Immunotherapeutic method for treating lung cancer by administering a polypeptide comprising an epitope of hZP3
11819542 · 2023-11-21
Assignee
Inventors
Cpc classification
C07K14/705
CHEMISTRY; METALLURGY
A61K35/17
HUMAN NECESSITIES
A61K38/177
HUMAN NECESSITIES
A61K39/39
HUMAN NECESSITIES
A61K38/1774
HUMAN NECESSITIES
A61K39/001114
HUMAN NECESSITIES
A61K47/68
HUMAN NECESSITIES
A61K35/15
HUMAN NECESSITIES
A61K39/3955
HUMAN NECESSITIES
A61K2039/5154
HUMAN NECESSITIES
A61K51/00
HUMAN NECESSITIES
International classification
A61K39/00
HUMAN NECESSITIES
A61K35/15
HUMAN NECESSITIES
A61K39/39
HUMAN NECESSITIES
A61P35/00
HUMAN NECESSITIES
Abstract
The present invention relates to treatment and diagnosis of lung cancer and metastases thereof. More specifically, the invention relates to such therapeutic use of antigen sources providing immunogenic polypeptides comprising at least an immunogenic portion of a cancer cell associated protein, which preferably is a zona pellucida (ZP) protein, especially a ZP3 protein or the extracellular domain thereof, whereby the antigen source induces a cellular immune response against the lung cancer cells. The antigen source can be a proteinaceous composition comprising such immunogenic ZP polypeptide, a nucleic acid encoding the immunogenic ZP polypeptide, or a cell expressing or presenting the immunogenic ZP polypeptide. In addition, the invention relates to the therapeutic use of a T cell comprising a T cell receptor that binds an MHC-peptide complex, wherein the peptide is a peptide from the immunogenic ZP polypeptide. The invention further relates to the therapeutic and/or diagnostic use of antibodies that specifically binds to the immunogenic ZP polypeptide.
Claims
1. A method for the therapeutic and/or prophylactic treatment of lung cancer expressing human Zona Pellucida protein 3 (hZP3) and/or metastases thereof in a human, the method comprising administering an effective amount of a pharmaceutical composition to the human, wherein the pharmaceutical composition comprises a source of an immunogenic polypeptide comprising at least one of a class I and a class II major histocompatibility complex (MHC)-restricted epitope from the amino acid sequence of SEQ ID NO:3.
2. The method of claim 1, wherein the source of an immunogenic polypeptide is a composition comprising: a) one or more immunogenic peptides comprising or consisting of an amino acid sequence selected from SEQ ID NO.'s 66-72, 74 and 75; and/or, b) one or more immunogenic peptides comprising or consisting of an amino acid sequence selected from SEQ ID NO.'s 76-85.
3. The method of claim 1, wherein the method of treatment is a method of preventing metastases and/or recurrence of lung cancer, wherein optionally, the lung cancer is non-small cell lung cancer.
4. The method of claim 1, wherein the method of treatment is combined with an immunomodulating therapy, surgery, radiation therapy, chemotherapy, targeted therapy or a combination thereof.
5. The method of claim 4, wherein the immunomodulating therapy comprises the use of at least one of a checkpoint inhibitor, an antibody targeting a tumor necrosis factor (TNF) receptor family member, an immunosuppressive cytokine, a γC cytokine, a Toll-like receptor (TLR) agonist and an agonist of invariant natural killer T (iNKT) cells.
6. The method of claim 1, wherein the source of the immunogenic polypeptide comprises a proteinaceous composition comprising at least one source of an immunogenic polypeptide comprising at least one of a class I MHC- and a class II MHC-restricted epitope from the amino acid sequence of SEQ ID NO:3.
7. The method of claim 6, wherein the proteinaceous composition comprises at least one immunogenic polypeptide comprising a contiguous amino acid sequence of at least 18 amino acids selected from the amino acid sequence of SEQ ID NO:3 and wherein the contiguous amino acid sequence comprises at least one of a class I MHC- and a class II MHC-restricted T cell epitope.
