Filling Unit to Fill a Container, in Particular a Cartridge, With a Liquid Product of the Pharmaceutical Industry

Abstract

A filling unit to fill a container, in particular a cartridge, with a liquid product of the pharmaceutical industry having: a dosing head, which is arranged in a filling station and is designed to feed a quantity of product into the container through an open upper end of the container; a capping device, which is arranged in a capping station and is designed to insert a closing element into the container and through the open upper end of the container; and a sucking device which is arranged in a degasification station located between the filling station and the capping station, is designed to engage the open upper end of the container in a sealing manner, and is designed to generate a depression inside the container in an upper volume, which is not occupied by the product.

Claims

1. A filling unit (11) to fill a container (1) with a liquid product (5) of the pharmaceutical industry; the filling unit (11) comprising: a dosing head (12), which is arranged in a filling station (S1) and is designed to feed a quantity of product (5) into the container (1) through an open upper end of the container (1); a capping device (18), which is arranged in a capping station (S3) and is designed to insert a closing element into the container (1) and through the open upper end of the container (1); and a first sucking device (15), which is arranged in a degasification station (S2) located between the filling station (S1) and the capping station (S3), is designed to engage the open upper end of the container (1) in a sealing manner, and is designed to generate a depression inside the container (1) in an upper volume, which is not occupied by the product (5).

2. The filling unit (11) according to claim 1, wherein the first sucking device (15) is designed to generate a depression inside the container (1) in the upper volume, which is not occupied by the product (5), by sucking only and exclusively air.

3. The filling unit (11) according to claim 2, wherein the first sucking device (15) is designed to generate a depression inside the container (1) in the upper volume, which is not occupied by the product (5), by sucking only and exclusively air and therefore without sucking any part of the product (5) or any foam that is generated during the feeding of the product (5).

4. The filling unit (11) according to claim 1, wherein the first sucking device (15) is designed to generate a depression sufficient to suck part of the air but completely insufficient to suck any part of the product (5) or any foam that is generated during the feeding of the product (5).

5. The filling unit (11) according to claim 1, wherein the first sucking device (15) is designed to generate a depression inside the container (1) ranging from 1,000 to 10,000 Pascal and is designed to maintain the depression for an amount of time ranging from 0.4 to 3 seconds.

6. The filling unit (11) according to claim 1, wherein the first sucking device (15) comprises a first elastic cap (16), which is designed to engage the open upper end of the container (1).

7. The filling unit (11) according to claim 1 and comprising a second sucking device (20), which is arranged in the capping station (S3), is designed to engage the open upper end of the container (1) in a sealing manner, and is designed to generate a depression inside the container (1) in an upper volume, which is not occupied by the product (5), during the insertion of the closing element.

8. The filling unit (11) according to claim 7, wherein the second sucking device (20) is designed to generate a depression inside the container (1) in the upper volume, which is not occupied by the product (5), by sucking only and exclusively air.

9. The filling unit (11) according to claim 8, wherein the second sucking device (20) is designed to generate a depression inside the container (1) in the upper volume, which is not occupied by the product (5), by sucking only and exclusively air and therefore without sucking any part of the product (5) or any foam that is generated during the feeding of the product (5).

10. The filling unit (11) according to claim 7, wherein the second sucking device (20) is designed to generate a depression sufficient to suck part of the air but completely insufficient to suck any part of the product (5) or any foam that is generated during the feeding of the product (5).

11. The filling unit (11) according to claim 7, wherein the second sucking device (20) comprises a chamber (21), inside which the depression is generated and along which the closing element is caused to pass.

12. The filling unit (11) according to claim 7, wherein the second sucking device (20) is designed to generate a depression inside the container (1) ranging from 1,000 to 10,000 Pascal and is designed to maintain the depression for an amount of time ranging from 0.2 to 2 seconds.

13. The filling unit (11) according to claim 7, wherein the second sucking device (20) comprises a second elastic cap (22) which is designed to engage the open upper end of the container (1).

