Gel composition

Abstract

Provided are gelling agent compositions capable of preparing gel compositions with good stability, which include a composition containing (A) at least one kind of N-acyl acidic amino acid dialkylamide represented by the formula (I): ##STR00001##
wherein each symbol is as described in the DESCRIPTION) and (B) fatty acid having 3-22 carbon atoms or fatty acid having 3-22 carbon atoms and higher alcohol having 8-22 carbon atoms or (E) N-acylamino acid, a composition containing (A) at least one kind of N-acyl acidic amino acid dialkylamide represented by the formula (I) and (B′) a solvent having a boiling point of not more than 120° C. and not more than 2 wt % of water, and a composition containing a particular N-acyl acidic amino acid dialkylamide at a particular ratio.

Claims

1. A gel composition, comprising: (A″) 0.5 to 2 wt % of a mixture of dibutyl N-lauroyl glutamide (A″-1) and dibutyl N-2-ethylhexanoyl glutamide (A″-2) in a weight ratio (A″-1):(A″-2) of 1:4 to 1:20; formula (1); (B″) 0.5 to 20 wt % of at least one solvent selected from the group consisting of ethanol, 2-octyldodecanol, oleyl alcohol, pentyleneglycol, and myristic acid; (C″) 30 to 95 wt % of at least one oil agent selected from the group consisting of petrolatum, solid paraffin, liquid paraffin, cyclopentasiloxane, cetyl ethylhexanoate, ethylhexyl palmitate, isopropyl myristate, isopropyl palmitate, tri(caprylic acid/capric acid)glyceryl, triethylhexanoin, shea butter, almond oil, wheat germ oil, jojoba seed oil, olive oil, meadowfoam oil, N-lauroyl-L-glutamic acid di(phytosteryl/2-octyldodecyl), and isopropyl lauroylsarcosine; and optionally, (D″) 3 to 20 wt % of at least one emulsifier selected from the group consisting of polyglyceryl-10 dioleate, polyglyceryl-10 cocoate, polyglyceryl-3 cocoate, PEG-40 glyceryl triisostearate, and PEG-$0 &rend isostearate, wherein the breaking strength of the gel composition is not more than 200 g/cm.sup.2, and wherein all wt % are relative to the total weight of the gel composition.

2. The gel composition according to claim 1, wherein (C′) said at least ne oil agent is at least one oil agent for cosmetics or oil a, ent for pharmaceutical product selected from the group consisting of jojoba seed oil, wheat germ oil, isopropyl myristate, cetyl ethylhexanoate and tri(caprylic acid/capric acid)glyceryl.

3. The gel composition according to claim 1, further comprising (D″) the at least one emulsifier.

4. The gel composition according to claim 1, wherein the breaking strength of the gel composition is 15 to 150 g/cm.sup.2.

5. The gel composition according to claim 1, which is contained in a cosmetic, a perfumery or a quasi-drug composition.

6. The gel composition according to claim 1, wherein the dissolution temperature (melting point) of the gel composition is not more than 110° C.

7. The gel composition according to claim 1, which is free from dipropylene glycol.

8. The gel composition according to claim 1, wherein the breaking strength of the gel composition is 15 to 70 g/cm.sup.2.

Description

EXAMPLES

(1) While the present invention is explained in further detail by illustrating Examples, the present invention is not limited to the following Examples.

(2) Evaluation of Redissolution Temperature

(3) An appropriate amount of component (B) was measured into a glass vial, and an appropriate amount of component (A) was added to component (B). The mixture was heated and stirred in an oil bath to uniformly dissolve component (A) in component (B). The uniformly dissolved solution was cooled by placing at room temperature for not less than 3 hr. The mixture in solid or gel was heated and stirred in an oil bath, and the temperature at which a uniform solution was obtained again was measured by a thermometer and evaluated as a redissolution temperature.

(4) As component (A), an amino acid-based gelling agent “GP-1” manufactured by Ajinomoto Co., Inc. was used as dibutyl N-lauroyl-L-glutamide, an amino acid-based gelling agent “EB-21” manufactured by Ajinomoto Co., Inc. was used as dibutyl N-2-ethylhexanoyl glutamide (hereinafter the same), and prepared at GP-1:EB-21=3:2 (Experimental Example 1).

(5) In Experimental Example 2, they were used at a ratio of GP-1:EB-21=1:3-1:4.

(6) In Experimental Example 1 and Experimental Example 2, a redissolution temperature of 60° C. or lower was evaluated as “A” (very preferable), a redissolution temperature exceeding 60° C. and not higher than 70° C. was evaluated as “B” (preferable) and a redissolution temperature exceeding 70° C. was evaluated as “C” (unpreferable).

(7) Compatibility with Oil

(8) Each (2 g) of the various oil agents shown in Table 1 was measured in a separate, transparent glass vial, component (B) as a solvent (1 g) was added to each oil agent, and they were mixed in an oil bath at 60° C. for 1 hr. After standing for one day, the appearance was determined by visual observation.

(9) As the diagnostic criteria of the compatibility of 6 categories of the oil agents in the following Table and solvent, separation from at least three categories of oil agents was evaluated as “D” (not preferable), separation from at least two categories of oil agents was evaluated as “C” (not very preferable), separation from one category of oil agent was evaluated as “B” (preferable), and uniform dissolution of all categories of oil agents was evaluated as “A” (very preferable).

(10) TABLE-US-00001 TABLE 1 category of oil agent (classification) display name of oil agent non-polar oil agent liquid paraffin silicone oil agent cyclopentasiloxane ester oil agent isopropyl myristate oil agent for cleansing oil cetyl ethylhexanoate triglyceride oil agent almond oil tri(caprylic acid/capric acid)glyceryl amino acid-based oil agent lauroyl glutamic acid di(phytosteryl/octyldodecyl)

Experimental Example 1

(11) Mixtures (20 g) of (A) and (B) at proportions (wt %) shown in Tables 2-1, 2-2 and 2-3 were placed in glass vials, and the dissolution temperature and redissolution temperature were measured and evaluated as described above. The compatibility with the oil agent of (B) was evaluated as described above. The results are shown in Tables 2-1 to 2-3.

(12) As component (A), an amino acid-based gelling agent “GP-1” manufactured by Ajinomoto Co., Inc. was used as dibutyl N-lauroyl-L-glutamide, an amino acid-based gelling agent “EB-21” manufactured by Ajinomoto Co., Inc. was used as dibutyl N-2-ethylhexanoyl glutamide (hereinafter the same), and prepared at GP-1:EB-21=3:2.

(13) TABLE-US-00002 TABLE 2-1 Example Example Example Example Example Example Example component 1-1 1-2 1-3 1-4 1-5 1-6 1-7 A dibutyl lauroyl glutamide 12 12 12 12 12 12 12 (GP-1) A dibutyl ethylhexanoyl 8 8 8 8 8 8 8 glutamide (EB-21) B isostearic acid 80 — — — — — — B 2-hexyldecanoic acid — 80 — — — — B 2-ethylhexanoic acid — — 80 — — — — B isononanoic acid — — — 80 — — B myristic acid — — — — 80 — — B lauric acid — — — — — 80 — B capric acid — — — — — — 80 total (wt %) 100 100 100 100 100 100 100 dissolution temperature (° C.) 90 90 65 70 85 75 70 redissolution temperature 65 63 25 50 60 50 45 (° C.) qualitative evaluation of B B A A A A A redissolution temperature compatibility of various oil A A A A A A A agents and solvents

(14) TABLE-US-00003 TABLE 2-2 Ex. 1- Ex. 1- Ex. 1- Ex. 1- Ex. 1- Ex. 1- Ex. 1- Ex. 1- Ex. 1- Ex. 1- component 8 9 10 11 12 13 14 15 16 17 A dibutyl lauroyl 12 9 9 9 6 6 6 10.2 18 24 glutamide (GP-1) A dibutyl 8 6 6 6 4 4 4 6.8 12 16 ethylhexanoyl glutamide (EB-21) B 2-octyldodecanol — — — — 75 — — — — — B 2-hexyldecyl alcohol — 35 — — — — — — — — B isostearyl alcohol — — 35 — — 85 80 — — — B isostearic acid — 50 50 85 — — 10 83 — — B myristic acid — — — — 15 5 — — — — B capric acid — — — — — — — — 70 — B hexanoic acid 80 — — — — — — — — — B lactic acid — — — — — — — — — 60 total (wt %) 100 100 100 100 100 100 100 100 100 100 dissolution 65 90 90 85 85 80 80 90 90 85 temperature (° C.) redissolution 45 65 65 60 60 60 60 65 65 65 temperature (° C.) qualitative A B B A A A A B B B evaluation of redissolution temperature compatibility of A A A A A A A A A C various oil agents and solvents

(15) TABLE-US-00004 TABLE 2-3 Comp. Comp. Comp. Comp. Comp. Comp. Comp. Comp. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. 1-1 1-2 1-3 1-4 1-5 1-6 1-7 1-8 dibutyl lauroyl glutamide (GP-1) 12 12 12 12 12 9 18 24 dibutyl ethylhexanoyl glutamide (EB-21) 8 8 8 8 8 6 12 16 2-octyldodecanol 80 — — — — 85 70 — oleyl alcohol — 80 — — — — — — pentyleneglycol — — — — 80 — — — 2-hexyldecyl alcohol — — 80 — — — — — isostearyl alcohol — — — 80 — — — 60 total (wt %) 100 100 100 100 100 100 100 100 dissolution temperature (° C.) 125 110 110 110 80 110 150 140 redissolution temperature (° C.) 95 85 85 85 65 90 125 120 qualitative evaluation of redissolution temperature D D D D B D D D compatibility of various oil agents and solvents A A A A D A A A

(16) As shown in Tables 2-1, 2-2 and 2-3, when fatty acid or fatty acid and higher alcohol were used as the solvent, (A) could be dissolved at not more than 90° C. and it was confirmed that the redissolution temperature was as low as 70° C. or below. On the other hand, the dissolution temperature with higher alcohol alone was as high as 100° C. or above, and the redissolution temperature was also higher than 80° C. When pentylene glycol was mixed with various oil agents, it was separated over time and compatibility with the oil agents was not preferable. Thus, it was found that even though the dissolution temperature of the gelling agent could be lowered by utilizing polyol, since polyol has poor compatibility with non-polar oil agents, it causes phase separation from oil when added to the oil (Comparative Example 1-5).

Experimental Example 2

(17) Mixtures (20 g) of (A) and (B) at proportions (wt %) shown in Table 3 were placed in glass vials, and the dissolution temperature and redissolution temperature were measured and evaluated as described above. In addition, the compatibility with the oil agent of (B) was evaluated as described above. The results are shown in Table 3.

(18) TABLE-US-00005 TABLE 3 Comparative Comparative Example Example Example component Example 2-1 Example 2-2 2-1 2-2 2-3 A dibutyl lauroyl glutamide (GP-1) 5 5 5 3 6 A dibutyl ethylhexanoyl glutamide (EB-21) 15 15 15 9 24 B lactic acid — — — — 70 B capric acid — — 80 — — B myristic acid — — — 88 — B 2-octyldodecanol 80 — — — — B isostearyl alcohol — 80 — — — total (wt %) 100 100 100 100 100 dissolution temperature (° C.) 135 120 75 80 80 redissolution temperature (° C.) 115 100 70 70 70 qualitative evaluation of redissolution D D B B B temperature compatibility of various oil agents and A A A A C solvents

(19) As shown in Table 3, when fatty acid was used as the solvent, high doses of (A) could be dissolved at not more than 90° C. and it was confirmed that the redissolution temperature was as low as 70° C. or below. On the other hand, the dissolution temperature with higher alcohol alone was as high as 120° C. or above, and the redissolution temperature was also higher than 100° C. or above.

Experimental Example 3

(20) According to the proportions (wt %) shown in Table 4, component (B) was measured into a glass vial such that the total amount of a mixture of (A)-(D) was 20 g. Component (A) was added to component (B), and the mixture was heated and stirred in an oil bath to uniformly dissolve component (A) in component (B). The uniformly dissolved solution was cooled by placing at room temperature for not less than 3 hr. The uniform mixture of (A) and (B) that became solid or gel by cooling was heated and stirred in an oil bath at the redissolution temperature to give a uniform solution again. Component (C) or a mixture of component (C) and component (D) was measured into a separate glass vial and the mixture was uniformly mixed and dissolved. Finally, a mixed solution of (B) and (A) was added to component (C) or a mixed solution of component (C) and component (D) and the mixture was mixed by stirring at 80° C. The thus-obtained various compositions composed of a mixture of (A)-(D) were evaluated according to the following criteria. When mixing was not attainable even by stirring at 80° C., the mixture of (A)-(D) was uniformly mixed by heating at a higher temperature.

(21) Confirmation of Transparency

(22) The uniform solution obtained by heating and stirring was cooled for not less than 3 hr at room temperature (25° C.). The transparency of the mixture in the glass vial was confirmed (25° C.) by visual observation. A transparent solution was evaluated as “A” (preferable) and a cloud gel was evaluated as “B” (unpreferable).

(23) Evaluation of Sweating of Composition

(24) The uniform solution obtained by heating and stirring was cooled for not less than 3 hr at room temperature. The obtained solid or gel mixture was stored in an apparatus, in which the temperature can be continuously changed in a cycle of from −5° C. to 40° C., for the time period of 3 cycles. Thereafter, the gel mixture was taken out from the apparatus and stored in an environment of ordinary temperature and ordinary humidity for 12 hr. The surface of the gel mixture was visually observed (25° C.). A droplet confirmed on the surface was evaluated as “B” (unpreferable) due to sweating, and the absence of confirmation was evaluated as “A” (preferable) without sweating.

(25) Uniform Mixing Temperature of Mixture of (A)-(D) being not More than 80° C.

(26) A mixture of (A)-(D) which was prepared by the method of the above-mentioned Experimental Example 3 and could be uniformly mixed at 80° C. was evaluated as “A” (preferable), and a mixture of (A)-(D) which could not be uniformly mixed at 80° C. and was confirmed to contain granules and solid in the solution was evaluated as “B” (unpreferable).

(27) The results are shown in Tables 4-1 and 4-2.

(28) TABLE-US-00006 TABLE 4-1 compo- Example Example Example Example Example Example Example Example Example Example Example nent component 3-1 3-2 3-3 3-4 3-5 3-6 3-7 3-8 3-9 3-10 3-11 C liquid paraffin 25 25 25 25 90 — — 25 25 25 25 C cetyl 40 — 40 — — 90 — 40 — 40 — ethylhexanoate C wheat germ oil — 40 — 40 90 — 40 — 40 D PEG-15 25 25 — — — — — 25 25 — — hydrogenated castor oil isostearate (HLB 6) D polyglyceryl-10 — — 25 25 — — — — — 25 25 dioleate (HLB 11) A + B formulation of 10 10 10 10 10 10 10 — — — — Examples 1-1 to 1-8 A + B formulation of — — — — — — — 10 10 10 10 Examples 2-1 to 2-2 total (wt %) 100 100 100 100 100 100 100 100 100 100 100 confirmation of A A A A A A A A A A A transparency evaluation of A A A A A A A A A A A sweating of formulation uniform mixing A A A A A A A A A A A temperature of formulation is 80° C. or below

(29) TABLE-US-00007 TABLE 4-2 Comp. Comp. Comp. Comp. Comp. Comp. Comp. Comp. Comp. Comp. Comp. Comp. Comp. compo- Ex. 3- Ex. 3- Ex. 3- Ex. 3- Ex. 3- Ex. 3- Ex. 3- Ex. 3- Ex. 3- Ex. 3- Ex. 3- Ex. 3- Ex. 3- nent component 1-1 1-2 1-3 1-4 1-5 1-6 2 3 4 5 6 7 8 C liquid 25 25 25 25 25 25 25 25 25 25 90 — — paraffin C cetyl 40 40 40 40 40 40 40 — 40 — — 90 ethylhexanoate C wheat germ oil — — — — — — — 40 — 40 — — 90 D PEG-15 25 25 25 25 25 25 25 25 — — — — — hydrogenated castor oil isostearate (HLB 6) D polyglyceryl- — — — — — — — — 25 25 — — — 10 dioleate (HLB 11) A + B formulation of 10 — — — — — — — — — — — — Comparative Example 1-1 A + B formulation of — 10 — — — — — — — — — — — Comparative Example 1-2 A + B formulation of 10 — — — — — — — — — Comparative Example 1-3 A + B formulation of — — — 10 — — — — — — — — — Comparative Example 1-4 A + B formulation of — — 10 10 10 10 10 10 10 Comparative Example 1-5 A + B formulation of — — — — 10 — — — — — — — — Comparative Example 2-1 A + B formulation of — — — — — 10 — — — — — — — Comparative Example 2-2 total (wt %) 100 100 100 100 100 100 100 100 100 100 100 100 100 confirmation A A A A A B B B B B B B B of transparency evaluation of A B A A A B B B B B B B B sweating of formulation uniform mixing B B B B B A A A A A A A A temperature of formulation is 80° C. or below

(30) As shown in Table 4-1, it was confirmed that the compositions of the Examples could be uniformly mixed at not more than 80° C. and were free of sweating phenomenon, and stable gel compositions were obtained. Since the same results were obtained for all of the A+B compositions of Examples 1-1 to 1-8, the results of eight compositions are shown together in one. The same applies to the results of 2-1 to 2-2.

(31) On the other hand, as shown in Table 4-2, even though the dissolution temperature of the gel compositions could be lowered by utilizing polyol, since polyol has poor compatibility with non-polar oil agents, it causes phase separation from oil when added to the oil. Thus, it was found that the stability of the composition was degraded when polyol was used as a solvent (Comparative Examples 3-2 to 3-8).

Experimental Example 4

(32) The IOB value (inorganic value/organic value) which is an index of the polarity of various solvents was calculated by the existing method (Koda Yoshio et al., “new version conceptual diagram.—foundation and application” new version first printing, Japan, Tokyo, SANKYO SHUPPAN CO., Ltd., October 2008, p. 13-26). The IOB value of each solvent is shown in Table 5.