8. The method of claim 7, wherein the proteinaceous composition comprises more than one different immunogenic polypeptide, each comprising a contiguous amino acid sequence of at least 18 amino acids selected from the amino acid sequence of SEQ ID NO:3 and having a length in the range of 18-100 amino acids, optionally a length in the range of 18-60 amino acids.
9. The method of claim 1, wherein the source of the immunogenic peptide collectively comprises at least one of: a) at least 50, 70, 80, 90 or 95% of the complete amino acid sequence of SEQ ID NO: 3; and, b) at least 50, 70, 80, 90 or 95% of the potential MHC I and/or MHC II epitopes predicted by a computer-based algorithm bio-informatics tool.
10. The method of claim 1, wherein the method further comprises administering, optionally co-administering, at least one adjuvant.
11. The method of claim 1, wherein the composition is administered by at least one of intratumoral, intramuscular, intraperitoneal, intradermal, subcutaneous, transdermal administration, and administration into an anatomic site that drains into at least one lymph node basin.
12. The method of claim 8, wherein the more than one different immunogenic polypeptide collectively comprises at least one of: a) at least 50, 70, 80, 90 or 95% of the complete amino acid sequence of SEQ ID NO:3; and, b) at least 50, 70, 80, 90 or 95% of the potential WIC I and/or WIC II epitopes predicted by a computer-based algorithm bio-informatics tool.
Description
DESCRIPTION OF THE FIGURES
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EXAMPLES
Example 1
(8) The expression of ZP3 in human lung cancer tissue is determined using immunohistochemistry (IHC). Tissue micro arrays (TMAs) from lung cancer tissues originating from different patients were obtained from a pathology institute in the Netherlands.
(9) Immunohistochemical determinations were done with human ZP3 monoclonal antibodies H3.1 in two different concentrations; 1.0 μg/mL and 0.1 μg/mL.
(10) Sections of human ovary containing oocytes were used as tissue positive controls. In addition, a sample of spleen tissue was used as a negative control.
(11) The following IHC protocol was used for all samples:
(12) Day 1
(13) 1. Deparaffinization and hydration: a) Xylen—3×3 min, b) Abs. EtOH—2×3 min, c) 96% EtOH—2×3 min, d) 70% EtOH—2×3 min e) dH.sub.2O—1×10 min, 2. Antigen retrieval: a) 10 mM citric acid buffer with 0.05% Tween 20 (pH 6.0) in retriever for 2.5 h b) cool down 3. Wash sections in Tris-Buffered Saline (TBS) with 0.05% Tween 20 (TBST) 3 times for 5 minutes each. 4. Incubate sections in 3% H.sub.2O.sub.2 (diluted in TBS) for 15 minutes to quench endogenous peroxidase activity at room temperature (RT), in dark. 5. Wash sections in TBST (TBS with 0.05% Tween 20) 2 times for 5 minutes each. 6. Incubate sections in 1 mg/mL sodium borohydride solution (diluted in TBS) for 15 minutes to quench free aldehyde groups (RT, in dark, more important for IF staining, ZP3 co-localization). 7. Wash sections in TPBS (TBS with 0.05% Tween 20) 3 times for 5 minutes each. 8. Incubate sections in blocking solution—3% BSA in TBST (1 h; RT; humidified chamber). 9. Incubate sections with primary antibody against hZP3 (1.0, 0.125 or 0.1 μg/ml) diluted in blocking solution (3% BSA in TBST) overnight in humidified chamber in the cold room.
Day 2 10. Wash sections in TBST 3 times for 5 minutes each. 11. Incubate sections with anti-mouse DAKO polymer 30 min (EnVision #4001). 12. Wash sections in TBST 3 times for 5 minutes each. 13. Incubate sections with Chromogen System (DAKO, 1 drop for 1 ml of buffer #K3468) —10 min, stop the reaction by dipping slides in container with tap water. 14. Incubate sections in tap water for 2 min. 15. Rinse slides with ddH.sub.2O before counterstaining 16. Counterstain sections in hematoxilin—20-30 s. 17. Incubate sections in tap water to remove excess of hematoxylin. 18. Dehydrate sections: a. 70% EtOH—2×3 min b. 96% EtOH—2×3 min c. Abs. EtOH—2×3 min d. Xylene—3×3 min 19. Mount with Pertex.
