MEDICAMENT FOR TREATING STROKE CAUSED BY DEEP FUNGAL INFECTIONS

Abstract

Use of addition and subtraction of the Banxia Baizhu Tianma Decoction in preparation of medicines or health products for treating strokes caused by deep fungal infections. The present invention relates to the field of medical and health care, and specifically relates to use of chemical ingredients, i.e. alkaloids and volatile oils contained in plant raw materials such as Gastrodia elata, Pinellia ternata, Atractylodes macrocephala, Poria cocos, fresh orange peel and Liquorice to prepare drugs or health products for treating strokes caused by deep fungal infections.

Claims

1. A medicine for treating strokes caused by deep fungal infections, characterized in that the active pharmaceutical ingredients of the medicine comprise alkaloids and/or volatile oils extracted from Gastrodia elata, alkaloids and/or volatile oils extracted from Pinellia ternata, alkaloids and/or volatile oils extracted from Atractylodes macrocephala, alkaloids and/or volatile oils extracted from Poria cocos, alkaloids and/or volatile oils extracted from fresh orange peel, and alkaloids and/or volatile oils extracted from Liquorice; methods for preparing the medicine include: taking alkaloids of Gastrodia elata, alkaloids of Pinellia ternata, alkaloids of Atractylodes macrocephala, alkaloids of Poria cocos, alkaloids of fresh orange peel and alkaloids of Liquorice and mixing them in a certain proportion; adding various conventional excipients required to prepare different dosage forms thereto; and preparing pharmaceutically acceptable dosage forms; taking volatile oils of Gastrodia elata, volatile oils of Pinellia ternata, volatile oils of Atractylodes macrocephala, volatile oils of Poria cocos, volatile oils of fresh orange peel and volatile oils of Liquorice and mixing them in a certain proportion; adding various conventional excipients required to prepare different dosage forms thereto; and preparing pharmaceutically acceptable dosage forms; taking alkaloids and volatile oils of Gastrodia elata, alkaloids and volatile oils of Pinellia ternata, alkaloids and volatile oils of Atractylodes macrocephala, alkaloids and volatile oils of Poria cocos, alkaloids and volatile oils of fresh orange peel and alkaloids and volatile oils of Liquorice and mixing them in a certain proportion; adding various conventional excipients required to prepare different dosage forms thereto; and preparing pharmaceutically acceptable dosage forms.

2. The medicine according to claim 1, characterized in that the weight parts of the alkaloids in the active pharmaceutical ingredients of the medicine are: 0.01-50 weight parts of alkaloids of Gastrodia elata, 0.01-50 weight parts of alkaloids of Pinellia ternata, 0.01-50 weight parts of alkaloids of Atractylodes macrocephala, 0.01-50 weight parts of alkaloids of Poria cocos, 0.01-50 weight parts of alkaloids of fresh orange peel, 0.01-50 weight parts of alkaloids of Liquorice.

3. The medicine according to claim 1, characterized in that the weight parts of the volatile oils in the active pharmaceutical ingredients of the medicine are: 0.01-50 weight parts of volatile oils of Gastrodia elata, 0.01-50 weight parts of volatile oils of Pinellia ternata, 0.01-50 weight parts of volatile oils of Atractylodes macrocephala, 0.01-50 weight parts of volatile oils of Poria cocos, 0.01-50 weight parts of volatile oils of fresh orange peel, 0.01-50 weight parts of volatile oil of Liquorice.

4. The medicine according to claim 1 or 2 or 3, characterized in that a dose of the medicine to be taken daily is further preferable as: the weight of alkaloids and volatile oils contained in 50 g of Gastrodia elata, the weight of alkaloids and volatile oils contained in 35 g of Pinellia ternata, the weight of alkaloids and volatile oils contained in 30 g of Atractylodes macrocephala, the weight of alkaloids and volatile oils contained in 30 g of Poria cocos, the weight of alkaloids and volatile oils contained in 40 g of fresh orange peel, the weight of alkaloids and volatile oils contained in 25 g of Liquorice.