(33) TABLE-US-00008 TABLE 5 IOB = inorganic value fatty acids (I)/organic value (O) Example 4-1 isostearic acid 0.43 Example 4-2 myristic acid 0.54 Example 4-3 capric acid 0.75 Example 4-4 isononanoic acid 0.94 Example 4-5 2-ethylhexanoic acid 1 Example 4-6 12-hydroxystearic acid 0.69 Example 4-7 lactic acid 5 Comparative 2-octyldodecanol 0.26 Example 4-1 Comparative 2-hexyldecyl alcohol 0.32 Example 4-2

Experimental Example 5

(34) Production Method of Formulation (Example 5) Shown in Table 6:

(35) The solid mixture of component group i which was prepared in advance by dissolving uniformly was redissolved by heating at 70° C. The component group ii was separately mixed with heating at 80° C., component group i was added to component group ii, and the mixture was uniformly mixed at 80° C. iii was dissolved in advance, and iii and iv were mixed with heating at 80° C. i+ii was added to iii+iv while stirring by a homomixer (3000 rpm, 80±3° C., 3 min). The mixture was cooled to 30° C. to give a product.

(36) TABLE-US-00009 TABLE 6 Example 5 (wt %) 1 GP-1 1.2 EB-21 0.8 isostearyl alcohol 6.0 myristic acid 5.0 ii polysorbate 60 2.0 sorbeth-30 tetraoleate 0.5 glyceryl stearate (SE) 0.5 cetyl palmitate 3.0 liquid paraffin 3.0 preservative (phenoxyethanol) 0.3 iii polyhydric alcohol (1,3- 7.0 butyleneglycol) flavor (limonene and linalool) q.s. iv water balance Total (wt %) 100
Sensory Evaluation

(37) Good spreadability and absence of stickiness of Example 5 were evaluated by six expert panelists according to the following criteria.

(38) <Good Spreadability>

(39) TABLE-US-00010 1) spreadability is very good 4 points 2) spreadability is good 3 points 3) spreadability is not very good 2 points 4) spreadability is not good 1 point
<Absence of Stickiness>

(40) TABLE-US-00011 1) no stickiness 4 points 2) not sticky 3 points 3) a little sticky 2 points 4) very sticky 1 point

(41) Based on the average evaluation points by the expert panelists, the following determination was made. The results are shown in Table 7.

(42) (A) very preferable: evaluation average points 3.5 or above

(43) (B) rather preferable: evaluation average points 2.5 points to less than 3.5

(44) (C) not very preferable: evaluation average points 1.5 to less than 2.5

(45) (D) not preferable: evaluation average points less than 1.5

(46) Evaluation of Viscosity Reduction at High Temperature

(47) Final products were heated to 40° C. and decrease in viscosity was determined using a B-type viscometer (Digital Viscometer, manufactured by Tokyo Keiki, rotor No. 4, 30 rpm, 30 sec, 25° C.). When the range of decrease in viscosity was within 10% of the viscosity at room temperature, the reduction in viscosity of the formulation at high temperature was judged to be preferable (A). When the decrease in viscosity was larger than 10%, the reduction in viscosity was judged to be unpreferable (B). The results are shown in Table 7.

(48) TABLE-US-00012 TABLE 7 evaluation item evaluation good spreadability A absence of stickiness A viscosity decrease at A high temperature

Experimental Example 6

(49) Evaluation of Degradation of Component

(50) An appropriate amount of component (B) was measured into a glass vial, and an appropriate amount of component (A) was added to component (B). The mixture was heated and stirred in an oil bath to uniformly dissolve component (A) in component (B). The uniformly dissolved solution was cooled by placing at room temperature for not less than 3 hr. Thereafter, each formulation in Table 8 was dissolved at each redissolution temperature and cooled at room temperature for not less than 3 hr. Such redissolution-cooling operation was repeated 5 times. The dissolution temperature and redissolution temperature were measured and shown in Table 8. As dissolved component (A), an amino acid-based gelling agent “GP-1” manufactured by Ajinomoto Co., Inc. was used as dibutyl N-lauroyl-L-glutamide, an amino acid-based gelling agent “EB-21” manufactured by Ajinomoto Co., Inc. was used as dibutyl N-2-ethylhexanoyl glutamide (hereinafter the same), and prepared at GP-1:EB-21=3:2. As for the obtained mixture, six expert panelists visually confirmed coloration of the formulation shown in Table 8 and evaluated according to the following criteria. In addition, about 3 mg of the formulation of Table 8 was put on the tongue and placed in the mouth. The bitterness felt after 30 seconds was evaluated according to the following criteria.

(51) <Absence of Coloration>

(52) TABLE-US-00013 1) absence of coloration 4 points 2) no coloration 3 points 3) a little coloration 2 points 4) high coloration 1 point
<Absence of Bitter Taste>

(53) TABLE-US-00014 1) no bitter taste 4 points 2) not much bitter taste 3 points 3) a little bitter taste was felt 2 points 4) considerable bitter taste was felt 1 point

(54) Based on the average evaluation points by the expert panelists, the following determination was made. The results are shown in Table 8.

(55) (A) very preferable: evaluation average points 3.5 or above

(56) (B) rather preferable: evaluation average points 2.5 points to less than 3.5

(57) (C) not very preferable: evaluation average points 1.5 to less than 2.5

(58) (D) not preferable: evaluation average points less than 1.5

(59) TABLE-US-00015 TABLE 8 Comp. Comp. Example Example Example Example component 6-1 6-2 6-1 6-2 A dibutyl lauroyl 12 12 12 12 glutamide (GP-1) A dibutyl ethylhexanoyl 8 8 8 8 glutamide (EB-21) B isostearic acid 80 — — — B myristic acid — 80 — B oleyl alcohol — — 80 — B 2-octyldodecanol — — — 80 total (wt %) 100 100 100 100 dissolution 90 85 110 120 temperature (° C.) redissolution 65 60 90 100 temperature (° C.) evaluation of A A D A coloration evaluation of bitter A A C C taste

Experimental Example 7

(60) Mixtures (20 g) of (A) and (E) at proportions (wt %) shown in Table 9 were placed in glass vials, and the dissolution temperature and redissolution temperature were measured and evaluated in the same manner as in Experimental Example 1. The compatibility with the oil agent of (E) was evaluated in the same manner as in Experimental Example 1. The results are shown in Table 9.

(61) As component (A), an amino acid-based gelling agent “GP-1” manufactured by Ajinomoto Co., Inc. was used as dibutyl N-lauroyl-L-glutamide, an amino acid-based gelling agent “EB-21” manufactured by Ajinomoto Co., Inc. was used as dibutyl N-2-ethylhexanoyl glutamide (hereinafter the same), and prepared at GP-1:EB-21=3:2.

(62) TABLE-US-00016 TABLE 9 Example Example Example Example Example Example component 1-18 1-19 1-20 1-21 1-22 1-23 A dibutyl lauroyl glutamide 12 12 12 12 12 12 (GP-1) A dibutyl ethylhexanoyl glutamide 8 8 8 8 8 8 (EB-21) E N-decanoylproline 80 — — — — — E N-lauroylsarcosine — 80 — — — — E N-cocoyl alanine — — 80 — — — E N-cocoyl valine — — — 80 — — E N-cocoyl threonine — — — — 80 — E N-octanoyl-N-methyl-β-alanine — — — — — 80 total (wt %) 100 100 100 100 100 100 dissolution temperature (° C.) 80 90 90 90 90 75 redissolution temperature (° C.) 50 70 70 70 60 65 qualitative evaluation of redissolution ⊙ ◯ ◯ ◯ ⊙ ◯ temperature compatibility of various oil agents and ⊙ ⊙ ⊙ ⊙ ⊙ ⊙ solvents

(63) As shown in Table 9, when acylamino acid was used as the solvent, (A) could be dissolved at not more than 90° C. and it was confirmed that the redissolution temperature was as low as 70° C. or below.

(64) Reference formulation examples using the above-mentioned composition I are shown below. These formulations have high stability, the formulations other than Reference formulation 2 have very high transparency, and can impart very smooth texture when in use. In addition, these formulations can be produced at a temperature not higher than 100° C.

(65) TABLE-US-00017 TABLE 10-1 Reference formulation 1 natural lip formulation: component C squalane 63.2 component B hexyldecanol 16 component B myristic acid 4 component A dibutyl lauroyl glutamide (GP-1) 3 component A dibutyl ethylhexanoyl glutamide (EB-21) 2 other dextrin palmitate 1.8 gelling agent component C meadowfoam oil 5 component C almond oil 2 component C macadamia nut oil 2 component C jojoba oil 1 total (wt %) 100

(66) TABLE-US-00018 TABLE 10-2 Reference formulation 2 petrolatum stick formulation: component C petrolatum 60 component C meadowfoam oil 5 component C squalane 2 component B octyldodecanol 18 component B myristic acid 2 component A dibutyl lauroyl glutamide (GP-1) 1.5 component A dibutyl ethylhexanoyl glutamide (EB-21) 1 component C synthetic wax 2.5 other dextrin palmitate 2 gelling agent component C almond oil 2 component C macadamia nut oil 2 component C jojoba oil 1 component C lauroyl glutamic acid 1 di(phytosteryl/octyldodecyl) total (wt %) 100

(67) TABLE-US-00019 TABLE 10-3 Reference formulation 3 lip tint formulation: component B hexyldecanol 16 component B myristic acid 4 component A dibutyl lauroyl glutamide (GP-1) 3 component A dibutyl ethylhexanoyl glutamide (EB-21) 2 component C hydrogenated polyisobutene 50.9 component C triisostearin 17 component C lauroyl glutamic acid 5 di(phytosteryl/octyldodecyl) component C cyclopentasiloxane 2 dye Red 218 0.08 pH adjuster citric acid 0.02 total (wt %) 100

(68) TABLE-US-00020 TABLE 10-4 Reference formulation 4 clear lipstick formulation: component B octyldodecanol 16 component B myristic acid 4 component A dibutyl lauroyl glutamide (GP-1) 3 component A dibutyl ethylhexanoyl glutamide (EB- 21) 2 component C hydrogenated polyisobutene 51 component C triisostearin 17 component C lauroyl glutamic acid 5 di(phytosteryl/octyldodecyl) component C cyclopentasiloxane 2 total (wt %) 100

(69) TABLE-US-00021 TABLE 10-5 Reference formulation 5 sun care stick formulation: component C di(capuryl/capric acid)BG 23.5 component C diisostearyl malate 10 other dextrin palmitate 3 gelling agent UV absorber ethylhexyl methoxycinnamate 10 UV absorber bisethylhexyloxyphenolmethoxyphenyltriazine 6 UV absorber ethylhexyl salicylate 5 UV absorber octocrylene 5 component C bisphenylpropyldimethicone 2 component C almond oil 1 component C meadowfoam oil 5 component C macadamia nut oil 2 component C squalane 1 component C lauroyl glutamic acid 1 di(phytosteryl/octyldodecyl) component B hexyldecanol 16 component B myristic acid 4 component A dibutyl lauroyl glutamide (GP-1) 3 component A dibutyl ethylhexanoyl glutamide (EB-21) 2 flavor 0.5 total (wt %) 100

INDUSTRIAL APPLICABILITY

(70) Using the composition of the present invention, cosmetics and the like with beautiful appearance can be produced easily without damaging the components to be blended in cosmetic, perfumery, quasi-drug and the like.

DESCRIPTION

Title of the Invention: GEL COMPOSITION

TECHNICAL FIELD

(71) The present invention relates to a composition containing N-acyl acidic amino acid dialkylamide, more specifically a gel composition, and a production method thereof.

BACKGROUND ART

(72) Molecules of amino acid derivatives having three or more amide bonds such as dibutyl N-lauroyl-L-glutamide and dibutyl N-2-ethylhexanoyl glutamide are capable of gelling oils and are used for shape stabilization and texture improvement of solid cosmetics and liquid cosmetics. When gelling an oil by using an amino acid-based gelling agent having many amide bonds, it is necessary to first uniformly dissolve these molecules in oil. However, it is known that heating at very high temperature is necessary to uniformly dissolve these gelling agents in oil and the handling in manufacturing is difficult (patent document 1′).

(73) To blend a gel having a certain degree of strength, it is necessary to add a gelling agent at not less than a certain concentration to oil. When the concentration of the gelling agent in the oil is higher, the temperature of heating necessary to dissolve the gelling agent becomes higher.

(74) For example, the dissolution temperature of dibutyl N-2-ethylhexanoyl glutamide in general oils such as liquid paraffin is as high as 150° C. (when 1 wt % of gelling agent is dissolved) −180° C. (when 2 wt % of gelling agent is dissolved). Uniform mixing in an oily base requires dissolution by heating at a very high temperature condition of not less than 150° C. When dibutyl N-2-ethylhexanoyl glutamide is added to an oily cosmetic base, therefore, other ingredients are problematically degraded or inactivated or evaporated by the influence of heat.

(75) To solve this problem, attempts have been made to gelate oil or an oil-containing formulation by previously dissolving a gelling agent in a solvent superior in dissolving gelling agents and adding this solution into the oil. As a solvent for dissolving a gelling agent, higher alcohols, for example, isostearyl alcohol, 2-octyldodecanol and oleyl alcohol have been used. In addition, polyol-type solvents, particularly, diol solvent, has also been used (patent documents 2′, 3′). Even when these solvents are used, the dissolution temperature of the gelling agent is 100° C.-120° C., and a high temperature is necessary.

(76) Incidentally, it has been reported that a dissolution temperature of a gelling agent can be lowered to 70° C.-100° C. by simultaneously utilizing dipropyleneglycol as polyol and octyldodecanol as a higher alcohol (patent document 4′, [0073] etc.). However, with this technique, the total concentration of the gelling agent that can be dissolved in the mixed solvent is small, and not less than 12 wt % of a gelling agent (total amount of gelling agent/total amount of solvent=12 wt %) could not be dissolved (patent document 4′, Example 1). When a gelling agent is dissolved by this technique, however, 26-30 wt % of a solvent problematically remains in the formulation as a solvent of the gelling agent (Examples 1 and 2 of patent document 4′). Furthermore, when polyol is used as a solvent, problems also occur such as a decrease in the stability of the formulation and the like.

(77) Further studies have been made to lower the dissolution temperature of the gelling agent by using 3-methoxy-3-methylbutanol which is a lower alcohol (Example 3 of patent document 5′). In this case, however, the concentration of the gelling agent that can be dissolved is limited. That is, only 10 wt % of a gelling agent could be dissolved in 90 wt % of a solvent. Furthermore, 3-methoxy-3-methylbutanol has a boiling point of 174° C. and cannot be removed easily from the formulation.

(78) It is known that lower alcohol such as ethanol is used in emulsion cosmetic which is a cosmetic containing water (patent documents 6′, 7′). In patent document 6′, however, dissolution of not less than 20 wt % of a gelling agent at not more than 80° C. or uniform dissolution of a formulation at not more than 80° C. was not realized. In patent document 7′, not less than 20 wt % of water was contained in the gel composition, the final form was in a liquid form, and a gel composition having high breaking strength was not obtained.

(79) As mentioned above, in the conventional technique, when a powder of a gelling agent is added to a solvent and mixed by heating at 80° C. or below, dissolution of not less than 20 wt % of the gelling agent in the solvent is considered to be difficult. In view of the merit that the concentration of a solvent remaining in the final formulation can be reduced by dissolving a gelling agent at a higher concentration in a solvent, it is desired to dissolve a gelling agent at a high concentration in a solvent. In the production of cosmetic and the like, dissolution of a gelling agent at a temperature of 80° C. or below is a preferable condition. Thus, the development of a technique for dissolving a high concentration of a gelling agent at a lower temperature and blending same has been desired (patent document 4′).

Document List

Patent Documents

(80) patent document 1′: WO2013/118921 patent document 2′: WO2011/112799 patent document 3′: U.S. Pat. No. 8,999,304 patent document 4′: US20090317345 patent document 5′: WO2003102104 patent document 6′: US20120264742 patent document 7′: U.S. Pat. No. 8,591,871

SUMMARY OF THE INVENTION

Problems to be Solved by the Invention

(81) The problem of the present invention is to provide a gelling agent mixture optimal for the production of gel cosmetics and the like by dissolving a high concentration of a gelling agent at a lower temperature.

Means of Solving the Problems

(82) In view of the above-mentioned problems, the present inventors have conducted intensive studies and found for the first time that, when a solvent having a low boiling point (not more than 120° C.) is used, a high dose of a gelling agent can be dissolved at a temperature considerably lower than that in general solvents, and that when an oil is gelled using a gelling agent dissolved in the solvent, a gel formulation (composition) with good stability (free of sweating) can be formed. Surprisingly, moreover, they have found that the gel formulation (composition) after removal of the solvent has extremely high strength, which resulted in the completion of the present invention.

(83) That is, the present invention includes the following embodiments.