(14) In the positive controls, antibodies detect proteins in the ZP surrounding the human oocyte. ZP3 proteins are also present in the oocyte cytoplasm. No positive staining is detected in sections of the lung cancer tissue samples when the primary antibody is omitted. No positive staining is observed, with the ZP monoclonal antibody, in spleen and liver tissue.
(15) In the lung cancer samples (TMAs), presence of the ZP3 is confirmed by areas of the tissue staining positive for ZP3, with intensities varying among the samples obtained from different patients (see results of the squamous cell cancer TMAs in Table 1). Such tumors staining positive for ZP3 expression can be treated by immunization with ZP3-antigens in accordance with the present invention.
(16) TABLE-US-00001 TABLE 1 Non-small cell lung cancer (NSCLC)- Squamous cell cancer, n = 42 (TMAs) Result Percentage Result Percentage ZP3 ZP3 antibody concentration antibody concentration Scoring (1. 0 μg/mL) (0. 1 μg/mL) Negative 1 2% 4 33% No Score 4 10% 6 14% Positive 37 88% 22 52% Details of positive score Weak (>0-1) 2 5% 2 9% Intermediate (>1-2) 24 65% 16 73% Strong (>2-3) 11 30% 4 18%
Example 2
(17) The expression of ZP3 in human lung cancer tissue is determined using IHC (squamous cell cancer, n=10 and lung adenocarcinoma, n=10) and RNA scope in situ hybridization (squamous cell cancer, n=4 and lung adenocarcinoma, n=4). Tissue samples were from different patients were obtained from a pathology institute in Poland.
(18) Immunohistochemical determinations were done with human ZP3 monoclonal antibodies in two different concentrations. The same IHC protocol was followed as described in Example 1.
(19) Sections of human ovary was used as tissue positive control. In addition, a sample of spleen tissue was used as a negative control.
(20) In situ hybridization of formalin fixed paraffin embedded (FFPE) human ovary and cancer samples were done with RNAscope FFPE 2.0 HD Detection Kit Brown [Advanced Cell Diagnostics (ACD), Hayward, California, USA, CAT #310033] according to manufacturer's protocol.
(21) Deparaffinized FFPE Sections
(22) 1. In a fume hood, fill two clearing agent dishes with ˜200 ml fresh xylene and 2 with 200 mL fresh 100% ethanol. 2. Place the slides in the first xylene-containing clearing agent dish and incubate for 5 min at RT. Agitate the slides by occasionally lifting the slide rack up and down in the clearing agent dish. 3. Remove the slide rack from the first xylene-containing dish and immediately place in the second xylene-containing clearing agent dish in the fume hood and repeat incubation. 4. Remove the slide rack from the second xylene-containing dish and immediately place in the staining dish containing 100% ethanol. Incubate the slides in 100% ethanol for 1 min at RT with agitation. 5. Repeat step 4 with fresh 100% ethanol. 6. Remove the slides from the rack, and place on absorbent paper with the section face-up. Air Dry for 5 min at RT.
Equilibrate Equipment 1. Turn on HybEZ™ OVEN and set temperature to 40° C. 2. Place a humidifying paper in the humidity control tray and wet completely with Distilled water. 3. Insert covered tray into oven and close the oven door. Warm the tray for 30 min at 40° C. before use.
Prepare 1× Pretreat 2
(23) Prepare 700 mL of fresh 1× pretreat 2 by adding 630 mL distilled water to 1 bottle (70 mL) 10× pretreat 2 solution in a 1 L beaker. Mix well. Place the beaker containing 1× pretreat 2 on the hot plate. Cover the beaker with foil and turn the hot plate on high for 10-15 min. Once 1× pretreat 2 reaches boiling, turn the hot plate knob to 100-104° C. to maintain uniform boiling.