5. The medicine according to claim 1 or 2 or 3 or 4, characterized in that the methods for preparing the medicine include: extracting alkaloids and/or volatile oils from plant raw materials such as Gastrodia elata, Pinellia ternata, Atractylodes macrocephala, Poria cocos, fresh orange peel and Liquorice to prepare the medicine; wherein methods for extracting the alkaloids can be determined after extraction with organic solvents, and the alkaloids are extracted from plants using different solvents; supercritical fluid extraction is the first choice, followed by membrane separation, ultrasonic extraction or Soxhlet extraction; as a method for extracting the volatile oils, supercritical fluid extraction is the first choice, followed by organic solvent extraction: continuous reflux extraction or cold leaching using petroleum ether, diethyl ether or other organic solvents, or extraction using steam distillation or a cold pressing method; and preparing pharmaceutically acceptable dosage forms such as tablets, powder injections, soft capsules, granules or capsules using conventional methods for preparing pharmaceutical chemicals.

6. The medicine according to claim 1 or 2 or 4 or 5, characterized in that the methods for preparing the medicine include: according to the weight parts of the selected raw materials, extracting alkaloids from 50 g of Gastrodia elata, 35 g of Pinellia ternata, 30 g of Atractylodes macrocephala, 30 g of Poria cocos, 40 g of fresh orange peel, and 25 g of Liquorice respectively using supercritical fluid extraction or membrane separation; mixing the alkaloids and adding conventional excipients thereto; and preparing tablets according to a conventional process for preparing pharmaceutical chemicals.

7. The medicine according to claim 1 or 3 or 4 or 5, characterized in that the methods for preparing the medicine include: according to the weight parts of the selected raw materials, extracting volatile oils from 50 g of Gastrodia elata, 35 g of Pinellia ternata, 30 g of Atractylodes macrocephala, 30 g of Poria cocos, and 25 g of Liquorice respectively using supercritical fluid extraction or organic solvent extraction; extracting volatile oils from 40 g of fresh orange peel using a cold pressing method; then mixing the volatile oils and adding conventional excipients thereto; and preparing soft capsules or granules according to a conventional process for preparing pharmaceutical chemicals.

8. The medicine according to claim 1 or 2 or 3 or 4 or 5 or 6 or 7, characterized in that, according to clinical symptoms, the medicine can be selectively added with alkaloids and/or volatile oils contained in raw materials such as Uncaria rhynchophylla, Ligusticum wallichii, monkshood, Berba aristolochiae mollissimae and Caulis sinomenii.

9. The medicine according to claim 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8, characterized in that the methods for preparing the medicine include: extracting alkaloids and/or volatile oils from various plant raw materials such as Gastrodia elata, Pinellia ternata, Atractylodes macrocephala, Poria cocos, fresh orange peel and Liquorice or Uncaria rhynchophylla or Ligusticum wallichii or monkshood or Berba aristolochiae mollissimae or Caulis sinomenii to prepare the medicine; and preparing pharmaceutically acceptable dosage forms such as tablets, powder injections, soft capsules, granules or capsules using conventional methods for preparing pharmaceutical chemicals.

10. The medicine according to claim 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9, characterized in that the scope of application of the medicine includes applications in medical drugs, health foods, health care products, animal drugs, and animal feed.

Description

SPECIFIC IMPLEMENTATION MODE

Embodiment 1

[0056] The active pharmaceutical ingredients of the medicine for treating strokes caused by deep fungal infections in the embodiment include: alkaloids contained in 50 g of Gastrodia elata, alkaloids contained in 35 g of Pinellia ternata, alkaloids contained in 30 g of Atractylodes macrocephala, alkaloids contained in 30 g of Poria cocos, alkaloids contained in 40 g of fresh orange peel, and alkaloids contained in 25 g of Liquorice.

[0057] According to the weight parts of the selected raw materials, alkaloids were extracted from 50 g of Gastrodia elata, 35 g of Pinellia ternata, 30 g of Atractylodes macrocephala, 30 g of Poria cocos, 40 g of fresh orange peel, and 25 g of Liquorice respectively using supercritical fluid extraction or membrane separation. The alkaloids were mixed and added with conventional excipients, and tablets were prepared according to a conventional process for preparing pharmaceutical chemicals.

