MEDICINE FOR TREATING PULMONARY MYCOSIS

Abstract

The application of the addition and subtraction of Er Chen Tang in the preparation of medicine or health care products for the treatment of pulmonary fungal diseases belongs to the medical and health care field, which specifically relates to the use of alkaloids and volatile oils contained in Pinellia ternate, Tangerine peel, Liquorice, Coix seed, Gastrodia elata in the preparation of medicine or health care products for the treatment of pulmonary fungal diseases.

Claims

1. A medicine for treating pulmonary mycosis, characterized in that the raw materials for the medicine include alkaloids and/or volatile oils extracted from Pinellia ternata, alkaloids and/or volatile oils extracted from Tangerine peel, alkaloids and/or volatile oils extracted from Liquorice, alkaloids and/or volatile oils extracted from Coix seed, alkaloids and/or volatile oils extracted from Gastrodia elata; the methods for preparing the medicine include: taking Pinellia ternata alkaloids, Tangerine peel alkaloids, Coix seed alkaloids, Liquorice alkaloids, and Gastrodia elata alkaloids, mixing them in a certain proportion, adding various conventional excipients required for preparing different dosage forms to them, and preparing pharmaceutically acceptable dosage forms; taking Pinellia ternate volatile oils, fresh Tangerine peel volatile oils, Liquorice volatile oils, Coix seed volatile oils, and Gastrodia elata volatile oils, mixing them in a certain proportion, adding various conventional excipients required for preparing different dosage forms to them, and preparing pharmaceutically acceptable dosage forms; taking Pinellia ternate alkaloids and volatile oils, Tangerine peel alkaloids and volatile oils, Liquorice alkaloids and volatile oils, Coix seed alkaloids and volatile oils, Gastrodia elata alkaloids and volatile oils, mixing the volatile oils in a proportion, including beta-cyclodextrin in them, mixing them with various dry alkaloid substances and suitable amounts of excipients, and preparing pharmaceutically acceptable dosage forms using conventional methods for preparing medicines.

2. The medicine according to claim 1, characterized in that the raw materials for the medicine can be further selected from: alkaloids and/or volatile oils extracted from Fritillaria cirrhosa, alkaloids and/or volatile oils extracted from Trichosanthes kirilowii, alkaloids and/or volatile oils extracted from Rhizoma arisaematis, alkaloids and/or volatile oils extracted from Sinapis alba, alkaloids and/or volatile oils extracted from Gleditsia sinensis, alkaloids and/or volatile oils extracted from Radix stemona, alkaloids and/or volatile oils extracted from Japanese ardisia, alkaloids and/or volatile oils extracted from Artichoke, alkaloids and/or volatile oils extracted from Bletilla striata, alkaloids and/or volatile oils extracted from Lotus root, alkaloids and/or volatile oils extracted from Aconitum carmichaeli, alkaloids and/or volatile oils extracted from Hovenia dulcis.

3. The medicine according to claim 1, characterized in that the weight parts of the alkaloids and/or volatile oils of the raw materials for the medicine are: 0.001-50 weight parts of the alkaloids and/or volatile oils extracted from Pinellia ternata, 0.001-50 weight parts of the alkaloids and/or volatile oils extracted from Tangerine peel, 0.001-50 weight parts of the alkaloids and/or volatile oils extracted from Coix seed, 0.001-50 weight parts of the alkaloids and/or volatile oils extracted from Liquorice, 0.001-50 weight parts of the alkaloids and/or volatile oils extracted from Gastrodia elata, 0-50 weight parts of the alkaloids and/or volatile oils extracted from Fritillaria cirrhosa, 0-50 weight parts of the alkaloids and/or volatile oils extracted from Trichosanthes kirilowii, 0-50 weight parts of the alkaloids and/or volatile oils extracted from Rhizoma arisaematis, 0-50 weight parts of the alkaloids and/or volatile oils extracted from Sinapis alba, 0-50 weight parts of the alkaloids and/or volatile oils extracted from Gleditsia sinensis, 0-50 weight parts of the alkaloids and/or volatile oils extracted from Radix stemona, 0-50 weight parts of the alkaloids and/or volatile oils extracted from Japanese ardisia, 0-50 weight parts of the alkaloids and/or volatile oils extracted from Artichoke, 0-50 weight parts of the alkaloids and/or volatile oils extracted from Bletilla striata, 0-50 weight parts of the alkaloids and/or volatile oils extracted from Lotus root, 0-50 weight parts of the alkaloids and/or volatile oils extracted from Aconitum carmichaeli, 0-50 weight parts of the alkaloids and/or volatile oils extracted from Hovenia dulcis.