(84) [1] A composition comprising

(85) (A′) at least one kind of N-acyl acidic amino acid dialkylamide represented by the formula (I):

(86) ##STR00007##
wherein R.sup.1 and R.sup.2 are each independently a straight chain or branched chain alkyl group having 1-7 carbon atoms, R.sup.3 is a straight chain or branched chain alkyl group having 3-15 carbon atoms, and n is 1 or 2), and (B′) a solvent having a boiling point of not more than 120° C., and having a water content of not more than 2 wt % relative to the total weight of the composition.
[2] The composition of [1], wherein N-acyl acidic amino acid dialkylamide represented by the formula (I) is at least one kind selected from the group consisting of dibutyl N-2-ethylhexanoyl glutamide and dibutyl N-lauroyl glutamide.
[3] The composition of [1], wherein N-acyl acidic amino acid dialkylamide represented by the formula (I) comprises dibutyl N-2-ethylhexanoyl glutamide and dibutyl N-lauroyl glutamide.
[4] The composition of any of [1]-[3], wherein (B′) is a lower alcohol.
[4-1] The composition of [4], wherein (B′) is at least one kind of lower alcohol selected from the group consisting of ethanol, 1-propanol, isopropyl alcohol, tert-butyl alcohol, 1-butyl alcohol and 2-butyl alcohol.
[4-2] The composition of [4], wherein (B′) is at least one kind of lower alcohol selected from the group consisting of ethanol, isopropyl alcohol and tert-butyl alcohol.
[5] The composition of any of [1] to [4], comprising 0.1-6 parts by weight of (B′) per 1 part by weight of (A′).
[6] The composition of any of [1] to [5], having a water content of 0.1-1.5 wt % relative to the total weight of the composition.
[6-1] The composition of any of [1] to [5], wherein the composition is a gel.
[6-2] The composition of any of [1] to [5], wherein the composition is a gelling agent.
[7] The composition of any of [1] to [6], wherein the redissolution temperature is not more than 80° C.
[8] A gel composition comprising the composition of any of [1] to [7] and (C′) an oil agent.
[8-1] The gel composition of [8], wherein the (C′) oil agent is at least one selected from the group consisting of liquid paraffin, cetyl ethylhexanoate, isopropyl myristate, tri(caprylic acid/capric acid)glyceryl, wheat germ oil and shea butter.
[9] The gel composition of [8], comprising (A′) 0.1-20 wt %, (B′) 0.15-50 wt % and (C′) 20-99.7 wt %, relative to the total weight of the gel composition.
[10] The gel composition of [8] or [9], further comprising (D′) an emulsifier.
[10-1] The gel composition of [10], wherein (D′) emulsifier is at least one selected from the group consisting of polyglyceryl-10 dioleate, PEG-8 glyceryl isostearate, polyglyceryl-10 cocoate, polyglyceryl-3 cocoate, PEG-40 glyceryl triisostearate, PEG-40 glyceryl isostearate, PEG-50 hydrogenated castor oil isostearate, polysorbate 60, sorbeth-30 tetraoleate, glyceryl stearate (SE) and PEG-15 hydrogenated castor oil isostearate.
[11] The gel composition of [10], comprising (A′) 0.1-10 wt %, (B′) 0.15-15 wt %, (C′) 30-89 wt % and (D′) 2-68 wt %, relative to the total weight of the gel composition.
[12] The composition of any of [1] to [11], wherein the composition is used for cosmetic, perfumery or quasi-drug.
[13] A composition comprising the above-mentioned components (A′) and (B′), wherein a content of (A′) on charging is 10-60 wt % and a content of (B′) on charging is 40-90 wt %.
[14] A gel composition comprising the above-mentioned components (A′), (B′) and (C′), wherein a content of (A′) on charging is 0.5-10 wt % and a content of (B′) on charging is 0.5-50 wt %, and a content of (C′) on charging is 30-99 wt %.
[15] The gel composition of [14], further comprising the above-mentioned (D′), wherein a content of (C′) on charging is 30-95 wt % and a content of (D′) on charging is 2-68 wt %.
[16] A method for producing a composition comprising the above-mentioned (A′) and (B′), comprising a step of dissolving (A′) in (B′) at not more than 85° C.
[17] The method of [16], wherein the amount of (A′) in the step of dissolving (A′) in (B′) at not more than 85° C. is 10-60 wt % relative to the total weight of (A′) and (B′).
[18] The method of [16] or [17], wherein the composition containing (A′) and (B′) is a gel composition comprising (A′), (B′) and (C′) an oil agent, the method further comprising a step of dissolving, in (C′) the oil agent, a dissolution product obtained by dissolving (A′) in (B′), wherein the amount of (A′) and (B′) in the step is 0.1-60 wt % relative to the total weight of (A′), (B′) and (C′).
[19] The method of [18], comprising a step of adding 0.1-70 wt % of (D′) an emulsifier relative to the total weight of the gel composition.
[20] The method of [18] or [19], comprising a step of removing (B′) at not more than 120° C. from the gel composition.
[21] A composition obtained by the production method of any of the above-mentioned [16] to [20].
[22] A gel composition obtained by dissolving dibutyl N-2-ethylhexanoyl glutamide and dibutyl N-lauroyl glutamide in ethanol at not more than 85° C., dissolving the dissolution product in (C′) and (D′), and removing ethanol from the obtained dissolution product.

Effect of the Invention

(87) The gel composition of the present invention can be applied to various products since the solvent in the composition can be easily removed as necessary.

(88) By removing the solvent, a gel product having a higher gel strength can be provided.

(89) According to the present invention, a highly stable gel composition in which a sweating (sweating phenomenon) is suppressed can be provided.

(90) According to the present invention, a gel composition capable of blending even components degraded at a high temperature and components volatilized at a high temperature such as flavor to cosmetics and the like can be provided.

(91) When the gel composition of the present invention s used for producing cosmetics and perfumery, a conventional treatment at a very high temperature is not necessary, easy production is possible, and production steps of cosmetics and the like can be simplified drastically.

Description of Embodiments

(92) The present invention relates to a composition comprising containing (A′) N-acyl acidic amino acid dialkylamide and (B′) a solvent having a boiling point of 120° C. or below, and having a water content of not more than 2 wt %.

(93) (A′) N-acyl acidic amino acid dialkylamide

(94) In the present invention, N-acyl acidic amino acid dialkylamide (A′) is represented by the formula (I):

(95) ##STR00008##
wherein R.sup.1 and R.sup.2 are each independently a straight chain or branched chain alkyl group having 1-7 carbon atoms. Examples of the straight chain or branched chain alkyl group having 1-7 carbon atoms include methyl group, ethyl group, isopropyl group, propyl group, butyl group, isobutyl group, sec-butyl group, tert-butyl group, pentyl group, sec-pentyl group, tert-pentyl group, isopentyl group, hexyl group, and heptyl group and the like. Since an effective gel strength can be exhibited with a small amount, a straight chain or branched chain alkyl group having 3-5 carbon atoms is preferable, and a butyl group is more preferable. It is more preferable that both R.sup.1 and R.sup.2 be straight chain or branched chain alkyl groups having 3-5 carbon atoms, and it is further preferable that both R.sup.1 and R.sup.2 be butyl groups.

(96) In the formula, R.sup.3 is a straight chain or branched chain alkyl group having 3-15 carbon atoms. Examples of the straight chain or branched chain alkyl group having 3-15 carbon atoms include propyl group, isopropyl group, butyl group, isobutyl group, sec-butyl group, tert-butyl group, pentyl group, sec-pentyl group, tert-pentyl group, isopentyl group, hexyl group, heptyl group, 1-ethylpentyl group, octyl group, 2-ethylhexyl group, tert-octyl group, nonyl group, isononyl group, decyl group, isodecyl group, undecyl group, dodecyl group, tridecyl group, isotridecyl group, tetradecyl group, and pentadecyl group and the like. Since an effective gel strength can be exhibited with a small amount, a straight chain or branched chain alkyl group having 5-13 carbon atoms is preferable, a straight chain or branched chain alkyl group having 7-11 carbon atoms is more preferable, and a 1-ethyl pentyl group or an undecyl group is most preferable.

(97) n is 1 or 2. When n is 1, (A′) is N-acyl aspartic acid dialkylamide, and when n is 2, (A′) is N-acyl glutamic acid dialkylamide. Since an effective gel strength can be exhibited with a small amount, n is preferably 2 (N-acylglutamic acid dialkylamide).

(98) Specific examples of the N-acyl acidic amino acid dialkylamide (A′) include diisopropyl N-hexanoyl glutamide, dibutyl N-hexanoyl glutamide, di-sec-butyl N-hexanoyl glutamide, diisobutyl N-hexanoyl glutamide, diisopropyl N-octanoyl glutamide, dibutyl N-octanoyl glutamide, di-sec-butyl N-octanoyl glutamide, diisobutyl N-octanoyl glutamide, dimethyl N-2-ethyl hexanoyl glutamide, diethyl N-2-ethylhexanoyl glutamide, dipropyl N-2-ethylhexanoyl glutamide, diisopropyl N-2-ethylhexanoyl glutamide, dibutyl N-2-ethylhexanoyl glutamide, di-sec-butyl N-2-ethylhexanoyl glutamide, diisobutyl N-2-ethylhexanoyl glutamide, dipentyl N-2-ethylhexanoyl glutamide, dihexyl N-2-ethylhexanoyl glutamide, diisopropyl N-decanoyl glutamide, dibutyl N-decanoyl glutamide, di-sec-butyl N-decanoyl glutamide, diisobutyl N-decanoyl glutamide, dimethyl N-lauroyl glutamide, diethyl N-lauroyl glutamide, dipropyl N-lauroyl glutamide, diisopropyl N-lauroyl glutamide, dibutyl N-lauroyl glutamide, di-sec-butyl N-lauroyl glutamide, diisobutyl N-lauroyl glutamide, dipentyl N-lauroyl glutamide, dihexyl N-lauroyl glutamide, diisopropyl N-palmitoyl glutamide, dibutyl N-palmitoyl glutamide, di-sec-butyl N-palmitoyl glutamide, diisobutyl N-palmitoyl glutamide, diisopropyl N-myristoyl glutamide, dibutyl N-myristoyl glutamide, di-sec-butyl N-myristoyl glutamide, diisobutyl N-myristoyl glutamide, diisopropyl N-2-ethylhexanoyl aspartamide, dibutyl N-2-ethylhexanoyl aspartamide, di-sec-butyl N-2-ethylhexanoyl aspartamide, diisobutyl N-2-ethylhexanoyl aspartamide, diisopropyl N-lauroyl aspartamide, dibutyl N-lauroyl aspartamide, di-sec-butyl N-lauroyl aspartamide, and diisobutyl N-lauroyl aspartamide, preferably, diisopropyl N-2-ethylhexanoyl glutamide, dibutyl N-2-ethylhexanoyl glutamide, di-sec-butyl N-2-ethylhexanoyl glutamide, diisobutyl N-2-ethylhexanoyl glutamide, diisopropyl N-lauroyl glutamide, dibutyl N-lauroyl glutamide, di-sec-butyl N-lauroyl glutamide and diisobutyl N-lauroyl glutamide. More preferred are dibutyl N-2-ethylhexanoyl glutamide and dibutyl N-lauroyl glutamide.

(99) As (A′), one or more kinds of N-acyl acidic amino acid dialkylamides can also be used.

(100) As (A′), dibutyl N-2-ethylhexanoyl glutamide (A′1) and dibutyl N-lauroyl glutamide (A′2) are preferable. When (A′1) and (A′2) are used, the weight ratio thereof (A′1):(A′2) is not particularly limited. It is generally 1:20-20:1, preferably 1:9-9:1, more preferably 1:4-4:1, further preferably 2:3.

(101) The N-acyl acidic amino acid dialkylamide represented by the formula (I) may be a stereoisomer such as optical isomer, diastereomer and the like, a mixture of any stereoisomers, or racemate.

(102) (B′) Solvent Having Boiling Point of not More than 120° C.

(103) (B′) in the present invention is an organic solvent having a boiling point of not more than 120° C. at normal pressure. When the boiling point of the solvent is too low, the solvent is difficult to handle in the production step, and a solvent having a low boiling point sometimes lacks preservation stability. Thus, the boiling point is generally not more than 120° C., preferably not more than 100° C., more preferably not more than 85° C., and the lower limit is generally not less than 5° C., preferably not less than 25° C., more preferably not less than 40° C.

(104) (B′) in the present invention is not particularly limited as long as it has a boiling point of not more than 120° C., and a solvent generally used for cosmetic, pharmaceutical product and the like is preferable, and alcohol can be mentioned.

(105) As alcohol, lower alcohol is preferable, and monovalent lower alcohol is more preferable.

(106) The lower alcohol is preferably an alcohol having not more than 5 carbon atoms. From the aspects of dissolution property, easy removal of the solvent and the like, an alcohol having not more than 4 carbon atoms is more preferable. Specifically, ethanol (78.4° C.), 1-propanol (97° C.), isopropyl alcohol (2-propanol) (82.4° C.), tert-butyl alcohol (82.4° C.), 1-butyl alcohol (117.4° C.), 2-butyl alcohol (98° C.) and the like can be mentioned, ethanol, isopropyl alcohol, tert-butyl alcohol are preferable, and ethanol is more preferable.

(107) The values in the above-mentioned parentheses show a boiling point of each solvent at normal pressure. These solvents may be used alone or in combination.

(108) The content of (B′) in the composition I of the present invention is generally not more than 6 parts by weight, preferably not more than 2 parts by weight, more preferably not more than 0.6 parts by weight, and generally not less than 0.01 parts by weight, preferably not less than 0.05 part by weight, more preferably not less than 0.1 parts by weight, per 1 part by weight of (A′), from the aspects of low dissolution temperature, flame retardancy and stability of the composition.

(109) From the aspects of stability of the composition and low dissolution temperature, the composition containing (A′) and (B′) generally contains (A′) 0.1-60 wt % and (B′) 0.1-90 wt %, preferably (A′) 1-40 wt % and (B′) 0.5-80 wt %, more preferably (A′) 1-30 wt % and (B′) 0.5-80 wt %, further preferably (A′) 5-20 wt % and (B′) 1-70 wt %, relative to the total weight of the composition.

(110) For example, when (A′) is a gelling agent at (A′1):(A′2)=2:3 and (B′) is ethyl alcohol, a composition containing not less than 30 wt % of (A′) and 60 wt % of (B′) is preferable.

(111) In the present invention, the composition containing (A′) and (B′) has a water content of generally not more than 2 wt %, preferably 0.1-1.5 wt %, more preferably 0.5-1 wt %, relative to the total weight of the composition.

(112) In the present invention, the composition containing (A′) and (B′) is uniformly dissolved at generally not more than 85° C., more preferably not more than 80° C.

(113) A gel composition containing a composition containing (A′) and (B′) and (C′) an oil agent (hereinafter sometimes to be abbreviated as the gel composition of the present invention) is also encompassed in the present invention.

(114) (C′) Oil agent

(115) (C′) in the present invention can be used without particularly restriction as long as it is an oil agent used for cosmetic, pharmaceutical products and the like. Examples thereof include liquid oil agent, semisolid oil agent, solid oil agent and the like, with preference given to a liquid oil agent.

(116) Specifically, liquid oil agent such as straight chain or branched hydrocarbon oil such as liquid paraffin, light isoparaffin, liquid isoparaffin, squalane, squalene and the like; vegetable oils such as shea butter, almond oil, jojoba oil, olive oil, jojoba seed oil, maize germ oil, wheat germ oil, meadowfoam oil, sunflower oil and the like; animal-derived fats and oils such as liquid lanolin and the like; ester oils such as fatty acid ester, polyhydric alcohol fatty acid ester (e.g., isopropyl myristate, cetyl ethylhexanoate, ethylhexyl palmitate, cetyl palmitate, isopropyl palmitate, tri(caprylic acid/capric acid)glyceryl, triethylhexanoin and the like); acylamino acid esters such as isopropyl lauroyl sarcosine (Eldew (registered trade mark) SL-205), N-lauroyl-L-glutamic acid di(cholesteryl/octyldodecyl), hexyldecyl myristoyl methyl aminopropionate, dihexyldecyl lauroyl glutamate, diisostearyl lauroyl glutamate, dioctyldodecyl lauroyl glutamate, lauroyl glutamic acid bis(hexyldecyl/octyldodecyl), dioctyldodecyl lauroyl glutamate, dioctyldodecyl stearoyl glutamate and the like; phytosterol esters such as N-lauroyl-L-glutamic acid di(phytosteryl/2-octyldodecyl) and the like; silicone oil such as cyclopentasiloxane, dimethylpolysiloxane, dimethylcyclopolysiloxane, methylphenylpolysiloxane, methyl hydrogen polysiloxane, higher alcohol denatured organopolysiloxane and the like, silicone oil of fluorine oil such as fluoropolyether, perfluoro alkylethersilicone and the like, and the like;

(117) semisolid oil agent such as cholesteryl esters such as cholestryl isostearate, cholestryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, N-lauroyl-L-glutamic acid di(cholesteryl/behenyl/octyldodecyl) and the like; phytosterol esters such as N-lauroyl-L-glutamic acid di(phytosteryl/behenyl/2-octyldodecyl), myristoylmethyl-β-alanine(phytosteryl/decyltetradecyl)isostearic acid phytosteryl, phytosteryl oleate and the like; dipentaerythrityl fatty acid esters such as dipentaerythrityl hexaoxystearate, dipentaerythrityl rosinate and the like; triglycerides such as tri(caprylic acid/capric acid)glyceryl, tri(capuryl/capric/myristic/stearic acid) glycerides and the like; partially hydrogenated triglycerides such as hydrogenated oil and the like; lanolin, lanosterols, petrolatum and the like;
solid oil agents such as animal-derived wax, plant-derived wax, mineral wax, synthetic wax, specifically, rice bran wax, carnauba wax, candelilla wax, beeswax, spermaceti, ceresin, solid paraffin, microcrystalline wax, polyethylene wax, polyolefinwax and the like.

(118) Among these, from the aspect of broad utility, hydrocarbon oils such as petrolatum, solid paraffin, liquid paraffin and the like; silicone oil such as cyclopentasiloxane and the like; fatty acid ester oils such as cetyl ethylhexanoate, ethylhexyl palmitate, isopropyl myristate, isopropyl palmitate, tri(caprylic acid/capric acid)glyceryl, triethylhexanoin and the like; vegetable oils such as shea butter, almond oil, wheat germ oil, jojoba seed oil, olive oil, meadowfoam oil and the like; phytosterol esters such as N-lauroyl-L-glutamic acid di(phytosteryl/2-octyldodecyl) and the like, acylamino acid ester oil such as isopropyl lauroylsarcosine and the like, and the like are preferable, liquid paraffin, cetyl ethylhexanoate, isopropyl myristate, tri(caprylic acid/capric acid)glyceryl, wheat germ oil, shea butter and the like are preferable, and cetyl ethylhexanoate, isopropyl myristate, tri(caprylic acid/capric acid)glyceryl, and wheat germ oil are more preferable.

(119) Among these, fatty acid ester oil such as ethylhexyl palmitate, isopropyl myristate, isopropyl palmitate, tri(caprylic acid/capric acid)glycerides, triethylhexanoin and the like, mineral oil such as liquid paraffin and the like, vegetable oil such as wheat germ oil and the like, shea butter and the like are preferable from the aspects of stability of the composition and a light sense of use.

(120) The content of (C′) in the gel composition of the present invention is generally not less than 20 wt %, preferably not less than 30 wt %, more preferably 40 wt %, further preferably not less than 50 wt %, and the upper limit is generally not more than 99.9 wt %, preferably not more than 95 wt %, more preferably not more than 90 wt %, further preferably not more than 85 wt %, relative to the total weight of the gel composition, since a stable gel composition with a low dissolution temperature, a high gel strength and less sweating can be obtained.

(121) The gel composition generally contains (A′) 0.1-20 wt %, (B′) 0.15-50 wt % and (C′) 20-99.7 wt %, preferably (A′) 0.5-8 wt %, (B′) 0.5-12 wt % and (C′) 30-95 wt %, more preferably (A′) 1-5 wt %, (B′) 0.75-5 wt % and (C′) 50-90 wt %, relative to the total weight of the gel composition containing (A′)+(B′)+(C′), since a stable gel composition with a low dissolution temperature, a high gel strength and less sweating can be obtained.