Embodiment 2

[0058] The active pharmaceutical ingredients of the medicine for treating strokes caused by deep fungal infections in the embodiment include: volatile oils contained in 50 g of Gastrodia elata, volatile oils contained in 35 g of Pinellia ternata, volatile oils contained in 30 g of Atractylodes macrocephala, volatile oils contained in 30 g of Poria cocos, volatile oils contained in 40 g of fresh orange peel, and volatile oils contained in 25 g of Liquorice.

[0059] According to the weight parts of the selected raw materials, volatile oils were extracted from 50 g of Gastrodia elata, 35 g of Pinellia ternata, 30 g of Atractylodes macrocephala, 30 g of Poria cocos, and 25 g of Liquorice respectively using supercritical fluid extraction or organic solvent extraction. Volatile oils were extracted from 40 g of fresh orange peel using a cold pressing method. Then the volatile oils were mixed and added with conventional excipients, and soft capsules or granules were prepared according to a conventional process for preparing pharmaceutical chemicals.

Embodiment 3

[0060] The active pharmaceutical ingredients of the medicine for treating strokes caused by deep fungal infections in the embodiment include: alkaloids contained in 30 g of Gastrodia elata, alkaloids contained in 30 g of Pinellia ternata, alkaloids contained in 20 g of Atractylodes macrocephala, alkaloids contained in 20 g of Poria cocos, alkaloids contained in 30 g of fresh orange peel, alkaloids contained in 15 g of Liquorice, alkaloids contained in 20 g of Uncaria rhynchophylla, and alkaloids contained in 15 g of Ligusticum wallichii.

[0061] According to the weight parts of the selected raw materials, alkaloids were extracted from 30 g of Gastrodia elata, 30 g of Pinellia ternata, 20 g of Atractylodes macrocephala, 20 g of Poria cocos, 30 g of fresh orange peel, 15 g of Liquorice, 20 g of Uncaria rhynchophylla, and 15 g of Ligusticum wallichii respectively using supercritical fluid extraction or membrane separation. The alkaloids were mixed and added with conventional excipients, and tablets were prepared according to a conventional process for preparing pharmaceutical chemicals.

Embodiment 4

[0062] The active pharmaceutical ingredients of the medicine for treating strokes caused by deep fungal infections in the embodiment include: volatile oils contained in 30 g of Gastrodia elata, volatile oils contained in 30 g of Pinellia ternata, volatile oils contained in 20 g of Atractylodes macrocephala, volatile oils contained in 20 g of Poria cocos, volatile oils contained in 30 g of fresh orange peel, and volatile oils contained in 15 g of Liquorice, volatile oils in 20 g of Uncaria rhynchophylla, and volatile oils contained in 15 g of Ligusticum wallichii.

[0063] According to the weight parts of the selected raw materials, volatile oils were extracted from 30 g of Gastrodia elata, 30 g of Pinellia ternata, 20 g of Atractylodes macrocephala, 20 g of Poria cocos, 15 g of Liquorice, 20 g of Uncaria rhynchophylla, and 15 g of Ligusticum wallichi respectively using supercritical fluid extraction or organic solvent extraction. Volatile oils were extracted from 30 g of fresh orange peel using a cold pressing method. Then the volatile oils were mixed and added with conventional excipients, and soft capsules or granules were prepared according to a conventional process for preparing pharmaceutical chemicals. Embodiment 5

[0064] The active pharmaceutical ingredients of the medicine for treating strokes caused by deep fungal infections in the embodiment include: alkaloids contained in 25 g of Gastrodia elata, alkaloids contained in 15 g of Pinellia ternata, alkaloids contained in 15 g of Atractylodes macrocephala, alkaloids contained in 15 g of Poria cocos, alkaloids contained in 20 g of fresh orange peel, alkaloids contained in 10 g of Liquorice, alkaloids contained in 20 g of Ligusticum wallichii, and alkaloids contained in 10 g of monkshood.

