MODIFIED PROTEINS AND ASSOCIATED METHODS OF TREATMENT
20220096520 · 2022-03-31
Inventors
- Carlos G. Perez-Garcia (San Diego, CA)
- Padmanabh Chivukula (San Diego, CA)
- Kiyoshi Tachikawa (San Diego, CA)
Cpc classification
C12N9/1018
CHEMISTRY; METALLURGY
A61K31/7105
HUMAN NECESSITIES
C12Y201/03003
CHEMISTRY; METALLURGY
A61K48/005
HUMAN NECESSITIES
International classification
A61K31/7105
HUMAN NECESSITIES
Abstract
The present disclosure provides a modified human protein having improved in vivo stability. The modified human protein has been altered from a wild-type human protein at either at least one ubiquitination site, at the signal peptide portion, or both. The protein of the disclosure can be produced from a codon optimized mRNA suitable for administration to a patient suffering from deficiency of the wild-type protein, wherein upon administration of the mRNA to the patient, the modified protein of the disclosure is expressed in the patient in therapeutically effective amounts.
Claims
1. A modified protein having an amino acid sequence derived from an amino acid sequence of a human wild-type protein, wherein (i) the amino-acid sequence of the human wild-type protein has been modified to remove one or more ubiquitination sites identified as being present in the amino acid sequence of the human wild-type protein but not being present in a homologous non-human animal wild-type protein; (ii) the human wild-type protein has a signal peptide located at a terminal portion, and wherein the amino acid sequence of the signal peptide has been modified by changing an amino acid at the +1 or +2 position or by adding de novo an amino acid at the +1 or +2 position; (iii) the human wild-type protein has a signal peptide located at a terminal portion, and wherein the amino-acid sequence of the human wild-type protein has been modified to remove one or more ubiquitination sites identified as being present in the amino acid sequence of the human wild-type protein but not being present in a homologous non-human animal wild-type protein; or (iv) both (ii) and (iii).
2. The modified protein of claim 1, wherein the homologous non-human animal wild-type protein is a mouse protein.
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5. The modified protein of claim 1, wherein the one or more ubiquitination sites are removed by changing an amino acid at the ubiquitination site.
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7. The modified protein of claim 1, wherein the amino acid residue at the one or more ubiquitination sites is changed to an arginine residue.
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9. The modified protein of claim 1, wherein the signal peptide is located at the N-terminus.
10. The modified protein of claim 1, wherein the signal peptide directs translocation of the wild-type protein (a) for extracellular excretion; (b) to an organelle selected from the group consisting of a mitochondrion, a nucleus, a lysosome, a peroxisome, an endoplasmic reticulum, a Golgi apparatus, and a plasma membrane; or (c) to an interior portion of an intracellular organelle, wherein the intracellular organelle is a mitochondrion.
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15. The modified protein of claim 1, wherein the amino acid sequence of the signal peptide has been modified (a) by changing an amino acid at the +1 or +2 position, wherein the amino acid at the +1 or +2 position is changed to a stabilizing amino acid selected from the group consisting of alanine, glycine, methionine, serine, threonine, valine, and proline; or (b) by adding de novo an amino acid at the +1 or +2 position, wherein the amino acid added at the +1 or +2 position is a stabilizing amino acid selected from the group consisting of alanine, glycine, methionine, serine, threonine, valine, and proline.
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35. The modified protein of claim 1, wherein the human wild-type protein is selected from the group consisting of OTC, ASL, PAH, ABCB4, ABCB11, PAH, AGL, CFTR, MUT, PCCA, PCCB, ASS1, FAH, HMBS, ATP7B, PFIC2, LDLR, G6PC, AGXT, FXN, PAL, BCKDHA, BCKDHB, DBT, UGT1A1, SLC25A13, CD46, CFH, CFI, FIX, FVII, FVIII, C2, C3, C5, GCHD, CBS, MPI, LNL, SERPINGI, UROC1, SMPD1, GLA, GAA, GRHPR, ATP8B1, SERPINCI, PROS1, GBA, ACADVL, HFE, BCKDA, CDG1B, SERPINA1, BMPR2, ENG, ACVR1, SMAD4, BMPR9, HBB, FLCN, HSP1, AP3B1, HPS3, HPS4, HPS5, HPS6, DTNBP1, BLOC1S3, PLDN, AP3D1, BRAF, NF-1, SLC34A2, FBN1, COL1A1, COL1A2, COL1A3, COL5A1, COL5A2, ADAMTS2, PLOD1, TNXB, ABCA3, SP-B, SP-C, GBA, NPC1, NPC2, FOXF1, NKX2-1, SFTPB, SFTPC, ABCA3, CSF2RA, SFTPD, MUC5B, BMPR2, EIF2AK4, CSF2RB, DNAH5, DNAI1, DNAH11, AKR1D1, AMACR, ATP8B1, CYP7A1, FOXC2, GATA2, GHR, HSD3B7, IGFALS, IKBKG, JAGI, KIF11, NOTCHI, NOTCH2, NR1H4, SOX18, TJP2, P53, P73, P63, VIPAS39, VPS33B, EPO, ARGI, CPS1, NAGS, NOS, KRAS, OX40L, IL12, VEGF-A, MMA, TTR, PCSK9, AT, and ALAS1.
36. A polynucleotide comprising a sequence encoding the modified protein of claim 1.
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40. The polynucleotide of claim 36, wherein the polynucleotide is an mRNA comprising an open reading frame encoding the modified protein, wherein the open reading frame (a) is a codon-optimized open reading frame; or (b) is optimized to have a theoretical minimum of uridines possible.
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43. The polynucleotide of claim 36, wherein the polynucleotide is an mRNA comprising one or more chemically-modified nucleotides selected from the group consisting of 5-hydroxycytidine, 5-methylcytidine, 5-hydroxymethylcytidine, 5-carboxycytidine, 5-formylcytidine, 5-methoxycytidine, 5-propynylcytidine, 2-thiocytidine, 5-hydroxyuridine, 5-methyluridine, 5,6-dihydro-5-methyluridine, 2′-O-methyluridine, 2′-O-methyl-5-methyluridine, 2′-fluoro-2′-deoxyuridine, 2′-amino-2′-deoxyuridine, 2′-azido-2′-deoxyuridine, 4-thiouridine, 5-hydroxymethyluridine, 5-carboxyuridine, 5-carboxymethylesteruridine, 5-formyluridine, 5-methoxyuridine, 5-propynyluridine, 5-bromouridine, 5-iodouridine, 5-fluorouridine, pseudouridine, 2′-O-methyl-pseudouridine, N.sup.1-hydroxypseudouridine, N.sup.1-methylpseudouridine, 2′-O-methyl-N.sup.1-methylpseudouridine, N.sup.1-ethylpseudouridine, N.sup.1-hydroxymethylpseudouridine, Arauridine, N.sup.6-methyladenosine, 2-aminoadenosine, 3-methyladenosine, 7-deazaadenosine, 8-oxoadenosine, inosine, thienoguanosine, 7-deazaguanosine, 8-oxoguanosine, and 6-O-methylguanine.
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56. A composition comprising one or more polynucleotides of claim 36 and a pharmaceutically acceptable carrier, wherein the one or more polynucleotides are mRNAs, and wherein the carrier comprises a transfection reagent, a nanoparticle, or a liposome.
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68. A method of modifying a protein of interest, wherein the protein of interest is a human wild-type protein, the method comprising the steps of: i) identifying ubiquitination sites in the amino acid sequence of the human wild-type protein which are not present in the amino acid sequence of a homologous non-human animal wild-type protein; and ii) removing at least one of the ubiquitination sites identified in step (i) from the amino acid sequence of the human wild-type protein to provide a modified protein of interest.
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71. The method of claim 68, wherein the homologous non-human animal wild-type protein is a murine protein.
72. The method of claim 68, wherein the removing of step (ii) comprises (a) replacing an amino acid residue at the at least one of the ubiquitination sites; or (b) replacing a lysine residue at the at least one of the ubiquitination sites with an arginine residue.
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74. The method of claim 68, wherein the human wild-type protein comprises a signal peptide at a terminal portion, and the method further comprises modifying the amino acid sequence of the signal peptide by changing an amino acid at the +1 or +2 position or by adding an amino acid at the +1 or +2 position.
75. The method of claim 74, wherein the signal peptide is located at the N-terminus.
76. The method of claim 74, wherein the signal peptide directs translocation of the human wild-type protein (a) for extracellular excretion; (b) to an organelle selected from the group consisting of a mitochondrion, a nucleus, a lysosome, a peroxisome, an endoplasmic reticulum, a Golgi apparatus, and a plasma membrane; or (c) to an interior portion of an organelle, wherein the organelle is a mitochondrion.
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81. The method of claim 74, wherein modifying the amino acid sequence of the signal peptide comprises (a) changing an amino acid at the +1 or +2 position, wherein the amino acid at the +1 or +2 position is changed to a stabilizing amino acid selected from the group consisting of alanine, glycine, methionine, serine, threonine, valine, and proline; or (b) adding an amino acid at the +1 or +2 position, wherein the amino acid added at the +1 or +2 position is a stabilizing amino acid selected from the group consisting of alanine, glycine, methionine, serine, threonine, valine, and proline.
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85. The method of claim 74, wherein the human wild-type protein is selected from the group consisting of OTC, ASL, PAH, ABCB4, ABCB11, PAH, AGL, CFTR, MUT, PCCA, PCCB, ASS1, FAH, HMBS, ATP7B, PFIC2, LDLR, G6PC, AGXT, FXN, PAL, BCKDHA, BCKDHB, DBT, UGT1A1, SLC25A13, CD46, CFH, CFI, FIX, FVII, FVIII, C2, C3, C5, GCHD, CBS, MPI, LNL, SERPINGI, UROC1, SMPD1, GLA, GAA, GRHPR, ATP8B1, SERPINCI, PROS1, GBA, ACADVL, HFE, BCKDA, CDG1B, SERPINA1, BMPR2, ENG, ACVR1, SMAD4, BMPR9, HBB, FLCN, HSP1, AP3B1, HPS3, HPS4, HPS5, HPS6, DTNBP1, BLOC1S3, PLDN, AP3D1, BRAF, NF-1, SLC34A2, FBN1, COL1A1, COL1A2, COL1A3, COL5A1, COL5A2, ADAMTS2, PLOD1, TNXB, ABCA3, SP-B, SP-C, GBA, NPC1, NPC2, FOXF1, NKX2-1, SFTPB, SFTPC, ABCA3, CSF2RA, SFTPD, MUC5B, BMPR2, EIF2AK4, CSF2RB, DNAH5, DNAI1, DNAH11, AKR1D1, AMACR, ATP8B1, CYP7A1, FOXC2, GATA2, GHR, HSD3B7, IGFALS, IKBKG, JAG1, KIF11, NOTCH1, NOTCH2, NR1H4, SOX18, TJP2, P53, P73, P63, VIPAS39, VPS33B, EPO, ARGI, CPS1, NAGS, NOS, KRAS, OX40L, IL12, VEGF-A, MMA, TTR, PCSK9, AT, and ALAS1.
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Description
BRIEF DESCRIPTION OF THE DRAWINGS
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DETAILED DESCRIPTION
Definitions
[0026] The term “mitochondrial protein” is a protein identified as being localized within the mitochondria.
[0027] As used herein, the term “nuclear expressed mitochondrial protein” is a protein identified as being transcribed from nuclear DNA. A database with a listing of these proteins is the MitoCarta as described in the following: Sarah E. Calvo, Karl R. Clauser, Vamsi K. Mootha; MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins, Nucleic Acids Research, Volume 44, Issue D1, 4 Jan. 2016, Pages D1251-D1257.
[0028] The term “ornithine transcarbamylase” as used interchangeably herein with “OTC” or “hOTC”, or “OTC HUMAN” generally refers to the human protein associated with UniPRotKB-P00480. The amino acid sequence for the wild type human OTC protein is represented herein by SEQ ID NO: 3.
[0029] As used herein, the term “therapeutic protein” means a protein that can be used to replace a protein in a patient deficient of such protein or wherein such protein does not possess the activity needed for normal function in a patient.
[0030] The term “nucleic acid,” in its broadest sense, includes any compound and/or substance that comprise a polymer of nucleotides. These polymers are often referred to as polynucleotides. Exemplary nucleic acids or polynucleotides described herein include, but are not limited to, ribonucleic acids (RNAs), deoxyribonucleic acids (DNAs), threose nucleic acids (TNAs), glycol nucleic acids (GNAs), peptide nucleic acids (PNAs), locked nucleic acids (LNAs, including LNA having a β-D-ribo configuration, α-LNA having an α-L-ribo configuration (a diastereomer of LNA), 2′-amino-LNA having a 2′-amino functionalization, and 2′-amino-α-LNA having a 2′-amino functionalization) or hybrids thereof.
[0031] As used herein, the term “polynucleotide” is generally used to refer to a nucleic acid (e.g., DNA or RNA). When RNA, such as mRNA, is specifically being referred to, the term polyribonucleotide may be used. The terms polynucleotide, polyribonucleotide, nucleic acid, ribonucleic acid, DNA, RNA, mRNA, and the like include such molecules that may be comprised of standard or unmodified residues; nonstandard or modified residues (e.g., analogs); and mixtures of standard and nonstandard (e.g., analogs) residues. In certain embodiments a polynucleotide or a polyribonucleotide is a modified polynucleotide or a polyribonucleotide. In the context of the present disclosure, for each RNA (polyribonucleotide) sequence listed herein, the corresponding DNA (polydeoxyribonucleotide or polynucleotide) sequence is contemplated and vice versa. “Polynucleotide” may be used interchangeably with the “oligomer”. Polynucleotide sequences shown herein are from left to right, 5′ to 3′, unless stated otherwise.
[0032] As used herein, the term “messenger RNA” (mRNA) refers to any polynucleotide which encodes a protein or polypeptide of interest and which is capable of being translated to produce the encoded protein or polypeptide of interest in vitro, in vivo, in situ or ex vivo.
[0033] As used herein, the term “translation” is the process in which ribosomes create polypeptides. In translation, messenger RNA (mRNA) is decoded by transfer RNAS (tRNAs) in a ribosome complex to produce a specific amino acid chain, or polypeptide. The coding region of a polynucleotide sequence (DNA or RNA), also known as the coding sequence or CDS, is capable of being converted to a protein or a fragment thereof by the process of translation.
[0034] As used herein, the term “codon-optimized” means a natural (or purposefully designed variant of a natural) coding sequence which has been redesigned by choosing different codons without altering the encoded protein amino acid sequence. Codon optimized sequence can increase the protein expression levels (Gustafsson et al., Codon bias and heterologous protein expression. 2004, Trends Biotechnol 22: 346-53) of the encoded proteins amongst providing other advantages. Variables such as high codon adaptation index (CAI), LowU method, mRNA secondary structures, cis-regulatory sequences, GC content and many other similar variables have been shown to somewhat correlate with protein expression levels (Villalobos et al., Gene Designer: a synthetic biology tool for constructing artificial DNA segments. 2006, BMC Bioinformatics 7:285). High CAI (codon adaptation index) method picks a most frequently used synonymous codon for an entire protein coding sequence. The most frequently used codon for each amino acid is deduced from 74,218 protein-coding genes from a human genome. The Low U method targets only U-containing codons that can be replaced with a synonymous codon with fewer U moieties. If there are a few choices for the replacement, the more frequently used codon will be selected. The remaining codons in the sequence are not changed by the Low U method. This method may be used in conjunction with the disclosed mRNAs to design coding sequences that are to be synthesized with, for example, 5-methoxyuridine or N1-methylpseudouridine.
[0035] As used herein, “modified” refers to a change in the state or structure of a molecule disclosed herein. The molecule may be changed in many ways including chemically, structurally or functionally. Preferably a polynucleotide or polypeptide of the disclosure are modified as compared to the native form of the polynucleotide or polypeptide or as compared to a reference polypeptide sequence or polynucleotide sequence. For example, mRNA disclosed herein may be modified by codon optimization, or by the insertion of non-natural nucleosides or nucleotides. Polypeptides may be modified, for example, by site specific amino acid deletions or substitutions to alter the properties of the polypeptide.
[0036] As used herein, the term “homology” refers to the overall relatedness between polymeric molecules, e.g. between nucleic acid molecules (e.g. DNA molecules and/or RNA molecules) and/or between polypeptide molecules. In some embodiments, polymeric molecules are considered to be “homologous” to one another if their sequences are at least 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 99% identical or similar. The term “homologous” necessarily refers to a comparison between at least two sequences (polynucleotide or polypeptide sequences). In accordance with the present disclosure, two polynucleotide sequences are considered to be homologous if the polypeptides they encode are at least about 50%, 60%, 70%, 80%, 90%, 95%, or even 99% for at least one stretch of at least about 20 amino acids. In some embodiments, homologous polynucleotide sequences are characterized by the ability to encode a stretch of at least 4-5 uniquely specified amino acids. For polynucleotide sequences less than 60 nucleotides in length, homology is determined by the ability to encode a stretch of at least 4-5 uniquely specified amino acids. In accordance with the present disclosure, two protein sequences are considered to be homologous if the proteins are at least about 50%, 60%, 70%, 80%, or 90% identical for at least one stretch of at least about 20 amino acids.
[0037] As used herein, the term “identity” refers to the overall relatedness between polymeric molecules, e.g., between oligonucleotide molecules (e.g. DNA molecules and/or RNA molecules) and/or between polypeptide molecules. Calculation of the percent identity of two polynucleotide sequences, for example, can be performed by aligning the two sequences for optimal comparison purposes. In certain embodiments, the length of a sequence aligned for comparison purposes is at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 95%, or 100% of the length of the reference sequence. The nucleotides at corresponding nucleotide positions are then compared. When a position in the first sequence is occupied by the same nucleotide as the corresponding position in the second sequence, then the molecules are identical at that position. The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, which needs to be introduced for optimal alignment of the two sequences. The comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm. Methods commonly employed to determine percent identity between sequences include, but are not limited to those disclosed in Carillo, H., and Lipman, D., SIAM J Applied Math., 48:1073 (1988); incorporated herein by reference. Techniques for determining identity are codified in publicly available computer programs. Exemplary computer software to determine homology between two sequences include, but are not limited to, GCG program package, Devereux, J., et al., Nucleic Acids Research, 12(1), 387 (1984), BLASTP, BLASTN, and FASTA Altschul, S. F. et al., J. Molec. Biol., 215, 403 (1990).
[0038] An “effective amount” of the mRNA sequence encoding an open reading frame (ORF) protein or a corresponding composition thereof is generally that amount of mRNA that provides efficient ORF protein production in a cell. Preferably protein production using an mRNA composition described herein is more efficient than a composition containing a corresponding wild type mRNA encoding an ORF protein. Increased efficiency may be demonstrated by increased cell transfection (i.e., the percentage of cells transfected with the nucleic acid), increased protein translation from the nucleic acid, decreased nucleic acid degradation (as demonstrated, e.g., by increased duration of protein translation from a modified nucleic acid), or reduced innate immune response of the host cell. When referring to an ORF protein described herein, an effective amount is that amount of ORF protein that overcomes an ORF protein deficiency in a cell.
[0039] As used herein, the term “in vitro” refers to events that occur in an artificial environment, e.g., in a test tube or reaction vessel, in cell culture, in a Petri dish, etc., rather than within an organism (e.g., animal, plant, or microbe).
[0040] As used herein, the term “in vivo” refers to events that occur within an organism (e.g., animal, plant, or microbe or cell or tissue thereof).
[0041] As used herein, the term “isolated” refers to a substance or entity that has been separated from at least some of the components with which it was associated (whether in nature or in an experimental setting). Isolated substances may have varying levels of purity in reference to the substances from which they have been associated. Isolated substances and/or entities may be separated from at least about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, or more of the other components with which they were initially associated. In some embodiments, isolated agents are more than about 80%, about 85%, about 90%, about 91%, about 92%, about 93%, about 94%, about 95%, about 96%, about 97%, about 98%, about 99%, or more than about 99% pure. As used herein, a substance is “pure” if it is substantially free of other components. Substantially isolated: By “substantially isolated” is meant that the compound is substantially separated from the environment in which it was formed or detected. Partial separation can include, for example, a composition enriched in the compound described herein. Substantial separation can include compositions containing at least about 50%, at least about 60%, at least about 70%, at least about 80%, at least about 90%, at least about 95%, at least about 97%, or at least about 99% by weight of the compound described herein, or salt thereof. Methods for isolating compounds and their salts are routine in the art.
[0042] As used herein, the term “subject” or “patient” refers to any organism to which a composition in accordance with the present disclosure may be administered, e.g., for experimental, diagnostic, prophylactic, and/or therapeutic purposes. Typical subjects include animals (e.g., mammals such as mice, rats, rabbits, non-human primates, and humans) and/or plants. Preferably “patient” refers to a human subject who may seek or be in need of treatment, requires treatment, is receiving treatment, will receive treatment, or a subject who is under care by a trained professional for a particular disease or condition.
[0043] The phrase “pharmaceutically acceptable” is employed herein to refer to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit/risk ratio.
[0044] As used herein, the term “preventing” refers to partially or completely delaying onset of an infection, disease, disorder and/or condition; partially or completely delaying onset of one or more symptoms, features, or clinical manifestations of a particular infection, disease, disorder, and/or condition; partially or completely delaying onset of one or more symptoms, features, or manifestations of a particular infection, disease, disorder, and/or condition; partially or completely delaying progression from an infection, a particular disease, disorder and/or condition; and/or decreasing the risk of developing pathology associated with the infection, the disease, disorder, and/or condition.
[0045] As used herein, the term “substantially” refers to the qualitative condition of exhibiting total or near-total extent or degree of a characteristic or property of interest. One of ordinary skill in the biological arts will understand that biological and chemical phenomena rarely, if ever, go to completion and/or proceed to completeness or achieve or avoid an absolute result. The term “substantially” is therefore used herein to capture the potential lack of completeness inherent in many biological and chemical phenomena.
[0046] As used herein, the term “therapeutically effective amount” means an amount of an agent to be delivered (e.g., nucleic acid, protein or peptide, drug, therapeutic agent, diagnostic agent, prophylactic agent, etc.) that is sufficient, when administered to a subject suffering from or susceptible to an infection, disease, disorder, and/or condition, to treat, improve symptoms of, diagnose, prevent, and/or delay the onset of the infection, disease, disorder, and/or condition.
[0047] As used herein, a “total daily dose” is an amount given or prescribed in a 24 hr period. It may be administered as a single unit dose.
[0048] As used herein, the term “treating” refers to partially or completely alleviating, ameliorating, improving, relieving, delaying onset of, inhibiting progression of, reducing severity of, and/or reducing incidence of one or more symptoms or features of a protein deficiency. Treatment may be administered to a subject who does not exhibit signs of said protein deficiency and/or to a subject who exhibits only early signs of the protein deficiency for the purpose of decreasing the risk of developing pathology associated with the disease, disorder, and/or condition.
[0049] As used herein, the terms “transfect” or “transfection” mean the intracellular introduction of a nucleic acid into a cell, or preferably into a target cell. The introduced nucleic acid may be stably or transiently maintained in the target cell. The term “transfection efficiency” refers to the relative amount of nucleic acid up-taken by the target cell which is subject to transfection. In practice, transfection efficiency is estimated by the amount of a reporter nucleic acid product expressed by the target cells following transfection. Preferred are compositions with high transfection efficacies and in particular those compositions that minimize adverse effects which are mediated by transfection of non-target cells and tissues.
[0050] As used herein, the term “target cell” refers to a cell or tissue to which a composition of the disclosure is to be directed or targeted. In some embodiments, the target cells are deficient in a protein or enzyme of interest. For example, where it is desired to deliver a nucleic acid to a hepatocyte, the hepatocyte represents the target cell. In some embodiments, the nucleic acids and compositions of the present disclosure transfect the target cells on a discriminatory basis (i.e., do not transfect non-target cells). The compositions and methods of the present disclosure may be prepared to preferentially target a variety of target cells, which include, but are not limited to, hepatocytes, epithelial cells, hematopoietic cells, epithelial cells, endothelial cells, lung cells, bone cells, stem cells, mesenchymal cells, neural cells (e.g., meninges, astrocytes, motor neurons, cells of the dorsal root ganglia and anterior hom motor neurons), photoreceptor cells (e.g., rods and cones), retinal pigmented epithelial cells, secretory cells, cardiac cells, adipocytes, vascular smooth muscle cells, cardiomyocytes, skeletal muscle cells, beta cells, pituitary cells, synovial lining cells, ovarian cells, testicular cells, fibroblasts, B cells, T cells, reticulocytes, leukocytes, granulocytes and tumor cells.
[0051] Following transfection of one or more target cells by the compositions and nucleic acids described herein, expression of the protein encoded by such nucleic acid may be preferably stimulated and the capability of such target cells to express the protein of interest is enhanced. For example, transfection of a target cell with a mRNA will allow expression of the modified protein product following translation of the nucleic acid. The nucleic acids of the compositions and/or methods provided herein preferably encode a product (e.g., a protein, enzyme, polypeptide, peptide, functional RNA, and/or antisense molecule), and preferably encode a product whose in vivo production is desired.
[0052] As used herein “an OTC protein enzymatic activity” refers to enzyme activity that catalyzes the reaction between carbamoyl phosphate and ornithine to form citrulline as part of the urea cycle in mammals.
[0053] As used herein, the term “about” or “approximately” as applied to one or more values of interest, refers to a value that is similar to a stated reference value. In certain embodiments, the term “approximately” or “about” refers to a range of values that fall within 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, or less in either direction (greater than or less than) of the stated reference value unless otherwise stated or otherwise evident from the context (except where such number would exceed 100% of a possible value).
Polynucleotide Sequences
[0054] The present disclosure provides improved methods and compositions for the treatment of diseases related to protein deficiency, for example ornithine transcarbamylase (OTC) deficiency using, for example, mRNA therapy to express a modified protein of the present disclosure. The present disclosure provides methods of treating a protein deficiency, comprising administering to a subject in need of treatment a composition comprising an mRNA sequence described herein encoding a stabilized modified human protein or active fragments of such stabilized modified human protein at an effective dose and an administration interval such that at least one symptom or feature of the protein deficiency is reduced in intensity, severity, or frequency or has delayed onset. The present disclosure also provides modified proteins encoded by the mRNA sequences wherein the modified proteins have improved properties such as enhanced stability and resistance to protein degradation and increased half-life as compared to wild type human proteins.
[0055] Preferably, the administration of an mRNA composition described herein results in an increased therapeutic protein expression or activity of the subject as compared to a control level. Preferably, the control level is a baseline serum therapeutic protein expression or activity level in the subject prior to the treatment and/or the control level is indicative of the average serum protein expression or activity level in patients without treatment.
[0056] Preferably, the proteins encoded by the mRNA described herein are produced from a heterologous mRNA construct comprising an open reading frame (ORF) also referred to herein as a “coding sequence” (CDS) encoding for a therapeutic protein. Preferably, the coding sequence is codon-optimized. Preferably, coding sequence is optimized to have a theoretical minimum of uridines possible to encode for a therapeutic protein. Preferably, the mRNA constructs described herein comprise one or more of the following features: a 5′ cap; a 5′UTR, a 5′UTR enhancer sequence, a Kozak sequence or a partial Kozak sequence, a 3′UTR, an open reading frame encoding a therapeutic protein protein and a poly A tail. Preferably, the mRNA constructs described herein can provide high-efficiency expression of a modified protein. The expression can be in vitro, ex vivo, or in vivo.
[0057] An exemplary human modified protein encoded by an mRNA described herein comprises a modified human OTC protein of SEQ ID NO: 4 shown in Table 1. SEQ ID NO: 4 has been modified from wild-type OTC of SEQ ID NO: 3 (Table 1) to remove one or more predicted ubiquitination sites resulting in a protein that is less susceptible to ubiquitination and degradation by ubiquitin ligases. The removal of predicted ubiquitination sites preferably comprises replacing N-terminus residues that have been found to support ubiquitination such as asparagine, arginine, leucine, lysine or phenylalanine with residues that have been found to be stabilizing against ubiquitination such as alanine, glycine, methionine, serine, threonine, valine and proline. Stabilization of the modified OTC protein of SEQ ID NO: 4 in this manner is particularly advantageous for preserving the stability of the modified OTC protein during its transport from the cytosol to the mitochondria wherein it exerts its enzymatic activity.
[0058] Preferably, a modified protein encoded by an mRNA described herein comprises a protein sequence that is at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, or 100% identical to a corresponding human wild type protein, while retaining protein's biological and chemical activity such as catalytic activity.
TABLE-US-00001 TABLE 1 Selected OTC Nucleotide and Peptide Sequences mRNA coding AUGCUGUUUAAUCUGAGGAUCCUGUUAAACAAUGCAGCUUUUAGAAA sequence for wild UGGUCACAACUUCAUGGUUCGAAAUUUUCGGUGUGGACAACCACUAC type human OTC AAAAUAAAGUGCAGCUGAAGGGCCGUGACCUUCUCACUCUAAAAAAC UUUACCGGAGAAGAAAUUAAAUAUAUGCUAUGGCUAUCAGCAGAUCU GAAAUUUAGGAUAAAACAGAAAGGAGAGUAUUUGCCUUUAUUGCAAG GGAAGUCCUUAGGCAUGAUUUUUGAGAAAAGAAGUACUCGAACAAGA UUGUCUACAGAAACAGGCUUUGCACUUCUGGGAGGACAUCCUUGUUU UCUUACCACACAAGAUAUUCAUUUGGGUGUGAAUGAAAGUCUCACGG ACACGGCCCGUGUAUUGUCUAGCAUGGCAGAUGCAGUAUUGGCUCGA GUGUAUAAACAAUCAGAUUUGGACACCCUGGCUAAAGAAGCAUCCAU CCCAAUUAUCAAUGGGCUGUCAGAUUUGUACCAUCCUAUCCAGAUCCU GGCUGAUUACCUCACGCUCCAGGAACACUAUAGCUCUCUGAAAGGUCU UACCCUCAGCUGGAUCGGGGAUGGGAACAAUAUCCUGCACUCCAUCAU GAUGAGCGCAGCGAAAUUCGGAAUGCACCUUCAGGCAGCUACUCCAAA GGGUUAUGAGCCGGAUGCUAGUGUAACCAAGUUGGCAGAGCAGUAUG CCAAAGAGAAUGGUACCAAGCUGUUGCUGACAAAUGAUCCAUUGGAA GCAGCGCAUGGAGGCAAUGUAUUAAUUACAGACACUUGGAUAAGCAU GGGACAAGAAGAGGAGAAGAAAAAGCGGCUCCAGGCUUUCCAAGGUU ACCAGGUUACAAUGAAGACUGCUAAAGUUGCUGCCUCUGACUGGACA UUUUUACACUGCUUGCCCAGAAAGCCAGAAGAAGUGGAUGAUGAAGU CUUUUAUUCUCCUCGAUCACUAGUGUUCCCAGAGGCAGAAAACAGAA AGUGGACAAUCAUGGCUGUCAUGGUGUCCCUGCUGACAGAUUACUCA CCUCAGCUCCAGAAGCCUAAAUUUUGA (SEQ ID NO: 1) DNA coding ATGCTGTTTAATCTGAGGATCCTGTTAAACAATGCAGCTTTTAGAAATGG sequence for wild TCACAACTTCATGGTTCGAAATTTTCGGTGTGGACAACCACTACAAAATA type human OTC AAGTGCAGCTGAAGGGCCGTGACCTTCTCACTCTAAAAAACTTTACCGG AGAAGAAATTAAATATATGCTATGGCTATCAGCAGATCTGAAATTTAGG ATAAAACAGAAAGGAGAGTATTTGCCTTTATTGCAAGGGAAGTCCTTAG GCATGATTTTTGAGAAAAGAAGTACTCGAACAAGATTGTCTACAGAAAC AGGCTTTGCACTTCTGGGAGGACATCCTTGTTTTCTTACCACACAAGATA TTCATTTGGGTGTGAATGAAAGTCTCACGGACACGGCCCGTGTATTGTCT AGCATGGCAGATGCAGTATTGGCTCGAGTGTATAAACAATCAGATTTGG ACACCCTGGCTAAAGAAGCATCCATCCCAATTATCAATGGGCTGTCAGA TTTGTACCATCCTATCCAGATCCTGGCTGATTACCTCACGCTCCAGGAAC ACTATAGCTCTCTGAAAGGTCTTACCCTCAGCTGGATCGGGGATGGGAA CAATATCCTGCACTCCATCATGATGAGCGCAGCGAAATTCGGAATGCAC CTTCAGGCAGCTACTCCAAAGGGTTATGAGCCGGATGCTAGTGTAACCA AGTTGGCAGAGCAGTATGCCAAAGAGAATGGTACCAAGCTGTTGCTGAC AAATGATCCATTGGAAGCAGCGCATGGAGGCAATGTATTAATTACAGAC ACTTGGATAAGCATGGGACAAGAAGAGGAGAAGAAAAAGCGGCTCCAG GCTTTCCAAGGTTACCAGGTTACAATGAAGACTGCTAAAGTTGCTGCCTC TGACTGGACATTTTTACACTGCTTGCCCAGAAAGCCAGAAGAAGTGGAT GATGAAGTCTTTTATTCTCCTCGATCACTAGTGTTCCCAGAGGCAGAAAA CAGAAAGTGGACAATCATGGCTGTCATGGTGTCCCTGCTGACAGATTAC TCACCTCAGCTCCAGAAGCCTAAATTTTGA (SEQ ID NO: 2) Human wild type MLFNLRILLNNAAFRNGHNFMVRNFRCGQPLQNKVQLKGRDLLTLKNFTG OTC amino acid EEIKYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFA sequence LLGGHPCFLTTQDIHLGVNESLTDTARVLSSMADAVLARVYKQSDLDTLAK (The signal peptide EASIPIFGLSDLYHPIQILADYLTLQEHYSSLKGLTLSWIGDGNNILHSIMMS for mitochondrial AAKFGMHLQAATPKGYEPDASVTKLAEQYAKENGTKLLLTNDPLEAAHGG import is NVLITDTWISMGQEEEKKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRK underlined*) PEEVDDEVFYSPRSLVFPEAENRKWTIMAVMVSLLTDYSPQLQKPKF (SEQ ID NO: 3) Modified OTC amino MLVFNLRILLNNAAFRNGHNFMVRNFRCGQPLQNRVQLKGRDLLTLKNFTGE acid sequence EIRYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFALLGGH (The signal peptide PCFLTTQDIHLGVNESLTDTARVLSSMADAVLARVYKQSDLDTLAKEASIPIINGLS for mitochondrial DLYHPIQILADYLTLQEHYSSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQAAT import is PKGYEPDASVTKLAEQYAKENGTKLLLTNDPLEAAHGGNVLITDTWISMGQEEEK underlined*) KKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAEN RKWTIMAVMVSLLTDYSPQLQKPKF (SEQ ID NO: 4) *The OTC protein comprises a signal peptide which is translated and which is responsible for translocation to the mitochondria. This signal peptide is represented by the first 32 amino acids as underlined in SEQ ID NO: 3 and SEQ ID NO: 4. The signal sequence of SEQ ID NO: 4 has also been modified as compared to SEQ ID NO: 3. An amino acid, valine is inserted at position 3 of SEQ ID NO: 4. This modification provides better mitochondrial localization of the modified OTC of SEQ ID NO: 4 as compared to wild type human OTC of SEQ ID NO: 3.
[0059] Preferably, the open reading frame (ORF) or coding sequence (CDS) of an mRNA sequence described herein encodes an amino acid sequence that is substantially identical to that of the corresponding human wild-type protein.
[0060] Preferably an mRNA described herein further comprises a sequence immediately downstream (i.e., in the 3′ direction from) of the CDS that creates a triple stop codon. The triple stop codon may be incorporated to enhance the efficiency of translation. In some embodiments, the translatable oligomer may comprise the sequence AUAAGUGAA (SEQ ID NO: 25) immediately downstream of a CDS of an mRNA sequence described herein.
[0061] Preferably, an mRNA described herein further comprises a 5′ untranslated region (UTR) sequence. As is understood in the art, the 5′ and/or 3′ UTR may affect an mRNA's stability or efficiency of translation. The 5′ UTR may be derived from an mRNA molecule known in the art to be relatively stable (e.g., histone, tubulin, globin, glyceraldehyde 1-phosphate dehydrogenase (GAPDH), actin, or citric acid cycle enzymes) to increase the stability of the translatable oligomer. In other embodiments, a 5′ UTR sequence may include a partial sequence of a cytomegalovirus (CMV) immediate-early 1 (IE1) gene.
[0062] Preferably, the 5′ UTR comprises a sequence selected from the 5′ UTRs of human IL-6, alanine aminotransferase 1, human apolipoprotein E, human fibrinogen alpha chain, human transthyretin, human haptoglobin, human alpha-1-antichymotrypsin, human antithrombin, human alpha-1-antitrypsin, human albumin, human beta globin, human complement C3, human complement C5, SynK (thylakoid potassium channel protein derived from the cyanobacteria, Synechocystis sp.), mouse beta globin, mouse albumin, and a tobacco etch virus, or fragments of any of the foregoing. Preferably, the 5′ UTR is derived from a tobacco etch virus (TEV). Preferably, an mRNA described herein comprises a 5′ UTR sequence that is derived from a gene expressed by Arabidopsis thaliana. Preferably, the 5′ UTR sequence of a gene expressed by Arabidopsis thaliana is AT1G58420. Preferred 5′ UTR sequences comprise SEQ ID NOS: 5-10, 125-127 and 227-247: as shown in Table 2.
TABLE-US-00002 TABLE 2 5′ UTR sequences Name Sequence Seq ID No.: EV UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCA SEQ ID NO: 5 UUCUACUUCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCA AAAGCAAUUUUCUGAAAAUUUUCACCAUUUACGAACGAUAG AT1G58420 AUUAUUACAUCAAAACAAAAAGCCGCCA SEQ ID NO: 6 ARC5-2 CUUAAGGGGGCGCUGCCUACGGAGGUGGCAGCCAUCUCCUUCU SEQ ID NO: 7 CGGCAUCAAGCUUACCAUGGUGCCCCAGGCCCUGCUCUUGGUCC CGCUGCUGGUGUUCCCCCUCUGCUUCGGCAAGUUCCCCAUCUAC ACCAUCCCCGACAAGCUGGGGCCGUGGAGCCCCAUCGACAUCCA CCACCUGUCCUGCCCCAACAACCUCGUGGUCGAGGACGAGGGCU GCACCAACCUGAGCGGGUUCUCCUAC HCV UGAGUGUCGU ACAGCCUCCA GGCCCCCCCC UCCCGGGAGA SEQ ID NO: 8 GCCAUAGUGG UCUGCGGAACCGGUGAGUAC ACCGGAAUUG CCGGGAAGAC UGGGUCCUUU CUUGGAUAAA CCCACUCUAUGCCCGGCCAU UUGGGCGUGC CCCCGCAAGA CUGCUAGCCG AGUAGUGUUG GGUUGCG HUMAN AAUUAUUGGUUAAAGAAGUAUAUUAGUGCUAAUUUCCCUCCG SEQ ID NO: 9 ALBUMIN UUUGUCCUAGCUUUUCUCUUCUGUCAACCCCACACGCCUUUGG CACA EMCV CUCCCUCCCC CCCCCCUAAC GUUACUGGCC GAAGCCGCUU SEQ ID NO: 10 GGAAUAAGGC CGGUGUGCGU UUGUCUAUAU GUUAUUUUCC ACCAUAUUGC CGUCUUUUGG CAAUGUGAGG GCCCGGAAAC CUGGCCCUGU CUUCUUGACG AGCAUUCCUA GGGGUCUUUC CCCUCUCGCC AAAGGAAUGC AAGGUCUGUU GAAUGUCGUG AAGGAAGCAG UUCCUCUGGA AGCUUCUUGA AGACAAACAA CGUCUGUAGC GACCCUUUGC AGGCAGCGGA ACCCCCCACC UGGCGACAGG UGCCUCUGCG GCCAAAAGCC ACGUGUAUAA GAUACACCUG CAAAGGCGGC ACAACCCCAG UGCCACGUUG UGAGUUGGAU AGUUGUGGAA AGAGUCAAAU GGCUCUCCUC AAGCGUAUUC AACAAGGGGC UGAAGGAUGC CCAGAAGGUA CCCCAUUGUA UGGGAUCUGA UCUGGGGCCU CGGUGCACAU GCUUUACGUG UGUUUAGUCG AGGUUAAAAA ACGUCUAGGC CCCCCGAACC ACGGGGACGU GGUUUUCCUU UGAAAAACAC GAUGAUAAU AT1G67090 CACAAAGAGUAAAGAAGAACA SEQ ID NO: 125 AT1G35720 AACACUAAAAGUAGAAGAAAA SEQ ID NO: 126 AT5G45900 CUCAGAAAGAUAAGAUCAGCC SEQ ID NO: 127 AT5G61250 AACCAAUCGAAAGAAACCAAA SEQ ID NO: 230 AT5G46430 CUCUAAUCACCAGGAGUAAAA SEQ ID NO: 231 AT5G47110 GAGAGAGAUCUUAACAAAAAA SEQ ID NO: 232 AT1G03110 UGUGUAACAACAACAACAACA SEQ ID NO: 233 AT3G12380 CCGCAGUAGGAAGAGAAAGCC SEQ ID NO: 234 AT5G45910 AAAAAAAAAAGAAAUCAUAAA SEQ ID NO: 235 AT1G07260 GAGAGAAGAAAGAAGAAGACG SEQ ID NO: 236 AT3G55500 CAAUUAAAAAUACUUACCAAA SEQ ID NO: 237 AT3G46230 GCAAACAGAGUAAGCGAAACG SEQ ID NO: 238 AT2G36170 GCGAAGAAGACGAACGCAAAG SEQ ID NO: 239 AT1G10660 UUAGGACUGUAUUGACUGGCC SEQ ID NO: 240 AT4G14340 AUCAUCGGAAUUCGGAAAAAG SEQ ID NO: 241 AT1G49310 AAAACAAAAGUUAAAGCAGAC SEQ ID NO: 242 AT4G14360 UUUAUCUCAAAUAAGAAGGCA SEQ ID NO: 243 AT1G28520 GGUGGGGAGGUGAGAUUUCUU SEQ ID NO: 244 AT1G20160 UGAUUAGGAAACUACAAAGCC SEQ ID NO: 245 AT5G37370 CAUUUUUCAAUUUCAUAAAAC SEQ ID NO: 246 AT4G11320 UUACUUUUAAGCCCAACAAAA SEQ ID NO: 247 AT5G40850 GGCGUGUGUGUGUGUUGUUGA SEQ ID NO: 248 AT1G06150 GUGGUGAAGGGGAAGGUUUAG SEQ ID NO: 249 AT2G26080 UUGUUUUUUUUUGGUUUGGUU SEQ ID NO: 250
[0063] Preferably the 5′UTR sequence comprises SEQ ID NO: 6 (AT1G58420).
[0064] Preferably, an mRNA described herein comprises a translation enhancer sequence. Translation enhancer sequences enhance the translation efficiency of a mRNA described herein and thereby provide increased production of the protein encoded by the mRNA. The translation enhancer region may be located in the 5′ or 3′ UTR of an mRNA sequence. Examples of translation enhancer regions include naturally-occurring enhancer regions from TEV 5′UTR and Xenopus beta-globin 3′UTR. Preferred 5′ UTR enhancer sequences include but are not limited to those derived from mRNAs encoding human heat shock proteins (HSP) including HSP70-P2, HSP70-M1 HSP72-M2, HSP17.9 and HSP70-P1. Preferred translation enhancer sequences used in accordance with the embodiments of the present disclosure are represented by SEQ ID NOS: 11-15 as shown in Table 3.
TABLE-US-00003 TABLE 3 5′ UTR enhancers Name Sequence Seq ID No.: HSP70-P2 GUCAGCUUUCAAACUCUUUG SEQ ID NO: 11 UUUCUUGUUUGUUGAUUGAG AAUA HSP70-M1 CUCUCGCCUGAGAAAAAAAA SEQ ID NO: 12 UCCACGAACCAAUUUCUCAG CAACCAGCAGCACG HSP72-M2 ACCUGUGAGGGUUCGAAGGA SEQ ID NO: 13 AGUAGCAGUGUUUUUUGUUC CUAGAGGAAGAG HSP17.9 ACACAGAAACAUUCGCAAAA SEQ ID NO: 14 ACAAAAUCCCAGUAUCAAAA UUCUUCUCUUUUUUUCAUAU UUCGCAAAGAC HSP70-P1 CAGAAAAAUUUGCUACAUUG SEQ ID NO: 15 UUUCACAAACUUCAAAUAUU AUUCAUUUAUUU
[0065] Preferably, an mRNA described herein comprises a Kozak sequence. As is understood in the art, a Kozak sequence is a short consensus sequence centered around the translational initiation site of eukaryotic mRNAs that allows for efficient initiation of translation of the mRNA. The ribosomal translation machinery recognizes the AUG initiation codon in the context of the Kozak sequence. A Kozak sequence, may be inserted upstream of the coding sequence for the therapeutic protein of interest, downstream of a 5′ UTR or inserted upstream of the coding sequence for the therapeutic protein of interest and downstream of a 5′ UTR. Preferably, an mRNA described herein comprises a Kozak sequence having the amino acid sequence GCCACC (SEQ ID NO: 23). Preferably an mRNA described herein comprises a partial Kozak sequence “p” having the amino acid sequence GCCA (SEQ ID NO: 24).
[0066] Preferably an mRNA described herein comprises a 3′UTR. Preferably, the 3′ UTR comprises a sequence selected from the 3′ UTRs of alanine aminotransferase 1, human apolipoprotein E, human fibrinogen alpha chain, human haptoglobin, human antithrombin, human alpha globin, human beta globin, human complement C3, human growth factor, human hepcidin, MALAT-1, mouse beta globin, mouse albumin, and Xenopus beta globin, or fragments of any of the foregoing. Preferably, the 3′ UTR is derived from Xenopus beta globin. Preferred 3′ UTR sequences include SEQ ID NOS 16-22 as shown in Table 4.
TABLE-US-00004 TABLE 4 3′ UTR sequences Name Sequence Seq ID No.: XBG CUAGUGACUGACUAGGAUCUGGUU SEQ ID NO: 16 ACCACUAAACCAGCCUCAAGAACA CCCGAAUGGAGUCUCUAAGCUACA UAAUACCAACUUACACUUACAAAA UGUUGUCCCCCAAAAUGUAGCCAU UCGUAUCUGCUCCUAAUAAAAAGA AAGUUUCUUCACAU HUMAN UGCAAGGCUGGCCGGAAGCCCUUG SEQ ID NO: 17 HAPTOGLOBIN CCUGAAAGCAAGAUUUCAGCCUGG AAGAGGGCAAAGUGGACGGGAGUG GACAGGAGUGGAUGCGAUAAGAUG UGGUUUGAAGCUGAUGGGUGCCAG CCCUGCAUUGCUGAGUCAAUCAAU AAAGAGCUUUCUUUUGACCCAU HUMAN ACGCCGAAGCCUGCAGCCAUGCGA SEQ ID NO: 18 APOLIPO- CCCCACGCCACCCCGUGCCUCCUG PROTEIN E CCUCCGCGCAGCCUGCAGCGGGAG ACCCUGUCCCCGCCCCAGCCGUCC UCCUGGGGUGGACCCUAGUUUAAU AAAGAUUCACCAAGUUUCACGCA HCV UAGAGCGGCAAACCCUAGCUACAC SEQ ID NO: 19 UCCAUAGCUAGUUUCUUUUUUUUU UGUUUUUUUUUUUUUUUUUUUUUU UUUUUUUUUUUUUUUUUCCUUUCU UUUCCUUCUUUUUUUCCUCUUUUC UUGGUGGCUCCAUCUUAGCCCUAG UCACGGCUAGCUGUGAAAGGUCCG UGAGCCGCAUGACUGCAGAGAGUG CCGUAACUGGUCUCUCUGCAGAUC AUGU MOUSE ACACAUCACAACCACAACCUUCUC SEQ ID NO: 20 ALBUMIN AGGCUACCCUGAGAAAAAAAGACA UGAAGACUCAGGACUCAUCUUUUC UGUUGGUGUAAAAUCAACACCCUA AGGAACACAAAUUUCUUUAAACAU UUGACUUCUUGUCUCUGUGCUGCA AUUAAUAAAAAAUGGAAAGAAUCU AC HUMAN ALPHA GCUGGAGCCUCGGUAGCCGUUCCU SEQ ID NO: 21 GLOBIN CCUGCCCGCUGGGCCUCCCAACGG GCCCUCCUCCCCUCCUUGCACCGG CCCUUCCUGGUCUUUGAAUAAAGU CUGAGUGGGCAGCA EMCV UAGUGCAGUCAC UGGCACAACG SEQ ID NO: 22 CGUUGCCCGG UAAGCCAAUC GGGUAUACAC GGUCGUCAUACUGCAGACAG GGUUCUUCUA CUUUGCAAGA UAGUCUAGAG UAGUAAAAUA AAUAGUAUAAG
[0067] Preferably, an mRNA described herein comprises a 3′ tail region, which can serve to protect the mRNA from exonuclease degradation. The tail region may be a 3′poly(A) and/or 3′poly(C) region. Preferably, the tail region is a 3′ poly(A) tail. As used herein a “3′ poly(A) tail” is a polymer of sequential adenine nucleotides that can range in size from, for example: 10 to 250 sequential adenine nucleotides; 60-125 sequential adenine nucleotides, 90-125 sequential adenine nucleotides, 95-125 sequential adenine nucleotides, 95-121 sequential adenine nucleotides, 100 to 121 sequential adenine nucleotides, 110-121 sequential adenine nucleotides; sequential adenine nucleotides, 112-121 sequential adenine nucleotides; 114-121 adenine sequential nucleotides; and 115 to 121 sequential adenine nucleotides. Preferably a 3′ poly A tail as described herein comprise is 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, or 125 sequential adenine nucleotides. 3′ Poly(A) tails can be added using a variety of methods known in the art, e.g., using poly(A) polymerase to add tails to synthetic or in vitro transcribed RNA. Other methods include the use of a transcription vector to encode poly A tails or the use of a ligase (e.g., via splint ligation using a T4 RNA ligase and/or T4 DNA ligase), wherein poly(A) may be ligated to the 3′ end of a sense RNA. Preferably, a combination of any of the above methods is utilized.
[0068] Preferably, an mRNA described herein comprises a 5′ cap. 5′-ends capped with various groups and their analogues are known in the art. The 5′ cap may be selected from m7GpppA, m7GpppC; unmethylated cap analogs (e.g., GpppG); dimethylated cap analog (e.g., m2,7GpppG), a trimethylated cap analog (e.g., m2,2,7GpppG), dimethylated symmetrical cap analogs (e.g., m7Gpppm7G), or anti reverse cap analogs (e.g., ARCA; m7, 2′OmeGpppG, m72′dGpppG, m7,3′OmeGpppG, m7,3′dGpppG and their tetraphosphate derivatives) (see, e.g., Jemielity, J. et al., RNA 9: 1108-1122 (2003). The 5′ cap may be an ARCA cap (3′-OMe-m7G(5′)pppG). The 5′ cap may be an mCAP (m7G(5′)ppp(5′)G, N7-Methyl-Guanosine-5′-Triphosphate-5′-Guanosine). The 5′ cap may be resistant to hydrolysis. A preferred 5′ cap is referred to herein as “m7GpppGm cap” also referred to herein as “Cap1” and has the following core structure:
##STR00001##
[0069] Preferably an mRNA described herein comprises one or more chemically modified nucleotides. Examples of nucleic acid monomers include non-natural, modified, and chemically-modified nucleotides, including any such nucleotides known in the art. mRNA sequences comprising chemically modified nucleotides have been shown to improve mRNA expression, expression rates, half-life and/or expressed protein concentrations. mRNA sequences comprising chemically modified nucleotides have also been useful to optimize protein localization thereby avoiding deleterious bio-responses such as the immune response and/or degradation pathways.
[0070] Examples of modified or chemically-modified nucleotides include 5-hydroxycytidines, 5-alkylcytidines, 5-hydroxyalkylcytidines, 5-carboxycytidines, 5-formylcytidines, 5-alkoxycytidines, 5-alkynylcytidines, 5-halocytidines, 2-thiocytidines, N.sup.4-alkylcytidines, N.sup.4-aminocytidines, N.sup.4-acetylcytidines, and N.sup.4,N.sup.4-dialkylcytidines.
