SILICONE SUBSTITUTE NATURAL ADDITIVE COMPOSITION, PROCESS FOR OBTAINING THE SAME AND ITS USE
20220296487 · 2022-09-22
Assignee
Inventors
Cpc classification
International classification
Abstract
A natural additive composition capable of replacing silicone components in a wide variety of types of application, preferably in the field of cosmetic, veterinary cosmetic, dermocosmetic products has, in terms of percent by weight of the total weight of the composition: (a) 0.5% to 80% polysaccharides, monosaccharides and derivatives thereof; (b) 10% to 99.5% monohydric alcohols, polyhydric alcohols, unsaturated aliphatic alcohols, glycerides; and (c) 0% to 40% components depending on the type of application, which can be abrasives, emollients, rheology modifiers, moisture absorbers, etc.
Claims
1. A silicone substitute natural additive composition comprising in mass relative to the total mass of the composition: (a) from 0.5% to 80% of polysaccharides, monosaccharides, and derivatives thereof; (b) from 10% to 99.5% of monohydric alcohols, polyhydric alcohols, unsaturated aliphatic alcohols, glycerides; and (c) from 0 to 40% of an additive.
2. The silicone substitute natural additive composition according to claim 1, wherein the component (a) being selected from the group comprising: sucrose, lactose, fructose, glucose, galactose, maltose, arabinose, xylose, mannose, sucrose, sorbitol, and glucose.
3. The silicone substitute natural additive composition according to claim 2, wherein the component (a) being glucose.
4. The silicone substitute natural additive composition according to claim 1, wherein the component (b) being selected from the group comprising: ethylene glycol, propylene glycol, glycerin, butylene glycol.
5. A silicone substitute natural additive composition according to claim 4, wherein the component (b) being propylene glycol and/or glycerin.
6. The silicone substitute natural additive composition according to claim 1, wherein the component (c) being isopropyl palmitate and/or isoamyl laurate, or silica.
7. The silicone substitute natural additive composition according to claim 1, further comprising in mass relative to the total mass of the composition: (a) from 0.5% to 70% of monosaccharides, polysaccharides and derivatives thereof selected from the group comprising: sucrose, lactose, fructose, galactose, maltose, arabinose, xylose, mannose, sucrose, sorbitol, and glucose; (b) from 10% to 99.5% of ethylene glycol, propylene glycol, glycerin, butylene glycol; and (c) from 0% to 40% of an additive.
8. The silicone substitute natural additive composition according to claim 7, comprising in mass relative to the total mass of the composition: (a) from 0.5% to 70% of glucose; (b) from 10% to 99.5% of propylene glycol and/or glycerin; and (c) from 0% to 40% of fatty acid esters and/or silica.
9. A process for obtaining a silicone substitute natural additive composition as defined in claim 1, comprising the following steps: (a) in a reactor, add from 10% to 99.5% by mass of monohydric alcohols, polyhydric alcohols, unsaturated aliphatic alcohols, glycerides, and raise the temperature from 60° C. to 80° C.; (b) stir for 30 to 50 minutes and soon after slowly add from 0.5% to 60% by mass of monosaccharides, polysaccharides and derivatives thereof until a homogeneous mixture is achieved between 30 to 50 minutes; and (c) add from 0% to 40% by mass of an additive, and mix from 30 to 50 minutes.
10. The process according to claim 9, comprising the following steps: (a) in a reactor, add from 10% to 99.5% by mass of emollients and/or solvents selected from the group comprising: ethylene glycol, propylene glycol, glycerin, butylene glycol and raise the temperature from 60° C. to 80° C.; (b) stir for 30 to 50 minutes and soon after slowly add from 0.5% to 60% by mass of monosaccharides, polysaccharides and derivatives thereof selected from the group comprising: sucrose, lactose, fructose, galactose, maltose, arabinose, xylose, mannose, sucrose, sorbitol and glucose; until a homogeneous mixture is achieved between 30 to 50 minutes; and (c) add from 0% to 40% by mass of an additive, and mix from 30 to 50 minutes.