4. The medicine according to claim 1, characterized in that the methods for preparing the medicine include: according to the weight parts of the selected raw materials, extracting alkaloids from Pinellia ternata, Tangerine peel, Liquorice, Coix seed, Gastrodia elata or Fritillaria cirrhosa or Trichosanthes kirilowii or Rhizoma arisaematis or Sinapis alba or Gleditsia sinensis or Radix stemona or Japanese ardisia or Artichoke or Bletilla striata or Lotus root or Aconitum carmichaeli or Hovenia dulcis, respectively, using modern extraction technology, such as, but not limited to, cold immersion, percolation, supercritical fluid extraction, membrane separation, ultrasonic extraction, Soxhlet extraction method; mixing the respective alkaloids, and adding conventional excipients to them; preparing pharmaceutically acceptable dosage forms, such as, but not limited to, tablets, powder injections and capsules, according to conventional processes for preparing medicines.

5. The medicine according to claim 1, characterized in that the methods for preparing the medicine include: according to the weight parts of the selected raw materials, extracting volatile oils from Pinellia ternata, Tangerine peel, Liquorice, Coix seed, Gastrodia elata or Fritillaria cirrhosa or Trichosanthes kirilowii or Rhizoma arisaematis or Sinapis alba or Gleditsia sinensis or Radix stemona or Japanese ardisia or Artichoke or Bletilla striata or Lotus root or Aconitum carmichaeli or Hovenia dulcis, respectively, using modern extraction technology, such as, but not limited to, supercritical fluid extraction, organic solvent extraction, steam distillation and cold pressing method; mixing various volatile oils in a proportion and adding various conventional excipients required for preparing different dosage forms to them; preparing pharmaceutically acceptable dosage forms, such as, but not limited to, tablets, soft capsules, topical liniment, and granules, according to conventional processes for preparing medicines.

6. The medicine according to claim 1, characterized in that the methods for preparing the medicine include: according to the weight parts of the selected raw materials, extracting alkaloids and volatile oils from Pinellia ternata, Tangerine peel, Liquorice, Coix seed, Gastrodia elata or Fritillaria cirrhosa or Trichosanthes kirilowii or Rhizoma arisaematis or Sinapis alba or Gleditsia sinensis or Radix stemona or Japanese ardisia or Artichoke or Bletilla striata or Lotus root or Aconitum carmichaeli or Hovenia dulcis, respectively, using modern extraction technology, such as, but not limited to, supercritical fluid extraction, membrane separation, organic solvent extraction, steam distillation, cold pressing method; mixing the various volatile oils in a proportion, including beta-cyclodextrin in them, mixing them with various dry alkaloid substances and suitable amounts of excipients, adding various conventional excipients required for preparing different dosage forms to them; preparing pharmaceutically acceptable dosage forms, such as, but not limited to, tablets and granules, according to conventional processes for preparing medicines.

7. The medicine according to claim 1, characterized in that the scope of application of the medicine includes application in medical medicine, health food, health products, animal medicine, and animal feed.

Description

SPECIFIC IMPLEMENTATION MODE

Example 1

[0047] The composition of the medicine for the treatment of pulmonary mycosis in the embodiment is as follows: alkaloids and volatile oils contained in 80 g fresh Pinellia ternata, alkaloids and volatile oils contained in 50 g fresh Tangerine peel, alkaloids and volatile oils contained in 100 g fresh Coix seed, alkaloids and volatile oils contained in 50 g fresh Liquorice, alkaloids and volatile oils contained in 80 g fresh Gastrodia elata.

[0048] According to the weight of selected raw materials, the alkaloids of Pinellia ternate, Tangerine peel, Liquorice, Coix seed and Gastrodia elata were extracted by supercritical fluid extraction or membrane separation method respectively. The alkaloids were mixed and added with conventional excipients. The tablets or powder injections and other pharmaceutically acceptable dosage forms were prepared according to the conventional preparation process.

