Lung condition monitoring device
11432744 · 2022-09-06
Assignee
Inventors
- Mitradip Bhattacharjee (Guwahati, IN)
- Dipankar Bandyopadhyay (Guwahati, IN)
- Harshal B. Nemade (Guwahati, IN)
Cpc classification
A61B5/085
HUMAN NECESSITIES
A61B5/097
HUMAN NECESSITIES
G01N27/121
PHYSICS
A61B5/082
HUMAN NECESSITIES
International classification
Abstract
The present invention discloses a Lung condition monitoring device for performing ultrafast detection of humidity level in exhaled air while breathing out and therefrom detect condition of the human lungs in real time. The Lung 5 condition monitoring device comprises a mouthpiece for forcibly exhaling air there through, one or more humidity sensor to measure the variable electrical resistance based on level of adsorption of water molecules thereon of the humidity content of exhaled air and real time monitoring unit operatively connected to said humidity sensor and having correlating means for correlating 10 the change in humidity level and related variation in the electrical resistance due to exhalation to peak flow rate of the exhaled air for monitoring lung condition. The Lung condition monitoring device is also capable of wireless data transfer to any peripheral computing device such as mobile phone via wireless connectivity and show the test results on the mobile phone display with the help of a 15 proprietary application embodied in the phones operating system. The mobile interface increases the portability, data monitoring, and user friendliness of the device. Further, the mobile interface helps in storage and analysis of big time data for prognosis, diagnosis, and therapeutic purposes.
Claims
1. A lung condition monitoring device comprising: a mouthpiece for forcibly exhaling air therethrough; a humidity sensor configured to output variable electrical resistance based on a level of adsorption of water molecules thereon of humidity of the exhaled air; a real time monitoring unit operatively connected to said humidity sensor and configured for correlating a change in humidity level and related variation in the electrical resistance due to exhalation to a peak flow rate of the exhaled air for monitoring lung condition; and a heating element for rapid desorption of the water molecules from the humidity sensor and recovery of the humidity sensor for subsequent detection of the humidity level.
2. The lung condition monitoring device as claimed in claim 1, further comprising a humidity sensor unit exposed to a rapid decrease in the electrical resistance of the humidity sensor due to the adsorption of the water molecules from the exhaled breathing air during forced exhalation; wherein: said mouthpiece includes an open area to receive exhaled breathing air from a user, wherein said mouthpiece, at a remote end, is operatively connected to said humidity sensor in the humidity sensor unit; said heating element cooperates with said humidity sensor to increase temperature of the humidity sensor post adsorption of the water molecules for rapid desorption of the water molecule from the humidity sensor and recovery of the humidity sensor for subsequent detection of the humidity level; and said real time monitoring unit is configured to detect a lung condition and lung function parameters by detecting a maximum change in the electrical resistance across the humidity sensor and correlating the same with the peak flow rate of exhalations from lung.
3. The lung condition monitoring device as claimed in claim 2, wherein the humidity sensor unit comprises: at least one opening slot to allows the exhaled breathing air to flow in; one or more holes on a sidewall of humidity sensor unit's housing to operate as outlets of the air from the humidity sensor unit; and sensor supporting structure to hold the humidity sensor in the humidity sensor unit.
4. The lung condition monitoring device as claimed in claim 3, wherein the humidity sensor includes: one or more films of porous cadmium sulfide (CdS) nanoparticles, each of said films of porous CdS nanoparticles comprising i. a thermally conductive paper substrate having gold (Au) nanoparticles embedded thereon, and ii. the porous CdS nanoparticles on said Au nanoparticles embedded thermally conductive paper substrate to constitute a nanoparticle surface for rapid adsorption of the water molecules; and silver electrodes for operatively connecting said nanoparticle surfaces with the real time monitoring unit.
5. The lung condition monitoring device as claimed in claim 4, wherein the heating element is placed between the humidity sensors and the sensor supporting structure.
6. The lung condition monitoring device as claimed in claim 5, wherein the heating element comprises: a metallic wire in coil form embedded in a polymer matrix or substrate; and two electrodes for connecting a power source with the coil to operate the heating element and generate heat.
7. The lung condition monitoring device as claimed in claim 5, further comprising a thermistor positioned between the sensor supporting structure and the heating element to sense temperature of the heating element and act as a negative feedback to control the temperature.
8. The lung condition monitoring device as claimed in claim 6, wherein the heating element includes copper wire of diameter 180 μm coiled in a 1 centimeter square area having 80 turns fixed in an adhesive paper substrate to keep the structure intact.