11. A process according to claim 10, comprising: (a) in a reactor, add from 10% to 99.5% by mass of propylene glycol and/or glycerin and raise the temperature from 60° C. to 80° C.; (b) stir for 30 to 50 minutes and soon after slowly add from 0.5 to 60% by mass of glucose until a homogeneous mixture is achieved between 30 to 50 minutes; and (c) add from 0 to 40% by weight of fatty acid esters and/or abrasives and mix it from 30 to 50 minutes.
12. (canceled)
13. The silicone substitute natural additive composition according to claim 1, wherein the additive comprises one or more of an abrasive, an emollients, a fatty acid ester, a rheology modifier, and a moisture absorber.
14. The process according to claim 9, wherein the additive comprises one or more of an abrasive, an emollients, a fatty acid ester, a rheology modifier, and a moisture absorber.
Description
DESCRIPTION OF THE FIGURES
[0033] Attached herewith are found the figures that illustrate the results achieved with experiments of the invention:
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DETAILED DESCRIPTION OF THE INVENTION
[0048] The present invention employs in its composition 0.5 to 80% by weight in mass relative to the total mass of the composition of polysaccharide, monosaccharides, and derivatives thereof, selected from the group comprising: sucrose, lactose, fructose, glucose, galactose, maltose, arabinose, xylose, mannose, sucrose, sorbitol, glucose, among others. Preferably, glucose is employed.
[0049] Corn glucose, also referred to as glucose syrup, is a food syrup obtained by hydrolysis of the corn starch. It is mainly a concentrated source of calories with very little nutritional value. In recent years, corn glucose has emerged as a popular substitute for sugar. The demand for corn glucose in the food processing industry has also witnessed a strong growth in recent years. It is used primarily as a key ingredient in foods commercially prepared to improve taste, improving color, adding volume, and providing a smooth texture to food. As aid in preventing sugar crystallization, corn glucose is widely used in confections, jams, canned fruits, ice creams, ice creams, beverages, dairy desserts, cookies, candies, cereals, ketchup, sauces, vitaminic tonic and cough medicaments. According to the IMARC Group, the overall corn glucose market has reached a volume of about 3.6 million tons in 2018, representing a CAGR of almost 1% for 2011-2018.
[0050] Corn glucose may be employable as carbohydrate according to the invention.
[0051] Glucose is a simple sugar of molecular formula C.sub.6H.sub.12O.sub.6. Glucose is the most abundant monosaccharide, being produced naturally mainly by plants and algae during photosynthesis of water and carbon dioxide, using solar energy.
[0052] The glucose employed in the composition according to the invention can be employed in the form of dry glucose syrup, which is obtained by spray drying of syrups from carbon hydrates concentrates derived from the partial hydrolysis of the starch.
[0053] The composition also employs 10% to 99.5% of monohydric alcohols, polyhydric alcohols, unsaturated aliphatic alcohols, glycerides, selected from the group comprising: ethylene glycol, propylene glycol, glycerin, butylene glycol, ethyl hexyl glycerin, caprylyl glycol, etc. Preferably, propylene glycol and/or glycerin is used.
[0054] The composition may also present another component (c) selected from the group comprising fatty acid derivatives selected from the group comprising the acid: lauryl, cetyl, stearyl, myristyl, oleyl, stearic, lauric, myristic, palmitic, oleic; linoleic. Preferably, isopropyl palmitate and/or isoamyl laurate are used.
[0055] Component (c) can also be an abrasive, such as silica.
[0056] One embodiment of the silicone substitute natural composition according to the invention comprises in mass relative to the total mass of the composition:
[0057] (a) from 0.5% to 70% of monosaccharides, polysaccharides and derivatives thereof are selected from the group comprising: sucrose, lactose, fructose, glucose, galactose, maltose, arabinose, xylose, mannose, sucrose, sorbitol and glucose;
[0058] (b) from 10% to 99.5% of ethylene glycol, propylene glycol, glycerin, butylene glycol;
[0059] (c) from 0 to 40% of other components according to the type of application, which may be abrasives, emollients, rheology modifiers, moisture absorbers, etc.
