ACTIVE AGENTS FOR SKIN AND HAIR CARE WITH SENSORY MODIFYING PROPERTIES

Abstract

The present invention primarily relates to the use of a fatty acid ester or of a mixture of two or more fatty acid esters or of a mixture comprising one or more fatty acid esters, wherein the fatty acid ester or one, two, three or more, preferably all, of the fatty acid ester(s) is/are selected from the group consisting of 3-hydroxypropyl caprylate, glyceryl monocaprylate, 3-hydroxypropyl undecylenate and glyceryl monoundecylenate, for modifying the sensory properties of a skin care product. The present invention further relates to methods for modifying the sensory properties of a skin care product as well as to methods for manufacturing a skin care product and to particular skin care products.

Claims

1. A skin or hair care product comprising one or more fatty acid esters that modify sensory properties of the product, wherein the one or more fatty acid esters are chosen from 3-hydroxypropyl caprylate, glyceryl monocaprylate, 3-hydroxypropyl undecylenate and glyceryl monoundecylenate.

2. The product according to claim 1, wherein the product is a leave-on product or a rinse-off product.

3. The product according to claim 1, wherein the one or more fatty acid esters improves a sensation on the skin and/or improves foam formation on the skin when the product is applied to the skin.

4. The product according to claim 1, wherein the one or more fatty acid esters prevents and/or reduces dandruff.

5. A method for modifying sensory properties of a skin or hair care product comprising: (i) providing ingredients of a skin or hair care product, (ii) providing one or more fatty acid esters chosen from 3-hydroxypropyl caprylate, glyceryl monocaprylate, 3-hydroxypropyl undecylenate, and glyceryl monoundecylenate, (iii) mixing the components of (i) and (ii).

6. The method according to claim 5, wherein the product is a leave-on product or a rinse-off product.

7. The method according to claim 5, wherein the one or more fatty acid esters improves foam formation of the product.

8. The method according to claim 5, wherein the product is a shampoo and the component(s) in (ii) is/are provided in an amount such that the resulting product is an anti-dandruff shampoo.

9. A method for manufacturing a skin or hair care product comprising: (i) providing ingredients of a skin or hair care product, (ii) providing one or more fatty acid esters chosen from 3-hydroxypropyl caprylate, glyceryl monocaprylate, 3-hydroxypropyl undecylenate, and glyceryl monoundecylenate, (iii) mixing the components of (i) and (ii).

10. The method according to claim 9, wherein the product is a shampoo and the component(s) in (ii) is/are provided in an amount such that the resulting product is an anti-dandruff shampoo.

11. The product according to claim 1, wherein the product is a shampoo comprising: (i) water, (ii) one or more surfactant(s) chosen from sodium lauryl ether sulfate, cocamidopropyl betaine, lauryl glucoside, caprylyl/capryl glucoside, sodium lauryl sulfate, disodium laureth sulfosuccinate, sodium lauryl sulfoacetate, decyl glucoside, sodium lauroyl sarcosinate, glycol distearate, coco-betaine, PPG-5-ceteth-20, coco-glucoside, diethylhexyl sodium sulfosuccinate, ammonium cocoyl isethionate, ammonium cocoyl sarcosinate, diethylhexyl sodium sulfosuccinate, cocamide-MEA, PEG-7 glyceryl cocoate, glycol/distearate, and sodium oleoyl sarcosinate, (iii) one or more fatty acid esters chosen from 3-hydroxypropyl caprylate, glyceryl monocaprylate, 3-hydroxypropyl undecylenate, and glyceryl monoundecylenate, (iv) one or more fragrance(s), (v) optionally, one or more plant oil(s) chosen from persea gratissima oil, Olea europaea oil, prunus amygdalus dulcis oil, Helianthus annuus seed oil, Simmondsia chinensis seed oil, mauritia flexuosa fruit oil, calophyllum inophyllum seed oil, and Triticum vulgare germ oil, (vi) optionally, one or more preservative(s) chosen from 2-phenoxyethanol, benzyl alcohol, dehydroacetic acid, methyl paraben, sorbic acid, and benzoic acid, and (vii) optionally, one or more active ingredient(s) chosen from 4-hydroxyacetophenone, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, caprylhydroxamic acid, sorbitan caprylate, ethylhexylglycerine, laureth-9, crisaborol, trideceth-9, PEG-5 isononanoate, 4-t-butylcyclohexanol, hydroxyphenyl propamidobenzoic acid, avananthramides, polyphenols from oats, hydrocortisone, and urea.

12. The product according to claim 1, wherein the product is a hair or body cream comprising: (i) water, (ii) one or more emulsifying agent(s) selected from the group consisting of chosen from PEG-100 stearate, cetearyl glycoside, distearyldimonium chloride, palmitamidopropyltrimonium chloride, glyceryl stearate citrate, glyceryl oleate citrate, polyglyceryl-3 methylglucose distearate, cetearyl alcohol, potassium cetyl phosphate, sodium cetyl phosphate, acrylates/C10-30 alkyl acrylate cross-polymer, ammonium acryloyldimethyltaurate/Beheneth-25 methacrylate crosspolymer, polyglyceryl-4 caprate, polyglyceryl-4 caprylate/caprate, cetyl PEG/PPG-10/1, dimethicone, polyglycer-yl-6 dioleate, polyglyceryl-2 stearate, PEG-30 dipoly-hydroxystearate, sodium stearoyl lactylate, xanthan gum, dehydro xanthan gum, hydrogenated palm glycerides, polyglyerol-3 oleate, polyglyceryl-3 polyricinoleate, sodium caproyl/lauroyl lactylate, glyceryl stearate se, polyglyceryl-3 dicitrate/stearate, and PEG-40 hydrogenated castor oil, (iii) one or more oil body/bodies chosen from caprylic capric triglycerides, mineral oil, Simmondsia chinensis seed oil, butyrospermum parkii butter, dicaprylyl ether, cyclomethicone, dimethicone, C12-15 alkyl benzoate, isopropyl palmitate, isopropyl myristate, octyldodecanol, cetearyl ethylhexanoate, cetearyl nonanoate, ethylhexyl isononanoate, propylene glycol dicaprylate/dicaprate, propylheptyl caprylate, decyl oleate, hexyl laurate, ethylhexyl stearate, triisononanoin, iso-adipate, stearyl heptanoate, and stearyl caprylate, (iv) one or more fatty acid esters chosen from 3-hydroxypropyl caprylate, glyceryl monocaprylate, 3-hydroxypropyl undecylenate, and glyceryl monoundecylenate, (v) one or more fragrance(s), (vi) optionally, one or more preservative(s) chosen from 2-phenoxyethanol, benzyl alcohol, dehydroacetic acid, methyl paraben, sorbic acid and benzoic acid, and (vii) optionally, one or more active ingredient(s) chosen from 4-hydroxyacetophenone, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, caprylhydroxamic acid, sorbitan caprylate, ethylhexylglycerine, laureth-9, crisaborol, trideceth-9, PEG-5 isononanoate, 4-t-butylcyclohexanol, hydroxyphenyl propamidobenzoic acid, avananthramides, polyphenols from oats, hydrocortisone, and urea.

13. The product according to claim 1, wherein the product is in the form of an oil-in-water emulsion, a water-in-oil emulsion, an aqueous formulation, or an aqueous and/or ethanolic and/or glycolic-based formulation.

14. The product according to claim 1, wherein the product is a rinse-off product.

15. The product according to claim 1, wherein the product is a leave-on product.

16. The product according to claim 14, wherein the product is a surfactant-based cleansing product.

17. The product according to claim 16, wherein the product is a shampoo.

18. The product according to claim 17, wherein the shampoo is an anti-dandruff shampoo.

Description

EXAMPLES

1.) Sensory Assessment on Skin of 3-Hydroxypropyl Undecylenate

[0144] To evaluate the influence of 3-hydroxypropyl undecylenate on skin sensation and foam formation, the active ingredient was incorporated at 1 wt.-% dosage into a hair and body shampoo according to table 1.

[0145] Formulation A: Without active (placebo)

[0146] Formulation B: With 1 wt.-% 3-hydroxypropyl undecylenate

TABLE-US-00001 TABLE 1 Hair and body shampoo formulation Placebo INCI A B A. Sodium Laureth Sulfate, 17.0 17.0 Lauryl Glycoside Citric Acid 0.15 0.15 1,2-Hexanediol, Caprylyl Glycol 1.0 1.0 Disodium EDTA 0.1 0.1 Sodium Chloride 0.4 0.4 B. Water (Aqua) 76.2 75.2 C. Potassium Sorbate 0.15 0.15 D. Cocoamidopropyl Betaine 5.0 5.0 3-Hydroxypropyl Undecylenate — 1.0 SUM 100.0

[0147] Eleven subjects were asked to test the active containing formulation B versus placebo A without active according to the procedure described below (samples were coded as A and B as in Table 1).

Test Procedure to Evaluate the Skin Sensation of Hair and Body Shampoo (Leave-on)

[0148] Cleaning of the hands by using 1 ml of a standard shampoo and rinsing water [0149] Drying of the hands by using a towel [0150] Hair and body shampoo (100 μl) was applied by the test manager using an Eppendorf pipette (Placebo without active (A) on the right index finger, formulation with 1 wt.-% active (B) on the left index finger) [0151] Rubbing of the formulations between thumb, index finger and middle finger of the right (A) or left (B) hand for 20 seconds

[0152] Question to be answered by the subjects: [0153] Which formulation (A or B) contains a skin moisturizing, re-fattening additive?

Evaluation of Foam Quality and Skin Sensation (Rinse-Off)

[0154] Cleaning of the hands by using 1 ml of a standard shampoo and rinsing water [0155] Drying of the hands by using a towel [0156] Hair and body shampoo with and without active (100 μl) was applied on the back of the hand by the test manager using an Eppendorf pipette (placebo without active (A) on the back of the left or right hand and formulation with 1 wt.-% active (B) on the back of the opposite hand, respectively) [0157] Rub 3 times and distribute the test sample on the back of each hand [0158] 20 ml of water was rinsed about each back of the hands [0159] Rub for 15 seconds and evaluate the foam volume of each formulation

[0160] Question to be answered by the subjects: [0161] Which formula (A or B) forms a larger quantity of foam during the application? [0162] Wash off the formulation with rinsing water for 1 minute [0163] Pat the skin dry by using a towel [0164] Evaluate the skin sensation after 5 minutes

[0165] Question to be answered by the subjects: [0166] Which formula (A or B) leads to a softer skin sensation?

TABLE-US-00002 TABLE 2 Results of evaluation (voting of eleven subjects) Number of applicants Questions Formulation A Formulation B Which formula contains 3 8 a skin moisturizing/ re-fattening additive? Which formula forms a 3 8 larger quantity of foam during the application? Which formula leads 4 7 to a softer skin sensation?

[0167] It could be clearly demonstrated that the hair and body shampoo formulation containing 1 wt.-% of 3-hydroxypropyl undecylenate (formulation B) leads to a more moisturized, more re-fattened skin sensation versus a placebo formulation without active (formulation A). Eight of eleven applicants voted that formulation B leads to a higher foam volume. Furthermore, seven out of eleven applicants voted that 3-hydroxypropyl undecylenate containing formulation B leads to a softer skin sensation after the formulation was rinsed off (cf. FIG. 1 below, where formulation A is depicted in grey and formulation B is depicted in chequered).

2.) Sensory Assessment on Skin of 3-Hydroxypropyl Caprylate

[0168] To evaluate the influence on skin sensation of 3-hydroxypropyl caprylate, the active ingredient was incorporated at a 1 wt.-% dosage into a hair and body shampoo according to table 3.

[0169] 24 untrained panelists were asked to test the active containing formulation B versus placebo A without active according to the procedure described below (samples were coded A and B as in Table 3).