9. The lung condition monitoring device as claimed in claim 2, wherein the real time monitoring unit includes: a small cabinet for housing a control assembly and the power source; a plurality of indicator LEDs on housing of the real time monitoring unit for indicating status of the lung; and a power switch operatively connected with the power source to activate/deactivate the device and ON-OFF indicator LED to display activation of the device.
10. The lung condition monitoring device as claimed in claim 9, wherein the control assembly includes: a heating element control module comprising a square pulse generator to operate and maintain the heating element's temperature; a sensor unit control module having said humidity sensor and configured to connect the humidity sensor with the indicator LED control module via associated resistive network; and an indicator LED control module having a resistive network operatively connecting the indicator LEDs with the humidity sensor to activate one or more of the indicator LEDs depending on the condition of the lung of the user.
11. The lung condition monitoring device as claimed in claim 10, wherein the indicator LED control module is configured to activate one or more of the indicator LEDs depending on the change in the electrical resistance of the humidity sensor and correlating the same with the peak flow rate of exhalations from lung; wherein the peak flow rate of exhalations from the lung is an indicator of degree of obstruction in airways of bronchi and linearly vary with the change in the electrical resistance of the humidity sensor due to the adsorption of the water molecules from the exhaled breathing air during forced exhalation; and wherein higher value of the peak flow rate of exhalations indicates healthy lungs and lower values indicate the diseased state of the lungs.
12. The lung condition monitoring device as claimed in claim 11, wherein the indicator LED control module is configured to activate any one or more of three indicator LEDs for indicating status of the lung and includes the resistive network adapted to drive current through the LEDs for activating all the LEDs when resistance of the sensor unit after adsorption of the water molecules from the exhaled breathing air corresponds to the peak flow rate of exhalations from a healthy lung; activating only two LEDs when resistance of the sensor unit after adsorption of the water molecules from the exhaled breathing air corresponds to the peak flow rate of exhalations from a lung in condition of COPD; and activating only one LED when resistance of the sensor unit after adsorption of the water molecules from the exhaled breathing air corresponds to the peak flow rate of exhalations from a lung in need of emergency medical attention.
13. The lung condition monitoring device as claimed in claim 6, further comprising a voltage regulator connected to the power source to maintain the stable output voltage to all components of the device.
14. The lung condition monitoring device as claimed in claim 1, further comprising a wireless communication interface having wireless data exchange connectivity with a peripheral computing device to facilitate wireless data transfer from the humidity sensor to the peripheral computing deivce and display the same on the peripheral computing device screen; wherein the connected periphal computing device facilitates storage and analysis of big time data for prognosis, diagnosis, and therapeutic purposes and also increases portability, data monitoring, and user friendliness of the device.
15. The lung condition monitoring device as claimed in the claim 14, further including an open standard mobile application for the peripheral computing device operating system configured for integrating with the present lung condition monitoring device and the wireless communication interface to enable monitoring of the lung function on the screen of the peripheral computing device through wireless data exchange.
Description
BRIEF DESCRIPTION OF THE ACCOMPANYING DRAWINGS
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DETAILED DESCRIPTION OF THE INVENTION WITH REFERENCE TO THE ACCOMPANYING DRAWINGS
(14) As stated hereinbefore, the present invention discloses a portable Lung condition monitoring device configured for performing ultrafast detection of humidity level in exhaled air while breathing out for checking the fitness of the lungs.
(15) The present Lung condition monitoring device operates as a point-of care testing gadget or device for monitoring condition of the lung and advantageously quantifies the humidity level of exhaled air in order to detect the change in humidity level once user blows the exhaled air through said Lung condition monitoring device.
(16) The relative humidity of the exhaled air from the human lungs is about 95 -100%, which is much larger than the relative humidity of ambient air at room temperature and pressure. Thus, when a human forcibly exhales air on the present Lung condition monitoring device, the change in the humidity level changes electrical resistance across humidity sensor unit of the Lung condition monitoring device. The maximum change in the resistance across the humidity sensor unit can be correlated with the peak flow rate of exhalations from the lungs for detecting lung status and many other health parameters.
(17) The present Lung condition monitoring device comprises said humidity sensing unit having nanoparticle based humidity sensor, heating arrangement having at least one heating element cooperative with the humidity sensor, a mouthpiece and a real time monitoring unit.
(18) Reference is first invited from the accompanying
(19) The humidity sensor unit 103 is operatively connected to the real-time monitoring unit 104. The real-time monitoring unit comprises plurality of lighting source such as LEDs 105 for indicating status of the lung. The connecting wire 111 from the humidity sensor unit 103 and the connecting wire 112 from the real-time monitoring unit 104 are connected by a connector 113.