[0060] Another embodiment of the silicone substitute natural composition according to the invention comprises in mass relative to the total mass of the composition:
[0061] (a) from 0.5% to 70% of glucose;
[0062] (b) from 10% to 99.5% of propylene glycol and/or glycerin;
[0063] (c) from 0 to 40% of fatty acid esters and/or silica.
[0064] A preferred embodiment of the silicone substitute natural composition according to the invention comprises in mass relative to the total mass of the composition:
[0065] (a) from 2% to 60% of glucose;
[0066] (b) from 20 to 99.5% of propylene glycol and/or glycerin;
[0067] (c) from 0 to 35% of fatty acid esters, silica.
[0068] The process for obtaining the silicone substitute natural composition according to the invention comprises the following steps:
[0069] (a) in a reactor, add from 10% to 99.5% by mass of monohydric alcohols, polyhydric alcohols, unsaturated aliphatic alcohols, glycerides, and raise the temperature from 60° C. to 80° C.;
[0070] (b) stir for 30 to 50 minutes and soon after slowly add from 0.5% to 70% by mass of monosaccharides, polysaccharides and derivatives thereof until a homogeneous mixture is achieved between 30 to 50 minutes;
[0071] (c) add from 0% to 40% by mass of other components according to the type of application, such as abrasives, emollients, fatty acid esters, rheology modifiers, moisture absorbents, etc., and mix from 30 to 50 minutes.
[0072] Another process for obtaining the silicone substitute natural composition according to the invention comprises the following steps:
[0073] (a) in a reactor, add from 10% to 99.5% by mass of emollients and/or solvents selected from the group comprising: ethylene glycol, propylene glycol, glycerin, butylene glycol and raise the temperature from 60° C. to 80° C.;
[0074] (b) stir for 30 to 50 minutes and soon after slowly add from 0.5% to 60% by mass of monosaccharides, polysaccharides and derivatives thereof selected from the group comprising: sucrose, lactose, fructose, glucose, galactose, maltose, arabinose, xylose, mannose, sucrose, sorbitol and glucose; until a homogeneous mixture is achieved between 30 to 50 minutes;
[0075] (c) add from 0% to 40% by mass of other components according to the type of application, such as abrasives, emollients, fatty acid esters, rheology modifiers, moisture absorbents, etc., and mix from 30 to 50 minutes.
[0076] Another preferred embodiment of the process for obtaining the silicone substitute natural composition according to the invention comprises the following steps:
[0077] (a) in a reactor, add from 10% to 99.5% by mass of propylene glycol and/or glycerin and raise the temperature from 60° C. to 80° C.;
[0078] (b) stir for 30 to 50 minutes and soon after slowly add from 0.5 to 60% by mass of glucose until a homogeneous mixture is achieved between 30 to 50 minutes;
[0079] (c) add from 0 to 40% by weight of fatty acid esters and/or drying agent.
[0080] Glucose is slowly added, since it has to be added very slowly to achieve good dispersion. The reactor rotation can be between 150 and 320 rpm, preferably between 200 and 300 rpm.
[0081] The use of the silicone substitute natural composition according to the invention in cosmetic products, veterinary cosmetics, dermocosmetics, automotive, and the like, substantially free of silicone. By “substantially free of silicone” is meant that the formulations are formulated without the inclusion of initial compounds containing silicone groups.
[0082] The following is a few examples of embodiments of the invention that are not to be taken to limit the scope of the invention.
