 4-6 4-7 4-8 4-9 4-10 4-11 Acyllysine of Preparation 8 8 8 8 8 8 Example 1 Plate-shaped cellulose *2 1 Plate-shaped cellulose *9 5 Plate-shaped cellulose *10 5 Spherical cellulose *11 5 Spherical cellulose *12 5 1 Starch *5 87 87 87 87 91 91 Porous spherical silica *1 Sensory evaluation A A A A B B

Examples 5-1 to 5-4

[0140] Raw materials were weighed in a blending ratio (% by mass) shown in Table 6-1 and Table 6-2 such that the total weight was 5.0 g, and all the raw materials were simultaneously introduced into Labo Milser (TESCOM Mill & Mixer TML162). An evaluation sample was obtained by mixing the raw materials for 100 seconds (five times each for 20 seconds, the powder attached to the inner wall surface was scraped off between mixing processes). Evaluation results when PMMA particles (produced by Matsumoto Yushi-Seiyaku Co., Ltd.: Matsumoto Microsphere M-100) were used as Comparison Control are shown in Table 6-1 and Table 6-2.

TABLE-US-00010 TABLE 6-1 Example Example Example 2-8 5-1 5-2 Acyllysine of Preparation 9 9 9 Example 1 Plate-shaped cellulose *2 Starch *5 27 Starch *14 27 Starch *15 27 Porous spherical silica *1 64 64 64 Sensory evaluation A A A

TABLE-US-00011 TABLE 6-2 Example Example Example 4-5 5-3 5-4 Acyllysine of Preparation 8 8 8 Example 1 Plate-shaped cellulose *2 5 5 5 Starch *5 87 Starch *14 87 Starch *15 87 Porous spherical silica *1 Sensory evaluation A A A

Examples 6-1 to 6-14

[0141] Raw materials were weighed in a blending ratio (% by mass) shown in Table 7-1 to Table 7-3 such that the total weight was 5.0 g, and all the raw materials were simultaneously introduced into Labo Milser (TESCOM Mill & Mixer TML162). An evaluation sample was obtained by mixing the raw materials for 100 seconds (five times each for 20 seconds, the powder attached to the inner wall surface was scraped off between mixing processes). Evaluation results when urethane particles (produced by DAINICHISEIKA COLOR & CHEM MFG CO., LTD.: DAIMIC BEAZ) were used as Comparison Control are shown in Table 7-1 to Table 7-3.

TABLE-US-00012 TABLE 7-1 Example Example Example Example 6-1 6-2 6-3 6-4 Acyllysine of Preparation 5 10 15 30 Example 1 Plate-shaped cellulose *2 Spherical cellulose *12 95 90 85 70 Starch *5 Sensory evaluation A A A A

TABLE-US-00013 TABLE 7-2 Exam- Exam- Exam- Exam- Exam- ple ple ple ple ple 6-5 6-6 6-7 6-8 6-9 Acyllysine of Preparation 15 15 15 15 15 Example 1 Plate-shaped cellulose *2 85 35 55 Spherical cellulose *12 50 30 30 15 Starch *5 55 70 Sensory evaluation C B C A A

TABLE-US-00014 TABLE 7-3 Exam- Exam- Exam- Exam- Exam- ple ple ple ple ple 6-10 6-11 6-12 6-13 6-14 Acyllysine of Preparation 10 5 15 5 2 Example 1 Plate-shaped cellulose *2 34 Spherical cellulose *12 15 15 50 5 5 Starch *5 75 80 90 93 Lysine hydrochloride 1 Sensory evaluation A B A B C

Examples 7-1 to 7-4

[0142] Raw materials were weighed in a blending ratio (% by mass) shown in Table 8 such that the total weight was 5.0 g, and all the raw materials were simultaneously introduced into Labo Milser (TESCOM Mill & Mixer TML162). An evaluation sample was obtained by mixing the raw materials for 100 seconds (five times each for seconds, the powder attached to the inner wall surface was scraped off between mixing processes).

[0143] The non-dryness at the time of applying various mixtures was evaluated by 5 expert panelists in accordance with the following criteria.

[0144] Method for Evaluating Dryness at the Time of Application: [0145] 1) There is no feeling of dryness at the time of application . . . . 4 points [0146] 2) There hardly is feeling of dryness at the time of application . . . . 3 points [0147] 3) There is little feeling of dryness at the time of application . . . . 2 points [0148] 4) There is feeling of dryness at the time of application . . . . 1 point

[0149] Determination was made as follows based on average scores of evaluation of the 5 expert panelists. Results are shown in Table 14.

[0150] Average score of evaluation 3.5 or more: Very favorable (A) Average score of evaluation 2.5 or more and less than 3.5: Slightly favorable (B)

[0151] Average score of evaluation 1.5 or more and less than 2.5: Not so favorable (C)

[0152] Average score of evaluation and less than 1.5: Not favorable at all (D)

TABLE-US-00015 TABLE 8 Example Example Example Example 7-1 7-2 7-3 7-4 Acyllysine of Preparation 8 8 8 8 Example 1 Plate-shaped cellulose *2 5 5 Starch *5 5 5 87 86.99 Spherical silica *1 87 86.5 Lysine hydrochloride 0.5 0.01 Dryness at the time of B A B A application

[0153] Raw materials: Raw materials used in Examples and Comparative Examples shown in Table 1 to Table 8 described above are as follows.

