TRANSPORT LOCK ASSEMBLY, AND A MEDICAMENT DELIVERY DEVICE COMPRISING THE TRANSPORT LOCK ASSEMBLY

Abstract

A transport lock assembly for a medicament delivery device, wherein the transport lock assembly comprises a powerpack (30) having a locking member (50, 50′, 50″) configured to interact with a control member (60), which locking member (50, 50′, 50″) is movable, relative to the control member (60), from a first state in which the control member (60) is immobilized, to a second state in which the control member (60) is free to move; wherein the transport lock assembly further comprises a housing part (20) having a key member (22), such that assembly of the powerpack (30) with the housing part (20) causes the key member (22) to move the locking member (50, 50′, 50″) from the first state to the second state.

Claims

1-12. (canceled)

13: A medicament delivery device comprising: a housing having an open terminal distal end and an inner surface comprising a first fastener and a key member; a body comprising a tubular portion, an end cap portion, and a second fastener configured to engage the first fastener, where the body has a first axial position and a second axial position, both relative to the terminal distal end of the housing; a control member rotatably positioned on the tubular portion of the body and having a first mating member; a locking member positioned on the body and having a second mating member configured to engage with the first mating member, wherein when the body is in the first axial position, the first and second mating members are engaged such that rotation of the control member relative to the tubular portion and housing is prevented, and wherein when the body is in the second axial position the first and second fasteners are not engaged.

14: The medicament delivery device of claim 13, wherein movement of the body from the first position to the second position causes the second mating member to engage the key member.

15: The medicament delivery device of claim 13, wherein engagement of the key member with the second mating member causes the second mating member to disengage from the first mating member

16: The medicament delivery device of claim 15, wherein the disengagement of the first mating member from the second mating member allows rotational movement of the control member

17: The medicament delivery device of claim 13, wherein movement of the body from the first position to the second position causes the first and second fasteners to engage and lock the cap portion to the housing such that the body is axially and rotationally fixed relative to the housing.

18: The medicament delivery device of claim 13, wherein the second mating member is positioned on a support member that is an integrated unitary part of the body.

19: The medicament delivery device of claim 18, wherein the support member is axially resiliently compressible.

20: The medicament delivery device of claim 18, wherein the support member is compressed axially in a distal direction as the body moves from the first position to the second position.

21: The medicament delivery device of claim 18, wherein the second mating member disengages from the first mating member as the support member is compressed axially.

22: The medicament delivery device of claim 13, wherein the locking member is resilient and prevents disengagement of the first and second mating members until the body is in the second position and the first and second fasteners are engaged.

23: A medicament delivery device comprising: a housing having an open terminal distal end and an inner surface comprising a first fastener and a key member; and a powerpack comprising a body comprising a tubular portion, an end cap portion, a flexible holding member, and a second fastener configured to engage the first fastener such that the end cap forms a closure of the terminal distal end of the housing; a control member rotatably position on the tubular portion of the body and having a first mating member; a drive member biased by a spring and engaged with the flexible holding member to prevent proximal axial movement of the drive member; and a locking member movable from a first state to a second state and having a second mating member configured to engage with the first mating member, wherein when the locking member is in the first state, the first and second mating members are engaged such that rotation of the control member relative to the tubular portion and housing is prevented, and wherein when the locking member is in the second state the control member can be rotated such that the flexible holding member disengages from the drive member.

24: The medicament delivery device of claim 23, wherein the body is coaxially arranged with the control member and the drive member.

25: The medicament delivery device of claim 23, wherein the body is located radially outside the drive member and radially inside the control member.

26: The medicament delivery device of claim 23, wherein assembly of the powerpack with the housing part causes the key member to move the locking member from the first state to the second state.

27: The medicament delivery device according to claim 23, wherein the control member is rotationally movable around a longitudinal axis, but axially fixed relative to the body, and wherein the locking member is axially movable and rotationally fixed relative to the body and relative to the control member.

28: The medicament delivery device according to claim 23, wherein the drive member is hollow and the spring is partially positioned inside of the drive member.

29: The medicament delivery device of claim 23, wherein the second mating member is positioned on a support member that is an integrated unitary part of the body.

30: The medicament delivery device of claim 29, wherein the support member is axially resiliently compressible.

