Substance for Treating and/or Preventing Intolerance Diseases, and Design Method and Preparation Method thereof

Abstract

The present invention discloses a substance for treating and/or preventing intolerance diseases and a design method and preparation method thereof. The stable structure corresponding to the substance related to the intolerance disease is used as the substance for treating and/or preventing the intolerance disease. The essence of disease is the imbalance of biological structure system. The imbalance of the structure of the substance in the biological structure system will cause diseases related to said substance. The present disclosure relates to the treatment and/or prevention of the intolerance disease by recognizing the stable structure corresponding to the substance by the body, adjusting the expression of its gene expression or genes by the self-adaptation, self-organization and other functions of body's structural system, and restoring the balance of the structure of the substance in the biological structure system.

Claims

1.-129. (canceled)

130. A method for designing substances for treating and/or preventing intolerance diseases, characterized in that: the stable structure corresponding to the substance related to the intolerance disease is used as the substance for treating and/or preventing said intolerance disease; and the stable structure corresponding to the substance is characterized by the structure of said substance that exists in a solid state at a temperature of 500° C. or higher.

131. The method according to claim 130, characterized in that said stable structure corresponding to the substance related to the intolerance disease is selected from one or more of the following: (1) the stable structure corresponding to the substance that causes intolerance disease in the organism; (2) the stable structure corresponding to the substance of the organism itself and related to intolerance disease; (3) the stable structure corresponding to the substance that inhibits the structure that causes intolerance disease; (4) the stable structure corresponding to the substance containing a substance of any one of (1) to (3) above.

132. The method according to claim 130, wherein said intolerance disease is selected from food intolerance, barley intolerance, wheat intolerance, corn intolerance, millet intolerance, apple intolerance, banana intolerance, grape intolerance, beef intolerance, chicken intolerance, carrot intolerance, cucumber intolerance, eggplant intolerance, celery intolerance, butter intolerance, milk intolerance, egg intolerance, lima beans intolerance, honey intolerance, cashew intolerance, peanut intolerance, soybean intolerance, crab intolerance, shrimp intolerance, coffee intolerance, polysaccharide intolerance, biogenic amine intolerance, food additives intolerance, alcohol intolerance, drug intolerance, anti-infectives intolerance, cardiovascular drugs intolerance, and skin intolerance.

133. The method according to claim 131, wherein said intolerance disease is selected from food intolerance, barley intolerance, wheat intolerance, corn intolerance, millet intolerance, apple intolerance, banana intolerance, grape intolerance, beef intolerance, chicken intolerance, carrot intolerance, cucumber intolerance, eggplant intolerance, celery intolerance, butter intolerance, milk intolerance, egg intolerance, lima beans intolerance, honey intolerance, cashew intolerance, peanut intolerance, soybean intolerance, crab intolerance, shrimp intolerance, coffee intolerance, polysaccharide intolerance, biogenic amine intolerance, food additives intolerance, alcohol intolerance, drug intolerance, anti-infectives intolerance, cardiovascular drugs intolerance, and skin intolerance.

134. A substance for treating and/or preventing intolerance diseases designed by a method characterized in that: the stable structure corresponding to the substance related to the intolerance disease is used as the substance for treating and/or preventing said intolerance disease; and the stable structure corresponding to the substance is characterized by the structure of said substance that exists in a solid state at a temperature of 500° C. or higher.

135. The substance according to claim 134, characterized in that said stable structure corresponding to the substance related to the intolerance disease is selected from one or more of the following: (1) the stable structure corresponding to the substance that causes intolerance disease in the organism; (2) the stable structure corresponding to the substance of the organism itself and related to intolerance disease; (3) the stable structure corresponding to the substance that inhibits the structure that causes intolerance disease; (4) the stable structure corresponding to the substance containing a substance of any one of (1) to (3) above.