*1 produced by AGC Si-Tech Co., Ltd.: average particle diameter 5 μm
*2 produced by Evonik Operations (TEGO Feel): average particle diameter 30 μm
*4 produced by Ajinomoto Co., Inc., AMIHOPE LL: median diameter of the volume-based distribution 20 μm
*5 produced by NIPPON STARCH CHEMICAL CO., LTD. (ST starch C(W)): average particle diameter 18 μm
*6 produced by AGC Si-Tech Co., Ltd.: average particle diameter 12 μm
*7 produced by AGC Si-Tech Co., Ltd.: average particle diameter 4 μm
*8 produced by AGC Si-Tech Co., Ltd.: average particle diameter 10 μm
*9 produced by Evonik Operations: average particle diameter 10 μm
*10 average particle diameter: 20 μm, bulk density 0.22 g/cm.sup.3
*11 produced by DAITO KASEI KOGYO CO., LTD.: average particle diameter 5 μm
*12 produced by DAITO KASEI KOGYO CO., LTD.: average particle diameter 10 μm
*14 produced by DAITO KASEI KOGYO CO., LTD. (RICE PW): average particle diameter 8 μm
*15 produced by NIPPON STARCH CHEMICAL CO., LTD. (ST starch P): average particle diameter 32 μm

Production Examples 1 to 4

[0154] Production Examples of the powder composition of the present invention are shown below.

Production Example 1

[0155] By using a Henschel mixer (Nippon Coke & Engineering Co., Ltd. FM mixer FM150), 15.0 kg of silica, 7.5 kg of crystalline cellulose, and 2.5 kg of Nε-lauroyl lysine (having a median diameter of the volume-based distribution of 3.9 μm) are weighed, and simultaneously introduced into the mixer (the total amount of the powder: kg). The powder is mixed with the circumferential speed of the agitating blade being 60 m/sec for 30 minutes.

Production Example 2

[0156] By using a agitating and mixing granulator (Powrex Corp. Vertical Granulator VG-200), 15.0 kg of silica, 7.5 kg of crystalline cellulose, and 2.5 kg of Nε-lauroyl lysine (having a median diameter of the volume-based distribution of 3.9 μm) are weighed, and simultaneously introduced into the mixer (the total amount of the powder: kg). The powder is mixed with a blade rotational speed of: 100 rpm and a cross-screw rotational speed of: 1800 rpm for a mixing time of 60 minutes.

Production Example 3

[0157] By using a agitating and mixing granulator (EARTHTECHNICA Co., Ltd. high speed mixer LFS2), 120 g of silica, 60 g of crystalline cellulose, and 20 g of lauroyl lysine (having a median diameter of the volume-based distribution of 3.9 μm) are weighed, and simultaneously introduced into the mixer (the total amount of the powder: 200 g). The powder is mixed with a blade rotational speed of: 500 rpm and a chopper rotational speed of: 2000 rpm for a mixing time of 60 minutes.

Production Example 4

[0158] By using a agitating and mixing granulator (EARTHTECHNICA Co., Ltd. high speed mixer LFS2), 120 g of silica, 60 g of crystalline cellulose, and 20 g of octanoyl lysine (having a median diameter of the volume-based distribution of 8.8 μm) are weighed, and simultaneously introduced into the mixer (the total amount of the powder: 200 g). The powder is mixed with a blade rotational speed of: 500 rpm and a chopper rotational speed of: 2000 rpm for a mixing time of 60 minutes.

(Evaluation Using Pressed Foundation)

[0159] As cosmetics or skin topical agents using the powder compositions of the present invention, pressed foundations were prepared, and were evaluated.

[0160] Regarding the evaluation on the usability, 5 expert panelists gave scores to 4 evaluation items, namely, “adhesion”, “smoothness on application”, “non-stickiness”, and “moisturization”, and the score of each evaluation item was determined using an average score of the 5 panelists. Furthermore, evaluation was determined in accordance with a 5-scale of A to D with an average value of the scores of each evaluation item.

(Score): (Evaluation)

6: Very Good

5: Good

4: Slightly Good

3: Slightly Poor

2: Poor

1: Very Poor

[0161] (Determination):(Score average value)
A: 5 points or more
B: 4 points or more and less than 5 points
C: 3 points or more and less than 4 points
D: less than 3 points

Examples 8

[0162] Pressed foundations were prepared by using components shown in Table 9-1 and Table 9-2 as follows. B was heated and dissolved. A was weighed and mixed by using Labo Milser for 30 seconds. B was added to A, and further agitated by using Labo Mixer for 5 minutes, and mixed 30 seconds x three times by using Labo Milser. The mixture was sieved by using a 150-μm opening sieve to make the particle diameters uniform, and the mixture was then packed in a gold plate and compression-molded.

TABLE-US-00016 TABLE 9-1 Comparative Example Example Example Example Example Example 8-3 8-1 8-2 8-3 8-4 8-5 Example No. of the powder Comparative Comparative Comparative Example Example Example Example Example composition of the present Example 8-1 Example 8-2 Example 2-2 2-1 2-4 2-5 2-7 2-8 invention described below (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) A Talc, dimethicone *1 20.40 20.40 20.40 20.40 20.40 20.40 20.40 20.40 Mica, dimethicone *2 30.00 30.00 30.00 30.00 30.00 30.00 30.00 30.00 Mica, dimethicone *3 20.00 20.00 20.00 20.00 20.00 20.00 20.00 20.00 Titanium oxide, dimethicone *4 8.00 8.00 8.00 8.00 8.00 8.00 8.00 8.00 Titanium oxide, Al stearate *5 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 Zinc oxide, methicone *6 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Red iron oxide, dimethicone *7 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 Yellow iron oxide, dimethicone *8 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Black iron oxide, dimethicone *9 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Nylon-12 *10 4.00 — — — — — — — PMMA particles — 4.00 — — — — — — Urethane particles — — — — — — — — The powder composition of the — — 4.00 4.00 4.00 4.00 4.00 4.00 present invention Methylparaben 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 B Dimethicone *11 4.98 4.98 4.98 4.98 4.98 4.98 4.98 4.98 Polyglyceryl-2 tetraisostearate *12 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 Dipentaerythrityl 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 hexahydroxystearate/hexastearate/ hexarosinate *13 Mineral oil *14 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Methylparaben 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 Tocopherol 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 Total 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 Sensory evaluation A A C A A A B A