[0071] Examples of modified or chemically-modified nucleotides include 5-hydroxycytidine, 5-methylcytidine, 5-hydroxymethylcytidine, 5-carboxycytidine, 5-formylcytidine, 5-methoxycytidine, 5-propynylcytidine, 5-bromocytidine, 5-iodocytidine, 2-thiocytidine; N4-methylcytidine, N4-aminocytidine, N4-acetylcytidine, and N4,N4-dimethylcytidine.
[0072] Examples of modified or chemically-modified nucleotides include 5-hydroxyuridines, 5-alkyluridines, 5-hydroxyalkyluridines, 5-carboxyuridines, 5-carboxyalkylesteruridines, 5-formyluridines, 5-alkoxyuridines, 5-alkynyluridines, 5-halouridines, 2-thiouridines, and 6-alkyluridines.
[0073] Examples of modified or chemically-modified nucleotides include 5-hydroxyuridine, 5-methyluridine, 5-hydroxymethyluridine, 5-carboxyuridine, 5-carboxymethylesteruridine, 5-formyluridine, 5-methoxyuridine (also referred to herein as “5MeOU”), 5-propynyluridine, 5-bromouridine, 5-fluorouridine, 5-iodouridine, 2-thiouridine, and 6-methyluridine.
[0074] Examples of modified or chemically-modified nucleotides include 5-methoxycarbonylmethyl-2-thiouridine, 5-methylaminomethyl-2-thiouridine, 5-carbamoylmethyluridine, 5-carbamoylmethyl-2′-O-methyluridine, 1-methyl-3-(3-amino-3-carboxypropy)pseudouridine, 5-methylaminomethyl-2-selenouridine, 5-carboxymethyluridine, 5-methyldihydrouridine, 5-taurinomethyluridine, 5-taurinomethyl-2-thiouridine, 5-(isopentenylaminomethyl)uridine, 2′-O-methylpseudouridine, 2-thio-2′O-methyluridine, and 3,2′-O-dimethyluridine.
[0075] Examples of modified or chemically-modified nucleotides include N6-methyladenosine, 2-aminoadenosine, 3-methyladenosine, 8-azaadenosine, 7-deazaadenosine, 8-oxoadenosine, 8-bromoadenosine, 2-methylthio-N6-methyladenosine, N6-isopentenyladenosine, 2-methylthio-N6-isopentenyladenosine, N6-(cis-hydroxyisopentenyl)adenosine, 2-methylthio-N6-(cis-hydroxyisopentenyl)adenosine, N6-glycinylcarbamoyladenosine, N6-threonylcarbamoyl-adenosine, N6-methyl-N6-threonylcarbamoyl-adenosine, 2-methylthio-N6-threonylcarbamoyl-adenosine, N6,N6-dimethyladenosine, N6-hydroxynorvalylcarbamoyladenosine, 2-methylthio-N6-hydroxynorvalylcarbamoyl-adenosine, N6-acetyl-adenosine, 7-methyl-adenine, 2-methylthio-adenine, 2-methoxy-adenine, alpha-thio-adenosine, 2′-O-methyl-adenosine, N6,2′-O-dimethyl-adenosine, N6,N6,2′-O-trimethyl-adenosine, 1,2′-O-dimethyl-adenosine, 2′-O-ribosyladenosine, 2-amino-N6-methyl-purine, 1-thio-adenosine, 2′-F-ara-adenosine, 2′-F-adenosine, 2′-OH-ara-adenosine, and N6-(19-amino-pentaoxanonadecyl)-adenosine.
[0076] Examples of modified or chemically-modified nucleotides include N1-alkylguanosines, N2-alkylguanosines, thienoguanosines, 7-deazaguanosines, 8-oxoguanosines, 8-bromoguanosines, 06-alkylguanosines, xanthosines, inosines, and N1-alkylinosines.
[0077] Examples of modified or chemically-modified nucleotides include N1-methylguanosine, N2-methylguanosine, thienoguanosine, 7-deazaguanosine, 8-oxoguanosine, 8-bromoguanosine, 06-methylguanosine, xanthosine, inosine, and N1-methylinosine.
[0078] Examples of modified or chemically-modified nucleotides include pseudouridines. Examples of pseudouridines include N1-alkylpseudouridines, N1-cycloalkylpseudouridines, N1-hydroxypseudouridines, N1-hydroxyalkylpseudouridines, N1-phenylpseudouridines, N1-phenylalkylpseudouridines, N1-aminoalkylpseudouridines, N3-alkylpseudouridines, N6-alkylpseudouridines, N6-alkoxypseudouridines, N6-hydroxypseudouridines, N6-hydroxyalkylpseudouridines, N6-morpholinopseudouridines, N6-phenylpseudouridines, and N6-halopseudouridines. Examples of pseudouridines include N1-alkyl-N6-alkylpseudouridines, N1-alkyl-N6-alkoxypseudouridines, N1-alkyl-N6-hydroxypseudouridines, N1-alkyl-N6-hydroxyalkylpseudouridines, N1-alkyl-N6-morpholinopseudouridines, N1-alkyl-N6-phenylpseudouridines, and N1-alkyl-N6-halopseudouridines. In these examples, the alkyl, cycloalkyl, and phenyl substituents may be unsubstituted, or further substituted with alkyl, halo, haloalkyl, amino, or nitro substituents.
[0079] Examples of pseudouridines include N1-methylpseudouridine (also referred to herein as “N1MPU”), N1-ethylpseudouridine, N1-propylpseudouridine, N1-cyclopropylpseudouridine, N1-phenylpseudouridine, N1-aminomethylpseudouridine, N3-methylpseudouridine, N1-hydroxypseudouridine, and N1-hydroxymethylpseudouridine.
[0080] Examples of nucleic acid monomers include modified and chemically-modified nucleotides, including any such nucleotides known in the art.
[0081] Examples of modified and chemically-modified nucleotide monomers include any such nucleotides known in the art, for example, 2′-O-methyl ribonucleotides, 2′-O-methyl purine nucleotides, 2′-deoxy-2′-fluoro ribonucleotides, 2′-deoxy-2′-fluoro pyrimidine nucleotides, 2′-deoxy ribonucleotides, 2′-deoxy purine nucleotides, universal base nucleotides, 5-C-methyl-nucleotides, and inverted deoxyabasic monomer residues.
[0082] Examples of modified and chemically-modified nucleotide monomers include 3′-end stabilized nucleotides, 3′-glyceryl nucleotides, 3′-inverted abasic nucleotides, and 3′-inverted thymidine.
[0083] Examples of modified and chemically-modified nucleotide monomers include locked nucleic acid nucleotides (LNA), 2′-0,4′-C-methylene-(D-ribofuranosyl) nucleotides, 2′-methoxyethoxy (MOE) nucleotides, 2′-methyl-thio-ethyl, 2′-deoxy-2′-fluoro nucleotides, and 2′-O-methyl nucleotides. In an exemplary embodiment, the modified monomer is a locked nucleic acid nucleotide (LNA).
[0084] Examples of modified and chemically-modified nucleotide monomers include 2′,4′-constrained 2′-O-methoxyethyl (cMOE) and 2′-O-Ethyl (cEt) modified DNAs.
[0085] Examples of modified and chemically-modified nucleotide monomers include 2′-amino nucleotides, 2′-O-amino nucleotides, 2′-C-allyl nucleotides, and 2′-O-allyl nucleotides.
[0086] Examples of modified and chemically-modified nucleotide monomers include N6-methyladenosine nucleotides.
[0087] Examples of modified and chemically-modified nucleotide monomers include nucleotide monomers with modified bases 5-(3-amino)propyluridine, 5-(2-mercapto)ethyluridine, 5-bromouridine; 8-bromoguanosine, or 7-deazaadenosine.
[0088] Examples of modified and chemically-modified nucleotide monomers include 2′-O-aminopropyl substituted nucleotides.
[0089] Examples of modified and chemically-modified nucleotide monomers include replacing the 2′-OH group of a nucleotide with a 2′-R, a 2′-OR, a 2′-halogen, a 2′-SR, or a 2′-amino, where R can be H, alkyl, alkenyl, or alkynyl.
[0090] Example of base modifications described above can be combined with additional modifications of nucleoside or nucleotide structure, including sugar modifications and linkage modifications. Certain modified or chemically-modified nucleotide monomers may be found in nature.
[0091] Preferred nucleotide modifications include N.sup.1-methylpseudouridine and 5-methoxyuridine. The constructs for preferred mRNA sequences are provided in Table 5.
TABLE-US-00005 TABLE 5 Exemplary mRNA Constructs mRNA mRNA Construct Therapeutic 3′ Poly Construct No. Cap 5′UTR Kozak* Protein ORF 3′UTR A Tail SEQ ID NO: 563 Cap1 TEV Yes ORF XBG Yes 26 Sequence 564 Cap1 TEV Yes ORF XBG Yes 27 Sequence 565 Cap1 TEV Yes ORF XBG Yes 28 Sequence 566 Cap1 TEV Yes SEQ ID NO: 3 XBG Yes 29 567 Cap1 TEV Yes SEQ ID NO: 3 XBG Yes 30 568 Cap1 TEV Yes SEQ ID NO: 3 XBG Yes 31 569 Cap1 TEV Yes SEQ ID NO: 3 XBG Yes 32 570 Cap1 TEV Yes ORF XBG Yes 33 SEQUENCE 571 Cap1 TEV Yes ORF XBG Yes 34 SEQUENCE 572 Cap1 TEV Yes ORF XBG Yes 35 SEQUENCE 573 Cap1 TEV Yes ORF XBG Yes 36 SEQUENCE 574 Cap1 TEV Yes ORF XBG Yes 37 SEQUENCE 575 Cap1 TEV P ORF XBG Yes 38 SEQUENCE 708 Cap1 TEV P ORF XBG Yes 39 SEQUENCE 709 Cap1 TEV P ORF XBG Yes 40 SEQUENCE 710 Cap1 TEV P ORF XBG Yes 41 SEQUENCE 711 Cap1 TEV P ORF XBG Yes 42 SEQUENCE 712 Cap1 TEV Yes ORF XBG Yes 43 SEQUENCE 713 Cap1 TEV Yes ORF XBG Yes 44 SEQUENCE 714 Cap1 TEV Yes ORF XBG Yes 45 SEQUENCE 715 Cap1 TEV Yes ORF XBG Yes 46 SEQUENCE 716 Cap1 TEV Yes ORF XBG Yes 47 SEQUENCE 717 Cap1 TEV Yes ORF XBG Yes 48 SEQUENCE 718 Cap1 TEV Yes ORF XBG Yes 49 SEQUENCE 719 Cap1 TEV Yes ORF XBG Yes 50 SEQUENCE 720 Cap1 TEV Yes ORF XBG Yes 51 SEQUENCE 721 Cap1 TEV Yes ORF XBG Yes 52 SEQUENCE 722 Cap1 TEV Yes ORF XBG Yes 53 SEQUENCE 723 Cap1 TEV Yes ORF XBG Yes 54 SEQUENCE 724 Cap1 TEV Yes ORF XBG Yes 55 SEQUENCE 725 Cap1 TEV Yes ORF XBG Yes 56 SEQUENCE 726 Cap1 TEV Yes ORF XBG Yes 57 SEQUENCE 727 Cap1 TEV Yes ORF XBG Yes 58 SEQUENCE 728 Cap1 TEV Yes ORF XBG Yes 59 SEQUENCE 729 Cap1 TEV Yes ORF XBG Yes 60 SEQUENCE 1787 Cap1 ARC5-2 No ORF Hu haptoglob Yes 61 SEQUENCE 1788 Cap1 AT1G58420 P ORF Hu ApoE Yes 62 SEQUENCE 1789 Cap1 ARC5-2 No ORF Hu haptoglob Yes 63 SEQUENCE 1790 Cap1 AT1G58420 P ORF Hu ApoE Yes 64 SEQUENCE 1791 Cap1 ARC5-2 No ORF Hu haptoglob Yes 65 SEQUENCE 1792 Cap1 HCV5′ P ORF HCV3′ Yes 66 SEQUENCE 1793 Cap1 AT1G58420 P ORF Hu a-glob Yes 67 SEQUENCE 1794 Cap1 AT1G58420 P ORF Hu a-glob Yes 68 SEQUENCE 1795 Cap1 AT1G58420 P ORF Hu a-glob Yes 69 SEQUENCE 1796 Cap1 Hu alb No ORF Ms Alb Yes 70 SEQUENCE 1797 Cap1 Hu alb No ORF Ms Alb Yes 71 SEQUENCE 1798 Cap1 Hu alb No ORF Ms Alb Yes 72 SEQUENCE 1799 Cap1 AT1G58420 Yes ORF Hu a-glob Yes 73 SEQUENCE 1800 Cap1 Hu alb No ORF Ms Alb Yes 74 SEQUENCE 1801 Cap1 AT1G58420 P ORF Hu ApoE Yes 75 SEQUENCE 1802 Cap1 ARC5-2 No ORF Hu haptoglob Yes 76 SEQUENCE 1803 Cap1 TEV Yes ORF XBG Yes 77 SEQUENCE 1804 Cap1 TEV Yes ORF XBG Yes 78 SEQUENCE 1805 Cap1 TEV Yes ORF XBG Yes 79 SEQUENCE 1806 Cap1 TEV Yes ORF XBG Yes 80 SEQUENCE 1808 Cap1 TEV Yes ORF XBG Yes 81 SEQUENCE 1809 Cap1 TEV Yes ORF XBG Yes 82 SEQUENCE 1816 Cap1 TEV P ORF XBG Yes 83 SEQUENCE 1822 Cap1 TEV Yes ORF XBG Yes 84 SEQUENCE 1823 Cap1 TEV Yes ORF XBG Yes 85 SEQUENCE 1840 Cap1 EMCV No ORF EMCV Yes 86 SEQUENCE 1841 Cap1 EMCV No ORF EMCV Yes 87 SEQUENCE 1842 Cap1 EMCV No ORF EMCV Yes 88 SEQUENCE 1843 Cap1 HSP70-P2- Yes ORF XBG Yes 89 TEV SEQUENCE 1844 Cap1 HSP70-M1- Yes ORF XBG Yes 90 TEV SEQUENCE 1845 Cap1 HSP70-M2- Yes ORF XBG Yes 91 TEV SEQUENCE 1846 Cap1 HSP17.9- Yes ORF XBG Yes 92 TEV SEQUENCE 1847 Cap1 HSP70-P1- Yes ORF XBG Yes 93 TEV SEQUENCE 1882 Cap1 TEV Yes ORF XBG Yes 94 SEQUENCE 1883 Cap1 TEV Yes ORF XBG Yes 95 SEQUENCE 1884 Cap1 TEV Yes ORF XBG Yes 96 SEQUENCE 1885 Cap1 TEV Yes ORF XBG Yes 97 SEQUENCE 1886 Cap1 TEV Yes ORF XBG Yes 98 SEQUENCE 1887 Cap1 TEV Yes ORF XBG Yes 99 SEQUENCE 1888 Cap1 TEV Yes ORF XBG Yes 100 SEQUENCE 1889 Cap1 TEV Yes ORF XBG Yes 101 SEQUENCE 1890 Cap1 TEV Yes ORF XBG Yes 102 SEQUENCE 1891 Cap1 TEV Yes ORF XBG Yes 103 SEQUENCE 1898 Cap1 TEV Yes ORF XBG Yes 104 SEQUENCE 1899 Cap1 TEV Yes ORF XBG Yes 105 SEQUENCE 1900 Cap1 TEV Yes ORF XBG Yes 106 SEQUENCE 1903 Cap1 TEV P ORF XBG Yes 107 SEQUENCE 1904 Cap1 TEV P ORF XBG Yes 108 SEQUENCE 1905 Cap1 TEV P ORF XBG Yes 109 SEQUENCE 1906 Cap1 TEV P ORF XBG Yes 110 SEQUENCE 1907 Cap1 TEV P ORF XBG Yes 111 SEQUENCE 1908 Cap1 TEV P ORF XBG Yes 112 SEQUENCE 1915 Cap1 HSP70-P1- Yes ORF Hu a-glob Yes 113 AT1G58420 SEQUENCE 1916 Cap1 HSP70-P1- Yes ORF Hu a-glob Yes 114 AT1G58420 SEQUENCE 1917 Cap1 HSP70-P1- Yes ORF Hu a-glob Yes 115 AT1G58420 SEQUENCE 1918 Cap1 HSP70-P1- Yes ORF Hu a-glob Yes 116 AT1G58420 SEQUENCE 1919 Cap1 AT1G58420 Yes ORF Hu a-glob Yes 117 SEQUENCE 1920 Cap1 AT1G58420 Yes ORF Hu a-glob Yes 118 SEQUENCE 1921 Cap1 AT1G58420 Yes SEQ ID NO: Hu a-glob Yes 119 4** 1925 Cap1 TEV Yes ORF XBG Yes 120 SEQUENCE 1926 Cap1 AT1G58420 Yes ORF Hu a-glob Yes 121 SEQUENCE 1927 Cap1 AT1G58420 Yes ORF Hu a-glob Yes 122 SEQUENCE 1928 Cap1 AT1G58420 Yes ORF Hu a-glob Yes 123 SEQUENCE 1929 Cap1 HSP70-P1- Yes ORF Hu a-glob Yes 124 AT1G58420 SEQUENCE 2016 Cap1 AT1G58420 Yes ORF Hu a-glob Yes 73 SEQUENCE 2260 Cap1 AT1G58420 Yes SEQ ID NO: Hu a-glob Yes 119 4** 2262 Cap1 AT1G58420 Yes SEQ IS NO: Hu a-glob Yes 119 4** *Kozak sequence defined as GCCACC (SEQ ID NO: 23). Partial (P) Kozak defined as GCCA (SEQ ID NO: 24). **Construct encodes modified human OTC protein of SEQ ID NO: 4.
[0092] Preferred mRNA sequences include all of the mRNA sequences listed in Table 5. Preferred mRNA sequences include all of the mRNA sequences listed wherein, 0% to 100%, preferably 1% to 100%, preferably 25% to 100%, preferably 50% to 100% and preferably 75% to 100% of the uracil nucleotides of the mRNA sequences are modified. Preferably, 1% to 100% of the uracil nucleotides are N1-methylpseudouridine or 5-methoxyuridine. Preferably 100% of the uracil nucleotides are N1-methylpseudouridine. Preferably 100% of the uracil nucleotides are 5-methoxyuridine.
[0093] Preferred mRNA sequences comprise a 5′ cap, a 5′UTR that is derived from a gene expressed by Arabidopsis thaliana, an optional translation enhancer sequence, an optional Kozak sequence or partial Kozak sequence, a codon optimized coding sequence (CDS/ORF) coding for a human protein of interest, a 3′ UTR and a poly A tail. Preferably, the 5′ UTR that is derived from a gene expressed by Arabidopsis thaliana is selected from found in Table 5. Preferably, the 5′ UTR that is derived from a gene expressed by Arabidopsis thaliana is selected from the group consisting of: SEQ ID NO: 6, SEQ ID NOS: 125-127 and SEQ ID NOS: 227-247. Preferably the 5′ UTR sequence is AT1G58420 having the sequence of SEQ ID NO: 6. Preferably, the uracil content of the codon optimized sequence has been reduced with respect to the percentages of uracil content of SEQ ID NO: 1. Preferably, 0% to 100% of the uracil nucleotides of the mRNA sequences are modified. Preferably, 0% to 100% of the uracil nucleotides are N1-methylpseudouridine or 5-methoxyuridine. Preferably 100% of the uracil nucleotides are N1-methylpseudouridine. Preferably 100% of the uracil nucleotides are 5-methoxyuridine.
[0094] Preferred mRNA constructs comprise codon optimized coding sequences and a 5′ UTR from a gene expressed by Arabidopsis thaliana and are selected from: SEQ ID NOS: 62, 67, 68, 69, 73, 113-119, 121-127.
[0095] An exemplary mRNA sequences includes the mRNA construct having a codon optimized ORF encoding modified OTC of SEQ ID NO: 4.
[0096] Preferably 100% of the uridine nucleotides of mRNA constructs 1799 (SEQ ID NO:73) and 1921 (SEQ ID NO:119), are N1-methylpseudouridine. Preferably 100% of the uracil nucleotides of mRNA constructs 1799 (SEQ ID NO:73), and 1921 (SEQ ID NO:119), are 5-methoxyuridine.
[0097] Design and Synthesis of the mRNA Sequences
[0098] mRNA for use in accordance with the disclosure may be prepared according to any available technique including, but not limited to chemical synthesis, in vitro transcription (IVT) or enzymatic or chemical cleavage of a longer precursor, etc. Methods of synthesizing RNAs are known in the art.
[0099] In some embodiments, mRNA is produced from a primary complementary DNA (cDNA) construct. The process of design and synthesis of the primary cDNA constructs described herein generally includes the steps of gene construction, mRNA production (either with or without modifications) and purification. In the IVT method, a target polynucleotide sequence encoding the modified therapeutic protein of interest is first selected for incorporation into a vector which will be amplified to produce a cDNA template. Optionally, the target polynucleotide sequence and/or any flanking sequences may be codon optimized. The cDNA template is then used to produce mRNA through in vitro transcription (IVT). After production, the mRNA may undergo purification and clean-up processes. The steps of which are provided in more detail below.
[0100] The step of gene construction may include, but is not limited to gene synthesis, vector amplification, plasmid purification, plasmid linearization and clean-up, and cDNA template synthesis and clean-up. Once a modified protein (e.g. SEQ ID NO: 4) is selected for production, a primary construct is designed. Within the primary construct, a first region of linked nucleosides encoding the polypeptide of interest may be constructed using an open reading frame (ORF) of a selected nucleic acid (DNA or RNA) transcript. The ORF may comprise the wild type ORF, an isoform, variant or a fragment thereof. As used herein, an “open reading frame” or “ORF” is meant to refer to a nucleic acid sequence (DNA or RNA) which is capable of encoding a polypeptide of interest. ORFs often begin with the start codon, ATG and end with a nonsense or termination codon or signal.
[0101] Further, nucleotide sequence of any region of the mRNA or DNA template may be codon optimized. Codon optimization methods are known in the art and may be useful in efforts to achieve one or more of several goals. These goals include to match codon frequencies in target and host organisms to ensure proper folding, to bias GC content to increase mRNA stability or reduce secondary structures, to minimize tandem repeat codons or base runs that may impair gene construction or expression, to customize transcriptional and translational control regions, to insert or remove protein trafficking sequences, to remove/add post translation modification sites in encoded protein (e.g. glycosylation sites), to add, remove or shuffle protein domains, to insert or delete restriction sites, to modify ribosome binding sites and mRNA degradation sites, to adjust translational rates to allow the various domains of the protein to fold properly, or to reduce or eliminate problematic secondary structures within the mRNA. Suitable codon optimization tools, algorithms and services are known in the art.
[0102] Preferably, the primary cDNA template may include reducing the occurrence or frequency of appearance of certain nucleotides in the template strand. For example, the occurrence of a nucleotide in a template may be reduced to a level below 25% of nucleotides in the template. In further examples, the occurrence of a nucleotide in a template may be reduced to a level below 20% of nucleotides in the template. In some examples, the occurrence of a nucleotide in a template may be reduced to a level below 16% of nucleotides in the template. Preferably, the occurrence of a nucleotide in a template may be reduced to a level below 15%, and preferably may be reduced to a level below 12% of nucleotides in the template.
[0103] For example, the present disclosure provides nucleic acids wherein with altered uracil content at least one codon in the wild-type sequence has been replaced with an alternative codon to generate a uracil-altered sequence. Altered uracil sequences can have at least one of the following properties:
[0104] (i) an increase or decrease in global uracil content (i.e., the percentage of uracil of the total nucleotide content in the nucleic acid of a section of the nucleic acid, e.g., the open reading frame); or,
[0105] (ii) an increase or decrease in local uracil content (i.e., changes in uracil content are limited to specific subsequences); or,
[0106] (iii) a change in uracil distribution without a change in the global uracil content; or,
[0107] (iv) a change in uracil clustering (e.g., number of clusters, location of clusters, or distance between clusters); or,
[0108] (v) combinations thereof.
[0109] Preferably, the percentage of uracil nucleobases in the nucleic acid sequence is reduced with respect to the percentage of uracil nucleobases in the wild-type nucleic acid sequence. For example, 30% of nucleobases may be uracil in the wild-type sequence but the nucleobases that are uracil are preferably lower than 15%, preferably lower than 12% and preferably lower than 10% of the nucleobases in the in the nucleic acid sequences of the disclosure. The percentage uracil content can be determined by dividing the number of uracil in a sequence by the total number of nucleotides and multiplying by 100.
[0110] Preferably, the percentage of uracil nucleobases in a subsequence of the nucleic acid sequence is reduced with respect to the percentage of uracil nucleobases in the corresponding subsequence of the wild-type sequence. For example, the wild-type sequence may have a 5′-end region (e.g., 30 codons) with a local uracil content of 30%, and the uracil content in that same region could be reduced to preferably 15% or lower, preferably 12% or lower and preferably 10% or lower in the nucleic acid sequences of the disclosure.
[0111] Preferably, codons in the nucleic acid sequence of the invention reduce or modify, for example, the number, size, location, or distribution of uracil clusters that could have deleterious effects on protein translation. Although lower uracil content is desirable, in certain aspects, the uracil content, and in particular the local uracil content, of some subsequences of the wild-type sequence can be greater than the wild-type sequence and still maintain beneficial features (e.g., increased expression).
[0112] Preferably, the uracil-modified sequence induces a lower Toll-Like Receptor (TLR) response when compared to the wild-type sequence. Several TLRs recognize and respond to nucleic acids. Double-stranded (ds)RNA, a frequent viral constituent, has been shown to activate TLR3. Single-stranded (ss)RNA activates TLR7. RNA oligonucleotides, for example RNA with phosphorothioate internucleotide linkages, are ligands of human TLR8. DNA containing unmethylated CpG motifs, characteristic of bacterial and viral DNA, activate TLR9.
[0113] As used herein, the term “TLR response” is defined as the recognition of single-stranded RNA by a TLR7 receptor, and preferably encompasses the degradation of the RNA and/or physiological responses caused by the recognition of the single-stranded RNA by the receptor. Methods to determine and quantify the binding of an RNA to a TLR7 are known in the art. Similarly, methods to determine whether an RNA has triggered a TLR7-mediated physiological response (e.g., cytokine secretion) are well known in the art. Preferably, a TLR response can be mediated by TLR3, TLR8, or TLR9 instead of TLR7. Suppression of TLR7-mediated response can be accomplished via nucleoside modification. RNA undergoes over a hundred different nucleoside modifications in nature. Human rRNA, for example, has ten times more pseudouracil ('P) and 25 times more 2′-O-methylated nucleosides than bacterial rRNA. Bacterial mRNA contains no nucleoside modifications, whereas mammalian mRNAs have modified nucleosides such as 5-methylcytidine (m5C), N6-methyladenosine (m6A), inosine and many 2′-O-methylated nucleosides in addition to N7-methylguanosine (m7G).
[0114] Preferably, the uracil content of polynucleotides disclosed herein and preferably polynucleotides encoding the modified therapeutic protein of interest is less than 50%, 49%, 48%, 47%, 46%, 45%, 44%, 43%, 42%, 41%, 40%, 39%, 38%, 37%, 36%, 35%, 34%, 33%, 32%, 31%, 30%, 29%, 28%, 27%, 26%, 25%, 24%, 23%, 22%, 21%, 20%, 19%, 18%, 7%1, 16%, 15%, 4%1, 3%1, 12%, 11%, 10%, 90%, 80%, 70%, 60%, 5%, 4%, 3%, 2% or 1% of the total nucleobases in the sequence in the reference sequence. Preferably, the uracil content of polynucleotides disclosed herein, is between about 5% and about 25%. Preferably, the uracil content of polynucleotides disclosed herein is about 15% and about 25%.
[0115] The cDNA templates may be transcribed to produce an mRNA sequence described herein using an in vitro transcription (IVT) system. The system typically comprises a transcription buffer, nucleotide triphosphates (NTPs), an RNase inhibitor and a polymerase. The NTPs may be selected from, but are not limited to, those described herein including natural and unnatural (modified) NTPs. The polymerase may be selected from, but is not limited to, T7 RNA polymerase, T3 RNA polymerase and mutant polymerases such as, but not limited to, polymerases able to incorporate modified nucleic acids.
[0116] The primary cDNA template or transcribed mRNA sequence may also undergo capping and/or tailing reactions. A capping reaction may be performed by methods known in the art to add a 5′ cap to the 5′ end of the primary construct. Methods for capping include, but are not limited to, using a Vaccinia Capping enzyme (New England Biolabs, Ipswich, Mass.) or CLEANCAP® technology (TriLink Biotechnologies). A poly-A tailing reaction may be performed by methods known in the art, such as, but not limited to, 2′ O-methyltransferase and by methods as described herein. If the primary construct generated from cDNA does not include a poly-T, it may be beneficial to perform the poly-A-tailing reaction before the primary construct is cleaned.
[0117] Codon optimized cDNA constructs encoding a modified therapeutic protein of interest are particularly suitable for generating mRNA sequences described herein. For example, such cDNA constructs may be used as the basis to transcribe, in vitro, a polyribonucleotide encoding a modified protein of interest. Table 6 provides a listing of exemplary cDNA ORF templates used for in vitro transcription of the mRNA sequences listed in Table 5.
TABLE-US-00006 TABLE 6 Exemplary cDNA Templates DNA Construct SEQ Protein encoded by No***: ID NO: cDNA template SEQ ID NO: p2260 221 SEQ ID NO: 4** p2262 221 SEQ ID NO: 4** **SEQ ID NO: 4 is the amino acid sequence for modified human OTC. ***The entire plasmid sequence is not included.
[0118] The present disclosure also provides polynucleotides (e.g. DNA, RNA, cDNA, mRNA) encoding a modified human protein of interest that may be operably linked to one or more regulatory nucleotide sequences in an expression construct, such as a vector or plasmid. In certain embodiments, such constructs are DNA constructs. Regulatory nucleotide sequences will generally be appropriate for a host cell used for expression. Numerous types of appropriate expression vectors and suitable regulatory sequences are known in the art for a variety of host cells.
[0119] Typically, said one or more regulatory nucleotide sequences may include, but are not limited to, promoter sequences, leader or signal sequences, ribosomal binding sites, transcriptional start and termination sequences, translational start and termination sequences, and enhancer or activator sequences. Constitutive or inducible promoters as known in the art are contemplated by the embodiments of the present disclosure. The promoters may be either naturally occurring promoters, or hybrid promoters that combine elements of more than one promoter.
[0120] An expression construct may be present in a cell on an episome, such as a plasmid, or the expression construct may be inserted in a chromosome. Preferably, the expression vector contains a selectable marker gene to allow the selection of transformed host cells. Selectable marker genes are well known in the art and will vary with the host cell used.
[0121] The present disclosure also provides expression vectors comprising a nucleotide sequence encoding a modified protein of interest that is preferably operably linked to at least one regulatory sequence. Regulatory sequences are art-recognized and are selected to direct expression of the encoded polypeptide.
[0122] Accordingly, the term regulatory sequence includes promoters, enhancers, and other expression control elements. The design of the expression vector may depend on such factors as the choice of the host cell to be transformed and/or the type of protein desired to be expressed.
[0123] The present disclosure also provides a host cell transfected with an mRNA or DNA described herein which encodes a modified polypeptide described herein. For example, the modified polypeptide has the sequence of SEQ ID NO: 4. The host cell may be any prokaryotic or eukaryotic cell. For example, a modified polypeptide described herein may be expressed in bacterial cells such as E. coli, insect cells (e.g., using a baculovirus expression system), yeast, or mammalian cells. Other suitable host cells are known to those skilled in the art.
[0124] The present disclosure also provides a host cell comprising a vector comprising a polynucleotide which encodes an mRNA sequence of any one of SEQ ID NOs: 26-229.
[0125] The present disclosure also provides methods of producing a modified therapeutic human protein of interest. For example, a host cell transfected with an expression vector encoding a modified therapeutic protein of interest can be cultured under appropriate conditions to allow expression of the polypeptide to occur. The polypeptide may be secreted and isolated from a mixture of cells and medium containing the polypeptides. Alternatively, the polypeptides may be retained in the cytoplasm or in a membrane fraction and the cells harvested, lysed and the protein isolated. A cell culture includes host cells, media and other byproducts. Suitable media for cell culture are well known in the art.
[0126] The expressed modified therapeutic proteins described herein can be isolated from cell culture medium, host cells, or both using techniques known in the art for purifying proteins, including ion-exchange chromatography, gel filtration chromatography, ultrafiltration, electrophoresis, and immunoaffinity purification with antibodies specific for particular epitopes of the modified polypeptide.
[0127] Therapeutic Proteins
[0128] The modified protein described herein can be a modified therapeutic protein. Any therapeutic human wild-type protein of interest is suitable for modification as described herein. In some embodiments, the therapeutic protein can be an intracellular antibody. Exemplary therapeutic proteins include, but are not limited to, modified therapeutic proteins of the present disclosure that have the activity of the following human wild-type proteins:
[0129] AIBG; AICF; A2M; A2MLI: A4GNT; AAAS; AACS: AADAC; AAGAB; AAKI; AANAT; AARD; AARS2; AARS; AASDH; AASDHPPT;
[0130] AASS; AATF; AATK; ABAT; ABCAI2; ABCAI3; ABCAI; ABCA2; ABCA3; ABCA5; ABCAB; ABCA7; ABCA9; ABCBII; ABCBI; ABCB4; ABCB5;
[0131] ABCB6; ABCB7; ABCB8; ABCB9; ABCCIO; ABCCII; ABCCI2; ABCCI; ABCC2; ABCC3; ABCC4; ABCC5; ABCC6; ABCC8; ABCC9; ABCDI;
[0132] ABCD2; ABCD3; ABCD4; ABCEI; ABCFI; ABCF2; ABCGI; ABCG2; ABCG4; ABCG5; ABCG8; ABHDI2B; ABHDI2; ABHDIBA; ABHDI7B; ABHD2;
[0133] ABHD5; ABHDB; ABII; ABI2; ABI3BP; ABI3; ABU; ABL2; ABLIMI: ABLIM2; ABO; ABRA; ABR; ABTI; ACAAI; ACAA2; ACACA; ACACB5; ACADIO; ACAD8; ACAD9: ACADL; ACADSB; ACADS; ACADVL; ACAN; ACATI; ACAT2; ACBD3; ACBD4; ACBD5; ACBDB; ACCS; ACD; ACE2;
[0134] ACE; ACER2; ACER3; ACHE; ACINI; ACKRI; ACKR2; ACKR3; ACKR4; ACLY; ACMSD; ACDI: AC02; ACOTI3; ACOTI; ACDT2; ACOT9; ACDXI;
[0135] AC0X2; AC0X3; AC0XL; ACPI; ACP2; ACP5; ACP6; ACPP; ACRBP; ACRC; ACR; ACVI; ACSBGI; ACSBG2; ACSF3; ACSLI; ACSL3; ACSL5;
[0136] ACSLB; ACSMI; ACSM2B; ACS3; ACSSI; ACSS2; ACSS3; ACTAI; ACTA2; ACTB; ACTBL2; ACTCI; ACTGI; ACTG2; ACTLBA; ACTLBB;
[0137] ACTL8; ACTL9; ACTNI; ACTN2; ACTN3; ACTN4; ACTRIA; ACTRIB; ACTR2; ACTR3B; ACTR3; ACTR5; ACTRTI; ACVRIB; ACVRIC; ACVRIO; ACVR2A; ACVR2B; ACVRLI; ACYI; ACY3; ACYP2; ADADI; ADA; ADAMIO; ADAMII; ADAMI2; ADAMI5; ADAMI7; ADAMI9; ADAM20; ADAM2I;
[0138] ADAM22; ADAM23; ADAM28; ADAM29; ADAM2; ADAM33; ADAM7; ADAM8; ADAM9; ADAMDECI: ADAMTSIO; ADAMTSI2; ADAMTSI3;
[0139] ADAMTSI4; ADAMTSI5; ADAMTSIB; ADAMTSI7; ADAMTSI8; ADAMTSI9; ADAMTSI; ADAMTS20; ADAMTS2; ADAMTS3; ADANTS4;
[0140] ADAMTS5; ADAMTSB; ADAMTS7; ADAMTSB; ADAMTS9; ADAMTSLI; ADAMTSL2; ADAMTSL3; ADAMTSL4; ADAMTSL5; ADAPI; ADAP2;
[0141] ADARBI; ADARB2; ADAR; ADAT2; ADAT3; ADCK3; ADCK4; ADCYIO; AOCYI; ADCY2; ADCY3; ADCY5; ADCYB; ADCY7; ADCY8; ADCY9; ADCYAPI; ADCYAPIRI; ADD1; ADD2; ADD3; ADGB; ADGRAI; ADGRA2; ADGRA3; ADGRBI; ADGRB2; ADGRB3; ADGRDI; ADGRD2; ADBREI; ADGREZ; ADGRE5; ADGRF5; ADGRGI; ADGRGZ; ADGRG3; ADGRGB; ADGRG7; ADGRL1; ADGRL3; ADGRVI; AOHIA; ADHIB; ADH4; ADH5;
[0142] ADHB; ADH7; ADHFEI; AOIt; AOIG; ADIPBD; ADIPBRI; ADIPDR2; ADIRF; ADK; ADM2; ADM; ADNP; ADO; ADDRAI; ADORA2A; ADORA2B;