(24) Pretreat 1 & 2
(25) 1. Apply pretreat to cover the entire section and incubate for 10 min at RT. 2. Remove pretreat 1 solution from one slide at a time by tapping the slide on absorbent paper, and/or flicking. Immediately insert the slide into a slide rack submerged in a staining dish filled with distilled water. 3. Wash the slides twice in the distilled water. 4. Apply pretreat 2. Ensure that 1× pretreat 2 solution is at mild boiling. With a pair of forceps very slowly submerge the slide rack containing the slides into the boiling 1× pretreat 2 solution. Cover the beaker with foil and boil the slides for 15 min. After pretreatment time is over, use the forceps to immediately transfer the hot slide rack from the 1× pretreat 2 to the staining dish containing distilled water. Do not let the slides cool in Pretreat 2. 5. Wash the slides twice in the distilled water. 6. Wash the slides in fresh 100% ethanol by moving the rack up and down 3-5 times. Air dry the slides. Create a hydrophobic barrier using hydrophobic barrier pen. 7. Place the dried slides on the slide rack, and add pretreat 3 to entirely cover each section. Remove the HybEZ™ humidity control tray from the HybEZ™ oven and place the HybEZ™ slide rack in the tray. Close the lid, and insert tray back into the oven. 8. Incubate the slides at 40° C. for 30 min. 9. Remove the HybEZ™ humidity control tray from the oven. 10. Wash the slides twice with distilled water. 11. Add appropriate probe to entirely cover each section. Human ZP3 probe (Cat No. 442631), positive control probes for low abundance transcripts Mm-Polr-2a, #312471) and negative control probe (DapB, ACD-310043) Place the HybEZ™ slide rack in the HybEZ™ humidity control tray, cover with lid and insert into the oven for 2 hr at 40° C. 12. Remove the HybEZ™ control tray from the oven and remove HybEZ™ slide rack. 13. Wash the slides in 1× wash buffer for 2 min at RT. Agitate slides by moving the slide rack up and down in the dish. 14. Repeat Step 13 with fresh 1× wash buffer. 15. Incubate the slides with Amp 1 entirely cover each section for 30 min at 40° C. 16. Wash the slides twice in 1× wash buffer for 2 min at RT with occasional agitation. 17. Incubate the slides with Amp 2 entirely cover each section for 15 min at 40° C. 18. Wash the slides twice in 1× wash buffer for 2 min at RT with occasional agitation. 19. Incubate the slides with Amp 3 entirely cover each section for 30 min at 40° C. 20. Wash the slides twice in 1× wash buffer for 2 min at RT with occasional agitation. 21. Incubate the slides with Amp 4 entirely cover each section for 15 min at 40° C. 22. Wash the slides twice in 1× wash buffer for 2 min at RT with occasional agitation. 23. Incubate the slides with Amp 5 entirely cover each section for 30 min at RT. 24. Wash the slides twice in 1× wash buffer for 2 min at RT with occasional agitation. 25. Incubate the slides with Amp 6 entirely cover each section for 15 min at RT. 26. Wash the slides twice in 1× wash buffer for 2 min at RT with occasional agitation. 27. Mix equal volumes of brown-A and brown-B (DAB substrate) in an appropriately sized tube by dispensing the same number of drops (2 drops of each reagent total of 4) for each solution. Pipette DAB onto each tissue section. Ensure sections are covered, and incubate for 10 min at RT. 28. Wash the slides in distilled water by moving the slide rack up and down 3-5 times. Replace with fresh distilled water. 29. Counterstain the slides in 50% hematoxylin staining solution for 2 min at RT. 30. Wash the slides in distilled water by moving the slide rack up and down 3-5 times. Keep repeating with fresh distilled water until the slides are clear, while sections remain purple. 31. Replace distilled water in the staining dish with 0.02% ammonia water. Move rack up and down 2-3 times. Section should turn blue. Replace ammonia water with distilled water. Wash the slides 3-5 times. 32. Dehydrate the slides (70% ethanol for 2 min, 100% 70% ethanol for 2 min, xylene for 5 min). 33. Mount the samples with Pertex.
(26) In the positive controls, antibodies detect proteins in the ZP surrounding the human oocyte, as well as in the oocyte cytoplasm (
(27) In the lung cancer samples, the subtypes squamous cell cancer (
Example 3
(28) The sequence of hZP3 was analysed for HLA class I restricted cytotoxic T cell (CTL) epitopes and HLA class II restricted T helper epitopes using algorithms that predict HLA class I and II peptide binding.