EXAMPLES
Example 1
[0083] Table 1 below indicates the mass ratio of raw material used in this example:
TABLE-US-00001 TABLE 1 Example 1 12% glucose 88% glycerin Brookfield viscosity at 25° C. Max. 2,500 cps
[0084] In a jacketed reactor, glycerin is added, and the temperature is raised up to 80° C. It is stirred for 40 minutes and soon after this it is slowly added to the glucose, since it has to be added very slowly to achieve good dispersion. It is mixed for 40 minutes until get homogeneous and with a Brookfield viscosity at 25° C. of 2,500 cps. After measuring the viscosity, the product has been found to have reached the parameters desired in the specification. It is important to leave it cool to fill the product, passing the same previously by a filter to remove impurities
[0085] The obtained product was tested on hair, wherein the comparative results are illustrated in
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[0088] To obtain the attached graphs, a panel was used where blind tests were performed by applying to each participant the product obtained as the example on half of the hair, wherein the other half had the silicone product applied.
[0089] It was asked for each volunteer to place a note for each attribute, for both (product according to the invention and silicone), ranging from 1 to 5, as explained below and whose results obtained are in the attached graphs:
note 1=Bad
note 2=Regular
note 3=Good
note 4=Very good
note 5=Excellent
[0090] This same methodology was employed in the other examples. In the case of example 4, the methodology was the same, except that the products were applied onto the skin.
Example 2
[0091] Table 2 below indicates the mass ratio of raw material used in this example:
TABLE-US-00002 TABLE 2 Example 2 9.3% glucose 48% glycerin 42.7% propylene glycol Brookfield viscosity at 25° C. Max. 400 cps
[0092] In a jacketed reactor, glycerin is added, and the temperature is raised up to 90° C. Then, propylene glycol is added. It is stirred for 40 minutes and soon after this it is slowly added to the glucose, since it has to be added very slowly to achieve good dispersion. It is mixed for 40 minutes until get homogeneous and with a Brookfield viscosity at 25° C. of 400 cps. After measuring the viscosity, the product has been found to have reached the parameters desired in the specification. After this, the product can be filled, passing previously by a filter for removing the impurities.
[0093] The obtained product was tested on hair, wherein the comparative results are illustrated in
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Example 3
[0096] Table 3 below indicates the mass ratio of raw material used in this example:
TABLE-US-00003 TABLE 3 Example 3 33.5% glucose 66.5% propylene glycol Brookfield viscosity at 25° C. Max. 1,200 cps
[0097] In a jacketed reactor, propylene glycol is added, and the temperature is raised up to 90° C. It is stirred for 50 minutes and soon after this it is slowly added to the glucose, since it has to be added very slowly to achieve good dispersion. It is mixed for 40 minutes until get homogeneous and with a Brookfield viscosity at 25° C. of 1,200 cps. After measuring the viscosity, the product has been found to have reached the parameters desired in the specification. After this, the product can be bottled, passing previously by a filter for removing the impurities.
[0098] The obtained product was tested on hair, wherein the comparative results are illustrated in
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Example 4
[0101] Table 4 below indicates the mass ratio of raw material used in this example:
TABLE-US-00004 TABLE 4 Example 4 5% glucose 40% glycerin 55% propylene glycol Brookfield viscosity at 25° C. Max. 250 cps
[0102] In a jacketed reactor, glycerin is added, and the temperature is raised up to 90° C. Then, propylene glycol is added. It is stirred for 40 minutes and soon after this it is slowly added to the glucose, since it has to be added very slowly to achieve good dispersion. It is mixed for 40 minutes until get homogeneous and with a Brookfield viscosity at 25° C. of 250 cps. After measuring the viscosity, the product has been found to have reached the parameters desired in the specification. After this, the product can be filled, passing previously by a filter for removing the impurities.
[0103] The obtained product was tested on the skin, wherein the comparative results are illustrated in
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Example 5
[0105] Table 5 below indicates the mass ratio of raw material used in this example:
TABLE-US-00005 TABLE 5 Example 5 43.5% glucose 56.5% propylene glycol Brookfield viscosity at 25° C. Max. 6,000 cps
[0106] In a jacketed reactor, propylene glycol is added, and the temperature is raised up to 90° C. It is stirred for 40 minutes and soon after this it is slowly added to the glucose, since it has to be added very slowly to achieve good dispersion. It is mixed for 60 minutes until get homogeneous and with a Brookfield viscosity at 25° C. of 6,000 cps. After measuring the viscosity, the product has been found to have reached the parameters desired in the specification. Since this product is very viscous, it is necessary to bottle it with the same viscosity measurement temperature and always pass it through a filter to remove impurities.
