COSMETIC COMPOSITION FOR MOLDING, COMPRISING CALCINED LAYERED DOUBLE HYDROXIDE AND POLYMER

Abstract

The present invention relates to a cosmetic composition for molding, comprising a calcined layered double hydroxide and a polymer and, more specifically, to a cosmetic composition for molding and a preparation method therefor, the cosmetic composition comprising an active ingredient, a calcined layered double hydroxide, a polymer, and a solvent

Claims

1. A cosmetic composition for molding, which comprises an active ingredient, a calcined layered double hydroxide, a polymer and a solvent.

2. The cosmetic composition for molding according to claim 1, which comprises 0.01 to 50% by weight of active ingredient, 10 to 60% by weight of calcined layered double hydroxide, 0.5 to 20% by weight of polymer and 10 to 60% by weight of solvent.

3. The cosmetic composition for molding according to claim 2, which comprises 0.1 to 48% by weight of active ingredient, 15 to 55% by weight of calcined layered double hydroxide, 1 to 18% by weight of polymer and 15 to 55% by weight of solvent.

4. The cosmetic composition for molding according to claim 3, which comprises 1 to 45% by weight of active ingredient, 20 to 50% by weight of calcined layered double hydroxide, 2 to 15% by weight of polymer and 20 to 50% by weight of solvent.

5. The cosmetic composition for molding according to claim 1, wherein the active ingredient is one or more selected from the group consisting of a moisturizer, a whitening agent, an anti-wrinkle agent, a UV blocking agent, a hair growth promoter, vitamin or a derivative thereof, amino acid or peptide, an anti-inflammatory agent, an acne therapeutic agent, a microbicide, female hormone, a keratolytic agent and a natural product.

6. The cosmetic composition for molding according to claim 1, wherein the calcined layered double hydroxide has the following formula:
[M.sup.2+.sub.1-xM.sup.3+.sub.x(OH).sub.2].sup.x+(A.sup.n−).sub.x/n.mH.sub.2O wherein M.sup.2+ and M.sup.3+ are metal cations, A.sup.n− is anion, 0.2≤x≤0.33, n is 1 or 2, and m is 0.5 to 4.

7. The cosmetic composition for molding according to claim 6, wherein M.sup.2+ is Ca.sup.2+, Mg.sup.2+, Zn.sup.2+, Ni.sup.2+, Mn.sup.2+, Co.sup.2+or Fe.sup.2+; M.sup.3+is Al.sup.3+, Cr.sup.3+, Mn.sup.3+, Fe.sup.3+, Ga.sup.3+, Co.sup.3+or Ni.sup.3+; and A.sup.n− is OH.sup.−, F.sup.−, Cl.sup.−, Br.sup.−, I.sup.−, NO.sub.3, CO.sub.3.sup.2− or SO.sub.4.sup.2−.

8. The cosmetic composition for molding according to claim 1, wherein the calcined layered double hydroxide is calcined at a temperature of 400 to 1,200° C.

9. The cosmetic composition for molding according to claim 8, wherein the calcined layered double hydroxide is calcined at a temperature of 500 to 1,100° C.

10. The cosmetic composition for molding according to claim 1, wherein the calcined layered double hydroxide is calcined for 6 to 16 hours.

11. The cosmetic composition for molding according to claim 10, wherein the calcined layered double hydroxide is calcined for 8 to 14 hours.

12. The cosmetic composition for molding according to claim 1, wherein the polymer is one or more selected from the group consisting of cellulose, methylcellulose, hydroxyethyl cellulose, microcrystalline cellulose, nanocellulose, starch, polymethyl methacrylate, polyacrylic acid, acrylates/C10-30 alkyl acrylate crosspolymer, polyvinyl alcohol, polyvinylpyrrolidone, polyglycolide, xanthan gum, acacia gum, guar gum, carrageenan gum, gellan gum, karaya gum, locust bean gum, hyaluronic acid, pullulan, sodium alginate, chitosan, agar, gelatin and collagen.

13. The cosmetic composition for molding according to claim 1, wherein the solvent is selected from water, glycerin, propylene glycol, butylene glycol, diglycerin, dipropylene glycol and a mixture thereof.

14. A method for preparing a cosmetic composition for molding comprising: i) calcining a layered double hydroxide at a temperature of 400 to 1,200° C. for 6 to 16 hours and cooling; and ii) dissolving an active ingredient and a polymer in a solvent, mixing the obtained solution with the calcined layered double hydroxide and stirring.