14. The filling unit (11) according to claim 7, wherein between the degasification station (S2) and the capping station (S3) there is a rest station (S4), in which the end of the container (1) is free and in communication with the external environment.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0012] The present invention will now be described with reference to the attached drawings, which illustrate a non-limiting example of embodiment, wherein:

[0013] FIG. 1 is a perspective view of a container, in particular a cartridge, for liquid products;

[0014] FIG. 2 is a side and partially sectioned view of the cartridge of FIG. 1; and

[0015] FIG. 3 is a schematic view of a filling unit of the cartridge of FIG. 1.

PREFERRED EMBODIMENTS OF THE INVENTION

[0016] In FIGS. 1 and 2, number 1 denotes as a whole a disposable container, specifically a cartridge (Carpule®) of the pharmaceutical industry. In the following, specific reference will be made to this type of container, without the invention losing its generality, as it can be advantageously applied to other containers for liquids of the pharmaceutical industry, for example syringes.

[0017] The cartridge 1 comprises a tubular body 2 closed at the front by a sealed cap 3 which can be centrally pierced (i.e. can be crossed through with relative ease by a needle) and closed at the rear by a piston 4 which acts as a rear cap and in use is designed to slide along the tubular body 2 to push a liquid product 5 outwards.

[0018] In FIG. 3, number 6 denotes a portion of a filling machine for filling a cartridge 1 of the type illustrated in FIG. 1.

[0019] The filling machine 6 comprises a feeding conveyor 7 which is designed to feed a group of cartridges 1 through a filling station S1 in which a quantity of liquid product 5 is fed inside each cartridge 1, through a subsequent degasification station S2, and finally through a capping station S3 in which a corresponding piston 4 (which acts as a rear cap) is inserted inside each cartridge 1.

[0020] According to a possible embodiment, the feeding conveyor 7 comprises (at least) a transport base 8 having a plurality of pockets 9, each of which is designed to house a corresponding cartridge 1 arranged “upside down” (i.e. with the bottom, still open facing upwards and with the cap 3 facing downwards); for example, each transport base 8 can have 15-30 pockets 9 oriented to form an array (i.e. on multiple rows and on multiple columns). Furthermore, the feeding conveyor 7 comprises a feeding device 10 which is designed to feed the transport base 8 through the stations S1, S2 and S3 with a step law of motion (i.e. a law of motion which cyclically alternates stopping and movement steps).

[0021] A filling unit 11 is arranged at the stations S1, S2 and S3 which carries out, among other things, the filling (in the filling station S1) and the capping (in the capping station S3) operations.

[0022] The filling unit 11 comprises a dosing head 12 which is arranged in the filling station S1 and is designed to feed a quantity of liquid product 5 inside each cartridge 1 which is located in the filling station S1. In particular, the dosing head 12 comprises a row of cannulas 13 (only one of which is illustrated in FIG. 3) which are inserted into respective cartridges 1 through the open upper ends of the cartridges 1 and deliver respective quantities of liquid product 5. Each cannula 13 is vertically movable and receives the liquid product 5 from a calibrated dosing device 14 arranged above the cannula 13.

[0023] The filling unit 11 comprises a sucking device 15 which is arranged in the degasification station S2 (which is located between the filling station S1 and the capping station S3), is designed to engage the open upper end of each cartridge in a sealing manner, which is located in the degasification station S2, and is designed to generate a depression inside each cartridge 1 in an upper volume not occupied by the liquid product 5. In particular, the sucking device 15 is designed to generate a depression inside each cartridge 1 in an upper volume, which is not occupied by the liquid product 5, by sucking only and exclusively air, i.e. without sucking any part of the liquid product 5 or any foam which is generated during the feeding of the liquid product 5; this result is obtained by causing the sucking device 15 to generate a depression sufficient to suck part of the air but completely insufficient to suck any part of the liquid product 5 or any foam that is generated during the feeding of the liquid product 5.

[0024] According to a possible embodiment, the sucking device 15 is designed to generate a depression inside each cartridge 1 ranging from 1,000 to 10,000 Pascals and is designed to maintain the depression for a time ranging from 0.4 to 3 seconds.