(29) The MHC class I binding predictions was performed using the NetCTLpan Server from the Center for Biological Sequence Analysis (CBS), Technical University of Denmark (www.cbs.dtu.dk/) (Xu et al., 2012, Clin Dev Immunol; 12:831010).
(30) The MHC class II binding predictions were made using the IEDB analysis resource Consensus tool (tools.immuneepitope.org/) (Stranzl et al., 2010, Immunogenetics; 62:357-368; Wang et al., 2008, PLoS Comput Biol. 4(4):e1000048). This tool employs different methods to predict MHC Class II epitopes, including a consensus approach which combines NN-align, SMM-align and combinatorial library methods. A low percentile rank is equal to good binders.
(31) The alelles submitted were those belonging to the HLA class I and II supertypes (Wang et al., 2010, BMC Bioinformatics. 11:568; Sidney et al., 2008, BMC Immunol.; 9:1. doi:10.1186/1471-2172-9-1). MHC molecules are extremely polymorphic but, despite this polymorphism HLA class I molecules can be clustered into groups, designated as supertypes, representing sets of molecules that share largely overlapping peptide binding specificity (Wang et al., 2010 BMC Bioinformatics. 11:568). In the same way, seven different supertypes (main DR, DR4, DRB3, main DQ, DQ7, main DP, and DP2) were defined for HLA class II (Greenbaum et al., 2011, Immunogenetics; 63(6):325-35).
(32) The hZP3 peptide sequence was submitted without the signal peptide and transmembrane domain, i.e from aa 23 to aa 387. Results of the analysis are contained in Table 2 and 5 (MHC class I ligands) and in Table 3 (MHC class II ligands).
(33) The MHC class I and class II ligands presented in Table 2 and 3 resp., serve as a guideline for designing immunogenic peptides of the invention, for example a composition comprising one or more polypeptides, wherein said one or more polypeptides comprise one or more MHC class I restricted epitopes selected from Table 2 and/or one or more MCH class II restricted epitopes selected from Table 3.
(34) A series of hZP3 peptides covering the hZP3 sequences for use in a clinical setting are contained in
(35) TABLE-US-00002 TABLE 2 Predicted MHC class I ligands contained in the hZP3 protein. SEQ ID aa* Ligand sequence HLA allele (%Rank) NO: 34- HPETSVQPV HLA-B*07:02 (0.80) 6 42 35- PETSVQPVL HLA-B*40:01 (0.80) 7 43 47- ***QEATLMVMV HLA-B*40:01 (0.80) 8 55 49- ATLMVMVSK HLA-A*03:01 (0.30) 9 57 65- LIRAADLTL HLA-B*07:02 (0.80) 10 73 86- TEDVVRFEV HLA-B*40:01 (0.40) 11 94 104- QVTDDALVY HLA-A*01:01 (0.30); HLA- 12 112 A*26:01 (0.40) 109- ALVYSTFLL HLA-A*02:01 (0.80) 13 117 115- FLLHDPRPV HLA-A*02:01 (0.80) 14 123 121- RPVGNLSIV.sup.¶ HLA-B*07:02 (0.30) 15 129 142- YPRQGNVSS.sup.¶ HLA-B*07:02 (0.80) 16 150 149- SSQAILPTW HLA-B*58:01 (0.10) 17 157 152- AILPTWLPF HLA-B*15:01 (0.80) 18 160 157- WLPFRTTVF HLA-A*24:02 (0.80); HLA- 19 165 3*08:01; HLA-3*15:01 (0.80) 164- VFSEEKLTF HLA-A*24:02 (0.30) 20 172 166- SEEKLTFSL HLA-3*40:01 (0.15) 21 174 175- RLMEENWNA HLA-A*02:01 (0.20) 22 183 190- FHLGDAAHL HLA-3*39:01 (0.05) 23 198 202- ***IHTGSHVPL HLA-3*39:01 (0.10) 24 210 228- SPYHTIVDF HLA-3*07:02 (0.80) 25 234 243- GLTDASSAF HLA-3*15:01 (0.20) 26 251 244- LTDASSAFK HLA-A*03:01 (0.80) 27 252 253- VPRPGPDTL HLA-3*07:02 (0.15) 28 261 255- RPGPDTLQF HLA-3*07:02 (0.30) 29 263 262- QFTVDVFHF HLA-A*24:02 (0.80) 30 270 263- FTVDVFHFA HLA-A*02:01 (0.80); HLA- 31 271 A*26:01 (0.80) 271- ANDSRNMIY.sup.¶ HLA-A*01:01 (0.30) 32 279 277- MIYITCHLK HLA-A*03:01 (0.10) 33 285 278- IYITCHLKV HLA-A*24:02 (0.20) 34 286 302- FSKPSNSWF HLA-3*15:01 (0.80) 35 310 304- KPSNSWFPV HLA-3*07:02 (0.30) 36 312 334- RQPHVMSQW HLA-A*24:02 (0.80) 37 342 371- RGDHEVEQW HLA-3*58:01 (0.80) 38 379 *Position is that of aa in complete hZP3 protein. .sup.¶Ligand contains N-linked glycosylation site (position 125, 147 and 272, respectively).