TABLE-US-00017 TABLE 9-2 Example Example Example Example Example Example Example 8-6 8-7 8-8 8-9 8-10 8-11 8-12 Example No. of the powder Example Example Example Example Example Example Example composition of the present 2-11 3-1 3-3 4-1 4-4 4-10 5-1 invention described below (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) A Talc, dimethicone *1 20.40 20.40 20.40 20.40 20.40 20.40 20.40 Mica, dimethicone *2 30.00 30.00 30.00 30.00 30.00 30.00 30.00 Mica, dimethicone *3 20.00 20.00 20.00 20.00 20.00 20.00 20.00 Titanium oxide, dimethicone *4 8.00 8.00 8.00 8.00 8.00 8.00 8.00 Titanium oxide, Al stearate *5 3.00 3.00 3.00 3.00 3.00 3.00 3.00 Zinc oxide, methicone *6 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Red iron oxide, dimethicone *7 0.40 0.40 0.40 0.40 0.40 0.40 0.40 Yellow iron oxide, dimethicone *8 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Black iron oxide, dimethicone *9 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Nylon-12 *10 — — — — — — — PMMA particles — — — — — — — Urethane particles — — — — — — — The powder composition of the 4.00 4.00 4.00 4.00 4.00 4.00 4.00 present invention Methylparaben 0.05 0.05 0.05 0.05 0.05 0.05 0.05 B Dimethicone *11 4.98 4.98 4.98 4.98 4.98 4.98 4.98 Polyglyceryl-2 tetraisostearate *12 3.00 3.00 3.00 3.00 3.00 3.00 3.00 Dipentaerythrityl 1.00 1.00 1.00 1.00 1.00 1.00 1.00 hexahydroxystearate/hexastearate/ hexarosinate *13 Mineral oil *14 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Methylparaben 0.01 0.01 0.01 0.01 0.01 0.01 0.01 Tocopherol 0.01 0.01 0.01 0.01 0.01 0.01 0.01 Total 100.0 100.0 100.0 100.0 100.0 100.0 100.0 Sensory evaluation A B A A A B A
Table 9-1 to Table 9-2 described above are as follows.
*1 SA-Talc JA-46R, produced by Miyoshi Kasei Inc.
*2 SA-Sericite FSE, produced by Miyoshi Kasei Inc.
*3 SA-Mica Y-2300, produced by Miyoshi Kasei Inc.
*4 SA-Ttitanium CR50 (100%), produced by Miyoshi Kasei Inc.
*5 MT-100Z, produced by Tayca Corporation
*6 MZ-303S, produced by Tayca Corporation
*7 SA-Red R-516PS (100%), produced by Miyoshi Kasei Inc.
*8 SA-Yellow LL-100P (100%), produced by Miyoshi Kasei Inc.
*9 SA-Black BL-100PS (100%), produced by Miyoshi Kasei Inc.
*10 SP-500, produced by Toray Industries, Inc.
*11 KF-96A-20cs, produced by Shin-Etsu Chemical Co., Ltd.
*12 Cosmol 44V, produced by The Nisshin OilliO Group, Ltd.
*13 Cosmol 168ARV, produced by The Nisshin OilliO Group, Ltd.
*14 Hycol K-230, produced by Kaneda Co.,Ltd.

Examples 9

[0163] Pressed foundations were prepared by using components shown in Table 10-1 and Table 10-2 as follows. B was heated and dissolved. A was weighed and mixed by using Labo Milser for 30 seconds. B was added to A, and further agitated by using Labo Mixer for 5 minutes, and mixed for 30 seconds x three times by using Labo Milser. The mixture was sieved by using a 150-μm opening sieve to make the particle diameters uniform, and the mixture was then packed in a gold plate and compression-molded.

[0164] Examples 9-1 to 9-10 had better moldability than Comparative Examples 9-1 to 9-4, and also prescriptions excellent in scoopability were obtained.