[0170] Formulation A: Without active (placebo)

[0171] Formulation B: With 1 wt.-% 3-hydroxypropyl caprylate

TABLE-US-00003 TABLE 3 Hair and body shampoo formulation w/w % Placebo INCI A B A. Sodium Laureth Sulfate, 17.0 17.0 Lauryl Glycoside Citric Acid 0.15 0.15 1,2-Hexanediol, Caprylyl Glycol 1.0 1.0 Disodium EDTA 0.1 0.1 Sodium Chloride 0.4 0.4 B. Water (Aqua) 76.2 75.2 C. Potassium Sorbate 0.15 0.15 D. Cocoamidopropyl Betaine 5.0 5.0 3-Hydroxypropyl Caprylate — 1.0 SUM 100.0
Skin Sensation Evaluation of Hair and Body Shampoo with 1 wt.-% 3-Hydroxypropyl Caprylate [0172] Cleaning of the hands by using 1 ml of a standard shampoo and rinsing water [0173] Drying of the hands by using a towel [0174] Hair and body shampoo (100 μl) was applied by the test manager using an Eppendorf pipette (placebo without active (A) on the left or right index finger, formulation with 1 wt.-% active (B) on the opposite index finger, respectively) [0175] Rubbing of the formulations between thumb, index finger and middle finger for 20 seconds [0176] The skin was wetted with rinsing water for 3 seconds [0177] Evaluation of the skin sensation in terms of moisturization/re-fattening properties

[0178] Question to be answered by the panelists: [0179] Which formula (A or B) leads to a more moisturized/re-fattened skin sensation?

[0180] 18 subjects out of 24 voted that formulation B containing 1 wt-% 3-hydroxypropyl caprylate is more moisturizing and re-fattening to the skin (cf. Table 4 and FIG. 2).

TABLE-US-00004 TABLE 4 Results of evaluation (voting of 24 subjects for sample A or B) Number Formulation Formulation of subjects A B 24 6 18 % 25 75

[0181] FIG. 2 depicts the results of the evaluation in % as shown in Table 4 (voting of 24 subjects for A or B).

Foam Behaviour of Hair and Body Shampoo with 1 wt.-% 3-Hydroxypropyl Caprylate Versus Placebo [0182] Hands were prewashed with a standard surfactant solution [0183] 100 μl sample A or B according to Table 3 (random order) is applied on wet hand (on the left hand for right-hander and vice versa) [0184] Sample is foamed for 20 seconds with index and middle finger [0185] Foam volume is evaluated on scale from 1-5 (1=no foam, 5=most foam; cf. Table 5) [0186] Hands were pre-washed again and the other sample is also evaluated [0187] Question: Which formula shows higher foam volume? (Cf. Table 6 and FIG. 4)

TABLE-US-00005 TABLE 5 Results of foam volume evaluation (ranking 0-5; 0 = no foam; 5 = high foam volume) Subject No. Formulation A Formulation B 1 3 3 2 3 4 3 1 2 4 4 4 5 3 3 6 4 3 7 3 5 8 3 5 9 5 5 10 1 5 11 1 2 13 1 2 14 5 5 15 2 3 16 3 4 17 4 5 18 4 4 19 2 4 20 2 3 21 3 4 22 4 5 23 1 2 24 2 3 Arithmetic 2.78 3.70 mean

[0188] FIG. 3 depicts the results of the foam volume ranking 1-5 (1=low foam volume; 5=high foam volume) as listed in Table 5.

[0189] Formulation B containing 1 wt.-% 3-hydroxypropyl caprylate was voted to have higher foam volume (mean value 3.7) than the placebo formulation A without active (mean value 2.8, see Table 5 and FIG. 3 below).

TABLE-US-00006 TABLE 6 Results of evaluation (voting of 23 subjects for sample A or B to have higher foam volume) Number Formulation Formulation of subjects A B 23 2 21 % 8.7 91.3

[0190] FIG. 4 depicts the results of the evaluation (voting of 24 subjects for sample A or B to have higher foam volume).

[0191] It was demonstrated that the addition of 3-hydroxypropyl caprylate leads to higher foam formation in a hair and body wash formulation. 21 subjects out of a panel of 23 subjects voted that formulation B is the formula with the highest foam volume. Only 2 subjects voted that placebo formulation A has a higher foam volume.

3.) Sensory Assessment of 1 wt.-% Glyceryl Monocaprylate and 1 wt.-% 3-Hydroxypropyl Caprylate in o/w Emulsion Versus Placebo

[0192]

TABLE-US-00007 TABLE 7 Emulsion o/w used for sensory assessment INCI A1 A2 A3 Phase A Potassium Cetyl Phosphate, 2.0 2.0 2.0 Hydrogenated Palm Glycerides Pentaerythrityl Distearate 1.5 1.5 1.5 Glyceryl Stearate 2.0 2.0 2.0 Cetearyl Nonanoate 3.0 3.0 3.0 Caprylic/Capric/Triglceride 7.0 7.0 7.0 Ethylhexyl Isononanoate 3.0 3.0 3.0 Phase B Acrylates/C10-30 Alkyl 0.2 0.2 0.2 Acrylate Crosspolymer Xanthan Gum 0.2 0.2 0.2 Phase C Water (Aqua) 74.8 74.8 74.8 Disodium EDTA 0.1 0.1 0.1 Pentyleneglycol 1.0 1.0 1.0 1,2-Hexanediol, Caprylyl Glycol 0.6 0.6 0.6 Propylene Glycol 1.0 1.0 1.0 Glycerin 1.0 1.0 1.0 Phase D Sodium Hydroxide 10% aqueous sol. 0.6 0.6 0.6 Phase E Pentyleneglycol 1.0 1.0 1.0 Propylene Glycol 1.0 1.0 1.0 3-Hydroxypropyl Caprylate — 1.0 — Glyceryl Monocaprylate — — 1.0 Sum 100.0

[0193] Heat phase A and C separately up to 80° C. Disperse phase B in A (leading to AB). Add phase C to AB and emulsify using a HomoRex stirrer (5 min, 110 rpm). Add phase D and neutralize. Allow to cool by using a vane stirrer (10 min at 150 rpm, then 20 min at 100 rpm). Pre-dissolve the corresponding active ingredient together with pentylene glycol and propylene glycol and add to the emulsion by using a vane stirrer (10 min, 100 rpm, pH value 5.8).

Test Procedure of Sensory Assessment of 3-Hydroxypropyl Caprylate

[0194] 1 wt.-% of 3-hydroxypropyl caprylate was incorporated into the o/w emulsion according to table 7 (cf. sample A2).

[0195] 100 μl of the sample is applied on forearm. Sample is distributed with index and middle finger in rotary movements for 20 seconds. The first two parameters (Whitening and Absorption) are evaluated directly after distribution on a scale from 0-4.

[0196] Whitening: 0=not at all; 4=very strongly

[0197] Absorption: 0=very slow; 4=extremely speedily

[0198] Then the sample is applied on the other forearm and again distributed as described above. After 3 minutes the parameters (velvet/softness, acceptance and soaping) are evaluated on a scale from 0-4. The results of the evaluation are displayed in Table 8.

[0199] Soft/velvet/moisturized: 0=not at all; 4=very strong

[0200] Acceptance: 0=Dislike; 4=extremely good

[0201] Soaping: 0=not at all; 4=very strongly

TABLE-US-00008 TABLE 8 Results of sensory evaluation of 3-hydroxypropyl caprylate (10 untrained panelists) Soaping Absorption 3-Hydroxypropyl 3-Hydroxypropyl Placebo Caprylate 1 wt.-% Placebo Caprylate 1 wt.-% (A1) (A2) (A1) (A2) 0 0 1 1 3 1 0 3 3 2 1 2 1 1 0 0 3 1 0 1 1 0 1 3 2 1 1 3 3 1 2 2 3 1 1 2 2 1 1 3 Arithmetic   2.1   0.9   0.8   2.0 mean Soft Velvet/Moisturized Acceptance 3-Hydroxypropyl 3-Hydroxypropyl Placebo Caprylate 1 wt-% Placebo Caprylate 1 wt-% (A1) (A2) (A1) (A2) 2 2 2 2 2 1 1 2 2 1 2 2 1 2 0 0 4 1 3 1 0 3 1 3 1 2 1 2 1 3 0 2 2 4 1 2 1 3 0 2 Arithmetic   1.6   2.2   1.1   1.8 mean

[0202] It could be clearly demonstrated that the addition of 1 wt.-% of 3-hydroxypropyl caprylate leads to less soaping of the formulation and to a better absorption versus placebo (formulation A1 without active).

[0203] Furthermore, the subjects evaluated that the emulsion with 3-hydroxypropyl caprylate leads to a more soft and a more moisturized skin. The overall acceptance of the active containing emulsion A2 is better than that of placebo A1.

Test Procedure of Sensory Assessment of Glyceryl Monocaprylate

[0204] Samples A1 and A3 (cf. Table 7 above) are applied in a random order on one forearm each. Samples were distributed for 30 seconds with index and middle finger (5 seconds left arm, 5 seconds right arm). After 1 minute, the subjects were asked which sample shows a more caring/rich/moisturizing skin sensation on a scale from 0-4 (0=not at all; 4=very strong; cf. Table 9).

TABLE-US-00009 TABLE 9 Results of sensory evaluation of glyceryl monocaprylate (10 untrained panelists) Caring/Rich/Moisturizing 1 wt.-% Glyceryl Placebo Monocaprylate Panelist (A1) (A3)  1 2 1  2 1 4  3 2 3  4 1 2  5 1 2  6 1 3  7 3 2  8 2 4  9 2 4 10 3 4 Aritmetic mean   1.8   2.9

[0205] Most subjects voted that sample A3 with 1 wt.-% glyceryl monocaprylate has a more caring/rich/moisturized skin sensation.

4.) Sensory Assessment of 1 wt.-% 3-Hydroxypropyl Undecylenate in o/w Emulsion Versus Placebo

[0206]

TABLE-US-00010 TABLE 10 O/w emulsion B A (1 wt.-% INCI (Placebo) Active) Phase A Potassium Cetyl Phosphate, 2.00 2.00 Hydrogenated Palm Glycerides Pentaerythrityl Distearate 1.50 1.50 Glyceryl Stearate 2.00 2.00 Cetearyl Nonanoate 3.00 3.00 Caprylic/Capric/Triglceride 7.00 7.00 Ethylhexyl Isononanoate 3.00 3.00 Phase B Acrylates/C10-30 Alkyl Acrylate 0.20 0.20 Crosspolymer Xanthan Gum 0.20 0.20 Phase C Water (Aqua) 74.80 73.8 Disodium EDTA 0.10 0.10 Pentyleneglycol 1.00 1.00 1,2-Hexanediol, Caprylyl Glycol 0.60 0.60 Propylene Glycol 1.00 1.00 Glycerin 1.00 1.00 Phase D Sodium Hydroxide 10% aqueous 0.60 0.60 sol. Phase E Pentylene Glycol 1.00 1.00 Propylene Glycol 1.00 1.00 3-Hydroxypropyl Undecylenate — 1.0

Production Method:

[0207] Heat phase A and C separately up to 80° C. Disperse phase B in phase A. Add phase C to phase AB and emulsify using a HomoRex stirrer (3 min, 110 rpm). Add phase D and neutralize. Allow to cool by using a vane stirrer (10 min at 150 rpm, then 10 min at 100 rpm). Pre-dissolve 3-hydroxypropyl undecylenate with pentylene glycol and propylene glycol (phase E) and add to the emulsion by using a vane stirrer (10 min, 100 rpm).

Sensory Assessment:

[0208] Test design (for two samples; presented in random order) 100 μl of sample was applied on the forearm. Sample was distributed with index and middle finger in rotary movements for 20 seconds. Then the second sample is applied on the other forearm and again distributed. After 3 minutes the skin feel is evaluated.