15. The method for preparing a cosmetic composition for molding according to claim 14, wherein the layered double hydroxide has the following formula:
[M.sup.2+.sub.1-xM.sup.3+.sub.x(OH).sub.2].sup.x+(A.sup.n−).sub.x/n.mH.sub.2O wherein M.sup.2+ and M.sup.3+ are metal cations, A.sup.n− is anion, 0.2≤x≤0.33, n is 1 or 2, and m is 0.5 to 4.

16. The method for preparing a cosmetic composition for molding according to claim 15, wherein M.sup.2+is Ca.sup.2+, Mg.sup.2+, Zn.sup.2+, Ni.sup.2+, Mn.sup.2+, Co.sup.2+or Fe.sup.2+; M.sup.3+is Al.sup.3+, Cr.sup.3+, Mn.sup.3+, Fe.sup.3+, Ga.sup.3+, Co.sup.3+or Ni.sup.3+; and A.sup.n− is OH.sup.−, F.sup.−, Cl.sup.−, Br.sup.−, I.sup.−, NO.sub.3, CO.sub.3.sup.2− or SO.sub.4.sup.2−.

17. The method for preparing a cosmetic composition for molding according to claim 14, wherein the layered double hydroxide is calcined at a temperature of 500 to 1,100° C.

18. The method for preparing a cosmetic composition for molding according to claim 14, wherein the layered double hydroxide is calcined for 8 to 14 hours.

19. The method for preparing a cosmetic composition for molding according to claim 14, wherein the active ingredient is one or more selected from the group consisting of a moisturizer, a whitening agent, an anti-wrinkle agent, a UV blocking agent, a hair growth promoter, vitamin or a derivative thereof, amino acid or peptide, an anti-inflammatory agent, an acne therapeutic agent, a microbicide, female hormone, a keratolytic agent and a natural product.

20. The method for preparing a cosmetic composition for molding according to claim 14, wherein the polymer is one or more selected from the group consisting of cellulose, methylcellulose, hydroxyethyl cellulose, microcrystalline cellulose, nanocellulose, starch, polymethyl methacrylate, polyacrylic acid, acrylates/C10-30 alkyl acrylate crosspolymer, polyvinyl alcohol, polyvinylpyrrolidone, polyglycolide, xanthan gum, acacia gum, guar gum, carrageenan gum, gellan gum, karaya gum, locust bean gum, hyaluronic acid, pullulan, sodium alginate, chitosan, agar, gelatin and collagen.

21. The method for preparing a cosmetic composition for molding according to claim 14, wherein the solvent is selected from water, glycerin, propylene glycol, butylene glycol, diglycerin, dipropylene glycol and a mixture thereof.

22. The method for preparing a cosmetic composition for molding according to claim 14, wherein the weight ratio of the active ingredient, the polymer, the solvent and the calcined layered double hydroxide in step (ii) is 0.01 to 50% by weight, 0.5 to 20% by weight, 10 to 60% by weight and 10 to 60% by weight, respectively.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0035] FIG. 1 is a scheme representing the layered structure and composition of layered double hydroxide (LDH).

[0036] FIG. 2 is photographs taken after molding the cosmetic composition for molding of the present invention in various shapes in Example 11.

[0037] FIG. 3 is a photograph taken after molding the cosmetic composition for molding of the Comparative Example.

[0038] FIG. 4 is a result of measuring zeta potential of the composition prepared in Example 1 by the use of Photal, ELS-Z.

[0039] FIG. 5 is a result of measuring the stability of the composition prepared in Example 1 by the use of Turbiscan.

[0040] FIG. 6 is a cryo-electron microscopy photograph of the composition prepared in Example 1.

DETAILED DESCRIPTION

[0041] Hereinafter, the present invention is explained in more detail with the following examples. However, it must be understood that the protection scope of the present invention is not limited to the examples.

Preparation Example 1: Synthesis of Aluminum/Magnesium Hydroxide Stearate

[0042] A commercially available product was purchased from Taesan Chemical (Korea).

Preparation Example 2: Synthesis of ZnAl-LDH

[0043] ZnAl-LDH containing carbonate ion was synthesized by co-precipitation as follows. 1 M Na.sub.2CO.sub.3 solution was slowly added to the mixed solution of 0.2 M Zn(NO.sub.3).sub.2 and 0.1 M Al(NO.sub.3).sub.3 until the final pH became about 7.0. The mixed solution was kept in an about 70° C. oven for a day, filtered, washed with distilled water and ethanol, and dried by the use of a vacuum pump. The formula of the synthesized c-LDH is as follows: [Zn.sub.4Al.sub.2(OH).sub.12]CO.sub.3.xH.sub.2O.