TABLE-US-00018 TABLE 10-1 Example Example Example 9-1 9-2 9-3 Example No. of the powder Comparative Comparative Comparative Comparative Example Example Example composition of the present Example 9-1 Example 9-2 Example 9-3 Example 9-4 2-1 2-1 2-1 invention described below (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) A Talc, dimethicone *1 21.40 15.40 21.40 15.40 21.40 20.90 18.40 Mica, dimethicone *2 31.00 24.00 31.00 24.00 31.00 30.50 28.00 Mica, dimethicone *3 21.00 15.00 21.00 15.00 21.00 20.00 18.00 Titanium oxide, dimethicone *4 8.00 8.00 8.00 8.00 8.00 8.00 8.00 Titanium oxide, Al stearate *5 3.00 3.00 3.00 3.00 3.00 3.00 3.00 Zinc oxide, methicone *6 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Red iron oxide, dimethicone *7 0.40 0.40 0.40 0.40 0.40 0.40 0.40 Yellow iron oxide, dimethicone *8 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Black iron oxide, dimethicone *9 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Nylon-12 *10 1.00 20.00 — — — — — PMMA particles — — 1.00 20.00 — — — Urethane particles — — — — — — — The powder composition of the — — — — 1.00 3.00 10.00 present invention Methylparaben 0.05 0.05 0.05 0.05 0.05 0.05 0.05 B Dimethicone *11 4.98 4.98 4.98 4.98 4.98 4.98 4.98 Polyglyceryl-2 tetraisostearate *12 3.00 3.00 3.00 3.00 3.00 3.00 3.00 Dipentaerythrityl 1.00 1.00 1.00 1.00 1.00 1.00 1.00 hexahydroxystearate/hexastearate/ hexarosinate *13 Mineral oil *14 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Methylparaben 0.01 0.01 0.01 0.01 0.01 0.01 0.01 Tocopherol 0.01 0.01 0.01 0.01 0.01 0.01 0.01 Total 100.0 100.0 100.0 116.0 100.0 100.0 100.0 Sensory evaluation C A C A C A A

TABLE-US-00019 TABLE 10-2 Example Example Example Example Example Example Example 9-4 9-5 9-6 9-7 9-8 9-9 9-10 Example No. of the powder Example Example Example Example Example Example Example composition of the present 2-1 2-1 2-10 2-10 2-10 2-10 2-10 invention described below (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) A Talc, dimethicone *1 15.40 13.90 21.40 20.90 18.40 15.40 13.90 Mica, dimethicone *2 24.00 17.00 31.00 30.50 28.00 24.00 17.00 Mica, dimethicone *3 15.00 13.50 21.00 20.00 18.00 15.00 13.50 Titanium oxide, dimethicone *4 8.00 8.00 8.00 8.00 8.00 8.00 8.00 Titanium oxide, Al stearate *5 3.00 3.00 3.00 3.00 3.00 3.00 3.00 Zinc oxide, methicone *6 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Red iron oxide, dimethicone *7 0.40 0.40 0.40 0.40 0.40 0.40 0.40 Yellow iron oxide, dimethicone *8 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Black iron oxide, dimethicone *9 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Nylon-12 *10 — — — — — — — PMMA particles — — — — — — — Urethane particles — — — — — — — The powder composition of the 20.00 30.00 1.00 3.00 10.00 20.00 30.00 present invention Methylparaben 0.05 0.05 0.05 0.05 0.05 0.05 0.05 B Dimethicone *11 4.98 4.98 4.98 4.98 4.98 4.98 4.98 Polyglyceryl-2 tetraisostearate *12 3.00 3.00 3.00 3.00 3.00 3.00 3.00 Dipentaerythrityl 1.00 1.00 1.00 1.00 1.00 1.00 1.00 hexahydroxystearate/hexastearate/ hexarosinate *13 Mineral oil *14 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Methylparaben 0.01 0.01 0.01 0.01 0.01 0.01 0.01 Tocopherol 0.01 0.01 0.01 0.01 0.01 0.01 0.01 Total 100.0 100.0 100.0 100.0 100.0 100.0 100.0 Sensory evaluation A C C A A A C
Table 10-1 to Table 10-2 described above are as follows.
*1 SA-Talc JA-46R, produced by Miyoshi Kasei Inc.
*2 SA-Sericite FSE, produced by Miyoshi Kasei Inc.
*3 SA-Mica Y-2300, produced by Miyoshi Kasei Inc.
*4 SA-Ttitanium CR50 (100%), produced by Miyoshi Kasei Inc.
*5 MT-100Z, produced by Tayca Corporation
*6 MZ-303S, produced by Tayca Corporation
*7 SA-Red R-516PS (100%), produced by Miyoshi Kasei Inc.
*8 SA-Yellow LL-100P (100%), produced by Miyoshi Kasei Inc.
*9 SA-Black BL-100PS(100%), produced by Miyoshi Kasei Inc.
*10 SP-500, produced by Toray Industries, Inc.
*11 KF-96A-20cs, produced by Shin-Etsu Chemical Co., Ltd.
*12 Cosmol 44V, produced by The Nisshin OilliO Group, Ltd.
*13 Cosmol 168ARV, produced by The Nisshin OilliO Group, Ltd.
*14 Hycol K-230, produced by Kaneda Co.,Ltd.

(Evaluation Using Liquid Foundation)

[0165] As cosmetics or skin topical agents using the powder compositions of the present invention, liquid foundations were prepared, and were evaluated.

[0166] Regarding the evaluation on the usability, 5 expert panelists gave scores to 4 evaluation items, namely, “adhesion”, “smoothness on application”, “non-stickiness”, “moisturization”, and the score of each evaluation item was determined using an average score of the 5 panelists. Furthermore, evaluation was determined in accordance with a 5-scale of A to D with an average value of the scores of each evaluation item.

(Score):(Evaluation)

6: Very Good

5: Good

4: Slightly Good

3: Slightly Poor

2: Poor

1: Very Poor

(Determination): (Score Average Value)

[0167] A: 5 points or more
B: 4 points or more and less than 5 points
C: 3 points or more and less than 4 points
D: less than 3 points

Examples 10

[0168] Liquid foundations were prepared by using components shown in Table 11-1 and Table 11-2 as follows.

[0169] A was heated (75° C.) and mixed (4000 rpm) by using a homo-mixer. B was added to A, followed by heating (75° C.) and mixing (4000 rpm) by using the homo-mixer. Moreover, C was added to A, followed by heating (75° C.) and mixing (4000 rpm) by using the homo-mixer. D was heated to 75° C. and dissolved, and was gradually added to A to be emulsified. Thereafter, the mixture was cooled down to 30° C. while being agitated with a paddle.