(36) TABLE-US-00003 TABLE 3 Predicted MHC class II ligands contained in the hZP3 protein. SEQ ID aa* Core sequence HLA allele (percentile rank).sup.§ NO: 48- EATLMVMVS DQA1*01:02/DQB*06:02 (0.14) 39 56 51- LMVMVSKDL DRB5*01:01 (0.88); DRB1*15:01 (2.37) 40 59 52- MVMVSKDLF DRB1*03:01 (1.01) 41 60 65- ****LIRAADLTL DRB1*08:02 (2.49) 42 73 81- LVMSDTEDV DRB1*01:02 (1.31) 43 89 82- VSMDTEDVV DRB1*03:01 (0.54) 44 90 89- VVRFEVGLH DRB1*11:02 (0.52) 45 97 104- QVTDDALVY DRB1*03:01 (1.91) 46 112 109- ALVYSTFLL DPA1*01:03/DPB1*02:01 (0.01); 47 117 DPA1*02:01/DPB1*01:01 (0.12) 110- LVYSTFLLH DPA1*01/DPB1*04:01 (0.01); 48 118 DPA1*0301/DPB1*04:02 (0.04) 115- FLLDPHRPV DRB1*11:02 (0.39) 49 123 116- LLHDPRPVG DRB1*03:01 (0.17) 50 124 126- *LSIVRTNRA.sup.‡ DRB1*08:02 (1.55) 51 134 128- IVRTNRAEI DRB1*03:01 (1.77) 52 136 159- PFRTTVFSE DPA1*01:03/DPB1*02:01 (0.58); HLA- 53 167 DPA1*02:01/DPB1*01:01 (0.69) 160- FRTTVFSEE DPA1*01/DPB1*04:01 (0.35) 54 168 171- **TFSLRLMEE DQA1*04:01/DQB1*04:02 (1.05) 55 179 190- FHLGDAAHL DRB1*09:01 (0.49) 56 198 210- LRLFVDHCV DQA1*01:01 (0.48) 57 218 212- LFVDHCVAT DRB1*03:01 (2.05) 58 220 262- QFTVDVFHF DRB3*01:01 (1.5) 59 270 270- FANDSNRMI.sup.¶ DRB3*01:01 (0.35); DRB3*02:02 (1.37); 60 278 DRB1*03:01 (1.77) 278- IYITCHLKV DRB1*11:01 (1.16); 61 286 DPA1*03:01/DPB1*04:02 (1.53) 339- VMSQWSRSA DRB1*11:02 (0.79) 62 347 343- WSRSASRNR DRB5*01:01 (1.4) 63 351 365- LIFLDRRGD DRB1*11:02 (1.01) 64 373 366- IFLDRRGDH DRB1*03:01 (0.08) 65 374 *Position is that of aa in complete hZP3 protein. .sup.§The percentile rank is given in parentheses after the corresponding HLA allele; only ligands with percentile ranks > 2.5 were considered. .sup.‡N-linked glycosylation site in preceding position 125. .sup.¶Ligand contains N-linked glycosylation site (position 272).