[0143] ADPGK; ADPRH; ADPRHL1; ADPRHL2; ADRAIA; ADRAIB; ADRAID; ADRA2A; ADRA2B; ADRA2C; ADRBI; ADRB2; ADRB3; AORB1; ADRBK2;
[0144] ADRMI; ADSL; ADSS; ADSSLI; ADTRP; AEBP2; AEN; AES; AFAPI; AFAPIL; AFAPIL2; AFFI; AFF2; AFF3; AFF4; AFG3L2; AF; AFP; AGA; AGAPt; AGAP2; AGAP3; AGAP4; AGBLI; AGBL2; AGBL3; AGBL4; AGER; AGFGI; AGFG2; AGGFI; AG; AGMD; AGD2; ABPATI AGPAT2;
[0145] AGPAT3; AGPAT4; AGPAT9; AGPS; AGR2; AGR3; ABRN; AGRP; AGT; AGTPBPI; AGTRI; AGTR2; AGXT2; AGXT; AHCY; AHCYL2; AHII;
[0146] AHNAK; AHR; AHRR; AHSAI; AHSA2; AHSG; AICDA; AIDA; AIR: AIFMI AIFM2; AIFM3; AIGI AIM1: AIM2; AIP1; AIMP2; AIP: AIPLI; AIRE;
[0147] AJAPI; AJUBA; AI; A3; AB; AK7; AK8; AK9; AKAPID; AKAPI2; AKAPI3; AKAPI7A; AKAPI; AKAP2; AKAP3; AKAP4; AKAP5; AKAPB;
[0148] AAP7; AKAPB; AIPI AKIRIN2; ANA; AKRIBID; AKRIBI; ACI: AKRIC2; AKRIC3; AKRIC4; AKRIDI; AKRIE2; AKR7A3; AKTI; AKTISI; ID AKT2; AKT3; AKTIP; ALAD; ALASI; ALAS2; ALB; ALCAM; ALDHIBAI: ALDHI8AI: ALDHIAI ALDHIA2; ALDHIA3; ALDHIBI; ALDHIU; ALDH2;
[0149] ALDH3AI; ALDH3A2; ALDH3BI ALDH4AI; ALDH5AI: ALDHBAI: ALDH7AI: ALDH9AI ALDDA; ALDDB; ALDDC; ALGIOB; ALGIQ; ALGII; ALGI2;
[0150] ALGI3; ALGI; ALGIL; ALG2; ALG3; ALG8; ALG9; ALKBHI; ALKBH2; ALKBH3; ALKBH7; ALKBH8; ALK; ALLC; ALMSI; ALDXI2B; ALDXI2;
[0151] AL0XI5B; ALDXI5; ALDX5AP; AL0X5; ALDXE3; ALPI ALPKI; ALPK2; ALPK3; ALPP; ALPPL2; ALS2CL; ALS2CRI2; ALS2; ALXI; ALX4;
[0152] ALYREF; AMACR; AMBN; AMBP; AMBRAI; AMDI; AMELX; AMELY; AMERI; AMER2; AMER3; AMFR; AMH; AMHR2; AMICAI; AMIGD2; 15 AMMECRI; AMN; AMOT; AMDTLI: AMPD2; AMPD3; AMPH; AMT; AMZI; ANAPCIO; ANAPCII; ANAPCI3; ANAPCI; ANAPC2; ANAPC4; ANAPC5;
[0153] ANAPC7; ANG; ANGPTI; ANGPT2; ANGPT4; ANGPTLI ANGPTL2; ANGPTL4; ANGPTLG; ANKI; ANK2; ANK3; AN FNI ANKFYI: ANKHDI-EIF4EBP3; ANKHD1; ANKH; ANKKt; ANKLEI; ANKLE2; ANKMYI; ANKRDIO; ANKRDII; ANKRDI2; ANKRDI8A; ANKRDI; ANKRD23; ANKRD2B;
[0154] ANKRD28; ANKRD2; ANKRD3DA; ANKRD3BB; ANKRD3B; ANKRD37; ANKRD44; ANKRD45; ANKRD4B; ANK D5D; ANKRD55; ANKRDB;
[0155] ANKRD7; ANKSIA; ANKSIB; ANKS4B; ANKSB; ANLN; ANDID; ANDI; AN02; AN03; AND4; AND5; AN06; AND7; ANP32A; ANP32B; ANP32D; 0 ANPEP; ANTXRI; ANTXR2; ANXAID; ANXAII; ANXAI3; ANXAI ANXA2; ANXA2R; ANXA3; ANXA4; ANXA5; ANXAB; ANXA7; ANXA8; ANXABLI;
[0156] ADAH; AOCI; AOC2; AOC3; ADXI: APIAR; APIBI; APIGI; APIMI; APIM2; APISI; APIS2; APIS3; AP2AI; APZBI; AP2MI; AP2SI; AP3BI; AP3DI;
[0157] AP3M2; AP3SI; AP3S2; AP4BI; AP4EI; AP4MI; AP4SI AP5MI: AP5ZI; APAFI; APBAI; APBA2; APBA3; APBBI; APBBIIP; APBB2; APBB3;
[0158] APC2; APCDDI; APCDDIL; APC; APCS; APEH; APEXI; APEX2; APHIB; APIS; APIP; APLN; APLNR; APLPI; APLP2; APDAIBP; AP0A2; AP0A4;
[0159] APDA5; APDBECI; APDBEC2; APDBEC3AJ; APOBEC3B; APDBEC3C; APDBEC3F; APDBEC3G; APOBEC3H; APDB; APOBR; AP0C5; APDC2; AP0C3; AP0C4; APDD; APDE; APDF; APDH; APDLI: APDL2; APDL3; APOL4; APOLB; APOLDI: APDM; APDD; APOPTI APPBP2;
[0160] APP; APPLI; APPL2; APRT; APTX; AflPID; ADPI; AOP2; ADP3; ADP4; ADP5; ADPB; ADP7; ADP8; ADP9; ARAF; ARAPI; ARAP3; ARC;
[0161] ARCNI; AREG; ARFI; ARF3; ARF4; ARFB; AFGAPI; ARFGAP2; ARFGAP3; ARFGEFI; ARFGEF2; ARFGEF3; AFiPf; ARFRPI: ARB1; ARGLUI;
[0162] ARHGAPID; ARHGAPIIA; ARHGAPIIB; ARHGAPI5; ARHGAPI8; ARHGAPI; ARHGAP2D; ARHGAP2I; ARHGAP22; ARHGAP23; ARHGAP24; ARHGAP25; ARHGAP2B; ARHGAP27; ARHGAP28; ARHGAP30; ARHGAP3I; ARHGAP32; ARHGAP35; ARHGAP42; ARHGAP4; ARHGAP5; D ARHGAPB; ARHGAP9; ARHGDIA; ARHGDIB; ARHGEFIO; ARHGEFIDL; ARHGEFII: ARHGEFI2; ARHGEFI5; ARHGEFIB; ARHGEFI7; ARHGEFI:
[0163] ARHGEF25; ARHGEF2B; ARHGEF28; ARHGEF2; ARHGEF38; ARHGEF3; ARHGEF4; ARHGEF5; ARHGEFB; ARHGEF7; ARHGEF9; AR; ARIDIB;
[0164] ARID2; ARID3A; ARID3B; ARID4A; ARID4B; ARID5B; ARIHI; ARUI; ARLI3A; ARLI3B; ARLI4EP; ARLI4; ARLI5; ARLI; ARL2BP; ARL2; ARL3;
[0165] ARL4A; ARL4C; ARL4D; ARL5A; ARL5B; ARLB; ARLBIPI; ARLBIP5; ARMCIO; ARMCI ARMC2; ARMC3; ARMC4; ARMC5; ARMC8; ARMC9;
[0166] ARMCXI; ARMS2; ARMTI: ARNT2; ARNT; ARNTL2; ARNTL; ARPCIA; ARPCIB; ARPC2; ARPC3; ARPC5; ARPIN; ARPP2I; ARR3; ARRBI; 5 ARRB2; ARRDC2; ARRDC3; ARRDC4; ARSA; ARSB; ARSD; ARSE; ARSF; ARSG; ARSH; ARSI: ARSJ; ARSK; ARTI; ART3; ART4; ARVCF; ARX; AS3MT; ASAHI; ASAH2; ASAPI; ASAP2; ASBID; ASBI3; ASBI5; ASBIS; ASBI; ASB2; ASBB; ASB7; ASCCI; ASCC2; ASCC3; ASCLI;
[0167] ASCL2; ASCL4; ASFIA; ASFIB; ASHIL; ASH2L; ASICI; ASIC2; ASIC3; ASIC4; ASICS; ASIP; ASL; ASMT; ASMTL; ASNAI; ASMS; ASPA; ASPG;
[0168] ASPH; ASPM; ASPN; ASPRVI; ASPSCRI; ASRBLI; ASSI ASTN2; ASUN; ASXLI; ASXL2; ASXL3; ASZI; ATAD2; ATAD3B; ATAD3C; ATAD5;
[0169] ATATI; ATCAY; ATEI; ATFI; ATF2; ATF3; ATF4; ATF5; ATFBB; ATFB; ATF7; ATF7IP; ATBIO; ATGI2; ATGIBLI: ATG2B; ATG3; ATG4A; ATG4B; ATG4C; ATG5; ATG7; ATG9A; ATIC; ATLI; ATL2; ATL3; ATM; ATNI; ATDHI; ATDH7; ATOXI; ATPIDA; ATPIOB; ATPIOD; ATPIIA; ATPIIAUN;
[0170] ATPIIB; ATPI2A; ATPI3A3; ATPI3A4; ATPIA2; ATPIA3; ATPIA4; ATPIBI; ATPIB2; ATP2AI; ATP2A2; ATP2A3; ATP2BI; ATP2B2; ATP2B3; ATP2B4; ATP2CI; ATP2C2; ATP4A; ATP4B; ATP5AI; ATP5B; ATP5CI; ATP5D; ATP5E; ATP5GI; ATP5G2; ATP5G3; ATP5H; ATP5J2; ATP5J;
[0171] ATP5L; ATP5D; ATPBAPI; ATPBAPIL; ATPBAP2; ATP6V0AI; ATPBV0A2; ATPBV0A4; ATPBVOC; ATPBVDDI; ATPBVOEI; ATPGVOE2;
[0172] ATPBVIBI; ATPGVIB2; ATPBVICI; ATPBVIO; ATPBVIEI; ATPBVIF; ATPBVIGI; ATPBVIG2; ATPBVIG3; ATP7A; ATP7B; ATP8AI; ATP8A2; ATP8BI; ATP8B3; ATP8B4; ATP9B; ATPAF2; ATRAID; ATR; ATRIP; ATRN; ATRNLI; ATRX; ATXNIO; ATXNI; ATXNIL; ATXN2; ATXN2L; ATXN 3;
[0173] ATXN7; ATXN7L3B; AUH; AURKA; AU KB; AURKC; AUTS2; AVEN; AVP; AVPII; AVPRIA; AVPRIB; AVPR2; AWATI; AXDNDI; AXINI: AXIN2;
[0174] AXL; AZGPI; AZI2; AZINI; AZIN2; AZUI; B2M; B3GALNTI; B3GALNT2; B3GALT2; B3GALT4; B3GALT5; B3GALTL; B3GATI; B3GAT2; B3GAT3;
[0175] B3GNT2; B3GNT3; B3GNT5; B3GNTB; B3GNT8; B3GNTLI; B4GALNTI; B4GALNT2; B4GALNT3; B4GALTI; B4GALT3; B4GALT4; B4GALT5;
[0176] B4GALTB; B4GALT7; B4GATI; B9DI: B9D2; BAALC; BAAT; BABAMI; BACEI; BACE2; BACHI; BACH2; BAD; BAG); BAG3; BAG4; BAGS; BAGB; BAIAP2LI; BAIAP3; BAKU BAMBI: BANFI BANKI; BANP; BAPI; BARDI; BARHLI; BARXI: BARX2; BASPI; BATF2; BATF; BAX; BAZIA; BAZIB;
[0177] BAZ2A; BAZ2B; BBC3; BBIPI; BBOXI; BBSID; BBSI2; BBS1; BBS2; BBS4; BBSS; BBS7; BBSS; BBX; BCAM; BCAN; BCAP29; BCAP3I;
[0178] BCARI; BCASI; BCAS3; BCAS4; BCATI; BCAT2; BCCIP; BCDIN3D; BCHE; BC DHA; BC DHB; BC DK; BCLIO; BCLIIA; BCLIIB; BCL2AI;
[0179] BCL2; BCL2LIO; BCL2LII; BCL2LI2; BCL2LI3; BCL2LI4; BCL2LI; BCL2L2; BCL2L2-PABPNI; BCL3; BCLBB; BCLB; BCL7A; BCL7B; BCL7C;
[0180] BCL9L; BCLAFI; BCDI; BC02; BCDR; BCORLI; BCR; BCSIL; BDHI; BDH2; BDKRBI; BDKRB2; BDNF; BDPI; BEANI: BEGAIN; BENDS; BEND4; BESTI; BEST2; BETI; BETIL; BEXI; BEX2; BEX4; BFAR; BFSPI; BFSP2; BGLAP; BGN; BHLHAI5; BHLHA9; BHLHB9; BHLHE22; BHLHE23;
[0181] BHLHE40; BHLHE4I; BHMT2; BHMT; BICCI; BICDI; BICD2; BID; BINI: BIN2; BINS; BIRC2; BIRC3; BIRC5; BIRCB; BIRC7; BIVM; BLCAP;
[0182] BUD; BLK; BLMH; BLM; BLNK; BLOCIS2; BLDCIS3; BLOCIS4; BLOCIS5; BLDCISB; BLVRA; BLVRB; BLZFI: BMF; BMII BMPIO; BMPI5;
[0183] BMPI; BMP2; BMP2K; BMP3; BMP4; BMP5; BMPG: BMP7; BMP8B; BMPER; BMPRIA; BMPRIB; BMPR2; BMSI; BMX; BNCI; BNC2; BNIPI;
[0184] BNIP2; BNIP3; BNIP3L; BNIPL; BDC; BODIL2; BO; BOLA3; BDLL; BDPI: BORA; BPGM; BPIFAI; BPIFA2; BPIFA3; BPIFBI BPIFB2; BPIFC; BPI; BPNTI; BPTF; BPY2; BRAF; BRAP; BRATI; BRCAI; BRCA2: BRCC3; BRDI; BRD2; BRD3; BRD4; BRD7; BRD8; BRE; BRFI; BRF2;
[0185] BRI3BP; BRI3; BRINPI; BRINP2; BRINP3; BRIPI; BRKI; BRMSI; BRMSIL; BRS3; BRSI; BRSK2; BRWDI: BRWD3; BSCL2; BSG; BSN;
[0186] BSPHI; BSPRY; BSTI; BST2; BSX; BTBDID; BTBDII; BTBDIB; BTBDI; BTBD2; BTBD3; BTBD9; BTC; BTD; BTF3; BTGI; BTG2; BTG3; BTG4;
[0187] BTK; BTLA; BTNIAI; BTN2AI; BTN2A2; BTN3AI; BTN3A2; BTN3A3; BTNL2; BTRC; BUBIB; BUBI; BUB3; BUDI3; BUD3I; BVES; BYSL;
[0188] BZRAPI; BZWI; CID; CIGALTICI; CIGALTI;
[0189] CIOB; CIDBP; CIQLI; CIDL3; CIQTNFI; CIQTNF3; C1QTNF5: CIOTNFB; CIOTNF7; CIDTNF9B-ASI; CIR: CIRL; CIS; C2CO3; C2CD4A; C2CD4B; C2CD5; C2; C4A; C4B2; C4B; C4BPA; C4BPB; C5ARI:
[0190] C5AR2; C5; CB;
[0191] CAIO; CAM; CAI2; CAI3; CAI; CA2; CA3; CA4; CA5A; CAB; CA8; CAB39; CAB39L; CABINI; CABLES!; CABP2; CABP4; CABSI;
[0192] CABYR; CACNAIA; CACNAIB; CACNAIC; CACNAID; CACNAIE; CACNAiF: CACNAIG; CACNAIH; CACNAII: CACNAIS; CACNA2DI; CACNA2D2;
[0193] CACNA2D3; CACNA2D4; CACNBI; CACNB2; CACNB3; CACNB4; CACNG2; CACNG3; GACNG4; CACNG5; CACNGB; CACULI; CACYBP; CAD; ID CADMI; CADM2; CADM3; CADM4; CADPS2; CADPS; GAGEI; CALBI; CALB2; CALCA; CALCB; CALCOCDI; CALCDCD2; CALCR; CALCRL;
[0194] CALDI; CALHMI; CALHM2; CALHM3; CALM2; CALML3; CALML5; CALNI: CALR3; CALR; CALU; CALY; CAMKID; CAMKIG; CAMKI; CAMK2A;
[0195] CAMK2B; CAMK2D; CAMK2G; CAMK4; CAM KI: CAMKK2; CAMKMT; CAMLG; CAMP; CAMSAPI; CAMSAP2; CA TAI; CANOI: CAND2; CANTI:
[0196] CANX; CAPI; CAP2; CAPG; CAPNID; CAPNI3; CAPNI4; CAPNI CAPN2; CAPN3; CAPN5; CAPNB; CAPN7; CAPN9; CAPNSI: CAPRINI;
[0197] CAPRIN2; CAPS2; CAPS; CAPSL; CAPZA2; CAPZA3; CARDID; CARDII; CARDI4; CARDIB; CARDB; CARDS: CARD9; CARF; CARKD; CARMI; 15 CARS; CARTPT; CASCI; CASC3; CASC4; CASC5; CASDI; CASK; CASPIO; CASPI4; CASPI; CASP2; CASP3; CASP4; CASP5; CASPB;
[0198] CASP7; CASP8AP2; CASPB; CASPB; CASDI CASR; CASS4; CAST: CASZI: CAT; CATSPERI; CATSPER2; CAVI; CAV2; CAV3; CBFA2T2;
[0199] CBFA2T3; CBFB; CBLB; CBL; CBLLI; CBLNI; CBLN2; CBLN4; CBRI; CBR3; CBR4; CBS; CBXI; CBX2; CBX3; CBX4; CBX5; CBXB; CBX7;
[0200] CBX8; CBYI; CC2DIA; CC2DIB; CC2D2A; CCARI; CCAR2; CCBEI; CCBLI; CCDCIDI; CCDCI02B; CCDCID3; CCDCID5; CCDCID8; CCDCII4;
[0201] CCDCII5; CCDCI2I; CCDCI22; CCDCI29; CCDCI3D; CCDCI34; CCDCI3B; CCDCI40; CCDCI4I; CCDCI48; CCDCI5I; CCDCIB7; CCDCIB9-D SOHLH2; CCDCI70; CCDCI7I; CCDCI75; CCDCI7B; CCDCI78; CCDCI8D; CCDCI8I: CCDCI85; CCDCI22; CCDCI28A; CCDCI39; CCDCI3;
[0202] CCDCI4D; CCDCI42B; CCDCI42; CCDCI5D; CCDCI54; CCDCBD; CCDCB2; CCDCB3; CCDCG5; CCDCBB; CCDCB7; CCDCB8; CCDCB;
[0203] CCDCI78; CCDCI8D; CCDCI83; CCDCI85A; CCDCBB; CCDCI88A; CCDCI88C; CCDCI8; CCDCI9I; CCDCI94; CCDCI97; CCHCRI; CCKAR; CCKBR;
[0204] CCK; CGLII; CCLI3; CCLI4; CCLI5; CCLIB; CCLI7; CCLI8; CCLI9; CCD; CCL2D; CCLZI: CCL22; CCL23; CCL24; CCL25; CCL2G; CCL27;
[0205] CCL28; CCL2; CCL3; CCL3L3; CCL4; CCL4LI; CCL4L2; CCL5; CCL7; CCL8; CCM2; CCNAI; CCNA2; CCNBI; CCNB2; CCNB3; CCNC; CCNDt:5 CCND2; CCND3; CCNDBPI: CCNEI; CCNE2; CCNF; CCNBI: CCNG2; CCNH; CCNI; CCNJ; CCNJL; CCNK; CCNL1; CCNL2; CCNO; CCNTI;
[0206] CCNY; CCPIID; CCRID; CCRI; CCR2; CCR3; CGR4; CCR5; CCRB; CCR7; CCR8; CCR9; CCRL2; CCRN4L; CCSERI; CCS; CCT2; CCT3; CCT4;
[0207] CCT5; CCTGA; CCTBB; CCT7; CDI09; CDI4; CDI5I; CDIB3; CDIB3LI; CDIB4; CDI77; CDI8D; CDI9; CDIA; CDIB; CDIC; CDID; CDIE; CD20D;
[0208] CD2DDRI; CD2D7; CD2D9; CD22B; CD22; CD244; CD247; CD248; CD24; CD274; CD27B; CD27; CD28; CD2AP; CD3DDA; CD3DOC;
[0209] CD3D0LF; CD302; CD320; CD33; CD34; CD3B; CD37; CD38; CD3D; CD3EAP; CD3E; CD3G; CD40; CD4DLG; CD44; CD4B; CD47; CD48; D CD4; CD55; CD59; CD5; CD5L; CDB3; CDG8; CDB9: CDB; CD72; CD74; CD79A; CD79B; CD7; CD8D; CD8I; CD82; CD83; CD84; CD8B;
[0210] CD8A; CD8B; CD93; CD9B; CD99; CDB; CDADCI: CDANI; CDCI23; CDCI4A; CDCI4B; CDCIG; CDCI2DB; CDCI23; CDCI25A; CDCI25B;
[0211] CDCI25C; CDCI27; CDCI34; CDCI37; CDCI37LI; CDCI42BPA; CDCI42BPB; CDCI42BPG; CDCI4ZEPI: CDCI42EP3; CDCI42SE2; CDCI45; CDCI5L;
[0212] CDCB; CDCI73; CDCI7; CDCA2; CDCA3; CDCA5; CDCA7; CDCA7L; CDCPI; CDHID; CDH11: CDHI3; CDHI5; CDHIB; CDHI7; CDHI8; CDHI9;
[0213] CDHI; CDH2D; CDH22; CDH23; CDH2B; CDH2; CDH3; CDH4; CDH5; CDHB; CDH7; CDH8; CDH9; CDHRI; CDHR2; CDHR3; CDHR5; CDIPT; 5 CDKID; CDKIIB; CDKI2; CDKI3; CDKI4; CDKI5; CDKIB; CDKI7; CDKI8; CDKI9; CDKI; CDK2D; CDK2API; CDK2AP2; CDK2; CDK3; CDK4; C0K5; CDK5 I: CDK5R2; CDK5RAPI: CDK5RAP2; CDK5 AP3; CDKB; CDK7; CDK8; CDK9; CDKALI; CDKLI CDKL2; C0KL3; CDKL4;
[0214] CDKL5; CDKNIA; CDKNIB; CDKNIC; CDKN2A; C0KN2A1P: CDKN2B; CDKN2C; CDKN2D; CDKN3; CDNF; COOI; CDON; CDRI; CDR2; CDS2;
[0215] CDTI: CDV3; CDXI CDX2; CDX4; GDYIB; CDY2B; CDYL2; CDYL; CEACAMIB; CEACAMIB; CEACAMI; CEACAM2I; CEACAM3; CEACAM4;
[0216] CEACAM5; CEACAMB; CEACAM7; CEACAM8; CEBPA; CEBPB; CEBPD; CEBPE; CEBPG; CEBPZ; CECRI; CECR2; CELAI: CELA3B; CELFI; CELF2; CELF4; CELF5; CELFB; GEL; CELSRI; CELSR3; CEMIP; CEMPI; CENDI; CENPA; CENPB; CENPC; CENPE; CENPF; CENPH; CENPJ;
[0217] CENPK; CENPN; CENPO; CENPO; CENPU; CENPV; CENPW; CEPII2; CEPI2D; CEPI28; CEPI3I; CEPI35; CEPI52; CEPIB2; CEPIB4; CEPI7D;
[0218] CEPI92; CEPIB; CEP25D; CEP29D; CEP4I; CEP55; CEP57; CEPB3; CEPG8; CEP72; CEP7B; CEP83; CEP85L; CEP83; CERI; CERK; CERKL;
[0219] CERSI; CERS2; CERS3; CERS4; CERSB; CESh CES2; CES3; CETNI; CETN2; CETN3; CETP; CFAPI2B; CFAP3B; CFAP44; CFAP52; CFAP53;
[0220] CFAP57; CFAP58; CFAPBI; CFAPBB; CFAP97; CFB; CFCIB; CFCI; CFD; CFDPI; CFH; CFHRI; CFHR2; CFHR3; CFHR4; CFH 5; CFI; CFLI; CFL2; CFLAR; CFP; CFTR; CGA; CGBI; CGB2; CGB5; CGB7; CBN; CGNLI; CGRRFI: CH25H; CHACI; CHAD; CHAFIA; CHAFIB; CHAMPI CHAT;
[0221] CHCHDIO; CHCHDI; CHCHD3; CHCHD5; CHCHDB; CHCHD7; CHDI; CHD2; CHD3; CHD4; CHDB; CHD7; CHD8: CHDH; CHEKI; CHEK2;
[0222] CHERP; CHFR; CHGA; CHGB; CHI3LI; CHICI; CHIC2; CHITI; CHKA; CHKB; CHLI; CHM; CHML; CHMPIA; CHMPIB; CHMP2B; CHMP3;
[0223] CHMP4A; CHMP4B; CHMP4C; CHMP5; CHMI: CHN2; CHDDL; CHORDCI; CHPI: CHP2; CHPF; CHPTI CHRACI; CHRD; CHRDLI: CHRFAM7A;
[0224] CHRMI; CHRM2; CHRM3; CHRM4; CHRM5; CHRNAIO; CHRNAI; CHRNA2; CHRNA3; CHRNA4; CHRNA5; CHRNAB; CH NA7; CHRNBI; CHRNB2; CHRNB3; CHRNB4; CHRND; CHRNE; CHRNG; CHSTIO; CHSTII; CHSTI2; CHSTI3; CHSTI4; CHSTI5; CHSTI; CHST2; CHST3;
[0225] CHST4; CHST5; CHSTB; CHST8; CHST9; CHSYI; CHSY3; CHTFI8; CHTOP; CHURCI; CIADI; CIAPINI; CIBI; CIB2; CIC; CIDEB; CIDEC; CIITA;
[0226] CILP2; CILP; CINP; CIPC; GIRL CIRBP; CIRHIA; CISDI; CISD2; CISH; CITEDI; CITED2; CIT; CIZI: CKAP2; CKAP2L; CKAP4; CKAP5; CKB;
[0227] CKLF; CKM; CKMTIA; CKMTIB; CKMT2; CKSIB; CKS2; CLASPI; CLASP2; CLCA2; CLCA4; CLCFI; CLC; CLCNI; CLCN2; CLCN3; CLGN4;
[0228] CLCN5; CLCNB; CLCN7; CLCNKB; CLDNID; CLDNII; CLDNI4; CLDNI5; CLDNIB; CLDNI8; CLDNI; CLDN23; CLDN2; CLDN5; CLDNB; CLDN7; CLDN8; CLDNB; CLECIDA; CLECIIA; CLECI2A; CLECI4A; CLECIBA; CLECIB; CLEC2A; CLEC2B; CLEC2D; CLEC2L; CLEC3B; CLEC4A;
[0229] CLEC4C; CLEC4D; CLEC4E; CLEC4G; CLEC4M; CLEC5A; CLECBA; CLEC7A; CLEC9A; CLECLI; CLGN; CLICI; CLIC3; CLIC5; CLICB; CLINTI;
[0230] CLIP1; CLIP2; CLKl; CLK2; CLLUI; CLMN; CLMP; CLN3; CLN5; CLNB; CLNB: CLNK; CLNSIA; CLOCK; CLPI; CLPP; CLPS; CLPTMI; CLPTMIL;
[0231] CLRNI; CLSPN; CLSTNI; CLSTN2; CLTA; CLTC; CLTCLI: CLUAPI; CLU; CLULI; CLVSI: CLYBL; CMAI; DMAS; CMCI; CMC2; CMC4; CMIP;
[0232] CMKLRI; CMPK2; CMSSI; CMTM3; CMTM5; CMTM7; CMTM8; CMTRI; CMTR2; CMYA5; CNBDI; CNBP; CNDPI; CNDP2; CNGAI; CNGA3; CNGBI; CNGB3; CNIH3; CNKSRI; CNKSR2; CNKSR3; CNNI; CNN2; CNNMI: CNNM2; CNNM4; CNQTI; CNBT2; CNDT3; CN0T4; CNDTB;
[0233] CNOTGL; CN0T7; CN0T8; CNP; CNPY2; CNPY3; CNRI: CNR2; CNRIPI: CNST; CNTF; CNTFR; CNTLN; CNTNI; CNTN2; CNTN3; CNTN4;
[0234] CNTN5; CNTNB; CNTNAPI; CNTNAP2; CNTNAP3; CNTNAP4; CNTNAP5; CNTRL; CNTROB; COAI; COA5; CDASY; COBL; COBLLI; COCH;
[0235] COGI; COG2; COG3; COG4; COG5; COGB; COG7; COG8; COIL; COLIDAI; COLIIAI; COLIIA2; COLI2AI; COLI3AI; COLI4AI; COLI5AI; COLIBAI;
[0236] COLI7AI; COLI8AI; COLIAI; COLIA2; COL2OAI; COL2IAI; COL22AI; COL23AI: COL24AI; COL25AI; COL2BAI; COL27AI; COL28AI; COL2AI; COL3AI; COL4AI; COL4A2; COL4A3BP; COL4A3; COL4A4; COL4A5; COL4AB; COL5AI; COL5A2; COL5A3; COLGAI; COLBA2; COLBA3;
[0237] COLBA5; COL7AI; COL8AI; COL8A2; COLGAI; COL9A2; COL9A3; COLCAI; COLCA2; COLECIO; COLECII: COLECI2; COLGALT2; COLQ;
[0238] COMMDIO; COMMDI; COMMD3-BMII; COMMD5; COMMD7; COMP; COMT; COPA; COPBI; COPB2; COPE; COPG2; COPRS; COPS2; COPS3;
[0239] COPS4; COPS5; COPSE; COPS7A; COPS8; COPZ2; COD2; COO3; COO4; COO5; COO6; COO7; COO9; CORIN; CORDIA; CORDIB; COROIC;
[0240] CORO2A; CORO2B; COROB; CORO7; CORO7-PAMIG; COTLI; COXIO; COXII; COXI4; COXI5; COMB; COXI7; COXI8; COX19; COX4II; COX4I2; COX5A; COX5B; COXBAI; COXBA2; COXBBI; COXGC; COX7AI; COX7A2; COX7A2L; COX7B2; COX7B; COX7C; COX8A; CPA1; CPA2; CPA3; CPA4; CPAB; CPAMD8; CPBI; CPB2; CPD; CPEBI; CPEB3; CPEB4; CPEOI; CPE; CP; CPLXI; CPLX2; CPLX3; CPLX4; CPM; CPNI; CPN2;
[0241] CPNEI; CPNE2; CPNE3: CPNE4; CPNE7; CPNE8: CPD; CPDX: CPPEOI; CPD; CPSI; CPSFI; CPSF2; CPSF3; CPSF3L; CPSF4; CPSFB;
[0242] CPSF7; CPTIA; CPTIB; CPTIC; CPVL; CPXCRI; CPZ; CRI; CR2; CRABPI; CRABP2; CRACR2A; CRADD; CRAMPIL; CRAT; C BI; CRB2; CRB3;
[0243] CRBN; CRCP; CRCTI; CREBI; CREB3; CREB3LI; CREB3L2; CREB3L3; CREB3L4; CREB5; CREBBP; CREBRF; CREBZF; CREGI; CRELDI; CRELD2; CREM; CRHBP; CRH; CRHRI: CRHR2; CRIMI; CRIP2; CRIP3; CRIPAK; CRIPT; CRISPI; CRISP2; CRISP3; CRISPLDI; CRISPLD2;
[0244] CRK; CRKL; CRLFI; CRLF2: CRLF3; CRLSI; CRMPI; CRNKLI: CRNN; CRDCC; CROT; CRP; CRTACI: CRTAM; CRTAP; CRTCI; CRTC2; CRTC3;
[0245] CRX; CRYI; CRY2; CRYAB; CRYBAI; CRYBA2; CRYBA4; CRYBBI; CRYBB2; CRYBB3; CRYGB; CRYGC; CRYGD; CRYGS; CRYLI CRYM;
[0246] CRYZLI; CSAD; CSAG3; CSEIL; CSFIR; CSF2; CSF2RA; CSF2RB; CSF3; CSGALNACTI; CSGALNACT2; CSHI; CSH2; CSHLI; CS; CSK;
[0247] CSMDI; CSMD2; CSMD3; CSNISI; CSN2; CSN3; CSNKIAI CSNKID; CSNKIG3; CSNK2AI CSNK2A2; CSNK2B; CSPG4; CSPG5; CSPPI; CSRNPI; CSRNP3; CSRPI CSRP2BP; CSRP2; CSRP3; CSTI; CST2; CST3; CST4; CST5; CSTB; CST7; CST8; CST9; CSTBL; CSTA; CSTB;
[0248] CSTFI; CSTF2; CSTF2T: CSTLI: CT45AI; CT55; CT83: CTAGIA; CTAG2; CTAGEI; CTAGE5; CTBPI; CTBP2; CTCI; CTCF; CTCFL; CTDP1:
[0249] CTDSPI; CTDSP2; CTDSPL; CTFI; CTGF; CTHRCI; CTIF; CTLA4; CTNNAI; CTNNA2; CTNNA3; CTNNALI; CTNNBt; CTNNBLI: CTNNDI;
[0250] CTNND2; CTNS; CTPSI; CTR9; CTRBI; CTRB2; CTRC; CTRL; CTSA; CTSB; CTSC; CTSD; CTSE; CTSF; CTSG; CTSH; CTSL; CTSD; CTSV;
[0251] CTSW; CTSZ; CTTNBP2; CTTN; CTUI; CTXN3; CUBN; CUEDCI; CUEDC2; CULL: CUL2; CUL3; CUL4A; CUL4B; CUL5; CUL7; CUL9; CUTA; CUXI; CUX2; CUZDI; CWC22; CWC27; CWFIBLI; CWFIBL2; CWH43; CX3CLI; CX3CRI; CXADR; CXCLIO; CXCLII: CXC LIZ; CXCLI3; CXCLI4;
[0252] CXCLIB; CXCLI7; CXCLI; CXCL2; CXCL3; CXCL5; CXCLB; CXCL8; CXCL9; CXCRI; CXCR2; CXCR3; CXCR4; CXCR5; CXCRB;
[0253] CXXCI; CXXC4; CYB5BID2; CYB5BI; CYB5A; CYB5B; CYB5R3; CYB5R4; CYBA; CYBB; CYBRDI: CYCI; CYCS; CYFIPI;
[0254] CYFIP2; CYGB; CYLCI; CYLC2; CYLD; CYP11A1; CYPIIBI: CYPIIB2; CYPI7AI; CYPI9AI; CYP1A1: CYPIA2; CYPIBI; CYP2IA2; CYP24AI;
[0255] CYP2BAI; CYP2BBI; CYP2GCI; CYP27AI; CYP27BI; CYP27CI: CYP2AI3; CYP2AB; CYP2A7; CYP2BB; CYP2CI8; CYP2CI9; CYP2C8; CYP2C9; CYP2DG; CYP2EI; CYP2FI; CYP2RI; CYP2SI; CYP2UI; CYP2WI; CYP39AI; CYP3A43; CYP3A4: CYP3A5; CYP3A7-CYP3A5IP;
[0256] CYP3A7; CYP4BAI; CYP4AII; CYP4BI; CYP4FII; CYP4FI2; CYP4F22; CYP4F2; CYP4F3; CYP4F8; CYP4V2; CYP5IAI; CYP7AI; CYP7BI;
[0257] CYP8BI; CYSI; CYSLTRI; CYTHI; CYTH3; CYTIP; CYTLI; CYYRI; D2HGDH; DAAMI: DAAM2; DAB2; DAB2IP; DACHI; DACH2; DACTI; DACT2;
[0258] DACT3; DADI: DAGI; DAND5; OAOA: DAD; DAPS; DAP; DAPKI: DAPK2; DAPK3; DARS2; DARS; DAWi DAXX; DAZI; DAZ2; DAZ3; DAZ4;
[0259] DAZAP1; DAZAP2; DAZL; DBF4; DBH; DBI; DBNI; DBNL; DBP; DBRI; DBXI; DCAFI2; DCAFI3; DCAFI7; DCAF4; DCAF5; DCAFB; DCAF7; DCAF8; DCANPI; DCBLDI: DCBLD2; DCC; DCDCI2C; DCDCI2; DCD; DCHSI; DCHS2; DCK; DCLKI; DCLK2; DCLK3; DCLREIA; DCLREIC; DCN;
[0260] DCPIA; DCPIB; DCPS; DCSTI; DCST2; DCSTAMP; DCTD; DCT; DCTNI; DCTN2; DCTN3; DCTN4; DCTN5; DCTNB; DCUNIDI OCX; DCXR;
[0261] DDAHI; DDAH2; DDBI DDB2; DDC; DDHDI; DDHD2; DON: DDIAS; DDIT3; DDIT4; DDIT4L; DON; ODD: DDRI; DDR2; DDRGKI; DDT; DDTL;
[0262] DDXIO; DDXII; DDXI7; DDXI8; DDXIBA; DDXI; DDX2I; DDX25; DDX27; DDX28; DDX31; DDX39A; DDX39B; DDX3X; DDX3Y; DDX4I; DDX42; DDX43; DDX4G; DDX4; DDX5D; DDX5I; DDX52; DDX53; DDX54; DDX5B; 00X58; DDX59; DOX5; DDXBD; DOX6; DEAR; DECI: DECRI; DEDD; DEFG; DEFAIB; DEFA3; DEFA4; DEFA5; DEFAG; DEFB103B; DEFBIO4B; DEFBI05A; DEFBIOBA; DEFBI08B; DEFBII2; DEFBI25;
[0263] DEFBI2G; DEFBI; DEFB4A; DEBSI; DEGS2; DEK: DENNDIA; DENNDIB; DENND2A; DENND4A; DENR; DEPDCIB; DEPDC5; DEPTDR; DERA;
[0264] OERLI; DERL2; DERL3; DES; DESI2; DEXI; DFFB; DFNA5; DFNB3I: OFNB59; DGATI; DGAT2; DGCR2; DGCRBL; DGCR8; DGKA; DGKB;
[0265] DGKD; DGKE; DGKG; DGKH; DGKI; DGKK; DGKfl; DGKZ; DGUOK; DHCR7; DHDH; DHFR; DHFRLI; DHH; DHDDH; DHPS; DHRSII; DHRS2;
[0266] DHRS4; DHRS7C; DHRS9; DHTKDI; DHXI5; DHXIB; DHX32; DHX34; DHX3B; DHX38; DHX4D; DHX58; DHX8; DHX9; DIABLO; DIAPHI; DIAPH2; DIAPH3; DICERI; DIDOI; DIEXF; DIP2A; DIP2B; DIP2C; DIRASI; DIRAS2; DIRCI; DIRC2; DIS3; DIS3L2; DIS3L; DISCI; DISPI OIXOCI; DKCI DKKI: DKK2; DKK3; DKK4; DKKLI; DLAT; DLCI; DLO; DLEC1; DLEU7; DLGI; DLB2; DLG3; DLG4; DLG5; DLGAPI; DLGAP2;
[0267] DLGAP3; DLGAP5; DLKI; DLL1; DLLS; DLL4; DLST; DLXI: DLX2; DLX3; DLX4; DLX5; OLXG; DMBTI; DMCI; DMD; DMGDH; DMKN; DMPI:
[0268] DMPK; DM TI: DMRT2; DMRT3; DMRTAI; DMTFf; DMTN; DMWD; DMXLI: DMXL2; DNA2; ONAAFI; DNAAF2; DNAAF3; DNAAF5; DNAHII;
[0269] DNAHI2; DNAHI7; DNAHI; DNAH2; DNAH3; DNAH5; ONAHB; DNAH7; DNAH8; DNAH9; DNAII; DNAI2; DNAJAI DNAJA2; DNAJA3; DNAJBM: DNAJBI3; DNAJBI; DNAJB2; DNAJB5; DNAJBB; DNAJB7; DNAJB8; DNAJB9; DNAJCIO; DNAJC12; DNAJGI3; DNAJCI4; DNAJCI5;
[0270] DNAJC18; DNAJCI9; ONAJCI; DNAJC27; DNAJC28; DNAJC2; DNAJC3; DNAJC5; DNAJC7; DNALI; DNASEI; DNASEIL2; DNASEIL3; DNASE2B; DNASE2; DNDI; DNER; DNHDI; DNLZ; DNMI: DNMIL; DNM2; DNM3; DNMBP; DNMTI; DNMT3A; DNMT3B; DNMT3L; DNPEP;
[0271] DNTT; DDC2A; DDC2B; DOCKIO; DDCKII DDCKI; DDCK2; DOCKS; D0CK4; DDCK5; DOCKS; DDCK7; DDCK8; DDCKFJ; DDHH; DDKI; DOK2;
[0272] DDK3; DOK4; DDKS; DDKB; DDK7; DDLK; DDNSDN; DDPEY2; DDTIL; DPABTI: DPCD; DPCRI: DPEPI; DPEP2; DPEP3; DPF1; DPF3; DPHI; DPH3; DPHB; DPH7; DPMI; DPM2; DPM3; DPPID; DPP3; DPP4; DPPG; DPP7; DPP8; DPPB; DPPA2; DPPA3; DPPA4; DPT; DPYI9L2;
[0273] DPYI9L3; DPY30; DPYS; DPYSL2; DPYSL3; DPYSL4; DPYSL5; DRAMI; DRAPI; ORCI; DRDI; DRD2; DRD3; DRD4; DR05; DRGI; DRGX;
[0274] DRDSHA: DRP2; OSCI; DSC2; DSC3; DSCAM; DSCAMLI; DSCCI: DSCR4; DSE; DSEL; DSGI; DSG2; DSG3; DSG4; DSP; DSPP; DST; DSTN;
[0275] DSTYK; DTDI; DTHDI DTL; DTNA; DTNB; DTNBPI; DTXI DTX2; DTX3; DTX4; DTYMK; DUOXI; DUOX2; OUDXAI; DOOXA2; DUPDI; DUS2;
[0276] DUSPIO; DUSPII; DUSPI2; DUSPI3; DUSPI4; DUSPI5; DOSPIB; DUSPI8; DUSPI; DUSP2I; DUSP22; DUSP23; DUSP27; DUSP28; DUSP2; DUSP3; DUSP4; DUSP5; DOSPB; DUSP7; DOSP8; DUSP9; OUT; DUX4; DVL2; DVL3; DXO; DYM; DYNAP; DYNCIHI; DYNC1I1: DYNCII2;
[0277] DYNCILII; DYNCZHI: DYNLLI; DYNLL2; DYNLRBI; DYNLTI; DYNLT3; DYRKIA; DYRKIB; DYRK2; DYRK3; DYSF; DYXICI: DZIPI; EZFI; E2F3;
[0278] E2F4; E2F5; E2FB; E2F7; E2F8; E4FI; EAR; EAF2; EARS2; EBAG9; EBFI: EBF2; EBF3; EBF4; EBI3; EBP; EBPL; ECD; ECE2; ECELI; ECHDCl:
[0279] ECHDC3; ECHSI; ECU; ECI2; ECSCR; ECSIT; ECT2; EDA2R; EDA; EDARADD; EDAR; EDC4; EDEMI; EDIL3; EDNI; EDN3; EDNRA; EDNRB;
[0280] EEAI; EED; EEFIAI; EEFIA2; EEFIB2; EEFID; EEFIEI; EEFIG; EEF2; EEFSEC; EFCABII; EFCABI; EFEMPI; EFEMP2; EFHB; EFHCI; EFHC2; EFHOI; EFNAI; EFNA2; EFNA3; EFNA4; EFNA5; EFNBI; EFNB2; EFNB3; EFR3A; EFR3B; EFS; EFTUDI; EFTUD2; EGF; EGFLB; EGFL7; EGFL8; EGFLAM;
[0281] EGFR; EGLNI; EGLN2; EGLN3; EGRI; EGR2; EGR3; EGR4; EHBPI: EHDI; EHD2; EHD3; EHD4; EHF; EHHADH; EHMTI; EHMT2; E124; EIDI
[0282] EIFIAD; EIFIAX; EIFIAY; EIFI; EIF2A; EIF2AKI: EIF2AK2; EIF2AK3; EIF2AK4; EIFZBI: EIF2B2; EIF2B3; EIF2B4; EIF2B5; EIFZSI; EIF2S2;
[0283] EIF2S3; EIF3A; EIF3B; EIF3C; EIF3E; EIF3F; EIF3H; EIF3J; EIF3K; EIF3M; EIF4AI; EIF4A2; EIF4A3; EIF4B; EIF4E2; EIF4E3; EIF4EBPI;
[0284] EIF4EBP2; EIF4EBP3; EIF4E; EIF4ENIFI: EIF4GI; EIF4G2; EIF4H; EIF5A2; EIF5A; EIF5; EIFB; ELACI; ELAC2; ELANE; ELAVLI; ELAVL2; ELAVL3; ELAVL4; ELFI; ELF2; ELF3; ELF4; ELF5; ELKI; ELK3; ELK4; ELL2; ELL; EL DI; ELMO2; ELMODI; ELMOD2; ELMOD3; ELSANI; ELN;
[0285] ELOFI; ELOVL2; ELOVL4; ELOVL5; ELOVLB; ELOVL7; ELP2; ELP3; ELP4; ELPB; ELSPBPI; EMB; EMCIO; EMC2; EMC3; EMC7; EMC8; EMCN;
[0286] EMD; EMEI; EMGI; EMILINI; EMILIN2; EMILIN3; EMU; EML2; EML4; EML5; EMLB; EMPI: EMP2; EMXI; EMX2; ENI; EN2; ENAH: ENAM; ENCI;
[0287] ENDDG; ENDDU; ENDDV; ENGASE; ENG; ENHO; ENO2; ENO3; ENO4; ENBPHI: ENOSFI: ENDXI: ENOX2; ENPEP; ENPPI; ENPP2; ENPP3;
[0288] ENPP5; ENPP7; ENTHD2; ENTPDI; ENTPD2; ENTPD4; ENTPD5; ENTPDB; ENTPD7; EOGT; EOMES; EP300; EP400; EPASI; EPB4ILI: EPB4IL2; EPB4IL3; EPB4IL4A; EPB4IL4B; EPB42; EPCI: EPC2; EPCAM; EPDRI; EPG5; EPGN; EPHAI: EPHA3; EPHA4; EPHA5; EPHAB;
[0289] EPHA7; EPHBI; EPHB3; EPHB4; EPHBB; EPHXI; EPHX2; EPHX3; EPM2A; EPM2AIPI; EPNI; EPO; EPOR; EPPIN; EPPIN-WFDCB; EPP I:
[0290] EPRS; EPSI5LI; EPS8; EPS8L2; EPSTi1: EPX; EPYC; ERALI; ERAPI; ERAP2; ERAS; ERBB2; ERBB2IP; ERBB3; ERBB4; ERCI; ERC2; ERCCI;
[0291] ERCC2; ERCC3; ERCC4; ERCC5; ERCCB; ERCCBL2; ERCCB-PGBD3; ERCC8; EREG; ERF; ERG; ERGICI; ERGIC2; ERGIC3; ERI3; ERICH5;
[0292] ERICHBB; ERLECI; ERLINI; ERLIN2; ERMAP; ERMARD; ERMPI; ERNI; ERN2; EROILB; ERDIL; ERP29; ERP44; ERV3-I: ERVW-I; ESAM; ESCOI; ESC02; ESD; ESFI; ESMI; ESPLI; ESPN; ESRI; ESR2; ESRPI; ESRP2; ESRRA; ESRRB; ESRRG; ESXI; ESYTI: ESYT2; ESYT3; ETAAI; ETFI; ETFA; ETFB; ETFDH; ETHEI; ETN I: ETNK2; ETNPPL; ETSI: ETS2; ETVI: ETV3; ETV4; ETV5; ETVB; ETV7; EVAIA; EVAIC; EVC2; EVC;
EVI2A; EVI2B; EVI5; EVL; EVPL; EVX1; EVX2; EWSRI: EXO2; EXO3; EXOI; EXOCI; EXOC2; EXOC3LI; EXOC3L2; EXOC4; EXOC5; EXOC7;
[0293] EXOG; EXBSCI; EXDSC2; EXBSC3; EXBSC4; EXDSC5; EXDSCB: EXBSC7; EXDSC8; EXPH5; EXTI; EXT2; EXTL2; EXTL3; EYAI; EYA2; EYA4;
[0294] EYS; EZHI; EZH2; EZR; FID; Fll; FUR; FI2; FI3AI; FI3B; F2; F2R; F2RLI; F2RL2; F2RL3; F5; F7; F8; FB; FA2H; FAAH2; FABPI FABP2; FABP4; 5 FABP5; FABPB; FABP7; FABPB; FADD; FADSI FADS2; FADS3; FAF2; FAHD2A; FAH; FAIM2; FAIM3; FAMID2A; FAMI03AI; FAMID5A;
[0295] FAMID7A; FAMI07B; FAMIO9A; FAMIIBA; FAMIIBB; FAMIIBC; FAMIItB; FAMII4AI: FAMI20B; FAMI2DC; FAMI24B; FAMI2BA; FAMI29A;
[0296] FAMI29B; FAMI34B; FAMI35A; FAMI35B; FAM13BA; FAMI3A; FAMI3C; FAMI49A; FAMI50B; FAMI55A; FAMIBOBI; FAMI6IA; FAMIB3A;
[0297] FAMIB3B; FAMIB7A; FAMIB8A; FAMIB8B; FAMIB9B; FAMI7DA; FAMI72A; FAMI73B; FAMI74A; FAMI75A; FAMI75B; FAMI77AI: FAMI77B;
[0298] FAMI78A; FAMI78B; FAMI79B; FAMI8DA; FAMI84A; FAMI84B; FAMI87B; FAMI88A; FAMI88B; FAMI89B; FAMI93B; FAMIBBA; FAMI9BB; ID FAMI98B; FAMI9AI: FAMI9A2; FAMI9A4; FAMI9A5; FAM2D4A; FAM2D5A; FAM2DA; FAM2DB; FAM20C; FAM2IDB: FAM2I3A; FAM2I4A;
[0299] FAM2IBA; FAM220A; FAM227B; FAM32A; FA 3A: FAM3B; FAM3C; FAM3D; FAM4BA; FAM4BD; FAM49A; FAM49B; FAM5BB; FAM53B;
[0300] FAM57A; FAM58A; FAMBDA; FAMB3B; FAMB4A; FAM65B; FAMBBC; FAM7IFI; FAM7IF2; FAM72B; FAM78B; FAM8IB; FAM83A; FAM83B;
[0301] FAM83D; FAM83H; FAM84A; FAM84B; FAM89A; FAM92AI; FAM92B; FAM9B; FAN1; FANCA; FANCB; FANCC; FANGD2; FANCE; FANCF; FANCG; FANCI; FANCL; FANCM; FANKI; FAP; FARI; FARPI; FARP2; FARS2; FARSA; FAS; FASLG; FASN; FASTKD2; FASTK; FATI; FAT2; FATS; 15 FAT4; FATEI; FALL FBFI; FBL; FBLIMI; FBLNI; FBLN2; FBLN5; FBNI; FBN2; FBN3; FBPI; FBP2; FBRS; FBXLI5: FBXLI7; FBXLI9; FBXL2D;
[0302] FBXL2; FBXL3; FBXL4; FBXL5; FBXL7; FBXOID; FBXDII; FBX0I5; FBXDI7; FBXDI8; FBXD28; FBXD3D; FBXD3I; FBXD32; FBXD33; FBXD38;
[0303] FBXD3; FBXD4D; FBX047; FBXD4; FBX05; FBXD7; FBXD8; FBXD9; FBXWIL FBXW4; FBXW7; FBXW8; FCAR; FCERIA; FCERIG; FCER2;
[0304] FCGBP; FCGR2A; FCGR2B; FCGR3A; FCGR3B; FCGRT; FCHOI; FCHD2; FCHSD2; FCN FCN2; FCRLI; FCRL2; FCRL3; FCRL4; FCRL5;
[0305] FCRLB; FCRLA; FCRLB; FDFTI; FDPS; FDXI; FDXIL; FDXR; FECH; FEMIA; FEMIB; FEMIC; FENI; FERD3L; FER; FERMTI; FERMT2; FERMT3; 0 FES; FEV; FEZI; FEZ2; FEZFI; FEZF2; FFARI; FFAR2; FFAR3; FFAR4; FGA; FGB; FGDI; FGD2; FGD3; FGD4; FGD5; FGDB; FGFID; FBFII; FGFI2;
[0306] FGFI3; FGFI4; FGFIB; FGFI7; FGFI8; FGFI9; FBFI; FGF2D; FGF2I: FGF23; FGF2; FGF3; FGF4; FGF5; FGFB; FGF7; FGF8; FGF9; FGFBPI;
[0307] FGFBP2; FGFBP3; FGFRI; FGFRIDP2; FGFRIDP; FGFR2; FGFR3; FGFR4; FGFRLI; FGG; FGGY; FGLI; FGL2; FGR; FHDCI FH; FHIT; FHLL FHL2;
[0308] FHL5; FHDDI; FHDD3; FIBP; FIG4; FIGF; FIGLA; FIGN; FILIPI; FILIPIL; FIP1L1; FISL FIT I; FITM2; FJXI; FKBPID; FKBPII; FKBPI4; FKBPI5;
[0309] FKBPIA; FKBPIB; FK8P2; FKBP3; FKBP4; FKBP5; FKBPB; FKBP7; FKBP8; FKBP9; FKBPL; FKRP; FKTN; FLADI FLCN; FLG2; FLG; FLU; FLU; 5 FLNA; FLNB; FLNC; FLOTI; FLDT2; FLRT2; FLRT3; FLTI: FLT3; FLT3LG; FLT4; FLVCRI; FLVCR2; FMNL FMN2; FMNLI; FNL2; FMNL3; FHOI:
[0310] FMD2; FMD3; FMD4; FMOD; FMRI; FNI; FN3K; FN3KRP; FNBPI; FNDCI; FNDC3A; FNDC3B; FNDC4; FNTA; FNTB; FDCAD; FOLHI FDLR1;
[0311] FDLR2; FDLR3; FOPNL; FOSB; FDS; FDSLI FDSL2; FOXA1; FOXA2; FOXA3; FOXBI; FOXCI FOXC2; FOXDI; FOXEI; FOXFI; FOXF2; FOXGI;
[0312] FOXHI; FOXII; FDXJI; FDXJ2; FOXKI; FOXK2; FOXLI; FOXL2; FOXMI; FOXNI; FOXN2; FOXN3; FOXOl; FOXO3; FOXO4; FOXOB; FOXPI FOXP2;
[0313] FOXP3; FOXP4; FOXQI; FOXRI; FOXR2; FOXREDI; FPGS; FPRI; FPR2; FPR3; FRASI; FRATI; FRAT2; FREMf FREM2; FREM3; FRGI; FRG2; 0 FRK; FRMD3; FRMD4A; FRMD4B; FRMD5; FRMDB; FRMD7; FRMPDI; FRMPD2; FRMPD4; FRRSIL; FRS2; FRS3; FRY; FRYL; FRZB; FSBP;
[0314] FSCB; FSCNI; FSCN2; FSDI; FSDIL; FSD2; FSHB; FSHR; FSIPI; FST; FSTLI; FSTL3; FSTL4; FSTL5; F D; FTHI FTL; FTMT; FTO; FTSJI;
[0315] FTSJ2; FTSJ3; FUBPI: FUBP3; FUCAt: FOCA2; FUNDCI: FONDC2; FDRIN; FUS; FOTIO; FOTII; FUTI; FDT2; FUT3; FUT4; FUT5; FUTG; FUT7;
[0316] FUT8; FOT9; FUZ; FXN; FXRI; FXR2; FXYDI; FXYD2; FXYD3; FXYD5; FXYDB; FYS; FYCDI; FYN; FZDIO; FZDI; FZD2; FZD3; FZD4; FZD5; FZDB;
[0317] FZD7; FZDB; FZD9; FZRI; GDS2; G2E3; G3BPI; GGPC2; GGPC3; GBPC; GBPD; GAA; GABI; GAB2; GAB3; GABARAP; GABARAPLI; 5 GABARAPL2; GABBRI: GABBR2; GABPA; GABPBI; GABRAI; GABRA2; GABRA3; GABRA4; GABRA5; GABRAB; GABRBI; GABRB2; GABRB3; GABRE; GABRGI; GABRG2; GABRG3; GABRP; GABRQ; GABRRI; GABRR2; GADI; GAO2; GADD45B; GAOD45G; GADD 5GIPI; GADLI;
[0318] GAGEID; GAGEI; GAK; GALC; GAL; GALKI; GALK2; GALN; GALNS; GALNTI2; GALNTI3; GALNTI4; GALNTI5; GALNTI8; GALNTI; GALNT2;
[0319] GALNT3; GALNT4; GALNT5; GALNTB; GALNT7; GALNT8; GALNT9; GALNTLB; GALP; GALRI; GALR2; GALR3; GALT; GAMT; BANAB: GANG;
[0320] GAN; GAP43; GAPDH; GAPDHS; GARI; GAREM; GARNL3; GARS; GART; GASI; GAS2; GAS2LI; GASB; GAS7; GAS8; GAST; GATAI GATA2; GATA3; GATA4; GATA5; GATAB; GATADI GATAO2A; GATAD2B; GATB; GATM; GBA2; GBA; GBAS; GBEI; GBFI; GBGTI; BBXf; GBX2; GCA;
[0321] GCCI; GCDH; GCFC2; GCG; GCGR; GCHI; GCHFR; GC; GCK; GCKR; GCLC; GCMI; GCM2; GCNILI; GCNTI; GCNT2; GCNT3; GCNT7; GCOHI;
[0322] GCSAM; GCSAML; GCSH; GDA; GDAPI; GOEI; GDFIQ; GDFII; GDFI5; GDFI: GDF2; GDF3; GDF5; GDFB; GDF7; GDF9; GDII; GDI2; GDNF;
[0323] GDPD3; GDPO5; GEM; GEMIN2; GEMIN4; GE IN6; GENI GET4; GFAP; GFER; GFIIB; GFII; GFMI; GFPTI; GFPT2; GFRAI; GFRA2; GFRA3; GFRA4; GGAI; GGA3; GGACT; GGCT: GGCX; GGH; GGNBP2: GGN; GGPSI; GGTI; GGT2; GGT5; GGTLCI; GHI; GH2; BHITM; GHRH; GHR; GHRHR; GHRL; GHSR; GID8; GIF; GIGYFI; GIGYF2; GIMAP5; GIMAP7; GIMAP8; GINI; GINSI; GINS2; GIPCI; GIPC3; GIP; GIPR; GITI; GIT2;
[0324] GJAI; GJA3; GJA8; GJBI; GJB2; GJBB; GJCI; GJC2; GJC3; GJD2; GJB3; GK; GKNI: GKN2; GLA; GLBI; GLCCII; GLCE; GLDC; GLDN; GLEI;
[0325] GLGI; GUI: GLI2; GLI3; GLIPRI; GLIPR2; GLIS2; BLISS; GLMN; GLDI: GLDD4; GLPIR; GLP2R; GLRAI; GLRA2; GLRA3; GLRB; GLRX2; GLRX3;
[0326] GLRX5; GLRX; GLS2; GLS; GLTIDI; GLTBDI; GLT8DI; GLTSCRI; GLTSCR2; GLUDI: GLUD2; GLUL; GLYAT; GLYATL3; GLYCTK; GM2A; GMCLI;
[0327] GMDS; GMFB; GMFG; GMIP; GML; GMNN: GMPPA; GMPPB; GMPR2; GMPR; GMPS; GNAII; GNAI2; GNAI3; GNAI4; GNAI5; GNAII; GNAI2; GNAL; GNADI; GNAQ: GNAS; GMATI: GNATS; GNAZ; GNBIL; GNB2LI; GNB3; GNB4; GNB5; GNE; GNGIB; GNGII; GNG2; GNG4; GNG7; GNG8;
[0328] GNGTI; GNGT2; GNU; GNL3; GNL3L; GNLY; GNMT; GNPAT; GNPDAI; GNPDA2; GNPTAB; GNPTG; GNRHI; GNRH2; GNRHR; GNS; GOLGAI;
[0329] GDLGA2; GOLGA3; GDLGA4; GDLGA5; GDLGA8B; GDLGBI; GDLMI; GBLPH3; GBLTIA; GBLTIB; GBN4L; GDPC; GDRAB; GDRASPI;
[0330] GDRASP2; GDSRI; GOSR2; GDTI: GDT2; GPIBA; GPIBB; GP2; GP5; BPS; GP9; GPA33; GPAAI; GPALPPI; GPAM; GPANKI; GPAT2;
[0331] GPATCHI; GPATCH2; GPATCH2L; GPATCH8; GPBARI; GPCI; GPC2; GPC3; GPC4; GPC5; GPCB; GPCPDI; GPDI; GPDIL; GPD2; GPERI; GPHA2; GPHN; GPIHBPI; GPI; GPKOW; GPLDI; GPMBA; GPMBB; GPNI; GPNMB; GPRIDI: GPRIIB; GPRI2; GPRI32; GPRI35; GPRI37C;
[0332] GPRI39; GPR143; GPRI48; GPRI49; GPRI50; GPRI5I; GPRI52; GPR153; GPRI55; GPRI5B; GPRI58; GPRI5; GPRIBO; GPRIGI; GPRIB2;
[0333] GPRI7I; GPRI74; GPRI7B; GPRI7B; GPRI7; GPRI80; GPRI82; GPRI83; GPRI9; GPRI: GPR2D; GPR22; GPR2B; GPR34; GPR35; GPR37;
[0334] GPR37LI; GPR39; GPR4; GPR5D; GPR52; GPR55; GPRB5; GPRB8; GPRB; GPR75; GPR78; GPR83; GPR87; GPRASPI; GPRC5A; GPRC5B;