[0049] According to the weight of selected raw materials, the volatile oils were extracted from Pinellia, Tangerine peel, Liquorice, Coix seed and Gastrodia elata by supercritical fluid extraction, organic solvent extraction or steam distillation, respectively. The volatile oils were mixed and added with conventional excipients to prepare soft capsules or granules and other pharmaceutically acceptable dosage forms.

[0050] According to the weight of the selected raw materials, the alkaloids and volatile oils were extracted from Pinellia ternate, Tangerine peel, Liquorice, Coix seed and Gastrodia elata by supercritical fluid extraction, organic solvent extraction or steam distillation, respectively. The volatile oils were mixed in proportion and then mixed with various alkaloids and appropriate excipients after inclusion by beta cyclodextrin It can be made into tablets, granules and other pharmaceutically acceptable dosage forms.

Example 2

[0051] The composition of the medicine for treating pulmonary aspergillosis in the embodiment is as follows: alkaloids and volatile oils in 60 g fresh Pinellia ternata, alkaloids and volatile oils in 100 g fresh Gastrodia elata, alkaloids and volatile oils in 40 g fresh Tangerine peel, alkaloids and volatile oils in 40 g fresh Liquorice, alkaloids and volatile oils in 120 g fresh Coix seed, alkaloids and volatile oils in 60 g fresh Stemona, alkaloids and volatile oils in 100 g fresh Trichosanthes kirilowii, alkaloids and volatile oils in 50 g fresh Fritillaria cirrhosa, alkaloids and volatile oils in 80 g fresh Bletilla striata.

[0052] According to the weight of selected raw materials, the alkaloids of Pinellia ternate, Tangerine peel, Liquorice, Coix seed, Gastrodia elata, Stemona, Trichosanthes kirilowii, Fritillaria cirrhosa and Bletilla striata were extracted by supercritical fluid extraction or membrane separation method respectively. The alkaloids were mixed and added with conventional excipients, and the pharmaceutically acceptable dosage forms such as tablets or powder injections were made according to the normal preparation process.

[0053] According to the weight of selected raw materials, the volatile oils were extracted from Pinellia ternata, Tangerine peel, Liquorice, Coix seed, Gastrodia elata, Stemona, Trichosanthes kirilowii, Fritillaria cirrhosa and Bletilla striata by supercritical fluid extraction, organic solvent extraction or steam distillation, respectively. Then the volatile oils were mixed with conventional excipients and made into soft capsules or granules according to the conventional preparation process Acceptable dosage form.

[0054] According to the weight of the selected raw materials, the alkaloids and volatile oils were extracted from Pinellia ternata, Tangerine, Coix seed, Liquorice, Gastrodia elata, Stemona, Trichosanthes kirilowii, Fritillaria cirrhosa and Bletilla striata respectively by supercritical fluid extraction, organic solvent extraction or steam distillation. The volatile oils were mixed in proportion and then mixed with various alkaloids and appropriate excipients after inclusion by beta cyclodextrin The tablets, granules and other pharmaceutically acceptable dosage forms were prepared by conventional method.

Example 3

[0055] The composition of the medicine for treating pulmonary candidiasis in the embodiment is as follows: alkaloids and volatile oils in 100 g fresh Pinellia ternata, alkaloids and volatile oils in 80 g fresh Tangerine peel, alkaloids and volatile oils in 50 g fresh Liquorice, alkaloids and volatile oils in 60 g fresh Coix seed, alkaloids and volatile oils in 100 g fresh Gastrodia elata, alkaloids and volatile oils in 60 g fresh Rhizoma Arisaematis, alkaloids and volatile oils in 100 g fresh Sinapis alba.

[0056] According to the weight of the selected raw materials, the alkaloids of Pinellia ternate, Tangerine peel, Coix seed, Liquorice, Gastrodia elata, Rhizoma Arisaematis and Sinapis alba were extracted by supercritical fluid extraction or membrane separation method respectively. The alkaloids were mixed and added into the conventional excipients, and the pharmaceutically acceptable dosage forms such as tablets or powder injections were made according to the conventional preparation process.

[0057] According to the weight of the selected raw materials, the volatile oils were extracted from Pinellia ternata, Tangerine peel, Coix seed, Liquorice, Gastrodia elata, Arisaema and Sinapis alba by supercritical fluid extraction, organic solvent or steam distillation, respectively. Then the volatile oils were mixed and added with conventional excipients to prepare soft capsules or granules Type.