(122) In the gel composition of the present invention, the stability (no sweating) of the gel composition can be improved by adding (D′) emulsifier in addition to the above-mentioned (A′)-(C′).

(123) (D′) Emulsifier

(124) (D′) in the present invention is not particularly limited as long as it is used for cosmetics, pharmaceutical products and the like, and nonionic emulsifiers can be mentioned.

(125) Among the nonionic emulsifiers, nonionic emulsifiers generally having HLB 5-16 or HLB 5-17 are used from the aspect of compatibility with oil. Among those, from the aspect of less sweating of formulation and improved stability, emulsifiers having HLB 8-17 are preferable, emulsifiers having HLB 8-16 are more preferable, emulsifiers having HLB 10-16 are further preferable.

(126) It is also possible to use a mixture of a nonionic surfactant having a low HLB and a surfactant having a high HLB.

(127) Examples of the emulsifier with HLB 10-16 include sorbeth-60 tetraoleate (tetraoleic acid polyoxyethylene(60)sorbit), PEG-8 glyceryl isostearate, PEG(polyethylene glycol)-7 glyceryl cocoate, polyglyceryl-10 dioleate, polyglyceryl-10 diisostearate, polyglyceryl-10 trilaurate, hexaglyceryl tricaprylate, polyglyceryl-10 cocoate, polyglyceryl-3 cocoate, PEG(polyethylene glycol)-40 glyceryl triisostearate, PEG(polyethylene glycol)-40 glyceryl isostearate, PEG(polyethylene glycol)-50 hydrogenated castor oil isostearate, polysorbate 60, sorbeth-30 tetraoleate, glyceryl stearate (SE: self-emulsifying type). Examples of the emulsifier with HLB 17 include PEG(polyethylene glycol)-100 stearate.

(128) Examples of the emulsifier with HLB 5—less than 10 include polyglyceryl-2 stearate, polyglyceryl-2 oleate, polyglyceryl-2 sesquicaprylate, PEG(polyethylene glycol)-20 glyceryl triisostearate, PEG(polyethylene glycol)-15 hydrogenated castor oil isostearate, PEG-6 sorbitan oleate.

(129) Among these, polyglyceryl-10 dioleate, PEG-8 glyceryl isostearate, polyglyceryl-10 cocoate, polyglyceryl-3 cocoate, PEG-40 glyceryl triisostearate, PEG-40 glyceryl isostearate, PEG-50 hydrogenated castor oil isostearate, polyglyceryl-2 oleate, polysorbate 60, sorbeth-30 tetraoleate, glyceryl stearate (SE: self-emulsifying type), PEG-15 hydrogenated castor oil isostearate is preferable, polyglyceryl-10 dioleate, PEG-8 glyceryl isostearate, polyglyceryl-10 cocoate, polyglyceryl-3 cocoate, PEG-40 glyceryl triisostearate, PEG-40 glyceryl isostearate, PEG-50 hydrogenated castor oil isostearate, polysorbate 60, sorbeth-30 tetraoleate, glyceryl stearate (SE: self-emulsifying type), PEG-15 hydrogenated castor oil isostearate are more preferable, and polyglyceryl-10 dioleate, polyglyceryl-10 cocoate, PEG-40 glyceryl triisostearate and polysorbate 60 are particularly preferable.

(130) The content of (D′) in the gel composition of the present invention is generally not less than 2 wt %, preferably not less than 5 wt %, more preferably 10 wt %, further preferably not less than 15 wt %, and the upper limit is generally not more than 80 wt %, preferably not more than 50 wt %, more preferably not more than 40 wt %, further preferably not more than 30 wt %, relative to the total weight of the gel composition, from the aspects of the stability and cleansing function of the composition.

(131) The gel composition generally contains (A′) 0.1-10 wt %, (B′) 0.15-15 wt %, (C′) 30-89 wt % and (D′) 2-68 wt %, preferably (A′) 0.5-8 wt %, (B′) 0.5-12 wt %, (C′) 40-87 wt % and (D′) 5-50 wt %, more preferably (A′) 1-5 wt %, (B′) 0.75-5 wt %, (C′) 50-80 wt % and (D′) 15-30 wt %, relative to the total weight of the gel composition containing (A′)+(B′)+(C′)+(D′), from the aspects of the stability of the composition and removal of dirt on the skin.

(132) In the gel composition of the present invention, (B′) may be removed from the gel composition depending on the object of use. (B′) can be removed easily by only heating at not more than 120° C., preferably not more than 110° C., more preferably not more than 100° C. For example, to increase gel strength, the content of (B′) is preferably 0.01-1 wt %, more preferably 0.05-0.5 wt %, relative to the total weight of the gel composition.

(133) While the form (shape) of the gel composition of the present invention is not particularly limited, it is, for example, particle, solid, stick, sphere, sheet or the like. Among these, solid or sphere is preferable.

(134) The composition and gel composition of the present invention are characteristically produced by blending components (A′) and (B′), (A′)-(C′), (A′)-(D′) at the below-mentioned dose at the time of charging. For example, the object gel composition can be obtained by dissolving (A′) in (B′) at the below-mentioned temperature, adding a part or the total amount of the solution to (C′) or (C′) and (D′) heated in advance at a certain temperature, stirring the mixture with heating until a uniform solution is formed, and thereafter cooling the mixture.

(135) In the composition containing components (A′) and (B′), the contents at the time of charging are generally (A′) 10-60 wt % and (B′) 40-90 wt %, preferably (A′) 20-50 wt % and (B′) 50-80 wt %, more preferably (A′) 30-40 wt % and (B′) 60-70 wt %, relative to the total weight of the composition containing (A′) and (B′).

(136) In the gel composition containing components (A′)-(C′), the contents at the time of charging are generally (A′) 0.5-10 wt %, (B′) 0.5-50 wt % and (C′) 30-99 wt %, preferably (A′) 1-8 wt %, (B′) 1-40 wt % and (C′) 40-98 wt %, more preferably (A′) 2-5 wt %, (B′) 2-25 wt % and (C′) 60-96 wt %, relative to the total weight of the composition containing (A′)-(C′).

(137) In the gel composition containing components (A′)-(D′), the contents at the time of charging are generally (A′) 0.5-10 wt %, (B′) 0.5-49 wt %, (C′) 30-95 wt % and (D′) 2-68 wt %, preferably (A′) 1-8 wt %, (B′) 1-40 wt %, (C′) 40-90 wt % and (D′) 5-50 wt %, more preferably (A′) 2-5 wt %, (B′) 2-20, (C′) 50-80 wt % and (D′) 12-30 wt %, relative to the total weight of the composition containing (A′)-(D′).

(138) The pH at the time of charging of the composition of the present invention is generally more than pH 3 and less than 9, preferably not less than 4, more preferably not less than 5, further preferably not more than 8, more preferably not more than 7.5.

(139) In the present specification, the temperature at which the composition of the present invention as solid or gel is heated again to give a uniform solution is indicated as “redissolution temperature”.

(140) The redissolution temperature (melting point) of the composition containing (A′) and (B′) of the present invention is generally not more than 80° C., preferably not more than 78° C., more preferably not more than 75° C. Therefore, when used for producing cosmetics and perfumery, a conventional treatment at a very high temperature is not necessary, cosmetic and the like can be produced easily, and production steps of cosmetics and the like can be simplified drastically.

(141) In addition, the gel composition of the present invention can also contain components generally usable for cosmetics such as a gelling agent other than (A′) of the present invention, various chelating agents, antiperspirant active ingredient, surfactants other than nonionic emulsifiers, various additives, various powders, and the like within the range where the effect of the present invention is not inhibited.

(142) While various chelating agents are not particularly limited, preferable examples include a chelator selected from the group consisting of triethylenetetramine, 2-thenoyltrifluoroacetone, thioglycolic acid, tartaric acid, succinic acid, 8-quinolinol, pyridine-2,6-dicarboxylic acid, pyridine, 1,10-phenanthroline, lactic acid, 8-hydroxyquinoline-5-sulfonic acid, glycine, 2,2′-pyridylethylenediamine, aurintricarboxylic acid, xylenol orange, 5-sulfosalicyl acid, salicylic acid, pyrocatechol-3,5-disulfonate, 4,5-dihydroxybenzene-1, 3-disulfonic acid, 1,2-diaminocyclohexane-N,N,N′,N′-tetraacetic acid, citric acid, oxalate, nitrilotriacetic acid, ethylenediamine-N,N,N′,N′-tetraacetic acid, acetylacetone, and salts thereof and a mixture thereof and the like.

(143) Examples of the antiperspirant active ingredient include one kind selected from the group consisting of aluminum chlorohydrate, aluminum chloride, aluminum chlorohydrate allantoinate, aluminum sulfate, zinc oxide, zinc para-phenolsulfonate, and zirconium aluminum complex produced by reacting zirconylchloride with aluminum hydroxide and aluminumchlorohydroxide, and a mixture thereof. As used herein, the antiperspirant active ingredient refers to a component that suppresses sweating by causing strong adstriction of the skin.

(144) Examples of the surfactant other than nonionic emulsifier include anionic surfactant such as N-long chain acylamino acid salts such as N-long chain acylglutamate, N-long chain acylglycine salt, N-long chain acylalanine salt, N-long chain acyl-N-methyl-β-alanine salt and the like, N-long chain fatty acid acyl-N-methyltaurine salt, alkylsulfate and alkyleneoxide adduct thereof, fatty acid amide ether sulfate, metal salt or weak base salt of fatty acid, sulfosuccinic acid-based surfactant, alkyl phosphate and alkyleneoxide adduct thereof, alkylethercarboxylic acid, and the like; non-ionic surfactants such as ether type surfactants such as glycerolether and alkyleneoxide adduct thereof and the like, ether ester type surfactants such as alkylene oxide adduct of glycerolester, alkylene oxide adduct of sorbitan ester, polyoxyalkylene fatty acid ester and the like, ester type surfactants such as glycerol fatty acid ester, fatty acid polyglycerolester, sorbitan fatty acid ester, sucrose fatty acid ester and the like, alkylglucosides such as (caprylyl/capuryl)glucoside and the like, hydrogenated castor oil pyroglutamic acid diester and ethylene oxide adduct thereof, nitrogen-containing type non-ionic surfactants such as fatty acid alkanolamide and the like, and the like; cationic surfactant such as aliphatic amine salt (alkyl ammonium chloride, dialkyl ammonium chloride and the like), aromatic quaternary ammonium salt (quaternary ammonium salt thereof, benzalkonium salt thereof and the like), fatty acid acyl arginine ester, and the like; and amphoteric surfactant such as betaine type surfactant (carboxybetaine and the like), aminocarboxylic acid type surfactant, imidazoline type surfactant and the like, and the like.

(145) Examples of the various additives include amino acids such as glycine, alanine, serine, threonine, arginine, glutamic acid, aspartic acid, isoleucine, leucine, valine and the like; water-soluble polymer such as polyamino acid including polyglutamic acid and polyaspartic acid and a salt thereof, gum arabics, alginates, xanthan gum, chitin, chitosan, water-soluble chitin, carboxyvinyl polymer, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropyltrimethylammonium chloride, polychlorodimethylmethylenepiperidium, polyvinylpyrrolidone derivative, quartenary ammonium cationized protein, collagen decomposed product and a derivative thereof, acylated protein and the like; sugar alcohol such as mannitol and the like and alkylene oxide adduct thereof; animals and plants extract, nucleic acid, vitamin, enzyme, anti-inflammatory agent, antimicrobial agent, preservative, antioxidant, ultraviolet absorber, adiaphoretic, pigment, dye, oxidation dye, pH adjuster, pearly agent, wetting agent and the like, and the like.

(146) Examples of the various powders include resin powder such as nylon beads, silicone beads and the like, nylon powder, metal fatty acid soap, yellow iron oxide, red iron oxide, black iron oxide, chrome oxide, cobalt oxide, carbon black, ultramarine blue, iron blue, zinc oxide, titanium oxide, zirconium oxide, silicon oxide, aluminum oxide, cerium oxide, micatitanium, boron nitride, barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate, magnesium silicate, silicon carbide, dye, lake, sericite, mica, talc, kaolin, plate-shaped barium sulfate, butterfly-shaped barium sulfate, titanium oxide fine particles, zinc oxide fine particles, iron oxide fine particles, acylamino acid such as acyllysine, acylglutamic acid, acylarginine, acylglycine and the like, and the like can be mentioned, which may be further subjected to a surface treatment such as silicone treatment, fluorine compound treatment, silane coupling agent treatment, silane treatment organic titanate treatment, acylation lysine treatment, fatty acid treatment, metal soap treatment, oil treatment, amino acid treatment and the like.

(147) The composition or gel composition of the present invention can be used as it is or as cosmetic, perfumery or quasi-drug after blending the aforementioned components.

(148) The composition or gel composition of the present invention can be used as a base of cosmetic, perfumery, pharmaceutical product, quasi-drug and the like, a texture modifier, a thickener, a stabilizer or a gelling agent. The base refers to a component among the materials of cosmetic and the like, which is mainly used for giving a shape to a product and also called an excipient.

(149) The shape of cosmetic, perfumery, pharmaceutical product or quasi-drug containing the composition II of the present invention is not particularly limited. For example, gel, particle, solid, stick, sphere, sheet can be mentioned. Among these, gel, solid, sphere are preferable, and gel is more preferable.

(150) Specific examples of the cosmetic, perfumery and quasi-drug include solid preparations such as adiaphoretic, chapstick, lip rouge, sun protectant, solid foundation, concealer, foundation primer, cleansing agent and the like, gel or gel dispersions or emulsions such as facial cleanser, cleansing gel, massage cream, cold cream, moisture gel, facial mask, after shaving gel, milky liquid foundation, blush, mascara, shampoo, rinse, hair-growth drug, treatment, conditioner, tic, set lotion, hair cream, hair wax, hair mousse, permanent wave solution, hair dye, hair coloring, hair manicure, sunscreen oil, hand soap and the like, aromatic, cataplasm and the like.

(151) Preferred are adiaphoretic, lip rouge, chapstick, and sun protectant, and more preferred are adiaphoretic, lip rouge, sun protectant, cleansing agent, massage cream, hair coloring agent, and hair wax.

(152) In another embodiment, it is preferably adiaphoretic, lip rouge, chapstick, sun protectant, cleansing agent, massage cream, hair coloring agent or hair wax, and adiaphoretic, lip rouge, sun protectant, cleansing agent, massage cream, hair coloring agent or hair wax is more preferable.

(153) Specific examples of the pharmaceutical product include external preparations such as ointment, cream, gel and the like, adhesive preparation, suppository and the like.

(154) Cosmetic, perfumery, pharmaceutical product and quasi-drug containing the composition or gel composition of the present invention can be produced according to a conventional method.

(155) The present invention also includes a method for producing a composition containing (A′) and (B′), comprising a step of dissolving (A′) in (B′) at not more than 85° C. As described for the above-mentioned compositions, the water content of the composition containing (A′) and (B′) is not more than 2 wt %.

(156) Generally, the amount of (A′) in the step is 10-60 wt %, preferably 20-50 wt %, more preferably 30-40 wt %, relative to the total weight of (A′) and (B′).

(157) The dissolution temperature is generally not more than 85° C., preferably not more than 83° C., more preferably not more than 80° C. The lower limit is generally not less than 20° C., preferably not less than 40° C.

(158) The dissolving is performed by, for example, heating the mixture using an oil bath or a heater.

(159) The time necessary for dissolution is the time necessary for becoming uniform. It is generally 10-120 min, preferably 20-90 min, more preferably 30-60 min. Agitation is applied as necessary. When the mixture becomes uniform, it is cooled to give a gel composition. The definition and the like of each component are as described above.

(160) The above-mentioned production method further contains a step of dissolving the obtained dissolution product of (A′) and (B′) in (C′) at not more than 85° C.

(161) In the production method of the gel composition containing (A′), (B′) and (C′) oil agent, which further contains a step of dissolving, in (C′) oil agent, a dissolution product obtained by dissolving (A′) in (B′), generally, the amounts of (A′) and (B′) is 0.1-60 wt %, preferably 5-55 wt %, more preferably 10-50 wt %, further preferably 12-45 wt %, relative to the total weight of (A′), (B′) and (C′).

(162) The dissolution temperature is generally not more than 85° C., more preferably not more than 80° C. The lower limit is generally not less than 20° C., preferably not less than 35° C., more preferably not less than 40° C.

(163) The time necessary for dissolution is the time necessary for becoming uniform. It is generally 10-120 min, preferably 20-60 min, more preferably 30-40 min. Agitation is applied as necessary. When the mixture becomes uniform, it is cooled to give a gel composition. The definition and the like of each component are as described above.

(164) The above-mentioned production method may further include a step of adding (D′).

(165) Generally, (D′) is added to the gel composition at 0.1-70 wt %, preferably 2-50 wt %, more preferably 5-30 wt %, particularly preferably 12-25 wt %, based on the total weight of the gel composition containing (A′) (D′).

(166) As the timing of addition of (D′), it may be added to (C′) before or after dissolving (A′) and (B′). That is, the obtained composition prepared with (A′) and (B′) may be dissolved in a mixture of (C′) added with (D′), or (D′) may be added after dissolving the composition of (A′) and (B′) in (C′). It is preferable to dissolve in the mixture of (C′) added with (D′).

(167) The dissolution temperature is generally not more than 85° C., more preferably not more than 80° C., and the lower limit is generally not less than 20° C., preferably not less than 35° C., more preferably not less than 40° C.

(168) The time necessary for dissolution is the time necessary for becoming uniform. It is generally 10-120 min, preferably 20-60 min, more preferably 30-40 min. Agitation is applied as necessary. When the mixture becomes uniform, it is cooled to give a gel composition. The definition and the like of each component are as described above.

(169) The production method of the present invention may further contain a step of heating the gel composition at not more than 120° C. and removing (B′) from the gel composition. The heating temperature is generally not more than 120° C., preferably not more than 120° C., more preferably not more than 100° C., and the lower limit is not less than 80° C., from the aspects of removal rate of the solvent and stability of the starting materials. The heating can be performed by a method known per se.