[0107] The obtained product was tested on hair, wherein the comparative results are illustrated in
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[0109]
Example 6
[0110] Table 6 below indicates the mass ratio of raw material used in this example:
TABLE-US-00006 TABLE 6 Example 6 43% glucose 57% propylene glycol Brookfield viscosity at 25° C. Max. 8,000 cps
[0111] In a jacketed reactor, propylene glycol is added, and the temperature is raised up to 90° C. It is stirred for 40 minutes and soon after this it is slowly added to the glucose, since it has to be added very slowly to achieve good dispersion. It is mixed for 60 minutes until get homogeneous and with a Brookfield viscosity at 25° C. of 8,000 cps. Since this product is very viscous, it is necessary to bottle it with the same viscosity measurement temperature and always pass it through a filter to remove impurities.
[0112] The obtained product was tested on hair, wherein the comparative results are illustrated in
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[0114]
Example 7
[0115] Table 7 below indicates the mass ratio of raw material used in this example:
TABLE-US-00007 TABLE 7 Example 7 2% glucose 30% of a 50% solution of cetrimonium chloride 68% propylene glycol
[0116] In a jacketed reactor, propylene glycol is added, and the temperature is raised up to 80° C. It is stirred for 40 minutes and soon after this it is slowly added to the glucose, since it has to be added very slowly to achieve good dispersion. It is mixed for 30 minutes, letting it get cold, until it gets homogeneous and with a Brookfield viscosity at 25° C. of 400 cps. After the addition of cetrimonium chloride, it is stirred for more 30 minutes. Soon after the product is ready to be filled, which is made by passing it through a filter to remove the impurities.
[0117] The obtained product was tested on hair, wherein the comparative results are illustrated in
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[0119]
Example 8
[0120] 1. Introduction
[0121] Skin hydration is related to several mechanisms present in the epidermis and dermis and has an important influence on the physiology, mechanical properties of the skin and the homeostasis of healthy skin. Hydration depends on several factors such as, for example, the integrity of the stratum corneum of the epidermis and tight adhesion junctions between the keratinocytes to prevent water loss from the skin. Additionally, there are proteins and agents such as endogenous glycerol and hyaluronic acid present in the dermis and epidermis that contribute to skin hydration.
[0122] In this sense, the importance of water channels in the cell membrane that are called aquaporins and how they influence hydration was identified. 13 types of aquaporins have been identified in mammals. For human skin, the presence and importance of aquaporin 3 has been demonstrated by several studies. Aquaporin 3 is a water and glycerol channel present in keratinocytes of the epidermis. The lack of this channel when genetically manipulated in mice, led to reduced skin hydration and reduced skin elasticity. Additionally, it was observed that the expression of aquaporin 3 is affected by aging and continuous sun exposure that lead to reduced expression of this channel.
[0123] In patients with psoriasis lesions, a reduction in aquaporin 3 levels is observed.
[0124] Thus, the importance and relationship of aquaporin 3 with skin hydration is understood. Products can act on skin hydration through changes in aquaporin 3 expression, which reinforces the importance of researching this channel and its expression in human keratinocytes.
[0125] 2. Objective
[0126] Evaluate the action of samples on aquaporin 3 levels using keratinocyte cell culture.
[0127] 3. Relevance of the Study
[0128] The experimental conditions used are accepted and consistent with the methodologies currently applied in the international scientific community, as well as the use of cells under appropriate culture conditions.