136. The substance according to claim 134, wherein said intolerance disease is selected from food intolerance, barley intolerance, wheat intolerance, corn intolerance, millet intolerance, apple intolerance, banana intolerance, grape intolerance, beef intolerance, chicken intolerance, carrot intolerance, cucumber intolerance, eggplant intolerance, celery intolerance, butter intolerance, milk intolerance, egg intolerance, lima beans intolerance, honey intolerance, cashew intolerance, peanut intolerance, soybean intolerance, crab intolerance, shrimp intolerance, coffee intolerance, polysaccharide intolerance, biogenic amine intolerance, food additives intolerance, alcohol intolerance, drug intolerance, anti-infectives intolerance, cardiovascular drugs intolerance, and skin intolerance.

137. The substance according to claim 135, wherein said intolerance disease is selected from food intolerance, barley intolerance, wheat intolerance, corn intolerance, millet intolerance, apple intolerance, banana intolerance, grape intolerance, beef intolerance, chicken intolerance, carrot intolerance, cucumber intolerance, eggplant intolerance, celery intolerance, butter intolerance, milk intolerance, egg intolerance, lima beans intolerance, honey intolerance, cashew intolerance, peanut intolerance, soybean intolerance, crab intolerance, shrimp intolerance, coffee intolerance, polysaccharide intolerance, biogenic amine intolerance, food additives intolerance, alcohol intolerance, drug intolerance, anti-infectives intolerance, cardiovascular drugs intolerance, and skin intolerance.

138. A method of preparing the substance for treating and/or preventing intolerance disease according to claim 134, characterized in that the stable structure corresponding to the substance is prepared by a high-temperature carbonization method.

139. The method according to claim 138, characterized in that said stable structure corresponding to the substance related to the intolerance disease is selected from one or more of the following: (1) the stable structure corresponding to the substance that causes intolerance disease in the organism; (2) the stable structure corresponding to the substance of the organism itself and related to intolerance disease; (3) the stable structure corresponding to the substance that inhibits the structure that causes intolerance disease; (4) the stable structure corresponding to the substance containing a substance of any one of (1) to (3) above.

140. The method according to claim 138, wherein said intolerance disease is selected from food intolerance, barley intolerance, wheat intolerance, corn intolerance, millet intolerance, apple intolerance, banana intolerance, grape intolerance, beef intolerance, chicken intolerance, carrot intolerance, cucumber intolerance, eggplant intolerance, celery intolerance, butter intolerance, milk intolerance, egg intolerance, lima beans intolerance, honey intolerance, cashew intolerance, peanut intolerance, soybean intolerance, crab intolerance, shrimp intolerance, coffee intolerance, polysaccharide intolerance, biogenic amine intolerance, food additives intolerance, alcohol intolerance, drug intolerance, anti-infectives intolerance, cardiovascular drugs intolerance, and skin intolerance.

141. The method according to claim 139, wherein said intolerance disease is selected from food intolerance, barley intolerance, wheat intolerance, corn intolerance, millet intolerance, apple intolerance, banana intolerance, grape intolerance, beef intolerance, chicken intolerance, carrot intolerance, cucumber intolerance, eggplant intolerance, celery intolerance, butter intolerance, milk intolerance, egg intolerance, lima beans intolerance, honey intolerance, cashew intolerance, peanut intolerance, soybean intolerance, crab intolerance, shrimp intolerance, coffee intolerance, polysaccharide intolerance, biogenic amine intolerance, food additives intolerance, alcohol intolerance, drug intolerance, anti-infectives intolerance, cardiovascular drugs intolerance, and skin intolerance.

142. A method of treating and/or preventing an intolerance disease in a subject in need thereof, comprising administering the substance of claim 134 to the subject.

143. The method according to claim 142, wherein said intolerance disease is selected from food intolerance, barley intolerance, wheat intolerance, corn intolerance, millet intolerance, apple intolerance, banana intolerance, grape intolerance, beef intolerance, chicken intolerance, carrot intolerance, cucumber intolerance, eggplant intolerance, celery intolerance, butter intolerance, milk intolerance, egg intolerance, lima beans intolerance, honey intolerance, cashew intolerance, peanut intolerance, soybean intolerance, crab intolerance, shrimp intolerance, coffee intolerance, polysaccharide intolerance, biogenic amine intolerance, food additives intolerance, alcohol intolerance, drug intolerance, anti-infectives intolerance, cardiovascular drugs intolerance, and skin intolerance, in the preparation of medicines, health products, foods, and food additives.