31: The medicament delivery device of claim 29, wherein the support member is compressed axially in a distal direction as the locking member moves from the first state to the second state.

32: The medicament delivery device of claim 29, wherein the second mating member disengages from the first mating member as the support member is compressed axially.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0036] FIG. 1 a perspective view of a semi-assembled medicament delivery device according to the present disclosure

[0037] FIG. 2 a cross-sectional view of the semi-assembled medicament delivery device of FIG. 1

[0038] FIG. 3 a perspective view of a housing part and of a powerpack of the present disclosure

[0039] FIG. 4 an exploded view of the powerpack of FIG. 3

[0040] FIG. 5a-b cross-sectional views of an assembled medicament delivery device according to the present disclosure

[0041] FIG. 6a-b perspective views of a powerpack according to a further embodiment of the present disclosure

[0042] FIG. 7a-b perspective views of a powerpack according to another embodiment of the present disclosure

DETAILED DESCRIPTION

[0043] FIGS. 1 and 2 show a medicament delivery device 10 in a semi-assembled state in which a front assembly 80 has been mounted in a proximal part of a housing part 20 and in which a powerpack 30 has been partly inserted via a distal end of the housing part 20.

[0044] The front assembly 80 comprises a pre-filled medicament container, having a movable stopper sealing a distal end of the container. A container holder may be provided to retain the medicament container within the housing part 20. A proximal end of the container may comprise a fixedly attached medicament delivery member, such as an injection needle or a mouthpiece. The medicament delivery member may alternatively be designed to be attached to the container, via the container holder at a later stage, before use of the medicament delivery device. In case the medicament delivery member is a fixedly attached injection needle, a needle sheath is provided to protect the injection needle in a sterile environment until the medicament delivery device 10 is ready for use.

[0045] A spring-biased tubular medicament delivery member guard is movably arranged at a proximal end of the housing part 10. The medicament delivery member guard serves to protect and conceal the medicament delivery member, and to activate the powerpack 30 of an assembled medicament delivery device.

[0046] The proximal end of the housing part 20 may further be provided with a removable cap (not shown). In case the container has a fixedly attached injection needle with a needle sheath, the cap may also be provided with a needle sheath remover (not shown), such that the needle sheath is removed from the needle when the cap is removed from the proximal end of the housing part 20.

[0047] FIG. 3 shows a main aspect of the present disclosure, namely the housing part 20 and the powerpack 30 in an unassembled state. The constituent mechanical parts of the medicament delivery device 10 are transported and delivered as sub-assemblies to a site where final assembly is carried out. Final assembly means the process of assembling the sub-assemblies together with the pre-filled medicament container.

[0048] As shown in FIG. 4, the powerpack 30 comprises a spring-biased drive member 70 (spring shown in FIG. 2), e.g. a plunger rod, a body 40 for holding the spring-biased drive member 70 in a pre-tensioned state, a movable control member 60 for releasing the spring-biased drive member 70, and a locking member 50, configured to interact with the control member, which locking member 50 is movable, relative to the control member 60, from a first state in which the control member 60 is immobilized, to a second state in which the control member 60 is free to move.

[0049] The spring-biased drive member 70, further comprises a spring 77 (FIG. 2), which is pre-tensioned between a proximal inner surface 71 of the drive member 70, and distal inner stop wall 41 of the body 40.

[0050] The body 40 may be generally tubular, and may comprise a radially flexible holding member 46, such as an arm having an inward protrusion, which engages a corresponding holding member 76, e.g. a recess, of the spring-biased drive member 70, in order to hold the spring-biased drive member 70 in the pre-tensioned state. The drive member 70 is coaxial with the body 40 and is located radially inside the body 40. The control member 60 may be tubular and is coaxial with the body 40, and is further located radially outside the body 40. An inner surface of the control member 60 abuts the holding member 46 such that it is prevented from flexing radially outwards under the bias of the spring 77 when the control member 60 is in an initial state.