[0335] GPRC5C; GPRC5D; GPRCBA; GPRINI: GPRIN2; GPRIN3; GPS2; GPSHI: GPSM2; GPSM3; GPT2; GPT; GPX5; GRAMOIB; GRAMB3; GRAMD4; GRAP2; GRAP; GRASP; GRBID; GRBI4; GRB2; GRB7; GREBI; GREMI; GREM2; GRHLI; GRHL2; GRHPR; GRIAI; GRIA2; GRIA3;
[0336] GRIA4; GRIDI; GRID2; GRIKI; GRIK2; GRIK4; GRIK5; GRINI: GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRIN3A; GRIN3B; GRINA; GRIPI; GRKI;
[0337] GRK4; GRK5; GRKB; GRK7; GRMI; GRM2; GRM3; GRM4; GRM5; GRMB; GRM7; GRMB; GRN; GRPELI; GRP; GRPR; GRSFI; GRXCRI; GRXCR2;
[0338] GSC2; GSC; GSDMA; GSDMB; GSDMC; GSDMD; GSEI; GSGIL; GSK3A; GSK3B; GSN; GSPTI; GSPT2; GSR: GSS; GSTAI; GSTA2; GSTA4;
[0339] GSTA5; GSTCD; GSTI GSTM3; GSTDI: GSTD2; GSTPI; GSTTI: GSTT2B; GSTT2; GSTZI; GSXI: GSX2; GTDCI GTF2AI; GTF2AIL; GTF2A2; GTF2EI; GTF2E2; GTF2FI; GTF2F2; GTFZHI GTF2H2C2; GTF2H2C; GTF2H2; GTF2H3; GTF2H4; GTF2H5; GTF2I; GTF2IRDI; GTF2IRD2;
[0340] GTF3A; GTF3CI; GTPBPI: GTPBP3; GTP8P4; GTSFI: GDCA1A; GUCAIB; GUCDI; GUCYIA2; GDCYIA3; GDCYIB3; GUCY2C; GUGY2D;
[0341] GUCY2F; GDKI; GULPI; GDSB; GYGI; GYG2; GYLTLIB; GYPA; GYPB; GYPC; GYPE; GYSI; GYS2; GZFI: GZMA; GZMB; GZMH; GZMK; GZMM;
[0342] HIFD; HIFX; H2AFJ; H2AFX; H2AFY2; H2AFY; H2AFZ; H2BFWT; H3F3B; HAAO; HABP2; HABP4; HACDI HAC02; HACD4; HACEI; HACLI;
[0343] HADHA; HADHB; HADH; HAGH; HAL; HAMP; HANOI; HAND2; HADI: HA02; HAPI; HAPLNI: HAPLN4; HARS2; HARS; HASf HAS2; HAS3; HATI; HAVCRI; HAVCR2; HAXI; HBA2; HBB; HBO; HBEI: HBEGF; HBGI: HBG2; HBM; HBPI; HBQI HBSIL; HBZ; HCARI; HCAR2; HCAR3; HCCS; HCFCI; HCFCZ; HCK; HCLSI; HCNI; HCN2; HCN3; HCN4; HCRT; HCRTRZ; HCST; HDACIO; HDACIt HDACI; HDACZ; HDAC3; HDAC4;
[0344] HDAC5; HDACB; HDAC7; HDAC8; HDAC9; HDC; HDDCZ; HDGF; HDBFLI; HDGF P3; HDHDI; HDLBP; HEAT I; HEATR3; HEATR5B; HEATRB;
[0345] HEBPI; HEBPZ; HECA; HECTDZ; HECTD4; HECWI: HECWZ; HEGI; HELLS; HELQ; HELT; HELZZ; HELZ; HEMGN; HEPACAM; HEPH; HEPNI;
[0346] HERCI; HERC2; HERC3; HERC5; HERCB; HERPUOI; HESI; HES2; HESB; HES7; HESXI; HEXA; HEXB; HEXDC; HEXIMI; HEYI; HEYZ; HFE; 5 HFMI; HGD; HGFAC; HGF; HGHI; HGS; HGSNAT; HHAT; HHATL; HHEX; HHIP; HHIPLI; HHLAI; HHLAZ; HIATI; HIBAOH: HIBGH; HICI; HICZ;
[0347] HIDI; HIFIA; HIFIAN; HIF3A; HIGDIA; HIGDIC; HIGDZA; HILPDA; HINFP; HINTI; H1NT2; HIPI; HIPIR; HIPKI; HIPKZ; HIPK3; HIRA; HIRIP3;
[0348] HISTIHIA; HISTIHIB; HISTIHIC; HISTIHID; HISTIHIE; HISTIHIT; HISTIHZAE; HISTIH2AH; HISTIHZBG; HISTIH2BH; HISTIH2BM; HISTIH3G;
[0349] HISTIH4D; HIST3H3; HIVEPI; HIVEP2; HJURP; HKI; HK2; HK3; HKDCI; HLA-A; HLA-B; HLA-C; H LA-DMA; HLA-DMB; HLA-DOA; H LA-DOB;
[0350] HLA-DPAI; HLA-DPBI; HLA-DQAI; HLA-DQA2; HLA-OQBI: HLA-DOB2; HLA-DRA; HLA-DRBI; HLA-DRB3; HLA-DRB4; HLA-DRB5; HLA-E; ID HLA-F; HLA-G; HLCS; HLF; HLTF; HLX; HMI3; HMBOXI; HMBS; HMCNI; HMG2DA; HMG20B; HMGAI: HMGA2; HMGBI; HMGBZ; HMGB3;
[0351] HMGCR; HMGCSI; HMGNI; HMGN4; HMGN5; HMGXB3; HMGXB4; HMHAI; HMMR; HMOXI; HMDXZ; HMPIB; HMSD; HMXI; HNI; HNIL; HNFIA;
[0352] HNFIB; HNF4A; HNF4G; HNT: HNRNPAO; HNRNPAI: HNRNPAZBI; HNRNPA3; HNRNPAB; HNRNPC; HNRNPD; HNRNPDL; HNRNPF;
[0353] HNRNPHI; HNRNPHZ; HNRNPK; HNRNPL; HNRNPM; HNRNPR; HNRNPU; HNRNPULI: HDGAI; HOMER): HOMERZ; HOMERS: HOMEZ;
[0354] HODKZ; HODK3; HOPX; HORMAD2: HOXAIO; HOXAII; HOXAI3; HOXAI; HOXA2; HOXA3; HOXA4; HOXA5; HOXAB; HOXA7; HOXA9; HOXBI3; HOXBI; HOXB2; HOXB3; HOXB4; HOXB5; HOXB6; HOXB7; HOXB8; HOXB9; HOXC10; HOXCII; HOXCI2; HOXCI3; HOXC4; HOXC5; HOXCB;
[0355] HOXC8; HOXCB; HOXDIO; HOXDII; HOXDI2; HOXDI3; HOXDI: HOXD3; HOXO4; HOXO8; HOXO9; HPIBP3; HPCALI; HPD; HPGD; HPGDS; HP;
[0356] HPN; HPR; HPRTI; HPSI; HPS3; HPS4; HPS5; HPSB; HPSE2; HPSE; HPX; HRAS; HRASLS; HRC; HRG; HRHI; HRH2; HRH3; HRH4; HR;
[0357] HRK; HRNR; HRSPIZ; HSIBP3; HS3STI; HS3STZ; HS3ST3AI; HS3ST3BI; HS3ST4; HS3ST5; HS3STB; HSBSTI; HSBSTZ; HSBST3; HSBPI;
[0358] HSDIIBI; HSOIIBIL; HSDIIB2; HSDI7BIO; HSDI7BII; HSDI7BI2; HSDI7BI3; HSDI7BI4; HSDI7BI; HSDI7B2; HSDI7B3; HSDI7B4; HSDI7B6; HSDI7B7; HSDI7BB; HSD3BI; HSD3B7; HSDLI; HSDL2; HSFI; HSFZ; HSF4; HSF5; HSFY2; HSH2D; HSP90AAI: HSP90ABI; HSP90BI;
[0359] HSPAI2A; HSPAI2B; HSPAI3; HSPAI4; HSPAIA; HSPAIL; HSPA2; HSPA4; HSPA4L; HSPA5; HSPAB; HSPA8; HSPA9; HSPBI: HSPB2;
[0360] HSPB3; HSPBB; HSPB7; HSPB8; HSPB9; HSPBAPI; HSPBPI HSPDI; HSPEI: HSPG2; HSPHI; HTATIPZ; HTNI; HTN3; HTRIA; HTRIB;
[0361] HTRIE; HTRIF; HTRZA; HTRZB; HTRZC; HTR3A; HTR3B; HTR3C; HTR3D; HTR3E; HTR4; HTR5A; HTR7; HTRAI; HTRAZ; HTRA3; HTRA4;
[0362] HTT; HUNK; HUSIB; HUSI; HUWEI; HVCNI; HYALI; HYALZ; HYAL3; HYAL4; HYDIN; HYKK; HYLSI; HYOUI: HYPM; IAPP; IARS2; IARS; IBA57; 5 IBSP; IBTK; ICAI; ICAMI; ICAMZ; ICAM3; ICAM4; ICAM5; ICEI ICE2; ICK; ICMT; ICOS; ICOSLG; IDI ID2; 104; IDE; IDHI; IDH2; IDH3B; IDNK;
[0363] IDOI; ID02; IDS; IDUA; IER2; IER3; IER3IPI; IER5; IFFOI: IFFOZ; IFIIB; IFIZ7; IF130: IF135: IF144; IFIHI; IFITI; IFITZ; IFIT3; IFIT5: IFITMI;
[0364] IFITMZ; IFITM3; IFITM5; IFNAIO; IFNAI3; IFNAI4; IFNAIB; IFNAI7; IFNAI; IFNAZI; IFNA2; IFNA4; IFNA5; IFNAG; IFNA7; IFNA8; IFNARI:
[0365] IFNAR2; IFNBI; IFNE; IFNG; IFNGRI; IFNGR2; IFNK; IFNLI: IFNL2; IFNL3; IFNWI; IFRDI; IFTI22; IFTI40; IFTI72; IFT27; IFT43; IFT57; IFT74;
[0366] IFT80; IFT88; IGBPI; IGDCC3; IGFI; IGFIR; IGF2BPI; IGF2BP2; IGF2BP3; IGF2; IGF2R; IGFALS; IGFBPI; IGFBP2; IGFBP3; IGFBP4; IGFBP5; 0 IGFBPB; IGFBP7; IGFBPLI; IGFLI: IGFLRI; IGHMBP2; IGJ; IGLLI; IGSFIO; IGSFII; IGSFI; IGSF5; IGSFB; IGSF8; IHH; IKB AP; IKBKB; IKBKE;
[0367] IKBKG; IK; IKZFI; IKZF2; IKZF3; IKZF4; ILIO; ILIORA; ILIORB; ILII; ILIIRA; ILIZA: ILI2B; ILI2RBI; IL13; ILI3RAI; ILI3RA2; IL15: ILI5RA; ILIB;
[0368] ILI7A; ILI7B; ILI7C; ILI7D: ILI7F; ILI7RA; ILI7RB; ILI7RC; ILI7RD; ILI7RE; ILI7REL; ILI8BP; ILI8: ILI8RI; ILI8RAP; ILI9; ILIA; ILIB; ILIFIO;
[0369] ILIRI; ILIRZ: ILIRAP; ILIRAPLI: ILIRAPLZ; ILIRLI; ILIRLZ; ILIRN; ILZO; ILZDRA; ILZORB; ILZI; ILZIR; ILZZ; IL22RA2; ILZ3A; IL23R; IL24;
[0370] IL25; IL2B; IL27; ILZ7RA; IL2: IL2RA; IL2RB; IL2RG; IL3I; IL3IRA; IL32; IL33; IL34; IL3BA; IL3BB; IL3GG; IL3GRN; IL37; IL3: IL3RA; IL4; 5 IL4II; IL4R; IL5; IL5RA; ILB; ILBR; ILBST; IL7; IL7R; IL9: IL9R; ILDRI; ILDRZ; ILFZ; ILF3; ILK; IMMPIL; IMMPZL; IMMT; IMPS; IMPAI; IMPAZ; IMPACT; IHPAD!; IMPDHI; IMPDH2; IMPBI; IMPG2; 1NADL: INA; INCENP; INF2; INGI; ING2; ING3; ING4; ING5; 1NHA; INHBA; INHBB; INHBC; INHBE; INB8BB; INOSDD; IND8D; INPPI INPP4A; INPP4B; INPP5A; INPP5B; INPP5D; INPP5E; INPP5F; INPP5K; INPPLI; INSC: INS; INSIGI; INSIG2; INS-IGF2; INSL3; INSL4; INSLB; INSMI INSM2; INSR; INSRR; INTSI2; INTSI; INTS2; INTS3; INTS4; INTS5; !NTSB; 1NTS7; INTS8; INTU; INVS; !PBKI; IP6K2; IPGK3; IPCEFI; IPM; IPBtl; IPDI3; IPB7; IPB8; IPB9; IDCBI; IDCG; IQCH; IQCJ; IDCJ-SCHIPI IflC; IDGAPI; IBGAP2; IQGAP3: IDSECI: IQSEC2; IQSEC3; IRAKIBPI; IRAKI; IRAK2; IRAK3; IRAK4; IREB2; IRFI; IRF2BP2; IRF2BPL; IRF2; IRF3; IRF4; IRF5; IRFB; IRF7; IRF8; IRF9; IRGI IRGM; IRSI; IRS2; IRS4; IRXI; IRX2; IRX3; IRX4; IRX5; ISCU; ISG2B; ISLI; ISMI ISM2; ISPD; ISTI; ISX; ISYNAI; ITCH; ITFGI; ITFG3; ITGAIO; ITGAII; ITGAI; ITGA2B; ITGA2; ITGA3; ITGA4; ITGA5; ITGAB; ITGA7; ITGA8; ITGA9; ITGAD; ITGAE; ITGAL; ITGAM; ITGAV; ITGAX; ITGBIBPI; ITGBI; ITGB2; ITGB3; ITGB4; ITGB5; ITGBB; ITGB7; ITGB8; ITGBLI; ITIHI; ITIH2: ITIH3; ITIH4; ITIH5: ITK; ITLNI: ITLN2; ITM2A; ITM2B; ITM2C; ITPA; ITPKt; ITPKA; ITPKC; ITPRI; ITPR2; ITPR3; ITSNI; ITSN2; IVD: IVL; IVNSIABP; IYD: IZUMBI; JAOEI; JADE2; JABI JAG2; JAGNI; JAK2; JAK3; JAK IPI: JAKMIP2; JAKMIP3; JAM2; JAM3; JARID2; JAZFI JDP2; JMJOIC; JMJDB; JMY; JPH2; JPH3; JPH4; JR; JS PI; JTB; JUNB; JUNO; JUP; KALI; KALRN; KANKI; KANK2; KANK4; KANSLI: KANSL3; KARS; KAT2A; KAT2B; KAT5; KATBA; KATBB; KAT7; KAT8; KATNAI; KATNAL2; KATNBI; KAZALDI; KAZN; KBTBDII: KBTBDI3; KBTBD8; KCMFI; KCHAI: KCNA4; KCNA5; KGNAB; KCNA7; KCNABI: KCNAB2; KCNAB3; CNBI; KCNB2; KCNCI; KCNC2; KCNC3; KCND2; KCNEi KCNE2; KCNE3; KCNE4; KCNE5; KCNG3; KCNG4; CNHI; KCNH2; KCNH3; KCNH4; KCNH5; KCNHB; KCNH7; KCNH8; KCNIPI; KCNIP2; KCNIP3; KCNIP4; KCNJID; KCNJ1I; KCNJ12; KCNJI3; KCNJ14; KCNJI5; KCNJIB; KCNJI8; KCNJi; KCNJ2; KCNJ3; KCNJ4; KCNJ5; KCNJ6; KCNJB; KCNJ9; KCNKIB; KCNKI2; KCNKIB; KCNKI7; KCNKI8; CNKI; KCNK2; KCNK3; KCN 5; KGNKB; KCNK9; KCNMAI; KCN BI; KCNMB2; KCNMB3; KCNMB4; KCNNI; KCNN2; KCNN3; KCNN4; KCNOI; KCNO2; KCNO3; KCNQ5; KCNRG; KCNSI; KCNS3; KCNTI; KCNT2; CNUI; KCNVI; KCNV2; KCTDID; CTDII; KCTDI2; KCTOI3; KCTDI5; KCTDIB; KCTDI; KCTD2I; KCTD2; KCTD3; KCTDB; KCTD7; KCTD9; KDELCI: KDELRI; KDM2A; KDM2B; KDM3A; KDM3B; KDM4B; KDM4C; KDM5A; KDM5B; KDM5C; KDM5D; KDMBA; KDMBB; KDR; KOSR; KEAPI; KEL; KERA; KHDC3L; KHDRBS2; KHBRBS3; KHK; KHSRP; KIAADB2B; KIAAQD4D; KIAADIBD; KIAADIDI KIAADIBB; KIAAD22G; KIAAD22BL; KIAAD232; KIAAD3I9; KIAAD3I9L; KIAAD355; KIAAD3BI; KIAAB58G; KIAAD825; KIAAD9D7; KIAAD922; KIAAID24; KIAAI033; KIAAIIO9; KIAAII47; KIAAIIBI; KIAAI2II; KIAAI2IIL; KIAAI2I7; KIAAI279; KIAAI324; KIAAI324L; KIAAI377; KIAAI45B; KIAAI4B2; KIAAI4B8; KIAA1524; KIAA1549; KIAAI55I; KIAA1598; KIAAI7I5; KIAAI8D4; KIAAI84I; KIAAI9I9; KIAA2D22; KIDINS220; KIFII; KIFI3A; KIFI4; KIFI5: KIFIBB; KIFI7; KIFI8A; KIFIA; KIFIC; KIF20A; KIF2BB; KIF2IA; KIF2IB; KIF22; KIF23; KIF24; KIF25; KIF2BA; KIF2BB; KIF2A; KIF2B; KIF2C; KIF3A; KIF3B; KIF3C; KIF4A; KIF4B; KIF5A; KIF5B; KIF5C; KIFB; KIF7; KIF9; KIFAP3; KIFCI; KIFC3; KIN; KIR2DLI; KIR2DL2; KIR2DL3; KIR2DL4; KIR2DL5A; KIR2DL5B; KIR2DSI; KIR2DS2; KIR2DS3; KIR2DS4; KIR3DLI; KIR3DL2; KIR3DL3; KIRREL2; KIRREL3; KIRREL; KISSI; ISSi; KIT; KITLG; KLB; KLCI; KLFID; KLFII KLFI2; KLFI3; KLFI4; KLFI5; KLFIB; KLFI KLF2; KLF3; KLF4; KLF5; KLFB; KLF7; KLF8; KLF9; KLHDCI; KLHDC2; KLHDC8A; KLHDC8B; KLHLIO; KLHLI2; KLHLI; KLHL2D; KLHL25; KLHL2B; KLHL29; KLHL2; KLHL3I; KLHL35; KLHL3; KLHL40; KLHL4I; KLHL42; KLHL5; KLHLB; KLHL7; KLHLB; KL; KLKIO; KLKII; KLKI2; KLKI3; KLKI4; KLKI5; KLKI; KLK2; KLK3; KLK4; KLK5; KLKB; KLK7; KLK8; KLK9; KLKBI; KLLN; KLRBI; KLRCI; KLRC2; KLRC4; KLRC4-KLRKI: KLRDI; KLRGI; KLRG2; KMD; KMT2A; KMT2B; KMT2C; KMT2D; KMT2E; KNGI; KNSTRN; KNTC1; KPNAI; KPNA2; KPNA3; KPNA4; KPNAB; KPNA7; KPNBI; KPRP; KPTN; KRAS; KRBOX4; KREMEN1; KRITI; KRTID; KRTI2; KRTI3; KRTI4; KRTI5; KRTIB; KRTI7; KRTI8; KRTI9; KRTI; KRT2D; KRT23; KRT2; KRT3I: KRT32; KRT34; KRT35; KRT3; KRT4; KRT5; KRTBA; KRTBB; KRTGC; KRT7I; KRT72; K T74; KRT75; KRT7B; KRT78; KRT7; KRT8D; KRT8I; KRT82; KRT83; KRT85; KRT8G; KRT8; KRT9; KRTAPII-I; KRTAP5-I; KRTAP5-9; KSRI KSR2; TNI; KYNU; LICAM; L2HGDH; L3MBTLI; L3MBTL2; L3MBTL3; L3MBTL4; LACCI; LACEI; LACRT; LACTB; LADI; LAG3; LAIRI: LAIR2; LALBA; LAMAI; LAMA2; LAMA3; LAMA4; LAMA5; LAMB!: LAMB2; LAMB3; LAMB4; LA CI; LAMC2; LAMC3; LAMP1: LAMP2; LAMP3; LAMTORI; LAMTQR2; LAMTOR3; IANCLI: LANCL2; LAP3; LAPTM4B; LARGE; LARP1;
[0371] LARP4; LARPG; LARP7; LARS2; LARS; LASIL; LASPI; LAT2; LAT; LATSI; LATS2; LAXI; LAYH; LBH; LBP; LBR; LBXI LBX2; LCA5; LCAT;
[0372] LCEIC; LCE3A; LCE3B: LCE3C; LCE3D; LCE3E; LCE5A; LCK; LCLATI; LCMTI; LCNI: LCN2; LCOR; LCPt: LCP2; LCT; LDBI; LDB2; LDB3;
[0373] LDHA; LDHALBB; LDHB; LDHC; LDHD; LDLRAD3; LDLRAD4; LDLR; LDDCI; LDDCIL; LEAP2; LECT1; LECT2; LEFI; LEFTYI; LEFTY2; LEKRI; LEMD2; LEMD3; LEDI; LEP; LEPRDTLI; LETMI; LETMDI; LEUTX; LFNG; LGALSI2; LGALSI3; LGALSI4; LGALSIB; LGALSI; LGALS2; LGALS3BP;
[0374] LGALS3; LGALS4; LGALS7B; LGALS8; LGALSB; LGALSL; LGII; LGI2; LGI4; LGMN; LGR4; LGR5; LGRB; LGSN; LHB; LHCGR; LHFP; LHFPLI:
[0375] LHFPL2; LHFPL3; LHFPL4; LHFPL5; LHPP; LHXI; LHX2; LHX3; LHX4; LHX5; LHXB-. LHX9; LIAS; LIE; LIFR; LIGI; LIG3; LIG4; LILRAI; LILRA2;
[0376] LILRA3; LILRA4; LILRA5; LILRBI; LILRB2; LILRB3; LILRB4; LILRB5; LIM2; LIMAI: LIMCHI; LIMDI; LIND2; LIMKI; LI K2; LIMSI; LIMS2;
[0377] LIN28B; LIN52; LIN7A; LIN7B; LIN7C; UNO; LINGDI; LING02: LINGB4; LINS; LIPA; LIPC; LIPE; LIPF; LIPG; LIPH; LIPI; LIPN; LIPTI: LIPT2; LITAF; LIXI; LLGLI; LLGL2; LMANI; LMANIL: LMAN2L; LMBRI; LMBRDI; LMBRD2; L CDI; LMFi: LMLN; LMNA; LMNBI L NB2; LMNTDI; LMOI;
[0378] LMO2; LMO3; LMO7; LMODI; LDD3; LMTK2; LT3; LMXIA; LMXIB; LNPEP; LNXI; LNX2; LDCID02889BB; LOCIOIOBD32I;
[0379] LDCID2723475; LOCI0272399B; LOCI02724127; LDC1027245BD; LDC102724770; LQC1027250IB; LOCID2725035; LDC400499;
[0380] LOC400927-CSNKIE; LOCB45I77; LONPI; LONRFI LOR; LOXHDI: LOX; LOXLI; LOXL2; LOXL3; LOXL4; LPA; LPARI; LPAR2; LPAR3; LPARB;
[0381] LPCATI; LPCAT2; LPCAT3; LPCAT4; LPGATI; LPINI; LPIN2; LPL; LPD; LPP; LPPR2; LPPR4; LPXN; LRAT; LRBA; LRCHI; LRCH4; LRFN2; LRFN5; LRGI; LRGUK; LRIFI; LRIGI; LRIG3; LRITI; LRIT3; LRMP; LRPID; LRPI2; LRPIB; LRPI; LRP2BP; LRP2; LRP4; LRP5; LRPB; LRPAPI;
[0382] LRPPRC; LRRI; LRRCI5; LRRCIBA; LRRCIBB; LRRCI7; LRRCI8; LRRCI; LRRC2D; LRRC2B; LRRC3D; LRRC32; LRRC37A; LRRC37B;
[0383] LRRC39; LRRC49; LRRC4B; LRRC4C; LRRC4; LRRC52; LRRC59; LRRCBI; LRRCB3; LRRCB9; LRRCB; LRRC74A; LRRC7; LRRC8A;
[0384] LRRC8C; LRRCCI; LRRFIPI; LRRFIP2; LRR I; LRRK2; LRRNI; LRRN2; LRRN3; LRRN4; LRRTMI; LRRTM2; LRRTM3; LRRTM4; LRSAMI;
[0385] LRTMI; LRTDMT; LSAMP; LSMII: LSMI: LSM2; LSM3; LSM4; LS 5; LSMB; LSM7; LSPI; LSR; LSS: LSTI; LTA4H; LTA; LTB4R2; LTB4R: LTB; LTBPI; LTBP2; LTBP3; LTBP4; LTBR; LTC4S; LTF; LTK; LOC7L3; LOC7L; LUM; LURAPIL; LUZP4; LOZPB; LVRN; LXN; LYBD; LYBE; LYBG5B;
[0386] LYBG5C; LYBGBC; LYBGBF; LYB; LY75-CD302; LY75; LY8B; LY9B; LY9; LYL1; LYN; LYNX; LYPDI; LYPD2; LYPD3; LYPD4; LYPD5;
[0387] LYPOB; LYPD8; LYPLAI; LYPLALI; LYRM1: LYR 4; LYRM7; LYRM9; LYST; LYVEI; LYZ; LYZLI; LYZL2; LYZLB; LZTFLI: LZTRI: LZTSI; MBPR;
[0388] MAATSI; MAB2ILI; MAB2IL2; MAB2IL3; MACCI; MACRDDI; MACROD2; MAOILI; MAD2LIBP; MAO2LI; MAD2L2; MADCAMI; MAOD; MAEA:
[0389] MAEL; MAPI; MAFA; MAFB; MAFF; MAFG; MAF; MAFK; MAGEAIO; MAGEAII; MAGEAI2; MAGEAI; MAGEA2B; MAGEA3; MAGEA4; MAGEAB; MAGEA9; MAGEBI7; MAGEBI; MAGEB2; MAGEBB; MAGECI; MAGEC2; MAGEC3; MAGEDI; MAGED2; MAGED4B; MAGED4; MAGEEI; MAGEHI;
[0390] MAGEL2; MAG; MAGII; MAGI2; MAGI3; MAGTI; MAKIB; MAK; MAL; MALL; MALRDI; MALTI; MAMLI; MAML2; MAML3; MAMLOI MANIAI;
[0391] MANIBI; MAN2AI MAN2A2; MAN2BI; MAN2CI MANBA; MANEA; MANF; MANSCI; MAOA; MAOB; MAPIO; MAPIA; MAPIS; MAPILC3A;
[0392] MAPILC3B2; MAPILC3B; MAPIS; MAP2; MAP2KI; MAP2K2; MAP2K3; MAP2K4; MAP2K5; MAP2 B; MAP2K7; MAP3KIO; MAP3KII; MAP3KI2; MAP3KI3; MAP3KI4; MAP3KI9; MAP3KI; MAP3K2; MAP3K3; MAP3K4; MAP3K5; MAP3 KB; MAP3K7CL; MAP3K7; MAP3K8; MAP3K9; MAP4; MAP4KI; MAP4K2; MAP4K3; MAP4K4; MAP4K5; MAPG; MAP7; MAPS: MAPKIO; MAPKII; MAPKI2; MAPKI3; MAPKI4;
[0393] MAPKI5; MAPKI; MAPK3; MAPKB; MAPK7; MAPKB; MAPK8IPI; MAPK8IP2; MAPK8IP3; MAPK9; MAPKAPI: MAPKAPK2; MAPKAPK3;
[0394] MAPKBPI: MAPREI; MAPRE2; MAPRE3; MAPT: MARCI; MARC2: MARCHI; MARCH2-, MARCH5; MARCHB; MARCH7; MARCH8; MARCKS;
[0395] MARCO; MARKI; MARK2; MARK3; MARK4; MARS2; MARS; MARVELDI; MARVELD2; MARVELD3; MASI; MASIL; MASPI; MAST2; MAST4;
[0396] MASTL; MATIA; MAT2A; MAT2B; MATK; MATN2; MATN3; MATR3; MAU2; MAVS; MAX; MAZ; MB2IDI; MB2ID2; MBDI; MBD2; MBD3; MBD3L2; MBD4; MBD5; MBDB; MB; MBIP; MBL2; MBNLI; MBNL2: MBDATI; MBOAT2; MBDAT4; MBP; MBTDI; MBTPSI; MBTPS2; MCIR; MC2R; C3R; MC4R; MC5R; MCAM; MCAT; MCCCI; MCCCZ; MCCDI: MCC; MCEE; MCP2; NCF2L2; CF2L; MCFD2; MCHRI; MCHR2;
[0397] MCIDAS; MCMIO; CM2: MCM3AP; MCM3; MCM4; MCM5; MCMG; CM7; CM8: MCM9; CMBP; MCDLNI; MCOLN3; MCPHI; MCRSI;
[0398] MCTPI MCTP2; MCTSI: MCG; MCURI; MDCI; DFIC; DFI; MDGAI; MDGA2; MDHI: MDH2; MD; MDMI: MDM2; MDM4; MEL: ME2; ME3;
[0399] MEAI: MECDM; MECP2; MEDI2; MEDI2L; MEDI3; MEDI3L; MEDI4; MEDI5; MEOIG; MEDI7; MEDI9; MEDI; MED22; MED23; MED24; MED25: MED28; MED29; MED3D; MED4; MEDG; MED9; MEF2A; MEF2B; MEF2BNB-MEF2B; MEF2C; MEF2D; MEFV; MEGFIO; MEGFII; MEGF8;
[0400] MEGF9; MEI1; MEISI; MEIS2; MELK; MEMDI; MENI; MEDXI; MEOX2; MEPIA; MEPE; MERTK; MESDCI; MESDC2; MESP2; MEST; METAPID;
[0401] METAPI; METAP2; MET; METRN; METTLI3; METTLIG; METTLI7; METTLI8; METTLI; METTL2IA; METTL2IB; METTL2IC; METTL24; METTLE;
[0402] METTL7A; METTL9; MEX3B; MEX3C; MEX3D; MFAP3; MFAP4; MFAP5; MFGE8; MFHASI: MFI2; MFNI; MFRP; MFSDII: MFSDI2; MFSDI
[0403] MFSOG; MFSD7; MFS08; MGA; MGAM; MGARP; MGATI; MGAT2; MGAT3; MGAT4A; MGAT4B; MGAT4C; MGAT5B; MGAT5; MGEA5; MGLL; MGMEI; MGMT; MGP; MGRNf: MGSTI; MGST2; MGST3; MIA2; MIA3; MIA; MIBI; MIB2; MICA; MICAL2; MICALCL; MICB; MICUI; MICU3; MIDI;
[0404] MID2; MIENt: MIER2; MIER3; MIF; MILRI; MINA; MINKI; MINPPI; MIDX: MIPEP; MIP; MIPDLI; MIRI-IHG; MISI8BPI; MITF; MIXLI; MKIG7;
[0405] MKKS; MKLI; MKL2; MKLN1; MKNKI; MKNK2; MKRNI; MKRN3; MKSI; MLANA; MLCI; MLEC; MLFI; MLF2; MLHI: MLH3; MLKL; MLLTIO; MLLTI;
[0406] MLLT3; MLLT4; MLLTG; MLN; MLNR; MLPH; MLST8; MLX; MLXIP; MLXIPL; MLYCD; MMAA; MMAB; MMADHC; MMD2; MMD; MME; MMELI;
[0407] MMPID; MMPII; MMPI2; MMPI3; MMPI4; MMPI5; MMPIG; MMPI7; MMPI9; MMPI; MMP20; MMP2I; MMP24; MMP25; MMP2B: MMP28; MMP2; MMP3; MMP7; MMP8; MMP9; MMRNI; MMRN2; MMSI9: MMS22L; MNI; MNATI; MNDA; MNSI: MNT; MNXI; MDAPI; MDBIA; MDBIB;
[0408] MDB2; MOB3B; MOB4; MOBP; MOCDS; MOCSI; MOCS2; MOGATI; MOGAT2; MOGAT3; MOG; MOGS; MDK; MONIA; MONIB; MDN2; MDRC3;
[0409] MDRF4LI; MORNI; MORN2; MDRN5; MOS; MOVIOLI: MPCI; MPC2; MPDUt; MPDZ; MPEGI: MPG; MPHDSPHIO; MPHDSPHB; MPHDSPH8;
[0410] MPHDSPH9; MPI; MPLKIP; MPD; MPPI; MPP2; MPP3: MPP5; MPP7; MPPEI; MPPED2; MPRIP; MPST; MPVI7; MPVI7L2; MPZ; MPZLI;
[0411] MPZL2; MPZL3; MRI; MRAP2; MRAP; MRAS; MRCI MRC2; MREIIA; MREG; MRFAPI: MRGBP; MRGPRF; MRGPRXI; MRGPRX3; MRGPRX4; MRU; MRMI; MR0H2B: MRO; MRPLIO; MRPL1I; MRPLI3; MRPLI5; MRPLI7; MRPLI9; MRPLI; MRPL23; MRPL28; MRPL33; MRPL3B; MRPL3;
[0412] MRPL4D; MRPL4I; MRPL44; MRPL4B; MRPL52; MRPL9; MRPSII; MRPSI2; MRPSIG; MRPSI8B; MRPS22; MRPS23; MRPS28; MRPS30;
[0413] MRPS3I; MRPS33; MRPSB; MRPS7; MRPS9; MRRF; MRS2; MRVII; MS4AI2; MS4AI; MS4A2; MS4A3; MS4A4A; MS4AGA; MS4A8;
[0414] MSANTD3-TMEFFI; MSC; MSGNI; MSH2; MSH3; MSH5; MSHB: MSII; MSI2; MSLN; MSMB; MSMOI; MSMP; MSN; MSRI; MSRA; MSRB2;
[0415] MSRB3; MSTI; MSTIR; MSTN; MSTDI; MSXI; MSX2; MTIA; MTIB; MTIE: MTIF; MTIG; MTIH; MTIM; MTIX; MT2A; MT3; MT4; MTAI MTA2; MTA3; MTAP; MTBP; MTCHI: MTCH2; MTCLI; MTCPI; MTDH; MTERFI; MTFI MTFMT; MTFPI; MTGI; MTHFDI; MTHFDIL; MTHFD2; MTHFR;
[0416] MTHFS; MTIF2; MTIF3; MTL5; MTMI: MTMRII; MTMRI2; MTMRI4; MTMRI; MTMR2; MTMR3; MTMR4; MTMRG; MTMR7; MTMR8; MTMR9;
[0417] MTNRIA; MTNRIB; MTDI; MTPAP; MTPN; MTRFI; MTR; MTRNR2L7; MTRR; MTSSI; MTTP; MTDRN; MTUSI; MTUS2; MTXI; MTX2; MUCI2;
[0418] MDCI3; MUCI5; MUCI7; MUCI9; MUCI; MUC2D; MUC2I; MUC22; MUC2; MUC3A; MUC4; MOC5AC; MDC5B; MUCB; MDC7; MUCLI MUMI;
[0419] MDRC; MUS8I; MUSK; MOT; MUTYH; MVBI2B; MVD; MVK; MVP; MXI; MX2; MXDI; MXD3; MXD4; MXII; MXRA5; MYADM; MYBBPIA; MYB; MYBLI; MYBL2; MYBPCI; MYBPC2; MYBPC3; MYBPH; MYCBP2; MYCBPAP; MYC; MYCN; MYCTI; MYD88; MYDGF; MYEF2; MYEOV; MYF5;
[0420] MYFG; MYHIO; MYHII; MYHI3; MYHI4; MYHI5; MYHI MYH2; MYH3; MYH4; MYHG; MYH7B; MYH7; MYH8; MYH9; MYLI2A; MYLI2B; MYLI;
[0421] MYL2; MYL3; MYL4; MYLG; MYL7; MYL9; MYLIP; MYLK2; MYLK3; MYLK; MYLPF; MYNN; MYDID; MYDI5A; MYOIG; MY0I8B; MYDIA; MYOIB;
[0422] MYDIC; MYDID; MYDIE; MYDIF; MYD3A; MYD3B; MY05A; MY05B; MYD5C; MYDG; MYD7A; MYD7B; MYD9A; MYD9B; MYDCD; MYOC;
[0423] MYODI; MYDF; MYDG; MYDMI; MYOM2; MYOT; MYOZI; MYDZ2; MYDZ3; MYPN; MYRF; MYRFL; MYRIP; MYTI; MYTIL; MYZAP; MZBI MZFI; N4BPI; N4BP2LI; N4BP2L2; NAAID; NAAI5; NAAIB; NAA20; NAA25; NAA30; NAA35; NAA4D; NAA50; NAAGD; NAAA; NAALAD2; NAALAOLI; NAALADL2; NASI NAB2; NABPf; NABP2; NACA; NACCi; NACC2; NAOSYNI; NAEI; NAFI; NAGA; NAGK; NAGLU; NAGPA; NAGS;
[0424] NAIP; NALCN; NA PT; NANOG; NANDSI; NANDS2; NANOS3; NANS; NAPILI: NAPIL3; NAPIL4; NAPIL5; NAPA; NAPEPLD; NAPG; NAPRT;
[0425] NAPSA; NARFL; NARR; NA S; NATID; NATI4; NATI; NAT2; NATB; NAT8B; NATS; NAT8L; NAVI NAV2; NAV3; NBAS; MBEA; NBEALi;
[0426] NBEAL2; NBN; NBPF3; NBRI; NCALD; NCAMI; NCAM2; NCAN; NCAPD2; NCAPD3; NCAPG2; NCAPG; NCBP2; NCEHI; NCFI; NCF2; NCF4; 5 NCKI: NCK2; NCKAPI; NCKAPIL; NCKAP5; NCKIPSD; NCL; NCOAI; NCDA2; NCOA3; NCOA4; NCDA5; NCDAB; NCDA7; NCDRI; NCDR2;
[0427] NCRI; NCR2; NCR3; NCR3LGI; NCSI; NCSTN; NDC8D; NDEI; NDELI; NDFIPI; NDFIP2; NDNF; NDN; NDP; NDRGI; NDRG2; NDRG3; NDRG4;
[0428] NDSTI; NDST2; NDST3; NDST4; NDUFAID; NDUFAII; NDUFAI2; NDUFAI3; NDUFAI; NDUFA2; NDUFA5; NDUFAB; NDUFAB; NDUFABI;
[0429] NDUFAFI; NDUFAF2; NDUFAF3; NDUFAF4; NDUFAF5; NDUFAFB; NDUFBID; NDUFBII: NDUFB2; NDUFB3: NDUFB4; NDUFB5; NDUFBB;
[0430] NDUFB8; NDUFBB; NDUFC2; NDUFSI; NDUFS2; NDUFS3; NDUFS4; NDUFSB; NDUFS7; NDUFSB; NDUFV1; NDUFV2; NDUFV3; NEB; NEBL; ID NECABI; NECAB3; NECAPI; NEDDI; NEDD4; NEDD4L; NEDD8; NEDD9; NEFH; NEFM; NEILI; NEIL2; NEIL3; NE IO; NEKII; NEKI: NEK2; NEK3;
[0431] NEK4; NEKB; NE 7; NE 8; NEK9; NELFA; NELFB; NELFCD; NELFE; NELLI; NELL2; NEMF; NEDI; NES; NETI; NETOI; NETD2; NEW; NEU3;
[0432] NEURLI; NEURL2; NEURODI; NELIROD2; NEURDD4; NEURDDB; NEURDGI; NEURDG2; NEURDG3; NFI; NF2; NFAMI; NFASC; NFAT5; NFATCI
[0433] NFATC2; NFATC3; NFATC4; NFE2; NFE2LI: NFE2L2; NFE2L3; NFIA; NFIB; NFIC; NFIL3; NFIX; NFKBI; NFKB2; NFKBIA; NFKBIB; NFKBIE;
[0434] NFKBILI; NFKBIZ; NFRKB; NFSI: NFUI; NFYA; NFYB; NFYC; NGB; NGDN; NGEF; NGF; NGFRAPI; NGFR; NGLYI; NHEJI; NHLHI; NHLRCI 15 NHLRC3; NHP2; NHP2LI; NHS; NHSLI; NICNI; NIDI; NID2; NIF3LI; NIMIK; NIN; N1NJI: NINJ2; NINL; NIPAI; NIPA2; NIPAL3; NIPAL4; NIPBL;
[0435] NIPSNAPI; NIPSNAP3B; NISCH; NITI; NIT2; NKAIN2; NKAIN3; NKAP; NKDI; NKD2; NKG7; NKIRASI; NKIRAS2; NKRF; NKTR; NKXI-I; NKXI-2;
[0436] NKX2-I; NKX2-2; NKX2-3; NKX2-5; NKX2-B; NKX2-8; NKX3-I; NKXB-I; NKXB-2; NLEI; NLGNI; NLGN2; NLGN3; NLGN4X; NLGN4Y; NLK;
[0437] NLN; NLRC3; NLRC4; NLRC5; NLRPIO; NLRPII; NLRPI2; NLRPI3; NLRPI4; NLRPI; NLRP2; NLRP3; NLRP4; NLRP5; NLRPB; NLRP7; NLRP8;
[0438] NLRP9; NMB; NMBR; NMEI; NMEI-NME2; NME2; NME3; NME4; NME5; NMEB; NME7; NME8; NME9; NMI; N NATI; N NAT2; NMNAT3; NMS; NMTI; NMT2; N U; NMURI; NMUR2; NNAT; NNMT; NNT; NOAf; NOBI; NDBDX; NDC3L; NODI: NDD2; NODAL; NOG; NOLII NDL3; NDL4;
[0439] NOLB; NDL8; NOLCI; NDMI ND OI; NOND; NOPID; NDPI4; NDPIB; NOP2; NDP5G; NDPB; NOSIAP; NOSI; NDS2; NOS3; NOSIP; NDSTRIN;
[0440] NOTCHI; NOTCH2; NOTCH3; NOTCH4; NOTUM; NDVAI NOVA2; NOV; NOX1; NOX3; NOX4; NOX5; NOXAI NOXDI; NPAPI; NPAS2; NPAS3;
[0441] NPAS4; NPAT; NPB; NPBWRI; NPCI; NPCILI: NPC2; NPDCI; NPEPLI; NPEPPS; NPFF; NPFFR2; NPHPI; NPHP3; NPHP4; NPHSI NPHS2;
[0442] NPL; NPLOC4; NPMI; NPM2; NPNT; NPPC; NPRI; NPR2; NPR3; NPRL2; NPRL3; NPS; NPSRI; NPTN; NPTXI; NPTX2; NPTXR; NPVF; NPW; 5 NPYIR; NPY2R; NPY5R; NPY; NODI; NDD2; NROBI; NRIDI; NRID2; NRIH2; NRIH3; NRIH4; NRII2; NRII3; NR2CI NR2C2; NRZEI; NR2E3;
[0443] NR2FI; NR2F2; NR2FB; NR3CI; NR3C2; NR4AI; NR4A2; NR4A3; NR5AI: NR5A2; NRGAI; NRAP; NRARP; NRBPI; NRBP2; NRCAM; NRDI
[0444] NRDE2; NREP; NRFI; NRGI; NRG2; NRG3; NRG4; NRGN; NRIPI; NRIP2; NRK; NRL; NRM; NRNI NRPI; NRP2; NRSNI; NRSN2; NRTN; NRXNI;
[0445] NRXN2; NRXN3; NSA2; NSDI NSDHL: NSF; NSFLIC; NSGI; NSMAF; NSMCE2; NSMF; NSRPI; NSUN2; NSUN3; NSUN5; NSUN7; NT5CIB; NT5CIB-RDHI4; NT5C2; NT5C3A; NT5C; NT5DCI; NT5DC3; NT5E; NT5M; NTANI; NTF3; NTF4; NTHLI; NTM; NTNI; NTN4; NTNGI NTNG2; 0 NTPCR; NTRKI; NTRK2; NTRK3; NTS; NTSRI; NTSR2; NUAKI; NUAK2; NUBI; NUBPI; NUBP2; NUBPL; NUCBI; NUCB2; NUCKSI; NUDCD;
[0446] NUDCD3; NUDC; NUDTIO; NUDTII; NUDTI5; NUDTI9; NUDTI: NUDT2I; NUDT2; NUDT3; NUDTB; NUDT7; NUF2; NUFIPI; NUFIP2; NUGGC;
[0447] NUMAI; NUMB; NUMBU NUPI53; NUPI55; NUP205; NUP2IO; NUP2I4; NUP35; NUP37; NUP43; NUP50; NUPB2; NUP85; NUP88; NUP93;
[0448] NUPB8; NUPL2; NUPRI; NUSI; NUSAPI; NUTF2; NUTMI; NUTM2A; NUTM2B; NVL; NWDI; NXFI; NXF2B; NXF3; NXF5; NXN; NXNL1; NXNL2;
[0449] NXPEI; NXPE2; NXPE4; NXPHI: NXPH2; NXTI: NXT2; NYAP2; NYX; OARDI; OASI; OAS2; OAS3; OASL; OAT; OAZI; OAZ2; OBFCI; OBP2A; 5 OBSCN; OBSLI; OC90; OCA2; OCIADI; OCIAD2; OCLM; OCLN; OCM2; OCM; OCRL; ODAM; ODCI; ODFI; ODF3B; ODF4; OFCCt OFDI; OGDH; OGDHL; OGFDDI; OGFR; OGGI; OGN; OGT; OIPS; OIT3; OLAI; OLFMI; OLFM2; OLFM4; OLFMLZB; OLI6I; OLIG2; OL1G3: OLRI; OMD; OMG;
[0450] OMP; ONECUTI; ONECUT2; OPAI; OPA3; OPCML; OPHNI; OPNILW; OPNIMW2; OPNISW; OPN3; OPN4; OPN5; OPRKI; OPRU; OPRMI; OPTC;
[0451] OPTN; ORIDA2; ORIOA4; ORIOCI; ORIOJI; ORIOJ3; ORIOJ5; ORIOKI; ORIOK2; ORIOR2; ORIOT2; ORIOXI; ORIOZI; ORIIAI; ORI2D2;
[0452] ORI2D3; ORI3C3; OR13C4; ORI3FI: ORI3GI; ORI3JI; ORI4JI; ORIAI; ORICI; ORID2; ORIEI; ORIE2; ORIJ2; ORIKI; ORIL8; ORIMI: ORINI; ORIN2; OR2A25; OR2AGI; OR2AK2; OR2AT4; OR2B2; OR2B3; OR2BB; OR2CI; OR2F2; OR2G2; OR2G3; OR2H2; OR2J2; OR2J3; OR2L2;
[0453] OR2M3; OR2M4; OR2M7; OR2S2; OR2TID; OR2TI2; OR2TI; OR2T2; OR2T33; OR2T4; OR2T5; OR2W1; ORZYI: OR2ZI; OR3AI; OR4AI5;
[0454] OR4CI2; OR4CI3; OR4CB; OR4DI0; OR4KI3; OR4P4; OR4S2; OR5IA2; OR5IA7; OR5IEI; OR5IE2; OR5IF2; OR5IVI; OR52B2: OR52B4;
[0455] OR52DI; OR52EG; OR52II; OR52I2; OR52KI; OR52K2; OR5ZMI: OR5DI8; OR5H2; OR5HB; OR5KI; OR5K2; OR5VI; ORGBI; OR6B2; ORBCI:
[0456] ORBFI; ORGK2; ORGK3; ORBK6; ORBNI; OR6N2; ORBXI ORGYI; OR7CI; OR7D2; OR7EZ4; OR8SI: ORBK2; OR9Q2; ORAM; ORAI3; ORAOVI; ORC3; ORC4; ORC5; ORCB; ORMI: ORM2; ORMDL3: OS3; OSBP2; OSBP; OSBPLID; OSBPLII; OSBPLIA; OSBPL2; OSBPL3;
[0457] OSBPL5; OSBPLB; OSBPL8; OSBPLB; OSCAR; OSERI: OSGEP; OSGINI; OSM; OSMR; OSRI; OSR2; OSTFI; OSTMI; OTC; OTDA; OTOF;
[0458] OTDG; OTDGL; OTOLI; OTOPI; OTOR; OTP; OTUBI; OTUDI; OTUD4; OTUD7A; OTUD7B; OTULIN; OTXI; OTX2; OVCA2; OVDLI; OVDL2; OXAIL;
[0459] OXCTI; OXERI; OXGRI; OXRI; OXSRI; OXT; OXTR; P2RXI; P2RX2; P2RX3; P2RX4; P2RX5: P2RXG; P2RX7; P2RYII; P2RYI2; P2RYI3;
[0460] P2RYI4; P2RYI; P2RY2; P2RY4; P2RYB; P2RY8; P3H2; P3H3; P3H4; P4HAI; P4HA2; P4HB; P4HTM; PA2G4; PABPCI; PA8PC3; 15 PABPC4L; PABPNI; PACRG; PACSI; PACS2; PACSINI; PACSIN2; PADI4; PAEP; PAFI; PAFAHIBI; PAFAHIB2; PAFAH2; PAGI PAGEI; PAGE4;
[0461] PAGE5; PAGRI; PAH; PAICS; PAIPI; PAIP2; PAKI; PAKIIPI; PAK2; PAK3; PAK4; PAKB; PAK7; PALB2; PALDI; PALLD; PALM2-AKAP2;
[0462] PAMIB; PAM; PAMRI; PAN2; PANS; PANKI; PANK2; PANXI; PANX2; PAOX; PAP07; PAPL; PAPOLA; PAPOLG; PAPPA2; PAPPA; PAPSSI;
[0463] PAPSS2; PAOR3; PAQR5; PADR7; PARD3B; PARD3; PAROBA; PARDGB; PARG; PARK2; PARL; PARMI; PARN; PARPI2; PARPI4; PARPI5;
[0464] PARPI; PARP2; PARP3; PARP4; PARPB; PARPB; PARPBP; PARS2; PARVA; PARVB; PARVG; PASDI; PASK; PATEI; PATZI; PAWR; PAXI:D PAX2: PAX3; PAX4; PAX5; PAXB; PAX8; PAXB; PAXIPI; PBK; PBLD; PBOVI PBRMI; PBXI; PBX2; PBX3; PBX4; PCBDI PCBD2; PCBPI;
[0465] PCBP2; PCBP3; PCBP4; PCCA; PCCB; PCDHID; PCDHIIX; PCDHIIY; PCOHI5; PCDHI7; PCDHI8; PCDHI9; PCDHI: PCDH2D; PCDH7;
[0466] PCDH8; PCDHB; PCDHAI; PCDHA4; PCDHAB; PCDHBI: PCDHB2; PCDHB3; PCDHB8; PCDHGAII; PCDHGA3; PCDHGB4; PCDHGBB;
[0467] PCDHGC3; PCEDIB; PCFII; PCGFI: PCGF2; PCGF3; PCGFB; PC; PCID2; PCKI; PCK2; PCLO; PCMI: PCMTI PCMTDI; PCNA; PCNT; PCNXL2;
[0468] PCNXL4; PCOLCE2; PCDLCE; PCP2; PCP4; PCSKI; PCSKIN; PCSK2; PCSK4; PCSK5; PCSKB; PCSK7; PCTP; PCYTIA; PCYTIB; PDAPI; 5 POCDIO; PDCDI; PDCDILG2; PDCD2; PDCD4; PDCD5; PDCD6; PDCOGIP; PDCD7; PDC; PDCL2; PDCL3; PDEIDA; PDEIIA; PDEI2; PDEIA;
[0469] PDEIB; PDEIC; PDE2A; PDE3A; PDE3B; PDE4A; PDE4D; PDE5A; PDEBA; PDEBB; PDEGC; PDEBD; PDEGG; PDEGH; PDE7A; PDE7B: PDE8A;
[0470] PDE8B; PDE9A; PDF; PDGFA; POGFB; POGFC; PDGFD; PDGFRA; PDGFRB; PDGFRL; PDHAI; PDHB; PDHX; PDIA2; PDIA3; PDIA4; PDIA5;
[0471] PDIAB; PDKI; PDK2; PDK3; PDK4; PDLIMI; PDLIM2; PDLIM3; PDLIM4; PDLIM5; PDLIM7; PDPI PDP2; PDPKI; PDPR; PDRGI; PDS5A;
[0472] PDS5B; PDSSI; PDSS2; PDXI; PDXDCI; PDXK; PDXP; PDYN; PDZD2; PDZD4; PDZD7; PDZD8: PDZKI; PDZRN3; PDZRN4; PEAI5; PEAKI; PEARI; PEBPI; PEBP4; PECAMI; PECR; PEGID; PEG3; PELII PELI2; PELPI; PEMT; PENK; PEPD; PERI; PER2; PER3; PERM!: PERP; PESI;
[0473] PETIOD; PETII7; PEXIIA; PEXI2; PEXI3; PEXI4; PEXIG; PEXI9; PEXI; PEX2B; PEX2; PEX3; PEX5; PEX5L; PEXB; PEX7; PF4; PF4VI; PFDN4;
[0474] PFDN5; PFDNB; PFKFBI; PFKFB2; PFKFB3; PFKFB4; PFKL; PFKM; PFKP; PFNI; PFN2; PGA3; PGA4; PGA5; PGA I; PGAM2; PGAM4; PGAPI;
[0475] PGAP2; PGAP3; PGBDI; PGBD5; PGC; PGD; PGF; PGGTIB; PGKI; PGK2; PGLS; PGLYRPI; PGLYRP2; PGLYRP3; PGLYRP4; PGM3; PGPEPI;
[0476] PGP; PGR; PGRMCI; PGRMC2; PHACTRI; PHACTR2; PHACTR3; PHB2; PHB; PHCI; PHC2; PHC3; PHEX; PHFIO; PHFII; PHFI2; PHFI9; PHFI; 5 PHF20; PHF2IA; PHF23; PHF2; PHF3; PHF5A; PHFB; PHF8; PHGDH; PHIP; PHKAI; PHKA2; PHKB; PHKGI; PHKG2; PHLDAI; PHLDA2; PHLDA3; PHLDBI PHLPPI; PHLPP2; PHOX2A; PHOX2B; PHPTI; PHRFI; PHTFf; PHTF2; PHYH; PHYHIP; PHYKPL; PII5; PUB; PI3; PI4 2A;
[0477] P14 2B; PI4KA; P14 B; PIASt; PIAS2; PIAS4; PIBFI; PICALM; PICKI; PIDI; PIDDI; PIEZDI; PIEZD2; PIFI; FIFO; PIGA: PIGF; PIGG; PIGL;
[0478] PIGM; PIGN; PIGD; PIGP; PIGB; PIGR; PIGT; PIGU; PIGW: PIGY; PIHIDI; PIK3API; PIK3C2A; PI 3C2B; PIK3C2G; PI 3C3; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIK3IPI; PIK3R1: PI 3R2; PIK3R3; PIK3R4; PI 3R5; PIKFYVE; PILRA; PIMI; PIM2; PIM3; PINI PIN4; PINXI PIP4K2A; PIP4K2B; PIP4K2C; PIP5KIA; PIP5 IB; PIP5 IC; PIP5KLI; PIP; PIPOX; PIR; PISD; PITPNA; PITPNMI; PITPNM3: PITRMI; PITXl; PITX2;
[0479] PITX3; PIWILI; PIWIL2; PIWIL3; PIWIL4; PJAI; PJA2; P DI; PKDILI; PKDIL2; PKDIL3; PKD2; PKD2LI; PKDCC; PKDREJ; PKHDI; PKIA; PKIB;
[0480] PKLR; PKM; PKMYTI; PKNI; PKN2; PKN3; PKNOXI; PKNOX2; PKPI; PKP2; PKP3; PKP4; PLA1A; PLA2GIO; PLA2GI2A; PLA2GI2B; PLA2GI5;
[0481] PLA2GIB; PLA2GIB; PLA2G3; PLA2G4A; PLA2G4B; PLA2G4C; PLA2G4D: PLA2G5; PLA2 GB; PLA2G7; PLA2RI; PLAA; PLACI; PLAC8;
[0482] PLAGI; PLAGLI; PLAGL2; PLAT; PLAU; PLAUR; PLBh PLBDI; PLCBI; PLCB2; PLCB3; PLCB4; PLCDI: PLCD3; PLCD4; PLCEI; PLCGI; PLCG2; PLCHI; PLCLI; PLCL2; PLCXD2; PLCXD3; PLCZI; PLDI; PLD2; PLD3; PLD4; PLD5; PLEC; PLEK2; PLEKHAI; PLEKHA2; PLEKHA5; PLEKHAB;
[0483] PLEKHA7; PLEKHBI; PLEKHDI; PLEKHFI; PLEKHF2; PLEKHGI; PLEKHG2; PLEKHG3; PLEKHG4; PLEKHGB; PLEKHH2; PLEKHMI; PLEKHDI;
[0484] PLEKH02; PLEK; PLG; PLGLB2; PLINI; PLIN2; PLIN3; PLIN4; PLIN5; PLKi: PLK2; PLK4; PLK5; PLLP; PLN; PLOD2; PLPI; PLP2; PLRGI;
[0485] PLSI; PLS3; PLSCRI; PLSCR3; PLSCR4; PLSCR5; PLTP; PLVAP; PLXDCI; PLXDC2; PLXNAI; PLXNA2; PLXNA3; PLXNA4; PLXNB1; PLXNB3;
[0486] PLXNCI; PLXNDI; PM2DDI; PMAIPI PMCH; PMEL; PMEPAI; PMFI-BGLAP; PMFI; PML; PMMI; PMM2; PMP22; PMPCA; PMPCB; PMSI; PMS2; PMVK; PNCK; PNKD; PNKP; PNLDCI; PNLIP; PNLIPRP2; PNMAI; PNMA2; PNMT; PNN; PNDI; PNOC; PNP; PNPLA1; PNPLA2; PNPLA3;
[0487] PNPLA4; PNPLA5; PNPLAG; PNPLA8; PNPO; PNPTI; PNRCf; POCIA; POCIB; POC5; PDDXL; POFIB; POFUTI; POFUT2; POGK; POGLUTI;
[0488] POLAI; POLA2; POLB; PDLOI; POLD2; POLD3; PDLD4; POLDIP3; POLE2; POLE3; POLE4; POLE; POLG2; POLG; POLH; POLL POLK; POLL;
[0489] POLM; POLN; POLO; POLRIA; POLRIB; POLRIC; POLRID; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2G; POLR2H;
[0490] POLR2J; POLR2K; POLR2M; POLR3A; POLR3B; POLR3E; POLR3K; POLRMT; POMI2I; POMC; POMGNTI; POMGNT2; POMK; POMP; POMTI; POMT2; POMZP3; PONI PON2; PONS; POP1; POP4; POPDC3; PORCN; POR; POSTN; POTI; POTED; POTEF; POTEG; POTEH; POTEM;
[0491] POUIFI; POO2AFI; POU2FI; POU2F2; POU2F3; POU3F2; POU3F3; POU3F4; POU4FI; POU4F2; P004F3; POU5FIB; POU5FI: POUBFI:
[0492] POOBF2; PPAI; PPA2; PPAP2A; PPAP2C; PPAPDCIB; PPAPDC2; PPAPDC3; PPARA; PPARD; PPARGCIA; PPARGCIB; PPARG; PPAT; PPBP;
[0493] PPCDC; PPEFI; PPEF2; PPFIAI: PPFIA2; PPFIA4; PPFIBPI PPFIBP2; PPIA; PPIB; PPIC; PPID; PPIF; PPIG; PPILI; PPIL2; PPIL3; PPIP5I;
[0494] PPL; PPMIA; PPMIB; PPMID; PPMIE; PPMIF; PPMIG; PPMIH; PPMIK; PPMIL; PPMIM; PPMEI; PPOX; PPPICA; PPPICC; PPPIRIO; PPPIRII; PPPIRI2A; PPPIRI2B; PPPIRI2C; PPPIRI3B; PPPIRI3L; PPPIRI4A; PPPIRI4B; PPPIRI4C; PPPIRI5A; PPPIRI5B; PPPIRI7; PPPIRI8;
[0495] PPPIRIA; PPPIRIB; PPPIR2; PPPIR3A; PPPIR3B; PPPIR3C; PPPIR42; PPPIR7; PPPIR9A; PPP2CA; PPP2CB; PPP2RIA: PPP2RIB;
[0496] PPP2R2A; PPP2R2B; PPP2R2C; PPP2R3A; PPP2R3B; PPP2R4; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E; PPP3CA;
[0497] PPP3CB; PPP3CC; PPP3RI; PPP3R2; PPP4C; PPP4RI; PPP5C; PPPBC; PPPBR2; PPPBR3; PPRCI; PPT2; PPY; PQBPI: POLC3; PRACI;
[0498] PRAC2; PRADCI; PRAF2; PRAMI; PRAME; PRAPI; PRBI; PRB2; PRB3; PRB4; PRCI; PRCC; PRCD; FRCP; PRDMIO; PRDMII; PRDMI3; PRDMI4; PRDMI; PRDM4; PRDM5; PRDMB; PRDM7; PRDM8; PRDM9; PROX2; PRDX3; PRDX4; PRDX5; PRDXG; PREB; PRELP; PREP;
[0499] PREPL; PREXI; PREX2; PRFI; PRG2; PRG4; PRHI; PRH2; PRICKLEI; PRICKLE2; PRICKLE4; PRIM1; PRIMAL PRIMPOL; PR AAI; PRKABI;
[0500] PRKACA; PRKACB; PRKACG; PRKABI: PRKAG2; PRKAG3; PRKARIA; PRKARIB; PRKAR2A; PRKAR2B; PRKCA; PRKCB; PRKCDBP; PRKCD;
[0501] PRKCE; PRKCG; PRKCH; PRKCI; PRKCQ; PRKCSH; PRKCZ; PRKDI; PRKD3; PRKOC; PRKGI; PRKG2; PRKRA; PRKRIR; PRKX; PRLH; PRL;