[0025] According to a possible embodiment illustrated in FIG. 3, the sucking device 15 comprises a plurality of elastic caps 16 (only one of which is illustrated in FIG. 3), each of which is designed to engage the open upper end of a corresponding cartridge 1 in a sealing manner. Each elastic cap 16 is connected by means of a flexible duct to a suction source 17 (typically a vacuum pump) which can be common for all elastic caps 16.

[0026] The filling unit 11 comprises a capping device 18 which is arranged in the capping station S3 and is designed to insert a piston 4 (i.e. a closing element) inside each cartridge 1 which is located in the capping station S3 and through the open upper end of the cartridge 1. Generally, the capping device 18 comprises a plurality of pushers 19 (only one of which is illustrated in FIG. 3) which are designed to force the pistons 4 (i.e. the closing elements) inside the corresponding cartridges 1 located in the capping station S3 and through the open upper ends of the cartridges 1. Generally, a compression element is coupled to each pusher 19 which has a funnel shape and elastically and radially compresses a corresponding piston 4 to make the piston 4 smaller and thus facilitate the entry of the piston 4 through the open upper end of a cartridge 1.

[0027] The filling unit 11 comprises a sucking device 20, which is arranged in the capping station S3, is designed to engage the open upper end of each cartridge 1 in a sealing manner, located in the capping station S3, and is designed to generate a depression inside each cartridge 1, in an upper volume not occupied by the liquid product 5, and during the insertion of the piston 4 (i.e. the closing element). In other words, simultaneously with the insertion of the piston 4 in a cartridge 1, the sucking device 20 generates a depression in an upper volume, not occupied by the liquid product 5. Similar to the sucking device 15, also the sucking device 20 is designed to generate a depression inside each cartridge 1 in an upper volume not occupied by the liquid product 5, by sucking only and exclusively air, i.e. without sucking any part of the liquid product 5 or a possible foam that is generated during the feeding of the liquid product 5; this result is obtained by causing the sucking device 20 to generate a depression sufficient to suck part of the air but completely insufficient to suck any part of the liquid product 5 or any foam that is generated during the feeding of the liquid product 5.

[0028] The sucking device 20 comprises, for each cartridge 1 located in the capping station S3, a chamber 21 inside which the depression is generated and along which the piston 4, pushed by the pushing device 20, is caused to pass.

[0029] According to a possible embodiment illustrated in FIG. 3, the sucking device 20 comprises a plurality of elastic caps 22 (only one of which is illustrated in FIG. 3), each of which is designed to engage the open upper end of a corresponding cartridge 1 in a sealing manner, and forming the terminal part of a chamber 21. Each chamber 21 (and therefore each elastic cap 22) is connected by means of a flexible duct to a suction source 23 (typically a vacuum pump) which can be common for all chambers 21 (and therefore for all the elastic caps 22).

[0030] According to a possible embodiment, the sucking device 20 is designed to generate a depression inside each cartridge 1 ranging from 1,000 to 10,000 Pascals and is designed to maintain the depression for a time ranging from 0.2 to 2 seconds.

[0031] According to a preferred embodiment illustrated in FIG. 3, a resting station S4 is arranged between the degasification station S2 and the capping station S3, in which the end of each cartridge 1 is free and in communication with the external environment.

[0032] According to an alternative not illustrated, the filling unit 11 comprises a further sucking device, located at the filling station S1, designed to generate a depression inside each cartridge 1 during filling, even if this depression is (in absolute value), lower than that performed in the degasification station S2 and in the capping station S3 (i.e. weaker).

[0033] The embodiments described herein can be combined with each other without departing from the scope of the present invention.

[0034] The filling unit 11 described above has numerous advantages.

[0035] Firstly, the filling unit 11 described above allows to obtain closed, liquid filled containers, in which no air bubbles inside the liquid are present.

[0036] Secondly, the filling unit 11 described above allows to speed up the delivery of the liquid product 5 into the filling station 1 (therefore, allowing an increased operating speed) without penalizing the final quality of the cartridges 1 since any excess air trapped in the liquid inside the cartridges 1 is efficiently and effectively evacuated by the action of the two sucking devices 15 and 20.

[0037] In addition, the filling unit 11 described above is simple and inexpensive to implement, since compared to a similar known filling unit requires the addition of a few elements (the two sucking devices 15 and 20) formed by commercial components.