[0051] If the control member 60 is moved to a released state, such as by interaction with the medicament delivery member guard, or by accident, recesses on the inside surface of the control member 60 align with the holding member 46 such that the holding member 46 may flex radially outwards into the recesses, due to the spring 77 forcing the spring-biased drive member forward. Thereby the holding member 46 is forced outwards out of the corresponding holding member 76. When the holding member 46 is disengaged from the corresponding holding member 76, the spring-biased drive member 70 will move proximally. If the medicament delivery device is completely assembled, the spring-biased drive member 70 will abut the stopper of the medicament container, and will consequently drive the stopper forward, proximally, and expel a medicament through the medicament delivery member.

[0052] If the control member 60 is somehow, e.g. by accident, moved to the released state before the medicament delivery device 10 is completely assembled, the spring-biased drive member 70 will be catapulted out of the powerpack 30, which may be harmful to a person handling the device. In addition, the powerpack 30 will be wasted.

[0053] In order to mitigate the problem of accidental activation of the powerpack 30, the control member 60 must be prevented from moving to the released state prematurely.

[0054] In the exemplified embodiment, a locking member 50 is provided to prevent the control member 60 from moving relative to the body 40. More in particular, the control member 60 is rotationally movable around a longitudinal axis, and axially fixed, relative to the body 40, and the locking member 50 is axially movable, and rotationally locked relative to the body 40 and relative to the control member 60. However, the locking member 50 is configured to interact with the control member 60, such that when the locking member 50 is in the first state, the control member 60 is immobilized by the locking member 50. When the locking member 50 is moved to the second state the control member 60 is released by the locking member 50.

[0055] The locking member 50 may move either by axial displacement, e.g. along the body 40, or by axial compression, such that at least a part of the locking member is compressed, causing the locking member 50 to disengage from the control member 60. The locking member 50 may alternatively move by a combination of displacement and compression. The locking member 50 may be located axially next to the control member 60.

[0056] The locking member 50 may comprise support member 56, which may be an annular or tubular member arranged around the body 40. The locking member 50 may further comprise and a mating member 52, arranged on the support member 56. The mating member 52 may be configured as a longitudinally elongated protrusion, which in the first state mates with a corresponding mating member 62 of the control member 60, such as a longitudinally elongated recess of the control member 60, such that rotation of the control member 60 relative to the body 40 and relative to the locking member 50 is prevented. In the second state, the mating member 52 of the locking member 50, is axially separated from the corresponding mating member 62 of the control member 60 such that rotation of the control member 60 relative to the body and relative to the locking member is allowed.

[0057] As shown in FIG. 4, the locking member 50 may comprise a fixing element 53 which may interact with a corresponding fixing element 43 of the body 40 such that the locking member 50 is axially movable but rotationally fixed relative to the body 40. The fixing element 53 may be an inwardly directed protrusion such as a rib, and the corresponding fixing element 43 may be a longitudinally directed depression such as a groove or a slot in a side wall of the body 40. As is common in the art, interacting protrusions and depressions may be interchanged between the components, such that the protrusion is instead arranged on the body 40 and the depression is arranged on an inner wall of the locking member 50.

[0058] As described above, the movement of the locking member 50 may be an axial displacement in relation to the body 40 and to the control member 60, or an axial compression of the locking member 50, or a combination of compression and displacement. As such, the displacement is a movement of the support member 56 and the mating member 52 arranged thereon. The compression movement is an axial compression of the support member 56 such that the mating member 52 arranged thereon is axially displaced in relation to the body 40 and to the control member 60.

[0059] The housing part 20 is configured to receive the powerpack 30. The housing part 20 comprises a key member 22 configured to interact with the locking member 50, such that on assembly of the housing part 20 with the power pack 30, the key member 22 axially moves the locking member 50 from the first state to the second state. Thereafter, the control member 60 is free to move to release the spring-biased drive member 70 upon activation of the medicament delivery device 10.

[0060] The key member 22 may be configured as a distally directed ledge 22, provided at a proximal end of a longitudinal guide 26. The mating member 52 of the locking member 50 may be configured as a guide follower such that the mating member 52 slides along the guide 26 when inserting the powerpack 30 in the housing part 20. Alternatively, the key member 22 may be configured as a structural feature, e.g. a ledge, or a protrusion, of any of the components comprised in the front assembly 80 in the housing part 20.