[0502] PRLHR; PRLR; PRMI: PRM2; PRM3; PRMTI; PRMT2; PRMT3; PRMT5; PRMT8; PRND; PRNP; PROC; PROCR; PRODH; PROK2; PRBKRI: PROKR2; PROLI; PROMI; PROM2; PROPL PROSI; PROSERI; PRBXI: PROZ; PRPFI9; PRPF3I: PRPF3BB; PRPF3; PRPF40A; PRPF4B; PRPF4; PRPFFJ; PRPF8; PRPH2; PRPH; PRPSI; PRPSILI; PRPS2; PRPSAPI; PRPSAP2; PRRII; PRRI3; PRRI5; PRRIB; PRR34; PRR3;
[0503] PRR5; PRR9; PRRCI PRRC2A; PRRC2C; PRRG4; PRRTI; PRRT2; PRRXI; PRRX2; PRSSI2; PRSSI6; PRSSI: PRSS2I; PRSS22; PRSS23;
[0504] PRSS27; PRSS2; PRSS33; PRSS35; PRSS3; PRSS5D; PRSS53; PRSS55; PRSS57; PRSS58; PRSS8; PRTFDCI; PRTG; P TN3; PRUNE2;
[0505] PRUNE; PRX; PRY; PSAP; PSATI; PSCA; PSD3; PSD4; PSD; PSENI PSEN2; PSENEN; PSBI; PSB2; PSG5; PSGB; PSG8; PSG9; PSIPI; 5 PSKHI; PSMAI; PSMA2; PSMA3; PSMA4; PSMAB; PSMA7; PSMBID; PSMBI; PSMB4; PSMB5; PSMBB; PSMB7; PSMBB; PSMB9; PSMCI;
[0506] PSMC2; PSMC3; PSMC3IP; PSMC4; PSMC5; PSMCB; PSMDIO; PSMDI2; PSMDI3; PSMDI4; PSMDI: PSMD2: PSMD3; PSMD4; PSMDB;
[0507] PSMD7; PSMD8; PSMDB; PSMEI; PSME2; PSME3; PSME4; PSMFI; PSMBI; PSMG2; PSMG3; PSORSIGI; PSORSIC2; PSPCI; PSPH; PSPN;
[0508] PSTPIPI; PSTPIP2; PTBPI; PTBP2; PTCDI; PTCHI PTCHDI; PTCHD4; PTCRA; PTDSSI; PTEN; PTER; PTFIA; PTGDR2; PTGDR; PTGDS;
[0509] PTGERI; PTGER2; PTGER3; PTGER4; PTGES2; PTGES3; PTGES; PTGIR; PTGIS; PTG i; PTGSI; PTGS2; PTHIR; PTH2; PTH2R; PTH; PTHLH; ID PTK2B; PTK2; PTKB; PTK7; PTMA; PTMS; PTN; PTDVI; PTP4AI; PTP4A3; PTPMTI; PTPNII; PTPNI2; PTPNI3; PTPNI4; PTPNI8; PTPNI;
[0510] PTPN2I; PTPN22; PTPN23; PTPN2; PTPN3; PTPN4; PTPN5; PTPNB; PTPN7; PTPN9; PTPRA; PTPRB; PTPRCAP; PTPRD; PTPRE; PTPRG;
[0511] PTPRH; PTPRJ; PTPRK; PTPRM; PTPRN2; PTPRN; PTPRD; PTPRfl; PTPRR; PTPRS; PTPRT; PTPRZI; PTRF; PTRHI; PTRH2; PTRHDI; PTS;
[0512] PTTGI: PTTGIIP; PHG2; PTX3; PUFBD; PDM2; PURA; PURB; PUSID; PUS1; PVALB; PVR; PVRLI; PVRL2; PVRL3; PVRL4; PWP2; PWWP2B;
[0513] PXDN; PXDNL; PXK; PXMP2; PXN; PXTI; PYCARD; PYCRI; PYDCI; PYDC2; PYGB; PYGL; PYGM; PYGDI; PYGD2; PYHINI PYROXDI; PYY; PZP; OARS; DDPR; OKI; QPCT; QPCTL; OPRT; QRFP; ORFPR; ORSLI; OSDXI; QSOX2; QTRTI; R3HCCI; R3HCCIL; R3HDMI; R3HDML;
[0514] RABIIA; RABIIB; RABIIFIPI; RABIIFIP2; RABIIFIP3; RABIIFIP4; RABIIFIP5; RABI2; RABI4; RABI5; RABI8; RABIA; RABIB; RAB20; RAB2I;
[0515] RAB22A; RAB23; RAB24; RAB25; RAB27A; RAB27B; RAB28; RAB2B; RAB2A; RAB3I; RAB32; RAB33B; RAB34; RAB35; RAB3B; RAB37;
[0516] RAB38; RAB39A; RAB39B; RAB3A; RA83D; RAB3GAPI; RAB3GAP2; RAB3ILI; RAB3IP; RAB40AL; RAB4DB; RAB4DC; RAB4A; RAB4B;
[0517] RAB5A; RAB5B; RAB5C; RABGA; RABBB; RABBC; RAB7A; RAB8A; RAB8B; RAB9A; RABACI; RABEPI; RABEP2; RABEPK; RABGAPIL; RABGEFI; RABIF; RABLB; RACI; RAC2; RAC3; RACGAPI; RADI7; RADI8; RADI; RAD2I; RAD2ILI; RAD23A; RAD23B; RAD50; RAD5IAPI:
[0518] RAD5IB; RAD5IC; RAD5ID; RA05I: RAD52; RAD54B; RAD9A; RAD9B; RAEI; RAETIE; RAETIL; RAFI; RAGI; RAG2; RAII4; RAIL RAI2; RALA;
[0519] RALB; RALBPI; RALGAPAI: RALGAPA2; RALGAPB; RALGDS; RALGPSL RALY; RALYL; RAMP RAMP2; RAMP3; RANBPIO; RANBPI7;
[0520] RANBPI; RANBP2; RANBP3; RANBP3L; RANBPB; RANBP9; RANGAP RANGRF; RAN; RAPIB; RAPIGAP2; RAPIGDSI; RAP2A; RAP2B;
[0521] RAPGEFI; RAPGEF2; RAPGEF3; RAPGEF4; RAPGEF5; RAPH RAPSN; RARA; RARB; RARG; RARRESL RARRES2; RARRES3; RARS2; RARS; 5 RASAI; RASA2; RASALL RASAL2; RASDL RASD2; RASEF; RASGEFIA; RASGEFIC; RASBRFI; RASGRF2; RASGRPI; RASGRP2; RASGRP3;
[0522] RASGRP4; RASIPI; RASLIOA; RASLIDB; RASLIIA; RASLIIB; RASLI2; RASSF RASSF2; RASSF3; RASSF4; RASSF5; RASSFB; RASSF7;
[0523] RASSF8; RAX2; RAX; RBICCI; RBI; RBAK; RBBP5; RBBPB; RBBP7; RBBP8; RBBP9; RBCKL RBFBXI; RBFDX2; RBFDX3; RBLI; RBL2;
[0524] RBMID; RBMI2; RBMI4; RBMI4-RBM4; RBMI5; RBMI7; RBM2D; RBM25; RBM2B; RBM27; RBM28; RBM38; RBM39; RBM3; RBM45;
[0525] RBM4B; RBM47; RBM4; RBM5; RBMB; RBM7; RBMS RBMS2; RBMS3; RBMX2; RBMX; RBMXL2; RBMYIAL RBPI; RBP2; RBP3; RBP4; RBPJ; RBPMS2; RBSN; RBXI; RC3HI; RCANI; RCAN2; RCBTBI: RCBTB2; RCHYI; RCLL RCN RCN2; RCBRI; RCSDL RCVRN; RD3; RDHIO;
[0526] RDHII; RDHI2; RDHI4; RDHIB; RDH5; RDH8; RD I; RDX; REC8; RECK; RECOL5; RECOL; REEPI; REEP2; REEP3; REEP5; REEPB; REGIA;
[0527] REGIB; REG3A; RELA; RELB; REL; RELN; REM RENBP; REN; REPSL REPS2; RERG; RERGL; REST; RET; RETN; RETNLB; RETSAT: REVI;
[0528] REV3L; REXDI; REXD2; REX04; RFCI; RFC2; RFC3; RFC4; RFC5; RFFL; RFK; RFPL RFTI; RFTNL RFTN2; RFWD2; RFWD3; RFX RFX2;
[0529] RFX3; RFX4; RFX5; RFXG; RFX8; RFXANK; RFXAP; RGCC; RBLI RGL2; RGL4; RGMA; RGMB; RGN; RGPD2; RGR; RGSID; RGSII; RGSI2; 5 RGSI3; RGSI4; RGSIB; RGSI7; RGSI8; RGSI9; RGSI; RGS20; RGS2I; RGS22; RGS2; RGS3; RGS4; RGS5; RGSB; RGS7BP; RGS7; RGS8; RBS9BP; RBS9; RGSLI; RHAB; RHBD02; RHBDD3; RHBDFI RHBDF2; RHBDLI RHBDL2; RHCE; RHCG; RHEB; RHEBLI RHNDI: RHOB;
[0530] RHBBTBI; RHDBTB2; RH08TB3; RHOD; RHDF; RHOG; RHDH; RHD; RHDJ; RHD11: RHDTI; RHDU; RHOV; RHOXFI RHDXF2: HPNI RHPN2;
[0531] RIBC2; RICI; RIC3: RICTOR; RIFI; RILP: RILPLI RIMBP2; RIMBP3C: RIMSI: RIMS2; RIMS4: RINI; RIN2; RIN3; INB1; RINTI; RIDKI; RIOK2;
[0532] RI0K3; RIP I; RIP 2; RIP 3; RIP 4: RIPPLY2; RITI; RIT2: RITAI RLBPI RLF; RUM; RLNI RLN2; RLN3; RMDNI; R DN2; RMDN3; RMII; RMI2; RHNDI; RNASEII; RNASEI2; RNASEI3: RNASEI: RNASE2; RNASE3; RNASE4; RNASEB; RNASE7; RNASE8; RNASEB; RNASEHI;
[0533] RNASEH2A; RNASEH2B; RNASEH2C; RNASEK; RNASEL; RNASET2; RNDI; RND3; RNFI03-CHMP3; RNFI03; RNFIII; NF112: RNFII4;
[0534] RNFI23; RNFI25; RNFI28; RNFI30; RNFI35: RNFI38; RNFI39; RNFI44A; RNFI44B; RNFI4B; RNFI49; RNFI4; RNFI50; RNFI52; RNFI57;
[0535] RNFIG7; RNFIB8; RNFI7D; RNFI80; RNFI82: RNFI9A; RNF2D7; RNF20; RNF2I3; RNF2I4; RNF2IB; RNF24; RNF2; RNF3I: RNF34; RNF39;
[0536] RNF40; RNF4I; RNF43; RNF44; RNF4; RNF5; RNFB; RNF7; RNFS; RNGTT; RNHI; RNLS; RNMT; RNPEP; RNPEPLI; RNPSI; RDBOI; ROBD2; ROB03; ROB04; ROCKI: ROC 2; ROGDI; ROMI; RDPNIB; RDPNI; ROPNIL: RORI; ROR2; RORA; RORB; RDRC; RDSI; RPI RPILI; RP2; RP9;
[0537] RPAI; RPA2; RPA3; RPA4; RPAIN; RPAPI; RPE; RPGR; RPGRIPI; RPGRIPIL; RPH3A; RPH3AL: RPIA; RPLIOA; RPLIO; RPLIDL; RPLI2;
[0538] RPLI3; RPLI4; RPLI5; RPLI7; RPLI8; RPLI9; RPL2I; RPL23A: RPL23: RPL24; RPL27A; RPL29; RPL3D; RPL3I; RPL34;
[0539] RPL35; RPL3BA; RPL3BAL; RPL37A; RPL38; RPL39; RPL39L; RPL3; RPL4I; RPL4; RPLB; RPL7A; RPL7; RPLPD; RPLPI: RPNI; RPN2;
[0540] RPPI4; RPP2I; RPP25; RPP38; RPP4D; RPRDIA; RPRDIB; RPRD2; RPRM; RPSIO; RPSI4; RPSI5A; RPSIB; RPSI8; RPSI9BPI; RPS20; RPS24; RPS27A; RPS27; RPS27L; RPS29; RPS2; RPS3A; RPS3; RPS4X; RPS4YI RPSBKA2; RPSBKA3; RPSBKA4; RPSBKA5; RPSG AG;
[0541] RPSBKBI; RPSBKB2; RPS9; RPSA; RPTOR; RDCDI; RRAD; RRAGA: RRAS2: RRAS; RRBPl; RREBI; RRH; RRMI; RRM2B; RRN2; RRN3;
[0542] RRNADI; RRPIB; RRP1; RRP9; RRSI RSI RSAD2; RSFI: RSLIDI; RSL24DI; RSPHI: RSPH4A; RSPH9; RSPO2; RSPQ3: RSPO4; RSRCI;
[0543] RSRC2; RSRPI; RSUI; RTCB; RTELI; RTKN2; RTKN; RTLI: RTNI RTN2; RTN3; RTN4: RTN4IPI: RTN4R: RTP3; RTP4; RTTN; RUFYI; RUFY3; RUNDC3B; RUNXI; RUNXITI RUNX2; RUNX3: RUVBLI; RUVBL2; RXFPI: RXFP2; RXFP3; RXRA; RXRB; RXRG; RYBP; RYK: RYRI; RYR2; RYR3; SIDDAIO; SIODAII; SIODAI2: SIDOAI3; SIDOAI4; SIOOAIB; SIODAI; SIOOA2; SIDOA3; SIODA4: SIOOA5; SIODAB; SIOOA7A; SIOA7;
[0544] SIDDA8; SIODAB; SIOOB; SIDOP: SIDOZ; SIPR2; SIPR3; SIPR4; SIPR5; SAAI: SAA2: SAA4; SAALI; SAC3DI; SACMIL; SACS; SAEI; SAFB2;
[0545] SAFB; SAGEI; SAG; SALLI; SALL2; SALL3; SALL4; SAMDI4; SAMDI; SAMD4A; SAMD5; SAMD9; SAMD9L; SAMHDI; SAMM5D; SAMSNI;
[0546] SAP30BP; SAP3DL; SAPCDf; SAPCD2; SARIA; SARIB; SARDH; SARMI; SARNP; SARS2; SARTI; SART3; SASHI; SASH3; SATI; SAT2;
[0547] SATBI; SATB2; SATLI; SAVI SBDS; SBFI: SBF2; SBNOI; SBND2; SBSN; SC50; SCAFII; SCAFI; SCAF4; SCAF8; SCAI; SCAMP2; SCAMP5; SCAPER; SCAP; SCARA3; SCARAB; SCARBI; SCARB2; SCARF2; SCCPDH; SCD5; SCO; SCFDI; SCFD2; SCG2; SCG3; SCG5; SCGBIAI;
[0548] SCGBIDI; SCGBID2; SCGB2AI: SCGB2A2; SCGB2B2; SCGB3AI; SCGB3A2; SCGN; SCHIPI; SGIN; SCLTI; SCLY; SCML2; SCML4; SCNIBA;
[0549] SCNIIA; SGNIA; SCNIB; SCN2A; SCN2B; SCN3A; SCN3B; SCN4A; SCN4B; SCN5A; SCN7A; SCN8A; SCN9A; SCNMI; SCNN1A; SCNNIB;
[0550] SCNNID; SCNNIG; SCDI; SC02; SCPZDI SCPEPI SCRIB; SCRNI; SCT; SCTR; SCUBEI: SCUBE2; SCUBE3; SCYLI; SCYL3; SDCI; SDC2;
[0551] SDC3; SDC4; SDCBP2; SDCBP; SDCCAG3; SDCCAG8; SDF2; SDF2LI; SDF4; SDHAFI; SDHAF2; SDHAF4; SDHA; SDHC; SDHD; SDKI; SDK2; SDPR; SDR42EI; SDR9C7; SOS; SECIIA; SECIIC; SECI3; SECI4LI; SECI4L2; SECI4L3; SECIBB; SEC23A; SEC23B; SEC23IP;
[0552] SEC24A; SEC24B; SEC24C; SEC3IA; SECBIAI; SECBIB; SECB2; SECB3; SECISBP2; SECISBP2L; SECTMI; SELIL; SELE; SELENBPl; SELL;
[0553] SELP; SELPLG; SEMA3A; SEMA3B; SEMA3C; SEMA3D; SEMA3E; SEMA3F; SEMA3G; SEMA4A; SEMA4B; SEMA4D; SEMA4F; SEMA4G;
[0554] SEMA5A; SEMA5B; SEMABA; SEMABB; SEMABD; SEMA7A; SEMGI; SEMG2; SENPI; SENP2; SENP3; SENP5; SENPB; SENP8: SEPHSI;
[0555] SEPSECS; SERACI; SERFIA; SERGEF; SERINCI SERINC3; SERINC5; SERPI; SERP2; SERPINAIO; SERPINAII; SERPINAI2; SERPINAI: SERPINA3; SERPINA4; SERPINA5; SERPINAB; SERPINA7; SERPINA9; SERPINBIO; SERPINBI3; SERPINBI; SERPINB2; SERPINB3; SERPINB4; SERPINB5; SERPINBG; SERPINB7; SERPINB8; SERPINB9; SE PINCI; SERPINDI; SERPINEI; SERPINE2; SERPINE3; SERPINFI
[0556] SERPINF2; SERPINGI; SERPINHI; SERPINII; SERPINI2; SERTADI SERTA02; SESNI; SESN3; SETBPI; SETDIA; SETDIB; SETD2; SETD3;
[0557] SETD5; SETO7; SETD8; SETDB2; SET; SETMAR; SETX; SEZB; SEZBL2; SEZGL; SFI SF3AI; SF3BI; SF3B2; SF3BB; SFII; SFMBTI; SFMBT2;
[0558] SFRI; SFRPI; SFRP2; SFRP4; SFRP5; SFSWAP; SFT2D2; SFT203; SFTA2; SFTA3; SFTPAI; SFTPA2; SFTPB; SRPC; SFTPD; SFXNI; SFXN2; SFXN4; SGCA; SGCB; SGCD; SGCE; SGCG; SGCZ; SGIPI; SGKi; SGK223; SGK2; SGK3; SGMSI SGMS2; SGDLI; SGPLI; SGPPI; SGPP2;
[0559] SGSH; SGSM2; SGSM3; SGTA; SH2BI; SH2B2; SH2B3; SH2DIA; SH202A; SH2D3A; SH2D3C; SH2D4A; SH2D4B; SH3BGR; SH3BGRL2;
[0560] SH3BGRL; SH3BPI; SH3BP2; SH3BP4; SH3BP5; SH3DI9; SH3GLI; SH3GL2; SH3GL3; SH3 BPI; SH3PXD2A; SH3PXD2B; SH3RFI;
[0561] SH3RF3; SH3TC2; SH3YLI; SHANKI; SHANK2; SHANK3; SHARPIN; SHBG; SHB; SHCI; SHC2; SHC3; SHC4; SHCBPI; SHE; SHFMI; SHH;
[0562] SHISA2; SHISA3; SHISAB; SHISA9; SHMTI; SHMT2; SHOC2; SHDX2; SHDX; SHPK; SHPRH; SHQI; SHRDDM2; SHRDDM3; SHRODM4; SIAE; SIAHI; SIAH2; SIDTI; SIGIRR; SIGLECII; SIGLECI4; SIGLECI; SIGLEC5; SIGLEC7; SIGLECB; SIGLEC9; SIGMARI; SI; SIKI: SIK2; SI3;
[0563] Sill; SIMI; SIM2; SIN3A; SIN3B; SIPAI; SIPAIL2; SIPAIL3; SIRPA; SIRPBI; SIRPG; SIRTI; SIRT2; SIRT3; SIRT4; SIRT5; SIRTG; SIRT7; SITI;
[0564] SIVAI; SIX1; SIX2; SIX3; SIX4; SIX5; SIXG; SKAI; SKA2; SKAPI: SKAP2; SIL; SIV2L2; SIV2L; SKORI; SOR2; SKPI; SKP2; SLA2; SLA;
[0565] SLAIN2; SLAMFI; SLAMFB; SLAMF7; SLAMF8; SLBP; SLCIDAI; SLCIQA2; SLCIDAG; SLCIDA7; SLCIIAI; SLCIIA2; SLCI2AI; SLCI2A2;
[0566] SLCI2A3; SLCI2A4; SLCI2A5; SLCI2AB; SLCI2A7; SLCI2A8; SLCI2A9; SLCI3AI; SLCI3A2; SLCI3A3; SLCI3A5; SLCI4AI; SLCI4A2; SLCI5A1; SLCI5A2; SLCI5A4; SLCIBAIO; SLCIBAII; SLCIBAI2; SLCIBAI3; SLCIBAI; SLCIBA2; SLCIBA3; SLCIBAB; SLCIBA7; SLCIBA8;
[0567] SLCIBA9; SLCI7AI; SLCI7A2; SLCI7A3; SLCI7A4; SLCI7A5; SLCI7AB; SLCI7A7; SLCI7A8; SLCIBAI; SLCI8A2; SLCI8A3; SLCI9AI:
[0568] SLCI9A2; SLCI9A3; SLCIAI; SLCIA2; SLCIA3; SLCIA4; SLCIA5; SLCIAB; SLC2DAI: SLC20A2; SLC22AII; SLC2ZAI2; SLC22AI3; SLC22AI4;
[0569] SLC22AIB; SLC22AI7; SLC22AI8AS; SLC22AI8; SLC22AI; SLC22A23;
[0570] SLC22A24: SLC22A2; SLC22A3; SLC22A4; SLC22A5; SLC22AB;
[0571] SLC22A7; SLC22A8; SLCZ3AI; SLC23A2; SLC24AI; SLC24A2; SLC24A3; SLC24A4; SLC24A5; SLC25AIQ; SLC25AI2; SLC25AI3; SLC25AI4; SLC25AI5; SLC25AIB; SLC25AI8; SLC25AI9; SLC25AI; SLC25A20; SLCZ5A2I: SLC25A22; SLC25A23; SLC25A25;
[0572] SLC25A27; SLC25A2; SLC25A3B; SLC25A37; SLC25A38; SLC25A3; SLC25A40; SLC25A41; SLC25A42; SLC25A43; SLC25A45;
[0573] SLC25A4B; SLC25A47; SLC25A4; SLC25A52; SLC25A5; SLC25AB; SLC2BAI; SLC2BA2; SLC2BA3; SLC2BA4; SLC2BA5; SLC2BAB;
[0574] SLC2BA7; SLC2BA8; SLC2BA9; SLC27AI; SLC27A2; SLC27A3; SLC27A4; SLC27A5; SLC28AI; SLC28A2; SLC28A3; SLC29AI; SLC29A2;
[0575] SLC29A3; SLC29A4; SLC2AI0; SLC2AII; SLC2AI2; SLC2AI3; SLC2AI4; SLC2A2; SLC2A3; SLC2A4RG; SLC2A5; SLC2AB; SLC2A8; SLC2A9; SLC30AI0; SLC30AI: SLC30A3; SLC30A4; SLC30A5; SLC30AB; SLC30A7; SLC30A8; SLC30A9;
[0576] SLC3IAI: SLC3IA2; SLC32AI; SLC33AI; SLC34AI; SLC34A2; SLC34A3; SLC35AI; SLC35A2; SLG35A3; SLC35A4; SLC35B2; SLC35B4; SLC35CI: SLC35D3; SLC35FI;
[0577] SLC35F2; SLC35F3; SLC35F4; SLC35FB; SLC35GI; SLC35G2; SLC35G5; SLC35 GB; SLC3BAI; SLC3BA2; SLC37AI; SLC37A2;
[0578] SLC37A4; SLC38AI; SLC38A2; SLC38A4; SLC38A5; SLC38AB; SLC38A7; SLC38A8; SLC38A9; SLC39AID; SLC39AII; SLC39AI2;
[0579] SLC39AI3; SLC39AI4; SLC39AI; SLC39A2; SLC39A3; SLC39A4; SLC39AB; SLC39A7; SLC39A8; SLC39A9; SLG3AI; SLC3A2; SLC4DAI; SLC4IAI; SLC43AI; SLC43A2; SLC43A3; SLC44AI; SLC44A2; SLC44A4; SLC44A5; SLC45A2; SLC45A3; SLC45A4; SLC4BAI:
[0580] SLC4BA2; SLC47AI; SLC48AI; SLC4AIO; SLC4AII: SLC4AIAP; SLC4AI; SLC4A2; SLG4A3; SLC4A4; SLC4A5; SLC4A7; SLC4A9; SLC50AI;
[0581] SLC5IA; SLC5IB; SLC5ZAI; SLC52A2; SLC52A3; SLC5AII; SLC5AI2; SLC5AI: SLC5A2; SLC5A3; SLC5A4; SLC5A5; SLC5AB; SLC5A7;
[0582] SLC5A8; SLCBAII; SLCBAI2; SLCBAI3; SLGBAI4; SLCBAI5; SLCBAI8; SLCBAI9: SLCBAI: SLCBA20; SLCBA2; SLCBA4; SLCBA5; SLCBAB;
[0583] SLCBA7; SLCBAB; SLCBA9; SLC7AI0; SLC7AII; SLC7AI3; SLC7AI4; SLC7AI; SLC7A2; SLC7A3; SLC7A4; SLC7A5; SLC7AB; SLC7A7; SLC7A8; SLC7A9; SLCBAI: SLC8A2; SLC8A3; SLCBAI SLC9A2; SLC9A3; SLC9A3RI SLC9A3R2; SLC9A4; SLC9A5; SLCBAB; SLC9A7; SLCBAB; SLC9A9; SLC9BI: SLC9B2; SLC9CI; SLC9C2; SLGQIA2; SLCGIBi; SLC0IB3; SLCDIB7; SLCDICI: SLCD2AI: SLCD2BI; SLCB3AI;
[0584] SLCD4AI; SLCB4CI; SLCD5AI; SLCOBAI; SLFNI2; SLFNI2L; SLFNI4; SLFN5: SLITI: SLIT2; SLIT3; SLIT KI: SLITRK2; SLITRK3; SLITR 5;
[0585] SLITR B; SLK; SL AP; SLM02; SLN; SLPI; SLTM; SLU7; SLURPI: SLX4; SLX4IP; SMADI; SMAD2; SMAD3; S AD4; SMAD5; SMADB;
[0586] SMAD7; SMAD9; SMAGP; SMAPI; SMARCAI; SMARCA2; SMARCA4; SMARCA5; SMARCADI; SMARCALI; SMARCBI; SMARCCI; SMARCC2; SMARCDI; SMARCD3; SMARCEI; SMCIA; SMCIB; SMC2; SMC3; SMC4; SMC5; SMCB; SHCHDI; SMCD4; SMCP; SMEKI; SME 2; SMGI;
[0587] SMGB; SMG8; SMIMI5; SMIMI9; SMIM2D; SMIM2I; SMIM23; SMIM5; SMN2; SMDCI; SMBC2; SMO; SMQX; SMPDI; SMPD2; SMPD3;
[0588] SMPOL3A; SMPDL3B; SMPX; SMR3B; SMS; SMTN; SMTNLI; SMUI; SMUGI; SMURFI; SMURF2; SMYDI; SMYD2; SMYD3; SMYD4; SMYD5;
[0589] SNAII; SNAI2; SNAI3; SNAP23; SNAP25; SNAP29; SNAP47; SNAP9I; SNAPCI: SNAPC4; SNAPC5; SNCA; SNCAIP; SNCB; SNCG; SNDI;
[0590] SNEDI; SNF8; SNIPI: SNRK; SNRNP2BD; SNRNP27; SN NP7D; SNRPA; SNRPB; SNRPC; SN PDI: SNRPD3; SNRPE: SNRPF; SNRPN; SNTAI; SNTBI; SNTGI; SNTB2; SNUPN; SNURF; SNWI; SNXIO; SNXI2; SNXI4; SNXIB; SNXI8; SNXI9; SNXI: SNX2D; SNX24: SNX25;
[0591] SNX29; SNX2; SNX3D; SNX3; SNX5; SNX9; SB ATI; SDAT2; SDBP; SOCSI: SDCS2; SDCS3; SDCS4; SOCS5; SDCSB; SDCS7; SDDI;
[0592] SDD2; SDD3; SDHLHI; SDHLH2; SDN; SDRBSI; SDRBS2; SDRBS3; SDRCSI; SDRCS2; SDRCS3; SORD; SDRLI; SCSI: SOS2; SDSTDCI; SDST; SDXIO; SDXII: SDXI2; SDXI3; SDXI4; S0XI5; SDXI7; SDXI8; SOXI; S0X2I; SDX2; SDX3; SOX4; S0X5; SOXB; SDX7; SDX8; SDX9;
[0593] SPIOD; SPUD; SPI4D; SPI; SP2; SP3; SP4; SP5; SPB; SP7; SP8; SPAI7; SPACAI; SPACA3; SPAGIIA; SPAGIIB; SPAGIB; SPAGI; SPAG4; SPAG5; SPAGB; SPAG7; SPAG8; SPAG9; SPAM1; SPANXA2; SPANXBI: SPANXD; SPANXN4; SPARC; SPARCLI: SPAST; SPATAI3;
[0594] SPATAIB; SPATAI7; SPATAIB; SPATAIB; SPATA2D; SPATA2I; SPATA22; SPATA25; SPATA2; SPATA5; SPATA7; SPATA8; SPATA9; SPATCI;
[0595] SPC24; SPC25; SPCS3; SPDEF; SPDLI; SPDYA; SPECCI SPECCIL; SPEF2; SPEG; SPESPI; SPGII; SPG2D; SPG2I; SPG7; SPHKI; SPHK2;
[0596] SPHKAP; SPII; SPIB; SPIC; SPIDR; SPIN1; SPIN2A; SPINKI; SPINK2; SPIN4; SPIN5; SPIN6; SPINK7; SPINTI; SPINT2: SPNSI SPNS2;
[0597] SPOII: SPDCKI; SPDC 2; SPOC 3; SPDNt; SPDN2; SPDP; SPPI; SPP2; SPPL2A; SPPL2B; SPPL2C; SPPL3; SPREDI; SPRED2; SPRED3; SPR; SPRN; SPRRIA; SPRRIB; SPRR2A; SPRR2B; SPRR3; SPRTN; SPRYI; SPRY2; SPRY3; SPRY4; SPRYD7; SPSB3; SPSB4; SPTAI;
[0598] SPTANI; SPTB; SPTBNI; SPTBN2; SPTBN4; SPTBN5; SPTLCI; SPTLC2; SPTLC3; SPTSSB; SPTY2DI; SPZI: SOLE; SDRDL; SQSTMI: SRAI;
[0599] SRBDI; SRCAP; SRC; SRCINI; SRD5AI; SRD5A2; SRD5A3; SREBFI; SREBF2; SREKI; SREKIIPI; SRFBPI; SRF; SRGAP1; SRGAP2; SRGAP3;
[0600] SRGN; SRI; SRL; SRMS; SRPI4; SRPI9; SRPG8; SRP72; SRP9; SRPI; SRPK2; SRPRB; SRPR; SRPX2; SRPX; SRR; SRRMI; SRRM2;
[0601] SRRM4; SRRT; SRSFID; SRSFII; SRSFI2; SRSFI; SRSF2; SRSF3; SRSF4; SRSF5; SRSFB; SRSF7; SRSF9; SRXNI; SRY; SSI8; SSI8LI; SSB; SSBPI; SSBP2; SSFA2; SSHI; SSH2; SSMEMI; SSNAI; SSPN; SSPD; SSRI; SSR2; SSRPI; SSSCAI; SST; SSTRI; SSTR2; SSTR3;
[0602] SSTR4; SSTR5; SSUH2; SSXI SSX2B; SSX2IP; SSX4B; SSX5; STI3; STI4; STI8; ST20; ST3GALI; ST3GAL2; ST3GAL4; ST3GAL5;
[0603] ST3GALB; ST5; STBGALI; STBGAL2; STBGALNACI; STBGALNAC2; STGGALNAC4; STGGALNACB; ST7; ST7L; ST8SIAI; ST8SIA2; ST8SIA3;
[0604] ST8SIA4; ST8SIAB; STABI; STAB2; STAC3; STAC; STAGI; STAG2; STAGS; STAM2; STAMBP; STAMBPLI; STAM; STAPI; STAP2; STARDIO;
[0605] STARDI3; STARD3; STARD3NL; STARD5; STARD7; STARD8; STARD9; STAR; STATI; STAT2; STAT3; STAT4; STAT5A; STAT5B; STATE; STATH; STAU2; STBDI; STCI; STC2; STEAPI; STEAP2; STEAP3; STEAP4; STH; STIL; STIMI; STIM2; STIPI; ST IO; STKII: STKIIIP; ST I7A;
[0606] ST I7B; ST 19; STK24; ST 25; STK2B; STK3I; ST 32A; STK32B; ST 32C; STK33: ST 35; ST 38L; STK39; ST 3; STK4; STMN2; STMN3;
[0607] STMN4; STOM; STDMLI; STDML2; STOML3; STONI-GTF2AIL; STDNI: STOXI; STRAI3; STRAB; STRA8; STRADA; STRADB; STRAP; STRC;
[0608] STRN3; STRN4; STRN; STS; SH3A: STT3B; STUBI; STXII; STXIG; STXI7; STXI8; STXIA; STXIB; STX2; STX3; STX4: STX5; STXB; STX8;
[0609] STXBPI; STXBP2; STXBP4; STXBP5; STXBP5L; STXBPB; STYKI; STYX; SUBI; SUCLA2; SUCLGI; SUCLG2; SUCNRI: SUCO; SOOS3; SOFU; SUGCT; SOGPI; SUGTI; SULFI; SULF2; SULTIAI; SOLTIA2; SOLT1A4; SULTIBI; SULTIC2; SOLTIEI; SULT2A1: SOLT2BI; SULT4AI; SUMFI; SUMFZ; SUMDI; SUM02; SUM03; SUMD4; SUNI; SUN2; SUN3; SUOX; SUPT2DH; SUPT3H; SUPT4HI; SUPT7L; SUPV3LI; SURFI; SURF4;
[0610] SUSDI; SUSD2; SUSD4; SUSDB; SOV39HI; SUV39H2; SUV420H2; SUZI2; SV2B; SV2C; SVEPI SVIL; SVIP; SVOP; SWAP7D: SWTI; SYBU;
[0611] SYCEI; SYCEIL; SYCP2; SYCP2L; SYCP3; SYK; SYMPK; SYHI; SYN2; SYN3; SYNCRIP; SYNDIBI; SYNEI: SYNE2; SYNE4; SYNGAPI;
[0612] SYNGRI; SYNG 2; SYNJI: SYNJ2BP; SYNJ2; SYNM; SYNPO2; SYNPD; SYNPR; SYP; SYPLI; SYPL2; SYTII; SYT12; SYTI3; SYTI4; SYTI; SYT4; SYTB; SYT9; SYTLI; SYTL2; SmS; SYVNI; TAARI; TAAR2; TAAR5; TAARB; TABI; TAB2; TAB3; TACt; TAGS; TAC4; TACCI: TACC2;
[0613] TACC3; TACDI; TAC I; TACR2; TAGR3; TADAI; TADA2A; TADA3; TAFI5; TAFIB; TAFIC; TAFID; TAFI; TAF2; TAF3; TAF4B; TAF4; TAF5L;
[0614] TAFB; TAF7; TAF7L; TAF8; TAFB; TAGAP; TAGLN2; TAGLN; TALI; TAL2; TALDOI; TAMM4I; TANCI; TANC2; TANG02; TANK; TADKI; TAD 2;
[0615] TAD3; TAPI; TAP2; TAPBP; TAPBPL; TARBPI; TARBP2; TARP; TARS; TARSL2; TAS2RIB; TAS2RI3; TAS2RI4; TAS2RIB; TAS2RI;
[0616] TAS2R38; TAS2R5B; TAS2RBB; TAS2R9; TASPI; TATDNI; TAT; TAXIBPI; TAXIBP3; TAZ; TBATA; TBCIDI5; TBCIDIB; TBCIDI; TBCID2D; TBCID22A; TBCID22B; TBCID24; TBCID25; TBCID2; TBCID32; TBCID3C; TBCID3F; TBCID4; TBCID5; TBCID7; TBCID8; TBCID9; TBCA;
[0617] TBCC; TBCD; TBCE; TBCEL; M1: TBKBPI; TBLIX; TBLIXRI; TBLIY; TBL2; TBL3; TBP; TBPLI; TBPL2; TBRI; TBRGI; TBXID; TBXI8; TBXI9;
[0618] TBXI: TBX2D; TBX2I; TBX22; TBX2; TBX3; TBX4; TBX5; TBXB; TBXA2R; TBXASI; TCAIM; TCAP; TCEAI; TCEA2; TCEA3; TCEALI; TCEAL2;
[0619] TCEAL4; TCEAL7; TCEBI: TCEB2; TCEB3C; TGERGI; TCERGIL; TCFI2; TCFI5; TCFI9; TCF2B; TCF2I; TCF25; TCF3; TCF4; TCF7; TCF7LI;
[0620] TGF7L2; TCFL5; TCHH; TCHP; TGIRGI; TCLIA; TCLIB; TCNI; TCN2; TCDFI; TCPIB; TCPIDL2; TCPIILI; TCPI; TCTA; TCTEI; TCTNI; TCTN2; TCTN3; TDGFI; TDG; TDD2; TDPI; TDP2; TDRDI; TDRD3; TDRD5; TDRDB; TDRD7; TDRD9; TDR H; TDRP; TEADI; TEAD2; TEAD3; TEAD4;
[0621] TEC; TECPR2; TECR; TECRL; TECTA; TEF; TEFM; TEK; TEKTI; TEKT5; TEL02; TENMI; TENM2; TENM3; TENM4; TEPI; TEPP; TERFI; TERF2;
[0622] TERF2IP; TERT; TESC; TES; TESPAI TETI; TET2; TET3; TEXIDI; TEXII; TEXI4; TEXI5; TEX2B4; TEX29; TEX3D; TEX35; TEX40; TFAM; TFAP2A;
[0623] TFAP2B; TFAP2C; TFAP4; TFBIM; TFB2M; TFCP2; TFDPI: TFDP2; TFDP3; TFE3; TFEB; TFEC; TFFI: TFF2; TFF3; TFG; TF; TFIPII: TFPI2; TFPI;
[0624] TFPT; TFR2; TFRC; TGFA; TGFBI; TGFBIII; TGFB2; TGFB3; TGFBI; TGFBRI; TGFBR2; TGFBRAPI; TG; TGIFI; TGIF2-CZOorf24; TGIF2; TGIF2LX; TGMI; TGM2; TGM3; TGM4; TGM5; TGMB; TGM7; TGOLN2; TGSI: THADA; THAPIO; THAP1J: THAPI; THAP2; THAPG; THBD; THBSI;
[0625] THBS2; THBS3; THBS4; THEG; THEM4; THEM5; THE G; THEMIS2; THEMIS; THGIL; TH; THNSLI; THNSL2; THDCI; THDC2; THDC5; THDCB;
[0626] THDPI; THPD; THRA; THRB; THRSP; THSDI; THSD4; THSD7A; THYNI; TIAI: TIAFI TIALI; TIAMI: TIAM2; TICAMI; TICAM2; TICRR; TIFA;
[0627] TIGD2; TIGIT; TIMD4; TIMELESS; TIMMID; TIMMI7A; TIMM2I; TIMM22; TIMM23; TIMM44; TIMM5D; TIMM8A; TIMM8B; TIMMOCI; TIMPI;
[0628] TIMP2; TIMP3; TIMP4; TINAG; TINF2; TIPARP; TIPIN; TIPRL; TIRAP; TJPfc TJP2; TJP3; TKI; T 2; TKT; TKTLI; T TL2; TLDCI; TLEI; TLE2; TLE3; TLE4; TLEG; M1; TLK2; TLLI; TLL2; TLNI; TLN2; TLRIO; TLRI; TLR2; TLR3; TLR4; TLR5; TLRB; TLR7; TLR8; TLR9; TLXI; TLX2; TLX3;
[0629] TM4SFI; TM4SF2D; TM4SF4; TM4SF5; TMBSF2; TM7SF2; TM9SF2; TM9SF4; TMBIM4; TMBIMB; TMCI; TMC2; TMC3; TMC5; TMCB; TMC8;
[0630] TMCCI; TMCC2; TMCC3; TMCDI; TMCD4; TMCD5A; TMEDID; TMEDI; TMED2; TMED3; TMED4; TMED7; TMED7-TICAM2; TMEDB; TMEFFI;
[0631] TMEFF2; TMEMIOO; TMEMIDI; TMEMID5; TMEMIDBB; TMEMI08; TMEMII4; TMEMII5; TMEMII7; TMEMII; TMEMI2BA; TMEMI27; TMEMI28;
[0632] TMEMI32A; TMEMI32B; TMEMI32C; TMEMI32D; TMEMI32E; TMEMI34; TMEMI35; TMEMI38; TMEMI5DB; TMEMI5IA; TMEMI5IB; TMEMI54; TMEMI58; TMEMIGO; TMEMIBIB; TMEMIB3; TMEMIG5; TMEMIB9; TMEMI70A; TMEM17I; TMEMI73; TMEMI75; TMEMI7 GB; TMEMI78A;
[0633] TMEMI82; TMEMI83A; TMEMI84C; TMEMI85A; TMEMI87; TMEMI89; TMEMI89-UBE2VI; TMEMI8; TMEMI99; TMEM2DOA; TMEM205;
[0634] TMEM207; TMEM209; TMEM2I3; TMEM2I5; TMEM2IB; TMEM2I7; TMEM2I9; TMEM220; TMEM229A; TMEM23I; TMEM233; TMEM237;
[0635] TMEM24I; TMEM244; TMEM245; TMEM259; TMEM25; TMEM2BI; TMEM27; TMEM2; TMEM30A; TMEM30B; TMEM37; TMEM38A; TMEM38B;
[0636] TMEM39A; TMEM40; TMEM43; TMEM45A; TMEM47; TMEM50B; TMEM55A; TMEM57; TMEM5; TMEMBO; TMEMB2; TMEMB3A; TMEMB7; TMEM70; TMEM74B; TMEM79; TMEM87A; TMEM88; TMEM89; TMEM8B; TMEM95; TMEMB7; TMEM98: TMFI; TMIE; TMIGD2; TMIG03; TMLHE; TMODI: TMDD2; TMDD3; TMOD4; TMPO; TMPRSSIIA; TMPRSSIIB; TMPRSSIID; TMPRSSItE; TMPRSSI3; TMPRSSI5; TMPRSS2; TMPRSS3; TMPRSS4; T PRSSB: TMPRSS7; T PRSS9; TMSBID; TMSBI5B; TMSB4X; T TCI; TMTC2; TMTC3; TMXI: TMX2; TMX3; TNC;
[0637] TNFAIPI: TNFAIP2; TNFAIP3; TNFAIP6; TNFAIP8; TNFAIP8L2; TNFAIP8L3; TNF; TNFRSFIOA; TNFRSFfOB; TNFRSFIOC; TNFRSFIOD;
[0638] TNFRSFIIA; TNFRSFIIB; TNFRSF12A; TNFRSFI3B; TNFRSFI3C; TNFRSFI4; TNFRSFI8; TNFRSFIA; TNFRSFIB; TNF SF21; TNFRSFBB; TNFRSF8; TNFSFIO; TNFSFII; TNFSFI2; TNFSFI2-TNFSFI3; TNFSFI3B; TNFSFI3: TNFSFI4; TNFSFI5; TNFSFIB; TNFSF4; TNFSFB; TNFSF3;
[0639] TNIK; TNIPI; TNIP2; TNIP3; TNKI; TNK2; TNKS2; TNKS; TNMD; TNNCI; TNN; TNNII; TNNI2; TNNI3; TNNTI; TNNT2; TNNT3; TNPI; TNP2;
[0640] TNPBI; TNPB2; TNPD3; TNRCI8; TNRCBA; TNRCBB; TNR; TNSI; TNS2; TNS3; TNS4; TNXB; TOBI; TDB2; TOLLIP; TDMI TOMILl; TOMM20;
[0641] TOMM34; TOMM40; TOMM70A; TONSL; TOPI; TOP2A; TOP2B; TOP3A; TOP3B; TOPBPI; TOPORS; TORIA; TORIAIPI; TORIAIP2; TORIB;
[0642] TOR2A; TOX2; TOX3; TOX4; TOX; TP53AIPI; TP53BPI: TP53BP2; TP53; TP53III; TP53II3; TP53I3; TP53INPI; TP53INP2; TP53RK; TP53TG3C; TPB3; TP73; TPBG; TPCNI; TPCN2; TPD52; TPD52LI; TPD52L2; TPGS2; TPHI; TPH2; TPIt; TPKI; TPMI; TPM2; TPM3; TPM4;
[0643] TPMT; TPD; TPPI; TPP2; TPPP2; TPPP3; TPPP; TPRGI; TPR; TPRN; TPSABI; TPSB2; TPSDI; TPSGI; TPTI; TPTE2; TPTE; TPX2; TRA2A;
[0644] TRA2B; TRABD2A; TRABD; TRADD; TRAFI; TRAF2; TRAF3; TRAF3IPI; TRAF3IP2; TRAF4; TRAF5; TRAFB; TRAF7; TRAFDI: TRAKI; TRAK2;
[0645] TRAMI; TRAMILI; TRAM2; TRAPI; TRAPPCIO; TRAPPCII; TRAPPCI; TRAPPC2; TRAPPC4; TRAPPC9; TRATI; TRDMTI: TRDN; TREH; TREMI;
[0646] TREM2; TREMLI; TREML2; TRERFI; TREXI; TREX2; TRHDE; TRH; TRHR; TRIAPI; TRIBI; TRIB2; TRIB3; TRIMIO; TRIMII: TRIMI3; TRIMI5; TRIMIB; TRIMI7; TRIMZI TRIM22; TRIM23; TRIM24; TRIM25; TRIM2B; TRIM27; TRIM28; TRIM29; TRIM2; TRIM3I; TRIM32; TRIM34;
[0647] TRIM35; TRIM3B; TRIM37; TRIM38; TRIM39; TRIMS; TRIM40; TRIM42; TRIM44; TRIM50; TRIM5B; TRIM58; TRIM59; TRIMS; TRIMB2;
[0648] TRIMBB; TRIMB8; TRIMB9; TRIMB-TRIM34; TRIM7I; TRIM72; TRIM73; TRIM74; TRIMS; TRIMS; TRIDBP; TRIO: TRIPIO; TRIPII; TRIPI3;
[0649] TRIP4; TRIPB; TIQK; TRMTIOA; TRMTI2; TRMT1; TRMT44; TRMT5; TRMU; TRO; TROVE2; TRPAI; TRPCI; TRPC3; TRPC4AP; TRPC4; TRPC5;
[0650] TRPCG; TRPC7; TRPMI; TRPM2; TRPM3; TRPM4; TRPM5; TRPMB; TRPM7; TRPM8; TRPSI; TRPVfc TRPV2; TRPV3; TRPV4; TRPV5; TRPVB; TRRAP; TSACC; TSCI: TSC22DI; TSC22D3; TSC22D4; TSC2; TSEN2; TSEN34; TSEN54; TSFM; TSGIDI; TSGAIO; TSHR; TSHZI; TSHZ2;
[0651] TSHZ3; TSLP; TSNAX; TSN; TSPANIO; TSPANII; TSPANI2; TSPANI3; TSPANI4; TSPANIB; TSPANI8; TSPAN3I; TSPAH32; TSPAN33;
[0652] TSPAN4; TSPANB; TSPAN7; TSPAN8; TSPAN9; TSPEAR; TSPO2; TSPO; TSPYIO; TSPYI; TSPY3; TSPY4; TSPYLI; TSPYL2; TSPYL4;
[0653] TSPYL5; TSRI; TSSCI; TSSKIB; TSSK2; TSSK4; TSTA3; TSTDI; TST; TTB I; TTBK2; TTCI2; TTCI7; TTCI9; TTCI; TTC2IB; TTC28; TTC29;
[0654] TTC37; TTC39A; TTC39B; TTC3; TTC5; TTC6; TTC7A; TTC7B; TTC8; TTC9B; TTC9C: TTC9; TTFI; TTF2; TTII: TTI2; TTK; TTL; TTLLID; TTLLII; TTLLI2; mU; TTLL3; TTLL4; TTLL5; TTLLB; TTLL7; TTLL8; TTLL9; TTPA; TTR; TTYHI; TTYH2; TUBAIA; TUBAIB; TUBAIC; TUBA3D; TUBA4A;
[0655] TUBA8; TUBBI; TUBB2A; TUBB2B; TUBB3; TUBB4A; TUBB4B; TUBBB; TUBB; TUBDI; TUBEI: TUBGI; TUBG2; TOBGCP2; TUBGCP3;
[0656] TUBGCP4; TUBGCP5; TUBGCPB; TUB; TUFM; TUFTI; TULPI; TOLP2; TULP3; TOLP4; TUSCI; TUSC2; TUSC3; TUSC5; 1; TVP23B; TWFI;
[0657] TWISTI; TWIST2; TWSGI; TXK; TXLNG; TXN2; TXNDCI5; TXNDCIB; TXN0CI7; TXNDC5; TXN; TXNLI; TXNRD2; TXNRD3NB; TYK2; TYMP;
[0658] TYMS; TYR; TYRD3; TYROBP; TYRPI; TYSNDI TYWIB; U2AFI U2AF2; UACA; UAPI; UBAI; UBA2; UBA3; UBA7; UBACI; UBAC2; UBAPI; UBAP2; UBASH3A; UBASH3B; UBB; OBC; UBD; UBE2A; UBE2B; OBE2C; UBE2D1; UBE2D2; UBE2D3; UBE2EI; UBE2E2; UBE2E3; UBE2GI;
[0659] UBE2G2; UBE2H; UBE2I; UBE2JI; UBE2K; UBE2L3; UBE2LB; UBE2M; UBE2N; UBE202; UBE2DLI; UBE2R2; UBE2S; UBE2T; UBE2U;
[0660] UBE2VI; UBE2V2; UBE2Z; UBE3A; UBE3B; DBE3C; UBE4A; UBE4B: UBIAOI; UBL3; UBL4A; UBL5; UBL7; UBLCPI: UBNI; UBOX5; UBPI
[0661] UBOLNI; UBQLN2; UBOLNL; UBRI; UBR3; OBR4; OBR5; UBR7; UBTD2; UBTF; UBXNI; UBXN2A; UBXN2B; UBXN4; UCHLI; UCHL3; UCHL5;
[0662] UCKI; UCK2; UCKLI; UCMA; OCN2; UCN3; UCN; UCPI; UCP2; UCP3; UEVLD; UFOIL; UFLI; OFMI; UGCG; OGDH; UGGTI; UGGT2; UGP2; UGTIAIO; UGTIAI; UGTIA3; OGTIA4; UGTIA5; UGTIAB; UGTIA7; UGTIA8; UGTIA9; UGT2AI; UGT2A2; UGT2A3; DGT2BIO; UGT2BII; UGT2BI5; UGT2B28; UBT2B4; UGT2B7; UGT3A2; UGT8; UHMKI; UHRFIBPI; UHRFI; UHRF2; UIMCI; ULBPI; ULBP2; ULBP3; ULKI; ULK2; ULK3; ULK4;
[0663] UMBO; UMDOLI; UMPS; UNCII9; UNCI3A; UNCI3B; UNCI3C; UNCI3D; UNC45A; UNC45B; UNC5A; UNC5B; UNC5C; UNC5D; UNC79;
[0664] UNCB3A; UNC93BI; UNG; UPBI; UPFI; UPF2; UPF3A; UPF3B; UPKIA; UPKIB; UPK2; UPK3A; UPPI; UPP2; UPRT; UQCCI; UQCC2; UQCRB;
[0665] UDCRCI; UBCRC2; UQCRFSI UflCRO; URB2; URGCP; URII; URMI; URDCI; U OD; UROS; USBI; USEI USFi: USF2; USHIC; USHIG; USH2A; 5 USUI; USPIO; USPII; USPI2; USPI3; USPI4; USPI5; USPI7L2; USPI7L3D; USPI8; USP20; USP22; USP25; USP2B; USP28; USP2; USP32;
[0666] USP33; USP3B; USP37; USPS; USP4B; USP42; USP43; USP44; USP4B; USP48; USP49; USP4; USP5; USPB; USPBNL; USP7; USPS;
[0667] USP9X; USP9Y; USPLI; UST; UTFI; UTPI4A; UTPI4C; UTP2B; UTRN; UTS2B; UTS2; UTS2R; UTY; UVRAG; UVSSA; UXSI UXT; VACI4;
[0668] VAMPI; VAMP2; VAMP4; VAMP7; VAMP8; VANGL2; VAPA; VAPB; VARS2; VARS; VASHI; VASH2; VASP; VATI; VATIL; VAVI; VAV2; VAV3;
[0669] VAXI; VAX2; VBPI; VCAN; VCL; VCP; VCX2; VCX3A; VCX3B; VCX; VCY; VDACI; VDAC2; VDR; VEGFA; VEGFB; VEGFC; VENTX; VEPHI; VEZT; ID VGF; VGLLI; VGLL2; VGLL3; VGLL4; VHL; VHLL; VILI; VIM; VIPAS39; VIP; VIPRI; VIPR2; VIT; VKDRCI; VLDLR; VMA2I; VMDI; VMPI; VNIR2;
[0670] VNIR4; VNNI: VNN2; VNN3; VOPPI VPRBP; VPREBI; VPREB3; VPSII; VPSI3A; VPSI3B; VPSI3C; VPS2BA; VPS28; VPS33A; VPS33B;
[0671] VPS35; VPS3B; VPS37A; VPS37B; VPS37C; VPS39; VPS4I; VPS4A; VPS4B; VPS5I; VPS52; VPS53; VPS54; VPS72; VPS8; VRKI: VRK2;
[0672] VSIGID; VSIGI; VSIG2; VSIG4; VSNLI: VSTMI; VSXI; VSX2; VTAI; VTCNI; VTIIA; VTIIB; VTN; VWA2; VWA3A; VWA3B; VWA5A; VWA5BI:
[0673] VWA7; VWA8; VWCE: VWDE; VWF; WAPAL; WARS2; WARS; WASFI; WASF3; WASHI; WAS; WASL; WBPIL; WBP2; WBSCRI7; WBSCR22; 15 WDFY2; WDFY4; WDHDI; WDPCP; WDRII; WDRI2; WDRI7; WDRI9; WDRI; WDR2D; WDR2B; WDR3I; WDR34; WDR35; WDR3B; WDR37;
[0674] WDR43; WDR45B; WDR45; WDR4B; WDR48; WDR49; WDR4; WDR55; WDR5; WDRBD; WDRB2; WDRB4; WDRBB; WDR7D; WDR72;
[0675] WDR74; WDR7B; WDR78; WDR7; WDR8I; WDR83; WDR8B; WDR93; WEEI; WFDCI: WFDC2; WFSI; WHSCI; WHSCILI; WIFI: WIPFI WIPF2;
[0676] WIPF3; WIPII; WIPI2; WISPI; WISP2; WISP3; WLS; WNKI; WNK2; WNK3; WNK4; WNTIDA; WNTIDB; WNTII; WNTIB; WNTI; WNT2B; WNT2;
[0677] WNT3A; WNT3; WNT4; WNT5A: WNT5B; WNTB; WNT7A; WNT7B: WNT8A; WNT8B; WNT9A; WNT9B; WRAP53; WRB; WRN; WRN1P1; WSBI; WSCDI; WSCD2; WTI; WTAP; WTIP; WWCI; WWC2; WWDX; WWPI; WWP2; WWTRI; XAB2; XAFI; XAGEIB; XAGEIE; XBPI; XCLI; XCL2; XCRI;
[0678] XDH; XG; XIAP; XIRPI; XIRP2; XK; XKR4; XKRG; XKR9; XPA; XPC; XPNPEPI; XPNPEP2; XPNPEP3; XPDI; XPO4; XPD5; XPOB; XP07; XPRI;
[0679] XRCCI; XRCC2; XRCC3; XRCC4; XRCC5; XRCCBBPI; XRCCB; XRNI; XRN2; XRRAI; XXYLTI; XYLB; XYLTI; XYLT2; YAEIOI; YAPI; YARS2;
[0680] YBX2; YBX3; YDJC; YEATS4; YESI; YIFIA: YIPFI; YIPF3; YIPF5; YKTB; YLPMI; YMEILI; YPELI YPEL2; YPEL3; YPEL4; YPEL5; YTHDCI;
[0681] YTHDC2; YWHAB; YWHAE; YWHAG; YWHAH; YWHAD; YWHAZ; YYIAPI; YYI; ZACN; ZAK; ZAP7D; ZARI; ZARIL; ZASP; ZBEDI; ZBED4; ZBED5; 5 ZBPI; ZBTBID; ZBTBI2; ZBTBI4; ZBTBIB; ZBTBI7; ZBTBI8; ZBTB2D; ZBTB2I; ZBTB22; ZBTB24; ZBTB2; ZBTB32; ZBTB33; ZBTB34;
[0682] ZBTB38; ZBTB4I; ZBTB4B; Z8TB48; ZBTB49; ZBTB4; ZBTB5; ZBTB7C; ZBTB9; ZC2HCIB; ZC3HIO; ZC3HIIA; ZC3HI2C; ZC3HI2D; ZC3HI4;
[0683] ZC3HI5; ZC3H3; ZC3H4; ZC3H7A; ZC3H7B; ZC3HAVI; ZC3HCI; ZC4H2; ZCCHCII; ZCCHCI2; ZCCHCI4; ZCCHC2; ZCCHC3; ZCCHCB;
[0684] ZCCHC8; ZCRBI; ZCWPWI; ZDBF2; ZDHHCII; ZDHHCI2; ZDHHCI3; ZDHHCI4; ZDHHCI5; ZDHHCI7; ZDHHCI; ZDHHC2; ZDHHC7; ZDHHC8;
[0685] ZDHHC9; ZEBI; ZEB2; ZFAND3; ZFAND5; ZFANDB; ZFAT; ZFC3HI: ZFHX2; ZFHX3; ZFHX4; ZFPI; ZFP30; ZFP3B; ZFP3GLI ZFP3BL2; ZFP37; ZFP42; ZFP57; ZFPB4; ZFP82; ZFPBI; ZFPMI; ZFPM2; ZFR2; ZFR; ZFX; ZFY; ZFYVEI9; ZFYVE2I; ZFYVE2B; ZFYVE27; ZFYVE28; ZFYVE9;
[0686] ZGIBB; ZGLPI; ZGPAT; ZHXI; ZHX2; ZICI; ZIC2; ZIC3; ZIC4; ZIC5; ZIKI; ZIM2; ZKSCANI; ZKSCAN3; ZKSCAN7; ZMAT3; ZMAT4; ZMIZI;
[0687] ZMYM2; ZMYM3; ZMYM4; ZMYM5; ZMYNDID; ZMYNDII; ZMYND8; ZNFIDB; ZNFID7; ZNFID; ZNFII2; ZNFI2I: ZNFI3I; ZNFI32; ZNFI33; ZNFI4I;
[0688] ZNFI43; ZNFI4B; ZNFI48; ZNFI54; ZNFIBD; ZNFIB9; ZNFI75; ZNFI77; ZNFI82; ZNFI84; ZNFI85; ZNFI89; ZNFI97; ZNF2D2; ZNF2D5; ZNF2D;
[0689] ZNF2I2; ZNF2I4; ZNF2I5; ZNF2I7; ZNF224; ZNF22; ZNF23D; ZNF23B; ZNF239; ZNF23; ZNF248; ZNF24; ZNF253; ZMF2B0; ZHF2B3; 5 ZNF2G4; ZNF2BB; ZNF2B7; ZNF2B8; ZNF273; ZNF274; ZNF27B; ZNF277; ZNF280B; ZNF28DD; ZNF28I; ZNF282; ZNFZ8BB; ZNF29B: ZNF2; ZNF3DD; ZNF3II; ZNF3I8; ZNF32D; ZNF322; ZNF32; ZNF33D; ZNF33I; ZNF334; ZNF335: ZNF343; ZNF35D; ZNF354A; ZNF35;
[0690] ZNF3B5; ZNF3FJFJ; ZNF3B7; ZNF3B2; ZNF3B3: ZNF3S4; ZNF385A; ZNF385B; ZNF385D; ZNF39I: ZNF395; ZNF338; ZNF407; ZNF4ID;
[0691] ZNF415; ZNF4I3; ZNF4I; ZNF423; ZNF430; ZNF432; ZNF433; ZNF438; ZNF443; ZNF444; ZNF44; ZNF45I: ZNF45; ZNF4B2; ZNF4B9:
[0692] ZNF483; ZNF49D; ZNF4B2; ZNF4BB; ZNF5DI; ZNF5D7; ZNF5I2B; ZNF5I2; ZNF5I3; ZNF5IB; ZNF5I9; ZNF52I; ZNF53B; ZNF555; ZNF55B; 5 ZNF5B8; ZNF5B9; ZNF577; ZNF5SD; ZNF58I; ZNF582; ZNF583; ZNF585B; ZNF5B2: ZNF53B; ZNFBOB; ZNFBD7; ZNFB08; ZNFBI5;
[0693] ZNFBI8; ZNFB27; ZNFB23; ZNFB33; ZNFB44; ZNFB45; ZNFB4B; ZNFB52; ZNF654; ZNFSB4; ZNFBB7; ZNFBB8; ZNFG74; ZNFB7B; ZNFB78;
[0694] ZNFB83; ZNFB87; ZNFB83; ZNF703; ZNF7D4; ZNF7DB; ZNF7II; ZNF7I6; ZNF7I7; ZNF74B; ZNF74; ZNF750; ZNF7B3; ZNF7B4; ZNF7B5;
[0695] ZNF7B; ZNF774: ZNF77B; ZNF778; ZNF7B4; ZNF79; ZNF7; ZNF8DD: ZNF804A; ZNF804B; ZNF80; ZNF8I2; ZNF8I3; ZNFS1B; ZNF8I;
[0696] ZNF823; ZNF827; ZNF823; ZNFB3I: ZNF9I; ZNF32; ZNF33; ZNF38; ZNFX1; ZNHIT2; ZNHIT3; ZNRDI; ZN F3; ZPI; ZP4; ZPBP2; ZPLDI; ID ZPRI; ZRANB3; ZRSR2; ZSCANI8; ZSCAN22; ZSCAN2B; ZSCAN3I: ZSCAN32; ZSCAN9; ZSWIM2; ZSWIMB; ZWIO: ZWILCH; ZW1NT; ZYX;
[0697] ZZEFI; and ZZZ3.