TABLE-US-00020 TABLE 11-1 Comparative Example Example Example Example Example Example 10-3 10-1 10-2 10-3 10-4 10-5 Example No. of the powder Comparative Comparative Comparative Example Example Example Example Example composition of the present Example 10-1 Example 10-2 Example 2-2 2-1 2-4 2-5 2-7 2-8 invention described below (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) A DC246 *1 24.44 24.44 24.44 24.44 24.44 24.44 24.44 24.44 Squalane 2.04 2.04 2.04 2.04 2.04 2.04 2.04 2.04 ELDEW ® PS-203 *2 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 Isotridecyl 5.09 5.09 5.09 5.09 5.09 5.09 5.09 5.09 isononanoate *3 Polyglyceryl-2 2.04 2.04 2.04 2.04 2.04 2.04 2.04 2.04 diisostearate *4 PEG-10 Dimethicone 2.80 2.80 2.80 2.80 2.80 2.80 2.80 2.80 *5 Dimethicone *6 2.29 2.29 2.29 2.29 2.29 2.29 2.29 2.29 Phenoxyethanol 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 Tocopherol acetate 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Distearyldimonium 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 chloride *7 B Quaternium-18 9.26 9.26 9.26 9.26 9.26 9.26 9.26 9.26 bentonite, isododecane, isopropylene carbonate *8 C Talc, dimethicone *9 10.56 10.56 10.56 10.56 10.56 10.56 10.56 10.56 Titanium oxide, 3.70 3.70 3.70 3.70 3.70 3.70 3.70 3.70 dimethicone *10 Red iron oxide, 0.19 0.19 0.19 0.19 0.19 0.19 0.19 0.19 dimethicone *11 Yellow iron oxide, 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 dimethicone *12 Black iron oxide, 0.09 0.09 0.09 0.09 0.09 0.09 0.09 0.09 dimethicone *13 Nylon-12 *14 8.00 PMMA particles*15 8.00 The powder 8.00 8.00 8.00 8.00 8.00 8.00 composition of the present invention D EDTA-2Na 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 BG *16 4.63 4.63 4.63 4.63 4.63 4.63 4.63 4.63 Purified water 22.50 22.50 22.50 22.50 22.50 22.50 22.50 22.50 Total 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 Sensory evaluation A A D A A A B A

TABLE-US-00021 TABLE 11-2 Example Example Example Example Example Example Example 10-6 10-7 10-8 10-9 10-10 10-11 10-12 Example No. of the powder Example Example Example Example Example Example Example composition of the present 2-11 3-1 3-3 4-1 4-4 4-10 5-1 invention described below (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) A DC246 *1 24.44 24.44 24.44 24.44 24.44 24.44 24.44 Squalane 2.04 2.04 2.04 2.04 2.04 2.04 2.04 ELDEW ® PS-203 *2 0.51 0.51 0.51 0.51 0.51 0.51 0.51 Isotridecyl isononanoate *3 5.09 5.09 5.09 5.09 5.09 5.09 5.09 Polyglyceryl-2 diisostearate 2.04 2.04 2.04 2.04 2.04 2.04 2.04 *4 PEG-10 dimethicone *5 2.80 2.80 2.80 2.80 2.80 2.80 2.80 Dimethicone *6 2.29 2.29 2.29 2.29 2.29 2.29 2.29 Phenoxyethanol 0.41 0.41 0.41 0.41 0.41 0.41 0.41 Tocopherol acetate 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Distearyldimonium chloride 0.10 0.10 0.10 0.10 0.10 0.10 0.10 *7 B Quaternium-18 bentonite, 9.26 9.26 9.26 9.26 9.26 9.26 9.26 isododecane, isopropylene carbonate *8 C Talc, dimethicone *9 10.56 10.56 10.56 10.56 10.56 10.56 10.56 Titanium oxide, dimethicone 3.70 3.70 3.70 3.70 3.70 3.70 3.70 *10 Red iron oxide, dimethicone 0.19 0.19 0.19 0.19 0.19 0.19 0.19 *11 Yellow iron oxide, 1.20 1.20 1.20 1.20 1.20 1.20 1.20 dimethicone *12 Black iron oxide, 0.09 0.09 0.09 0.09 0.09 0.09 0.09 dimethicone *13 Nylon-12 *14 PMMA particles *15 The powder composition of 8.00 8.00 8.00 8.00 8.00 8.00 8.00 the present invention D EDTA-2Na 0.05 0.05 0.05 0.05 0.05 0.05 0.05 BG *16 4.63 4.63 4.63 4.63 4.63 4.63 4.63 Purified water 22.50 22.50 22.50 22.50 22.50 22.50 22.50 Total 100.00 100.00 100.00 100.00 100.00 100.00 100.00 Sensory evaluation A B A A A B A
Table 11-1 to Table 11-2 described above are as follows.