[0058] According to the weight of the selected raw materials, the alkaloids and volatile oils were extracted from Pinellia ternate, Tangerine peel, Coix seed, Liquorice, Gastrodia elata, Arisaema and Sinapis alba by supercritical fluid extraction, organic solvent extraction or steam distillation, respectively. The volatile oils were mixed in proportion, then were inclusion by beta cyclodextrin, and then mixed with various alkaloids dry matter and appropriate accessories The preparation method of the drug is to prepare tablets, granules and other pharmaceutically acceptable dosage forms.

Example 4

[0059] The composition of the medicine for treating pulmonary mycosis in case of blood in sputum or hemoptysis in the embodiment is as follows: alkaloids and volatile oils in 70 g fresh Pinellia ternata, alkaloids and volatile oils in 50 g fresh Tangerine peel, alkaloids and volatile oils in 50 g fresh Liquorice, alkaloids and volatile oils in 150 g fresh Coix seed, alkaloids and volatile oils in 100 g fresh Gastrodia elata, alkaloids and volatile oils in 120 g fresh Trichosanthes kirilowii, alkaloids and volatile oils in 150 g fresh Lotus root, alkaloids and volatile oils in 100 g fresh Artichoke, alkaloids and volatile oils in 100 g fresh Bletilla striata.

[0060] According to the weight of the selected raw materials, the alkaloids were extracted from Pinellia ternate, Tangerine peel, Coix seed, Liquorice, Gastrodia elata, Trichosanthes kirilowii, Lotus root, Artichoke and Bletillae striata respectively by supercritical fluid extraction or membrane separation method. The alkaloids were mixed and added with conventional excipients to prepare tablets or powder injections and other pharmaceutically acceptable dosage forms.

[0061] According to the weight of selected raw materials, the volatile oils were extracted from Pinellia ternata, Tangerine peel, Coix seed, Liquorice, Gastrodia elata, Trichosanthes kirilowii, Lotus root, Artichoke and Bletilla striata by supercritical fluid extraction, organic solvent extraction or steam distillation, respectively. Then the volatile oils were mixed with conventional excipients and made into soft capsules or granules according to the conventional preparation process The dosage form affected.

[0062] According to the weight of the selected raw materials, the alkaloids and volatile oils were extracted from Pinellia ternate, Tangerine peel, Coix seed, Liquorice, Gastrodia elata, Trichosanthes kirilowii, Lotus root, Artichoke and Bletilla striata by supercritical fluid extraction, organic solvent extraction or steam distillation, respectively The tablets, granules and other pharmaceutically acceptable dosage forms were prepared by the conventional method.

Example 5

[0063] The composition of the medicine for treating pulmonary cryptococcosis in the embodiment is as follows: alkaloids and volatile oils in 100 g of fresh Pinellia ternata, alkaloids and volatile oils in 50 g of fresh Tangerine peel, alkaloids and volatile oils in 50 g of fresh Liquorice, alkaloids and volatile oils in 120 g of fresh Coix seed, alkaloids and volatile oils in 100 g of fresh Gastrodia elata, alkaloids and volatile oils in 100 g of fresh Rhizoma Arisaematis, alkaloids and volatile oils in 150 g fresh Trichosanthes kirilowii.

[0064] According to the weight of the selected raw materials, the alkaloids were extracted from Pinellia ternate, Tangerine peel, Coix seed, Liquorice, Gastrodia elata, Rhizoma Arisaematis and Trichosanthes kirilowii respectively by supercritical fluid extraction or membrane separation method. The alkaloids were mixed, added with conventional auxiliary materials, and the pharmaceutical acceptable formulations such as tablet or powder injection were made according to the conventional preparation process.

[0065] According to the weight of selected raw materials, the volatile oils were extracted from Pinellia ternate, Tangerine peel, Coix seed, Liquorice, Gastrodia elata, Rhizoma Arisaematis and Trichosanthes kirilowii respectively by supercritical fluid extraction or organic solvent extraction method. the volatile oils were mixed, and the conventional auxiliary materials were added. The pharmaceutical formulations such as soft capsules or granules were made according to the conventional preparation process.