[0698] In some embodiments, the therapeutic protein is selected from the group consisting of OTC, ASL, PAH, ABCB4, ABCB11, PAH, AGL, CFTR, MUT, PCCA, PCCB, ASS1, FAH, HMBS, ATP7B, PFIC2, LDLR, G6PC, AGXT, FXN, PAL, BCKDHA, BCKDHB, DBT, UGT1A1, SLC25A13, CD46, CFH, CFI, FIX, FVII, FVIII, C2, C3, C5, GCHD, CBS, MPI, LNL, SERPINGI, UROC1, SMPD1, GLA, GAA, GRHPR, ATP8B1, SERPINCI, PROS1, GBA, ACADVL, HFE, BCKDA, CDG1B, SERPINA1, BMPR2, ENG, ACVR1, SMAD4, BMPR9, HBB, FLCN, HSP1, AP3B1, HPS3, HPS4, HPS5, HPS6, DTNBP1, BLOC1S3, PLDN, AP3D1, BRAF, NF-1, SLC34A2, FBN1, COL1A1, COL1A2, COL1A3, COL5A1, COL5A2, ADAMTS2, PLOD1, TNXB, ABCA3, SP-B, SP-C, GBA, NPC1, NPC2, FOXF1, NKX2-1, SFTPB, SFTPC, ABCA3, CSF2RA, SFTPD, MUC5B, BMPR2, EIF2AK4, CSF2RB, DNAH5, DNAI1, DNAH11, AKR1D1, AMACR, ATP8B1, CYP7A1, FOXC2, GATA2, GHR, HSD3B7, IGFALS, IKBKG, JAGI, KIF11, NOTCHI, NOTCH2, NR1H4, SOX18, TJP2, P53, P73, P63, VIPAS39, VPS33B, EPO, ARGI, CPS1, NAGS, NOS, KRAS, OX40L, IL12, VEGF-A, MMA, TTR, PCSK9, AT, and ALAS1.
[0699] Lipid-Based Formulations
[0700] Lipid-based formulations have been increasingly recognized as one of the most promising delivery systems (also referred to herein as a delivery vehicle or carrier) for RNA due to their biocompatibility and their ease of large-scale production. Cationic lipids have been widely studied as synthetic materials for delivery of RNA. After mixing together, nucleic acids are condensed by cationic lipids to form lipid/nucleic acid complexes known as lipoplexes. These lipid complexes are able to protect genetic material from the action of nucleases and to deliver it into cells by interacting with the negatively charged cell membrane. Lipoplexes can be prepared by directly mixing positively charged lipids at physiological pH with negatively charged nucleic acids.
[0701] Conventional liposomes consist of a lipid bilayer that can be composed of cationic, anionic, or neutral (phospho) lipids and cholesterol, which encloses an aqueous core. Both the lipid bilayer and the aqueous space can incorporate hydrophobic or hydrophilic compounds, respectively. Liposome characteristics and behaviour in vivo can be modified by addition of a hydrophilic polymer coating, e.g. polyethylene glycol (PEG), to the liposome surface to confer steric stabilization. Furthermore, liposomes can be used for specific targeting by attaching ligands (e.g., antibodies, peptides, and carbohydrates) to its surface or to the terminal end of the attached PEG chains (Front Pharmacol. 2015 Dec. 1; 6:286).
[0702] Liposomes are colloidal lipid-based and surfactant-based delivery systems composed of a phospholipid bilayer surrounding an aqueous compartment. They may present as spherical vesicles and can range in size from 20 nm to a few microns. Cationic lipid-based liposomes are able to complex with negatively charged nucleic acids via electrostatic interactions, resulting in complexes that offer biocompatibility, low toxicity, and the possibility of the large-scale production required for in vivo clinical applications. Liposomes can fuse with the plasma membrane for uptake; once inside the cell, the liposomes are processed via the endocytic pathway and the genetic material is then released from the endosome/carrier into the cytoplasm. Liposomes have long been perceived as drug delivery vehicles because of their superior biocompatibility, given that liposomes are basically analogs of biological membranes, and can be prepared from both natural and synthetic phospholipids (Int J Nanomedicine. 2014; 9: 1833-1843).
[0703] Cationic liposomes have been traditionally the most commonly used non-viral delivery systems for oligonucleotides, including plasmid DNA, antisense oligos, and siRNA/small hairpin R A-shRNA). Cationic lipids, such as DOTAP, (1,2-dioleoyl-3-trimethylammonium-propane) and DOTMA (N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethyl-ammonium methyl sulfate) can form complexes or lipoplexes with negatively charged nucleic acids to form nanoparticles by electrostatic interaction, providing high in vitro transfection efficiency. Furthermore, neutral lipid-based nanoliposomes for RNA delivery as e.g. neutral 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC)-based nanoliposomes were developed. (Adv Drug Deliv Rev. 2014 February; 66: 110-116.)
[0704] Preferably, the expressible polynucleotides and heterologous mRNA constructs described herein are lipid formulated. The lipid formulation is preferably selected from, but not limited to, liposomes, lipoplexes, copolymers, such as PLGA, and lipid nanoparticles. In one preferred embodiment, a lipid nanoparticle (LNP) comprises:
[0705] (a) a nucleic acid,
[0706] (b) a cationic lipid,
[0707] (c) an aggregation reducing agent (such as polyethylene glycol (PEG) lipid or PEG-modified lipid),
[0708] (d) optionally a non-cationic lipid (such as a neutral lipid), and
[0709] (e) optionally, a sterol.
[0710] Preferably, the lipid nanoparticle formulation consists of (i) at least one cationic lipid; (ii) a neutral lipid; (iii) a sterol, e.g., cholesterol; and (iv) a PEG-lipid, in a molar ratio of about 20-60% cationic lipid: 5-25% neutral lipid: 25-55% sterol; 0.5-15% PEG-lipid.
[0711] Some examples of lipids and lipid compositions for delivery of an active molecule of this disclosure are given in WO/2015/074085 and U.S. Ser. No. 15/387,067, each of which is hereby incorporated by reference in its entirety. In certain embodiments, the lipid is a compound of the following Formula I:
##STR00002##
wherein
R.sub.1 and R.sub.2 both consist of a linear alkyl consisting of 1 to 14 carbons, or an alkenyl or alkynyl consisting of 2 to 14 carbons;
L.sub.1 and L.sub.2 both consist of a linear alkylene or alkenylene consisting of 5 to 18 carbons, or forming a heterocycle with N;
X is S;
[0712] L.sub.3 consists of a bond or a linear alkylene consisting of 1 to 6 carbons, or forming a heterocycle with N;
R.sub.3 consists of a linear or branched alkylene consisting of 1 to 6 carbons; and
R.sub.4 and R.sub.5 are the same or different, each consisting of a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons;
or a pharmaceutically acceptable salt thereof.
[0713] The lipid formulation may contain one or more ionizable cationic lipids selected from among the following (also referred to herein as “ATX lipids”):
##STR00003## ##STR00004## ##STR00005## ##STR00006## ##STR00007## ##STR00008## ##STR00009##
[0714] The lipid nanoparticle preferably includes a cationic lipid suitable for forming a lipid nanoparticle. Preferably, the cationic lipid carries a net positive charge at about physiological pH. The cationic lipid may be, for example, N,N-dioleyl-N,N-dimethylammonium chloride (DODAC), N,N-distearyl-N,N-dimethylammonium bromide (DDAB), 1,2-dioleoyltrimethylammoniumpropane chloride (DOTAP) (also known as N-(2,3-dioleoyloxy)propyl)-N,N,N-trimethylammonium chloride and 1,2-Dioleyloxy-3-trimethylaminopropane chloride salt), N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium chloride (DOTMA), N,N-dimethyl-2,3-dioleyloxy)propylamine (DODMA), 1,2-DiLinoleyloxy-N,N-dimethylaminopropane (DLinDMA), 1,2-Dilinolenyloxy-N,N-dimethylaminopropane (DLenDMA), 1,2-di-y-linolenyloxy-N,N-dimethylaminopropane (y-DLenDMA), 1,2-Dilinoleylcarbamoyloxy-3-dimethylaminopropane (DLin-C-DAP), 1,2-Dilinoleyoxy-3-(dimethylamino)acetoxypropane (DLin-DAC), 1,2-Dilinoleyoxy-3-morpholinopropane (DLin-MA), 1,2-Dilinoleoyl-3-dimethylaminopropane (DLinDAP), 1,2-Dilinoleylthio-3-dimethylaminopropane (DLin-S-DMA), 1-Linoleoyl-2-linoleyloxy-3-dimethylaminopropane (DLin-2-DMAP), 1,2-Dilinoleyloxy-3-trimethylaminopropane chloride salt (DLin-TMA.CI), 1,2-Dilinoleoyl-3-trimethylaminopropane chloride salt (DLin-TAP.CI), 1,2-Dilinoleyloxy-3-(N-methylpiperazino)propane (DLin-MPZ), or 3-(N,N-Dilinoleylamino)-1,2-propanediol (DLinAP), 3-(N,N-Dioleylamino)-1,2-propanedio (DOAP), 1,2-Dilinoleyloxo-3-(2-N,N-dimethylamino)ethoxypropane (DLin-EG-DM A), 2,2-Dilinoleyl-4-dimethylaminomethyl-[1,3]-dioxolane (DLin-K-DMA) or analogs thereof, (3aR,5s,6aS)—N,N-dimethyl-2,2-di((9Z,12Z)-octadeca-9,12-dienyl)tetrahydro-3aH-cyclopenta[d][1,3]dioxol-5-amine, (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl4-(dimethylamino)butanoate (MC3), 1,1′-(2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethylazanediyl)didodecan-2-ol (C12-200), 2,2-dilinoleyl-4-(2-dimethylaminoethyl)-[1,3]-dioxolane (DLin-K-C2-DMA), 2,2-dilinoleyl-4-dimethylaminomethyl-[1,3]-dioxolane (DLin-K-DMA), (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28 31-tetraen-19-yl 4-(dimethylamino) butanoate (DLin-M-C3-DMA), 3-((6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,3 1-tetraen-19-yloxy)-N,N-dimethylpropan-1-amine (MC3 Ether), 4-((6Z,9Z,28Z,31 Z)-heptatriaconta-6,9,28,31-tetraen-19-yloxy)-N,N-dimethylbutan-1-amine (MC4 Ether), or any combination of any of the foregoing. Other cationic lipids include, but are not limited to, N,N-distearyl-N,N-dimethylammonium bromide (DDAB), 3P—(N—(N′,N′-dimethylaminoethane)-carbamoyl)cholesterol (DC-Choi), N-(1-(2,3-dioleyloxy)propyl)-N-2-(sperminecarboxamido)ethyl)-N,N-dimethylammonium trifluoracetate (DOSPA), dioctadecylamidoglycyl carboxyspermine (DOGS), 1,2-dileoyl-sn-3-phosphoethanolamine (DOPE), 1,2-dioleoyl-3-dimethylammonium propane (DODAP), N-(1,2-dimyristyloxyprop-3-yl)-N,N-dimethyl-N-hydroxyethyl ammonium bromide (DMRIE), and 2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane (XTC). Additionally, commercial preparations of cationic lipids can be used, such as, e.g., LIPOFECTIN (including DOTMA and DOPE, available from GIBCO/BRL), and Lipofectamine (comprising DOSPA and DOPE, available from GIBCO/BRL).
[0715] Other suitable cationic lipids are disclosed in International Publication Nos. WO 09/086558, WO 09/127060, WO 10/048536, WO 10/054406, WO 10/088537, WO 10/129709, and WO 2011/153493; U.S. Patent Publication Nos. 2011/0256175, 2012/0128760, and 2012/0027803; U.S. Pat. No. 8,158,601; and Love et al, PNAS, 107(5), 1864-69, 2010.
[0716] Other suitable amino lipids include those having alternative fatty acid groups and other dialkylamino groups, including those, in which the alkyl substituents are different (e.g., N-ethyl-N-methylamino-, and N-propyl-N-ethylamino-). In general, amino lipids having less saturated acyl chains are more easily sized, particularly when the complexes must be sized below about 0.3 microns, for purposes of filter sterilization. Amino lipids containing unsaturated fatty acids with carbon chain lengths in the range of C14 to C22 may be used. Other scaffolds can also be used to separate the amino group and the fatty acid or fatty alkyl portion of the amino lipid.
[0717] Preferably, the LNP comprises the cationic lipid with formula (III) according to the patent application PCT/EP2017/064066. In this context, the disclosure of PCT/EP2017/064066 is also incorporated herein by reference.
[0718] Preferably, amino or cationic lipids of the disclosure have at least one protonatable or deprotonatable group, such that the lipid is positively charged at a pH at or below physiological pH (e.g. pH 7.4), and neutral at a second pH, preferably at or above physiological pH. It will, of course, be understood that the addition or removal of protons as a function of pH is an equilibrium process, and that the reference to a charged or a neutral lipid refers to the nature of the predominant species and does not require that all of the lipid be present in the charged or neutral form. Lipids that have more than one protonatable or deprotonatable group, or which are zwitterionic, are not excluded from use in the disclosure. In certain embodiments, the protonatable lipids have a pKa of the protonatable group in the range of about 4 to about 11, e.g., a pKa of about 5 to about 7.
[0719] The cationic lipid can comprise from about 20 mol % to about 70 or 75 mol % or from about 45 to about 65 mol % or about 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, or about 70 mol % of the total lipid present in the particle. In another embodiment, the lipid nanoparticles include from about 25% to about 75% on a molar basis of cationic lipid, e.g., from about 20 to about 70%, from about 35 to about 65%, from about 45 to about 65%, about 60%, about 57.5%, about 57.10%, about 50% or about 40% on a molar basis (based upon 100% total moles of lipid in the lipid nanoparticle). In one embodiment, the ratio of cationic lipid to nucleic acid is from about 3 to about 15, such as from about 5 to about 13 or from about 7 to about 11.
Pharmaceutical Compositions
[0720] Preferably, the disclosure provides pharmaceutical compositions containing a codon optimized mRNA encoding a modified human therapeutic protein of interest preferably formulated in a lipid delivery system or lipid carrier and preferably comprising pharmaceutically acceptable excipients. Pharmaceutical compositions disclosed herein preferably facilitate expression of mRNA in vivo.
[0721] Suitable routes of administration include, for example, oral, rectal, vaginal, transmucosal, pulmonary including intratracheal or inhaled, or intestinal administration; parenteral delivery, including intradermal, transdermal (topical), intramuscular, subcutaneous, intramedullary injections, as well as intrathecal, direct intraventricular, intravenous, intraperitoneal, or intranasal.
[0722] Preferably, the intramuscular administration is to a muscle selected from the group consisting of skeletal muscle, smooth muscle and cardiac muscle. In some embodiments the administration results in delivery of the mRNA to a muscle cell. In some embodiments the administration results in delivery of the mRNA to a hepatocyte (i.e., liver cell). In a particular embodiment, the intramuscular administration results in delivery of the mRNA to a muscle cell.
[0723] Preferably, mRNAs and lipid formulations thereof may be administered in a local rather than systemic manner, for example, via injection of the pharmaceutical composition directly into a targeted tissue, preferably in a sustained release formulation. Local delivery can be affected in various ways, depending on the tissue to be targeted. For example, aerosols containing compositions of the present disclosure can be inhaled (for nasal, tracheal, or bronchial delivery); can be supplied in liquid, tablet or capsule form for administration to the stomach or intestines, can be supplied in suppository form for rectal or vaginal application; or can even be delivered to the eye by use of creams, drops, or even injection. Formulations containing provided compositions complexed with therapeutic molecules or ligands can even be surgically administered, for example in association with a polymer or other structure or substance that can allow the compositions to diffuse from the site of implantation to surrounding cells. Alternatively, they can be applied surgically without the use of polymers or supports.
[0724] Pharmaceutical compositions may be administered to any desired tissue. In some embodiments, the modified therapeutic protein-encoding mRNA delivered by provided liposomes or compositions is expressed in the tissue in which the liposomes and/or compositions were administered. In some embodiments, the mRNA delivered is expressed in a tissue different from the tissue in which the liposomes and/or compositions were administered. Exemplary tissues in which delivered mRNA may be delivered and/or expressed include, but are not limited to the liver, kidney, heart, spleen, serum, brain, skeletal muscle, lymph nodes, skin, and/or cerebrospinal fluid.
[0725] Preferably, a pharmaceutical composition can contain a polynucleotide described herein such as a primary DNA construct or mRNA described herein within a viral or bacterial vector.
[0726] Preferably, the primary DNA construct for an mRNA described herein or an mRNA described herein can be formulated using one or more excipients to: (1) increase stability; (2) increase cell transfection; (3) permit a sustained or delayed release (e.g., from a depot formulation of the polynucleotide, primary construct, or mRNA); (4) alter the biodistribution (e.g., target the polynucleotide, primary construct, or mRNA to specific tissues or cell types); (5) increase the translation of encoded protein in vivo; and/or (6) alter the release profile of encoded protein in vivo.
[0727] In addition to traditional excipients such as any and all solvents, dispersion media, diluents, or other liquid vehicles, dispersion or suspension aids, surface active agents, isotonic agents, thickening or emulsifying agents, preservatives, excipients of the present disclosure can include, without limitation, liposomes, lipid nanoparticles, polymers, lipoplexes, core-shell nanoparticles, peptides, proteins, cells transfected with primary DNA construct, or mRNA (e.g., for transplantation into a subject), hyaluronidase, nanoparticle mimics and combinations thereof.
[0728] Accordingly, the formulations described herein can include one or more excipients, each in an amount that together increases the stability of the primary DNA construct, or mRNA, increases cell transfection by the primary construct, or mRNA, increases the expression of polynucleotide, primary construct, or mRNA encoded protein, and/or alters the release profile of polynucleotide, primary construct, or mRNA encoded proteins. Further, the primary construct and mRNA of the present disclosure may be formulated using self-assembled nucleic acid nanoparticles.
[0729] Formulations of the pharmaceutical compositions described herein may be prepared by any method known or hereafter developed in the art of pharmacology. In general, such preparatory methods include the step of associating the active ingredient with an excipient and/or one or more other accessory ingredients.
[0730] A pharmaceutical composition in accordance with the present disclosure may be prepared, packaged, and/or sold in bulk, as a single unit dose, and/or as a plurality of single unit doses. As used herein, a “unit dose” refers to a discrete amount of the pharmaceutical composition comprising a predetermined amount of the active ingredient. The amount of the active ingredient may generally be equal to the dosage of the active ingredient which would be administered to a subject and/or a convenient fraction of such a dosage including, but not limited to, one-half or one-third of such a dosage.
[0731] Relative amounts of the active ingredient, the pharmaceutically acceptable excipient, and/or any additional ingredients in a pharmaceutical composition in accordance with the present disclosure may vary, depending upon the identity, size, and/or condition of the subject being treated and further depending upon the route by which the composition is to be administered. For example, the composition may comprise between 0.10% and 99% (w/w) of the active ingredient.
[0732] Pharmaceutical formulations may additionally comprise a pharmaceutically acceptable excipient, which, as used herein, includes, but is not limited to, any and all solvents, dispersion media, diluents, or other liquid vehicles, dispersion or suspension aids, surface active agents, isotonic agents, thickening or emulsifying agents, preservatives, and the like, as suited to the particular dosage form desired.
[0733] Various excipients for formulating pharmaceutical compositions and techniques for preparing the composition are known in the art (see Remington: The Science and Practice of Pharmacy, 21st Edition, A. R. Gennaro, Lippincott, Williams & Wilkins, Baltimore, Md., 2006; incorporated herein by reference in its entirety). The use of a conventional excipient medium may be contemplated within the scope of the embodiments of the present disclosure, except insofar as any conventional excipient medium may be incompatible with a substance or its derivatives, such as by producing any undesirable biological effect or otherwise interacting in a deleterious manner with any other component(s) of the pharmaceutical composition.
Therapeutic Uses
[0734] The mRNA sequences, primary DNA constructs that transcribe the mRNA sequences described herein and pharmaceutical compositions thereof provide numerous in vivo and in vitro methods and are useful to treat deficiency of a protein. The treatment may comprise treating a human patient with deficiency of a protein. Similarly, compositions described herein, may be used in vitro or ex vivo to study OTC deficiency in cell or animal-based models. For example, cells deficient for the protein of interest expression can be used to analyze the ability to restore expression and/or activity of the protein of interest, as well as the time period over which expression and/or activity persists. Such cells and animal models are also suitable to identify other factors involved in the pathway, whether binding partners or factors in the same biochemical pathway. In other embodiments, compositions described herein can be used to study or track mitochondrial delivery.
[0735] Polynucleotides described herein, such as a DNA construct or template or an mRNA sequence described herein can be delivered to patients or cells experiencing deficiency of the protein of interest. For example, the mRNA sequence can comprise SEQ ID NO: 119 encoding a modified protein of SEQ ID NO: 4. In another example, the DNA sequence comprises SEQ ID NO: 221 encoding a modified protein of SEQ ID NO: 4.
[0736] Following administration, the modified protein of interest is expressed in the cells or subject. The modified protein of interest can have a signal peptide that directs it for secretion or to be a membrane bound protein. Preferably, compositions described herein are delivered to a targeted organelle. In some embodiments, the organelle can be selected from the group consisting of a mitochondrion, a nucleus, a lysosome, a peroxisome, an endoplasmic reticulum, a Golgi apparatus, and a plasma membrane. In some embodiments, compositions described herein are delivered to liver cells.
[0737] Examples of mRNA sequences for use with these methods include those listed in Table 5. Exemplary cDNA templates used to transcribe the mRNA sequences described herein are listed in Table 6. Exemplary mRNA sequences for administering to patients for treatment of a protein deficiency are SEQ ID NOS: 1799 and SEQ ID NOS: 1921.
[0738] In some embodiments, a polynucleotide described herein encoding a modified therapeutic protein described herein can be used in a gene therapy. Gene therapy is a technique that uses genes to treat or prevent disease, and can be used to treat a disorder by inserting a gene into a subject's cells. In some embodiments a polynucleotide encoding a modified therapeutic protein described herein replaces a mutated gene that causes disease. In other embodiments, a polynucleotide encoding a modified therapeutic protein described herein is used to inactivate, or “knock out,” a mutated gene that is functioning improperly. In yet other embodiments, a polynucleotide encoding a modified therapeutic protein described herein introduces a new gene into a subject to help fight a disease.
[0739] The gene therapy methods can use a carrier or vector that is genetically engineered to deliver the gene. In some embodiments, the vector is a viral-based vector. The vector can be injected or given intravenously (by IV) directly into a specific tissue in the body, where it is taken up by individual cells. Alternatively, a sample of the subject's cells can be removed and exposed to the vector ex vivo. The cells containing the vector are then returned to the subject.
Dosing
[0740] An effective dose of a mRNA, a protein or pharmaceutical formulations thereof of the present disclosure can be an amount that is sufficient to treat ORF protein deficiency in a cell and/or in a patient. A therapeutically effective dose can be an amount of an agent or formulation that is sufficient to cause a therapeutic effect. A therapeutically effective dose can be administered in one or more separate administrations, and by different routes. Generally, a therapeutically effective amount is sufficient to achieve a meaningful benefit to the subject (e.g., treating, modulating, curing, preventing and/or ameliorating phenylketonuria). For example, a therapeutically effective amount may be an amount sufficient to achieve a desired therapeutic and/or prophylactic effect. Generally, the amount of a therapeutic agent administered to a subject in need thereof will depend upon the characteristics of the subject. Such characteristics include the condition, disease severity, general health, age, sex and body weight of the subject. One of ordinary skill in the art will be readily able to determine appropriate dosages depending on these and other related factors. In addition, both objective and subjective assays may optionally be employed to identify optimal dosage ranges.
[0741] Methods provided herein contemplate single as well as multiple administrations of a therapeutically effective amount of an mRNA sequence described herein. Pharmaceutical compositions comprising an mRNA sequence encoding an ORF protein described herein can be administered at regular intervals, depending on the nature, severity and extent of the subject's condition. Preferably, a therapeutically effective amount an mRNA sequence of the present disclosure may be administered periodically at regular intervals (e.g., once every year, once every six months, once every four months, once every three months, once every two months, once a month), biweekly, weekly, daily, twice a day, three times a day, four times a day, five times a day, six times a day, or continuously.
[0742] Preferably, the pharmaceutical compositions of the mRNA of the present disclosure are formulated such that they are suitable for extended-release of the translatable compound encoding a modified protein described herein contained therein. Such extended-release compositions may be conveniently administered to a subject at extended dosing intervals. For instance, in one embodiment, the pharmaceutical compositions of the present disclosure are administered to a subject twice a day, daily or every other day. In some embodiments, the pharmaceutical compositions of the present disclosure are administered to a subject twice a week, once a week, every 10 days, every two weeks, every 28 days, every month, every six weeks, every eight weeks, every other month, every three months, every four months, every six months, every nine months or once a year. Also contemplated herein are pharmaceutical compositions which are formulated for depot administration (e.g., subcutaneously, intramuscularly) to either deliver or release an mRNA sequence encoding a modified protein described herein over extended periods of time. Preferably, the extended-release means employed are combined with modifications made to the translatable compound encoding a modified protein described herein to enhance stability.
[0743] A therapeutically effective dose, upon administration, can result in serum or plasma levels of the modified therapeutic protein of interest of 1-1000 pg/ml, or 1-1000 ng/ml, or 1-1000 pg/ml, or more. In some embodiments, administering a therapeutically effective dose of a composition comprising an mRNA sequence described herein can result in increased modified protein levels in a targeted tissue (e.g., liver, eyes, lungs, skin, etc.) of a treated subject. Preferably, administering a composition comprising a mRNA described herein results in a 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 95% increase in modified protein levels in the targeted tissue relative to a baseline modified protein level in the subject prior to treatment. Preferably, administering a therapeutically effective dose of a composition comprising an mRNA described herein will result an increase in levels of the modified protein in the targeted tissue relative to baseline levels of the protein of interest in the subject prior to treatment. In some embodiments, the increase in modified protein levels in the targeted tissue relative to baseline levels of the protein of interest will be at least 5%, 10%, 20%, 30%, 40%, 50%, 100%, 200%, or more.
[0744] Preferably, a therapeutically effective dose, when administered regularly, results in increased expression of the therapeutic protein of interest in the liver as compared to baseline levels prior to treatment. Preferably, administering a therapeutically effective dose of a composition comprising an mRNA sequence described herein results in the expression of a modified protein level at or above about 10 ng/mg, about 20 ng/mg, about 50 ng/mg, about 100 ng/mg, about 150 ng/mg, about 200 ng/mg, about 250 ng/mg, about 300 ng/mg, about 350 ng/mg, about 400 ng/mg, about 450 ng/mg, about 500 ng/mg, about 600 ng/mg, about 700 ng/mg, about 800 ng/mg, about 900 ng/mg, about 1000 ng/mg, about 1200 ng/mg or about 1500 ng/mg of the total protein in the liver of a treated subject.
[0745] A therapeutically effective dose of an mRNA described herein in vivo can be a dose of about 0.001 to about 500 mg/kg body weight. For instance, the therapeutically effective dose may be about 0.001-0.01 mg/kg body weight, or 0.01-0.1 mg/kg, or 0.1-1 mg/kg, or 1-10 mg/kg, or 10-100 mg/kg. Preferably, a Lipid-enabled and Unlocked Nucleomonomer Agent modified RNA (LUNAR)-mRNA (see WO/2015/074085 and U.S. Ser. No. 15/387,067), encoding a modified protein described herein, is provided at a dose ranging from about 0.1 to about 10 mg/kg body weight.
[0746] Combinations
[0747] The cDNA primary constructs, mRNA or encoded modified therapeutic proteins described herein may be used in combination with one or more other therapeutic, prophylactic, diagnostic, or imaging agents. By “in combination with,” it is not intended to imply that the agents must be administered at the same time and/or formulated for delivery together, although these methods of delivery are within the scope of the present disclosure. Compositions can be administered concurrently with, prior to, or subsequent to, one or more other desired therapeutics or medical procedures. In general, each agent will be administered at a dose and/or on a time schedule determined for that agent. Preferably, the methods of treatment of the present disclosure encompass the delivery of pharmaceutical, prophylactic, diagnostic, or imaging compositions in combination with agents that may improve their bioavailability, reduce and/or modify their metabolism, inhibit their excretion, and/or modify their distribution within the body. As a non-limiting example, mRNA disclosed herein, encoding a modified protein of SEQ ID NO: 4 may be used in combination with a pharmaceutical agent for the treatment of OTC deficiency. The pharmaceutical agent includes, but is not limited to one or more of: sodium phenylbutyrate, glycerol phenylbutyrate, sodium phenylacetate, sodium benzoate, arginine, citrulline, Multiple vitamins, calcium supplements or combined with low protein/high caloric diet. In general, it is expected that agents utilized in combination with be utilized at levels that do not exceed the levels at which they are utilized individually. In some embodiments, the levels utilized in combination will be lower than those utilized individually. In one embodiment, the combinations, each or together may be administered according to the split dosing regimens as are known in the art.
EXAMPLES
Example 1: Material and Methods
[0748] In Vitro Transcription Protocol
[0749] The mRNAs were synthesized in vitro using T7RNA polymerase-mediated DNA-dependent RNA transcription where uridine triphosphate (UTP) was substituted and unsubstituted with modified UTPs such as 5 methoxy UTP (5MeOU), N1-methoxy methyl pseudo UTP (N1-MOM), 5-hydroxy methyl UTP, 5-carboxy UTP, and mixture of modifications using linearized template for each UTR combination. The mRNA was purified using column chromatography, the DNA and double stranded mRNA contamination of all mRNAs was removed using an enzymatic reaction, and the mRNA was concentrated, and buffer exchanged.
[0750] Preparation of Lipid Encapsulated mRNA
[0751] Lipid encapsulated mRNA particles were prepared by mixing lipids (ATX lipid: DSPC: Cholesterol: PEG-DMG) in ethanol with mRNA encoding the desired therapeutic polypeptide dissolved in Citrate buffer. The mixed material was instantaneously diluted with Phosphate Buffer. Ethanol was removed by dialysis against phosphate buffer using regenerated cellulose membrane (100 kD MWCO) or by tangential flow filtration (TFF) using modified polyethersulfone (mPES) hollow fiber membranes (100 kD MWCO). Once the ethanol was completely removed, the buffer was exchanged with HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) buffer containing 50 mM NaCl and 9% sucrose, pH 7.3. The formulation was concentrated followed by 0.2 μm filtration using PES filters. The mRNA concentration in the formulation was then measured by Ribogreen fluorimetric assay following which the concentration was adjusted to a final desired concentration by diluting with HEPES buffer containing 50 mM NaCl, 9% sucrose, pH 7.3 containing glycerol. The final formulation was then filtered through a 0.2 μm filter and filled into glass vials, stoppered, capped and placed at −70±5° C. The frozen formulations were characterized for their mRNA content and percent encapsulation by Ribogreen assay, mRNA integrity by fragment analyzer, lipid content by high performance liquid chromatography (HPLC), particle size by dynamic light scattering on a Malvern Zetasizer Nano ZS, pH and Osmolality.
In-Cell Western (ICW)
[0752] 96-well collagen plates were used to seed the cells at the appropriate density in Dulbecco's Modified Eagle Media (DMEM)/Fetal Bovine Serum (FBS) culture media. At the optimal confluence, cells were transfected with the targeted mRNAs diluted in the transfection reagent mix (MessengerMax and Opti-MEM). Cells were placed in the CO2 incubator and allowed to grow. At the desire timepoint, media was removed, and cells were fixed in 4% fresh paraformaldehyde (PFA) for 20 min. After that, fixative was removed, and cells were permeabilize in tris buffered saline with TWEEN (TBST) for 5 min several times. When permeabilization washes were complete, cells were incubated with a blocking buffer (ODYSSEY@ Blocking Buffer (PBS) (Li-Cor, Lincoln, Nebr.)) for 45 min. Primary antibody was then added and incubated for 1 h at room temperature. Cells were then washed several times in TBST and incubated for 1 h with a secondary antibody diluted in blocking buffer and containing a CellTag 700 stain. To finalize, cells were washed several times in TBST followed by a last wash in tris-buffered saline (TBS). The plate was imaged using the Licor detection system and data was normalized to the total number of cells labeled by the CellTag 700.
Example 2: UTRs Screening in Hepa1,6 and Hep3B—Correlation at 24 h and 48 h
[0753] A UTR library was screened in vitro using mRNA construct #571 comprising the sequence of SEQ ID NO: 34, which relates to OTC, as CDS (coding sequence). In-Cell Western assays as described in Example 1 were used to transfect the different mRNAs into Hepa1,6 and Hep3B using commercially available transfection reagents. OTC protein expression levels were measured by near-infrared fluorescent imaging systems. Commercially available antibodies for OTC were used for detection. Untransfected and reference sequences were used as internal controls.
Example 3: Round 1 of Protein Stability Compounds Screened in Hepa1,6 and Hep3B at 24 h—Correlation
[0754] In vitro screening of certain mRNA constructs of Table 5 that were designed based on a protein-stability approach was performed. The mRNA constructs were tested in two different chemistries N1-methylpseudouridine (N1MPU) and 5-methoxyuridine (5MeOU) meaning that 100% of the uridines in each mRNA were N1MPU only or 5MeOU only (not a combination of 5MeOU or N1MPU). In-Cell Western (ICW) assays as described in Example 1 were used to transfect the different mRNAs into Hepa1,6 and Hep3B using commercially available transfection reagents. OTC protein expression levels were measured by near-infrared fluorescent imaging systems. Commercially available antibodies for OTC were used for detection. Untransfected and reference sequences were used as internal controls.
Example 4: Round 2 of Protein Stability Compounds Screened in Human Primary Hepatocytes at 24 h and 48 h—Correlation
[0755] In vitro screening of certain mRNA constructs of Table 5 that were designed based on a protein stability approach was performed. The mRNAs were tested in two different chemistries, 100% of the Uridines are N1MPU indicated by the name of mRNA constructs followed by “0.1” and 100% of the uridines are 5MeOU indicated by the name of mRNA constructs followed by “0.7”. In-Cell Western (ICW) assays as described in Example 1 were used to transfect the different mRNAs into human primary hepatocytes using commercially available transfection reagents. OTC protein expression levels were measured by near-infrared fluorescent imaging systems. Commercially available antibodies for OTC were used for detection. Untransfected and reference sequences were used as internal controls. (
Example 5: Round 3 of Protein Stability Compounds Screening in Human Primary Hepatocytes at 24 h and 48 h—Correlation
[0756] In vitro screening of novel compounds designed based on a protein stability approach was performed. mRNAs were tested in two different chemistries, N1MPU indicated by the name of mRNA constructs followed by “0.1” and 5MeOU indicated by the name of mRNA constructs followed by “0.7”. In-Cell Western (ICW) assays as described in Example 1 were used to transfect the different mRNAs into human primary hepatocytes using commercially-available transfection reagents. OTC protein expression levels were measured by near-infrared fluorescent imaging systems. Commercially available antibodies for OTC protein were used for detection. Untransfected and reference sequences were used as internal controls. (
Example 6: OTC Protein-Expression Levels in Human Primary Cells Transfected with OTC mRNA Constructs 1799.7 (5MeOU Chemistry) Encoding the OTC Protein of SEQ ID NO: 3 and 1921.7 (5MeOU Chemistry) Encoding the Modified OTC Protein of SEQ ID NO: 4
[0757] In-Cell Western (ICW) assays as described in Example 1 were used to transfect OTC mRNAs into human primary hepatocytes using commercially available transfection reagents. OTC protein expression levels were measured by near-infrared fluorescent imaging systems during a time course study up to 96 h. Commercially available OTC antibodies were used for detection. Untransfected cells were used as internal control. Plot shows OTC protein levels normalized to untransfected controls. (
Example 7: OTC Expression Levels Measured by Multiple Reaction Monitoring (MRM) Mass Spectrometry in Spf/Ash Mice Dosed at 10 mg/kg
[0758] Spf/ash mice received an IV injection with either PBS or lipid-formulated OTC-mRNAs at a 10 mg/kg dosing. WT mice were used as internal controls to determine endogenous levels. A time course (6 h, 24 h and 48 h) was performed, and expression levels were measured by MRM using human and mouse specific epitopes for OTC. Graphs were made that represent the amount of protein (ng/mg tissue) detected by MRM specific for human OTC (
Example 8: OTC Expression Levels Measured by Western Blot in WT Mice Dosed at 3 mg/kg
[0759] Spf/ash mice received an IV injection with either phosphate buffered saline (PBS) or lipid-formulated OTC-mRNAs at a 3 mg/kg dosing using two different chemistries (N1MPU and 5MeOU). WT mice were used as internal controls to determine endogenous levels. Animals were sacrificed 24 h post-dose. OTC expression levels were measured by Western Blot (WB) using an OTC specific antibody. In the results provided in
Example 9: OTC Expression Levels Measured by MRM in a Dose Range Finding Study
[0760] Balb/c mice received an IV injection with either PBS or lipid-formulated OTC-mRNAs at three different doses: 0.3 mg/kg, 1 mg/kg and 3 mg/kg and using two different chemistries (N1MPU and 5MeOU). Animals were sacrificed 24 h post-dose and expression levels were measured by MRM using human and mouse specific epitopes for OTC. The graph in
Example 10: Urinary Orotate Levels Measured in PBS and Treated Spf/Ash Mice
[0761] Spf/ash mice received an IV injection with either PBS or lipid-formulated OTC-mRNA construct 1799.7 (5MeOU chemistry) at three different doses: 0.3 mg/kg, 1 mg/kg and 3 mg/kg. WT and spf/ash mice were used to determine baseline and high urinary orotate levels, respectively. A Spf/ash time course was determined, and urinary orotate levels were measured at each timepoint. The results can be seen in
Example 11: Pharmacokinetic/Pharmacodynamic (PK/PD) Analysis Comparing Human OTC Expression Levels and Urinary Orotate at 96 h
[0762] Spf/ash mice received an IV injection with either PBS or certain lipid-formulated OTC-mRNAs from Table 5 at 1 mg/kg and 3 mg/kg using two different chemistries (N1MPU and 5MeOU). WT mice were used as internal controls. Human-specific OTC levels were measured by MRM whereas urinary orotate was determined in each sample and normalized to creatinine. PK/PD is plotted in
Example 12: Fractioning of Spf/Ash Mice In Vivo Samples Treated with Selected mRNAs
[0763] Spf/ash mice received an IV injection with either PBS or lipid-formulated OTC-mRNAs at 1 mg/kg and 3 mg/kg. WT mice were used as internal controls. Sample fractioning was performed on the liver samples, separating a cytosolic and a mitochondrial fraction. OTC levels were measured by WB using human specific (hOTC) and crossreactive (crOTC) antibodies (
Example 13: Plot of the Mitochondrial Vs Cytosolic Fractions of Spf/Ash Mice Samples Treated with mRNA Constructs 2016 and 2260
[0764] Spf/ash mice received an IV injection with either PBS or lipid-formulated OTC-mRNAs at 3 mg/kg. WT mice were used as internal controls. Sample fractioning was performed on the liver samples, separating a cytosolic and a mitochondrial fraction. OTC levels were measured by western blot using a human specific antibody. OTC protein expression levels were measured by near-infrared fluorescent imaging systems and both fractions normalized to total protein were plotted (
[0765] The patent and scientific literature referred to herein establishes the knowledge that is available to those with skill in the art. All United States patents and published or unpublished United States patent applications cited herein are incorporated by reference. All published foreign patents and patent applications cited herein are hereby incorporated by reference. All other published references, documents, manuscripts and scientific literature cited herein are hereby incorporated by reference.
