SILVER FLUORIDE SOLUTIONS FOR DENTAL COMPOSITIONS

Abstract

The present invention relates to an aqueous Silver Fluoride (AgF) containing solutions with pH 4.0-5.3.

Claims

1. An aqueous Silver Fluoride (AgF) containing solution with pH 4.0-5.3, wherein the composition is stabilized with an acid.

2. An aqueous Silver Fluoride solution as defined in claim 1, wherein the acid is nitric acid.

3. An aqueous Silver Fluoride solution as defined in claim 1, wherein the quantity of Silver Fluoride in the aqueous Silver Fluoride solution is about and up to 50% w/v.

4. An aqueous Silver Fluoride solution as defined in claim 2, wherein the quantity of Silver Fluoride in the aqueous Silver Fluoride solution is about and up to 50% w/v.

Description

EXAMPLE

[0012] Three aqueous 38% (w/v) silver fluoride products were prepared, with each solution exhibiting a different pH. The products were tested for the performance attributes detailed in Table 1.

TABLE-US-00001 TABLE 1 Comparative Comparative Example 1 Example 1 Example 2 Product 38% AgF w/v 38% AgF w/v 38% AgF w/v (stabilized with (not stabilized) (stabilized with nitrate) ammonia) pH  5.1  6.3 13.0 Appearance Clear colour- Clear colour- Clear colour- (1 year @ 23° C.) less liquid, no less liquid, less liquid, no (silver) sedi- (silver) sedi- (silver) sedi- ment ment present ment AgF content in 37.6% w/v 9.6% w/v 37.7% w/v solution (1 year @ 23° C.) * Hydraulic 87.2 86.2 89.4 conductance (Lp %) (AgF + KI) * Hydraulic conductance (Lp %) is used to determine the reduction of fluid movement through dentinal tubules (0%—No occlusion, 100%—complete occlusion, no fluid movement). Fluid movement through dentinal tubules can be the cause of tooth hypersensitivity, therefore Lp % represents the desensitizing effect. The application of a second step (Potassium Iodide solution) was applied to all example products to test whether the silver iodide precipitate will form to occlude dentin tubules with each of the different silver fluoride solutions.

CONCLUSION

[0013] Ex 1: Good stability upon storage, good tubule occlusion and biologically compatible pH (no soft-tissue irritation)
Comp Ex 1: Poor stability upon storage, good tubule occlusion and biologically compatible pH (no soft-tissue irritation).
Comp Ex 2: Good Stability upon storage, good tubule occlusion, biologically incompatible pH (soft-tissue irritation.

[0014] Modifications and variations as would be apparent to a skilled addressee are deemed to be within the scope of the present invention.