Example 4
(37) With in silico prediction software, potential HLA-A2 restricted T cell epitopes from rhZP3 protein has been identified. The software used was NETMHCPAN 3.0 in silico prediction software.
(38) TABLE-US-00004 TABLE 5 HLA-A2 restricted T cell epitopes from rhZP3 protein. SEQ Affinity ID Number Position Peptide (nM) %Rank NO 1 115 FLLHDPRPV 5.1 0.04 76 2 175 RLMEENWNA 5.2 0.04 77 3 109 ALVYSTFLL 21.3 0.3 78 4 263 FTVDVFHFA 19.9 0.3 79 5 174 LRLMEENWNA 28.6 0.4 80 6 367 FLDRRGDHEV 53.2 0.7 81 7 239 CLVDGLTDA 79.1 0.9 82 8 276 NMIYITCHL 76.6 0.9 83 9 114 TFLLHDPRPV 101.9 1.1 84 10 64 KLIRAADLTL 129.9 1.2 85
(39) An in vivo pre-clinical efficacy study has been conducted to assess the immune response and the anti-tumor response after immunization with rhZP3 polypeptide (aa 1-383 with his-tag) and 5 different ZP3 epitopes. The hZP3 epitopes were selected based on CD8.sup.+ T cell responses observed during previously performed immunogenicity experiments with rhZP3 polypeptide (aa 1-383) and with pools of peptides comprising hZP3 epitopes as indicated (see Table 5) combined with different adjuvants (data not shown). The peptides were synthesized by Pepscan (the Netherlands) at a purity >96%.
(40) In this experiment in a therapeutic setting, HLA-A2 transgenic mice with a ZP3-expressing tumor were treated with the rhZP3 protein, pool of hZP3 peptides or PBS as control.
(41) A HLA-A2 transgenic mice model was used for this study. To set up the tumor model, B16-HLA-A2 transgenic murine melanoma cell line was transfected with rhZP3 (see example in Tran et al., Clin Cancer Res, 2016; 22(16):4133-44).
(42) Three groups of female HLA-A2 transgenic mice (n=6) with ZP3 expressing tumors were treated with: 1. PBS; 2. Pool of 5 hZP3 peptides (5 dominant peptides previously identified in HLA-A2/DR1 mice, including the epitopes identified as 4, 5, 6, 8 and 9 in Table 5; 0.5 nmol per peptide) plus GM-CSF/CpG as adjuvant (20 μg GM-CSF and 50 μg CpG); and, 3. rhZP3 protein (100 μg, s.c.) plus GM-CSF/CpG as adjuvant (20 μg GM-CSF and 50 μg CpG).
(43) On Day 0 (DO), a tumor injection with 10.sup.6 cells/mouse (s.c.) was given. Thereafter, the prime injection was administered 7 to 10 days (D7-10) and a boost injection on Day 14 to Day 17 (D14-17). Tumor size was monitored after treatment. At Day 30 to 35, mice were sacrificed to determine ZP3 specific TCD8+ response (ELISpot). See schedule in
(44) After administration of PBS, tumor size did increase whereas after 2 s.c. immunizations with either rhZP3 protein or the combination of the 5 hZP3 peptides no growth of the tumor was observed (see
(45) Furthermore, as shown in
(46) TABLE-US-00005 TABLE 4 Combinations of amino acid sequences from FIG. 4, to be incorporated in immunogenic peptides for composing an composition of synthetic long peptides in accordance with the invention. The various combination are separated by semicolons. Combination of 2 peptides SEQ ID NO. 66, SEQ ID NO. 67; SEQ ID NO. 66, SEQ ID NO. 68; SEQ ID NO. 66, SEQ ID NO. 69; SEQ ID NO. 66, SEQ ID NO. 70; SEQ ID NO. 66, SEQ ID NO. 71; SEQ ID NO. 66, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68; SEQ ID NO. 67, SEQ ID NO. 69; SEQ ID NO. 67, SEQ ID NO. 70; SEQ ID NO. 67, SEQ ID NO. 71; SEQ ID NO. 67, SEQ ID NO. 72; SEQ ID NO. 67, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69; SEQ ID NO. 68, SEQ ID NO. 70; SEQ ID NO. 68, SEQ ID NO. 71; SEQ ID NO. 68, SEQ ID NO. 72; SEQ ID NO. 68, SEQ ID NO. 73; SEQ ID NO. 68, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70; SEQ ID NO. 69, SEQ ID NO. 71; SEQ ID NO. 69, SEQ ID NO. 72; SEQ ID NO. 69, SEQ ID NO. 73; SEQ ID NO. 69, SEQ ID NO. 74; SEQ ID NO. 69, SEQ ID NO. 75; SEQ ID NO. 70, SEQ ID NO. 71; SEQ ID NO. 70, SEQ ID NO. 72; SEQ ID NO. 70, SEQ ID NO. 73; SEQ ID NO. 70, SEQ ID NO. 74; SEQ ID NO. 70, SEQ ID NO. 75; SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 74, SEQ ID NO. 75; Combination of 3 peptides SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 71; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 71; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 71; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 71; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 72; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 72; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 72; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 73; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 73; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 74; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 70, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; Combination of 4 peptides SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; Combination of 5 peptides SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; Combination of 6 peptides SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; Combination of 7 peptides SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; Combination of 8 peptides SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; Combination of 9 peptides SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 67, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 66, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75; SEQ ID NO. 67, SEQ ID NO. 68, SEQ ID NO. 69, SEQ ID NO. 70, SEQ ID NO. 71, SEQ ID NO. 72, SEQ ID NO. 73, SEQ ID NO. 74, SEQ ID NO. 75;
(47) TABLE-US-00006 TABLE 6 Combinations of amino acid sequences from Table 5, to be incorporated in immunogenic peptides for composing an composition of synthetic long peptides in accordance with the invention. The various combination are separated by semicolons. Combination of 2 peptides SEQ ID NO. 76, SEQ ID NO. 77; SEQ ID NO. 76, SEQ ID NO. 78; SEQ ID NO. 76, SEQ ID NO. 79; SEQ ID NO. 76, SEQ ID NO. 80; SEQ ID NO. 76, SEQ ID NO. 81; SEQ ID NO. 76, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78; SEQ ID NO. 77, SEQ ID NO. 79; SEQ ID NO. 77, SEQ ID NO. 80; SEQ ID NO. 77, SEQ ID NO. 81; SEQ ID NO. 77, SEQ ID NO. 82; SEQ ID NO. 77, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79; SEQ ID NO. 78, SEQ ID NO. 80; SEQ ID NO. 78, SEQ ID NO. 81; SEQ ID NO. 78, SEQ ID NO. 82; SEQ ID NO. 78, SEQ ID NO. 83; SEQ ID NO. 78, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80; SEQ ID NO. 79, SEQ ID NO. 81; SEQ ID NO. 79, SEQ ID NO. 82; SEQ ID NO. 79, SEQ ID NO. 83; SEQ ID NO. 79, SEQ ID NO. 84; SEQ ID NO. 79, SEQ ID NO. 85; SEQ ID NO. 80, SEQ ID NO. 81; SEQ ID NO. 80, SEQ ID NO. 82; SEQ ID NO. 80, SEQ ID NO. 83; SEQ ID NO. 80, SEQ ID NO. 84; SEQ ID NO. 80, SEQ ID NO. 85; SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 84, SEQ ID NO. 85; Combination of 3 peptides SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 80; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 81; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 81; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 81; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 81; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 82; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 82; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 82; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 83; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 83; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 84; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 80, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; Combination of 4 peptides SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; Combination of 5 peptides SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; Combination of 6 peptides SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 84, SEQ ID NO. 85; 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SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; Combination of 7 peptides SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; Combination of 8 peptides SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; Combination of 9 peptides SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 77, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 76, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85; SEQ ID NO. 77, SEQ ID NO. 78, SEQ ID NO. 79, SEQ ID NO. 80, SEQ ID NO. 81, SEQ ID NO. 82, SEQ ID NO. 83, SEQ ID NO. 84, SEQ ID NO. 85;