Question to the panellists:

[0209] Which formulation (A or B) leaves the skin more soft and moisturized on a scale from 0-4? (Soft/moisture: 0=not at all; 4=very strong)

TABLE-US-00011 TABLE 11 Evaluation results with 10 panelists Soft/Moisturized Skin Feel 1 wt.-% 3-Hydroxypropyl Placebo (A) undecylenate (B) 1 3 3 2 2 3 2 3 2 3 2 3 1 3 1 2 2 3 2 3 Arithmetic mean 1.7 2.6* *significant versus placebo (P < 0.01)

[0210] It could be demonstrated that the addition of 3-hydroxypropyl undecylenate leads to a more soft and moisturized skin feel versus a placebo formulation without active.

5.) Formulation Examples

[0211]

TABLE-US-00012 TABLE 12 Composition of perfume oil 1 (PO1, Amounts in % b.w.) Ingredients Amount ALDEHYDE C14 SO-CALLED 2 ALLYL AMYL GLYCOLATE 10% DPG 5 ANISIC ALDEHYDE PURE 5 APPLE OLIFFAC TYPE 10 Benzylacetate 50 BERGAMOT IDENTOIL ® COLOURLESS 15 CANTHOXAL 5 CETALOX 10% IPM 3 CITRONELLOL 950 40 DAMASCENONE TOTAL 1% DPG 5 DAMASCONE ALPHA 10% DPG 5 DAMASCONE DELTA 10% DPG 2 DIMETHYL BENZYL CARBINYL BUTYRATE 2 DIPROPYLENE GLYCOL 178 EBANOL 2 ETHYL DECADIENOATE TRANS CIS-2,4 10% IPM 2 FLOROSA 5 FRAMBINON ® 10% DPG 7 GALAXOLIDE 50% IN IPM 100 GALBEX TYPE BASE 1 GERANYL ACETATE PURE 2 HEDIONE 30 HELIOTROPIN 10 HEXENYL ACETATE CIS-3 10% DPG 1 HEXENYL SALICYLATE CIS-3 5 HEXYL CINNAMIC ALDEHYDE ALPHA 70 HEXYL SALICYLATE 50 HYDROXY CITRONELLAL 10 ISO E SUPER 15 ISORALDEINE 70 20 LEAFOVERT ® 1 LILIAL 60 LINALOOL 60 LINALYL ACETATE 20 LYRAL 7 MANZANATE 2 PHENOXANOL 7 PHENYLETHYL ALCOHOL 120 SANDAL MYSORE CORE 2 SANDRANOL ® 7 STYRALYL ACETATE 3 TAGETES RCO 10% TEC 2 TERPINEOL PURE 20 TETRAHYDROGERANIOL 10% DPG 5 TONALIDE 7 VERTOCITRAL 10% DPG 5 VERTOFIX 15 Total 1000

TABLE-US-00013 TABLE 13 Composition of perfume oil 2 (PO2, Amounts in % b.w.) Ingredients Amount Acetophenone, 10% in DPG 10 n-Undecanal 5 Aldehyde C14, so-called (peach aldehyde) 15 Allylamyl glycolate, 10% in DPG 20 Amyl salicylate 25 Benzyl acetate 60 Citronellol 80 d-Limonene 50 Decenol trans-9 15 Dihydromyrcenol 50 Dimethylbenzylcarbinyl acetate 30 Diphenyloxide 5 Eucalyptol 10 Geraniol 40 Nerol 20 Geranium oil 15 Hexenol cis-3, 10% in DPG 5 Hexenyl salicylate cis-3 20 Indole, 10% in DPG 10 Alpha-ionone 15 Beta-ionone 5 Lilial ® (2-methyl-3-(4-tert-butyl-phenyl)propanal) 60 Linalool 40 Methylphenyl acetate 10 Phenylethyl alcohol 275 Styrolyl acetate 20 Terpineol 30 Tetrahydrolinalool 50 Cinnamyl alcohol 10 Total: 1000

TABLE-US-00014 TABLE 14 Composition of perfume oil 3 (PO3, Amounts in % b.w.) Ingredients Amount Benzyl acetate 60 Citronellyl acetate 60 Cyclamenaldehyde (2-methyl-3-(4-isopropylphenyl) 20 propanal Dipropylene glycol (DPG) 60 Ethyllinalool 40 Florol (2-isobutyl-4-methyltetrahydro-2H-pyran-4-ol) 30 Globanone ® [(E/Z)-8-cyclohexadecen-1-one] 180 Hedione ® (methyldihydrojasmonate) 140 Hexenyl salicylate, cis-3 10 Vertocitral (2,4-dimethyl-3-cyclohexenecarboxaldehyde) 5 Hydratropaldehyde, 10% in DPG 5 Isodamascone (1-(2,4,4-trimethyl-2-cyclohexen-1-yl)- 5 2-buten-1-one, 10% in DPG Isomuscone (cyclohexadecanone) 40 Jacinthaflor (2-methyl-4-phenyl-1,3-dioxolane) 10 Cis-jasmone, 10% in DPG 20 Linalool 50 Linalyl acetate 30 Methyl benzoate, 10% in DPG 25 para-Methyl cresol, 10% in DPG 10 Nerol 20 Phenylpropylaldehyde 5 2-Phenylethyl alcohol 82 Tetrahydrogeraniol 13 2,2-Dimethyl-3-cyclohexyl-1-propanol 80 Total: 1000

TABLE-US-00015 TABLE 15 Composition of perfume oil 4 (PO4, Amounts in % b.w.) Ingredients Amount AMBRETTOLIDE (MACRO) 10 AMBROXIDE 10% in IPM 10 BENZYL ACETATE 20 BENZYL SALICYLATE 15 BERGAMOT OIL. bergapten-free 60 CALONE ® 1951 10% in DPG 15 COUMARIN 5 CYCLOGALBANATE ® 10% in DPG 10 ALPHA-DAMASCONE 1% in DPG 20 DIHYDROMYRCENOL 10 ETHYL LINALOOL 75 ETHYL LINALYLACETATE 50 ETHYL MALTOL 1% in DEP 10 ETHYLENE BRASSYLATE (MACRO) 80 FLOROSA 40 GERANYLACETATE 10 HEDIONE ® HC/30 35 HEDIONE ® 210 HELIONAL ® 15 HELVETOLIDE ® (ALICYC) 30 HEXENYLSALICYLATE CIS-3 20 ISO E SUPER ® 40 LEAFOVERT ® 10% in DEP 10 LILIAL ® 80 LYRAL ® 20 MANDARIN OIL 10 STYRALYL ACETATE 5 SYMROSE ® 15 VANILLIN 10% in DEP 20 DIPROPYLENE GLYCOL (DPG) 50 TOTAL 1000

TABLE-US-00016 TABLE 16 Composition of perfume oil 5 (PO5, Amounts in % b.w.) Ingredients Amount AMAROCITE ® 10 AMBROCENIDE ® 10% in DPG 5 AMBROXIDE 15 AURELIONE ® (7/8-Cyclohexadecenone) (MACRO) 70 BERGAMOT OIL. bergapten-free 90 CALONE ® 1951 10% in DPG 20 CARAWAY OIL 10 CITRAL 20 COUMARIN 10 ALPHA-DAMASCONE 1% in DPG 15 DIHYDROMYRCENOL 70 ESTRAGON OIL 10 ETHYL LINALOOL 100 ETHYL LINALYLACETATE 90 EUGENOL 10 EVERNYL ® 5 FRUCTATE ® 5 GERANIUM OIL 5 HEDIONE ® HC/30 100 HELIONAL ® 10 INDOLE 10% in DPG 5 ISO E SUPER ® 100 KEPHALIS ® 5 LAVENDER OIL 40 CITRUS OIL 80 LILIAL ® 30 MANDARIN OIL 20 MUSCENONE (MACRO) 5 SANDRANOL ® 10 VANILLIN 10% in DPG 5 DIPROPYLENE GLYCOL 30 TOTAL 1000

[0212] The perfume oils PO1, PO2, PO3, PO4, or PO5 from the above examples were worked separately in each case into the formulations presented below.

[0213] Cosmetic formulations (compositions)—amounts are indicated as % by weight for all formulations.

TABLE-US-00017 TABLE 17 Cream o/w Ingredients INCI Amount Dracorin ® CE Glyceryl Stearate Citrate 1.0 Lanette ® O Cetearyl Alcohol 2.0 Cutina ® GMS-V Glyceryl Stearate 1.0 Tegosoft ® MM Myristyl Myristate 1.0 Xiameter ® PMX-0246, Cyclohexasiloxane (and) 0.5 Cyclosiloxane Cyclopentasiloxane Dragoxat ® 89 Ethylhexyl Isononanoate 2.0 PCL-Liquid 100 Cetearyl Ethylhexanoate 4.0 Neutral Oil Caprylic/Capric Triglyceride 4.0 Carbopol ® Ultrez 21 Acrylates/C10-30 Alkyl 0.2 Acrylate Crosspolymer Keltrol ® CG-T Xanthan Gum 0.1 Water Water (Aqua) ad 100 Glycerol 99, 5 P. Glycerol 3.0 1,2-Propylene Glycol 99 Propylene Glycol 2.0 P GC Sodium Benzoate Sodium Benzoate 0.1 Sodium Hydroxide 10% Sodium Hydroxide 0.5 solution Perfume oil PO1, PO2, Perfume 0.3 PO3, PO4, or PO5 Euxyl ® K702 Dehydroacetic Acid, Benzoic 0.3 Acid, Phenoxyethanol, Polyaminopropyl Biguanide, Ethylhexylglycerin 3-Hydroxypropyl Hydroxypropyl caprylate 0.3 caprylate 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate

TABLE-US-00018 TABLE 18 Hand and body cream Ingredients INCI Amount Dracorin ® GOC Glyceryl Oleate Citrate, 2.0 Caprylic/Capric Triglyceride PCL-Solid Stearyl Heptanoate, Stearyl 2.5 Caprylate Lanette ® O Cetearyl Alcohol 1.5 Cutina ® GMS-V Glyceryl Stearate 1.0 Dragoxat ® 89 Ethylhexyl Isononanoate 3.0 PCL-Liquid 100 Cetearyl Ethylhexanoate 7.0 Isodragol ® Triisononanoin 4.0 Xiameter ® PMX-0345 Cyclopentasiloxane (and) 0.5 Cyclosiloxane Cyclohexasiloxane Water Water (Aqua) ad 100 Carbopol ® Ultrez 21 Acrylates/C10-30 Alkyl 0.2 Acrylate Crosspolymer Keltrol ® CG-RD Xanthan Gum 0.1 Glycerol 85 P. Glycerol 3.0 DragoBetaGlucan Water (Aqua), Butylene 1.5 Glycol, Glycerol, Avena Sativa (Oat) Kernel Extract Potassium Sorbat Potassium Sorbate 0.1 Sodium Hydroxide 10% Sodium Hydroxide 0.5 solution Perfume oil PO1, PO2, Fragrance 0.2 PO3, PO4, or PO5 Euxyl ® K300 Methyl-, Butyl-, Ethyl-, 0.3 Propyl, Isobutylparaben, Phenoxyethanol 3-Hydroxypropyl Hydroxypropyl caprylate 0.2 caprylate Glyceryl monocaprylate Glyceryl caprylate 0.05