[0065] According to the weight parts of the selected raw materials, alkaloids were extracted from 25 g of Gastrodia elata, 15 g of Pinellia ternata, 15 g of Atractylodes macrocephala, 15 g of Poria cocos, 20 g of fresh orange peel, 10 g of Liquorice, 20 g of Ligusticum wallichii, and 10 g of monkshood respectively using supercritical fluid extraction or membrane separation. The alkaloids were mixed and added with conventional excipients, and tablets were prepared according to a conventional process for preparing pharmaceutical chemicals.

Embodiment 6

[0066] The active pharmaceutical ingredients of the medicine for treating strokes caused by deep fungal infections in the embodiment include: volatile oils contained in 25 g of Gastrodia elata, volatile oils contained in 15 g of Pinellia ternata, volatile oils contained in 15 g of Atractylodes macrocephala, volatile oils contained in 15 g of Poria cocos, volatile oils contained in 25 g of fresh orange peel, volatile oils contained in 10 g of Liquorice, volatile oils contained in 20 g of Ligusticum wallichii, and volatile oils contained in 10 g of monkshood.

[0067] According to the weight parts of the selected raw materials, volatile oils were extracted from 25 g of Gastrodia elata, 15 g of Pinellia ternata, 15 g of Atractylodes macrocephala, 15 g of Poria cocos, 10 g of Liquorice, 20 g of Ligusticum wallichii, and 10 g of monkshood respectively using supercritical fluid extraction or organic solvent extraction. Volatile oils were extracted from 25 g of fresh orange peel using a cold pressing method. Then the volatile oils were mixed and added with conventional excipients, and soft capsules or granules were prepared according to a conventional process for preparing pharmaceutical chemicals.

Embodiment 7

[0068] The active pharmaceutical ingredients of the medicine for treating strokes caused by deep fungal infections in the embodiment include: alkaloids contained in 20 g of Gastrodia elata, alkaloids contained in 15 g of Pinellia ternata, alkaloids contained in 15 g of Atractylodes macrocephala, alkaloids contained in 10 g of Poria cocos, alkaloids contained in 20 g of fresh orange peel, alkaloids contained in 10 g of Liquorice, alkaloids contained in 15 g of Uncaria rhynchophylla, alkaloids contained in 15 g of Ligusticum wallichii, alkaloids contained in 10 g of monkshood, alkaloids contained in 15 g of Berba aristolochiae mollissimae, and alkaloids contained in 15 g of Caulis sinomenii.

[0069] According to the weight parts of the selected raw materials, alkaloids were extracted from 20 g of Gastrodia elata, 15 g of Pinellia ternata, 15 g of Atractylodes macrocephala, 15 g of Poria cocos, 20 g of fresh orange peel, 10 g of Liquorice, 15 g of Uncaria rhynchophylla, 15 g of Ligusticum wallichii, 10 g of monkshood, 15 g of Berba aristolochiae mollissimae, and 15 g of Caulis sinomenii respectively using supercritical fluid extraction or membrane separation. The alkaloids were mixed and added with conventional excipients, and tablets were prepared according to a conventional process for preparing pharmaceutical chemicals.

Embodiment 8

[0070] The active pharmaceutical ingredients of the medicine for treating strokes caused by deep fungal infections in the embodiment include: volatile oils contained in 20 g of Gastrodia elata, volatile oils contained in 15 g of Pinellia ternata, volatile oils contained in 15 g of Atractylodes macrocephala, volatile oils contained in 15 g of Poria cocos, volatile oils contained in 20 g of fresh orange peel, volatile oils contained in 10 g of Liquorice, volatile oils contained in 15 g of Uncaria rhynchophylla, volatile oils contained in 15 g of Ligusticum wallichii, volatile oils contained in 10 g of monkshood, volatile oils contained in 15 g of Berba aristolochiae mollissimae, and volatile oils contained in 15 g of Caulis sinomenii.