[0066] According to the weight of the selected raw materials, the alkaloids and volatile oils were extracted from Pinellia ternata, Tangerine peel, Coix seed, Liquorice, Gastrodia elata, Rhizoma Arisaematis and Trichosanthes kirilowii respectively by supercritical fluid extraction or organic solvent extraction or steam distillation. The volatile oils were mixed with various alkaloids and some auxiliary materials after inclusion with betamethasin in proportion, and then mixed with various alkaloid dryers and proper accessories The method of preparing medicine is to make the pharmaceutically acceptable dosage forms such as tablet and granule.

Example 6

[0067] The composition of the medicine for treating pulmonary obstructive fungal disease in the embodiment is as follows: alkaloids and volatile oils in 100 g of Pinellia ternata, alkaloids and volatile oils in 100 g of Tangerine peel, alkaloids and volatile oils in 60 g of fresh Liquorice, alkaloids and volatile oils in 150 g of fresh Coix seed, alkaloids and volatile oils in 100 g of fresh Gastrodia elata, alkaloids and volatile oils in 100 g of fresh Radix Stemonae, alkaloids and volatile oils in 120 g of Japanese ardisia, alkaloids and volatile oils in 100 g of fresh Lotus root.

[0068] The alkaloids were extracted from Pinellia ternata, Tangerine peel, Coix seed, Liquorice, Gastrodia elata, Radix Stemonae, Japanese ardisia and Lotus root joint by supercritical fluid extraction or membrane separation according to the weight of the selected raw materials. The alkaloids were mixed, added with conventional auxiliary materials, and the pharmaceutical acceptable formulations such as tablets or powder injection were made according to the conventional preparation process.

[0069] The volatile oils were extracted from Pinellia ternata, Tangerine peel, Coix seed, Liquorice, Gastrodia elata, Radix Stemonae, Japanese ardisia and Lotus root joint by supercritical fluid extraction or organic solvent extraction or steam distillation according to the weight of selected raw materials. Then, the volatile oil was mixed with the volatile oil, and the conventional preparation of drugs was used to make soft capsules or granules The dosage form of.

[0070] The alkaloids and volatile oils of the raw materials were extracted from Pinellia ternata, Tangerine peel, Coix seed, Liquorice, Gastrodia elata, Radix Stemonae, Japanese ardisia and Lotus root joint by supercritical fluid extraction or organic solvent extraction or steam distillation according to the weight of selected raw materials. The volatile oils were mixed with various alkaloids dry and proper auxiliary materials after inclusion with betacyclin, so as to The conventional method of preparing drugs can be used to make the pharmaceutically acceptable formulations such as tablets and granules.

Example 7

[0071] The composition of the medicine for treating pulmonary mycosis in the case of pulmonary edema and pleural effusion in the embodiment is as follows: alkaloids and volatile oils in 120 g fresh Pinellia ternata, alkaloids and volatile oils in 80 g fresh Tangerine peel, alkaloids and volatile oils in 80 g fresh Liquorice, alkaloids and volatile oils in 200 g fresh Coix seed, alkaloids and volatile oils in 150 g fresh Gastrodia elata, alkaloids and volatile oils in 100 g fresh Japanese ardisia, alkaloids and volatile oils in 100 g fresh Rhizoma Arisaematis, alkaloids and volatile oils in 80 g fresh Aconitum carmichaeli and alkaloids and volatile oils in 100 g fresh Hovenia dulcis.

[0072] According to the weight of the selected raw materials, the alkaloids were extracted from Pinellia ternate, Tangerine peel, Coix seed, Liquorice, Gastrodia elata, Japanese ardisia, Rhizoma Arisaematis, Aconitum carmichaeli and Hovenia dulcis by supercritical fluid extraction or membrane separation method. The alkaloids were mixed and added with conventional excipients to prepare tablets or powder injections according to the conventional preparation process.

[0073] According to the weight of selected raw materials, supercritical fluid extraction or organic solvent extraction method was used to extract the volatile oils from Pinellia ternata, Tangerine peel, Coix seed, Liquorice, Gastrodia elata, Japanese ardisia, Rhizoma Arisaematis, Aconitum carmichaeli and Hovenia dulcis. Then the volatile oil was mixed and added with conventional excipients. According to the conventional preparation process, the pharmaceutically acceptable dosage forms such as soft capsules or granules were made.