TABLE-US-00019 TABLE 19 Daily face cream SPF 20 Ingredients Amount SymOcide PH 1 Phenoxyethanol, Hydroxyacetophenone, Caprylyl Glycol, Water (Aqua) Ascorbyl Palmitate 0.1 Ascorbyl Palmitate Biotive L-Arginine 0.2 Arginine Buriti oil 1 Mauritia Flexuosa Fruit Oil Cocoa butter 2 Theobroma Cacao (Cocoa) Seed Butter Dimethicone 0.5 Dimethicone Disodium EDTA 0.1 Disodium EDTA Dragosantol 100 0.1 Bisabolol Dragoxat 89 5 Ethylhexyl Isononanoate Emulsiphos 2 Potassium Cetyl Phosphate, Hydrogenated Palm Glycerides Extrapone Corail 1 Glycerin, Aqua, Hydrolyzed Corallina Officinalis Glycerin 3 Glycerin Isoadipate 5 Diisopropyl Adipate Jojoba Wax Flakes 1 Hydrogenated Jojoba Oil Keltrol CG-T 0.1 Xanthan Gum Lanette O 5 Cetearyl Alcohol Lanette 16 1 Cetyl Alcohol Lanette 22 1 Behenyl Alcohol Neo Heliopan 357 3 Butyl Methoxydibenzoylmethane Neo Heliopan HMS 10 Homosalate Neo Heliopan Hydro used as a 25% aq. Solution 8 neutralized by arginine Phenylbenzimidazole Sulfonic Acid Neo Heliopan OS 5 Ethylhexyl Salicylate Orgasol Caresse 1 Polyamide-5 Perfume oil PO1, PO2, PO3, PO4, or PO5 0.1 Shea butter 3 Butyrospermum Parkii (Shea) Butter Simugel EG 1 Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Polysorbate 80 SymFinity 1298 0.1 Echinacea Purpurea Extract SymMatrix 0.1 Maltodextrin, Rubus Fructicosus (Blackberry) Leaf Extract SymSitive 1609 1 Pentylene Glycol, 4-t-Butylcyclohexanol Tegosoft TN 4 C12-15 Alkyl Benzoate 3-Hydroxypropyl caprylate 0.3 Glyceryl monoundecylenate 0.1 Water ad 100 Aqua

TABLE-US-00020 TABLE 20 w/o night cream Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Aloe Vera Gel Concentrate Water (Aqua), Aloe Barbadensis 3.0 10/1 * Leaf Juice Alugel 34 TH Aluminium Stearate 1.0 Dragosan W/O P* Sorbitan Isostearate, Hydrogenated 6.0 Castor Oil, Ceresin, Beeswax (Cera Alba) Dragosantol ® 100* Bisabolol 0.2 Extrapone ® Witch Hazel Propylene Glycol, Hamamelis 1.0 Distillate colourless Virginiana (Witch Hazel) Water, Water (Aqua), Hamamelis Virginiana (Witch Hazel) Extract Perfume oil PO1, PO2, Fragrance 0.4 PO3, PO4, or PO5 Glycerol 85% Glycerin 2.0 Karion F Sorbitol 2.0 Magnesium Chloride Magnesium Chloride 0.7 PCL Liquid 100 Cetearyl Ethylhexoate 12.0 Retinyl Palmitate in Oil Retinyl Palmitate 0.2 Sun Flower Oil Helianthus Annuus (Sunflower) 5.0 Seed Oil Sweet Almond Oil Prunus dulcis 5.0 SymMatrix ® Maltodextrin, Rubus Fruticosus 1.0 (Blackberry) Leaf Extract SymOcide PS Phenoxyethanol, Decylene glycol, 1.0 1,2-Hexanediol SymVital ® AgeRepair Zingiber Officinale (Ginger) Root 0.1 Extract Tocopherol Acetate Tocopheryl Acetate 3.0 Water (demineralized) Water (Aqua) ad 100

TABLE-US-00021 TABLE 21 Body lotion Ingredients Amount Cetearyl Alcohol 2.0 Ethylhexyl Isononanoate 5.0 Cetearyl Ethylhexanoate, Isopropyl Myristate 3.0 Glyceryl Oleate Citrate, Caprylic/Capric Triglyceride 4.0 Water (Aqua) ad 100 Carbomer 0.3 Sodium Benzoate 0.1 Propylene Glycol 5.0 Sodium Hydroxide 30% solution 0.3 Perfume oil PO1, PO2, PO3, PO4, or PO5 0.3 Triethylene Glycol, Imidazolidinyl Urea, Methylparaben, Propyl- 0.3 paraben, Dehydroacetic Acid 3-Hydroxypropyl caprylate 0.2 3-Hydroxypropyl undecylenate 0.2

TABLE-US-00022 TABLE 22 Antibacterial body lotion, sprayable Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.05 2,4-Hexadienoic acid, Sorbic acid, potassium salt 0.2 potassium salt Dow Corning 345 Fluid Cyclomethicone 0.5 Dracorin ® GOC Glyceryl Oleate Citrate, 2.0 Caprylic/Capric Triglyceride Drago-Calm Water, Glycerin, Avena Sativa 1.0 (Oat) Kernel Extract Dragosantol ® 100* Bisabolol 0.1 Perfume oil PO1, PO2, Fragrance 0.3 PO3, PO4, or PO5 Hydrolite ®-5 Pentylene Glycol 5.0 Neutral Oil Caprylic/Capric Triglyceride 4.0 Paraffin Oil Mineral Oil 4.0 PCL Liquid 100 Cetearyl Ethylhexoate 7.0 Pemulen TR-2 Acrylates/C10-30 Alkyl 0.2 Acrylate Crosspolymer Sodium Hydroxide (10% Sodium Hydroxide 0.4 sol.) SymDeo ® MPP Dimethyl Phenylbutanol 0.5 SymRelief  ® 100 Bisabolol, Zingiber Officinale 0.1 (Ginger) Root Extract Water (demineralized) Water (Aqua) ad 100

TABLE-US-00023 TABLE 23 Aseptic wound cream Ingredients Amount Sorbitan Isostearate, Hydrogenated Castor 6.0 Oil, Ceresin, Beeswax (Cera Alba) Petrolatum 21.0 Cera Alba 5.0 Cetearyl Alcohol 7.0 Prunus Dulcis 7.0 Lanolin 5.0 Paraffinum Liquidum 12.0 Perfume oil PO1, PO2, PO3, PO4, or PO5 0.3 Water (Aqua) ad 100 Panthenol 7.0 Magnesium Sulfate 0.7 Pentylene Glycol 1.0 Tocopheryl Acetate 1.0 Octenidine dihydrochloride 0.1 Phenoxyethanol 0.5 3-Hydroxypropyl caprylate 0.4 Glyceryl monocaprylate 0.2

TABLE-US-00024 TABLE 24 Anti acne balm Ingredients INCI Amount 3-Hydroxypropyl Hydroxypropyl caprylate 0.3 caprylate 3-Hydroxypropyl Hydroxypropyl undecylenate 0.2 undecylenate Abil 350 Dimethicone 1.0 Allantoin Allantoin 0.1 Aloe Vera Gel Water (Aqua), Aloe 3.0 Concentrate 10/1 * Barbadensis Leaf Juice Azelaic Acid Azelaic Acid 5.0 Cetiol OE Dicaprylyl Ether 4.0 Cetiol SB 45 Butyrospermum Parkii (Shea Butter) 1.0 D-Panthenol Panthenol 1.0 Emulsiphos ® Potassium Cetyl Phosphate, 2.0 Hydrogenated Palm Glycerides Perfume oil PO1, PO2, Fragrance 0.2 PO3, PO4, or PO5 Frescolat ®ML cryst. Menthyl Lactate 0.8 Glycerol 85% Glycerin 4.0 Hydroviton ® PLUS Water, Pentylene Glycol, Glycerin, 1.0 Fructose, Urea, Citric Acid, Sodium Hydroxide, Maltose, Sodium PCA, Sodium Chloride, Sodium Lactate, Trehalose, Allantoin, Sodium hyaluronate, Glucose Lara Care A-200 Galactoarabinan 0.3 Pemulen TR-2 Acrylates/C10-30 Alkyl Acrylate 0.2 Crosspolymer Sodium Hydroxide Sodium Hydroxide 0.4 (10% sol.) SymOcide PH Hydroxyacetophenone, 1.0 Phenoxyethanol, Caprylyl glycol, Aqua Tegosoft TN C12-15 Alkyl Benzoate 5.0 Tocopherol Acetate Tocopheryl Acetate 0.5 Water (demineralized) Water (Aqua) ad 100

TABLE-US-00025 TABLE 25 Barrier repair cream Ingredients INCI Amount 3-Hydroxypropyl Hydroxypropyl caprylate 0.1 caprylate Glyceryl Glyceryl caprylate 0.1 monocaprylate 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Glyceryl Glyceryl undecylenate 0.1 monoundecylenate Abil 350 Dimethicone 0.5 Allantoin Allantoin 0.25 Ceramide BIO* Cetylhydroxproline 0.5 Palmitamide Dracorin ® CE Glyceryl Stearate Citrate 1.5 Dragoxat ® 89 Ethylhexyl Ethylisononan-oate 2.0 Emulsiphos ® Potassium Cetyl Phosphate, 2.0 Hydrogenated Palm Glycerides Extrapone ® Glycerin, Water 0.5 Rosemary GW (Aqua), Rosmarinus officinalis (Rosemary) Leaf Extract Perfume oil PO1, Fragrance 0.1 PO2, PO3, PO4, or PO5 Glycerol 85% Glycerin 3.0 Glyceryl Stearate Glyceryl Stearate 2.0 Hydroviton ® 24 Water, Glycerin, 1.0 Sodium Lactate, TEA Lactate, Serine, Lactic Acid, Urea, Sorbitol, Sodium Chloride, Lauryl Diethylenedi-aminoglycine, Lauryl Aminopropyl-glycine, Allantoin Isodragol ® Triisononanoin 3.0 Lanette O Cetearyl Alcohol 2.0 NaOH 10% sol. Sodium Hydroxide 0.3 Neutral Oil Caprylic/Capric Triglyceride 10.0 SymCalmin ® Pentylene Glycol, Butylene Glycol, 1.0 Hydroxyphenyl Propamidobenzoic Acid SymRepair ® 100 Hexyldecanol, Bisabolol, 2.0 Cetylhydroxyproline Palmitamide, Stearic Acid, Brassica Campestris (Rapeseed) Sterols SymTriol Caprylyl glycol, 1,2-Hexanediol, 1.0 Methylbenzyl alcohol Tegosoft PC 31 Polyglyceryl 3-Caprate 0.3 Tocopherol Acetate Tocopheryl Acetate 0.3 Water Water (Aqua) ad 100 (demineralized)

TABLE-US-00026 TABLE 26 Skin soothing lotion Ingredients INCI Amount 3-Hydroxypropyl Hydroxypropyl caprylate 0.3 caprylate Glyceryl monocaprylate Glyceryl caprylate 0.05 3-Hydroxypropyl Hydroxypropyl undecylenate 0.2 undecylenate Glyceryl Glyceryl undecylenate 0.05 monoundecylenate Abil 350 Dimethicone 2.0 Allantoin Allantoin 0.2 Carbopol Ultrez-10 Carbomer 0.1 Ceramide BIO* Cetylhydroxyproline Palmitamide 0.1 Citric Acid 10% sol. Citric Acid 0.4 Emulsiphos ® Potassium Cetyl Phosphate, 2.0 Hydrogenated Palm Glycerides Extrapone ® Green Glycerin, Water (Aqua), Camellia 0.2 Tea GW Sinensis Leaf Extract Extrapone ® Rosemary Glycerin, Water (Aqua), Rosmarinus 0.3 GW officinalis (Rosemary) Leaf Extract Perfume oil PO1, PO2, Fragrance 0.3 PO3, PO4, or PO5 Glycerol 85% Glycerin 2.0 Glyceryl Stearate Glyceryl Stearate 2.0 Isodragol ® Triisononanoin 2.0 Keltrol RD Xanthan Gum 0.1 Lanette O Cetearyl Alcohol 3.0 Neo PCL wssl. N Trideceth-9, PEG-5 Ethylhexanoate, 1.0 Water PCL Liquid 100 Cetearyl Ethylhexanoate 5.0 PCL Solid Stearyl Heptanoate, Stearyl Caprylate 2.0 Propylene Glycol Propylene Glycol 5.0 Sodium Hydroxide Sodium Hydroxide 0.3 (10% sol.) SymCalmin ® Pentylene Glycol, Butylene Glycol, 2.0 Hydroxyphenyl Propamidobenzoic Acid SymMatrix ® Maltodextrin, Rubus Fruticosus 0.1 (Blackberry) Leaf Extract SymSave H Hydroxyacetophenone 0.4 2-Phenoxyethyl Alcohol Phenoxyethanol 0.4 SymSitive ®1609 Pentylene Glycol, 4-t- 1.5 Butylcyclohexanol Water (demineralized) Water (Aqua) ad 100