(20) In a preferred embodiment, an ON-OFF switch 107 and an ON-OFF indicator LED 114 provided on the real-time monitoring unit 104. Housing of the real-time monitoring unit 104 and the mouthpiece 101 are normally made from plastic or polycarbonate material and preferably includes an O shaped metallic support ring 109 and 110 to protect the housing from cracking and damage.
(21) Reference is next invited from the accompanying
(22) The accompanying
(23) Reference is next invited from the accompanying
(24) The nanoparticle based humidity sensors 301T of the humidity sensor unit 103 preferably include one or more films of porous CdS nanoparticles which are not only capable of rapid adsorption of water molecules under the sudden exposure of water vapor, but also can desorb water immediately upon heating.
(25) Reference is next invited from the accompanying
(26) The accompanying
(27) The
(28) The heating element includes metallic wire of a coil form 301B1 which is embedded in a polymer (preferably polydimethylsiloxane (PDMS)) matrix 301B2. Two electrodes 301B3 are provided for connecting a power source with the coil 301B1 to operate the heating element and generate heat.
(29) As shown in the figure, the CdS nanoparticle sensors 301T includes sensor paper 301T1 substrate having the CdS nanoparticles and silver electrodes 301T2.
(30) In the present invention, the CdS nanoparticles are first synthesized by using chemical precipitation technique [refer to, Qi et. al., Nano Letters, 2001, 1, 61-65] wherein CdCl.sub.2 is used as the source of Cd.sup.2+ ions and Na.sub.2S, 9H.sub.2O is used as the source of S.sup.2− ions. Methanol acted as a capping agent.
(31) In the beginning of the synthesis a 20 ml of 0.1M NaOH solution is prepared which is then slowly added to 2.5 ml of methanol that acted as capping agent. This prepared solution is then sonicated for 1 hr in ultra-sonication bath. Freshly prepared Na.sub.2S solution is then added to the aforementioned solution drop by drop with vigorous stirring, which turned the colorless solution to a yellowish solution. Prepared CdS nanoparticles are accumulated at the bottom of the container and 50 μl CdS nanoparticle is dropped on the filter paper i.e. the sensor paper substrate (Whatman cat no. 1001 125 grade 1) of dimension 1 cm×1 cm using micropipette. The sample is then kept for 12 h to get dried. Then silver paste is used to make the silver electrodes and the prepared sample is kept again for 24 h in order to get dried.
(32) In the present invention, the paper used for fabrication of the sensor is pretreated with Au nanoparticle solution for embedding the Au nanoparticle within the paper substrate, wherein the paper is kept inside Au nanoparticle solution for 2 h and then dried in hot-air oven. Pretreatment of the paper substrate increase the thermal conductivity of the paper substrate as the embedded Au nanoparticles played important role in conduction of heat. Pretreatment of the paper with Au nanoparticle solution helped in improving the recovery time with less temperature requirement.
(33) In a preferred embodiment, the heating element is fabricated by using Cu wire of diameter 180 μm. A long copper wire is coiled in a 1 cm square area and made a square having 80 turns of copper wire. This is then fixed in an adhesive paper substrate to keep the structure intact. Then the CdS humidity sensor is integrated with the heating element by placing it top of the heating element and connecting it to the connector.
(34) The accompanying
(35) Since the exhaled breathing air issuing out of a human lung is exceedingly humid, when the user exhales air on the mouthpiece 101, the immediate vicinity of the CdS nanoparticle humidity sensors 301T of the humidity sensor unit 103 becomes crowded with a large number of water molecules. Consequently, a part of these water molecules are adsorbed by the porous CdS nanoparticles, as schematically shown in the
(36) Experiments suggest that when RH of the surroundings are relatively low (˜5%), a Langmuir monolayer of water molecules on the surface of the CdS nanoparticles having active OH groups may not change the electrical resistance significantly [refer to, Demir et al., Ind. Eng. Chem. Res. 2011, 50, 5606]. However, at higher RH values (>60%) condensation of water molecules on CdS surface due to multilayer physical adsorption lead to a significant decrease in the electrical resistance. In such a scenario, the reduction in the electrical resistance can be attributed to the enhancement in the ionic conduction, which happened because of the production of ionic hydroxyl groups from the adsorbed water molecules when the electric field applied across the CdS surface. Thus, the CdS nanoparticle based humidity sensors employed in the humidity sensor unit of the present lung status testing device show a rapid reduction in the electrical resistance while the forced exhalation takes place. However, the rate of desorption of the water molecule is rather slow because of the higher level of RH in the surroundings. In order to expedite the rate of desorption and reduce the time for recovery of the humidity sensors, the heating element is used to increase temperature of the CdS nanoparticle humidity sensors which rapidly enhance rate of desorption of water molecule from the nanoparticle sensor surface.