[0071] According to the weight parts of the selected raw materials, volatile oils were extracted from 20 g of Gastrodia elata, 15 g of Pinellia ternata, 15 g of Atractylodes macrocephala, 15 g of Poria cocos, 10 g of Liquorice, 15 g of Uncaria rhynchophylla, 15 g of Ligusticum wallichii, 10 g of monkshood, and 15 g of Berba aristolochiae mollissimae respectively using supercritical fluid extraction or organic solvent extraction. Volatile oils were extracted from 20 g of fresh orange peel and 15 g Caulis sinomenii using a cold pressing method. Then the volatile oils were mixed and added with conventional excipients, and soft capsules or granules were prepared according to a conventional process for preparing pharmaceutical chemicals.

Embodiment 9

[0072] The active pharmaceutical ingredients of the medicine for treating strokes caused by deep fungal infections in the embodiment include: alkaloids contained in 15 g of Gastrodia elata, alkaloids contained in 15 g of Pinellia ternata, alkaloids contained in 10 g of Atractylodes macrocephala, alkaloids contained in 10 g of Poria cocos, alkaloids contained in 15 g of fresh orange peel, alkaloids contained in 10 g of Liquorice, alkaloids contained in 12 g of Ligusticum wallichii, alkaloids contained in 12 g of Berba aristolochiae mollissimae, and alkaloids contained in 15 g of Caulis sinomenii.

[0073] According to the weight parts of the selected raw materials, alkaloids were extracted from 15 g of Gastrodia elata, 15 g of Pinellia ternata, 10 g of Atractylodes macrocephala, 10 g of Poria cocos, 15 g of fresh orange peel, 10 g of Liquorice, 12 g of Ligusticum wallichii, 12 g of Berba aristolochiae mollissimae, and 15 g of Caulis sinomenii respectively using supercritical fluid extraction or membrane separation. The alkaloids were mixed and added with conventional excipients, and tablets were prepared according to a conventional process for preparing pharmaceutical chemicals.

Embodiment 10

[0074] The active pharmaceutical ingredients of the medicine for treating strokes caused by deep fungal infections in the embodiment include: volatile oils contained in 15 g of Gastrodia elata, volatile oils contained in 15 g of Pinellia ternata, volatile oils contained in 10 g of Atractylodes macrocephala, volatile oils contained in 10 g of Poria cocos, volatile oils contained in 15 g of fresh orange peel, volatile oils contained in 10 g of Liquorice, volatile oils contained in 12 g of Ligusticum wallichii, volatile oils contained in 12 g of Berba aristolochiae mollissimae, and volatile oils contained in 15 g of Caulis sinomenii.

[0075] According to the weight parts of the selected raw materials, volatile oils were extracted from 15 g of Gastrodia elata, 15 g of Pinellia ternata, 10 g of Atractylodes macrocephala, 10 g of Poria cocos, 10 g of Liquorice, 12 g of Ligusticum wallichii, 12 g of Berba aristolochiae mollissimae respectively using supercritical fluid extraction or organic solvent extraction. Volatile oils were extracted from 15 g of fresh orange peel and 15 g Caulis sinomenii using a cold pressing method. Then the volatile oils were mixed and added with conventional excipients, and soft capsules or granules were prepared according to a conventional process for preparing pharmaceutical chemicals.

[0076] Of course, the embodiments above are only for the purpose of clearly illustrating the examples given, rather than limiting the implementation mode. Based upon the above description, other different changes or modifications can be also made by those skilled in the art. It is unnecessary and impossible to present all possible embodiments herein, and the obvious changes or modifications thus extended are still within the scope of protection of the present invention.