TABLE-US-00027 TABLE 27 Baby Nappy Rash Cream w/o Ingredients Amount SymOcide PH 1 Phenoxyethanol, Hydroxyacetophenone, Caprylyl Glycol, Water (Aqua) Cupuaçu butter 1 Theobroma Grandiflorum Seed Butter Cutina HR Powder 1.5 Hydrogenated Castor Oil Dehymuls PGPH 5 Polyglyceryl-2 Dipolyhydroxystearate Glycerin 5 Glycerin Jojoba oil 5 Simmondsia Chinensis (Jojoba) Seed Oil Magnesium Sulfate Hepta Hydrate 0.5 Magnesium Sulfate Monomuls 90-O18 1 Glyceryl Oleate Neutral oil 8 Caprylic/capric triglyceride PCL Liquid 100 5 Cetearyl Ethylhexanoate SymCalmin 1 Butylene Glycol, Pentylene Glycol, Hydroxyphenyl Propamidobenzoic Acid Tamanu oil 0.2 Calophyllum Inophyllum Seed Oil Tetrasodium EDTA 0.1 Tetrasodium EDTA Titan dioxide 4 Titan dioxide Water ad 100 Aqua Wheat germ oil 2 Triticum Vulgare (Wheat) Germ Oil Zinc oxide 10 Zinc oxide 3-Hydroxypropyl caprylate 0.3 3-Hydroxypropyl undecylenate 0.15

TABLE-US-00028 TABLE 28 Skin lightening day cream o/w Ingredients INCI Amount 3-Hydroxypropyl Hydroxypropyl caprylate 0.1 caprylate Glyceryl monocaprylate Glyceryl caprylate 0.1 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate Glyceryl Glyceryl undecylenate 0.05 monoundecylenate Abil 350 Dimethicone 0.5 Dracorin ® CE Glyceryl Stearate Citrate 2.5 Dracorin ® GOC Glyceryl Oleate Citrate, 0.5 Caprylic/Capric Triglyceride Drago-Beta-Glucan Water (Aqua), Butylene 0.3 Glycol, Glycerin, Avena Sativa (Oat), Kernel Extract Dragosantol ® 100* Bisabolol 0.2 Perfume oil PO1, PO2, Fragrance 0.1 PO3, PO4, or PO5 Frescolat ® MGA Menthone Glycerol Acetal 0.5 Glycerol 85% Glycerin 3.0 Isopropyl Palmitate Isopropyl Palmitate 4.0 Keltrol RD Xanthan Gum 0.2 Lanette 16 Cetyl Alcohol 1.0 Neo Heliopan ® AV Ethylhexyl Methoxy-cinnamate 5.0 Neutral Oil Caprylic/Capric Triglyceride 6.0 PCL Liquid 100 Cetearyl Ethylhexoate 3.0 Sodium Benzoate Sodium Benzoate 0.1 Symdiol ®68T 1,2-Hexanediol, Caprylylglycol, 0.5 Tropolone SymVital ® AgeRepair Zingiber Officinale 0.1 (Ginger) Root Extract SymWhite ®377 Phenylethyl Resorcinol 0.5 Water (demineralized) Water (Aqua) ad 100

TABLE-US-00029 TABLE 29 Shampoo Ingredients Amount 4-Hydroxyacetophenone (SymSave H) 0.3 Hydroxyacetophenone Antil 127 0.5 PEG-120 Methyl Glucose Dioleate Brazilian nut oil 0.5 Bertholletia Excelsa Seed Oil Cocamidopropyl Betaine 38% 5 Cocamidopropyl Betaine Octopirox 0.3 Piroctone olamine Dragoderm 0.5 Glycerin, Triticum Vulgare Gluten, Aqua Fragrance 0.5 Perfum Glycerin 0.5 Glycerin Jojoba oil 0.5 Simmondsia Chinensis (Jojoba) Seed Oil Marlinat 242/90M 15 MIPA Laureth Sulfate, Propylene Glycol Marlowet CG 2 PEG-18 Castor Oil Dioleate Plantacare 1200 UP 0.5 Lauryl Glucoside Polyquaternium-10 0.3 Polyquaternium-10 Sodium Chloride 1.5 Sodium Chloride SymCalmin 1 Butylene Glycol, Pentylene Glycol, Hydroxyphenyl Propamidobenzoic Acid SymOcide PS 0.8 Phenoxyethanol, Decylene Glycol,1,2-Hexanediol 3-Hydroxypropyl caprylate 0.4 3-Hydroxypropyl undecylenate 0.2 Water ad 100 Aqua

TABLE-US-00030 TABLE 30 Anti dandruff shampoo Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.3 Glyceryl monocaprylate Glyceryl caprylate 0.2 3-Hydroxypropyl Hydroxypropyl undecylenate 0.15 undecylenate Aloe Vera Gel Concentrate Water (Aqua), Aloe Barbadensis 0.5 10/1 * Leaf Juice Avocado oil Persea Gratissima (Avocado) Oil 0.5 Citric Acid 10% sol. Citric Acid 0.3 Comperlan 100 Cocamide MEA 0.5 Crinipan AD Climbazole 0.2 Dragoderm ® Glycerin, Triticum Vulgare 2.0 (Wheat) Gluten, Water (Aqua) Perfume oil PO1, PO2, Fragrance 0.5 PO3, PO4, or PO5 Genapol LRO liquid Sodium Laureth Sulfate 37.0 Merquat 550 Polyquaternium-7 0.5 Sodium Chloride Sodium Chloride 1.0 SymSave ® H Hydroxyacetophenone 0.8 Tego Betain L7 Cocamidopropyl Betaine 6.0 Water (demineralized) Water (Aqua) ad 100

TABLE-US-00031 TABLE 31 2-in-1 Shampoo Ingredients INCI Name Amount Deionized water Water ad 100 Shea butter Butyrospermum Parkii 0.1 (Shea) Butter Plantacare PS 10 Sodium Laureth Sulfate, Lauryl 20.0 Glucoside Euperlan PK 771 Glycol Distearate, Sodium Lauryl 6.0 Sulfate, Cocamide MEA, Laureth-10 Sodium chloride Sodium Chloride 1.4 Citric acid monohydrate Citric acid 0.1 crystalline Perfume oil PO1, PO2, Fragrance 0.5 PO3, PO4, or PO5 Phenoxyethanol, Phenoxyethanol, Methylparaben, 0.5 Methylparaben, Ethylparaben Ethylparaben Zinc Omadine Zinc pyrithione 0.10 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.3 3-Hydroxypropyl Hydroxypropyl undecylenate 0.15 undecylenate

TABLE-US-00032 TABLE 32 Body wash Ingredients INCI Amount Lumerol K 28 Disodium Laureth Sulfosuccinate, 33.0 Cocamidopropyl Betaine, Magnesium Lauryl Sulfate Amphotensid B 4 Cocamidopropyl Betaine 10.0 Perlglanzmittel GM 4055 MIPA-Pareth-25 Sulfate, Glycol 4.0 Stearate Sodium Chloride Sodium Chloride 2.0 Avocado oil Persea Gratissima (Avocado) Oil 3.0 SymSave H Hydroxyacetophenone 0.8 Water Water ad 100 Perfume oil PO1, PO2, Fragrance 0.5 PO3, PO4, or PO5 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.1

TABLE-US-00033 TABLE 33 Shower gel Ingredients INCI Amount Deionized water Water ad 100 Shea butter Butyrospermum Parkii 1.0 (Shea) Butter Plantacare PS 10 Sodium Laureth Sulfate, 20.0 Lauryl Glucoside Dehydroacetic acid Dehydroacetic acid 0.2 SymSave H Hydroxyacetophenone 0.3 Sodium chloride Sodium Chloride 1.4 Citric acid monohydrate Citric Acid 1.3 crystalline Perfume oil PO1, PO2, Fragrance 0.6 PO3, PO4, or PO5 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.1 Glyceryl monocaprylate Glyceryl caprylate 0.3 3-Hydroxypropyl Hydroxypropyl undecylenate 0.2 undecylenate

TABLE-US-00034 TABLE 34 Intimate wash Ingredients INCI Amount Tegobetaine HS Cocamidopropyl Betaine, 15.0 Glyceryl Laurate Tagat L 2 PEG-20 Glyceryl Laurate 2.0 Arlacide G Chlorhexidine Digluconate 0.1 Rewoquat B 50 Benzalkonium Chloride 0.1 Lactic Acid, 80% Lactic Acid 0.1 euxyl ® K700 Potassium Sorbate, Benzyl 0.3 Alcohol, Phenoxyethanol Water Water ad 100 Perfume oil PO1, PO2, Fragrance 0.2 PO3, PO4, or PO5 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.3 Glyceryl monocaprylate Glyceryl caprylate 0.1 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.05

TABLE-US-00035 TABLE 35 Liquid soap, transparent Ingredients INCI Amount Tagat O 2 PEG-20 Glyceryl Oleate 2.5 Coconut oil diethanolamine Cocamide DEA 5.0 condensate Abil B 8842 Cyclomethicone 0.5 Sodium laurylethersulfate, Sodium Laureth Sulfate 35.0 28% Tego-Betaine L7 Cocamidopropyl Betaine 5.0 Soap, 25% Coconut acid, Potassium salt, 20.0 Potassium Oleate Perfume oil PO1, PO2, Fragrance 0.4 PO3, PO4, or PO5 Preservative DMDM Hydantoin 0.2 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 Water Water ad 100

TABLE-US-00036 TABLE 36 Syndet soap, liquid Ingredients INCI Amount Elfan OS 46 Sodium Olefin C14-C16 Sulfonate 35.5 Armoteric LB Lauryl Betaine 8.0 Euperlan PK 3000 OK Glycol Distearate, 10.0 Glycerin, Laureth- 4, Cocamidopropyl Betaine Elfacos GT 282 L Talloweth-60 Myristyl Glycol 3.0 PCL-Liquid 100 Cetearyl Ethylhexanoate 4.0 Perfume oil PO1, PO2, Fragrance 0.4 PO3, PO4, or PO5 SymSave H 4-Hydroxyacetophenone 0.6 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.25 undecylenate Water Water ad 100

TABLE-US-00037 TABLE 37 Anti-acne wash Ingredients Amount Water (Aqua) ad 100 Polyquaternium-7 0.5 Cocamidopropyl Betaine 9.0 Coco Glucoside 2.0 Polysorbate 80, Glycerol, 1.0 Gossypium Herbaceum, (Cotton) Seed Oil, Water (Aqua) Trideceth-9, PEG-5 Ethylhexanoate, Water (Aqua) 1.0 Glycereth-90 Isostearate, Laureth-2 0.5 Sodium Laureth Sulfate 37.0 Glycerol, Triticum Vulgare (Wheat) Gluten, Water (Aqua) 1.0 Sodium Chloride 0.3 Perfume oil PO1, PO2, PO3, PO4, or PO5 1.0 SymOcide BHO (Hydroxyacetophenone, 1.0 Benzyl alcohol, Caprylyl glycol, Water) 3-Hydroxypropyl caprylate 0.25 3-Hydroxypropyl undecylenate 0.15