[0129] 4. Sample Description
[0130] Two samples were used:
TABLE-US-00008 Internal Code Manu- Reference/ In vitro facture Storage Sample name Batch nucleous date conditions DIMETHICONE 350 NI NV.73.02 NI Room Temperature INVENTION 350 NI NV.74.02 NI Room Temperature *NI = not informed
[0131] Table 8 below indicates the mass ratio of the raw material used in this example to the sample of the composition used, hereinafter called INVENTION 350, which is the same as for example 2 and has the following composition:
TABLE-US-00009 TABLE 8 Example 8 9.3% Glucose 48% Glycerin 42.7% Propylene
[0132] 5. Methodology
[0133] 5.1 Cell Culture
[0134] In this study, human keratinocyte cells from the epidermis were used, maintained in culture with DMEM (Dulbecco's Modified Eagle's Medium) with the addition of supplements, in a stove at 37° C. and 5% CO.sub.2 and manipulated inside the hood of laminar flow. In passage O.sub.3 after thawing, the cells were distributed in 60 mm plates for the study.
[0135] 5.2 Sample Preparation
[0136] Sample NV.73.02
[0137] Sample preparation conditions in the starting solution: 10% of the sample in 90% of the culture medium;
[0138] Additional procedures for solubilization: additional solubilization at 10% in culture medium for the final solution of the study;
[0139] Aspect of the solubilized sample: fully solubilized.
[0140] Expected sample concentrations (%): 0.1%
[0141] Presence of additional solvent at the highest tested concentration of the sample: not applicable.
[0142] pH measurement at the highest tested concentration of the sample: not determined.
[0143] Sample NV.74.02
[0144] Sample preparation conditions in the starting solution: 10% of the sample in 90% of the culture medium;
[0145] Additional procedures for solubilization: additional solubilization at 10% in culture medium for the final solution of the study;
[0146] Aspect of the solubilized sample: fully solubilized.
[0147] Expected sample concentrations (%): 0.1%
[0148] Presence of additional solvent at the highest tested concentration of the sample: not applicable.
[0149] pH measurement at the highest tested concentration of the sample: not determined.
[0150] 5.3 Preparation of the Control Group
[0151] Control group: supplemented culture medium;
[0152] 5.4 Evaluation of Hydration-Related Marker by Reverse Transcriptase Reaction Followed by Real-Time Polymerase Chain Reaction (RTq-PCR).
[0153] The solutions containing the control groups and samples were applied to the keratinocyte cell culture followed by an incubation in a stoven at 37° C. and 5% CO.sub.2 for 24 hours. Afterwards, the extraction of messenger RNA with trizole was performed, evaluating its quantity and purity. From the messenger RNA, the reverse transcriptase reaction was performed to obtain the complementary strand of DNA. Then, analysis of aquaporin-3 was performed.
[0154] GAPDH was used as an endogenous control.
[0155] 5.5 Analysis of Results
[0156] The results were evaluated using Microsoft Excel software.
[0157] For the analysis of the data obtained by RTq-PCR, the analysis from the 2{circumflex over ( )}−ΔΔ Ct was used for graphic representation of the relative expression and statistical analysis from the ΔCt data. The control group was normalized to 1 and the other groups compared against it. Statistical analysis for comparison between groups was performed with T test and statistical significance level considered lower than 0.05.
[0158] 6. Results
[0159] Using the RTq-PCR technique, the relative expression of aquaporin 3 was compared between the control groups, sample NV.73.02 and NV.74.02.
[0160] 7. Conclusions
[0161] According to the results obtained, it is possible to state that:
[0162] Samples NV.73.02 and NV.74.02 increased the expression of aquaporin 3, which is related to increased hydration;
[0163] Comparing the samples evaluated, it was observed that the sample NV.74.02 showed a significant increase in the expression of aquaporin, this increase being greater when compared to the sample NV.73.02;
[0164] the attached
[0165] 8. OPINION
[0166] In the study entitled “IN VITRO HYDRATION STUDY” referring to the DIMETHICONE 350 AND INVENCÃO 350 products, codes NV.73.02 and NV.74.02, it can be concluded that:
[0167] The products DIMETHICONE 350 AND INVENTION 350, codes NV.73.02 and NV.74.02, increase hydration by increasing aquaporin expression.
[0168] 9. Notes
[0169] The results described herein are applicable only to the sample(s) tested, under the conditions and concentrations evaluated in this study.
[0170] The results presented are exclusively obtained from in vitro tests.