*1 Cyclohexasiloxane, Cyclopentasiloxane

[0170] *2 produced by Ajinomoto Co., Inc.
*3 EMALEX INTD-139, produced by The Nisshin OilliO Group, Ltd.
*4 EMALEX DISG-2EX, produced by Nihon Emulsion Co., Ltd.
*5 KF-6017P, produced by Shin-Etsu Chemical Co., Ltd.
*6 KF-96A-6T, produced by Shin-Etsu Chemical Co., Ltd.
*7 NIKKOL CA-3475V, produced by Nikko Chemicals Co., Ltd.
*8 BENTON GEL ISD, produced by Elementis
*9 SA-Talc JA-46R, produced by Miyoshi Kasei Inc.
*10 SA-Ttitanium CR50 (100%), produced by Miyoshi Kasei Inc.
*11 SA-Red R-516PS (100%), produced by Miyoshi Kasei Inc.
*12 SA-Yellow LL-100P (100%), produced by Miyoshi Kasei Inc.
*13 SA-Black BL-100PS (100%), produced by Miyoshi Kasei Inc.
*14 SP-500, produced by Toray Industries, Inc.
*15 Matsumoto Microsphere M-100, produced by Matsumoto Yushi-Seiyaku Co., Ltd.
*16 produced by Daicel Corporation

Examples 11

[0171] Liquid foundations were prepared by using components shown in Table 12-1 and Table 12-2 as follows.

[0172] A was heated (75° C.) and mixed (4000 rpm) by using a homo-mixer. B was added to A, followed by heating (75° C.) and mixing (4000 rpm) by using the homo-mixer. Moreover, C was added to A, followed by heating (75° C.) and mixing (4000 rpm) by using the homo-mixer. D was heated to 75° C. and dissolved, and was gradually added to A to be emulsified. Thereafter, the mixture was cooled down to 30° C. while being agitated with a paddle.

TABLE-US-00022 TABLE 12-1 Example Example Example 11-1 11-2 11-3 Example No. of the powder Comparative Comparative Comparative Comparative Example Example Example composition of the present Example 11-1 Example 11-2 Example 11-3 Example 11-4 2-1 2-1 2-1 invention described below (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) A DC246 *1 24.44 20.44 24.44 20.44 24.44 23.44 20.44 Squalane 2.04 2.04 2.04 2.04 2.04 2.04 2.04 ELDEW ® PS-203 0.51 0.51 0.51 0.51 0.51 0.51 0.51 *2 Isotridecyl 5.09 5.09 5.09 5.09 5.09 5.09 5.09 isononanoate *3 Polyglyceryl-2 2.04 2.04 2.04 2.04 2.04 2.04 2.04 diisostearate *4 PEG-10 2.80 2.80 2.80 2.80 2.80 2.80 2.80 dimethicone *5 Dimethicone *6 2.29 2.29 2.29 2.29 2.29 2.29 2.29 phenoxyethanol 0.41 0.41 0.41 0.41 0.41 0.41 0.41 Tocopherol acetate 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Distearyldimonium 0.10 0.10 0.10 0.10 0.10 0.10 0.10 chloride *7 B Quaternium-18 9.26 9.26 9.26 9.26 9.26 9.26 9.26 bentonite, isododecane, isopropylene carbonate *8 C Talc, dimethicone 10.56 10.56 10.56 10.56 10.56 10.56 10.56 *9 Titanium oxide, 3.70 3.70 3.70 3.70 3.70 3.70 3.70 dimethicone *10 Red iron oxide, 0.19 0.19 0.19 0.19 0.19 0.19 0.19 dimethicone *11 Yellow iron oxide, 1.20 1.20 1.20 1.20 1.20 1.20 1.20 dimethicone *12 Black iron oxide, 0.09 0.09 0.09 0.09 0.09 0.09 0.09 dimethicone *13 Nylon-12 *14 1.00 15.00 PMMA particles 1.00 15.00 *15 The powder 1.00 3.00 15.00 composition of the present invention D EDTA-2Na 0.05 0.05 0.05 0.05 0.05 0.05 0.05 BG *16 4.63 4.63 4.63 4.63 4.63 4.63 4.63 Purified water 29.50 19.50 29.50 19.50 29.50 28.50 19.50 Total 100.00 100.00 100.00 100.00 100.00 100.00 100.00 Sensory evaluation C A C A C A A

TABLE-US-00023 TABLE 12-2 Example Example Example Example Example Example Example 11-4 11-6 11-7 11-8 11-9 11-11 11-12 Example No. of the powder Example Example Example Example Example Example Example composition of the present 2-1 2-1 2-10 2-10 2-10 2-10 2-10 invention described below (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) (wt %) A DC246 *1 4.44 24.44 23.44 20.44 4.44 23.44 20.44 Squalane 2.04 2.04 2.04 2.04 2.04 2.04 2.04 ELDEW ® PS-203 *2 0.51 0.51 0.51 0.51 0.51 0.51 0.51 Isotridecyl isononanoate *3 5.09 5.09 5.09 5.09 5.09 5.09 5.09 Polyglyceryl-2 diisostearate 2.04 2.04 2.04 2.04 2.04 2.04 2.04 *4 PEG-10 dimethicone *5 2.80 2.80 2.80 2.80 2.80 2.80 2.80 Dimethicone *6 2.29 2.29 2.29 2.29 2.29 2.29 2.29 Phenoxyethanol 0.41 0.41 0.41 0.41 0.41 0.41 0.41 Tocopherol acetate 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Distearyldimonium chloride 0.10 0.10 0.10 0.10 0.10 0.10 0.10 *7 B Quaternium-18 bentonite, 9.26 9.26 9.26 9.26 9.26 9.26 9.26 isododecane, isopropylene carbonate *8 C Talc, Dimethicone *9 10.56 10.56 10.56 10.56 10.56 10.56 10.56 Titanium oxide, dimethicone 3.70 3.70 3.70 3.70 3.70 3.70 3.70 *10 Red iron oxide, dimethicone 0.19 0.19 0.19 0.19 0.19 0.19 0.19 *11 Yellow iron oxide, 1.20 1.20 1.20 1.20 1.20 1.20 1.20 dimethicone *12 Black iron oxide, 0.09 0.09 0.09 0.09 0.09 0.09 0.09 dimethicone *13 Nylon-12 *14 PMMA particles *15 The powder composition of 40.00 1.00 3.00 15.00 40.00 3.00 15.00 the present invention D EDTA-2Na 0.05 0.05 0.05 0.05 0.05 0.05 0.05 BG *16 4.63 4.63 4.63 4.63 4.63 4.63 4.63 Purified water 10.50 29.50 28.50 19.50 10.50 28.50 19.50 Total 100.00 100.00 100.00 100.00 100.00 100.00 100.00 Sensory evaluation A C C A A A C
Table 12-1 to Table 12-2 described above are as follows.