(37) Reference is next invited from the accompanying
(38) The accompanying
(39) The real time monitoring unit 104 is connected to the humidity sensor unit 103 as illustrated in the
(40) Reference is next invited from the accompanying
(41) As shown in the referred figure, the heating element control module which is associated with the heating element (RH) 301B is situated in right side of the sensor unit control module. The heating element control module includes a square pulse generator that helps in maintaining the heating element temperature. The display LED control module which displays the sensor response through the indicator LEDs is situated in the left side of the of the sensor unit control module.
(42) Three indicator LEDs 105 (L.sub.R, L.sub.Y and L.sub.G) are connected to the sensor (R.sub.s) via three variable resistances (R.sub.1, R.sub.2 and R.sub.3) of the indicator LED control module, as shown in the
(43) Reference is next invited from the accompanying
(44) The insets also show the real images of humidity sensor unit and heating element. The accompanying figures (B) and (C) show the real image of the device prototype after integration. The figure (D) shows the repetition of the change in resistance for three cycles of breathing.
(45) In the present Lung condition monitoring device, the peak flow rate (F.sub.R) of exhaled air is measured, which is the maximum speed of exhalation of a person and a potential indicator of the degree of obstruction in the airways of the bronchi. Dependence of the change in the resistance of the nanoparticle humidity sensor due to adsorption of water in the nanoparticle sensor surface with the peak flow rate is shown in the accompanying
(46) The accompanying
(47) As stated herein before, the indicator LED control module of the present device can activate one or more of the indicator LEDs depending on the change in the electrical resistance of the sensor unit and correlating the same with the peak flow rate of exhalations from lung, wherein the peak flow rate of exhalations from the lung is linearly vary with the change in the resistance of the nanoparticle sensor due to the adsorption of the water molecules from the exhaled breathing air during forced exhalation. In an embodiment of the present Lung condition monitoring device, wherein the indicator LED control module is configured to activate any one or more of three indicator LEDs for indicating status of the lung includes the resistive network adapted to drive current through the LEDs for activating all the LEDs when resistance of the sensor unit after adsorption of the water molecules from the exhaled breathing air corresponds to the peak flow rate of exhalations from healthy lung or activating only two LEDs when resistance of the sensor unit after adsorption of the water molecules from the exhaled breathing air corresponds to the peak flow rate of exhalations from lung in condition of COPD or activate only one LED when resistance of the sensor unit after adsorption of the water molecules from the exhaled breathing air corresponds to the peak flow rate of exhalations from lung seeking emergency medical attention.
(48) To illustrate the above selective driving of the current through the LEDs, reference is now invited from the accompanying
(49) The
(50) To illustrate operation of the present device, it is assumed that R.sub.SA=10 kΩ, which is the resistance value of R.sub.S in case of
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(52) Similarly, when F.sub.R is above safety level, the current,
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(54) When, F.sub.R is below safety level, the total current is I.sub.1 and in this condition the current through R.sub.1 is,
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and the current through R.sub.2 is,
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(57) If one put all the values, then I.sub.1 =0.675 mA, I.sub.11=0.45 mA and I.sub.12=0.225 mA, which confirms that in this case only the red LED (L.sub.R) is turned on to indicate the necessity of medical assistance required. In contrast, if the F.sub.R is above safety level, then I.sub.2=1.08 mA, I.sub.21=0.72 mA and I.sub.22=0.36 mA, which ensures both the green and red LEDs (L.sub.G and L.sub.R) are turned on to confirm fitness of the Lungs.
(58) This device can also be operated using a peripheral computing device such as smart mobile phone with an open standard ‘Android’ operating system in which an ‘Android’ application is developed specific to the Lung condition monitoring device. The
(59) Although the above embodiments of the invention have been illustrated as a unique Lung condition monitoring device which advantageously detect condition of the lung in real time and operate as point-of care testing gadgets or devices for checking fitness of the lungs of a person, the present device, can also be engineered even for detecting humidity level in the air. At its present state, the sensor gives a sharp and rapid response for the forcibly flowing highly humid air such as human exhaled air. However, it has the capability to detect the humidity level of air, and to remove the effect of ambient humidity, the heating element is introduced which confirms that the ambient water molecules cannot effect the sensor response during measuring the lung health.
(60) Those skilled in the art will recognize, however, that the embodiments of the invention described herein are only examples provided for the purpose of describing the advancement only and that they are not the only embodiments of the Lung condition monitoring device which can be developed involving the advancement. Thus other changes and modifications known to those of ordinary skill are intended to be included within the scope of the present invention.