TABLE-US-00038 TABLE 38 Mineral wash and cleaning gel Ingredients INCI Amount Water Water (Aqua) ad 100 Pionier ® NP 37 G Sodium Carbomer 1.5 SymSol ® PF-3 Water (Aqua), Pentylene Glycol, 5.0 Sodium Lauryl Sulfoacetate, Sodium Oleoyl Sarcosinate, Sodium Chloride, Disodium Sulfoacetate, Sodium Oleate, Sodium Sulfate Hydroviton ® 24 Water (Aqua), Pentylene Glycol, 1.0 Glycerol, Sodium Lactate, Lactic Acid, Serine, Urea, Sorbitol, Sodium Chloride, Allantoin Extrapone ® Silk GW Water (Aqua), Glycerol, Hydrolyzed Silk 1.0 Hydrolite ® 5 Pentylene Glycol 4.0 Actipearls Red Star # Water (Aqua), Propylene Glycol, Algin, 1.0 DH10402/6 Gellan Gum, Xanthan Gum, CalciumChloride, CI 12490 (Pigment Red 5), Mica (CI 77019), Titanium Dioxide (CI 77891) Perfume oil PO1, Fragrance 0.5 PO2, PO3, PO4, or PO5 SymGuard CD Phenylpropanol, o-cymen-5-ol, 0.3 Decylene glycol 3-Hydroxypropyl Hydroxypropyl caprylate 0.2 caprylate 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate

TABLE-US-00039 TABLE 39 After Shave Tonic Ingredients INCI Amount SymSol ® PF-3 Water (Aqua), Pentylene Glycol, 3.0 Sodium Lauryl Sulfoacetate, Sodium Oleoyl Sarcosinate, Sodium Chloride, Disodium Sulfoacetate, SodiumOleate, Sodium Sulfate SymSitive ® 1609 Pentylene Glycol, 4-t- 1.0 Butylcyclohexanol Frescolat ® ML Menthyl Lactate 0.3 Glycerol 99, 5 P. Glycerol 5.0 Water Water (Aqua) ad 100 Extrapone ® Glacier Glycerol, Water (Aqua) 1.0 Water GW SymCalmin ® Butylene Glycol, Pentylene Glycol, 0.5 Hydroxyphenyl Propamidobenzoic Acid Dragosine ® Carnosine 0.1 Hydrolite ® 5 Pentylene Glycol 5.0 Ethanol 96% Alcohol Denat. 5.0 Colour Pigment Colour Pigment 0.05 Perfume oil PO1, Fragrance 0.15 PO2, PO3, PO4, or PO5 3-Hydroxypropyl Hydroxypropyl caprylate 0.1 caprylate 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate

TABLE-US-00040 TABLE 40 Hair conditioner with Crinipan, rinse-off Ingredients INCI Amount Lanette ® O Cetearyl Alcohol 4.0 Dragoxat 89 Ethylhexyl Isononanoate 2.0 Genamin ® KDM-P Behentrimonium Chloride 1.0 SF 1550 Phenyl Trimethicone 0.1 Neo Heliopan ® BB Benzophenone-3 0.1 Crinipan ® AD Climbazole 0.4 Glycerol 99, 5 P. Glycerol 6.0 Water Water (Aqua) ad 100 Actipone ® Water (Aqua), Butylene Glycol, Malic 0.5 Alpha Pulp Acid, Actinidia Chinensis (Kiwi) Fruit Juice, Citrus Aurantium Dulcis (Orange) Juice, Citrus Paradisi (Grapefruit) Juice, Pyrus Malus (Apple) Juice, Trideceth-9, Prunus Amygdalus Dulcis (Sweet Almond) Seed Extract Extrapone ® Propylene Glycol, Water (Aqua), 0.5 Bamboo P Butylene Glycol, Bambusa Vulgaris Shoot Extract Sodium Hydroxide Sodium Hydroxide 0.4 10% solution Colour I Colour 0.6 Colour II Colour 0.3 Perfume oil PO1, Fragrance 0.4 PO2, PO3, PO4, or PO5 Preservative Methylparaben 0.3 3-Hydroxypropyl Hydroxypropyl caprylate 0.15 caprylate Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.15 undecylenate

TABLE-US-00041 TABLE 41 Scalp soothing hair conditioner with UV-B/UV-A protection, rinse off Ingredients INCI Amount 3-Hydroxypropyl Hydroxypropyl caprylate 0.2 caprylate Glyceryl monocaprylate Glyceryl caprylate 0.2 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Glyceryl Glyceryl undecylenate 0.1 monoundecylenate Abil 350 Dimethicone 0.1 Dehyquart A CA Cetrimonium Chloride 0.5 Dehyquart SP Quaternium-52 4.0 Dracorin ® CE Glyceryl Stearate Citrate 1.0 EDETA BD Disodium EDTA 0.1 Extrapone ® Green Glycerin, Water (Aqua), Camellia 0.7 Tea GW Sinensis Leaf Extract Perfume oil PO1, Fragrance 0.5 PO2, PO3, PO4, or PO5 Lara Care A-200 Galactoarabinan 0.5 Neutral Oil Caprylic/Capric Triglyceride 1.0 PCL Liquid 100 Cetearyl Ethylhexoate 0.3 PCL Solid Stearyl Heptanoate, Stearyl Caprylate 3.0 SymOcide ® PS Phenoxyethanol, Decylene Glycol, 1.0 1,2-Hexanediol Water (demineralized) Water (Aqua) ad 100

TABLE-US-00042 TABLE 42 Hair conditioner with UV protection Ingredients INCI Amount Renex PEG 6000 PEG-150 2.5 Hair Conditioner Base Cetyl alcohol, behentrimonium 3.0 chloride, Triticum Vulgare (Wheat) bran extract, linoleic acid PCL-Solid Stearyl heptanoate, stearyl caprylate 0.5 Dow Corning 5200 Laurylmethicone copolyol 0.5 Natrosol 250 HR Hydroxyethylcellulose 0.5 Benzophenone-4 Benzophenone-4 1.0 Neo Heliopan AP Disodiumphenyldibenz-imidazole 1.0 tetrasulphonate Amino methyl propanol Amino methyl propanol 2.0 Dow Corning 949 cationic Amodimethicone, cetrimonium 2.0 emulsion chloride, trideceth-12 Perfume oil PO1, Fragrance 0.8 PO2, PO3, PO4, or PO5 1,2-Hexa nediol 1,2-Hexanediol 0.5 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.2 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Water Water (Aqua) ad 100

TABLE-US-00043 TABLE 43 Hair conditioner, leave on Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.2 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Glyceryl Glyceryl undecylenate 0.05 monoundecylenate Dehyguart A CA Cetrimonium Chloride 0.2 Dehyguart SP Quaternium-52 2.0 Dracorin ® CE Glyceryl Stearate Citrate 1.0 Drago-Calm Water, Glycerin, Avena Sativa 2.0 (Oat) Kernel Extract Farnesol Farnesol Perfume oil PO1, Fragrance 0.5 PO2, PO3, PO4, or PO5 Lara Care A-200 Galactoarabinan 0.1 Polymer JR 400 Polyguaternium-10 0.1 Propylene Glycol Propylene Glycol 0.8 SymMollient ® WS Trideceth-9, PEG-5 Isononanoate, 1.0 Water SymSol ® PF3* Water, Pentylene Glycol, Sodium 1.5 Lauryl Sulfoacetate, Sodium Oleoyl Sarcosinate, Sodium Chloride, Disodium Sulfoacetate, Sodium Oleate, Sodium Sulfate SymTriol ® Caprylyl Glycol, 1,2-Hexanediol, 1.0 Methylbenzyl Alcohol Water (demineralized) Water (Aqua) ad 100

TABLE-US-00044 TABLE 44 Anti-itch hair conditioner, leave on Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate (−)-alpha Bisabolol Bisabolol 0.1 Dehyquart A CA Cetrimonium Chloride 0.5 Dehyquart SP Quaternium-52 4.0 Dracorin ® CE* Glyceryl Stearate Citrate 1.0 Drago-Oat-Active* Water (Aqua), Butylene Glycol, 2.0 Avena Sativa (Oat) Kernel Extract Perfume oil PO1, Fragrance 0.1 PO2, PO3, PO4, or PO5 Lara Care A-200 Galactoarabinan 1.5 Neutral Oil Caprylic/Capric Triglyceride 1.0 PCL Liquid 100* Cetearyl Ethylhexoate 0.3 Polymer JR 400 Polyquaternium-10 0.1 Propylene Glycol Propylene Glycol 0.8 SymGlucan ® Aqua, Glycerin, 1,2-Hexandiol, 5 Caprylyl Glycol, Beta-Glucan SymMollient ® W/S Trideceth-9, PEG-5 Isononanoate, 2.0 Water (Aqua) SymOcide ® PH Phenoxyethanol, 1.2 Hydroxyacetophenone, Caprylyl Glycol, Aqua SymSol ® PF3* Water, Pentylene Glycol, Sodium 1.5 Lauryl Sulfoacetate, Sodium Oleoyl Sarcosinate, Sodium Chloride, Disodium Sulfoacetate, Sodium Oleate, Sodium Sulfate Water, demineralized Water (Aqua) ad 100

TABLE-US-00045 TABLE 45 Sprayable hair conditioner with zinc pyrithrione, leave-on Ingredients INCI Amount Monomuls 60-35 C Hydrogenated Palm Glycerides 1.7 Cetiol OE Dicaprylyl Ether 7.2 Abil 100 Dimethicone 3.6 Dehyquart F 75 Distearoylethyl 4.0 Hydroxyethylmonium, Methosulfate, Cetearyl Alcohol Eumulgin B1 Ceteareth-12 3.5 Cetiol S Diethylhexylcyclohe xane 7.2 D-Panthenol Panthenol 0.1 Glycerol 99, 5 P. Glycerol 1.5 Water Water (Aqua) ad 100 Actipone ® Rosemary Water (Aqua), Propylene, Glycol, Rosmarinus Officinalis, (Rosemary) 0.1 Leaf Extract Frescolat ® ML Cryst. Menthyl Lactate 0.5 Dragosantol100 Bisabolol 0.1 Zinc Omadine Zinc pyrithione 0.1 Perfume oil PO1, Fragrance 0.4 PO2, PO3, PO4, or PO5 2-Phenoxyethyl alcohol Phenoxyethanol 0.4 SymSave H Hydroxyacetophenone 0.3 SymDiol 68 1,2-Hexanediol, Caprylyl glycol 0.3 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.4 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate

TABLE-US-00046 TABLE 46 Hair styling gel Ingredients Amount Water ad 100 PVM/MA Decadiene Crosspolymer 0.6 PVP 3.0 Isocetyl Stearate 4.0 Ethylhexyl Methoxycimamate 0.5 Aminomethyl Propanol 0.4 Perfume oil PO1, PO2, PO3, PO4, or PO5 0.6 SymDiol ® 68T (1,2-Hexanediol, 1,2-Octanediol, Tropolone) 0.4 Phenoxyethanol 0.3 3-Hydroxypropyl caprylate 0.2 3-Hydroxypropyl undecylenate 0.1

TABLE-US-00047 TABLE 47 Deodorant stick Ingredients Amount Sodium stearate 8.0 PPG-3 Myristyl ether 70.0 1,2-propylene glycol 10.0 1,1-dimethyl-3-phenylpropanol 0.2 2-butyloctanoic acid 0.2 Perfume oil PO1, PO2, PO3, PO4, or PO5 0.6 Water ad 100 SymDeo Plus (Jasmol (2-benzlheptanol), 1-Dodecanol (Lauryl Alcohol), 1,2- 0.5 Decanediol (Decylene Glycol), 2-Phenoxyethyl Alcohol (Phenoxyethanol)) 3-Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate 0.15 3-Hydroxypropyl undecylenate 0.1