[0074] According to the weight of the selected raw materials, the alkaloids and volatile oils were extracted from Pinellia ternata, Tangerine peel, Coix seed, Liquorice, Gastrodia elata, Japanese ardisia, Rhizoma Arisaematis, Aconitum carmichaeli and Hovenia dulcis by supercritical fluid extraction, organic solvent extraction or steam distillation, respectively. The volatile oils were mixed in proportion, and then mixed with various alkaloids and appropriate amount of auxiliary substances after inclusion with beta cyclodextrin The mixture is made into tablets, granules and other pharmaceutically acceptable dosage forms by the conventional method of drug preparation.

[0075] Of course, the above embodiments are only for the purpose of clearly illustrating the examples given, rather than limiting the embodiments. For those skilled in the art, other changes or changes in different forms can be made on the basis of the above description. It is unnecessary and impossible to enumerate all the embodiments here, and the obvious changes or variations thus extended are still within the protection scope of the present invention.

[0076] Inventiveness and Novelty of the Invention

[0077] The creative idea of the invention starts from the research of headache case by Zhang Yuansu, a famous doctor of Jin Dynasty, thus cracking the theory of Yin Yang and five elements of ancient Chinese traditional culture. For the details of the decoding content of the theory of Yin Yang and five elements, please refer to my other application 201410299118.9 “a broad-spectrum anti anaerobic drug composition”, which introduces in detail the relationship between the theory of Yin Yang and five elements and modern medicine. The theory of Yin Yang and five elements is the basis of all the social theories in ancient China and the theory of traditional Chinese medicine. There are different interpretations of the theory of Yin Yang and five elements by Chinese physicians in the past dynasties. The mainstream view is that the initial formation of the theory of Yin Yang is related to the sun and the moon, and extends from the characteristics of “facing the sun” and “backing the sun” to all things. Traditional Chinese medicine believes that man is an organic whole composed of yin and Yang, and the fundamental mechanism of the occurrence, development and change of diseases lies in the imbalance of yin and Yang. Therefore, the basic principle of treating diseases is to adjust Yin and Yang, supplement its deficiency, reduce its excess, and restore the balance and coordination of yin and Yang in the body. Three yin and three yang are the basic forms of yin-yang theory of traditional Chinese medicine, but the relationship between yin-yang theory and modern medicine has not been clear in the field of traditional Chinese medicine. The mainstream view of traditional Chinese medicine is that the theory of Yin-Yang and five elements is not related to the theory of modern Western Medicine.

[0078] In traditional Chinese medicine, the bacteria living in the “Yin Meridian” are called “Yin evil”, which can be divided into “damp evil” and “cold evil”. Combined with modern medical knowledge, I believe that “Yin Qi” in traditional Chinese medicine refers to carbon dioxide, “Yang Qi” refers to oxygen. In traditional Chinese medicine, “Yin Meridian” refers to vein, “Yang Meridian” refers to artery. “Dampness evil” in “Yin Meridian” refers to various bacteria (such as fungi, anaerobes, bacilli, viruses, etc.) that survive in vein or mucus and are tolerant to hypoxia, while “cold evil” refers to mold. And because mold is a fungus, its vitality is very strong, and its tolerance to hypoxia is the strongest among all bacteria. Just like the principle of fermentation, all kinds of bacteria coexist at the beginning, but only mold survives after fermentation failure. Therefore, in the race against time, all kinds of hypoxia resistant bacteria can survive in the vein. Only mold has the strongest vitality and destructive power. Canceration is the process of fungi from quantitative change to qualitative change. The clinical symptoms reflected in the quantitative change process are the symptoms of various chronic diseases. When the symptoms of cancer appear, only fungi are dominant in the body. Therefore, I think fungi are the main pathogenic factors of cancer, and fungi are also the main pathogenic factors of various chronic diseases.

[0079] Therefore, I come to the conclusion that “Hua Shi medicine, Qu Han medicine” has antifungal effect. Inspired by the characteristics of acidophilic and alkalophilic fungi, I concluded that alkaloids contained in plant APIs are antifungal chemical components. Inspired by the traditional Chinese medicine “aromatizing dampness, pungent dampness, warm cold”, I concluded that volatile oil contained in plant APIs is also antifungal chemical components.

[0080] According to the theory of five elements, ancient scholars believe that wood, fire, earth, gold and water are the five basic substances that make up the whole world. This theory later infiltrated into traditional Chinese medicine, and combined with Yin-yang theory to become the basis of traditional Chinese medicine.