(170) Removal of (B′) means reducing the content of (B′) in the gel composition or removing the total amount. It specifically means removing 10-99 wt %, preferably 50-95 wt %, more preferably 80-90 wt %, of the original content of (B′). The content of (B′) after removal in the gel composition is 0-5 wt %, preferably 0.01-1 wt %, more preferably 0.05-0.5 wt %.

(171) The time necessary for removal is generally 10-180 min, preferably 20-120 min, more preferably 30-60 min. Agitation is applied as necessary. When the mixture becomes uniform, it is cooled to give a gel composition.

(172) The step of removing (B′) may be performed after dissolving (C′) or after dissolving (C′) and (D′), and removal after dissolving (C′) and (D′) is preferable.

(173) Particularly, when the weight ratio of content (A′) to content (C′) {((A′)/(C′))×100} is generally 10 or below, preferably not more than 5, more preferably not more than 3, a gel composition with a high strength can be obtained by this step by using a smaller amount of (A′).

(174) The definition and the like of each component are as described above.

EXAMPLE

(175) While the present invention is explained in further detail by illustrating Examples, the present invention is not limited to the following Examples.

Experimental Example 1

(176) Mixtures (20 g) of (A′) and (B′) at proportions (wt %) shown in Table 1 were placed in glass vials, and mixed in an oil bath at a predetermined temperature until they were uniformly dissolved. When the mixture was not dissolved, the temperature was gradually raised with stirring until it was dissolved. The temperature of uniform mixing was measured by a thermometer, and the temperature at which (A′) was dissolved in (B′) was taken as a dissolution temperature.

(177) Evaluation of Dissolution Temperature

(178) A dissolution temperature of not more than 85° C. was evaluated as “(◯) preferable”, and a temperature exceeding 85° C. was evaluated as “(x) unpreferable”.

(179) Evaluation of Coloration

(180) Various components were placed in transparent glass vials, and mixed in an oil bath at a predetermined temperature until they were uniformly dissolved. White paper was put behind the container and the degree of solution coloration was confirmed by visual observation.

(181) When the solution was transparent or white, it was evaluated as “(◯) preferable”, and coloration to yellow or brown was evaluated as “(x) unpreferable”.

(182) When a component already having a color before heating was blended, coloration of the final blended product was not confirmed and it was rated as (−).

(183) As component (A′), an amino acid-based gelling agent “GP-1” manufactured by Ajinomoto Co., Inc. was used as dibutyl N-lauroyl-L-glutamide, an amino acid-based gelling agent “EB-21” manufactured by Ajinomoto Co., Inc. was used as dibutyl N-2-ethylhexanoyl glutamide (hereinafter the same), and prepared at GP-1:EB-21=3:2.

(184) The results are shown in Table 1A.

(185) TABLE-US-00022 TABLE 1A Formulation No. Comp. Comp. Comp. component Ex. 1-1 Ex. 1-2 Ex. 1-3 Ex. 1-1 Ex. 1-2 Ex. 1-3 Ex. 1-4 Ex. 1-5 Ex. 1-6 Ex. 1-7 B′ solvent used 2-octyl- oleyl pentylene ethanol ethanol ethanol ethanol ethanol isopropyl tert-butyl dodecanol glycol alcohol alcohol alcohol solvent (wt %) 80 80 80 80 60 50 45 43 60 70 A′ gelling agent (wt %) 20 20 20 20 40 50 55 57 40 30 total (wt %) 100 100 100 100 100 100 100 100 100 100 dissolution temperature (° C.) 120 85 110 55 65 72 78 80 75 75 evaluation of dissolution x x x ○ ○ ○ ○ ○ ○ ○ temperature redissolution temperature (° C.) 100 90 90 50 60 68 75 78 70 70 evaluation of coloration ○ ○ x ○ ○ ○ ○ ○ ○ ○

(186) As shown in Table 1A, it was confirmed that the dissolution temperature decreases by dissolving in a lower alcohol such as ethanol and the like.

Experimental Example 2

(187) Mixtures (20 g) of (A′) and (B′) at proportions shown in Table 2A were placed in glass vials, mixed in an oil bath at a predetermined temperature until they were uniformly dissolved, and evaluated by the same method as in Experimental Example 1. The temperature at which (A′) was dissolved in various solvents when the ratio of (A′) was changed and the results of coloration are shown in Table 2A.

(188) TABLE-US-00023 TABLE 2A formulation No. Comp. Comp. Comp. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. component 1-1-1 1-2-1 1-3-1 1-2-1 1-2-2 1-2-3 1-2-4 1-2-5 1-2-6 1-2-7 A′ EB-21:GP-1 3:1 3:1 3:1 3:1 2.5:1 2:1 1:1 4:1 7:1 11:1 A′ EB-21 30 30 30 30 28.6 26.7 20 28 26.25 22 A′ GP-1 10 10 10 10 11.4 13.3 20 7 3.75 2 B′ ethanol 60 60 60 60 65 70 76 B′ 2-octyldodecanol 60 — — — — — — — — — B′ pentyleneglycol — 60 — — — — — — — — B′ oleyl alcohol — — 60 — — — — — — — total 100 100 100 100 100 100 100 100 100 100 dissolution temperature (° C.) 140 105 135 80 78 75 70 80 80 75 evaluation of dissolution temperature x x x ○ ○ ○ ○ ○ ○ ○ evaluation of coloration ○ ○ x ○ ○ ○ ○ ○ ○ ○

(189) As shown in Table 2A, it was confirmed that the dissolution temperature decreases by dissolving any ratio of (A′) in ethanol.

Experimental Example 3

(190) At the proportions (wt %) shown in Table 2A, (A′)-(B′) were mixed and heated in advance to give uniform solutions. (C′)-(D′) at proportions (wt %) shown in Table 3 were placed in glass vials, and heated in an oil bath at a predetermined temperature. To the heated mixture was added a uniform mixture of A and B at the proportion shown in Table 3 and the mixture was mixed until it was uniformly dissolved. The amounts of the mixture of (A′) and (B′), and (C′), (D′) were measured and added such that the total amount of the mixture at the time of charging was 20 g. The dissolution temperature and coloration were evaluated by the same method as in Experimental Example 1.

(191) The uniformly dissolved solution was cooled at room temperature for not less than 3 hr to give a solid or gel mixture. The sample was evaluated as follows.

(192) Evaluation of Sweating

(193) A solid gel was stored in an apparatus, in which the temperature can be continuously changed in a cycle of from −5° C. to 40° C., for the time period of 3 cycles. Thereafter, the sample was taken out from the apparatus and stored in an environment of ordinary temperature and ordinary humidity for 12 hr. A droplet confirmed on the surface by visual observation was judged to mean presence of sweating of the gel composition and evaluated as “x” (unpreferable). A gel composition for which a droplet was hardly confirmed on the gel surface by visual observation even after a similar operation was judged to hardly have sweating, and evaluated as “(◯) (preferable)”. Furthermore, a gel composition for which a droplet was not confirmed on the gel surface by visual observation even after a similar operation was judged to have no sweating, and evaluated as “(⊙) very preferable”.

(194) The results are shown in Table 3A.

(195) Measurement of Breaking Strength of Gel

(196) The breaking strength of the gel was measured by FUDOH Rheometer D-series (manufactured by Rheotech Co., Ltd.). A gel composition with a flat surface set in the machine together with the container, and the measurement was performed using an adapter having a diameter of 10 mm under the conditions of an entrance speed of 6 cm/min and a load of 200 g. The breaking strength value was automatically calculated by the machine.

(197) A breaking strength value of less than 160 g/cm.sup.2 was judged to mean that a strong gel was formed and evaluated as “(◯) preferable”, not more than 100 g/cm.sup.2 and less than 160 g/cm.sup.2 was judged to mean that a gel with a certain strength was formed and evaluated as “(Δ) not very preferable”, and less than 100 g/cm.sup.2 was judged to be (x) unpreferable. In the Table, (−) means that evaluation was not performed.

(198) The results are shown in Table 3A.

(199) TABLE-US-00024 TABLE 3A-1 Example Example Example Example Example Example Example component component 2-1-1 2-2-1 2-3-1 2-4-1 2-4-2 2-5-1 2-6-1 C′ liquid paraffin 25 25 25 25 35 — C′ cetyl ethylhexanoate 40 — 40 — — C′ wheat germ oil — 40 — 40 40 91 96 D′ PEG-15 hydrogenated castor oil 20 20 — — — — isostearate (HLB 6) D′ polyglyceryl-10 dioleate (HLB 11) — — 20 20 20 5 A′ + B′ mixtureof Example 1-1 15 15 15 15 — — — A′ + B′ mixtureof Example 1-2 — — — — 5 — — A′ + B′ mixtureof Example 1-2-7 — — — — — 4 4 total (wt %) 100 100 100 100 100 100 100 evaluation of sweating ○ ○ ○ ○ ○ ⊙ ○ evaluation of coloration ○ — ○ — — — — qualitative evaluation of breaking ○ ○ ○ ○ ○ — — strength evaluation of dissolution temperature ○ ○ ○ ○ ○ ○ ○ breaking strength (g/cm.sup.2) of gel 161.13 216.62 165.79 193.65 223.3 — —

(200) TABLE-US-00025 TABLE 3A-2 Comp. Comp. Comp. Comp. Comp. Comp. Comp. Comp. Comp. Comp. Comp. Comp. Comp. compo- Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. nent component 2-1-1 2-1-2 2-1-3 2-2-1 2-2-2 2-2-3 2-3-1 2-3-2 2-3-3 2-4-1 2-4-2 2-4-3 2-5-1 C′ liquid paraffin 25 25 25 25 35 25 25 35 25 25 35 25 — C′ cetyl 40 40 40 — — — 40 40 40 — — — — ethyl- hexanoate C′ wheat germ — — — 40 40 40 — — — 40 40 40 90 oil D′ PEG-15 20 20 20 20 20 20 — — — — — — — hydrogenated castor oil isostearate (HLB 6) D′ polyglyceryl- — — — — — — 20 20 20 20 20 20 5 10 dioleate (HLB 11) A′ + B′ mixture of 15 — — 15 — — 15 — — 15 — — — Comparative Example 1-1 A′ + B′ mixture of — 5 — — 5 — — 5 — — 5 — — Comparative Example 1-3 A′ + B′ mixture of — — 15 — — 15 — — 15 — — 15 4 Comparative Example 1-2 total (wt %) 100 100 100 100 100 100 100 100 100 100 100 100 100 evaluation of ○ x ○ ○ x ○ ○ x ○ ○ x ○ x sweating evaluation of ○ ○ x — — — ○ ○ x — — — — coloration qualitative Δ x Δ Δ Δ Δ Δ x Δ Δ x Δ — evaluation of breaking strength evaluation of x ○ x x ○ x x ○ x x ○ x x dissolution temperature breaking 124.46 98.8 120.6 134.52 121.44 115.47 150.04 53.21 107.09 155.32 87.37 145.05 — strength (g/cm.sup.2) of gel

(201) As shown in Table 3A-1, it was confirmed that the compositions of the Examples were free of sweating phenomenon and superior in breaking strength.

Experimental Example 4

(202) Removal of Solvent and Evaluation of Removal Rate:

(203) At the proportions (wt %) shown in Table 4A, (A′)-(B′) were mixed and heated in advance to give uniform solutions. (C′) at proportions (wt %) shown in Table 4A was placed in glass vials, and heated in an oil bath at a predetermined temperature (115° C.). To the heated mixture was added a uniform mixture of A′ and B′ and the mixture was mixed until it was uniformly dissolved. The amounts of the mixture of (A′) and (B′), and (C′) were measured and added such that the total amount of the mixture at the time of charging was 20 g. To remove the solvent at the time of warming, the lid of the vial was opened and the mixture was heated for 40 minutes in the state of an open system. The difference in the total composition weight between before heating and after heating was calculated as the weight of the removed solvent, and the removal rate of the solvent was calculated from the following formula.
Removal rate (%) of solvent=(amount of solvent removed from formulation(composition)/amount of solvent added to formulation(composition))×100

(204) The mixture was cooled for not less than 3 hr at room temperature after removal of the solvent and the breaking strength of the solid or gel mixture was similarly measured as in Experimental Example 3.

(205) The results are shown in Table 4A.

(206) TABLE-US-00026 TABLE 4A formulation No. Comparative Comparative Comparative component Example 3-1 Example 3-2 Example 3-3 Example 3-1 C′ liquid paraffin (wt %) 90 90 90 96 B′ solvent used 2-octyldodecanol pentyleneglycol oleyl alcohol ethanol solvent (wt %) 8 8 8 2 A′ gelling agent (wt %) 2 2 2 2 wt % of gelling agent 2.22 2.22 2.22 2.08 necessary relative to oil (gelling agent/oil agent * 100) solvent removal rate <5% <5% <5% 90% breaking strength 77.11 0.87 66.32 190.9 (g/cm.sup.2) qualitative evaluation X X X ◯ of breaking strength

Experimental Example 5

(207) Removal of Solvent and Evaluation of Removal Rate:

(208) At the proportions (wt %) shown in Table 5A, (A′)-(B′) were mixed and heated in advance to give uniform solutions. (C′) at proportions (wt %) shown in Table 4A was placed in glass vials, and heated in an oil bath at a predetermined temperature (115° C.). To the heated mixture was added a uniform mixture of A′ and B′ and the mixture was mixed until it was uniformly dissolved. The amounts of the mixture of (A′) and (B′), and (C′) were measured and added such that the total amount of the mixture at the time of charging was 20 g. To remove the solvent at the time of warming, the lid of the vial was opened and the mixture was heated for 40 minutes in the state of an open system (Example 4-2). When the solvent was not removed, the mixture was heated with the lid of the vial closed (Example 4-1). The removal rate of the solvent was calculated in the same manner as in Experimental Example 4.
Removal rate (%) of solvent=(amount of solvent removed from formulation(composition)/amount of solvent added to formulation(composition))×100

(209) The mixture was cooled for not less than 3 hr at room temperature after removal of the solvent and the breaking strength of the solid or gel mixture was similarly measured as in Experimental Example 3.

(210) The results are shown in Table 5A.

(211) TABLE-US-00027 TABLE 5A formulation No. Example Example component 4-1 4-2 C′ wt % of oil agent (liquid 96 96 paraffin) B′ wt % of solvent (ethanol) 2 3 A′ the total amount of added 2 1 gelling agent wt % of gelling agent necessary 2.08 1.04 relative to oil (gelling agent/oil agent * 100) solvent removal rate <5% 90% breaking strength (g/cm.sup.2) 77.83 84

(212) Due to the removal of ethanol, formation of a gel having the same degree of strength was observed even when a smaller amount of a gelling agent was used.

(213) TABLE-US-00028 TABLE 6A Reference Formulation Example soft gel formulation for cleansing: component C′ wheat germ oil 27 component C′ cetyl ethylhexanoate 18 component C′ isopropyl myristate 11 component C′ tri(caprylic acid/capric acid)glyceryl 11 component C′ shea butter 11 component D′ polyglyceryl-10 dioleate 17 component D′ polyglyceryl-2 oleate 3 component B′ ethanol 1.2 component A′ dibutyl ethylhexanoyl glutamide (EB-21) 0.6 component A′ dibutyl lauroyl glutamide (GP-1) 0.2 total (wt %) 100

INDUSTRIAL APPLICABILITY

(214) Using the gel composition of the present invention, cosmetics perfumery, quasi-drug and the like can be produced easily without damaging the components to be blended in cosmetic and the like.

DESCRIPTION

(215) Title of the Invention: SOFT GEL COMPOSITION

TECHNICAL FIELD

(216) The present invention relates to a gelling agent containing N-acyl acidic amino acid dialkylamide and a gel composition containing the gelling agent.

BACKGROUND ART

(217) Low molecules of amino acid derivatives having three or more amide bonds such as dibutyl N-lauroyl-L-glutamide and dibutyl N-2-ethylhexanoyl glutamide are capable of gelling oils and is particularly known as a gelling agent superior in producing a solid gel with a high strength (breaking strength value not less than 200 g/cm.sup.2) by solidifying a liquid oil agent. For example, using these gelling agents, a gel composition having a high strength which can be molded into a stick shape or the like can be obtained (patent document 1″). In addition, by utilizing a mixture of these gelling agents, an emulsion composition can also be converted to a gel having a high strength, and an emulsion gel having a high strength which can be molded into a stick shape or the like can be obtained (patent document 2″).

(218) On the other hand, in the cosmetic field, a completely different application is considered for a soft solid gel having a low strength compared to a hard gel having a high strength. For example, a hard gel is necessary mainly for shape forming and shape stability, and cannot impart melting and softness of oil. If a liquid cosmetic composition can be turned into a soft gel, texture such as thickening and smoothness at the time of use of the formulation can be improved. Furthermore, in stick cosmetics such as lip and the like, it is known that a low strength of a gel composition is important for improving touch when in use (ability to be applied beautifully and evenly) (patent document 5″, Chapter 14). In addition, if a cosmetic generally used as liquid can be solidified into a soft gel, convenience in use such as stability of shape and ease of carrying can be improved without degrading the sense of use (patent document 4″).

(219) As a technique for obtaining a stick gel composition having a low strength, a technique is known in which a block copolymer with a high melting point is blended in an oil agent having a low melting point at a proportion of not less than 12% by weight, and a gelling agent of dibutylamide N-lauroyl-L-glutamate and dibutylamide N-2-ethylhexanoyl glutamate at a ratio of 3:1-1:1 is further blended in the composition. However, it is considered to be difficult to obtain a gel composition with smooth texture from a gel composition containing a large amount of a high molecular weight polymer. When a high molecular weight polymer is blended at a high concentration, moreover, problems occur in that superior texture cannot be achieved since spreadability of the gel composition on application is degraded and the like. In addition, since block copolymers have low solubility, it is necessary to add 20 wt % of a solvent in the formulation to dissolve the polymer (patent document 5″). On the other hand, when a soft gel composition is made from a low molecular gelling agent alone, a stability problem occurs in that the gel composition sweats (patent document 5″, Chapter 1). dibutyl N-2-ethylhexanoyl glutamide is used for a technique for producing a stable emulsion composition containing a large amount of water (patent document 3″). However, a gel composition having a shape cannot be produced using this technique, and the obtained composition was a liquid composition.