TABLE-US-00048 TABLE 48 Zirconium suspensoid antiperspirant stick Ingredients INCI Amount PCL Liquid 100 Cetearyl ethylhexanonate ad 100 Silicone Fluid 345 Cyclomethicone 10.0 CRODACOL C90 Cetyl Alcohol 8.0 SYNCROWAX HGLC C18-36 Triglyceride 8.0 CRODAMOL PTC Pentaerythritol 5.0 Tetracaprylate/Caprate SYNCROWAX HRC Tribehenin 4.0 VOLPO N5 Oleth-5 1.0 Titanium Dioxide 1.0 Rezal 36GP Aluminium Tetrachlorohydrex GLY 20.0 Dry Flo C Aluminium Starch Octenyl Succinate 22.5 Preservative Phenoxyethanol 0.8 Perfume oil PO1, Fragrance 0.6 PO2, PO3, PO4, or PO5 3-Hydroxypropyl Hydroxypropyl caprylate 0.15 caprylate Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Glyceryl Glyceryl undecylenate 0.1 monoundecylenate

TABLE-US-00049 TABLE 49 Antiperspirant/deodorant roll-on Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Dragosantol ® 100* Bisabolol 0.1 Ethanol 96% Ethanol 30.0 Farnesol Farnesol 0.5 Perfume oil PO1, Fragrance 1.5 PO2, PO3, PO4, or PO5 Frescolat ®ML cryst. Menthyl Lactate 0.2 lrgasan DP 300 Triclosan 0.3 Natrosol 250 HHR Hydroxyethyl-cellulose 0.3 Solubilizer 611674 PEG-40 Hydrogenated Castor Oil, 2.0 Trideceth-9, Water (Aqua) SymDeo ® B125 2-Methyl 5-Cyclohexylpentanol 0.5 Water (demineralized) Water (Aqua) ad 100 Zirkonal L 450 Aluminium Zirconium Pentachloro- 37.0 hydrate (40% aqueous solution)

TABLE-US-00050 TABLE 50 Deodorant formulation in the form of a roll-on gel Ingredients Amount 1,3-butylene glycol 2.0 PEG-40-hydrogenated castor oil 2.0 Hydroxyethylcellulose 0.5 Perfume oil PO1, PO2, PO3, PO4, or PO5 0.3 1,3-propanediol 0.5 SymGuard CD (3-Phenylpropanol, 0.4 o-cymen-3-ol, Decylene glycol) Ethylhexyl glycerin 0.1 3-Hydroxypropyl caprylate 0.3 Glyceryl monocaprylate 0.15 3-Hydroxypropyl undecylenate 0.1 Water ad 100

TABLE-US-00051 TABLE 51 Clear deo anti-perspirant roll-on Ingredients INCI Amount Methocel E4M Premium Hydroxypropyl Methylcellulose 0.5 Water Water (Aqua) ad 100 Neo-PCL Water Trideceth-9, PEG-5 Ethylhexanoate, 1.0 Soluble N Water (Aqua) Solubilizer PEG-40 Hydrogenated Castor Oil, Trideceth-9, Propylene Glycol, Water 3.0 (Aqua) Deolite Dimethyl Phenylpropanol, Pentylene 0.5 Glycol Locron LW Aluminium Chlorohydrate 25.0 Aloe Vera Gel Aloe Barbadensis Leaf Juice 1.0 Concentrate 10/1 1,2-Propylene Glycol Propylene Glycol 4.0 99 P GC Ethanol 96% Alcohol Denat. 30.0 Perfume oil PO1, Fragrance 1.0 PO2, PO3, PO4, or PO5 3-Hydroxypropyl Hydroxypropyl caprylate 0.3 caprylate 3-Hydroxypropyl Hydroxypropyl undecylenate 0.15 undecylenate

TABLE-US-00052 TABLE 52 Deodorant pump spray with SymClariol Ingredients INCI Amount SymClariol ® Decylene Glycol 0.2 Solubilizer PEG-40 Hydrogenated Castor Oil, Trideceth-9, Propylene Glycol, 4.0 Water (Aqua) Neo-PCL Water Trideceth-9, PEG-5 Ethylhexanoate, 1.5 Soluble N Aqua SymRelief ® Bisabolol, Zingiber Officinale 0.1 (Ginger) Root Extract Water Water (Aqua) ad 100 1,2-Propylene Glycol Propylene Glycol 6.0 Perfume oil PO1, Perfume 0.4 PO2, PO3, PO4, or PO5 SymDiol ® 68 1,2-Hexanediol, Caprylyl Glycol 0.2 3-Hydroxypropyl Hydroxypropyl caprylate 0.2 caprylate 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate

TABLE-US-00053 TABLE 53 Deodorant spray Ingredients Amount PEG-40-hydrogenated castor oil 3.0 Ethylhexylglycerol (Octoxyglycerol) 0.2 Ethanol 40.0 Citrate buffer 0.5 1,2-Hexanediol, 1,2-Octanediol (1:1) 0.3 SymOcide C (o-cymen-5-ol) 0.05 2-Benzylheptan-1-ol (Jasmol) 0.1 Perfume oil PO1, PO2, PO3, PO4, or PO5 0.75 Phenoxyethanol 0.4 3-Hydroxypropyl caprylate 0.2 Glyceryl monoundecylenate 0.1 Water ad 100

TABLE-US-00054 TABLE 54 Sunscreen lotion (o/w, broadband protection) Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.1 Carbopol Ultrez-10 Carbomer 0.2 Dow Corning 246 Fluid Cyclohexasiloxane and 2.0 Cyclopentasiloxane Dragosantol ® 100* Bisabolol 0.3 EDETA BD Disodium EDTA 0.1 Emulsiphos ® Potassium Cetyl Phosphate, 1.5 Hydrogenated Palm Glycerides Perfume oil PO1, PO2, Fragrance 0.4 PO3, PO4, or PO5 Frescolat ®MGA Menthone Glycerol Acetal 0.3 Glycerol 85% Glycerin 4.7 Keltrol RD Xanthan Gum 0.2 Lanette O Cetearyl Alcohol 1.0 Neo Heliopan ® 357 Butyl Methoxy-dibenzoyl-methane 1.0 Neo Heliopan ® AP Disodium Phenyl Dibenzimidazole 10.0 (10% as sodium salt) Tetrasulfonate Neo Heliopan ® AV Ethylhexyl Methoxy-cinnamate 3.0 Neo Heliopan ® Hydro Phenylbenz-imidazole 6.7 (15% as sodium salt) Sulfonic Acid Neo Heliopan ® MBC 4-Methylbenzyl-idene Camphor 1.5 Neo Heliopan ® OS Ethylhexyl Salicylate 5.0 Neutral Oil Caprylic/Capric Triglyceride 2.0 SymMatrix ® Maltodextrin, Rubus Fruticosus 0.3 (Blackberry) Leaf Extract SymOcide ® BHO Hydroxyacetophenone, Benzyl alcohol, Caprylyl glycol, Aqua Tegosoft TN C12-15 Alkyl Benzoate 5.0 Tocopherol Acetate Tocopheryl Acetate 0.5 Triethanolamine, 99% Triethanolamine 0.5 Water (demineralized) Water (Aqua) ad 100

TABLE-US-00055 TABLE 55 Emulsion with UV-A/B-broadband protection Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.1 Glyceryl monocaprylate Glyceryl caprylate 0.1 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.05 Abil 350 Dimethicone 0.3 Butylene Glycol Butylene Glycol 3.0 Carbopol Ultrez-10 Carbomer 0.2 Citric Acid 10% sol. Citric Acid 0.3 Dragosantol ® 100* Bisabolol 0.1 EDETA BD Disodium EDTA 0.1 Emulsiphos ® Potassium Cetyl Phosphate, 1.5 Hydrogenated Palm Glycerides Perfume oil PO1, PO2, Fragrance 0.1 PO3, PO4, or PO5 Frescolat ®X-COOL Menthyl Ethylamido Oxalate 1.0 Glyceryl Stearate Glyceryl Stearate 2.0 Keltrol RD Xanthan Gum 0.2 Lanette 16 Cetyl Alcohol 1.2 Lanette E Sodium Cetearyl Sulfate 0.7 Neo Heliopan ® AP Disodium Phenyl Dibenzimidazole 22.0 (10% as sodium salt) Tetrasulfonate Neo Heliopan ® HMS Homosalate 5.0 Neutral Oil Caprylic/Capric Triglyceride 2.0 PCL Liquid 100 Cetearyl Ethylhexoate 3.0 Sodium Hydroxide (10% Sodium Hydroxide 2.8 sol.) Symdiol ®68 1,2-Hexanediol, Caprylylglycol 0.5 SymMollient ®S Cetearyl Nonanoate 1.5 SymSitive ® 1609 Pentylene Glycol, 4-t- 0.5 Butylcyclohexanol SymWhite ®377 Phenylethyl Resorcinol 0.5 Tocopherol Acetate Tocopheryl Acetate 0.5 Water (demineralized) Water (Aqua) ad 100

TABLE-US-00056 TABLE 56 Sun protection soft cream (w/o), SPF 40 Ingredients INCI Amount Dehymuls PGPH Polyglyceryl-2 5.0 dipolyhydroxystearate Copherol 1250 Tocopheryl acetate 0.5 Permulgin 3220 Ozocerite 0.5 Zinc stearate Zinc stearate 0.5 Tegosoft TN C12-15 Alkyl benzoate 10.0 Neo Heliopan ® E1000 Isoamyl-p-methoxycinnamate 2.0 Neo Heliopan ® 303 Octocrylene 5.0 Neo Heliopan ® MBC 4-Methylbenzylidene camphor 3.0 Zinc oxide, neutral Zinc oxide 5.0 Water, distilled Water (aqua) ad 100 EDETA BD Disodium EDTA 0.1 Glycerol Glycerol 4.0 Magnesium sulfate Magnesium sulfate 0.5 Perfume oil PO1, PO2, Fragrance 0.3 PO3, PO4, or PO5 Symdiol ® 68 1,2-Hexanediol, Caprylylglycol 0.3 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15

TABLE-US-00057 TABLE 57 Sun protection milk (w/o) Ingredients INCI Amount Dehymuls PGPH Polyglyceryl-2 3.0 dipolyhydroxystearate Beeswax 8100 Beeswax 1.0 Monomuls 90-0-18 Glyceryl oleate 1.0 Zinc stea rate Zinc stearate 1.0 Cetiol SN Cetearyl isononanoate 5.0 Cetiol OE Dicaprylyl ether 5.0 Tegosoft TN C12-15 alkyl benzoate 4.0 Vitamin E Tocopherol 0.5 Neo Heliopan ® OS Ethylhexyl salicylate 5.0 Neo Heliopan ® AV Ethylhexyl methoxycinnamate 7.5 Uvinul ® T150 Ethylhexyl triazone 1.5 Water, distilled Water (Aqua) ad 100 Trilon BD Disodium EDTA 0.1 Glycerol Glycerol 5.0 Neo Heliopan ® AP 10% Disodium phenyl dibenzimidazole 15.0 solution, neutralized with tetrasulfonate NaOH Perfume oil PO1, PO2, Fragrance 0.25 PO3, PO4, or PO5 Alpha bisabolol Bisabolol 0.1 SymOcide ® PT Phenoxyethanol, Tropolone 0.25 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.2 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate

TABLE-US-00058 TABLE 58 Sun spray with UV-A/B-broadband protection with low oil content Ingredients INCI Amount 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.05 Ethanol 96% Ethanol 13.0 Perfume oil PO1, PO2, PO3, Fragrance 0.5 PO4, or PO5 Glyceryl Stearate Glyceryl Stearate 4.0 Hydroviton ® PLUS Water, Pentylene Glycol, Glycerin, 1.0 Fructose, Urea, Citric Acid, Sodium Hydroxide, Maltose, Sodium PCA, Sodium Chloride, Sodium Lactate, Trehalose, Allantoin, Sodium hyaluronate, Glucose Isoadipate ® Diisopropyl Adipate 1.0 Neo Heliopan ® AV Ethylhexyl Methoxy-cinnamate 25.0 Neo Heliopan ® MBC 4-Methylbenzyl-idene Camphor 33.3 Propylene Glycol Propylene Glycol 0.8 Tego Betain L7 Cocamidopropyl Betaine 1.0 Water (demineralized) Water (Aqua) ad 100