[0081] The characteristics of the five elements are: Wood—Qu Zhi, fire—Yan Shang, earth—farming, gold—Cong Ge, water—Run Xia. It is generally believed in the field of traditional Chinese medicine that although the characteristics of the five elements come from the specific observation of wood, fire, earth, metal and water, they are the result of the ancients' abstract description. They have gone beyond their own specific characteristics and have a broader rational meaning. Moreover, the traditional Chinese medicine circles have not been able to explain the characteristics of the five elements, especially the analysis of “farming” is far fetched.

[0082] Inspired by the word “Cang Jie”, I believe that “gold” is the anatomical figure of the lung, and “Wood” represents the whole body distribution map of twelve meridians, that is, the distribution map of blood vessels in the whole body, and the blood circulation path from foot to head and hand to head. “Earth” is the anatomical figure of liver, “water” is the anatomical figure of two kidneys and urinary system, “fire” is the anatomical figure of heart.

[0083] In traditional Chinese medicine, “mutual generation” refers to the fact that one of the five elements has the function of promoting, encouraging and supporting another. The law and order of the five elements are: wood makes fire, fire makes earth, earth makes gold, gold makes water and water makes wood. The so-called “mutual restraint” refers to the inhibition, restraint and weakening of one thing to another. The law and order of the five elements are: metal conquers wood, wood conquers earth, earth conquers water, water conquers fire and fire conquers gold. The application of the theory of five elements in traditional Chinese medicine is mainly to analyze and summarize the internal relations among the physiological functions of Jin Ke Mu, Mu Ke Tu, Tu Ke Shui, Shui Ke Huo and Huo Ke Jin by using the theory of five elements. In traditional Chinese medicine circles, it is believed that the pathological changes of one organ can affect other organs through different ways, and this organ itself may also be affected by the pathological changes of other organs. However, it has not been clear how they affect each other, nor has it been clear about the pathological mechanism of the five elements restraining each other.

[0084] My research on “wood-Mu” and “Earth-Tu” shows that “wood” does not represent the liver, but represents the whole body distribution map of twelve meridians, that is, the blood circulation path from foot to head and hand to head. In my opinion, “Earth” does not represent the spleen, but refers to the liver, “Earth” is the pictograph of the liver.

[0085] The relationship between the five elements indicates the process of pathological changes caused by pathogenic bacteria. Therefore, I think Jin ke Mu means: after the bacteria infect the lungs through the respiratory tract, they enter the blood circulation system of the whole body and stay in the capillary ends of hands, feet and heads. Especially in the upper respiratory tract, bacteria are easy to enter the brain capillaries. Fungi propagate continuously in the brain capillaries, blocking the veins and arteries of the brain. First, the clinical symptoms appear in the eyes, and then insomnia, mental disorders, hypertension and other symptoms.

[0086] Mu ke Tu means: bacteria in the blood stay at the end of capillaries of hands, feet and heads, continue to propagate and transfer, and stay in the liver to propagate, causing substantial pathological changes in the liver. Because the blood vessels of the liver are very rich, especially the hepatic portal vein group is easy to retain bacteria.

[0087] Tu ke Shui means: after invading the liver, the next pathogen causing pathological changes is the kidney. Because the blood vessels of the kidney are also very rich, normal people have 1000 ml blood flow through both kidneys every minute, glomerular capillaries are easy to retain bacteria, causing renal artery stenosis, mainly manifested as hypertension, renal vein thrombosis can appear a lot of proteinuria.

[0088] Shui ke Huo means: after the substantial pathological changes in the kidney, it is the turn for the heart to have substantial pathological changes.

[0089] Huo ke Jin: when there are pathological changes in the heart, the last thing is that there are substantial lesions in the lungs. This is because the lung is an open organ, with the most abundant oxygen content inside. Only when the number of fungi reaches a certain level and many blood vessels are blocked, can substantial lesions appear in the lung. At this time, the patient's systemic symptoms are obvious, which also indicates that the patient often dies of respiratory failure in the end.

[0090] Modern studies have found that the spores of fungi propagate by budding and form hyphae, which interweave into clusters. When the germinated spores grow to a certain size, they are separated from the mother. I think fungi are the same as human beings. When children grow up, they have to go out separately. Therefore, the fungi that fall off from the mother look for the suitable place for foot drop with the blood circulation everywhere, and the acupoints on the twelve meridians are the natural place for retention and reproduction.