(220) In the case of a soft cream-like cosmetic, it is more conveniently used by filling in a container like a jar rather than a stick, and such jar type cosmetic is often used by taking with a finger. For the sense of use of a jar type product, therefore, it is very important that the cosmetic has moderate softness and can be easily taken with a finger. With the existing techniques, however, production of a stable and soft gel composition free of sweating which can be easily taken with a finger from a jar type container is considered to be difficult.

Document List

(221) Patent Documents

(222) patent document 1″: JP 4174994 B2 patent document 2″: U.S. Pat. No. 7,347,990 B2 patent document 3″: U.S. Pat. No. 8,591,871 B2 patent document 4″: WO 2016052072 A1 patent document 5″: U.S. Pat. No. 9,272,039 B2

SUMMARY OF THE INVENTION

Problems to be Solved by the Invention

(223) The present invention aims to provide a gelling agent and a gel composition, which are soft, stable, have a good sense of use, and are optimal for the production of cosmetics and the like.

Means of Solving the Problems

(224) In view of the above-mentioned problem, the present inventors have conducted intensive studies and found that a gel composition obtained by adding a gelling agent obtained by blending two or more kinds of N-acyl acidic amino acid dialkylamide at a particular ratio to an oil agent is a stable composition which is soft, does not leave solid gel particles when applied to the skin, turns into a smooth and thick liquid and shows extremely low sweating phenomenon, which resulted in the completion of the present invention.

(225) That is, the present invention includes the following embodiments.

(226) [1] A gelling agent comprising (A″) (A″-1) at least one kind of N-acyl acidic amino acid dialkylamide represented by the formula (I):

(227) ##STR00009##
wherein R.sup.1 and R.sup.2 are each independently a straight chain or branched chain alkyl group having 1-7 carbon atoms, R.sup.3 is a straight chain alkyl group having 3-15 carbon atoms, and n is 1 or 2, and
(A″-2) at least one kind of N-acyl acidic amino acid dialkylamide represented by the formula (II):

(228) ##STR00010##
wherein R.sup.1 and R.sup.2 are each independently a straight chain or branched chain alkyl group having 1-7 carbon atoms, R.sup.4 is a branched chain alkyl group having 3-15 carbon atoms, and n is 1 or 2, at a weight ratio (A″-1):(A″-2) of 1:1.5-1:1000.
[1-1] The gelling agent of [1], wherein R.sup.3 is a straight chain alkyl group having 7-11 carbon atoms and R.sup.4 is a branched chain alkyl group having 7-11 carbon atoms.
[2] The gelling agent of [1], wherein (A″-1) is dibutyl N-lauroyl glutamide.
[3] The gelling agent of [1] or [2], wherein (A″-2) is dibutyl N-2-ethylhexanoyl glutamide.
[4] The gelling agent of any one of [1] to [3], further comprising (B″) at least one kind of solvent selected from the group consisting of alcohol, polyol, organic acid, organic amine, ether compound and silicone compound.
[4-1] The gelling agent of any one of [1] to [3], wherein (B″) comprises at least one kind of solvent selected from the group consisting of ethanol, 2-octyldodecanol, oleyl alcohol, pentyleneglycol and myristic acid.
[4-2] The gelling agent of any one of [1] to [3], wherein (B″) comprises at least one kind of solvent selected from the group consisting of ethanol, pentyleneglycol, dipropyleneglycol and 1,3-butyleneglycol.
[5] A gel composition comprising the gelling agent of any one of [1] to [4], and (C″) an oil agent.
[6] The gel composition of [5], wherein (C″) is at least one kind selected from the group consisting of an oil agent for cosmetics and an oil agent for pharmaceutical products.
[6-1] The gel composition of [5], wherein (C″) is at least one kind selected from the group consisting of jojoba seed oil, wheat germ oil, isopropyl myristate, cetyl ethylhexanoate and tri(caprylic acid/capric acid)glyceryl.
[7] The gel composition of [5] or [6], wherein the total amount of the gelling agent of any one of [1] to [4] is 0.1-50 wt % relative to the total weight of the gel composition.
[8] The gel composition of any one of [5] to [7], further comprising (D″) an emulsifier.
[8-1] The gel composition of [8], wherein (D″) is an emulsifier with HLB 12-16.
[8-2] The gel composition of [8], wherein (D″) is at least one selected from the group consisting of polyglyceryl-10 dioleate, polyglyceryl-10 cocoate, polyglyceryl-3 cocoate, PEG-40 glyceryl triisostearate and PEG-40 glyceryl isostearate.
[8-3] The gel composition of any one of [5] to [8-2], wherein the gel has a breaking strength of 15-150 g/cm.sup.2.
[9] The gel composition of any one of [5] to [8-3], wherein the composition is a cosmetic, a perfumery or a quasi-drug composition.
[10] A cosmetic comprising the gel composition of any one of
[5] to [8-3].

Effect of the Invention

(229) According to the present invention, a gel that turns into a soft, smooth liquid free of particles when applied can be provided.

(230) According to the present invention, a stable gel with extremely less sweating phenomenon even at a high temperature or a low temperature can be provided.

Description of Embodiments

(231) The present invention relates to a gelling agent containing (A″) (A″-1) at least one kind of N-acyl acidic amino acid dialkylamide represented by the formula (I):

(232) ##STR00011##
wherein R.sup.1 and R.sup.2 are each independently a straight chain or branched chain alkyl group having 1-7 carbon atoms, R.sup.3 is a straight chain alkyl group having 3-15 carbon atoms, and n is 1 or 2, and
(A″-2) at least one kind of N-acyl acidic amino acid dialkylamide represented by the formula (II):

(233) ##STR00012##
wherein R.sup.1 and R.sup.2 are each independently a straight chain or branched chain alkyl group having 1-7 carbon atoms, R.sup.4 is a branched chain alkyl group having 3-15 carbon atoms, and n is 1 or 2, at a weight ratio (A″-1):(A″-2) of 1:1.5-1000.
(A″) N-Acyl Acidic Amino Acid Dialkylamide

(234) In the formula, R.sup.1 and R.sup.2 are each independently a straight chain or branched chain alkyl group having 1-7 carbon atoms. Examples of the straight chain or branched chain alkyl group having 1-7 carbon atoms include methyl group, ethyl group, isopropyl group, propyl group, butyl group, isobutyl group, sec-butyl group, tert-butyl group, pentyl group, sec-pentyl group, tert-pentyl group, isopentyl group, hexyl group, and heptyl group and the like. Since an effective gel strength can be exhibited with a small amount, a straight chain or branched chain alkyl group having 3-5 carbon atoms is preferable, and a butyl group is more preferable. It is more preferable that both R.sup.1 and R.sup.2 be straight chain or branched chain alkyl groups having 3-5 carbon atoms, and it is further preferable that both R.sup.1 and R.sup.2 be butyl groups.

(235) In the formula, R.sup.3 is a straight chain alkyl group having 3-15 carbon atoms.

(236) Examples of the straight chain alkyl group having 3-15 carbon atoms include a propyl group, a butyl group, a pentyl group, a hexyl group, a heptyl group, an octyl group, a nonyl group, a decyl group, an undecyl group, a dodecyl group, a tridecyl group, a tetradecyl group, and a pentadecyl group and the like. Since an effective gel strength can be exhibited with a small amount, a straight chain alkyl group having 5-13 carbon atoms is preferable, a straight chain alkyl group having 7-11 carbon atoms is more preferable, and an undecyl group is most preferable.

(237) In the formula, R.sup.4 is a branched chain alkyl group having 3-15 carbon atoms.

(238) Examples of the branched chain alkyl group having 3-15 carbon atoms include an isopropyl group, an isobutyl group, a sec-butyl group, a tert-butyl group, a sec-pentyl group, a tert-pentyl group, an isopentyl group, a 1-ethylpentyl group, an octyl group, a 2-ethylhexyl group, a tert-octyl group, an isononyl group, an isodecyl group, an isotridecyl group and the like. From the aspect that an effective gel strength can be exhibited with a small amount, preferred is a branched chain alkyl group having 5-13 carbon atoms, more preferred is a branched chain alkyl group having 7-11 carbon atoms, and most preferred is a 1-ethylpentyl group.

(239) n is 1 or 2. When n is 1, (A″) is N-acyl aspartic acid dialkylamide, and when n is 2, (A″) is N-acyl glutamic acid dialkylamide. Since an effective gel strength can be exhibited with a small amount, n is preferably 2 (N-acylglutamic acid dialkylamide).

(240) Specific examples of the N-acyl acidic amino acid dialkylamide (A″-1) include diisopropyl N-hexanoyl glutamide, dibutyl N-hexanoyl glutamide, di-sec-butyl N-hexanoyl glutamide, diisobutyl N-hexanoyl glutamide, diisopropyl N-octanoyl glutamide, dibutyl N-octanoyl glutamide, di-sec-butyl N-octanoyl glutamide, diisobutyl N-octanoyl glutamide, diisopropyl N-decanoyl glutamide, dibutyl N-decanoyl glutamide, di-sec-butyl N-decanoyl glutamide, diisobutyl N-decanoyl glutamide, dimethyl N-lauroyl glutamide, diethyl N-lauroyl glutamide, dipropyl N-lauroyl glutamide, diisopropyl N-lauroyl glutamide, dibutyl N-lauroyl glutamide, di-sec-butyl N-lauroyl glutamide, diisobutyl N-lauroyl glutamide, dipentyl N-lauroyl glutamide, dihexyl N-lauroyl glutamide, diisopropyl N-palmitoyl glutamide, dibutyl N-palmitoyl glutamide, di-sec-butyl N-palmitoyl glutamide, diisobutyl N-palmitoyl glutamide, diisopropyl N-myristoyl glutamide, dibutyl N-myristoyl glutamide, di-sec-butyl N-myristoyl glutamide, diisobutyl N-myristoyl glutamide, diisopropyl N-lauroyl aspartamide, dibutyl N-lauroyl aspartamide, di-sec-butyl N-lauroyl aspartamide, and diisobutyl N-lauroyl aspartamide, preferably, diisopropyl N-lauroyl glutamide, dibutyl N-lauroyl glutamide, di-sec-butyl N-lauroyl glutamide and diisobutyl N-lauroyl glutamide. More preferred is dibutyl N-lauroyl glutamide.

(241) Specific examples of N-acyl acidic amino acid dialkylamide (A″-2) include dimethyl N-2-ethylhexanoyl glutamide, diethyl N-2-ethylhexanoyl glutamide, dipropyl N-2-ethylhexanoyl glutamide, diisopropyl N-2-ethylhexanoyl glutamide, dibutyl N-2-ethylhexanoyl glutamide, di-sec-butyl N-2-ethylhexanoyl glutamide, diisobutyl N-2-ethylhexanoyl glutamide, dipentyl N-2-ethylhexanoyl glutamide, dihexyl N-2-ethylhexanoyl glutamide, diisopropyl N-2-ethylhexanoyl aspartamide, dibutyl N-2-ethylhexanoyl aspartamide, di-sec-butyl N-2-ethylhexanoyl aspartamide, diisobutyl N-2-ethylhexanoyl aspartamide. Preferred are diisopropyl N-2-ethylhexanoyl glutamide, dibutyl N-2-ethylhexanoyl glutamide, di-sec-butyl N-2-ethylhexanoyl glutamide and diisobutyl N-2-ethylhexanoyl glutamide, and more preferred is dibutyl N-2-ethylhexanoyl glutamide.

(242) As (A″), one or more kinds of (A″-1) and one or more kinds of (A″-2) from those mentioned above can be used in combination.

(243) When (A″-1) dibutyl N-lauroyl glutamide (hereinafter sometimes to be abbreviated as GP-1) and (A″-2) dibutyl N-2-ethylhexanoyl glutamide (hereinafter sometimes to be abbreviated as EB-21) are used, the weight ratio (A″-1):(A″-2) is generally 1:1.5-1:1000, preferably 1:2-1:500, more preferably 1:2.5-1:100, from the aspect of the stability of the gel composition.

(244) The N-acyl acidic amino acid dialkylamide represented by the formula (I) may be a stereoisomer such as optical isomer, diastereomer and the like, a mixture of any stereoisomers, or racemate.

(245) (B″) Solvent

(246) The gelling agent of the present invention may further contain (B″) a solvent. (B″) is not particularly limited as long as it can dissolve (A″-1) and (A″-2), and those generally used for cosmetics, pharmaceutical products and the like can be mentioned. For example, alcohol, polyol(polyhydric alcohol), organic acid, organic amine, ether compound, silicone compound and the like can be mentioned.

(247) Examples of the alcohol include lower alcohols such as isopropyl alcohol, t-butyl alcohol and ethanol, and higher alcohols such as 2-octyldodecanol, 2-hexyldecyl alcohol, lauroyl alcohol, isostearyl alcohol, 2-ethylhexanol, isononyl alcohol and oleyl alcohol. As lower alcohol, isopropyl alcohol, t-butyl alcohol and ethanol are preferable, and as higher alcohol, 2-hexyldecyl alcohol, lauroyl alcohol, oleyl alcohol and the like are preferable.

(248) Examples of polyol(polyhydric alcohol) include pentyleneglycol, dipropyleneglycol, butyleneglycol (1,3-butanediol), propylene glycol (1,2-propanediol), 1,4-butanediol, 1,3-propanediol and the like, and polyols such as pentyleneglycol, dipropyleneglycol, 1,4-butanediol and the like are preferable.

(249) In another embodiment, as polyol(polyhydric alcohol), polyols such as pentylene glycol, dipropylene glycol, 1,3-butylene glycol (1,3-butanediol), propylene glycol (1,2-propanediol), 1,4-butanediol, 1,3-propanediol and the like, and pentylene glycol, dipropylene glycol, 1,3-butanediol and the like are preferable.

(250) Examples of the organic acid include lactic acid, capric acid, lauric acid, myristic acid, stearic acid, 12-hydroxystearic acid, ricinoleic acid, isostearic acid, 2-ethylhexanoic acid, isononanoic acid and the like, and lactic acid, capric acid, lauric acid, myristic acid, stearic acid, 12-hydroxystearic acid, ricinoleic acid, isostearic acid and the like are preferable. Among these, myristic acid and isostearic acid are more preferable.

(251) Examples of the organic amine include monomethylamine hydrochloride, triethanolamine, lauryl dimethylamine N-oxide, oleyl dimethylamine N-oxide and the like, and organic amine such as triethanolamine and the like, and the like are preferable.

(252) Examples of the ether compound include dimethylisosorbide, alkyl(C12-15) benzoate and the like, and alkyl(C12-15) benzoate and the like are preferable.

(253) Examples of the silicone compound include cyclopentasiloxane, cyclohexasiloxane, amodimethicone and the like, and cyclohexasiloxane, amodimethicone and the like are preferable.

(254) Among (B″), isopropyl alcohol, ethanol, oleyl alcohol, pentylene glycol, dipropylene glycol, 1,4-butanediol, lactic acid, capric acid, myristic acid, 12-hydroxystearic acid, isostearic acid, alkyl(C12-15) benzoate and cyclohexasiloxane are more preferable.

(255) In another embodiment, among (B″), ethanol, 2-octyldodecanol, oleyl alcohol, pentylene glycol, dipropylene glycol, 1,3-butylene glycol and myristic acid are preferable, ethanol, pentylene glycol, dipropylene glycol and 1,3-butylene glycol are more preferable, and pentylene glycol, dipropylene glycol and 1,3-butylene glycol are more preferable.

(256) The content of (B″) in the gelling agent of the present invention is generally 0.5-9.5 parts by weight, preferably 0.6-9 parts by weight, more preferably 0.8-5 parts by weight, relative to the 1 part by total weight of (A″-1) and (A″-2) from the aspect that the uniform dissolution temperature of the formulation becomes low.

(257) The shape of the gelling agent of the present invention is not particularly limited, and is, for example, liquid, gel, particle, solid, stick, sphere, sheet or the like. Of these, gel, solid, sphere and sheet are preferable.

(258) (C″) Oil Agent

(259) A gel composition which is another embodiment of the present invention contains the above-mentioned gelling agent and (C″) and can be generally obtained by dissolving the gelling agent in (C″).

(260) (C′) in the present invention can be used without particularly restriction as long as it is an oil agent used for cosmetic, pharmaceutical products and the like. Examples thereof include liquid oil agent, semisolid oil agent, solid oil agent and the like, with preference given to a liquid oil agent.

(261) Specifically, liquid oil agent such as straight chain or branched hydrocarbon oil such as liquid paraffin, light isoparaffin, liquid isoparaffin, squalane, squalene and the like; vegetable oils such as shea butter, almond oil, jojoba oil, olive oil, jojoba seed oil, maize germ oil, wheat germ oil, meadowfoam oil, sunflower oil, and the like; animal-derived fats and oils such as liquid lanolin and the like; ester oils such as fatty acid ester, polyhydric alcohol fatty acid ester (e.g., isopropyl myristate, cetyl ethylhexanoate, ethylhexyl palmitate, cetyl palmitate, isopropyl palmitate, tri(caprylic acid/capric acid)glyceryl, triethylhexanoin and the like);

(262) acylamino acid esters such as isopropyl lauroyl sarcosine (Eldew (registered trade mark) SL-205), N-lauroyl-L-glutamic acid di(cholesteryl/octyldodecyl), hexyldecyl myristoyl methyl aminopropionate, dihexyldecyl lauroyl glutamate, diisostearyl lauroyl glutamate, dioctyldodecyl lauroyl glutamate, lauroyl glutamic acid bis(hexyldecyl/octyldodecyl), dioctyldodecyl lauroyl glutamate, dioctyldodecyl stearoyl glutamate and the like; phytosterol esters such as N-lauroyl-L-glutamic acid di(phytosteryl/2-octyldodecyl) and the like; silicone oil such as cyclopentasiloxane, dimethylpolysiloxane, dimethylcyclopolysiloxane, methylphenylpolysiloxane, methyl hydrogen polysiloxane, higher alcohol denatured organopolysiloxane, and the like, silicone oil of fluorine oil such as fluoropolyether, perfluoro alkylethersilicone and the like, and the like;

(263) Semisolid oil agent such as cholesteryl esters such as cholestryl isostearate, cholestryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, N-lauroyl-L-glutamic acid di(cholesteryl/behenyl/octyldodecyl) and the like; phytosterol esters such as N-lauroyl-L-glutamic acid di(phytosteryl/behenyl/2-octyldodecyl), myristoylmethyl-β-alanine(phytosteryl/decyltetradecyl)isostearic acid phytosteryl, phytosteryl oleate and the like; dipentaerythrityl fatty acid esters such as dipentaerythrityl hexaoxystearate, dipentaerythrityl rosinate and the like; triglycerides such as tri(caprylic acid/capric acid)glyceryl, tri(capuryl/capric/myristic/stearic acid) glycerides and the like; partially hydrogenated triglycerides such as hydrogenated oil and the like; lanolin, lanosterols, petrolatum and the like;
solid oil agents such as animal-derived wax, plant-derived wax, mineral wax, synthetic wax, specifically, rice bran wax, carnauba wax, candelilla wax, beeswax, spermaceti, ceresin, solid paraffin, microcrystalline wax, polyethylene wax, polyolefinwax and the like.