Preparation Example 3: Synthesis of MgAl-LDH

[0044] MgAl-LDH containing carbonate ion was synthesized by co-precipitation as follows. 1 M Na.sub.2CO.sub.3 solution was slowly added to the mixed solution of 0.2 M Mg(NO.sub.3).sub.2 and 0.1 M Al(NO.sub.3).sub.3 until the final pH became about 7.0. The mixed solution was kept in an about 70° C. oven for a day, filtered, washed with distilled water and ethanol, and dried by the use of a vacuum pump. The formula of the synthesized c-LDH is as follows: [Mg.sub.4Al.sub.2(OH).sub.12]CO.sub.3.xH.sub.2O.

Preparation Example 4: Synthesis of Aluminum/Magnesium Silicate

[0045] A commercially available product was purchased from BYK-Chemie GmbH (Germany).

Example 1: Preparation of Composition for Molding Containing Vitamin

[0046] According to the constitutional composition of Table 1, aluminum/magnesium hydroxide stearate obtained in Preparation Example 1 was heated in a furnace at a temperature of 1,000° C. for 12 hours and then cooled to 20° C. After dissolving retinol as an active ingredient and chitosan as a polymer in water, the calcined aluminum/magnesium hydroxide stearate was mixed thereto and stirred with a mixer for 20 minutes to obtain a composition for molding.

TABLE-US-00001 TABLE 1 Ingredient Content (% by weight) LDH of Preparation Example 1 40 Chitosan 4 Retinol 20 Distilled water 36 Total amount 100

Example 2: Preparation of Composition for Molding Containing Peptide

[0047] A composition for molding was prepared by the same method as described in Example 1 except that the ingredients and constitutional composition of Table 2 were used.

TABLE-US-00002 TABLE 2 Ingredient Content (% by weight) LDH of Preparation Example 2 40 Acrylates/C10-30 alkyl acrylate 4 crosspolymer 20 Copper peptide 36 Distilled water Total amount 100

Example 3: Preparation of Composition for Molding Containing Whitening Agent

[0048] A composition for molding was prepared by the same method as described in Example 1 except that the ingredients and constitutional composition of Table 3 were used.

TABLE-US-00003 TABLE 3 Ingredient Content (% by weight) LDH of Preparation Example 3 40 Polyvinyl alcohol 4 Arbutin 20 Propylene glycol 36 Total amount 100

Example 4: Preparation of Composition for Molding Containing Natural Product

[0049] A composition for molding was prepared by the same method as described in Example 1 except that the ingredients and constitutional composition of Table 4 were used.

TABLE-US-00004 TABLE 4 Ingredient Content (% by weight) LDH of Preparation Example 4 40 Starch 4 Redstem wormwood extract 20 Glycerin 36 Total amount 100

Example 5: Preparation of Composition for Molding in Formulation of Cleansing 1

[0050] A composition for molding was prepared by the same method as described in Example 1 except that the ingredients and constitutional composition of Table 5 were used.

TABLE-US-00005 TABLE 5 Ingredient Content (% by weight) LDH of Preparation Example 2 40 Methylcellulose 5 Sodium stearoyl glutamate 8 Disodium stearoyl glutamate 8 Sodium lauroyl glutamate 7 PEG-400 8 Glycerin 24 Total amount 100

Example 6: Preparation of Composition for Molding in Formulation of Cleansing 2

[0051] A composition for molding was prepared by the same method as described in Example 1 except that the ingredients and constitutional composition of Table 6 were used.

TABLE-US-00006 TABLE 6 Ingredient Content (% by weight) LDH of Preparation Example 1 38 Microcrystalline cellulose 7 Sodium lauryl glucose carboxylate 8 Sodium methyl cocoyl taurate 8 Sodium lauroyl sarcosinate 7 Betain 8 Distilled water 24 Total amount 100

Example 7: Preparation of Composition for Molding in Formulation of Cleansing 3

[0052] A composition for molding was prepared by the same method as described in Example 1 except that the ingredients and constitutional composition of Table 7 were used.