*1 Cyclohexasiloxane, Cyclopentasiloxane

[0173] *2 produced by Ajinomoto Co., Inc.
*3 EMALEX INTD-139, produced by The Nisshin OilliO Group, Ltd.
*4 EMALEX DISG-2EX, produced by Nihon Emulsion Co., Ltd.
*5 KF-6017P, produced by Shin-Etsu Chemical Co., Ltd.
*6 KF-96A-6T, produced by Shin-Etsu Chemical Co., Ltd.
*7 NIKKOL CA-3475V, produced by Nikko Chemicals Co., Ltd.
*8 BENTON GEL ISD, produced by Elementis
*9 SA-Talc JA-46R, produced by Miyoshi Kasei Inc.
*10 SA-Ttitanium CR50 (100%), produced by Miyoshi Kasei Inc.
*11 SA-Red R-516PS (100%), produced by Miyoshi Kasei Inc.
*12 SA-Yellow LL-100P (100%), produced by Miyoshi Kasei Inc.
*13 SA-Black BL-100PS (100%), produced by Miyoshi Kasei Inc.
*14 SP-500, produced by Toray Industries, Inc.
*15 Matsumoto Microsphere M-100, produced by Matsumoto Yushi-Seiyaku Co., Ltd.
*16 produced by Daicel Corporation

Prescription Example 1

[0174] As cosmetics or skin topical agents using the powder compositions of the present invention, lip cosmetics were prepared by using components shown in Table 13 as follows.

[0175] Components A was heated and dissolved at 105±5° C., and Component B was added to the Component A, and heated and dissolved at 90° C. Moreover, Component C was added, heated and mixed at 90° C., and dispersed by using a triple roll. Then, Component D was added. Component E was added, heated and mixed at 90° C., and then defoaming was conducted. The mixture was put in a mold at a fill temperature of 90° C., and after cooling, was loaded in a container. The lip cosmetic of Prescription Example 1 had little color unevenness, and had good color uniformity. Furthermore, the cosmetic of Prescription Example 1 did not cause perspiration, and had a good stability.

TABLE-US-00024 TABLE 13 Lip cosmetic Blending Names of raw materials amount A Polyethylene wax 2.8 Triethylhexanoin 15 B Candelilla wax 1 Paraffin wax 7 Microcrystalline wax 6 Hydrogenated polyisobutene 12 Dipentaerythrity1 5 hexahydroxystearate/hexastearate/hexarosinate Isotridecyl isononanoate 10 Trimethylolpropane triisostearate 5 Bis-behenyl/isostearyl/phytosteryl dimer dilinoleyl dimer 3 dilinoleate Phytosteryl/octyldodecyl lauroy1 glutamate 2 Tocopherol 0.1 Antiseptic (chlorphenesin) 0.3 C Titanium oxide, mica, silica (compound powder) 0.5 Mica, titanium oxide (compound powder) 2 D Red 201 0.3 Red 202 0.6 The powder of Example 2-1 3.0 Polyglyceryl-2 triisostearate 3 E Polyglyceryl-2 triisostearate 21.4 Total (mass %) 100

Prescription Example 2

[0176] As cosmetics or skin topical agents using the powder compositions of the present invention, leave-on cosmetics were prepared by using components shown in Table 14 as follows.

[0177] After Component A and Component B were separately heated to 80° C. and dissolved, the Component A was added to the Component B while agitating. The mixture was emulsified by using a homo-mixer (3000 rpm, 3 minutes, 80° C.), followed by cooling to room temperature to obtain a leave-on cosmetic.

[0178] The leave-on cosmetic of Prescription Example 2 was excellent in moistness after the application, and had a good glossiness when applied. Furthermore, the leave-on cosmetic of Prescription Example 2 had good stability and antiseptic property.

TABLE-US-00025 TABLE 14 Leave-on cosmetic Names of raw materials Blending amount A UV absorber (ethylhexyl methoxycinnamate) 2 Squalane 6 Cetyl ethylhexanoate 3 Cetanol 2.8 Stearic acid 2.4 Propylene glycol stearate 1.2 Glyceryl stearate (SE) 3.3 Polysorbate 60 0.5 PEG-40 stearate 1.5 Tocopherol 0.05 The powder of Example 2-8 6 Phytosteryl macadamiate 1 Antiseptic (pentylene glycol) 1 B BG 5 Xanthan gum 0.1 Antiseptic (sodium dehydroacetate) 0.1 Water 64.05 Total (mass %) 100

Examples 12-1 to 12-7

[0179] Raw materials were weighed in a blending ratio (% by mass) shown in Table such that the total weight was 5.0 g, and all the raw materials were simultaneously introduced into Labo Milser (TESCOM Mill & Mixer TML162). An evaluation sample was obtained by mixing the raw materials for 100 seconds (five times each for seconds, the powder attached to the inner wall surface was scraped off between mixing processes).