[0091] Therefore, I think: the process of fungal pathological transfer is affected by non external factors, and the process of pathological transfer is: respiratory tract infection (entering from artery).fwdarw.systemic blood circulation (end of capillaries in head, hand and foot).fwdarw.hepatic vein and artery.fwdarw.renal vein and artery.fwdarw.cardiac vein and artery.fwdarw.pulmonary vein and artery.

[0092] Of course, trauma, surgery, transplantation and other external factors will lead to changes in the process of fungal pathological metastasis. Moreover, fungi are easy to stay and reproduce in the injured part, because the blood circulation of the injured part is blocked.

[0093] The medicine provided by the invention is innovated on the basis of Er Chen Tang. The medicine provided by the invention is made by mixing the alkaloids and/or volatile oils contained in Pinellia ternata, Tangerine feel, Liquorice, Coix seed, Gastrodia elata and other plant medicines on the basis of Pinellia ternata, tangerine peel, Liquorice, Coix seed, Gastrodia elata.

[0094] The inventiveness of the medicine provided by the invention is embodied in that the raw material medicine is composed of Pinellia alkaloids, Tangerine peel alkaloids, Liquorice alkaloids, Coix seed alkaloids, Gastrodia elata alkaloids, etc., instead of pinellia, Tangerine peel, Liquorice, Coix seed, Gastrodia elata and other natural herbs. The alkaloids extracted from Pinellia ternate, Tangerine, Liquorice, Coix seed and Gastrodia elata were mixed in proportion, and the conventional excipients were added to make the clinically acceptable dosage form according to the conventional preparation process.

[0095] Compared with the existing chemical drugs which are made from single plant alkaloids, the drug provided by the invention can reduce the content of single alkaloid in the drug, reduce the toxic reaction caused by excessive dosage of single alkaloid, and improve the drug resistance. For example, morphine obtained from opium has a strong analgesic effect, because it is a single alkaloid, in order to achieve the curative effect, its dosage is too large and prone to toxic and side effects. Moreover, the medicine provided by the invention can more effectively target the vascular tissues in different parts due to the synergistic effect of multiple alkaloids, and has more drug resistance.

[0096] Compared with the traditional Chinese medicine made by the modern pharmaceutical method, the medicine provided by the invention also has significant progress. Because traditional Chinese medicine is not necessarily all herbal medicine, but also animal and mineral, the most important feature of modern traditional Chinese medicine is that it is unable to know all the ingredients, but only the main ingredients, that is, the chemical ingredients that can cure diseases. The chemical ingredients of the medicine provided by the invention are only various alkaloids and volatile oils, and the chemical ingredients are clear.

[0097] Moreover, the pharmacological mechanism of the existing Chinese patent medicine is not clear, and the pharmaceutical pharmacological mechanism provided by the invention is clear. The pharmacological mechanism is that the alkaloids of each API have antifungal effect, and the volatile oil of each API has antifungal effect. Moreover, different alkaloids and volatile oils have their own characteristics, which can target different blood vessels, tissues and cells. Therefore, the combination of alkaloids and/or volatile oil can play a team role. The effectiveness of alkaloids and volatile oil can be significantly improved by cooperation and division of labor.

Technical Effect

[0098] The traditional Er Chen Tang has been clinically proved to be safe and effective. The applicant treated an elderly patient with pulmonary aspergillosis by traditional Chinese medicine decoction with raw materials such as Pinellia ternata, Tangerine peel, Liquorice, Coix seed and Gastrodia elata. After 7 days, the symptoms were significantly improved. The patient was chronic bronchitis, long-term cough, sputum with blood, common anti-inflammatory treatment failed repeatedly, suspected of fungal infection, sputum smear found Aspergillus hyphae. The medicine provided by the invention is based on the raw material medicine of the traditional classical prescription Er Chen Tang, and extracts the volatile oils and alkaloids contained in the plant medicine Pinellia ternate, Tangerine peel, Liquorice, Coix seed, Gastrodia elata to prepare the medicine or health care product for treating pulmonary fungal disease. Because the chemical composition of the medicine or health care product provided by the invention is clear and the pharmacological action is clear, the effectiveness is obvious compared with the traditional pharmaceutical method. Because the applicant has no conditions to extract alkaloids and volatile oils from the API for test, however, based on the contents recorded in the description and the common technical knowledge in the art, those skilled in the art can implement the technical scheme of the invention, solve the technical problems and produce the expected technical effect.