[0766] While this disclosure has been particularly shown and described with references to preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the disclosure encompassed by the appended claims. It should also be understood that the embodiments described herein are not mutually exclusive and that features from the various embodiments may be combined in whole or in part in accordance with the disclosure.
TABLE-US-00007 SEQUENCE LISTING mRNA coding sequence for wild type human OTC (SEQ ID NO: 1) AUGCUGUUUAAUCUGAGGAUCCUGUUAAACAAUGCAGCUUUUAGAAAUGGU CACAACUUCAUGGUUCGAAAUUUUCGGUGUGGACAACCACUACAAAAUAAAG UGCAGCUGAAGGGCCGUGACCUUCUCACUCUAAAAAAC UUUACCGGAGAAGAAAUUAAAUAUAUGCUAUGGCUAUCAGCAGAUCUGAAA UUUAGGAUAAAACAGAAAGGAGAGUAUUUGCCUUUAUUGCAAGGGAAGUCC UUAGGCAUGAUUUUUGAGAAAAGAAGUACUCGAACAAGAUUGUCUACAGAA ACAGGCUUUGCACUUCUGGGAGGACAUCCUUGUUUUCUUACCACACAAGAUA UUCAUUUGGGUGUGAAUGAAAGUCUCACGGACACGGCCCGUGUAUUGUCUAG CAUGGCAGAUGCAGUAUUGGCUCGAGUGUAUAAACAAUCAGAUUUGGACACC CUGGCUAAAGAAGCAUCCAUCCCAAUUAUCAAUGGGCUGUCAGAUUUGUACC AUCCUAUCCAGAUCCUGGCUGAUUACCUCACGCUCCAGGAACACUAUAGCUC UCUGAAAGGUCUUACCCUCAGCUGGAUCGGGGAUGGGAACAAUAUCCUGCAC UCCAUCAUGAUGAGCGCAGCGAAAUUCGGAAUGCACCUUCAGGCAGCUACUC CAAAGGGUUAUGAGCCGGAUGCUAGUGUAACCAAGUUGGCAGAGCAGUAUG CCAAAGAGAAUGGUACCAAGCUGUUGCUGACAAAUGAUCCAUUGGAAGCAGC GCAUGGAGGCAAUGUAUUAAUUACAGACACUUGGAUAAGCAUGGGACAAGA AGAGGAGAAGAAAAAGCGGCUCCAGGCUUUCCAAGGUUACCAGGUUACAAUG AAGACUGCUAAAGUUGCUGCCUCUGACUGGACAUUUUUACACUGCUUGCCCA GAAAGCCAGAAGAAGUGGAUGAUGAAGUCUUUUAUUCUCCUCGAUCACUAG UGUUCCCAGAGGCAGAAAACAGAAAGUGGACAAUCAUGGCUGUCAUGGUGUC CCUGCUGACAGAUUACUCACCUCAGCUCCAGAAGCCUAAAUUUUGA DNA coding sequence for wild type human OTC (SEQ ID NO: 2) ATGCTGTTTAATCTGAGGATCCTGTTAAACAATGCAGCTTTTAGAAATGGTCAC AACTTCATGGTTCGAAATTTTCGGTGTGGACAACCACTACAAAATAAAGTGCAG CTGAAGGGCCGTGACCTTCTCACTCTAAAAAACTTTACCGGAGAAGAAATTAAA TATATGCTATGGCTATCAGCAGATCTGAAATTTAGGATAAAACAGAAAGGAGA GTATTTGCCTTTATTGCAAGGGAAGTCCTTAGGCATGATTTTTGAGAAAAGAAG TACTCGAACAAGATTGTCTACAGAAACAGGCTTTGCACTTCTGGGAGGACATCC TTGTTTTCTTACCACACAAGATATTCATTTGGGTGTGAATGAAAGTCTCACGGA CACGGCCCGTGTATTGTCTAGCATGGCAGATGCAGTATTGGCTCGAGTGTATAA ACAATCAGATTTGGACACCCTGGCTAAAGAAGCATCCATCCCAATTATCAATGG GCTGTCAGATTTGTACCATCCTATCCAGATCCTGGCTGATTACCTCACGCTCCAG GAACACTATAGCTCTCTGAAAGGTCTTACCCTCAGCTGGATCGGGGATGGGAAC AATATCCTGCACTCCATCATGATGAGCGCAGCGAAATTCGGAATGCACCTTCAG GCAGCTACTCCAAAGGGTTATGAGCCGGATGCTAGTGTAACCAAGTTGGCAGA GCAGTATGCCAAAGAGAATGGTACCAAGCTGTTGCTGACAAATGATCCATTGG AAGCAGCGCATGGAGGCAATGTATTAATTACAGACACTTGGATAAGCATGGGA CAAGAAGAGGAGAAGAAAAAGCGGCTCCAGGCTTTCCAAGGTTACCAGGTTAC AATGAAGACTGCTAAAGTTGCTGCCTCTGACTGGACATTTTTACACTGCTTGCC CAGAAAGCCAGAAGAAGTGGATGATGAAGTCTTTTATTCTCCTCGATCACTAGT GTTCCCAGAGGCAGAAAACAGAAAGTGGACAATCATGGCTGTCATGGTGTCCC TGCTGACAGATTACTCACCTCAGCTCCAGAAGCCTAAATTTTGA Human wild type OTC amino acid sequence (The signal peptide for mitochondrial import is underlined*) (SEQ ID NO: 3) MLFNLRILLNNAAFRNGHNFMVRNFRCGQPLQNKVQLKGRDLLTLKNFTGEEI KYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFALLGGHPC FLTTQDIHLGVNESLTDTARVLSSMADAVLARVYKQSDLDTLAKEASIPIF GLSDLYHPIQILADYLTLQEHYSSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQA ATPKGYEPDASVTKLAEQYAKENGTKLLLTNDPLEAAHGGNVLITDTWISMGQEE EKKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEA ENRKWTIMAVMVSLLTDYSPQLQKPKF Modified OTC amino acid sequence (The signal peptide for mitochondrial import is underlined*) (SEQ ID NO: 4) MLVFNLRILLNNAAFRNGHNFMVRNFRCGQPLQNRVQLKGRDLLTLKNFTGEEI RYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFALLGGHPC FLTTQDIHLGVNESLTDTARVLSSMADAVLARVYKQSDLDTLAKEASIPIINGLSDL YHPIQILADYLTLQEHYSSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQAATPKG YEPDASVTKLAEQYAKENGTKLLLTNDPLEAAHGGNVLITDTWISMGQEEEKKKR LQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKW TIMAVMVSLLTDYSPQLQKPKF TEV (SEQ ID NO: 5) TCAACACAACATATACAAAACAAACGAATCTCAAGCAATCAAGCATTCTACTTC TATTGCAGCAATTTAAATCATTTCTTTTAAAGCAAAAGCAATTTTCTGAAAATTT TCACCATTTACGAACGATAG AT1G58420 (SEQ ID NO: 6) ATTATTACATCAAAACAAAAAGCCGCCA ARC5-2 (SEQ ID NO: 7) CTTAAGGGGGCGCTGCCTACGGAGGTGGCAGCCATCTCCTTCTCGGCATCAAGC TTACCATGGTGCCCCAGGCCCTGCTCTTgGTCCCGCTGCTGGTGTTCCCCCTCTG CTTCGGCAAGTTCCCCATCTACACCATCCCCGACAAGCTGGGGCCGTGGAGCCC CATCGACATCCACCACCTGTCCTGCCCCAACAACCTCGTGGTCGAGGACGAGGG CTGCACCAACCTGAGCGGGTTCTCCTAC HCV (SEQ ID NO: 8) TGAGTGTCGT ACAGCCTCCA GGCCCCCCCC TCCCGGGAGA GCCATAGTGG TCTGCGGAACCGGTGAGTAC ACCGGAATTG CCGGGAAGAC TGGGTCCTTT CTTGGATAAA CCCACTCTATGCCCGGCCAT TTGGGCGTGC CCCCGCAAGA CTGCTAGCCG AGTAGTGTTG GGTTGCG HUMAN ALBUMIN (SEQ ID NO: 9) AATTATTGGTTAAAGAAGTATATTAGTGCTAATTTCCCTCCGTTTGTCCTAGCTT TTCTCTTCTGTCAACCCCACACGCCTTTGGCACA EMCV (SEQ ID NO: 10) CTCCCTCCCC CCCCCCTAAC GTTACTGGCC GAAGCCGCTT GGAATAAGGC CGGTGTGCGT TTGTCTATAT GTTATTTTCC ACCATATTGC CGTCTTTTGG CAATGTGAGG GCCCGGAAAC CTGGCCCTGT CTTCTTGACG AGCATTCCTA GGGGTCTTTC CCCTCTCGCC AAAGGAATGC AAGGTCTGTT GAATGTCGTG AAGGAAGCAG TTCCTCTGGA AGCTTCTTGA AGACAAACAA CGTCTGTAGC GACCCTTTGC AGGCAGCGGA ACCCCCCACC TGGCGACAGG TGCCTCTGCG GCCAAAAGCC ACGTGTATAA GATACACCTG CAAAGGCGGC ACAACCCCAG TGCCACGTTG TGAGTTGGAT AGTTGTGGAA AGAGTCAAAT GGCTCTCCTC AAGCGTATTC AACAAGGGGC TGAAGGATGC CCAGAAGGTA CCCCATTGTA TGGGATCTGA TCTGGGGCCT CGGTGCACAT GCTTTACGTG TGTTTAGTCG AGGTTAAAAA ACGTCTAGGC CCCCCGAACC ACGGGGACGT GGTTTTCCTT TGAAAAACAC GATGATAAT HSP70-P2 (SEQ ID NO: 11) GTCAGCTTTCAAACTCTTTGTTTCTTGTTTGTTGATTGAGAATA HSP70-M1 (SEQ ID NO: 12) CTCTCGCCTGAGAAAAAAAATCCACGAACCAATTTCTCAGCAACCAGCAGCAC G HSP72-M2 (SEQ ID NO: 13) ACCTGTGAGGGTTCGAAGGAAGTAGCAGTGTTTTTTGTTCCTAGAGGAAGAG HSP17.9 (SEQ ID NO: 14) ACACAGAAACATTCGCAAAAACAAAATCCCAGTATCAAAATTCTTCTCTTTTTT TCATATTTCGCAAAGAC HSP70-P1 (SEQ ID NO: 15) CAGAAAAATTTGCTACATTGTTTCACAAACTTCAAATATTATTCATTTATTT XBG (SEQ ID NO: 16) CTAGTGACTGACTAGGATCTGGTTACCACTAAACCAGCCTCAAGAACACCCGAA TGGAGTCTCTAAGCTACATAATACCAACTTACACTTACAAAATGTTGTCCCCCA AAATGTAGCCATTCGTATCTGCTCCTAATAAAAAGAAAGTTTCTTCACAT HUMAN HAPTOGLOBIN (SEQ ID NO: 17) TGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTGGAAGAG GGCAAAGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAG CTGATGGGTGCCAGCCCTGCATTGCTGAGTCAATCAATAAAGAGCTTTCTTTTG ACCCAT HUMAN APOLIPOPROTEIN E (SEQ ID NO: 18) ACGCCGAAGCCTGCAGCCATGCGACCCCACGCCACCCCGTGCCTCCTGCCTCCG CGCAGCCTGCAGCGGGAGACCCTGTCCCCGCCCCAGCCGTCCTCCTGGGGTGGA CCCTAGTTTAATAAAGATTCACCAAGTTTCACGCA HCV (SEQ ID NO: 19) TAGAGCGGCAAACCCTAGCTACACTCCATAGCTAGTTTCTTTTTTTTTTGTTTTTT TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCCTTTCTTTTCCTTCTTTTTTTCCTC TTTTCTTGGTGGCTCCATCTTAGCCCTAGTCACGGCTAGCTGTGAAAGGTCCGTG AGCCGCATGACTGCAGAGAGTGCCGTAACTGGTCTCTCTGCAGATCATGT MOUSE ALBUMIN (SEQ ID NO: 20) ACACATCACAACCACAACCTTCTCAGGCTACCCTGAGAAAAAAAGACATGAAG ACTCAGGACTCATCTTTTCTGTTGGTGTAAAATCAACACCCTAAGGAACACAAA TTTCTTTAAACATTTGACTTCTTGTCTCTGTGCTGCAATTAATAAAAAATGGAAA GAATCTAC HUMAN ALPHA GLOBIN (SEQ ID NO: 21) GCTGGAGCCTCGGTAGCCGTTCCTCCTGCCCGCTGGGCCTCCCAACGGGCCCTC CTCCCCTCCTTGCACCGGCCCTTCCTGGTCTTTGAATAAAGTCTGAGTGGGCAGC A EMCV (SEQ ID NO: 22) TAGTGCAGTCAC TGGCACAACG CGTTGCCCGG TAAGCCAATC GGGTATACAC GGTCGTCATACTGCAGACAG GGTTCTTCTA CTTTGCAAGA TAGTCTAGAG TAGTAAAATA AATAGTATAAG (SEQ ID NO: 23) GCCACC (SEQ ID NO: 24) GCCA (SEQ ID NO: 25) AUAAGUGAA >mARM563 (SEQ ID NO: 26) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGUUUAAUCUGAGGAUC CUGUUAAACAAUGCAGCUUUUAGAAAUGGUCACAACUUCAUGGUUCGAAAU UUUCGGUGUGGACAACCACUACAAAAUAAAGUGCAGCUGAAGGGCCGUGACC UUCUCACUCUAAAAAACUUUACCGGAGAAGAAAUUAAAUAUAUGCUAUGGC UAUCAGCAGAUCUGAAAUUUAGGAUAAAACAGAAAGGAGAGUAUUUGCCUU UAUUGCAAGGGAAGUCCUUAGGCAUGAUUUUUGAGAAAAGAAGUACUCGAA CAAGAUUGUCUACAGAAACAGGCUUUGCACUUCUGGGAGGACAUCCUUGUUU UCUUACCACACAAGAUAUUCAUUUGGGUGUGAAUGAAAGUCUCACGGACACG GCCCGUGUAUUGUCUAGCAUGGCAGAUGCAGUAUUGGCUCGAGUGUAUAAAC AAUCAGAUUUGGACACCCUGGCUAAAGAAGCAUCCAUCCCAAUUAUCAAUGG GCUGUCAGAUUUGUACCAUCCUAUCCAGAUCCUGGCUGAUUACCUCACGCUC CAGGAACACUAUAGCUCUCUGAAAGGUCUUACCCUCAGCUGGAUCGGGGAUG GGAACAAUAUCCUGCACUCCAUCAUGAUGAGCGCAGCGAAAUUCGGAAUGCA CCUUCAGGCAGCUACUCCAAAGGGUUAUGAGCCGGAUGCUAGUGUAACCAAG UUGGCAGAGCAGUAUGCCAAAGAGAAUGGUACCAAGCUGUUGCUGACAAAU GAUCCAUUGGAAGCAGCGCAUGGAGGCAAUGUAUUAAUUACAGACACUUGG AUAAGCAUGGGACAAGAAGAGGAGAAGAAAAAGCGGCUCCAGGCUUUCCAA GGUUACCAGGUUACAAUGAAGACUGCUAAAGUUGCUGCCUCUGACUGGACAU UUUUACACUGCUUGCCCAGAAAGCCAGAAGAAGUGGAUGAUGAAGUCUUUU AUUCUCCUCGAUCACUAGUGUUCCCAGAGGCAGAAAACAGAAAGUGGACAAU CAUGGCUGUCAUGGUGUCCCUGCUGACAGAUUACUCACCUCAGCUCCAGAAG CCUAAAUUUUGACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAAC CAGCCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUAC ACUUACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUA AAAAGAAAGUUUCUUCACAUUCUAG >mARM564 (SEQ ID NO: 27) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUCUUUAAUCUGCGCAUC UUACUGAACAACGCCGCAUUCCGGAACGGUCACAACUUCAUGGUCCGCAAUU UCCGCUGUGGCCAGCCGCUUCAAAACAAGGUCCAGCUGAAGGGACGGGAUCU GCUGACACUGAAGAACUUCACCGGAGAAGAGAUCAAGUACAUGCUGUGGCUC AGCGCAGACUUGAAGUUCCGGAUCAAGCAGAAGGGAGAAUACUUGCCCCUGC UGCAAGGAAAGUCGCUGGGAAUGAUUUUUGAGAAGCGGUCAACUCGCACCAG ACUCUCCACCGAAACUGGUUUCGCACUGCUUGGCGGGCACCCUUGCUUCCUG ACGACUCAGGACAUCCACCUCGGCGUGAACGAAUCGCUAACCGAUACCGCCA GAGUGCUUUCUUCCAUGGCCGACGCGGUGCUGGCCAGGGUGUACAAGCAGUC CGACCUCGAUACCUUGGCAAAGGAGGCUUCCAUUCCCAUCAUCAACGGCCUG AGCGACCUGUACCACCCAAUCCAAAUCCUGGCUGACUACCUGACCCUGCAAG AGCACUACAGCAGCCUGAAGGGUCUGACCCUGUCAUGGAUUGGCGAUGGAAA CAAUAUUCUGCACUCCAUCAUGAUGUCCGCCGCGAAGUUCGGAAUGCAUCUG CAAGCCGCCACUCCAAAAGGAUACGAACCGGAUGCGUCCGUGACCAAGUUGG CGGAACAGUACGCGAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC CCUCGAGGCUGCGCAUGGGGGCAACGUGCUGAUUACCGACACCUGGAUCUCC AUGGGGCAGGAGGAAGAGAAGAAGAAGAGACUGCAGGCAUUCCAGGGGUAC CAGGUCACCAUGAAAACCGCAAAAGUGGCAGCUUCGGACUGGACUUUCCUGC AUUGCCUGCCGAGGAAGCCGGAGGAAGUCGACGACGAAGUGUUCUACUCGCC UCGGUCCCUGGUGUUCCCCGAGGCCGAAAACCGGAAGUGGACCAUCAUGGCC GUGAUGGUGUCCUUGCUGACUGACUAUAGCCCGCAGCUGCAGAAGCCUAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM565 (SEQ ID NO: 28) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGUUUAACCUACGUAUU UUGCUCAACAAUGCAGCCUUUAGAAACGGACAUAACUUUAUGGUUCGAAACU UUCGCUGCGGGCAGCCACUGCAGAACAAGGUCCAGCUGAAAGGGAGAGAUUU GCUCACGCUGAAGAACUUUACUGGCGAAGAAAUCAAGUAUAUGCUGUGGUU GUCCGCGGACCUCAAGUUUCGGAUUAAGCAGAAAGGGGAGUAUCUGCCACUG CUGCAAGGAAAGAGCCUCGGCAUGAUCUUCGAGAAGCGGAGCACUCGGACCA GGCUGAGUACCGAAACUGGCUUCGCAUUGUUGGGUGGACAUCCAUGUUUUCU GACAACGCAGGACAUUCAUCUGGGCGUGAACGAGAGUCUGACGGACACAGCU CGCGUUCUGUCCUCUAUGGCUGAUGCGGUGUUGGCCCGGGUCUAUAAGCAGU CCGAUUUGGACACCUUGGCUAAGGAAGCUAGCAUACCGAUUAUCAAUGGGCU GUCCGACCUGUAUCACCCUAUUCAAAUCCUGGCCGACUACCUCACACUGCAA GAACACUAUAGCUCAUUGAAGGGACUGACCCUGAGCUGGAUAGGGGACGGAA ACAACAUCCUACAUAGCAUUAUGAUGUCCGCUGCCAAGUUUGGCAUGCAUCU UCAAGCCGCCACGCCAAAGGGUUAUGAGCCCGACGCGUCAGUGACAAAGCUG GCCGAGCAGUACGCUAAGGAGAAUGGUACCAAAUUACUGCUGACUAAUGAUC CACUGGAGGCUGCACAUGGCGGCAAUGUACUGAUCACCGACACAUGGAUCUC GAUGGGCCAGGAGGAAGAAAAGAAGAAGAGGCUUCAGGCCUUCCAAGGCUAC CAGGUCACCAUGAAAACAGCUAAGGUUGCAGCAUCUGAUUGGACCUUUCUGC ACUGUCUGCCAAGGAAGCCCGAAGAGGUGGACGAUGAAGUAUUCUAUAGCCC ACGGAGUUUGGUGUUCCCUGAGGCUGAAAAUAGGAAGUGGACAAUUAUGGC CGUAAUGGUGUCCCUGUUAACCGACUACUCUCCGCAACUGCAGAAACCUAAG UUUUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCU CAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUAC AAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGA AAGUUUCUUCACAUUCUAG >mARM566 (SEQ ID NO: 29) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGUUUAACUUAAGGAUC CUGCUGAACAACGCCGCUUUUCGUAACGGUCAUAACUUUAUGGUCCGGAACU UUAGAUGUGGCCAGCCGCUGCAGAACAAGGUUCAGCUGAAGGGGAGGGAUCU GCUGACCUUGAAGAACUUUACCGGCGAAGAGAUCAAGUACAUGUUGUGGCUG AGCGCCGAUCUGAAGUUUAGGAUUAAGCAGAAGGGGGAGUAUUUGCCACUG CUGCAAGGAAAAUCCUUGGGGAUGAUCUUCGAGAAGCGCUCCACUAGAACCC GGCUAAGCACAGAAACCGGCUUCGCACUUCUGGGUGGACAUCCCUGUUUUCU GACGACGCAGGAUAUACACCUGGGCGUGAAUGAGAGUCUGACGGACACAGCU AGGGUGUUGAGCAGCAUGGCCGAUGCAGUACUGGCCCGCGUUUAUAAGCAGA GCGACUUGGACACACUGGCCAAGGAAGCGUCAAUUCCGAUUAUCAAUGGGCU GUCAGACCUGUAUCAUCCCAUUCAAAUCUUGGCUGACUAUCUGACCCUGCAA GAACAUUACAGCUCCCUGAAGGGCCUCACGUUGUCCUGGAUUGGCGACGGAA ACAACAUUCUGCAUUCGAUCAUGAUGAGCGCUGCUAAGUUUGGCAUGCACCU CCAAGCCGCUACACCUAAGGGAUAUGAGCCUGAUGCCAGCGUAACCAAGCUG GCCGAACAGUACGCGAAGGAGAAUGGCACGAAACUGCUGUUGACAAAUGACC CACUGGAGGCAGCUCACGGUGGCAACGUGCUGAUCACCGACACGUGGAUAUC UAUGGGACAGGAAGAAGAGAAGAAGAAGCGGCUGCAGGCAUUCCAAGGGUA UCAGGUCACCAUGAAAACGGCCAAGGUUGCUGCAUCCGACUGGACAUUUCUG CAUUGCUUGCCCCGCAAACCAGAAGAAGUAGACGACGAAGUCUUUUAUUCCC CACGGUCGCUGGUGUUCCCCGAGGCGGAGAAUCGAAAGUGGACGAUUAUGGC CGUGAUGGUGUCCCUGCUGACUGAUUACUCUCCCCAACUGCAAAAGCCUAAG UUUUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCU CAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUAC AAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGA AAGUUUCUUCACAUUCUAG >mARM567 (SEQ ID NO: 30) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAACCUGAGGAUC CUCCUGAACAACGCCGCCUUUCGCAAUGGUCACAACUUUAUGGUCCGGAACU UCAGAUGCGGCCAGCCGCUGCAGAACAAGGUCCAGCUGAAGGGACGGGAUCU GCUGACUCUGAAGAACUUCACCGGAGAAGAGAUCAAGUACAUGCUGUGGCUG UCGGCCGACCUGAAGUUCAGGAUCAAGCAGAAGGGAGAAUACCUCCCGCUGC UGCAAGGAAAGUCCCUGGGCAUGAUUUUCGAGAAGCGCUCGACCAGAACUCG GUUGUCCACCGAAACCGGGUUUGCGCUGCUGGGCGGACAUCCUUGCUUCCUG ACGACUCAGGAUAUUCACCUGGGAGUGAACGAGUCGCUGACCGACACCGCCA GAGUGCUGAGCUCGAUGGCCGACGCCGUGUUGGCACGCGUGUACAAGCAGUC CGAUCUGGAUACCCUGGCCAAAGAAGCUUCCAUCCCGAUCAUUAACGGGCUG AGCGACCUCUACCACCCCAUUCAAAUCCUGGCCGACUACCUGACUCUGCAAG AACACUACAGCUCGCUGAAGGGGUUGACUCUGUCCUGGAUCGGCGACGGAAA CAACAUCCUGCACUCCAUCAUGAUGUCGGCCGCAAAGUUCGGCAUGCAUUUG CAAGCCGCCACCCCAAAGGGCUACGAACCAGACGCGAGCGUCACCAAGCUGG CCGAACAGUACGCGAAGGAAAAUGGUACUAAGCUGCUGCUGACCAACGACCC AUUGGAAGCUGCCCAUGGUGGAAACGUGCUGAUCACCGACACCUGGAUCUCG AUGGGCCAGGAAGAGGAGAAGAAGAAGCGGCUGCAGGCGUUCCAGGGGUAU CAGGUCACCAUGAAAACAGCCAAAGUGGCAGCGUCAGACUGGACCUUCCUCC ACUGUCUGCCUCGCAAGCCAGAGGAGGUGGACGACGAGGUGUUCUACUCCCC UCGGUCCCUCGUGUUCCCUGAGGCUGAGAACCGGAAGUGGACCAUUAUGGCC GUGAUGGUGUCACUCCUGACUGAUUACUCCCCGCAACUGCAGAAGCCCAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM568 (SEQ ID NO: 31) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGUUUAACCUGAGGAUC CUAUUGAACAAUGCUGCUUUUCGUAAUGGCCAUAACUUUAUGGUUCGGAACU UUAGAUGCGGGCAGCCACUGCAGAACAAGGUCCAGUUGAAAGGCCGCGAUCU GUUGACAUUGAAGAACUUUACCGGCGAAGAGAUUAAGUAUAUGCUGUGGCU GUCUGCUGACCUCAAGUUUCGAAUCAAGCAGAAGGGCGAAUAUCUCCCCCUG CUGCAAGGAAAGUCUCUCGGCAUGAUCUUUGAGAAGCGGAGUACCCGAACAC GGCUGAGCACCGAAACGGGCUUCGCACUGCUGGGGGGCCAUCCCUGUUUUCU GACAACGCAGGACAUCCACUUGGGGGUUAACGAAUCAUUGACUGAUACCGCC CGCGUACUGUCAUCCAUGGCCGACGCUGUGCUGGCUAGGGUGUACAAGCAGU CAGAUCUGGAUACACUGGCCAAGGAAGCUAGCAUACCAAUCAUCAAUGGACU GAGUGACCUUUAUCACCCGAUUCAAAUACUAGCCGAUUAUCUGACCCUGCAA GAGCAUUACUCCUCGCUGAAAGGCCUCACGCUGUCCUGGAUCGGCGACGGCA ACAACAUUCUGCAUAGUAUUAUGAUGUCUGCUGCCAAAUUCGGCAUGCAUCU GCAAGCUGCUACGCCGAAGGGUUAUGAACCCGACGCGUCAGUUACGAAGCUC GCUGAGCAGUAUGCAAAGGAGAAUGGCACAAAGCUGUUGCUUACCAACGAUC CCCUGGAAGCUGCUCAUGGCGGCAAUGUGCUGAUUACUGACACCUGGAUUUC AAUGGGCCAGGAGGAGGAGAAGAAGAAGAGGUUACAGGCUUUUCAAGGUUA CCAAGUCACGAUGAAAACCGCUAAGGUCGCAGCCAGCGACUGGACAUUCCUG CACUGUCUGCCAAGAAAGCCGGAAGAAGUGGACGACGAGGUGUUCUAUUCCC CGCGGUCUUUGGUGUUUCCGGAGGCCGAAAACAGGAAAUGGACCAUUAUGGC CGUGAUGGUAUCGUUGCUGACGGACUACAGCCCUCAGUUGCAAAAGCCCAAG UUCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCU CAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUAC AAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGA AAGUUUCUUCACAUUCUAG >mARM569 (SEQ ID NO: 32) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUCUUUAACCUCCGCAUC CUCCUCAACAACGCCGCCUUCCGGAAUGGGCAUAACUUCAUGGUCCGGAACU UCAGAUGCGGCCAGCCCCUGCAAAACAAGGUCCAGUUGAAGGGACGGGACCU CCUUACGCUGAAGAACUUUACCGGAGAAGAGAUUAAGUACAUGCUGUGGUU GUCCGCUGACCUCAAGUUCCGCAUUAAGCAGAAGGGAGAAUAUCUGCCGCUG CUGCAAGGAAAGAGCCUGGGCAUGAUCUUCGAAAAGCGCUCCACUAGAACCC GGCUGUCGACUGAGACUGGAUUCGCCUUGCUCGGUGGACACCCGUGCUUCCU GACGACCCAGGACAUCCACCUGGGAGUGAACGAGUCACUUACGGAUACCGCG AGGGUGCUGUCCUCAAUGGCCGACGCAGUGCUCGCGCGCGUGUACAAGCAGU CAGAUCUGGAUACCCUGGCCAAGGAAGCCAGCAUUCCCAUCAUCAACGGACU GAGCGACCUUUACCACCCAAUCCAGAUCCUCGCCGACUACUUAACCCUGCAA GAGCACUACAGCUCCCUGAAGGGACUGACUCUGUCCUGGAUCGGGGAUGGAA ACAACAUCCUGCACUCCAUCAUGAUGUCUGCCGCUAAGUUUGGGAUGCAUCU GCAAGCCGCAACCCCUAAGGGAUACGAGCCCGACGCCUCGGUGACCAAACUU GCGGAACAGUACGCCAAGGAAAACGGUACCAAGCUGCUGCUGACCAACGACC CUCUGGAAGCGGCCCACGGAGGAAAUGUGCUGAUUACCGACACCUGGAUUUC GAUGGGCCAGGAGGAGGAGAAGAAGAAGAGACUGCAGGCGUUCCAGGGAUA UCAGGUCACCAUGAAAACCGCCAAGGUCGCCGCCAGCGACUGGACCUUCCUG CACUGUCUCCCUCGGAAACCGGAAGAAGUGGAUGACGAGGUGUUCUACUCCC CGCGCUCGCUGGUGUUCCCGGAGGCUGAAAACAGGAAGUGGACAAUCAUGGC CGUGAUGGUGUCCCUGUUGACCGACUACUCCCCACAACUGCAGAAGCCCAAG UUCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCU CAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUAC AAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGA AAGUUUCUUCACAUUCUAG >mARM570 (SEQ ID NO: 33) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAAUCUGCGCAUC CUCCUGAACAACGCCGCCUUCCGCAAUGGACACAACUUUAUGGUCCGCAACU UCCGCUGUGGGCAGCCGCUGCAGAACAAGGUCCAGCUCAAGGGGAGAGAUCU CCUGACCCUGAAGAACUUCACUGGAGAGGAGAUCAAGUACAUGCUGUGGCUG UCCGCCGACCUGAAAUUUCGGAUUAAGCAGAAGGGCGAAUACCUCCCACUGC UGCAAGGAAAGUCUUUGGGCAUGAUCUUCGAAAAGAGAAGCACCCGGACCCG GUUGAGCACCGAAACUGGGUUCGCGCUCCUCGGUGGACACCCGUGCUUCCUG ACCACCCAAGAUAUUCAUCUGGGUGUCAACGAAAGCCUGACCGACACCGCCA GGGUGCUGUCAUCCAUGGCUGACGCAGUGCUCGCCCGGGUGUACAAGCAGUC AGACCUGGACACCCUCGCCAAGGAAGCUUCGAUCCCUAUCAUCAACGGACUU UCCGACCUGUACCACCCCAUCCAAAUUCUGGCCGACUACCUGACUCUGCAAG AACACUAUAGCUCGCUGAAAGGACUUACUCUGUCCUGGAUCGGGGACGGCAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCUGCCAAGUUCGGAAUGCACCUU CAAGCAGCGACUCCCAAGGGAUACGAACCUGAUGCCUCCGUGACUAAGCUGG CAGAGCAGUACGCCAAGGAGAACGGUACAAAGCUGCUGCUCACGAACGACCC CCUGGAGGCGGCCCACGGCGGAAACGUGCUGAUUACCGAUACCUGGAUCUCA AUGGGCCAGGAAGAGGAGAAGAAGAAGCGGCUCCAGGCGUUUCAAGGCUACC AGGUCACCAUGAAAACCGCGAAGGUCGCCGCCUCCGACUGGACUUUCUUGCA CUGCCUGCCGCGGAAGCCCGAGGAAGUGGAUGACGAAGUGUUCUACUCGCCG AGAUCGUUGGUGUUCCCUGAGGCCGAAAACAGGAAGUGGACCAUCAUGGCCG UGAUGGUGUCCCUGCUGACUGAUUACAGCCCACAGCUGCAGAAGCCUAAGUU CUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUCA AGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACAA AAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAAA GUUUCUUCACAUUCUAG >mARM571 (SEQ ID NO: 34) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAAAACAAGGUCCAGCUGAAGGGCCGGGAUCU UCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGGCUC UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCC GGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGCCUU AGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGGCAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAUCUU CAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC ACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCUGC ACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC ACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM572 (SEQ ID NO: 35) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAACCUGAGAAUC CUCCUGAACAACGCCGCCUUCCGCAAUGGUCAUAACUUCAUGGUCCGCAACU UUCGCUGCGGACAGCCUCUCCAAAACAAGGUCCAGCUCAAGGGGCGCGACCU CCUCACACUGAAGAACUUCACUGGAGAAGAAAUCAAGUACAUGCUGUGGCUG AGCGCCGAUCUGAAGUUCCGGAUCAAGCAGAAGGGAGAGUACCUUCCUCUGC UGCAAGGGAAGUCCUUGGGAAUGAUUUUCGAGAAGCGGUCCACCCGGACCAG GCUGAGCACUGAAACUGGCUUCGCCCUGCUGGGAGGCCACCCUUGUUUCCUG ACCACUCAGGACAUCCACCUGGGCGUGAACGAGUCCCUGACCGAUACUGCCA GAGUGCUGUCCUCCAUGGCCGACGCCGUGCUCGCCCGGGUGUACAAGCAGUC AGACCUCGAUACGCUGGCCAAGGAAGCCUCCAUUCCCAUUAUCAAUGGUCUG UCGGACCUCUACCAUCCAAUCCAAAUCCUCGCCGACUACCUGACUCUGCAAG AACACUACAGCUCACUCAAGGGCCUCACCCUCUCCUGGAUCGGCGACGGAAA CAACAUCCUUCACUCGAUUAUGAUGUCGGCCGCGAAGUUCGGGAUGCACCUC CAAGCUGCCACUCCAAAAGGCUACGAGCCGGAUGCCUCAGUGACUAAGUUGG CGGAACAGUAUGCGAAGGAGAACGGUACCAAGCUCCUGCUGACUAACGACCC GCUGGAGGCCGCCCACGGGGGAAACGUGCUCAUCACCGAUACUUGGAUUUCC AUGGGACAGGAGGAAGAGAAGAAGAAGCGGUUGCAGGCAUUUCAGGGCUAC CAGGUCACCAUGAAAACUGCCAAAGUCGCCGCCAGCGACUGGACCUUCCUGC ACUGCCUGCCCCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCUCC CCGGUCCCUCGUGUUCCCUGAGGCCGAAAACAGGAAGUGGACCAUCAUGGCU GUGAUGGUGUCCCUCCUGACCGACUACAGCCCUCAGCUCCAAAAACCCAAGU UUUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM573 (SEQ ID NO: 36) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAACCUGAGAAUC CUCUUGAACAAUGCUGCUUUUCGGAAUGGCCACAACUUUAUGGUUCGGAACU UCCGUUGCGGCCAGCCUUUACAAAACAAGGUCCAGCUGAAGGGCCGGGAUUU GCUCACACUGAAGAACUUUACUGGGGAGGAGAUUAAGUAUAUGCUGUGGCU GUCCGCUGACCUGAAGUUUAGGAUCAAGCAGAAGGGCGAAUAUCUGCCGCUG CUGCAAGGGAAAAGUCUGGGCAUGAUUUUUGAAAAGCGCUCUACCCGGACCA GACUGUCUACGGAAACAGGCUUUGCCCUGCUGGGCGGCCACCCCUGUUUUCU GACAACGCAGGACAUCCAUCUGGGCGUGAACGAAUCACUGACCGAUACUGCU CGGGUACUCAGUUCUAUGGCUGACGCAGUGCUGGCUAGGGUGUACAAGCAGA GCGACUUGGACACACUGGCUAAGGAGGCCAGCAUCCCCAUUAUCAAUGGCCU GUCUGAUUUGUACCAUCCCAUUCAAAUCCUGGCUGAUUAUCUGACACUACAA GAGCAUUACUCAAGUCUGAAGGGUUUGACUCUCUCCUGGAUCGGCGACGGCA ACAACAUUUUACAUUCCAUUAUGAUGAGUGCUGCUAAGUUUGGCAUGCAUU UGCAAGCUGCUACCCCAAAGGGCUAUGAACCUGACGCUAGCGUAACCAAGUU GGCCGAACAGUAUGCUAAAGAGAAUGGCACCAAGCUGCUCCUGACGAAUGAC CCCCUGGAAGCUGCUCAUGGCGGAAACGUACUUAUAACUGAUACAUGGAUUA GCAUGGGCCAGGAAGAGGAGAAGAAGAAGAGACUGCAGGCCUUCCAAGGCUA UCAGGUCACCAUGAAAACUGCCAAGGUUGCAGCUAGCGACUGGACCUUCCUG CACUGUUUGCCGAGGAAACCCGAGGAGGUGGACGAUGAAGUCUUUUAUUCUC CCCGCUCCUUGGUGUUUCCCGAGGCUGAAAAUCGAAAGUGGACGAUAAUGGC AGUGAUGGUGUCCCUACUGACCGACUAUUCUCCACAACUGCAGAAGCCUAAA UUCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCU CAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUAC AAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGA AAGUUUCUUCACAUUCUAG >mARM574 (SEQ ID NO: 37) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAAUCUGAGGAUC CUGCUGAACAACGCUGCUUUUCGCAACGGUCAUAACUUUAUGGUUCGCAAUU UUCGUUGUGGCCAGCCGCUGCAGAACAAGGUUCAGCUGAAGGGCAGAGAUCU GCUGACUCUGAAGAACUUCACUGGGGAAGAAAUCAAGUAUAUGUUAUGGCU GUCCGCGGAUCUGAAAUUUCGAAUCAAGCAGAAGGGCGAAUAUCUUCCCCUG CUGCAAGGGAAAUCCUUGGGCAUGAUUUUUGAGAAGAGGAGCACUAGGACU AGAUUGUCAACAGAAACAGGCUUUGCUUUGUUGGGCGGACAUCCCUGCUUUC UGACGACACAGGAUAUCCACCUCGGCGUAAACGAGUCCCUCACCGACACUGC UAGGGUACUGAGCAGCAUGGCCGACGCUGUGCUAGCCCGGGUUUACAAGCAG UCAGACCUGGACACCCUUGCCAAGGAAGCUUCUAUUCCAAUUAUCAACGGCC UGAGUGACCUGUAUCACCCUAUUCAAAUACUCGCCGACUAUUUGACGCUUCA AGAACAUUACAGCAGCCUCAAGGGCUUAACCUUGAGUUGGAUAGGCGACGGC AACAAUAUCCUGCAUUCCAUUAUGAUGUCUGCCGCUAAGUUUGGCAUGCAUC UACAAGCCGCAACACCCAAGGGCUAUGAACCCGACGCUAGCGUGACCAAGCU GGCCGAGCAGUAUGCUAAGGAAAAUGGCACAAAGCUCCUUCUUACCAACGAU CCCCUGGAGGCUGCUCACGGCGGCAACGUGCUGAUUACCGAUACAUGGAUUA GCAUGGGCCAGGAGGAGGAGAAAAAGAAGCGGCUCCAGGCUUUUCAAGGCUA UCAGGUCACCAUGAAAACUGCAAAGGUCGCUGCCUCCGACUGGACUUUCCUG CAUUGUCUACCCCGCAAGCCUGAGGAAGUGGACGAUGAGGUGUUCUACUCCC CACGGAGUCUGGUGUUCCCGGAAGCAGAGAAUCGGAAGUGGACCAUCAUGGC UGUCAUGGUGUCGCUCUUGACUGACUAUUCUCCCCAACUGCAAAAACCCAAG UUUUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCU CAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUAC AAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGA AAGUUUCUUCACAUUCUAG >mARM575 (SEQ ID NO: 38) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGUUAUUCAACCUUCGUAUC CUGCUAAACAAUGCUGCUUUUCGCAAUGGCCAUAACUUUAUGGUUCGCAACU UUAGAUGCGGCCAGCCGCUGCAGAACAAGGUUCAGCUGAAGGGCCGGGACUU GCUGACGCUGAAAAACUUUACCGGGGAAGAGAUUAAGUAUAUGCUGUGGCU AAGCGCUGAUCUGAAGUUUAGGAUCAAGCAGAAGGGCGAAUAUCUGCCACUG CUGCAAGGGAAGAGUCUUGGCAUGAUUUUUGAAAAGCGGUCUACCAGAACCC GGCUGUCGACCGAGACAGGUUUUGCUCUGCUGGGGGGCCAUCCCUGUUUUCU GACAACUCAGGACAUUCACCUGGGCGUGAAUGAGUCCCUGACCGAUACUGCU AGGGUGUUGAGUAGCAUGGCCGACGCUGUACUCGCUCGAGUGUAUAAGCAGU CUGAUCUGGACACUCUGGCUAAGGAAGCUUCCAUUCCUAUUAUCAACGGCUU GAGCGACCUGUACCACCCCAUUCAAAUCCUCGCUGAUUACUUGACUUUGCAA GAACAUUACAGCAGCUUGAAGGGCUUAACACUGAGCUGGAUAGGCGACGGAA ACAACAUCUUGCAUUCCAUAAUGAUGUCCGCCGCUAAGUUCGGGAUGCACCU CCAAGCAGCCACACCCAAGGGCUAUGAACCGGAUGCUUCCGUGACAAAACUG GCUGAGCAGUAUGCUAAGGAGAAUGGCACGAAACUGCUGCUCACCAACGACC CAUUGGAAGCUGCACAUGGUGGCAACGUACUGAUCACUGACACUUGGAUCUC AAUGGGCCAGGAGGAAGAGAAGAAGAAAAGGCUGCAGGCAUUUCAGGGAUA CCAAGUCACUAUGAAAACUGCCAAGGUCGCUGCCUCCGACUGGACAUUCCUG CAUUGUCUGCCACGGAAGCCUGAGGAAGUCGAUGACGAAGUGUUCUAUAGCC CACGAAGCUUGGUGUUUCCCGAGGCUGAGAAUAGGAAGUGGACCAUUAUGGC UGUUAUGGUGUCCCUGCUCACCGACUAUUCCCCUCAACUGCAAAAACCCAAG UUUUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCU CAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUAC AAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGA AAGUUUCUUCACAUUCUAG >mARM708 (SEQ ID NO: 39) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCAUGCUUUUUAAUCUCCGCAUCCUC CUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACUUCA GAUGUGGCCAGCCGCUUCAAAACAAGGUCCAGCUGAAGGGCCGGGAUCUUCU GACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGGCUCUCC GCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGCUUC AAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCGCCU UUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUGACG ACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCCGGG UGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUCCGA UCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCCAUCAUCAACGGCCUGAGC GACCUGUACCACCCAAUCCAAAUCCUGGCUGACUACCUGACCCUGCAAGAGC ACUACAGCAGCCUGAAGGGUCUGACCCUGUCAUGGAUUGGCGAUGGAAACAA UAUUCUGCACUCCAUCAUGAUGUCCGCCGCGAAGUUCGGAAUGCAUCUGCAA GCCGCCACGCCAAAAGGAUACGAACCGGAUGCGUCCGUGACGAAGUUGGCGG AACAGUACGCGAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCCCCU CGAGGCUGCGCAUGGGGGCAACGUGCUGAUUACCGACACCUGGAUCUCCAUG GGGCAGGAGGAAGAGAAGAAGAAGAGACUGCAGGCAUUCCAGGGGUACCAG GUCACCAUGAAAACCGCAAAAGUGGCAGCUUCGGACUGGACUUUCCUGCAUU GCCUGCCGAGGAAGCCGGAGGAAGUCGACGACGAAGUGUUCUACUCGCCUCG GUCCCUGGUGUUCCCCGAGGCCGAAAACCGGAAGUGGACCAUCAUGGCCGUG AUGGUGUCCUUGCUGACUGACUAUAGCCCGCAGCUGCAGAAGCCUAAGUUCU AGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUCAAG AACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACAAAA UGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAAAGU UUCUUCACAUUCUAG >mARM709 (SEQ ID NO: 40) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCAUGCUUUUCAACCUGAGAAUCCUC UUGAACAAUGCUGCUUUUCGGAAUGGCCACAACUUUAUGGUUCGGAACUUCC GUUGCGGCCAGCCUUUACAAAACAAGGUCCAGCUGAAGGGCCGGGAUUUGCU CACACUGAAGAACUUUACUGGAGAAGAGAUCAAGUACAUGCUGUGGCUGUCG GCCGACCUGAAGUUCAGGAUCAAGCAGAAGGGAGAAUACCUUCCGCUGCUUC AAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCGCCU UUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUGACG ACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCCGGG UGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUCCGA UCUCGAUACCUUGGCAAAGGAGGCUUCCAUUCCCAUCAUCAACGGCCUGAGC GACCUGUACCACCCAAUCCAAAUCCUGGCUGACUACCUGACCCUGCAAGAGC ACUACAGCAGCCUGAAGGGUCUGACCCUGUCAUGGAUUGGCGAUGGAAACAA UAUUCUGCACUCCAUCAUGAUGUCCGCCGCGAAGUUCGGAAUGCAUCUGCAA GCCGCCACUCCAAAAGGAUACGAACCGGAUGCGUCCGUGACCAAGUUGGCGG AACAGUACGCGAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCCCCU CGAGGCUGCGCAUGGGGGCAACGUGCUGAUUACCGACACCUGGAUCUCCAUG GGGCAGGAGGAAGAGAAGAAGAAGAGACUGCAGGCAUUCCAGGGGUACCAG GUCACCAUGAAAACCGCAAAAGUGGCAGCUUCGGACUGGACUUUCCUGCAUU GCCUGCCGAGGAAGCCGGAGGAAGUCGACGACGAAGUGUUCUACUCGCCUCG GUCCCUGGUGUUCCCCGAGGCCGAAAACCGGAAGUGGACCAUCAUGGCCGUG AUGGUGUCCUUGCUGACUGACUAUAGCCCGCAGCUGCAGAAGCCUAAGUUCU AGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUCAAG AACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACAAAA UGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAAAGU UUCUUCACAUUCUAG >mARM710 (SEQ ID NO: 41) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCAUGCUUUUCAACCUGAGAAUCCUC UUGAACAAUGCUGCUUUUCGGAAUGGCCACAACUUUAUGGUUCGGAACUUCC GUUGCGGCCAGCCUUUACAAAACAAGGUCCAGCUGAAGGGCCGGGAUUUGCU CACACUAAAGAACUUUACUGGAGAAGAGAUCAAGUACAUGCUAUGGCUGUCG GCCGACCUGAAGUUCCGUAUCAAGCAGAAGGGAGAAUACCUUCCGCUGCUUC AAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCGCCU UUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUGACG ACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCCGGG UGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUCCGA UCUCGAUACCUUGGCAAAGGAGGCUUCCAUUCCCAUCAUCAACGGCCUGAGC GACCUGUACCACCCAAUCCAAAUCCUGGCUGACUACCUGACCCUGCAAGAGC ACUACAGCAGCCUGAAGGGUCUGACCCUGUCAUGGAUUGGCGAUGGAAACAA UAUUCUGCACUCCAUCAUGAUGUCCGCCGCGAAGUUCGGAAUGCAUCUGCAA GCCGCCACUCCAAAAGGAUACGAACCGGAUGCAUCCGUGACCAAGUUGGCGG AACAGUACGCGAAGGAGAACGGAACCAAGCUCCUGCUGACUAACGACCCGCU CGAGGCUGCGCAUGGGGGUAACGUGCUGAUUACGGACACCUGGAUCUCCAUG GGGCAGGAGGAAGAGAAGAAGAAGAGACUGCAGGCAUUCCAGGGGUACCAG GUCACCAUGAAAACCGCAAAAGUGGCAGCUUCGGACUGGACUUUCCUGCAUU GCCUGCCGAGGAAGCCGGAGGAAGUCGACGACGAAGUGUUCUACUCGCCUCG GUCCCUGGUGUUCCCCGAGGCCGAAAACCGGAAGUGGACCAUCAUGGCCGUG AUGGUGUCCUUGCUGACUGACUAUAGCCCGCAGCUGCAGAAGCCUAAGUUCU AGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUCAAG AACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACAAAA UGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAAAGU UUCUUCACAUUCUAG >mARM711 (SEQ ID NO: 42) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCAUGCUUUUCAACCUGAGAAUCCUC UUGAACAAUGCUGCUUUUCGGAAUGGCCACAACUUUAUGGUUCGGAACUUCC GUUGCGGCCAGCCUUUACAAAACAAGGUCCAGCUGAAGGGCCGGGAUUUGCU CACACUAAAGAACUUUACUGGAGAAGAGAUCAAGUACAUGCUAUGGCUGUCG GCCGACCUGAAGUUCCGUAUCAAGCAGAAGGGAGAAUACCUUCCGCUGCUUC AAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCGCCU UUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUGACG ACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCCGGG UGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUCCGA UCUCGAUACCUUGGCAAAGGAGGCUUCCAUUCCCAUCAUCAACGGCCUGAGC GACCUGUACCACCCAAUCCAAAUCCUGGCUGACUACCUGACCCUGCAAGAGC ACUACAGCAGCCUGAAGGGUCUGACCCUGUCAUGGAUUGGCGAUGGAAACAA UAUUCUGCACUCCAUCAUGAUGUCCGCCGCGAAGUUCGGAAUGCAUCUGCAA GCCGCCACUCCAAAAGGAUACGAACCGGAUGCGUCCGUGACCAAGUUGGCGG AACAGUACGCGAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCCCCU CGAGGCUGCGCAUGGGGGCAACGUGCUGAUUACCGACACCUGGAUCUCCAUG GGGCAGGAGGAAGAGAAGAAGAAGAGACUGCAGGCAUUCCAGGGGUACCAG GUCACCAUGAAAACCGCAAAAGUGGCAGCUUCGGACUGGACUUUCCUGCAUU GCCUGCCGAGGAAGCCGGAGGAAGUCGACGACGAAGUGUUCUACUCGCCUCG GUCCCUGGUGUUCCCCGAGGCCGAAAACCGGAAGUGGACCAUCAUGGCCGUG AUGGUGUCCUUGCUGACUGACUAUAGCCCGCAGCUGCAGAAGCCUAAGUUCU AGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUCAAG AACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACAAAA UGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAAAGU UUCUUCACAUUCUAG >mARM712 (SEQ ID NO: 43) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGUUCAACCUGCGAAUC CUGCUGAACAACGCCGCUUUUCGGAACGGGCACAACUUUAUGGUGAGGAACU UUCGCUGCGGACAGCCCCUCCAGAAUAAGGUCCAGCUGAAGGGCAGGGACCU GCUGACCCUGAAAAAUUUCACAGGGGAGGAAAUCAAGUAUAUGCUGUGGCU GUCAGCUGAUCUGAAGUUCCGGAUCAAGCAGAAGGGCGAAUAUCUGCCUCUG CUCCAGGGCAAAAGCCUGGGGAUGAUCUUCGAAAAGCGCAGUACUCGGACCA GACUGUCAACCGAGACUGGAUUCGCUCUGCUGGGAGGACACCCUUGUUUUCU GACCACUCAGGACAUUCACCUGGGAGUGAACGAGUCCCUGACCGACACUGCU CGCGUCCUGAGCUCUAUGGCCGACGCUGUGCUGGCUCGAGUCUACAAACAGU CCGACCUGGAUACCCUGGCCAAGGAAGCUUCUAUCCCAAUUAUUAACGGCCU GUCAGACCUGUAUCACCCCAUCCAGAUUCUGGCCGAUUACCUGACCCUCCAG GAGCACUAUUCUAGUCUGAAAGGGCUGACACUGAGUUGGAUUGGGGACGGA AACAAUAUCCUGCACUCUAUUAUGAUGUCAGCCGCCAAGUUUGGAAUGCACC UCCAGGCUGCAACCCCAAAAGGCUACGAACCCGAUGCCUCAGUGACAAAGCU GGCUGAACAGUACGCCAAAGAGAACGGCACUAAGCUGCUGCUGACCAACGAC CCUCUGGAGGCCGCUCACGGAGGCAACGUGCUGAUCACCGAUACCUGGAUUA GUAUGGGACAGGAGGAAGAGAAGAAGAAGCGGCUCCAGGCCUUCCAGGGCUA CCAGGUGACAAUGAAAACCGCUAAGGUCGCAGCCAGCGAUUGGACCUUUCUG CACUGCCUGCCCAGAAAGCCCGAAGAGGUGGACGACGAGGUCUUCUACUCUC CCAGAAGCCUGGUGUUUCCCGAAGCUGAGAAUAGGAAGUGGACAAUUAUGGC AGUGAUGGUCAGCCUGCUGACUGAUUAUUCACCUCAGCUCCAGAAACCAAAG UUCUGAUAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAG CCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACU UACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAA AGAAAGUUUCUUCACAUUCUAG >mARM713 (SEQ ID NO: 44) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGUUCAACCUGCGCAUC CUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCGCAACU UCCGCUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGGCCGCGACCU GCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUGCUGUGGCUG AGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCCCCUGC UGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGCACCCG CCUGAGCACCGAGACAGGCCUGGCCCUGCUGGGCGGCCACCCCUGCUUCCUG ACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACCGCCC GCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGCAGAG CGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGGCCUG AGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGCAGG AGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGCAA CAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCACCUG CAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCUGGC CGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGACCCC CUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCAGCA UGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUACCA GGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUGCAC UGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCCCCC GCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGCCGU GAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAGUUC UGAUAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCU CAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUAC AAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGA AAGUUUCUUCACAUUCUAG >mARM714 (SEQ ID NO: 45) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGUUCAACCUGCGAAUC CUGCUGAACAACGCCGCUUUUCGGAACGGGCACAACUUUAUGGUGAGGAACU UUCGCUGCGGACAGCCCCUCCAGAAUAAGGUCCAGCUGAAGGGCAGGGACCU GCUGACCCUGAAAAAUUUCACAGGGGAGGAAAUCAAGUAUAUGCUGUGGCU GUCAGCUGAUCUGAAGUUCCGGAUCAAGCAGAAGGGCGAAUAUCUGCCUCUG CUCCAGGGCAAAAGCCUGGGGAUGAUCUUCGAAAAGCGCAGUACUCGGACCA GACUGUCAACCGAGACUGGAUUCGCUCUGCUGGGAGGACACCCUUGUUUUCU GACCACUCAGGACAUUCACCUGGGAGUGAACGAGUCCCUGACCGACACUGCU CGCGUCCUGAGCUCUAUGGCCGACGCUGUGCUAGCUCGAGUCUACAAACAGU CCGACCUGGAUACCCUGGCCAAGGAAGCUUCUAUCCCAAUUAUUAACGGCCU GUCAGACCUGUAUCACCCCAUCCAGAUUCUGGCCGAUUACCUGACCCUCCAG GAGCACUAUUCUAGUCUGAAAGGGCUGACACUGAGUUGGAUUGGGGACGGA AACAAUAUCCUGCACUCUAUUAUGAUGUCAGCCGCCAAGUUUGGAAUGCACC UCCAGGCUGCAACCCCAAAAGGCUACGAACCCGAUGCCUCAGUGACAAAGCU GGCUGAACAGUACGCCAAAGAGAACGGCACUAAGCUGCUGCUGACCAACGAC CCUCUGGAGGCCGCUCACGGAGGCAACGUGCUGAUCACCGAUACCUGGAUUA GUAUGGGACAGGAGGAAGAGAAGAAGAAGCGGCUCCAGGCCUUCCAGGGCUA CCAGGUGACAAUGAAAACCGCUAAGGUCGCAGCCAGCGAUUGGACCUUUCUG CACUGCCUGCCCAGAAAGCCCGAAGAGGUGGACGACGAGGUCUUCUACUCUC CCAGAAGCCUGGUGUUUCCCGAAGCUGAGAAUAGGAAGUGGACAAUUAUGGC AGUGAUGGUCAGCCUGCUGACUGAUUAUUCACCUCAGCUCCAGAAACCAAAG UUCUGAUAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAG CCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACU UACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAA AGAAAGUUUCUUCACAUUCUAG >mARM715 (SEQ ID NO: 46) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGUUCAACCUGCGAAUC CUGCUGAACAAUGCCGCUUUUCGGAACGGGCACAAUUUCAUGGUGAGGAACU UUCGCUGCGGACAGCCCCUCCAGAACAAGGUCCAGCUGAAGGGCAGGGACCU GCUGACCCUGAAAAAUUUCACAGGGGAGGAAAUCAAGUACAUGCUGUGGCUG UCAGCCGAUCUGAAGUUCCGGAUCAAGCAGAAGGGCGAAUAUCUGCCUCUGC UCCAGGGCAAAAGCCUGGGGAUGAUCUUCGAAAAGCGCAGUACUCGGACCAG ACUGUCAACAGAGACUGGAUUCGCACUGCUGGGAGGACACCCAUGUUUUCUG ACCACACAGGACAUUCAUCUGGGAGUGAACGAGUCCCUGACCGACACAGCAC