(264) Among these, from the aspect of broad utility, hydrocarbon oil such as solid paraffin, liquid paraffin and the like, fatty acid ester oil such as cetyl ethylhexanoate, ethylhexyl palmitate, isopropyl myristate, isopropyl palmitate, tri(caprylic acid/capric acid)glyceryl, triethylhexanoin and the like, vegetable oil such as shea butter, almond oil, wheat germ oil, jojoba seed oil, olive oil, meadowfoam oil and the like, phytosterol esters such as N-lauroyl-L-glutamic acid di(phytosteryl/2-octyldodecyl) and the like, acylamino acid ester oil such as isopropyl lauroylsarcosine and the like, and the like are preferable.

(265) In another embodiment, from the aspect of broad utility, hydrocarbon oils such as petrolatum, solid paraffin, liquid paraffin, and the like; silicone oil such as cyclopentasiloxane and the like; fatty acid ester oils such as cetyl ethylhexanoate, ethylhexyl palmitate, isopropyl myristate, isopropyl palmitate, tri(caprylic acid/capric acid)glyceryl, triethylhexanoin and the like; vegetable oils such as shea butter, almond oil, wheat germ oil, jojoba seed oil, olive oil, meadowfoam oil and the like; phytosterol esters such as N-lauroyl-L-glutamic acid di(phytosteryl/2-octyldodecyl) and the like, acylamino acid ester oil such as isopropyl lauroylsarcosine and the like, and the like are preferable, and jojoba seed oil, wheat germ oil, isopropyl myristate, cetyl ethylhexanoate and tri(caprylic acid/capric acid)glyceryl are more preferable.

(266) The gel composition obtained by dissolving the gelling agent of the present invention in (C″) generally contains a gelling agent 0.1-50 wt % and (C″) 5-99.9 wt %, preferably 0.1-20 wt % and (C″) 5-99.9 wt %, more preferably a gelling agent 0.5-15 wt % and (C″) 15-99.5 wt %, further preferably a gelling agent 1-10 wt % and (C″) 30-99.2 wt %, relative to the total weight of the gel composition, from the aspects of formation of a soft gel composition and improvement of the stability of the composition.

(267) More specifically, from the aspects of formation of a soft gel composition, easy taking (easy scooping) when in use and improvement of stability of the composition, a composition containing (A″), (B″) and (C″) contains (A″) 0.1-10 wt %, (B″) 0-40 wt % and (C″) 10-99.8 wt %, preferably (A″) 0.2-5 wt %, (B″) 0.2-25 wt % and (C″) 20-98 wt %, more preferably (A″) 0.5-3 wt %, (B″) 0.5-20 wt % and (C″) 30-95 wt %, relative to the total weight of the composition.

(268) The breaking strength of the gel in the gel composition of the present invention is generally not more than 200 g/cm.sup.2, preferably 15-150 g/cm.sup.2, more preferably 15-70 g/cm.sup.2. Here, the breaking strength of the gel is a value indicating the numerical value in g per unit square centimeter, which is the force required to break the gel, and can be measured using a gel compression-recovery measuring instrument such as FUDOH Rheometer D-series (manufactured by Rheotech Co., Ltd.).

(269) (D″) Emulsifier

(270) The emulsifier in the present invention is not particularly limited as long as it is used for cosmetics, pharmaceutical products and the like, and nonionic emulsifiers can be mentioned.

(271) Among the nonionic emulsifiers, emulsifiers generally having HLB 5-17 are generally used from the aspect of compatibility with oil. Particularly, an emulsifier having HLB 8-17 is preferable, and an emulsifier having HLB 10-16 is more preferable, from the aspects of reduction of sweating of the formulation and improvement of stability.

(272) Examples of the emulsifier having HLB 5-8 include polyglyceryl-2 oleate, polyglyceryl-2 sesquicaprylate, PEG-20 glyceryl triisostearate, PEG-50 hydrogenated (hydrogenated) castor oil isostearate and the like, and polyglyceryl-2 oleate, PEG-50 hydrogenated castor oil isostearate are preferable.

(273) Examples of the emulsifier having HLB 10-16 include PEG-8 glyceryl isostearate, polyglyceryl-10 cocoate, polyglyceryl-3 cocoate, PEG-7 glyceryl cocoate, polyglyceryl-10 dioleate, polyglyceryl-10 diisostearate, PEG-40 glyceryl triisostearate, PEG-40 glyceryl isostearate, polyglyceryl-10 trilaurate, hexaglyceryl tricaprylate and the like.

(274) Among these, polyglyceryl-10 dioleate, PEG-8 glyceryl isostearate, polyglyceryl-10 cocoate, polyglyceryl-3 cocoate, PEG-40 glyceryl triisostearate, PEG-40 glyceryl isostearate and the like are preferably used.

(275) In another embodiment, among the nonionic emulsifiers, nonionic emulsifiers generally having HLB 5-16 or HLB 5-17 are used from the aspect of compatibility with oil. Among those, from the aspect of less sweating of formulation and improved stability, emulsifiers having HLB 8-17 are preferable, emulsifiers having HLB 8-16 are more preferable, emulsifiers having HLB 10-16, and emulsifiers having HLB 12-16 are particularly preferable. It is also possible to use a mixture of a nonionic surfactant having a low HLB and a surfactant having a high HLB.

(276) Examples of the emulsifier with HLB 10-16 include sorbeth-60 tetraoleate (tetraoleic acid polyoxyethylene(60)sorbit), PEG(polyethylene glycol)-8 glyceryl isostearate, PEG(polyethylene glycol)-7 glyceryl cocoate, polyglyceryl-10 dioleate, polyglyceryl-10 diisostearate, polyglyceryl-10 trilaurate, hexaglyceryl tricaprylate, polyglyceryl-10 cocoate, polyglyceryl-3 cocoate, PEG(polyethylene glycol)-40 glyceryl triisostearate, PEG(polyethylene glycol)-40 glyceryl isostearate, PEG(polyethylene glycol)-50 hydrogenated castor oil isostearate, polysorbate 60, sorbeth-30 tetraoleate, glyceryl stearate (SE: self-emulsifying type). Examples of the emulsifier with HLB 17 include PEG(polyethylene glycol)-100 stearate.

(277) Examples of the emulsifier with HLB 5—less than 10 include polyglyceryl-2 stearate, polyglyceryl-2 oleate, polyglyceryl-2 sesquicaprylate, PEG(polyethylene glycol)-20 glyceryl triisostearate, PEG(polyethylene glycol)-15 hydrogenated castor oil isostearate, PEG(polyethylene glycol)-6 sorbitan oleate.

(278) Among these, polyglyceryl-10 dioleate, PEG-8 glyceryl isostearate, polyglyceryl-10 cocoate, polyglyceryl-3 cocoate, PEG-40 glyceryl triisostearate, PEG-40 glyceryl isostearate, PEG-50 hydrogenated castor oil isostearate, polyglyceryl-2 oleate, PEG-15 hydrogenated castor oil isostearate, polysorbate 60, sorbeth-30 tetraoleate, glyceryl stearate (SE: self-emulsifying type) are preferable, polyglyceryl-10 dioleate, polyglyceryl-10 cocoate, polyglyceryl-3 cocoate, PEG-40 glyceryl triisostearate, PEG-40 glyceryl isostearate, PEG-50 hydrogenated castor oil isostearate, polyglyceryl-2 oleate, polysorbate 60, sorbeth-30 tetraoleate, glyceryl stearate (SE: self-emulsifying type) are more preferable, polyglyceryl-10 dioleate, polyglyceryl-10 cocoate, polyglyceryl-3 cocoate, PEG-40 glyceryl triisostearate, PEG-40 glyceryl isostearate are further preferable, and polyglyceryl-10 dioleate, polyglyceryl-10 cocoate, polyglyceryl-3 cocoate are particularly preferable.

(279) The contents of the gelling agent of the present invention and (C″) and (D″) are generally gelling agent 0.1-50 wt %, (C″) 5-99.8 wt % and (D″) 0.1-80 wt %, preferably gelling agent 0.1-20 wt %, (C″) 5-99.8 wt % and (D″) 0.1-80 wt %, more preferably gelling agent 0.5-15 wt %, (C″) 15-98.5 wt % and (D″) 1-50 wt %, further preferably gelling agent 1-10 wt %, (C″) 30-95 wt % and (D″) 3-20 wt %, relative to the total weight of the gel composition, from the aspects of formation of a soft gel composition, easiness of taking when in use, sensory evaluation on application and improvement of stability of the formulation without stimulation.

(280) More particularly, from the aspects of formation of a soft gel composition, easiness of taking when in use, sensory evaluation on application and improvement of stability of the formulation, a composition containing (A″), (B″), (C″) and (D″) generally contains (A″) 0.1-10 wt %, (B″) 0-40 wt %, (C″) 10-99.7 wt % and (D″) 0.1-80 wt %, preferably (A″) 0.2-5 wt %, (B″) 0.2-25 wt %, (C″) 30-95 wt % and (D″) 1-50 wt %, more preferably (A″) 0.5-3 wt %, (B″) 0.5-20 wt %, (C″) 40-90 wt % and (D″) 3-20 wt %, each relative to the total weight of the composition.

(281) In the present invention, as preferable proportions of (A″) and (D″), a composition containing not less than 0.5 wt % and not more than 2 wt % of (A″) in which (A″-1):(A″-2) is 1:4-1:20, and about 3 wt % of (D″) an emulsifier having HLB 10-17 can be mentioned.

(282) While the form (shape) of the gel composition of the present invention is not particularly limited, it is, for example, gel, particle, solid, stick, sphere, sheet or the like. Among these, gel, solid, sphere or sheet is preferable.

(283) While the production method of the gelling agent of the present invention is not particularly limited, for example, the object gelling agent can be obtained by stirring a mixture of (A″) and (B″) with heating until a uniform solution is formed, and thereafter cooling same as necessary. While the heating temperature varies depending on the kind and contents of (A″) and (B″), it can be obtained by, for example, mixing-heating the mixture at 85-130° C. for 5-30 min in an oil bath or by a heater and leaving the mixture at room temperature.

(284) The redissolution temperature (melting point) of the gel composition of the present invention is generally not more than 150° C., preferably not more than 130° C., more preferably not more than 110° C.

(285) While the production method of the gel composition of the present invention is not particularly limited, the object gel composition can be obtained by, for example, mixing (A″), or a mixture of (A″) and (B″) with (C″), stirring the mixture with heating until a uniform solution is formed, and cooling the mixture as necessary. In addition, the object gel composition can be obtained by, for example, mixing (A″), or a mixture of (A″) and (B″) with a mixture containing (C″) and (D″), stirring the mixture with heating until a uniform solution is formed, and cooling the mixture as necessary. While the heating temperature varies depending on the kind and contents of (A″)-(D″), the gel composition can be obtained by, for example, mixing-heating the mixture in an oil bath or by using a heater at 85-130° C. for 5-30 min, and leaving the mixture at room temperature.

(286) The dissolution temperature (melting point) of the gel composition of the present invention is generally not more than 150° C., preferably not more than 130° C., more preferably not more than 110° C.

(287) In addition, the gel composition of the present invention can also contain components generally usable for cosmetics such as a gelling agent other than (A′) of the present invention, humectant, flavor, various chelating agents, antiperspirant active ingredient, surfactants, various additives, various powders, and the like within the range where the effect of the present invention is not inhibited.

(288) Examples of the moisturizer include glycerol, urea, PCA-Na (sodium pyrrolidonecarboxylate), hyaluronic acid, amino acid mixture, heparosan, ceramide and the like.

(289) Examples of the flavor include linalool, limonene, menthol, peppermint oil, vanillin and the like.

(290) While various chelating agents are not particularly limited, preferable examples include a chelator selected from the group consisting of triethylenetetramine, 2-thenoyltrifluoroacetone, thioglycolic acid, tartaric acid, succinic acid, 8-quinolinol, pyridine-2,6-dicarboxylic acid, pyridine, 1,10-phenanthroline, lactic acid, 8-hydroxyquinoline-5-sulfonic acid, glycine, 2,2′-pyridylethylenediamine, aurintricarboxylic acid, xylenol orange, 5-sulfosalicyl acid, salicylic acid, pyrocatechol-3,5-disulfonate, 4,5-dihydroxybenzene-1,3-disulfonic acid, 1,2-diaminocyclohexane-N,N,N′,N′-tetraacetic acid, citric acid, oxalate, nitrilotriacetic acid, ethylenediamine-N,N,N′,N′-tetraacetic acid, acetylacetone, and salts thereof and a mixture thereof and the like.

(291) Examples of the antiperspirant active ingredient include one kind selected from the group consisting of aluminum chlorohydrate, aluminum chloride, aluminum chlorohydrate allantoinate, aluminum sulfate, zinc oxide, zinc para-phenolsulfonate, and zirconium aluminum complex produced by reacting zirconylchloride with aluminum hydroxide and aluminumchlorohydroxide, and a mixture thereof. As used herein, the antiperspirant active ingredient refers to a component that suppresses sweating by causing strong adstriction of the skin.

(292) Examples of the surfactant other than nonionic emulsifier include anionic surfactant such as N-long chain acylamino acid salts such as N-long chain acylglutamate, N-long chain acylglycine salt, N-long chain acylalanine salt, N-long chain acyl N-methyl-β-alanine salt and the like, N-long chain fatty acid acyl-N-methyltaurine salt, alkylsulfate and alkyleneoxide adduct thereof, fatty acid amide ether sulfate, metal salt or weak base salt of fatty acid, sulfosuccinic acid-based surfactant, alkyl phosphate and alkyleneoxide adduct thereof, alkylethercarboxylic acid, and the like; non-ionic surfactants such as ether type surfactants such as glycerolether and alkyleneoxide adduct thereof and the like, ether ester type surfactants such as alkylene oxide adduct of glycerolester, alkylene oxide adduct of sorbitan ester, polyoxyalkylene fatty acid ester and the like, ester type surfactants such as glycerol fatty acid ester, fatty acid polyglycerolester, sorbitan fatty acid ester, sucrose fatty acid ester and the like, alkylglucosides such as (caprylyl/capuryl)glucoside and the like, hydrogenated castor oil pyroglutamic acid diester and ethylene oxide adduct thereof, nitrogen-containing type non-ionic surfactants such as fatty acid alkanolamide and the like, and the like; cationic surfactant such as aliphatic amine salt (alkyl ammonium chloride, dialkyl ammonium chloride and the like), aromatic quaternary ammonium salt (quaternary ammonium salt thereof, benzalkonium salt thereof and the like), fatty acid acyl arginine ester, and the like; and amphoteric surfactant such as betaine type surfactant (carboxybetaine and the like), aminocarboxylic acid type surfactant, imidazoline type surfactant and the like, and the like.

(293) Examples of the various additives include amino acids such as glycine, alanine, serine, threonine, arginine, glutamic acid, aspartic acid, isoleucine, leucine, valine and the like; water-soluble polymer such as polyamino acid including polyglutamic acid and polyaspartic acid and a salt thereof, gum arabics, alginates, xanthan gum, chitin, chitosan, water-soluble chitin, carboxyvinyl polymer, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropyltrimethylammonium chloride, polychlorodimethylmethylenepiperidium, polyvinylpyrrolidone derivative, quartenary ammonium cationized protein, collagen decomposed product and a derivative thereof, acylated protein and the like; sugar alcohol such as mannitol and the like and alkylene oxide adduct thereof; animals and plants extract, nucleic acid, vitamin, enzyme, anti-inflammatory agent, antimicrobial agent, preservative, antioxidant, ultraviolet absorber, adiaphoretic, pigment, dye, oxidation dye, pH adjuster, pearly agent, wetting agent and the like, and the like.

(294) Examples of the various powders include resin powder such as nylon beads, silicone beads and the like, nylon powder, metal fatty acid soap, yellow iron oxide, red iron oxide, black iron oxide, chrome oxide, cobalt oxide, carbon black, ultramarine blue, iron blue, zinc oxide, titanium oxide, zirconium oxide, silicon oxide, aluminum oxide, cerium oxide, micatitanium, boron nitride, barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate, magnesium silicate, silicon carbide, dye, lake, sericite, mica, talc, kaolin, plate-shaped barium sulfate, butterfly-shaped barium sulfate, titanium oxide fine particles, zinc oxide fine particles, iron oxide fine particles, acylamino acid such as acyllysine, acylglutamic acid, acylarginine, acylglycine and the like, and the like can be mentioned, which may be further subjected to a surface treatment such as silicone treatment, fluorine compound treatment, silane coupling agent treatment, silane treatment organic titanate treatment, acylation lysine treatment, fatty acid treatment, metal soap treatment, oil treatment, amino acid treatment and the like.

(295) The gel composition of the present invention can be used as it is or as cosmetic, perfumery or quasi-drug after blending the aforementioned components.

(296) The gel composition of the present invention can be used as a base of cosmetic, perfumery, pharmaceutical product, quasi-drug and the like, a texture modifier, a thickener, a stabilizer or a gelling agent. The base refers to a component among the materials of cosmetic and the like, which is mainly used for giving a shape to a product and also called an excipient.

(297) While the shape of the cosmetic, perfumery, pharmaceutical product and quasi-drug blended with the gel composition of the present invention is not particularly limited, for example, paste, gel, cream, particle, solid, stick, sphere, sheet and the like can be mentioned. Among these, paste, gel, solid, sphere and sheet are preferable.