[0061] In a first embodiment, shown in FIGS. 1-5b, the support member 56 of the locking member 50 is configured as a generally rigid annular or tubular member, arranged around the body 40. A stop element 48, such as a bump or a slight protrusion, is provided on an outer surface of the body 40. The stop element 48 abuts the locking member 50 in the first state, such that a certain threshold force is required to move the locking member 50 from the first state to the second state, in order to prevent unintentional movement of the locking member 50.

[0062] Upon insertion of the powerpack 30 in the housing part 20, the mating member 52 of the locking member 50 slides along the guide 26 of the housing part 20. At a certain pre-determined position, the mating member 52 makes contact with the key member 22. On application of said certain threshold force the powerpack 30 may be further inserted into the housing part 20, causing the key member 22 to axially move the locking member 50 from the first state (FIGS. 2 and 3) to the second state (FIGS. 5a and 5b), during which movement the locking member 50 rides over the stop element 48. The locking member 50 is thereby displaced axially away from the control member 60, such that the control member 60 is free to move.

[0063] Towards the end of the insertion, fastening elements 44 of the body 40 engage with corresponding fastening elements 24 of the housing part 20, e.g. by snap-fit engagement, such that the body 40, and consequently the powerpack 30, and the housing part 20 are locked to each other.

[0064] In a second embodiment, shown in FIGS. 6a and 6b, a support member 56′ of the locking member 50′ is configured as an axially resiliently compressible annular, tubular, or sleeve-like member, arranged around the body 40. A distal end of the support member 56′ rests against a blocking member 47 such that the support member 56′ is prevented from distal displacement. A mating member 52′ of the compressible support member 56′ is engaged with the corresponding mating member 62 of the control member 60 (FIG. 6a). A certain threshold force is required to compress the support member 56′ axially in order to disengage the mating member 52′ from the corresponding mating member 62 (FIG. 6b).

[0065] Upon insertion of the powerpack 30 in the housing part 20, the mating member 52′ of the locking member 50′ slides along the guide 26 of the housing part 20. At a certain pre-determined position, the mating member 52′ makes contact with the key member 22. On application of said certain threshold force the powerpack 30 may be further inserted into the housing part 20, causing the key member 22 to axially move, e.g. compress, the locking member 50′ from the first state (FIG. 6a) to the second state (FIG. 6b), during which movement the mating member 52′ is disengaged from the corresponding mating member 62.

[0066] The resilience of the support member 56′ constantly biases the mating member 52′ into engagement with the corresponding mating member 62. Therefore, if the mating member 50′ should be accidentally moved, i.e. compressed, during handling or transport of the powerpack 30, such as by an impact, the mating member 52′ will instantly re-engage with the corresponding mating member 62 due to the resilience of the support member 56′.

[0067] In a third embodiment, shown in FIGS. 7a and 7b, a support member 56″ of the locking member 50″ is configured as an axially resiliently compressible member which is an integrated unitary part of the body 40. A distal end of the support member 56″ is integrated with the body 40 such that the support member 56″ is prevented from distal displacement. A mating member 52″ of the compressible support member 56″ is engaged with the corresponding mating member 62 of the control member 60 (FIG. 7a). A certain threshold force is required to compress the support member 56″ axially in order to disengage the mating member 52″ from the corresponding mating member 62 (FIG. 7b).

[0068] Upon insertion of the powerpack 30 in the housing part 20, the mating member 52″ of the locking member 50″ slides along the guide 26 of the housing part 20. At a certain pre-determined position, the mating member 52″ makes contact with the key member 22. On application of said certain threshold force the powerpack 30 may be further inserted into the housing part 20, causing the key member 22 to axially move, e.g. compress, the locking member 50″ from the first state (FIG. 7a) to the second state (FIG. 7b), during which movement the mating member 52″ is disengaged from the corresponding mating member 62. The locking member 50″ is thereby moved axially away from the control member 60, such that the control member 60 is free to move.

[0069] An integrated locking member 50″ means fewer components to assemble and reduces the tolerance chain, which leads to a more robust and reliable device. Furthermore, as discussed above in conjunction with the second embodiment, the resilience of the locking member 50″ will cause the mating member 52″ to re-engage with the corresponding mating member 62 if the locking member 50″ should be accidentally moved during handling or transport of the powerpack 30.