[0077] Inventive Step and Novelty of the Invention

[0078] The inventive step and novelty of the medicines provided by the present invention lie in the following: the medicines provided by the present invention are prepared by extracting alkaloids and/or volatile oils from plant raw materials such as Gastrodia elata, Pinellia ternata, Atractylodes macrocephala, Poria cocos, fresh orange peel, and Liquorice to prepare pharmaceutical chemicals, that is, alkaloids of Gastrodia elata, alkaloids of Pinellia ternata, alkaloids of Atractylodes macrocephala, alkaloids of Poria cocos, alkaloids of fresh orange peel, alkaloids of Liquorice are mixed in a certain proportion and are added with conventional excipients, and tablets are prepared according to a conventional process for preparing pharmaceutical chemicals. Compared with the existing pharmaceutical chemicals, which are medicines made from alkaloids extracted from a single plant, it is a significant improvement. It can reduce the content of a single alkaloid in a medicine and reduce the toxic reaction caused by the excessive dosage of the single alkaloid. For example, morphine obtained from opium has a strong analgesic effect, because it is a single alkaloid, and its dose has to be too large in order to achieve the curative effect, and the toxic side effects appear easily. Moreover, the medicines provided by the invention can have a more effective targeting action on different organs and vascular tissues because of the synergistic effect of the multiple alkaloids.

[0079] Compared with traditional Chinese medicines in form of tablets, capsules, granules and the like prepared using modern methods for preparing drugs, the medicines provided by the present invention show significant progress. Not all Chinese medicines are necessarily obtained from herbs, but also from animals and minerals. The main feature of modern Chinese medicines is that it is possible to know only the main ingredients, that is, to know the chemical ingredients that can cure diseases rather than to know all the ingredients. The chemical ingredients of the medicines provided by the present invention are only alkaloids and volatile oils.

[0080] The pharmacological mechanism of the medicines provided by the invention is clear. The pharmacological mechanism of alkaloids and volatile oils contained in Gastrodia elata, Pinellia ternata, Atractylodes macrocephala, Poria cocos, fresh orange peel, Liquorice, Uncaria rhynchophylla, Ligusticum wallichii, monkshood, Berba aristolochiae mollissimae and Caulis sinomenii is that of antifungal drugs. The inventor thinks that strokes are caused by deep fungal infections, and emboli in the blood are hyphal clusters that are formed by fungal multiplication and fall into the blood. Furthermore, alkaloids and volatile oils contained in Gastrodia elata, Pinellia ternata, Atractylodes macrocephala, Poria cocos, fresh orange peel, Liquorice, Uncaria rhynchophylla, Ligusticum wallichii, monkshood, Berba aristolochiae mollissimae and Caulis sinomenii have an effect of killing fungi and decomposing their hyphae, that is, they have a thrombolytic effect. Furthermore, they can treat fungi in different arteries and veins and can restore the blood circulation in the different arteries and veins.

[0081] Technical Effect

[0082] The traditional prescription the “Banxia Baizhu Tianma Decoction” has been clinically proved to be safe and effective. Using the “Banxia Baizhu Tianma Decoction” added with Acorns calamus and Curcuma longa as the basic prescription and a Chinese medicine method of adding and subtracting a decoction based on the syndrome differentiation, Sun Liting treated 14 cases of cerebral arteriosclerosis and 11 cases of vertebrobasilar insufficiency with excellent results. Using the active pharmaceutical ingredients of Gastrodia elata, Pinellia ternata, Atractylodes macrocephala, Poria cocos, orange peel and Liquorice as the basic prescription, and using a traditional method to add and subtract Uncaria rhynchophylla, Ligusticum wallichii, monkshood, Berba aristolochiae mollissimae and Caulis sinomenii according to the syndrome differentiation, the applicant treated 3 cases of apoplexy caused by deep fungal infections. After half a month of taking the medicine, the clinical symptoms of the apoplexy were significantly improved. The medicine provided by the invention is an extract of active pharmaceutical ingredients based on the traditional classical prescription “Banxia Baizhu Tianma Decoction”, wherein volatile oils and alkaloids contained in plant raw materials such as Pinellia ternata, Atractylodes macrocephala, Gastrodia elata, Poria cocos, fresh orange peel, and Liquorice are extracted to prepare a medicine or health product for treating strokes caused by fungi. Compared with traditional methods for preparing drugs, the chemical ingredients of the medicine or health product provided by the invention are known, and the effectiveness thereof is obvious.