(298) Specific examples of the cosmetic, perfumery and quasi-drug include solid preparations such as adiaphoretic, chapstick, lip rouge, sun protectant, solid foundation, concealer, foundation primer, cleansing agent and the like, gel or gel dispersions or emulsions such as facial cleanser, cleansing gel, milky lotion, cream (massage cream, cold cream), moisture gel, facial mask, after shaving gel, milky liquid foundation, blush, mascara, shampoo, rinse, hair-growth drug, treatment, conditioner, tic, set lotion, hair cream, hair wax, hair mousse, permanent wave solution, hair dye, hair coloring, hair manicure, sunscreen oil, hand soap, and the like, aromatic, cataplasm and the like. Preferred are adiaphoretic, lip rouge, chapstick, cream, milky lotion, and sun protectant, and more preferred are adiaphoretic, lip rouge, cream, milky lotion, and sun protectant.

(299) Specific examples of the pharmaceutical product include external preparations such as ointment, cream, gel and the like, adhesive preparation, suppository and the like.

(300) Cosmetic, perfumery, pharmaceutical product and quasi-drug containing the gel composition of the present invention can be produced according to a conventional method.

EXAMPLE

(301) While the present invention is explained in further detail by illustrating Examples, the present invention is not limited to the following Examples.

(302) <Production Method of Gel>

(303) A appropriate amount (wt %) of component A″ was added to component B″ at the ratio shown in Table 1B, and the mixture was heated and stirred in an oil bath to uniformly dissolve A″ and B″. An appropriate amount of the solution was added to solutions of an oil agent (component C″) or an oil agent (component C″) and an emulsifier (component D″) previously heated and dissolved at the ratios shown in Tables 2B-6B, and the mixtures were heated and stirred until uniform dissolution. The solutions were filled in jar type containers and stood at room temperature for 5 hr to give gel compositions.

(304) Various blending examples of component A″ and component B″ in which the ratio of A″-1 and A″-2 components is different are shown in Table 1B.

(305) TABLE-US-00029 TABLE 1B blend No. blend blend blend blend blend blend blend blend blend blend blend blend 1 2 3 4 5 6 7 8 9 10 11 12 ratio .fwdarw. EB-21:GP-1(A2:A1) .fwdarw. 2:3 2:3 2:3 2:3 2:3 2:3 2.5:1 3:1 4:1 4:1 7:1 7:1 component A″ dibutyl ethylhexanoyl 16 20 8 8 8 8 14.3 30 32 16 17.5 17.5 glutamide (EB-21) dibutyl lauroyl 24 30 12 12 12 12 5.7 10 8 4 2.5 2.5 glutamide (GP-1) component B″ ethanol 60 50 60 60 component B″ myristic acid 80 80 component B″ 2-octyldodecanol 80 component B″ oleyl alcohol 80 component B″ pentylene glycol 80 80 80 80 total (wt %) 100 100 100 100 100 100 100 100 100 100 100 100
<Study of Uniform Dissolution Temperature of Composition>

(306) An appropriate amount of component (B″) was measured into a glass vial, and an appropriate amount of component (A″) was added to component (B″). The mixture was heated and stirred in an oil bath to uniformly dissolve component (A″) in component (B″). Component (C″) was measured into a different glass vial, uniformly mixed and dissolved, an appropriate amount of a gelling agent solution was added to a solution of other components, and the mixture was mixed by stirring. The temperature of the bath was increased at intervals of 5° C., and the temperature was raised until the mixture became a uniform solution. The temperature at which the uniform solution of the mixture was obtained was taken as the uniform dissolution temperature of the formulation. In Examples 1-1 to 1-3, component (A″) alone was directly added to component (C″) instead of component (A″)+(B″), and the uniform dissolution temperature of the formulation was examined.

(307) <Evaluation of Softness of Gel>

(308) The breaking strength of the gel was measured by FUDOH Rheometer D-series (manufactured by Rheotech Co., Ltd.). A gel composition with a flat surface set in the machine together with the container, and the measurement was performed using an adapter having a diameter of 10 mm under the conditions of an entrance speed of 6 cm/min and a load of 200 g. The breaking strength value was automatically calculated by the machine.

(309) The following evaluation was made based on the breaking strength values:

(310) very preferable (⊙): 15-70 g/cm.sup.2 (very soft gel was formed)

(311) preferable (◯): 71-150 g/cm.sup.2 (soft gel was formed)

(312) not very preferable (Δ): 151-300 g/cm.sup.2 (formed gel is hard)

(313) not preferable (x): higher than 300 g/cm.sup.2 (formed gel is considerably hard).

(314) <Evaluation of Sweating of Gel Formulation>

(315) (1) Sweating of Gel (when Returned from −5° C. to 25° C.)

(316) (1-1) The gel composition filled in a container was stored in a thermostatic tank at −5° C. overnight. The stored sample was taken out from the thermostatic tank at −5° C., and gradually warmed to 25° C. over 1 hr.

(317) (1-2) The Sample was further Stored at Room Temperature for One Day.

(318) Immediately after each of the operations of (1-1) and (1-2), the area of the droplets on the surface of the gel composition was confirmed. The area of the droplets covering the surface of the gel composition and the total area of the gel composition were measured by an image processing (Image J), the former was divided by the latter, and the calculated value was shown as
percentage (K): calculated value (K)−(area of droplet/total area of gel composition)×100%.

(319) The evaluation points were given to the gel compositions after each of the operations (1-1) and (1-2) according to the following criteria. 5 points: value of Knot more than 0.5% 4.5 points: value of K higher than 0.5% and not more than 2% 4 points: value of K higher than 2% and not more than 5% 3.5 points: value of K higher than 5% and not more than 10% 3 points: value of K higher than 10% and not more than 15% 2.5 points: value of K higher than 15% and not more than 25% 2 points: value of K higher than 25% and not more than 35% 1.5 points: value of K higher than 35% and not more than 50% 1 point: value of K higher than 50%

(320) Using the average of the evaluation points of the gel compositions after each of the operations (1-1) and (1-2), sweating of the gelling agents (when returned from −5° C. to 25° C.) was evaluated according to the following evaluation criteria.

(321) very preferable (⊙): evaluation average points of not less than 4.0

(322) preferable (◯): evaluation average points of not less than 3.0 and less than 4.0

(323) not very preferable (Δ): evaluation average points of not less than 2.0 and less than 3.0

(324) unpreferable (x): evaluation average points of not less than 1.0 and less than 2.0

(325) (2) Sweating of Gel (40° C.)

(326) (2-1) The Gel Composition Filled in a Container was Stored in a Thermostatic Tank at 40° C. Overnight.

(327) (2-2) The Sample was further Stored at Room Temperature for One Day.

(328) Immediately after each of the operations of (2-1) and (2-2), the area of the droplets on the surface of the gel composition was confirmed and evaluated in the same manner as in the above-mentioned (1).

(329) (3) Stability Evaluation Total Points

(330) In each gel composition, the total evaluation points after respective operations (1-1), (1-2), (2-1) and (2-2) were evaluated as the stability evaluation total points of the gel composition. The total evaluation points of the gel composition before and after addition of a new component were evaluated. When the stability evaluation total points increased by the addition of the component, the gel composition was judged to have become more stable by the addition of the component.

(331) <Evaluation of Easiness of Taking from Container in Use>

(332) Six expert panelists scooped with one finger a gel composition filled in a jar type container, and evaluated ease of penetration of the finger into the gel composition and easiness of taking the gel composition with one finger according to the following criteria.

(333) 1) easy penetration into the gel composition without destroying the whole shape of the composition and easy scooping of the gel composition with one finger . . . 4 points

(334) 2) penetration into the gel composition without destroying the whole shape of the composition and scooping of the gel composition with one finger . . . 3 points

(335) 3) difficult penetration into the gel composition without destroying the whole shape of the composition and difficult scooping of the gel composition with one finger . . . 2 points

(336) 4) unattainable penetration into the gel composition without destroying the whole shape of the composition and unattainable scooping of the gel composition with one finger . . . 1 point

(337) Based on the average evaluation points by the expert panelists, the following determination was made.

(338) ⊙: evaluation average points 3.5 or above

(339) ◯: evaluation average points 2.5 or above and less than 3.5

(340) Δ: evaluation average points 1.5 or above and less than 2.5

(341) x: evaluation average points less than 1.5

(342) <Sensory Evaluation when Applied to Skin>

(343) Whether a smooth and thick liquid that does not leave solid gel particles on the skin when applied to the skin is provided was evaluated. Six expert panelists measured 0.2 g of the gel composition, placed same on the back of the hand, rubbed with a finger five times, and broke the gel composition into a liquid. Easiness of application of the gel composition during application thereof was evaluated according to the following criteria.

(344) 1) when broken by rubbing, solid gel particle do not remain and gel composition is broken very smoothly to give thick liquid composition . . . 4 points

(345) 2) when broken by rubbing, solid gel particle do not remain mostly and gel composition is broken smoothly to give thick liquid composition . . . 3 points

(346) 3) when broken by rubbing, solid gel particles remain a little, gel composition is not easily broken smoothly and thick liquid composition is not easily afforded . . . 2 points

(347) 4) when broken by rubbing, solid gel particles remain a lot, gel composition is not broken smoothly and thick liquid composition is not afforded . . . 1 point

(348) Based on the average evaluation points by the expert panelists, the following determination was made.

(349) ⊙: evaluation average points 3.5 or above

(350) ◯: evaluation average points 2.5 or above and less than 3.5

(351) Δ: evaluation average points 1.5 or above and less than 2.5

(352) x: evaluation average points less than 1.5

(353) The results are shown in Tables 2B-6B.

(354) As shown in Table 2B, it was found that addition of component B″ enabled uniform dissolution of the formulation at a lower temperature, thus affording benefits in production.

(355) TABLE-US-00030 TABLE 2B evaluation formulation No. Example Example Example Example Example Example 1-1 1-2 1-3 1-4 1-5 1-6 EB-21:GP-1(A2:A1) component 4:1 4:1 4:1 4:1 4:1 4:1 component C″ wheat germ oil 98.5 92.5 component C″ tri(caprylic acid/capric acid)glyceryl 98.5 92.5 component C″ cetyl ethylhexanoate 98.5 92.5 component A″ − 2 EB-21 1.2 1.2 1.2 component A″ − 1 GP-1 0.3 0.3 0.3 component A″ + B″ mixtureof blend 10 7.5 7.5 7.5 total (wt %) 100.0 100.0 100.0 100.0 100.0 100.0 evaluation items uniform dissolution temperature >145 >125 >135 <105 <95 <95 (° C.) of formulation softness of gel ○ ○ ○ ⊙ ⊙ ⊙ sweating of gel (40° C.) ○ ○ ○ ⊙ ○ ○ sweating of gel (−5° C. .fwdarw. 25° C.) ○ ○ ○ ○ ○ ○ easiness of taking when in use ○ ○ ○ ○ ○ ○ sensory evaluation on application ○ ○ ○ ○ ⊙ ⊙

(356) In Example 1-1 to Example 1-3, satisfactory soft gel compositions were obtained. In Examples 1-4 to 1-6, satisfactory soft gel compositions were obtained even at a low production temperature by blending component B″.

(357) Comparison of the properties of the gel compositions having different-blending ratios of A″-1 and A″-2 components is shown in Tables 3B and 4B.

(358) TABLE-US-00031 TABLE 3B evaluation formulation No. Comparative Comparative Comparative Comparative Example 2-1 Example 2-2 Example 2-3 Example 2-4 EB-21:GP-1 (A2:A1) component 2:3 2:3 2:3 2:3 component wheat germ oil 92.5 96.25 C″ component tri(caprylic acid/capric 92.5 C″ acid)glyceryl component cetyl ethylhexanoate 92.5 C″ component mixture of blend 6 7.5 A″ + B″ component mixture of blend 3 7.5 7.5 A″ + B″ component mixture of blend 1 3.75 A″ + B″ total (wt %) 100.0 100.0 100.0 100.0 evaluation softness of gel ◯ Δ Δ Δ item sweating of gel (40° C.) Δ Δ Δ ◯ sweating of gel (−5° C. .fwdarw. 25° C.) X Δ Δ ◯ easiness of taking when in X X X X use sensory evaluation on X X X X application

(359) TABLE-US-00032 TABLE 4B evaluation formulation No. Example Example Example Example 2-1 2-2 2-3 2-4 EB-21:GP-1 (A2:A1) component 7:1 7:1 4:1 4:1 component C″ wheat germ oil 92.5 96.25 component C″ tri(caprylic acid/capric 92.5 acid)glyceryl component C″ cetyl ethylhexanoate 92.5 component A″ + B″ mixture of blend 11 7.5 component A″ + B″ mixture of blend 12 7.5 7.5 component A″ + B″ mixture of blend 9 3.75 total (wt %) 100.0 100.0 100.0 100.0 evaluation item softness of gel ⊙ ⊙ ⊙ ⊙ sweating of gel (40° C.) ⊙ ⊙ ⊙ ⊙ sweating of gel (−5° C. .fwdarw. 25° C.) ◯ ⊙ ◯ ◯ easiness of taking when in use ◯ ◯ ◯ ◯ sensory evaluation on application ◯ ◯ ◯ ◯

(360) As shown in Table 5B, it was confirmed that the addition of component A″ further improved stability of the gel compositions.

(361) TABLE-US-00033 TABLE 5B Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. 3-1 3-2 3-3 3-4 3-5 3-6 3-7 3-8 3-9 3-10 3-11 EB-21:GP-1(A2:A1) 7:1 7:1 7:1 7:1 7:1 7:1 7:1 7:1 7:1 7:1 7:1 component C″ jojoba seed oil 92.5 87.5 87.5 component C″ tri(caprylic acid/capric acid)glyceryl 92.5 87.5 component C″ cetyl ethylhexanoate 92.5 87.5 87.5 87.5 87.5 87.5 component A″ + B″ mixture of blend 11 7.5 7.5 7.5 7.5 7.5 7.5 7.5 7.5 7.5 7.5 7.5 component D″ polyglyceryl-10 dioleate (HLB11) 5.0 5.0 component D″ PEG-40 glyceryl triisostearate (HLB11) 5.0 component D″ PEG-40 glyceryl isostearate (HLB15) 5.0 5.0 component D″ polyglyceryl-10 cocoate (HLB16) 5.0 5.0 component D″ polyglyceryl-3 cocoate (HLB12) 5.0 total (wt %) 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 evaluation item breaking strength of gell (g/cm.sup.2) 56 47 62 39 33 43 49 43 15 29 24 sweating of gel (40° C.) 4 5 4.5 5 5 5 5 5 3 5 5 sweating of gel (40° C.) .fwdarw. one day later 5 5 5 5 5 5 5 5 3 5 5 sweating of gel (−5° C. .fwdarw. 25° C.) 3.5 5 3.5 5 4.5 5 5 5 3 3.5 3.5 sweating of gel (−5° C. .fwdarw. 25° C.) .fwdarw. 3.5 5 3.5 5 5 5 5 5 3 4 3.5 one day later stability evaluation total points 16 20 16.5 20 19.5 20 20 20 12 17.5 17 increase of stability evaluation total — 4 — 3.5 3 3.5 3.5 3.5 — 5.5 5 points by addition of component D

(362) Comparison of the properties of actual gel cleansing formulations for cosmetics is shown in Table 6B.

(363) TABLE-US-00034 TABLE 6B Comp. Comp. Comp. Comp. Ex. Ex. Ex. Ex. Ex. 4-1 Ex. 4-2 Ex. 4-3 Ex. 4-4 4-1 4-2 4-3 4-4 EB-21:GP-1(A2:A1) component 2:3 2:3 2:3 2:3 3:1 2.5:1 7:1 7:1 component C″ wheat germ oil 23.5 23.5 23.5 26 26 26.6 25.5 27.5 component C″ cetyl ethylhexanoate 16 16 16 18 18 18 16.5 19.5 component C″ isopropyl myristate 9.5 9.5 9.5 10 11 10.7 9.4 9.5 component C″ tri(caprylic acid/capric acid)glyceryl 9.5 9.5 9.5 10 11 10.7 10.4 15 component C″ shea butter 10 10 10 11 11 10.7 10.4 component D″ polyglyceryl-10 dioleate 14 14 14 16 17 16 17.5 18.2 component D″ polyglyceryl-2 oleate 2.5 2.5 2.5 3 3 3 2.8 2.8 component A″ + B″ mixture of blend 4 15 component A″ + B″ mixture of blend 6 15 component A″ + B″ mixture of blend 5 15 component A″ + B″ mixture of blend 2 6 component A″ + B″ mixture of blend 8 3 component A + B mixture of blend 7 4.3 component A + B mixture of blend 11 7.5 7.5 total (wt%) 100 100 100 100 100 100 100 100 evaluation item softness of gel Δ ○ Δ Δ ⊙ ⊙ ⊙ ⊙ sweating of gel (40° C.) Δ x x ○ ⊙ ○ ⊙ ⊙ sweating of gel (−5° C. .fwdarw. 25° C.) Δ x x Δ ⊙ ○ ⊙ ⊙ easiness of taking when in use x x x x ○ ○ ⊙ ⊙ sensory evaluation on application x x x x ○ ○ ⊙ ⊙

(364) TABLE-US-00035 TABLE 7B Reference Formulation Example soft gel formulation for cleansing: component C″ wheat germ oil 27.4 component C″ cetyl ethylhexanoate 19.4 component D″ polyglyceryl-10 dioleate 18.4 component C″ tri(caprylic acid/capric acid)glyceryl 15.5 component C″ isopropyl myristate 9.0 component D″ polyglyceryl-2 oleate 2.8 component A″ dibutyl ethylhexanoyl glutamide (EB-21) 1.3 component A″ dibutyl lauroyl glutamide (GP-1) 0.2 component B″ dipropyleneglycol 6.0 flavor q.s. total (wt %) 100.0

INDUSTRIAL APPLICABILITY

(365) Using the gelling agent and gel composition of the present invention, cosmetic, perfumery, quasi-drug and the like with soft and smooth sense of use can be produced.

(366) This application is based on patent application Nos. 2016-208184, 2017-061620, 2016-208183 and 2017-028516 filed in Japan, the contents of which are incorporated in full herein.

(367) Where a numerical limit or range is stated herein, the endpoints are included. Also, all values and subranges within a numerical limit or range are specifically included as if explicitly written out.

(368) As used herein the words “a” and “an” and the like carry the meaning of “one or more.”

(369) Obviously, numerous modifications and variations of the present invention are possible in light of the above teachings. It is therefore to be understood that, within the scope of the appended claims, the invention may be practiced otherwise than as specifically described herein.

(370) All patents and other references mentioned above are incorporated in full herein by this reference, the same as if set forth at length.