Description

DETAILED DESCRIPTION

[1260] The present invention discloses substances for treating and/or preventing intolerance diseases, the design method and the preparation method thereof. Those skilled in the art can learn from the content of this article, use different materials, improve the process or adopt other similar processes for preparation, all of which are considered to be included in the present invention. In particular, it should be pointed out that all such substitutions and modifications will be apparent to those skilled in the art and are intended to be included herein. While the methods and products of the present invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications of the methods described herein, as well as appropriate variations and combinations, may be made to implement and use the techniques of the present invention without departing from the spirit and scope of the invention.

[1261] In order to further understand the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the examples of the present invention, and it is obvious that the described examples are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.

[1262] The specific embodiments are as follows:

Example 1: Substance for Treating and/or Preventing Egg Intolerance and Preparation Method Thereof

[1263] Since eggs contain substances causing egg intolerance and are easily available, it is preferable to use the stable structure corresponding to egg as the substance for treating and/or preventing egg intolerance. If other organs or tissues also contain the substance related to egg intolerance disease, it is also preferable to use the stable structure corresponding to the organ or tissue containing the substance related to egg intolerane disease as the substance for treating and/or preventing egg intolerane, so that the complicated problems can be simplified, and the substance for treating and/or preventing egg intolerane can be designed and prepared without knowing the specific structure of the intolerant substance and pathogenic mechanism.

[1264] The egg is carbonized at high temperature to obtain the substance for treating and/or preventing egg intolerane.

Example 2: Substance for Treating and/or Preventing Wheat Intolerance and Preparation Method Thereof

[1265] Since wheats contain substances causing wheat intolerance and are easily available, it is preferable to use the stable structure corresponding to wheat as the substance for treating and/or preventing wheat intolerance. If other organs or tissues also contain the substance related to wheat intolerance disease, it is also preferable to use the stable structure corresponding to the organ or tissue containing the substance related to wheat intolerane disease as the substance for treating and/or preventing wheat intolerane, so that the complicated problems can be simplified, and the substance for treating and/or preventing wheat intolerane can be designed and prepared without knowing the specific structure of the intolerant substance and pathogenic mechanism.

[1266] The wheat is carbonized at high temperature to obtain the substance for treating and/or preventing wheat intolerane.

[1267] Using the same method, the present invention prepared a series of substances for treating and/or preventing intolerane diseases caused by different intolerant substances.

Example 3: Clinical Application Test of the Substances Prepared in Example 1 and Example 2 and Various Substances for Treating Intolerance Diseases Prepared in the Same Manner in the Treatment of Intolerance Diseases

[1268] 1. Clinical data: A total of 60 outpatients were recruited, of which 28 were males and 32 were females, aged 4 to 68 years old, including 28 cases of gastrointestinal discomfort (symptoms include various degrees of abdominal pain, constipation or diarrhea, abdominal fullness, bad breath, etc.), 25 cases of skin reactions (various dermatitis, urticaria, erythema, etc.), 13 cases of migraine and sleep disorders, and other diseases such as asthma, rhinitis, joint pain, etc.
2. Diagnostic criteria: A double-blind placebo-controlled drug challenge test was performed based on the patient's medical history as the diagnostic criteria for testing drug intolerance.
3. Treatment method: Patients were orally administered the substance for treating intolerance diseases prepared in Example 1 and Example 2, once a day, 3 g/time, for 3 days continuously.
4. Criteria for judging the treatment effect: According to the changes in the clinical symptoms of patients after treatment.
5. Efficacy results: After treatment, up to 55 patients were cured and 4 patients were markedly improved, with a total effective rate of 98.33%. After treatment, these patients did not show any symptoms after repeated administration of drugs that caused intolerance. At the same time, there were no side effects and drug dependence during the observation period.