TABLE-US-00059 TABLE 59 Sunscreen spray o/w, SPE 15-20 Ingredients INCI Amount Dracorin ® GOC Glyceryl Oleate Citrate, 2.0 Caprylic/Capric Triglyceride Corapan ® TQ Diethylhexyl 2,6-Naphthalate 3.0 Neo Heliopan ® HMS Homosalate 7.0 Neo Heliopan ® OS Ethylhexyl Salicylate 5.0 Neo Heliopan ® 357 Butyl Methoxydibenzoylmethane 3.0 Isoadipate Diisopropyl Adipate 6.0 Baysilone ® Oil M10 Dimethicone 1.0 Edeta ® BD Disodium EDTA 0.1 Vitamin E Acetate Tocopheryl Acetate 0.5 Dragosantol ® 100 Bisabolol 0.1 Pemulen ® TR-2 Acrylates/C10-30 Alkyl Acrylate 0.25 Crosspolymer Water Water (Aqua) ad 100 Glycerol 99, 5 P. Glycerol 4.0 Butylene Glycol Butylene Glycol 5.0 Neo Heliopan ® Hydro Phenylbenzimidazole 8.0 (103089), used as 25% aq. Sulfonic Acid solution neutralized with Biotive ® L-Arginine Biotive ® L-Arginine Arginine 0.55 Perfume oil PO1, PO2, PO3, Fragrance 0.4 PO4, or PO5 SymOcide PS Phenoxyethanol, 1,2-Hexanediol, 0.8 Decylene glycol Glyceryl monocaprylate Glyceryl caprylate 0.2 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate

TABLE-US-00060 TABLE 60 After sun gel Ingredients INCI Amount SymSol ® PF-3 Water (Aqua), Pentylene Glycol, 3.0 Sodium Lauryl Sulfoacetate, Sodium Oleoyl Sarcosinate, Sodium Chloride, Disodium Sulfoacetate, Sodium Oleate, Sodium Sulfate Glycerol 99, 5 P. Glycerol 5.0 SymHelios ® 1031 Benzylidene Dimethoxydimethylin 0.1 danone Water Water (Aqua) ad 100 Pemulen ® TR-2 Acrylates/C10-30 Alkyl Acrylate 1.0 Crosspolymer D-Panthenol 75 W Panthenol 0.5 SymFinity ® 1298 Echinacea Purpurea Extract 0.1 Extrapone ® Pearl GW Water (Aqua), Glycerol, Hydrolyzed 1.0 Pearl, Xanthan Gum Sodium Hydroxide 10% Sodium Hydroxide 2.5 solution Ethanol 96% Alcohol Denat. 15.0 Perfume oil PO1, PO2, Fragrance 0.2 PO3, PO4, or PO5 SymOcide ® PS Phenoxyethanol, 1,2-Hexanediol, 0.8 Decyleneglycol 3-Hydroxypropyl Hydroxypropyl caprylate 0.15 caprylate 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate

TABLE-US-00061 TABLE 61 After sun lotion Ingredients Amount Acrylate/C10-30 alkylacrylate crosspolymer 0.4 Cetearylethyl hexanoate 15.0 Bisabolol 0.2 Tocopheryl acetate 1.0 Panthenol 1.0 Alcohol 15.0 Glycerol 3.0 Perfume oil PO1, PO2, PO3, PO4, or PO5 0.30 1,2-Hexanediol 1.0 4-Hydroxyacetophenone 0.3 Pentylene glycol 4.0 Aqua dem. ad 100 Triethanolamine 0.2 3-Hydroxypropyl caprylate 0.2 3-Hydroxypropyl undecylenate 0.1

TABLE-US-00062 TABLE 62 Syndet antimicrobial soap bar Ingredients INCI Amount Zetesap 813 A Disodium Lauryl Sulfosuccinate, ad 100 Sodium Lauryl Sulfate, Corn Starch, Cetearyl Alcohol, Paraffin, Titanium Dioxide Amphotensid GB 2009 Disodium Cocoamphodiacetate 6.0 Allantoin Allantoin 1.0 Perfume oil PO1, PO2, Fragrance 1.0 PO3, PO4, or PO5 SymOcide C o-cymen-5-ol 0.1 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.1 Glyceryl monocaprylate Glyceryl caprylate 0.1 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.05

TABLE-US-00063 TABLE 63 Syndet soap bar Ingredients INCI Amount Fenopon AC-78 Sodium Cocoyl Isethionate 20.0 Natriumlaurylsulfoacetate Sodium Lauryl Sulfoacetate 16.0 Paraffin Paraffin 19.0 Wax, microcrystalline Microcrystalline Wax 1.0 Corn Starch Corn Starch 8.0 Coconut acid Coconut acid 2.0 Lauric acid diethanol amide Lauramide DEA 2.0 Dextrin Dextrin 21.0 Lactic acid, 88% Lactic Acid 1.0 SymGuard CD 3-Phenylpropanol, o-cymen-5-ol, 0.3 Decylene glycol Thymol Thymol 0.05 Water Water ad 100 Perfume oil PO1, PO2, Fragrance 1.0 PO3, PO4, or PO5 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.05

TABLE-US-00064 TABLE 64 Antimicrobial toilet soap bar Ingredients Amount Sodium soap from tallow 60.0 Sodium soap from palm oil 27.0 Glycerol 2.0 Sodium Chloride 0.5 1-Hydroxyethane-1,1-diphosphonic acid, tetrasodium salt 0.3 Alpha-Tocopherol 0.1 Pigment Yellow 1 0.02 Water ad 100 Perfume oil PO1, PO2, PO3, PO4, or PO5 3.0 Farnesol 0.2 3-Hydroxypropyl caprylate 0.1 Glyceryl monocaprylate 0.1 3-Hydroxypropyl undecylenate 0.05 Glyceryl monoundecylenate 0.05

TABLE-US-00065 TABLe 65 Shaving foam Ingredients Amount Dem. Water ad 100 Triethanolamine 4.0 Edenor L2 SM (Stearinic acid, Palmitinic acid) (Cognis) 5.3 Laureth-23 3.0 Stearylalcohol 0.5 SymOcide BHO 1.0 (Hydroxacetophenone, Benzyl alcohol, Caprylyl glycol, Water) 3-Hydroxypropyl caprylate 0.2 Glyceryl monocaprylate 0.1 3-Hydroxypropyl undecylenate 0.1 Glyceryl monoundecylenate 0.05 Sodium lauryl sulfate 3.0 Extrapone Seaweed (water, propylene glycol, 1.0 potassium iodide, Fucus Vesiculosus Extract) Dragosantol (Bisabolol, Farnesol) 0.1 Perfume oil PO1, PO2, PO3, PO4, or PO5 1.0 propane, butane 4, 2 Bar 4.0

TABLE-US-00066 TABLE 66 Sprayable disinfecting gel Ingredients INCI Amount Water Water (Aqua) ad 100 Stabileze QM PVM/Ma Decadiene Crosspolymer 0.25 Sodium Hydroxide 10% Sodium Hydroxide 0.4 solution Coffein pure Caffeine 0.5 Extrapone ® Horse Propylene Glycol, Water (Aqua), 1.0 Chestnut Glucose, Aesculus Hippocastanum (Horse Chestnut) Seed Extract, Lactic Acid Hydrolite ® 5 Pentylene Glycol 3.0 1,3 Butylene Glycol Butylene Glycol 5.0 Biotive ® Esculin Esculin 0.3 Sesquihydrate Ethanol 96% Alcohol Denat. 10.0 Solubilizer PEG-40 Hydrogenated Castor Oil, 0.5 Trideceth-9, Water (Aqua) Perfume oil PO1, PO2, Fragrance 0.2 PO3, PO4, or PO5 Octenidine dihydrochloride 0.1 Preservative Phenoxyethanol 0.7 3-Hydroxypropyl caprylate Hydroxypropyl caprylate 0.15 Glyceryl monocaprylate Glyceryl caprylate 0.15 3-Hydroxypropyl Hydroxypropyl undecylenate 0.05 undecylenate Glyceryl monoundecylenate Glyceryl undecylenate 0.05

TABLE-US-00067 TABLE 67 Solution for wet wipes Ingredients INCI Amount SymSol ® PF-3 Water (Aqua), Pentylene Glycol, 2.0 Sodium Lauryl Sulfoacetate, SodiumOleoyl Sarcosinate, Sodium Chloride, Disodium Sulfoacetate, SodiumOleate, Sodium Sulfate Dragosantol ® 100 Bisabolol 0.1 Glycerol 99, 5 P. Glycerol 5.0 Water Water (Aqua) ad 100 Hydrolite ® 5 Pentylene Glycol 5.0 D-Panthenol 75 W Panthenol 0.8 DragoCalm ® Water (Aqua), Glycerol, Avena Sativa 1.0 (Oat) Kernel Extract Witch Hazel-Distillate Hamamelis Virginiana (Witch Hazel) 1.0 Water, Water (Aqua), Alcohol Allplant Essence ® Org. Pelargonium Graveolens 1.0 Rose Geranium P Flower/Leaf/Stem Water Perfume oil PO1, PO2, Fragrance 0.1 PO3, PO4, or PO5 SymOcide BHO Benzyl alcohol, 0.8 Hydroxyacetophenone, Caprylyl glycol, Water 3-Hydroxypropyl Hydroxypropyl caprylate 0.2 caprylate Glyceryl monocaprylate Glyceryl caprylate 0.2 3-Hydroxypropyl Hydroxypropyl undecylenate 0.1 undecylenate Glyceryl Glyceryl undecylenate 0.1 monoundecylenate

6.) In Vivo Study

[0214] An in vivo study was performed to investigate the potential of 3-hydroxypropyl caprylate for scalp care. The study groups contained 22 persons for the product with active ingredient (3-hydroxypropyl caprylate) and 12 persons for the placebo. The efficacy was assessed based on dermatological evaluation regarding itching as well as on individual subjective perception (questionnaire).

[0215] The active ingredient was provided in a leave-on pump spray (formulation of 0.5 wt.-% of 3-hydroxypropyl caprylate in ethanol/water 70/30 vol/vol; ethanol/water 70/30 vol/vol as placebo). After two weeks of wash out with an active free shampoo, the test product was applied once daily to the scalp (30 spray bursts, every evening, leave-on overnight) for four weeks, while washing with the active free shampoo continued as during the first two weeks of wash out.

[0216] The dermatological evaluation was performed after the two weeks of wash out with active free shampoo by a trained technician on day 1 (before first use of the active-containing leave on-pump spray) and after 28 days of product application (evaluation at day 29). The intensity of itching was determined on a relative scale with the following scores: 0=none; 0.5=very slight; 1=slight; 2=moderate; 3=strong.

[0217] FIG. 5 shows significant reduction of itching in dermatological evaluation in the in vivo study with 22 participants (product with 3-hydroxypropyl caprylate) and 12 participants (placebo) after 4 weeks of application as described above.

[0218] The questionnaire with the following questions was answered by each participant on day 29 of the treatment with the leave-on pump spray (as described above):

[0219] Question 1 (Q1): After test product application: The scalp feels well-cared.

[0220] Question 2 (Q2): After the application, the scalp feeling is pleasant.

[0221] Question 3 (Q3): The product is effective against itching.

[0222] The acceptance was determined on a relative scale with the following scores: −2=fully disagree; −1=rather disagree; 0=neither . . . nor; 1=rather agree; 2=fully agree.

[0223] FIG. 6 shows the acceptance of the product in the in vivo study based on the answers provided by the participants of the study.