TABLE-US-00007 TABLE 7 Ingredient Content (% by weight) LDH of Preparation Example 3 39 Polyvinylpyrrolidone 5 Sodium laures sulfate 8 Sodium cocoyl glutamate 8 Sodium decyl sulfate 8 PEG-400 8 Dipropylene glycol 24 Total amount 100

Example 8: Preparation of Composition for Molding in Formulation of Cleansing 3

[0053] A composition for molding was prepared by the same method as described in Example 1 except that the ingredients and constitutional composition of Table 8 were used.

TABLE-US-00008 TABLE 8 Ingredient Content (% by weight) LDH of Preparation Example 4 28 Polyvinyl alcohol 12 Sodium bicarbonate 7 Mannitol 14 Trehalose 7 Distilled water 32 Total amount 100

Example 9: Preparation of Composition for Molding in Formulation of Foaming Agent for Bubble Bath

[0054] A composition for molding was prepared by the same method as described in Example 1 except that the ingredients and constitutional composition of Table 9 were used.

TABLE-US-00009 TABLE 9 Ingredient Content (% by weight) LDH of Preparation Example 1 39 Polyvinylpyrrolidone 5 Citric acid 8 Sodium bicarbonate 8 PEG-6000 8 PEG-4000 8 Glycerin 24 Total amount 100

Example 10: Preparation of Composition for Molding in Formulation of Essence

[0055] A composition for molding was prepared by the same method as described in Example 1 except that the ingredients and constitutional composition of Table 10 were used.

TABLE-US-00010 TABLE 10 Ingredient Content (% by weight) LDH of Preparation Example 3 35 Hydroxyethyl cellulose 6 Mannitol 18 Trehalose 5 Collagen 8 Hyaluronic acid 7 Distilled water 21 Total amount 100

Example 11: Molding of Composition for Molding

[0056] The molding compositions obtained in Examples 1 to 10 were put into a mold in various shapes to be molded, and then dried in a drying oven at a temperature of 50 to 60° C. for 6 hours (FIG. 2).

Comparative Example

[0057] A composition for molding containing vitamin was prepared in the same manner as in Example 1 except that the layered double hydroxide which did not undergo a calcination step was used, and then the obtained composition for molding was molded (FIG. 3).

Experimental Example 1: Measurement of Zeta Potential

[0058] The zeta potential of the composition prepared in Example 1 was measured by the use of Photal, ELS-Z, and it can be known that the zeta potential is −52.58 mV (FIG. 4).

Experimental Example 2: Measurement of Stability

[0059] The stability of the composition prepared in Example 1 was measured by the use of Turbiscan. As a result, the stability of the composition was confirmed since there was little change in ΔT, ΔBS (FIG. 5).

Experimental Example 3: Cryo-Electron Microscopy

[0060] Photographs of the composition prepared in Example 1 were taken by the use of a cryo-electron microscope (JEM 1010, JEOL Ltd., Japan) (FIG. 6).

Experimental Example 4: Test for Effect on Promoting Transdermal Absorption

[0061] The artificial skin, Strat-M® Membrane (Transdermal Diffusion Test Model) was mounted to a Franz-type diffusion cell (Transdermal Semi-Auto Diffusion Cell, LOGAN Instruments, USA). 50 mM phosphate buffer (pH 7.4, 0.1M NaCl) was added to a receptor cell (5 ml) of the Franz-type diffusion cell. A diffusion cell was then mixed and diffused at 600 rpm, 32° C., and 50 μl of the composition of Example 1 was added to a donor cell. Absorption and diffusion were carried out according to the predetermined time, and the area of the skin where the absorption and diffusion were carried out was 0.64 cm.sup.2. After finishing the absorption and diffusion of the active ingredient, the residues—which were not absorbed and remained on the skin—were cleaned with dried Kimwipes™ or 10 ml of ethanol. The skin in which the active ingredient was absorbed and diffused was homogenized by the use of a tip-type homogenizer, and retinol absorbed into the skin was then extracted with 4 ml of dichloromethane. The extract was then filtrated with a 0.45 μm nylon membrane filter. The content of retinol was measured by high-performance liquid chromatography with the following conditions. As a result, it was confirmed that retinol can be efficiently delivered into the skin since the transdermal absorption is 0.364 μg. [0062] Column: C18 (4.6×200 mm, 5 μm) [0063] Mobile phase: methanol:hexane=2:1 [0064] Flow rate: 0.8 ml/min [0065] Detector: UV 275 nm