TABLE-US-00026 TABLE 15 Example Example Example Example Example Example Example 12-1 12-2 12-3 12-4 12-5 12-6 12-7 Acyllysine of Preparation 8 8 8 8 8 10 10 Example 1 Plate-shaped crystalline 28 28 28 28 28 cellulose *1 Starch *2 80 Starch *3 80 Porous spherical silica *4 64 Porous spherical silica *5 64 Porous spherical silica *6 64 Porous spherical silica *7 64 Hollow spherical silica *8 64 Hollow spherical silica *9 10 Hollow spherical silica *10 10
Raw materials: Raw materials used in Examples shown in Table 15 described above are
as follows.
*1 produced by Nippon Paper Chemicals Co., Ltd.: average particle diameter 24 μm
*2 produced by DAITO KASEI KOGYO CO., LTD.: average particle diameter 10
*3 produced by NIPPON STARCH CHEMICAL CO., LTD.: average particle diameter
18 μm
*4 produced by Miyoshi Kasei Inc.: average particle diameter 5 μm
*5 produced by Sunjin Co., Ltd.: average particle diameter 7 μm
*6 produced by Kobo Products Inc.: average particle diameter 20 μm
*7 produced by Kobo Products Inc.: average particle diameter 5 μm
*8 produced by Miyoshi Kasei Inc.: average particle diameter 7 μm
*9 produced by JGC Catalysts and Chemicals Ltd.: average particle diameter 4 μm
*10 SUZUKIYUSHI INDUSTRIAL CORPORATION: average particle diameter 6 μm

Prescription Examples 3 to 9

[0180] Loose powders were prepared by using components shown in Table 16 as follows.

[0181] Component A was mixed, and finely pulverized by using a fine pulverizer. Component B was introduced into the component A, followed by agitating and mixing. A mixture of Component C was added, followed by agitating and mixing. Moreover, a mixture of Component D was added, followed by agitating and mixing to obtain a loose powder.

[0182] The loose powders of Prescription Examples 3 to 9 were excellent in slipperiness, adhesion, and uniformity when applied, and were also excellent in moistness and soft focus effect after application.

TABLE-US-00027 TABLE 16 Loose powder Prescription Prescription Prescription Prescription Prescription Prescription Prescription Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Blending Blending Blending Blending Blending Blending Blending Names of raw materials amount amount amount amount amount amount amount A Mica 38.8 38.8 38.8 38.8 38.8 38.8 38.8 Iron oxide (Yellow type) 1 1 1 1 1 1 1 Iron oxide (Red type) 0.7 0.7 0.7 0.7 0.7 0.7 0.7 Iron oxide (Black type) 0.25 0.25 0.25 0.25 0.25 0.25 0.25 Mica, bismuth oxychloride, 1 1 1 1 1 1 1 iron oxide (Yellow type) Mica, bismuth oxychloride, 0.5 0.5 0.5 0.5 0.5 0.5 0.5 iron oxide (Red type) Mica, bismuth oxychloride, 0.25 0.25 0.25 0.25 0.25 0.25 0.25 iron oxide (Black type) The powder of Example 12-1 30 The powder of Example 12-2 30 The powder of Example 12-3 30 The powder of Example 12-4 30 The powder of Example 12-5 30 The powder of Example 12-6 30 The powder of Example 12-7 30 Titanium oxide, aluminum 3 3 3 3 3 3 3 hydroxide, stearic acid Carnauba wax, calcium 2 2 2 2 2 2 2 silicate B Rice bran wax 15 15 15 15 15 15 15 C Dimethicone (50cs type) 2 2 2 2 2 2 2 Caprylyl glycol, 0.5 0.5 0.5 0.5 0.5 0.5 0.5 phenoxyethanol, hexylene glycol D Mica, iron oxide (Brown 5 5 5 5 5 5 5 type) Total (mass %) 100 100 100 100 100 100 100

Prescription Example 10

[0183] An eye makeup cosmetic was prepared by using components shown in Table 17 as follows.

[0184] A component was mixed for 10 minutes, and then B component was added to the A component, followed by further mixing for 20 minutes. C component was mixed for 10 minutes by using a mixer (FM 10C/I manufactured by Nippon Coke & Engineering Co., Ltd.), and then added to the mixture of A component+B component, followed by further mixing for 5 minutes. The mixture thus obtained was packed in a container, and was compressed by using a press machine to obtain a target eye makeup cosmetic.

[0185] The eye makeup cosmetic of Prescription Example 4 was excellent in pearlescence, gloss, shine, and color production after application.

TABLE-US-00028 TABLE 17 Eye-makeup cosmetic Blending Names of raw materials amount A Boron nitride 11.7 Talc 10 Myristic acid Mg 5 Silica 5 Iron oxide (Red) 1 Iron oxide (Yellow) 0.3 The powder of Example 2-1 2 B Caprylic/capric triglyceride 8 C Calcium sodium borosilicate 5 Synthetic fluorphlogopite, titanium oxide, iron oxide, 10 tin oxide Mica, titanium oxide, iron oxide 10 Mica, titanium oxide, iron oxide, silica, tin oxide 8 Synthetic Fluorphlogopite, titanium oxide, carmine 1 Mica, titanium oxide, iron oxide, chromium oxide 8 Calcium aluminum borosilicate, titanium oxide, silica, 5 tin oxide, dimethicone crosspolymer Mica, titanium oxide, iron oxide, ferric ferrocyanide 3 The powder obtained in Example 2-1 7 Total (mass %) 100