GCGUCCUGAGCUCCAUGGCUGAUGCAGUGCUGGCUCGAGUCUACAAACAGUC UGACCUGGAUACCCUGGCCAAGGAAGCUUCUAUCCCAAUCAUUAAUGGCCUG AGUGACCUGUAUCACCCCAUCCAGAUUCUGGCCGAUUACCUGACCCUCCAGG AGCAUUAUUCUAGUCUGAAAGGGCUGACACUGAGCUGGAUUGGGGACGGAA ACAAUAUCCUGCACUCCAUUAUGAUGAGCGCCGCCAAGUUUGGAAUGCACCU CCAGGCUGCAACCCCAAAAGGCUACGAACCCGAUGCCUCCGUGACAAAGCUG GCAGAACAGUAUGCCAAAGAGAACGGCACUAAGCUGCUGCUGACCAAUGACC CUCUGGAGGCCGCUCACGGAGGCAACGUGCUGAUCACUGAUACCUGGAUUAG UAUGGGACAGGAGGAAGAGAAGAAGAAGCGGCUCCAGGCCUUCCAGGGCUAC CAGGUGACAAUGAAAACUGCUAAGGUCGCAGCCAGCGACUGGACCUUUCUGC AUUGCCUGCCCAGAAAGCCUGAAGAGGUGGACGAUGAGGUCUUCUACUCACC CAGAAGCCUGGUGUUUCCUGAAGCUGAGAAUAGGAAGUGGACAAUCAUGGC AGUGAUGGUCAGCCUGCUGACUGAUUAUUCCCCUCAGCUCCAGAAACCAAAG UUCUGAUAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAG CCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACU UACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAA AGAAAGUUUCUUCACAUUCUAG >mARM716 (SEQ ID NO: 47) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAACCUUCGCAUU CUCCUCAACAACGCCGCGUUUAGAAACGGACACAACUUCAUGGUCCGCAACU UCCGCUGCGGACAGCCGCUGCAGAACAAGGUCCAGCUCAAGGGUCGGGAUCU CCUGACGCUGAAGAACUUUACCGGCGAAGAGAUUAAGUACAUGCUGUGGCUG UCCGCCGACCUUAAGUUCCGGAUCAAGCAGAAGGGCGAAUACCUUCCCCUGC UGCAAGGAAAGUCCCUGGGCAUGAUCUUCGAGAAGCGCAGUACCAGAACCAG ACUCUCCACUGAAACCGGGUUCGCGCUGCUUGGCGGCCACCCGUGUUUCCUC ACUACGCAAGACAUCCAUCUUGGCGUGAACGAGUCCCUUACCGACACCGCCA GGGUGCUGUCAAGCAUGGCCGACGCCGUCCUUGCGCGCGUGUACAAGCAGUC AGACCUUGAUACUCUGGCCAAGGAAGCCUCCAUCCCUAUUAUCAACGGCCUA UCCGACCUUUACCACCCGAUCCAGAUCCUCGCUGACUACCUGACCCUGCAAG AACACUACAGCAGCCUCAAGGGACUGACUCUGUCCUGGAUCGGCGACGGGAA CAACAUCCUGCACUCAAUCAUGAUGAGCGCAGCCAAGUUCGGCAUGCAUCUC CAAGCCGCUACACCCAAGGGUUAUGAACCGGACGCCUCUGUGACCAAGUUGG CAGAACAGUACGCCAAGGAGAACGGUACUAAGCUCCUUUUAACCAACGACCC CCUCGAAGCAGCCCAUGGCGGGAAUGUGCUCAUUACCGAUACCUGGAUUUCG AUGGGCCAGGAGGAGGAGAAGAAGAAGCGGCUGCAGGCGUUCCAGGGCUACC AGGUCACCAUGAAAACUGCCAAAGUGGCCGCCUCGGAUUGGACCUUUCUCCA CUGCCUGCCUCGGAAGCCUGAGGAGGUGGACGACGAAGUGUUCUACUCCCCA CGGUCCCUCGUGUUCCCCGAGGCCGAAAAUAGGAAGUGGACCAUCAUGGCCG UGAUGGUGUCCCUCUUGACCGAUUACAGCCCGCAGCUUCAGAAGCCUAAAUU CUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUCA AGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACAA AAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAAA GUUUCUUCACAUUCUAG >mARM717 (SEQ ID NO: 48) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAAUCUUCGCAUC CUGUUGAACAACGCCGCCUUCCGCAAUGGUCACAACUUCAUGGUCCGGAACU UCAGAUGUGGACAGCCUCUCCAAAACAAGGUCCAGCUGAAGGGAAGGGACCU CUUAACCCUCAAAAACUUUACUGGAGAGGAGAUCAAGUACAUGCUGUGGCUU AGCGCCGACCUUAAGUUCCGGAUCAAGCAGAAGGGAGAGUACCUCCCGCUGC UGCAAGGAAAGAGUCUUGGAAUGAUCUUCGAGAAGCGGUCCACCAGAACUCG CCUCUCCACUGAAACCGGAUUCGCACUCCUGGGUGGACACCCGUGCUUUCUG ACCACCCAAGACAUCCACCUCGGAGUGAACGAGAGCCUCACGGACACCGCGA GAGUGCUGUCAUCCAUGGCCGACGCCGUGCUUGCACGGGUCUACAAGCAGUC CGAUCUGGACACUCUUGCCAAGGAAGCCUCCAUUCCUAUCAUUAACGGUCUG UCGGAUCUGUACCACCCGAUUCAGAUCCUUGCGGACUACCUCACACUUCAAG AACACUAUUCAAGCCUAAAGGGUCUGACCCUGUCCUGGAUCGGAGAUGGAAA CAACAUUCUCCAUUCCAUCAUGAUGAGCGCUGCCAAGUUCGGAAUGCAUCUC CAAGCAGCGACUCCUAAGGGUUACGAGCCGGACGCCUCAGUGACUAAGCUGG CCGAGCAGUACGCCAAGGAGAACGGUACCAAACUGUUGCUUACUAACGACCC GCUUGAAGCGGCCCAUGGAGGAAACGUGCUGAUUACCGACACCUGGAUUUCG AUGGGACAGGAAGAGGAGAAGAAGAAGCGGCUCCAGGCGUUCCAGGGAUACC AGGUCACCAUGAAAACGGCCAAAGUGGCCGCUAGCGAUUGGACCUUUCUGCA CUGCCUCCCGCGCAAGCCUGAAGAAGUGGACGACGAAGUGUUCUACUCCCCU CGCUCUCUUGUGUUCCCGGAAGCCGAAAACAGGAAGUGGACCAUCAUGGCCG UGAUGGUGUCCCUCCUGACCGAUUACAGCCCGCAGCUGCAGAAGCCUAAGUU CUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUCA AGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACAA AAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAAA GUUUCUUCACAUUCUAG >mARM718 (SEQ ID NO: 49) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAAUCUCCGCAUC CUCCUCAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAGAACAAGGUCCAGCUCAAGGGCCGGGAUCU UCUGACCCUGAAGAACUUUACUGGCGAAGAAAUCAAGUACAUGCUCUGGCUC UCCGCCGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UGCAAGGAAAGUCGCUCGGCAUGAUCUUUGAGAAGCGCUCAACCCGCACCAG GCUGUCCACUGAAACCGGGUUCGCGCUGCUUGGUGGCCACCCCUGCUUCCUG ACCACCCAAGACAUUCACCUCGGAGUGAACGAAUCGCUCACUGAUACUGCCC GGGUGCUGUCGUCGAUGGCCGAUGCAGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCCAUCCCUAUUAUCAACGGCCUU UCCGACCUCUACCACCCGAUUCAGAUCCUUGCCGAUUACCUCACCCUGCAAG AACACUACUCGUCACUGAAGGGUCUGACCUUGUCCUGGAUCGGCGACGGCAA CAACAUCCUCCAUUCCAUUAUGAUGUCCGCCGCCAAAUUCGGCAUGCAUCUU CAAGCCGCAACCCCUAAGGGUUACGAGCCGGACGCUUCCGUGACCAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC CCUAGAGGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGACAGGAAGAAGAGAAGAAGAAGCGGUUACAGGCGUUCCAGGGCUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCGGACUGGACCUUCCUGC AUUGCCUGCCUCGCAAGCCCGAAGAAGUGGACGACGAGGUGUUCUACUCGCC ACGGUCCCUUGUGUUCCCUGAGGCCGAGAAUAGAAAGUGGACCAUUAUGGCC GUGAUGGUGUCCCUUCUCACCGACUACUCGCCGCAACUGCAGAAACCCAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM719 (SEQ ID NO: 50) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAAUCUUCGCAUC CUCCUCAACAACGCCGCCUUCCGGAACGGUCACAACUUCAUGGUCCGGAACU UCCGCUGCGGCCAGCCGCUCCAAAACAAAGUGCAGCUUAAGGGCCGCGAUCU CCUGACCCUGAAGAACUUCACCGGAGAGGAAAUCAAGUACAUGCUGUGGCUC UCGGCGGACCUGAAGUUUAGGAUUAAGCAGAAGGGGGAGUAUCUGCCGCUGC UCCAAGGGAAGUCCCUUGGCAUGAUCUUCGAAAAGAGGUCCACCCGGACUCG GCUCAGCACCGAAACAGGUUUUGCACUUCUGGGGGGCCACCCGUGCUUCCUG ACGACCCAGGACAUCCAUCUGGGUGUCAACGAGAGUUUGACCGACACUGCCA GAGUGCUGUCAUCCAUGGCGGACGCGGUGCUCGCGAGAGUGUACAAGCAGUC CGAUCUUGACACCCUGGCAAAAGAGGCUUCAAUCCCGAUCAUUAACGGACUC UCGGAUCUGUACCACCCUAUCCAAAUCUUGGCCGACUACCUGACCCUGCAAG AACACUACAGCUCCCUGAAGGGCCUGACUCUUUCCUGGAUUGGCGAUGGAAA CAACAUUCUCCAUUCUAUUAUGAUGUCCGCCGCCAAGUUCGGCAUGCACCUU CAAGCCGCCACCCCGAAGGGCUACGAACCUGACGCCUCCGUGACUAAGCUAG CCGAACAGUACGCUAAGGAGAACGGCACUAAGCUUCUCCUUACCAACGAUCC GCUGGAGGCGGCCCAUGGCGGAAAUGUGCUUAUCACCGACACCUGGAUUAGC AUGGGGCAGGAAGAAGAGAAGAAGAAACGGCUCCAGGCAUUCCAGGGCUACC AGGUCACCAUGAAAACUGCCAAGGUCGCCGCUAGCGACUGGACCUUCCUCCA CUGUCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCCCCG CGCUCCCUCGUGUUUCCUGAGGCCGAGAACAGAAAGUGGACCAUCAUGGCCG UGAUGGUGUCAUUACUUACGGACUACAGCCCGCAGCUGCAGAAGCCGAAGUU CUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUCA AGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACAA AAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAAA GUUUCUUCACAUUCUAG >mARM720 (SEQ ID NO: 51) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUUAACUUGAGAAUC CUUCUGAACAACGCCGCUUUCCGCAACGGUCAUAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCCCUCCAAAACAAAGUGCAGCUGAAGGGCCGGGACCU UCUUACGCUGAAGAAUUUCACCGGCGAAGAAAUCAAGUACAUGCUCUGGCUG UCCGCCGAUCUUAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUCCCGCUGC UGCAAGGGAAGUCGCUGGGCAUGAUUUUUGAGAAGCGGUCAACUCGCACCCG CCUGUCCACUGAAACUGGAUUCGCACUGCUCGGUGGCCAUCCCUGCUUCCUG ACCACCCAAGACAUCCACCUCGGCGUGAACGAGUCCCUGACUGACACCGCCCG GGUCUUAUCCUCGAUGGCCGAUGCUGUGCUUGCGAGGGUGUACAAGCAGUCC GACCUCGACACACUCGCGAAGGAGGCCUCCAUCCCCAUCAUCAACGGCCUGU CCGACCUUUACCACCCAAUUCAGAUCCUCGCCGAUUACCUGACCCUGCAAGA GCACUACUCGUCGCUCAAGGGGCUUACCCUCUCGUGGAUUGGCGACGGCAAC AACAUCCUUCACUCCAUCAUGAUGUCGGCAGCGAAGUUCGGCAUGCAUCUGC AAGCCGCCACGCCUAAGGGUUAUGAACCGGAUGCCUCAGUGACCAAGCUCGC CGAACAGUACGCGAAAGAGAAUGGAACCAAGCUACUUCUGACCAACGACCCC CUGGAGGCCGCUCACGGCGGCAACGUCCUCAUUACCGAUACUUGGAUUUCGA UGGGACAGGAAGAGGAAAAGAAGAAGAGACUGCAGGCGUUCCAGGGAUACC AGGUCACCAUGAAAACUGCCAAAGUGGCAGCCUCCGACUGGACCUUCCUUCA CUGCCUGCCGAGGAAGCCUGAAGAGGUGGACGACGAGGUGUUCUACUCCCCG CGCUCCUUGGUGUUUCCUGAGGCCGAAAACCGGAAGUGGACUAUCAUGGCCG UGAUGGUGUCCCUCCUCACCGACUACUCGCCGCAACUGCAGAAGCCUAAGUU CUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUCA AGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACAA AAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAAA GUUUCUUCACAUUCUAG >mARM721 (SEQ ID NO: 52) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGUUAUUCAACCUUAGAAUU CUCCUUAACAACGCCGCCUUCCGGAAUGGGCAUAACUUUAUGGUCCGCAAUU UCCGCUGUGGACAGCCUCUGCAAAACAAGGUCCAGCUCAAGGGCCGGGAUCU GCUGACUCUCAAGAACUUCACUGGGGAAGAAAUCAAGUACAUGCUCUGGCUG AGCGCCGACCUCAAGUUCCGCAUCAAGCAGAAGGGAGAGUACCUCCCGCUGC UCCAAGGGAAGUCCCUGGGCAUGAUCUUCGAGAAGAGAUCCACCCGCACCAG ACUUUCCACUGAGACUGGCUUCGCCUUGCUGGGAGGCCACCCAUGCUUCCUG ACGACCCAGGACAUUCACCUUGGCGUGAACGAGUCCCUGACUGACACCGCAA GGGUGUUGUCCUCGAUGGCCGACGCCGUGCUUGCCCGGGUGUACAAGCAGAG CGAUCUUGACACCCUGGCUAAGGAAGCUUCCAUUCCCAUCAUCAACGGUCUG AGCGACCUGUACCACCCGAUUCAGAUCCUGGCGGACUACCUAACCCUGCAAG AGCACUAUAGCUCCCUGAAGGGCCUCACACUUUCAUGGAUCGGCGACGGCAA CAACAUCCUGCACUCUAUUAUGAUGAGCGCUGCCAAAUUCGGCAUGCACCUC CAAGCCGCCACGCCUAAAGGCUACGAGCCCGACGCCUCGGUGACCAAGCUUG CGGAGCAGUACGCGAAGGAAAACGGCACCAAGCUGCUUCUCACCAACGAUCC UCUGGAAGCGGCCCAUGGUGGCAACGUGCUCAUUACCGACACUUGGAUCUCC AUGGGACAGGAGGAGGAAAAGAAGAAGCGGCUCCAGGCGUUUCAGGGUUAC CAGGUCACCAUGAAAACCGCCAAGGUCGCAGCCUCCGACUGGACCUUCCUUC AUUGCCUUCCGCGCAAGCCCGAAGAAGUGGACGAUGAAGUGUUUUACUCACC UCGGUCACUCGUGUUCCCGGAAGCAGAGAACAGGAAAUGGACCAUUAUGGCC GUGAUGGUGUCCCUGCUCACCGAUUACAGUCCGCAACUGCAGAAGCCCAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM722 (SEQ ID NO: 53) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAAAACAAGGUCCAGCUGAAGGGCCGGGAUCU UCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGGCUC UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCC GGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGCCUU AGUGACCUCUACCAUCCGAUUCAAAUCCUGGCCGAUUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGGCAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAUCUU CAAGCCGCCACGCCUAAGGGUUACGAACCCGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUGCUGCUGACUAACGACCC GCUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGCCAGGAGGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCUGC ACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC ACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUUCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM723 (SEQ ID NO: 54) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAAAACAAGGUCCAGCUUAAGGGCCGGGAUCU CCUCACCCUUAAAAACUUCACCGGCGAAGAGAUCAAGUACAUGCUCUGGCUC UCCGCGGACCUUAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCAG GCUUUCUACUGAAACUGGGUUCGCGCUUCUCGGCGGUCAUCCCUGCUUCCUC ACGACCCAAGACAUCCACCUCGGAGUGAACGAAUCCCUCACGGAUACUGCCC GCGUGCUUUCGAGCAUGGCAGACGCCGUGCUCGCCCGGGUGUACAAACAGUC CGAUCUCGACACUCUCGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGUCUU AGUGACCUUUACCACCCGAUCCAGAUCCUCGCCGAUUACCUCACACUCCAAG AACACUACAGCUCCCUUAAGGGUCUUACCCUCUCCUGGAUCGGCGACGGCAA CAACAUUCUCCACUCCAUCAUGAUGUCCGCCGCAAAGUUCGGCAUGCAUCUU CAAGCCGCCACCCCGAAGGGCUACGAGCCUGAUGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUUCUCACUAACGACCC ACUCGAAGCAGCCCAUGGGGGCAACGUGCUUAUCACUGACACCUGGAUCUCC AUGGGCCAGGAAGAAGAGAAGAAGAAGCGGCUCCAGGCGUUCCAGGGAUAUC AGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUUCUCCA CUGCCUCCCUCGCAAACCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCCC CGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUUAUGGCCG UGAUGGUGUCACUCCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGUU CUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUCA AGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACAA AAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAAA GUUUCUUCACAUUCUAG >mARM724 (SEQ ID NO: 55) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGACAUAACUUCAUGGUCCGGAACU UCAGAUGUGGACAGCCGCUUCAAAACAAGGUCCAGCUGAAGGGUCGGGAUCU UCUGACCCUGAAGAACUUUACCGGAGAAGAGAUCAAGUACAUGCUCUGGCUC UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGAGAAUACCUCCCGCUGC UUCAAGGAAAGAGCCUCGGAAUGAUUUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGAUUCGCGCUGCUGGGUGGACACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACUGAUACCGCCC GGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUCAUCAACGGACUU AGUGACCUCUACCAUCCGAUUCAAAUCCUGGCCGACUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGAGAUGGAAA CAACAUUCUCCACUCCAUCAUGAUGUCCGCCGCAAAAUUCGGAAUGCAUCUU CAAGCCGCCACGCCUAAGGGUUACGAACCCGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGUACCAAGCUUCUCCUGACCAACGACCC ACUAGAAGCAGCCCACGGUGGAAACGUGCUUAUUACUGACACUUGGAUCUCC AUGGGACAGGAGGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCUGC ACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC GCGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM725 (SEQ ID NO: 56) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAACCUCCGCAUU CUCCUCAACAACGCUGCCUUCCGGAAUGGACAUAACUUCAUGGUCCGGAACU UCAGAUGCGGACAGCCGCUUCAGAACAAGGUCCAGCUUAAGGGGAGAGAUCU CCUUACCCUCAAAAACUUCACUGGCGAAGAAAUCAAGUACAUGCUCUGGCUU AGUGCGGAUCUCAAGUUCCGCAUCAAGCAGAAGGGAGAAUACCUCCCGCUCC UUCAAGGAAAGAGCCUCGGCAUGAUUUUUGAGAAGAGGUCCACCAGAACUCG CCUUUCAACCGAGACUGGGUUCGCCCUGCUUGGCGGUCACCCCUGCUUCCUC ACUACCCAAGACAUCCACCUCGGCGUGAACGAGAGCCUUACCGACACCGCCC GCGUGCUCUCCUCAAUGGCCGACGCUGUGCUCGCCCGGGUGUACAAGCAGUC CGACCUUGAUACUCUCGCCAAGGAGGCCUCCAUCCCAAUUAUCAACGGGCUC UCUGAUCUCUACCACCCUAUCCAAAUCCUCGCGGACUACCUCACCCUCCAAGA GCACUAUAGCUCGCUCAAGGGCCUCACCCUUUCCUGGAUUGGCGACGGCAAC AACAUUCUUCACUCGAUCAUGAUGUCCGCCGCCAAGUUCGGCAUGCAUCUCC AAGCCGCGACCCCCAAGGGCUACGAGCCUGACGCAUCCGUGACCAAGCUCGC CGAGCAGUACGCGAAGGAAAAUGGCACCAAGCUUCUUCUCACCAACGACCCC CUUGAGGCCGCUCAUGGCGGCAACGUGCUCAUCACUGACACUUGGAUCAGCA UGGGCCAGGAGGAGGAAAAGAAGAAGCGCCUUCAGGCAUUCCAGGGUUACCA GGUCACCAUGAAAACCGCCAAAGUGGCCGCCUCCGACUGGACCUUUCUUCAC UGUCUCCCGCGGAAGCCUGAAGAAGUGGAUGACGAAGUGUUUUACUCCCCUC GGUCACUCGUGUUCCCGGAAGCAGAAAACAGGAAGUGGACCAUUAUGGCGGU CAUGGUGUCCCUCCUCACCGACUACAGCCCGCAGCUUCAGAAACCCAAGUUC UAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUCAA GAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACAAA AUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAAAG UUUCUUCACAUUCUAG >mARM726 (SEQ ID NO: 57) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAAUCUCCGCAUC CUCCUUAACAACGCAGCGUUUAGAAACGGUCACAACUUCAUGGUCCGGAACU UCCGCUGUGGACAGCCGCUUCAAAACAAGGUCCAGCUGAAGGGUCGGGACCU UCUGACCCUGAAGAACUUUACUGGAGAAGAGAUCAAGUACAUGCUUUGGCUG UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGAGAAUACCUUCCGCUGC UCCAAGGAAAGAGCCUGGGAAUGAUCUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGAUUCGCGCUGCUGGGUGGUCACCCUUGCUUCCUG ACGACCCAGGACAUUCACCUCGGAGUGAACGAGUCCCUCACUGAUACCGCCA GAGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCUAGGGUGUACAAACAGUC CGAUCUGGACACCCUGGCCAAGGAGGCAUCAAUUCCUAUUAUCAACGGACUU AGUGACCUCUACCAUCCGAUUCAAAUCCUGGCCGAUUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGAGAUGGAAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCGGCCAAGUUCGGAAUGCAUCUC CAAGCCGCCACGCCGAAAGGAUACGAGCCGGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC GCUAGAAGCCGCCCACGGUGGAAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGACAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCCGCCUCCGACUGGACCUUCCUUC ACUGCCUGCCUCGGAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC GCGGAGCCUCGUGUUCCCUGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUCCUCACCGACUACAGCCCGCAGCUUCAGAAGCCUAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM727 (SEQ ID NO: 58) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAAUCUCCGCAUU CUCCUCAACAACGCAGCCUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAGAACAAGGUCCAGCUCAAGGGCCGGGACCU CCUCACCCUCAAAAACUUUACCGGCGAAGAGAUCAAGUACAUGCUCUGGCUU UCGGCCGACCUUAAGUUCCGCAUCAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGUCCCUCGGCAUGAUCUUUGAAAAGCGCUCGACCAGGACCCG CCUUUCCACUGAAACCGGGUUCGCGCUUCUCGGUGGCCACCCCUGCUUCCUC ACCACCCAAGACAUUCACCUCGGAGUGAACGAAUCCCUUACCGAUACCGCAA GAGUGCUUUCGUCGAUGGCCGAUGCCGUGCUUGCGCGGGUGUACAAGCAGUC AGAUCUCGACACUCUCGCCAAGGAGGCGUCCAUUCCUAUUAUCAACGGCCUU UCCGACCUUUACCACCCGAUUCAGAUCCUCGCCGAUUACCUCACCCUGCAAG AGCACUACUCGUCACUCAAGGGUCUUACCCUCUCCUGGAUCGGCGACGGAAA CAACAUCCUCCAUUCGAUCAUGAUGUCCGCCGCCAAAUUCGGCAUGCACCUC CAAGCCGCGACCCCGAAGGGUUACGAGCCCGACGCUUCCGUGACCAAGCUCG CCGAACAGUACGCUAAGGAAAACGGCACCAAGCUCCUCCUCACUAACGACCC UCUCGAAGCAGCCCAUGGGGGCAACGUGCUCAUUACUGACACUUGGAUCUCG AUGGGCCAGGAAGAGGAGAAAAAGAAGCGGCUUCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCGGACUGGACCUUCCUUC ACUGCCUUCCGCGCAAGCCUGAAGAGGUGGACGAUGAGGUGUUCUACUCCCC ACGGUCCCUUGUGUUCCCCGAGGCCGAGAAUAGGAAGUGGACCAUCAUGGCC GUGAUGGUGUCGCUCCUCACUGACUACUCCCCGCAACUUCAGAAGCCUAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM728 (SEQ ID NO: 59) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGUUUAAUCUGAGAAUA CUUCUAAACAACGCCGCCUUCCGGAAUGGCCAUAACUUUAUGGUUCGGAAUU UCCGCUGCGGCCAGCCGCUGCAGAACAAGGUCCAGCUGAAGGGAAGAGACUU GCUGACCCUCAAGAACUUCACCGGAGAAGAAAUCAAGUAUAUGCUGUGGCUG UCCGCCGACCUGAAAUUCCGCAUCAAGCAGAAGGGCGAAUAUCUGCCGCUGU UGCAAGGGAAGUCCCUGGGGAUGAUCUUCGAGAAGAGGUCCACCAGAACACG GCUUUCAACCGAAACCGGGUUUGCACUGCUGGGUGGACACCCCUGUUUUCUG ACCACUCAAGAUAUCCACCUGGGCGUGAACGAGUCCCUUACCGACACUGCUA GGGUGUUGUCCAGCAUGGCCGAUGCCGUCCUGGCUCGCGUGUACAAGCAGUC CGACCUGGAUACCCUGGCAAAGGAAGCGUCCAUUCCCAUUAUCAACGGGCUG UCCGACCUGUACCAUCCGAUUCAAAUCCUGGCGGACUACCUGACUCUGCAAG AGCAUUACAGCAGCUUGAAGGGGCUUACUCUCUCGUGGAUCGGCGACGGGAA CAACAUCCUGCACUCCAUCAUGAUGUCCGCCGCCAAGUUCGGGAUGCAUUUG CAAGCUGCGACCCCGAAAGGUUACGAGCCCGAUGCUAGCGUAACUAAGCUUG CCGAACAGUACGCCAAAGAGAAUGGUACAAAACUGCUUCUGACUAACGACCC GCUGGAAGCAGCCCACGGCGGGAACGUGCUGAUAACCGACACCUGGAUUUCA AUGGGGCAGGAGGAAGAGAAGAAGAAGCGACUGCAGGCGUUCCAAGGCUAU CAGGUUACCAUGAAAACCGCCAAAGUGGCAGCCAGCGAUUGGACUUUCCUGC ACUGUCUGCCGCGGAAGCCCGAGGAAGUUGAUGACGAAGUAUUCUACUCACC CCGGAGCCUCGUGUUCCCCGAGGCCGAAAACCGGAAGUGGACUAUUAUGGCC GUGAUGGUGUCGCUGUUGACCGACUACAGCCCGCAACUGCAGAAGCCGAAGU UUUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM729 (SEQ ID NO: 60) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAACCUGAGGAUC CUUUUGAACAACGCCGCCUUUCGCAACGGCCACAACUUUAUGGUCCGCAAUU UCCGCUGCGGGCAGCCGCUGCAGAACAAGGUCCAGCUGAAGGGCCGGGAUCU GCUGACCCUGAAGAACUUCACCGGGGAGGAAAUCAAGUACAUGCUUUGGCUC UCCGCCGAUCUGAAGUUCAGAAUCAAGCAGAAGGGAGAGUACCUCCCGUUGC UGCAAGGAAAGUCACUCGGAAUGAUUUUCGAAAAGAGAAGCACUAGGACCCG CCUCUCAACUGAAACCGGGUUCGCGCUGCUCGGGGGCCAUCCGUGUUUCCUG ACUACCCAAGACAUCCACCUGGGAGUGAACGAGUCGCUGACCGACACCGCAC GCGUGCUGUCAUCCAUGGCGGACGCAGUGCUUGCCCGGGUGUACAAGCAGUC GGACCUGGACACUCUUGCCAAGGAGGCAUCAAUCCCCAUCAUUAACGGACUG UCCGAUCUCUACCACCCGAUUCAGAUCCUGGCUGACUACCUAACCCUGCAAG AGCACUACUCAAGCCUGAAGGGGCUGACCCUGUCGUGGAUCGGGGACGGCAA CAACAUUCUGCACUCCAUCAUGAUGUCGGCGGCUAAGUUCGGGAUGCAUUUG CAAGCGGCAACUCCGAAGGGUUAUGAACCCGACGCCUCCGUGACCAAGCUGG CCGAACAGUACGCCAAGGAAAACGGAACCAAGUUGCUGCUGACUAAUGAUCC CCUGGAGGCGGCCCACGGGGGGAACGUGCUGAUAACCGAUACCUGGAUCUCC AUGGGGCAGGAAGAAGAGAAGAAAAAGCGGCUGCAGGCAUUCCAGGGAUAC CAGGUCACCAUGAAAACCGCAAAAGUGGCAGCCAGCGACUGGACUUUCCUCC AUUGCCUGCCGCGAAAGCCGGAGGAGGUCGAUGACGAGGUGUUCUACUCCCC GCGGUCGCUGGUGUUCCCGGAGGCGGAAAACCGGAAGUGGACCAUUAUGGCC GUGAUGGUGUCACUCCUGACUGACUACAGCCCGCAACUGCAGAAGCCGAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM1787 (SEQ ID NO: 61) CUUAAGGGGGCGCUGCCUACGGAGGUGGCAGCCAUCUCCUUCUCGGCAUCAA GCUUACCAUGGUGCCCCAGGCCCUGCUCUUGGUCCCGCUGCUGGUGUUCCCC CUCUGCUUCGGCAAGUUCCCCAUCUACACCAUCCCCGACAAGCUGGGGCCGU GGAGCCCCAUCGACAUCCACCACCUGUCCUGCCCCAACAACCUCGUGGUCGAG GACGAGGGCUGCACCAACCUGAGCGGGUUCUCCUACAUGCUUUUCAAUCUCC GCAUCCUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCG GAACUUCAGAUGUGGCCAGCCGCUUCAAAACAAGGUCCAGCUGAAGGGCCGG GAUCUUCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCU GGCUCUCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCC GCUGCUUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGG ACCCGCCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCU UCCUGACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUAC CGCCCGGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAA CAGUCCGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACG GCCUUAGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCU GCAAGAACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGAC GGCAACAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGC AUCUUCAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAA GCUCGCCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAAC GACCCACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGA UCUCCAUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGG AUAUCAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUC CUGCACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACU CGCCACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAU GGCCGUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCC AAGUUCUAGAUAAGUGAAUGCAAGGCUGGCCGGAAGCCCUUGCCUGAAAGCA AGAUUUCAGCCUGGAAGAGGGCAAAGUGGACGGGAGUGGACAGGAGUGGAU GCGAUAAGAUGUGGUUUGAAGCUGAUGGGUGCCAGCCCUGCAUUGCUGAGUC AAUCAAUAAAGAGCUUUCUUUUGACCCAUUCUAGAUCUAG >mARM1788 (SEQ ID NO: 62) AGGAAACUUAAGAUUAUUACAUCAAAACAAAAAGCCGCCAAUGCUGUUCAAC CUGCGCAUCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGG UGCGCAACUUCCGCUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGG CCGCGACCUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUG CUGUGGCUGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACC UGCCCCUGCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCAC CCGCACCCGCCUGAGCACCGAGACAGGCCUGGCCCUGCUGGGCGGCCACCCCU GCUUCCUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGA CACCGCCCGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUAC AAGCAGAGCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCA ACGGCCUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACC CUGCAGGAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCG ACGGCAACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAU GCACCUGCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCA AGCUGGCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAA CGACCCCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGG AUCAGCAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGG GCUACCAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUU CCUGCACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUAC AGCCCCCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCA UGGCCGUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCC CAAGUUCUGAACGCCGAAGCCUGCAGCCAUGCGACCCCACGCCACCCCGUGCC UCCUGCCUCCGCGCAGCCUGCAGCGGGAGACCCUGUCCCCGCCCCAGCCGUCC UCCUGGGGUGGACCCUAGUUUAAUAAAGAUUCACCAAGUUUCACGCAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAA >mARM1789 (SEQ ID NO: 63) CUUAAGGGGGCGCUGCCUACGGAGGUGGCAGCCAUCUCCUUCUCGGCAUCAA GCUUACCAUGGUGCCCCAGGCCCUGCUCUUGGUCCCGCUGCUGGUGUUCCCC CUCUGCUUCGGCAAGUUCCCCAUCUACACCAUCCCCGACAAGCUGGGGCCGU GGAGCCCCAUCGACAUCCACCACCUGUCCUGCCCCAACAACCUCGUGGUCGAG GACGAGGGCUGCACCAACCUGAGCGGGUUCUCCUACAUGCUGUUCAACCUGC GCAUCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCG CAACUUCCGCUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGGCCGC GACCUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUGCUGU GGCUGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCC CCUGCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGC ACCCGCCUGAGCACCGAGACAGGCCUGGCCCUGCUGGGCGGCCACCCCUGCUU CCUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACC GCCCGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGC AGAGCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGG CCUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGC AGGAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGG CAACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCAC CUGCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCU GGCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGAC CCCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCA GCAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUA CCAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUG CACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCC CCCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGC CGUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAG UUCUGAAUAAGUGAUGCAAGGCUGGCCGGAAGCCCUUGCCUGAAAGCAAGAU UUCAGCCUGGAAGAGGGCAAAGUGGACGGGAGUGGACAGGAGUGGAUGCGA UAAGAUGUGGUUUGAAGCUGAUGGGUGCCAGCCCUGCAUUGCUGAGUCAAUC AAUAAAGAGCUUUCUUUUGACCCAUUCUAGAUCUAG >mARM1790 (SEQ ID NO: 64) AGGAAACUUAAGAUUAUUACAUCAAAACAAAAAGCCGCCAAUGCUUUUCAAU CUCCGCAUCCUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGG UCCGGAACUUCAGAUGUGGCCAGCCGCUUCAAAACAAGGUCCAGCUGAAGGG CCGGGAUCUUCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUG CUCUGGCUCUCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACC UUCCGCUGCUUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAAC CAGGACCCGCCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCC UGCUUCCUGACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCG AUACCGCCCGGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUA CAAACAGUCCGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUC AACGGCCUUAGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCA CCCUGCAAGAACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGG CGACGGCAACAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGC AUGCAUCUUCAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGA CUAAGCUCGCCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGAC UAACGACCCACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACC UGGAUCUCCAUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCC AGGGAUAUCAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGAC CUUCCUGCACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUC UACUCGCCACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCA UCAUGGCCGUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAA GCCCAAGUUCUAGACGCCGAAGCCUGCAGCCAUGCGACCCCACGCCACCCCGU GCCUCCUGCCUCCGCGCAGCCUGCAGCGGGAGACCCUGUCCCCGCCCCAGCCG UCCUCCUGGGGUGGACCCUAGUUUAAUAAAGAUUCACCAAGUUUCACGCAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAA >mARM1791 (SEQ ID NO: 65) CUUAAGGGGGCGCUGCCUACGGAGGUGGCAGCCAUCUCCUUCUCGGCAUCAA GCUUACCAUGGUGCCCCAGGCCCUGCUCUUGGUCCCGCUGCUGGUGUUCCCC CUCUGCUUCGGCAAGUUCCCCAUCUACACCAUCCCCGACAAGCUGGGGCCGU GGAGCCCCAUCGACAUCCACCACCUGUCCUGCCCCAACAACCUCGUGGUCGAG GACGAGGGCUGCACCAACCUGAGCGGGUUCUCCUACAUGCUUUUCAACCUGA GAAUCCUCUUGAACAAUGCUGCUUUUCGGAAUGGCCACAACUUUAUGGUUCG GAACUUCCGUUGCGGCCAGCCUUUACAAAACAAGGUCCAGCUGAAGGGCCGG GAUUUGCUCACACUAAAGAACUUUACUGGAGAAGAGAUCAAGUACAUGCUA UGGCUGUCGGCCGACCUGAAGUUCCGUAUCAAGCAGAAGGGAGAAUACCUUC CGCUGCUUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAG GACCCGCCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGC UUCCUGACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUA CCGCCCGGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAA ACAGUCCGAUCUCGAUACCUUGGCAAAGGAGGCUUCCAUUCCCAUCAUCAAC GGCCUGAGCGACCUGUACCACCCAAUCCAAAUCCUGGCUGACUACCUGACCC UGCAAGAGCACUACAGCAGCCUGAAGGGUCUGACCCUGUCAUGGAUUGGCGA UGGAAACAAUAUUCUGCACUCCAUCAUGAUGUCCGCCGCGAAGUUCGGAAUG CAUCUGCAAGCCGCCACUCCAAAAGGAUACGAACCGGAUGCAUCCGUGACCA AGUUGGCGGAACAGUACGCGAAGGAGAACGGAACCAAGCUCCUGCUGACUAA CGACCCGCUCGAGGCUGCGCAUGGGGGUAACGUGCUGAUUACGGACACCUGG AUCUCCAUGGGGCAGGAGGAAGAGAAGAAGAAGAGACUGCAGGCAUUCCAG GGGUACCAGGUCACCAUGAAAACCGCAAAAGUGGCAGCUUCGGACUGGACUU UCCUGCAUUGCCUGCCGAGGAAGCCGGAGGAAGUCGACGACGAAGUGUUCUA CUCGCCUCGGUCCCUGGUGUUCCCCGAGGCCGAAAACCGGAAGUGGACCAUC AUGGCCGUGAUGGUGUCCUUGCUGACUGACUAUAGCCCGCAGCUGCAGAAGC CUAAGUUCUAGAUAAGUGAUGCAAGGCUGGCCGGAAGCCCUUGCCUGAAAGC AAGAUUUCAGCCUGGAAGAGGGCAAAGUGGACGGGAGUGGACAGGAGUGGA UGCGAUAAGAUGUGGUUUGAAGCUGAUGGGUGCCAGCCCUGCAUUGCUGAG UCAAUCAAUAAAGAGCUUUCUUUUGACCCAUUCUAGAUCUAG >mARM1792 (SEQ ID NO: 66) UGAGUGUCGUACAGCCUCCAGGCCCCCCCCUCCCGGGAGAGCCAUAGUGGUC UGCGGAACCGGUGAGUACACCGGAAUUGCCGGGAAGACUGGGUCCUUUCUUG GAUAAACCCACUCUAUGCCCGGCCAUUUGGGCGUGCCCCCGCAAGACUGCUA GCCGAGUAGUGUUGGGUUGCGAUGCUGUUCAACCUGCGCAUCCUGCUGAACA ACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCGCAACUUCCGCUGCGG CCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGGCCGCGACCUGCUGACCCUG AAGAACUUCACCGGCGAGGAGAUCAAGUACAUGCUGUGGCUGAGCGCCGACC UGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCCCCUGCUGCAGGGCAA GAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGCACCCGCCUGAGCACC GAGACAGGCCUGGCCCUGCUGGGCGGCCACCCCUGCUUCCUGACCACCCAGG ACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACCGCCCGCGUGCUGAG CAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGCAGAGCGACCUGGAC ACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGGCCUGAGCGACCUGU ACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGCAGGAGCACUACAGC AGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGCAACAACAUCCUGC ACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCACCUGCAGGCCGCCAC CCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCUGGCCGAGCAGUAC GCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGACCCCCUGGAGGCCG CCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCAGCAUGGGCCAGGA GGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUACCAGGUGACCAUG AAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUGCACUGCCUGCCCC GCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCCCCCGCAGCCUGGU GUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGCCGUGAUGGUGAGC CUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAGUUCUGAAUAAGUG AUAGAGCGGCAAACCCUAGCUACACUCCAUAGCUAGUUUCUUUUUUUUUUGU UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUCCUUUCUUUUCCU UCUUUUUUUCCUCUUUUCUUGGUGGCUCCAUCUUAGCCCUAGUCACGGCUAG CUGUGAAAGGUCCGUGAGCCGCAUGACUGCAGAGAGUGCCGUAACUGGCCUC UCUGCAGAUCAUGUUCUAG >mARM1793 (SEQ ID NO: 67) AGGAAACUUAAGAUUAUUACAUCAAAACAAAAAGCCGCCAAUGCUUUUCAAU CUCCGCAUCCUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGG UCCGGAACUUCAGAUGUGGCCAGCCGCUUCAAAACAAGGUCCAGCUGAAGGG CCGGGAUCUUCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUG CUCUGGCUCUCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACC UUCCGCUGCUUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAAC CAGGACCCGCCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCC UGCUUCCUGACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCG AUACCGCCCGGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUA CAAACAGUCCGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUC AACGGCCUUAGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCA CCCUGCAAGAACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGG CGACGGCAACAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGC AUGCAUCUUCAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGA CUAAGCUCGCCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGAC UAACGACCCACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACC UGGAUCUCCAUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCC AGGGAUAUCAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGAC CUUCCUGCACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUC UACUCGCCACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCA UCAUGGCCGUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAA GCCCAAGUUCUAGGCUGGAGCCUCGGUAGCCGUUCCUCCUGCCCGCUGGGCC UCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUCCUGGUCUUUGAAUA AAGUCUGAGUGGGCAGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA >mARM1794 (SEQ ID NO: 68) AGGAAACUUAAGAUUAUUACAUCAAAACAAAAAGCCGCCAAUGCUGUUCAAC CUGCGCAUCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGG UGCGCAACUUCCGCUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGG CCGCGACCUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUG CUGUGGCUGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACC UGCCCCUGCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCAC CCGCACCCGCCUGAGCACCGAGACAGGCCUGGCCCUGCUGGGCGGCCACCCCU GCUUCCUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGA CACCGCCCGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUAC AAGCAGAGCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCA ACGGCCUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACC CUGCAGGAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCG ACGGCAACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAU GCACCUGCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCA AGCUGGCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAA CGACCCCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGG AUCAGCAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGG GCUACCAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUU CCUGCACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUAC AGCCCCCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCA UGGCCGUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCC CAAGUUCUGAGCUGGAGCCUCGGUAGCCGUUCCUCCUGCCCGCUGGGCCUCC CAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUCCUGGUCUUUGAAUAAA GUCUGAGUGGGCAGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA >mARM1795 (SEQ ID NO: 69) AGGAAACUUAAGAUUAUUACAUCAAAACAAAAAGCCGCCAAUGCUUUUCAAC CUGAGAAUCCUCUUGAACAAUGCUGCUUUUCGGAAUGGCCACAACUUUAUGG UUCGGAACUUCCGUUGCGGCCAGCCUUUACAAAACAAGGUCCAGCUGAAGGG CCGGGAUUUGCUCACACUAAAGAACUUUACUGGAGAAGAGAUCAAGUACAUG CUAUGGCUGUCGGCCGACCUGAAGUUCCGUAUCAAGCAGAAGGGAGAAUACC UUCCGCUGCUUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAAC CAGGACCCGCCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCC UGCUUCCUGACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCG AUACCGCCCGGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUA CAAACAGUCCGAUCUCGAUACCUUGGCAAAGGAGGCUUCCAUUCCCAUCAUC AACGGCCUGAGCGACCUGUACCACCCAAUCCAAAUCCUGGCUGACUACCUGA CCCUGCAAGAGCACUACAGCAGCCUGAAGGGUCUGACCCUGUCAUGGAUUGG CGAUGGAAACAAUAUUCUGCACUCCAUCAUGAUGUCCGCCGCGAAGUUCGGA AUGCAUCUGCAAGCCGCCACUCCAAAAGGAUACGAACCGGAUGCAUCCGUGA CCAAGUUGGCGGAACAGUACGCGAAGGAGAACGGAACCAAGCUCCUGCUGAC UAACGACCCGCUCGAGGCUGCGCAUGGGGGUAACGUGCUGAUUACGGACACC UGGAUCUCCAUGGGGCAGGAGGAAGAGAAGAAGAAGAGACUGCAGGCAUUC CAGGGGUACCAGGUCACCAUGAAAACCGCAAAAGUGGCAGCUUCGGACUGGA CUUUCCUGCAUUGCCUGCCGAGGAAGCCGGAGGAAGUCGACGACGAAGUGUU CUACUCGCCUCGGUCCCUGGUGUUCCCCGAGGCCGAAAACCGGAAGUGGACC AUCAUGGCCGUGAUGGUGUCCUUGCUGACUGACUAUAGCCCGCAGCUGCAGA AGCCUAAGUUCUAGGCUGGAGCCUCGGUAGCCGUUCCUCCUGCCCGCUGGGC CUCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUCCUGGUCUUUGAAU AAAGUCUGAGUGGGCAGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA >mARM1796 (SEQ ID NO: 70) AGGAAACUUAAGAAUUAUUGGUUAAAGAAGUAUAUUAGUGCUAAUUUCCCU CCGUUUGUCCUAGCUUUUCUCUUCUGUCAACCCCACACGCCUUUGGCACAAU GCUUUUCAAUCUCCGCAUCCUCCUUAACAACGCCGCGUUUAGAAACGGCCAC AACUUCAUGGUCCGGAACUUCAGAUGUGGCCAGCCGCUUCAAAACAAGGUCC AGCUGAAGGGCCGGGAUCUUCUGACCCUGAAGAACUUUACUGGCGAAGAGAU CAAGUACAUGCUCUGGCUCUCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAG GGGGAAUACCUUCCGCUGCUUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGA AGCGCUCAACCAGGACCCGCCUUUCUACUGAAACUGGGUUCGCGCUGCUCGG UGGCCACCCCUGCUUCCUGACGACCCAGGACAUCCACCUCGGAGUGAACGAA UCCCUCACCGAUACCGCCCGGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGG CCAGGGUGUACAAACAGUCCGAUCUGGACACUCUGGCCAAGGAGGCGUCAAU UCCUAUUAUCAACGGCCUUAGUGACCUCUACCAUCCGAUUCAGAUCCUGGCC GAUUACCUCACCCUGCAAGAACACUACAGCUCCCUGAAGGGUCUGACAUUGU CCUGGAUCGGCGACGGCAACAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGC AAAAUUCGGCAUGCAUCUUCAAGCCGCCACGCCGAAGGGUUACGAGCCCGAC GCUUCCGUGACUAAGCUCGCCGAGCAGUACGCUAAGGAGAACGGAACCAAGC UUCUGCUGACUAACGACCCACUAGAAGCAGCCCACGGGGGCAACGUGCUUAU UACUGACACCUGGAUCUCCAUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUG CAGGCGUUCCAGGGAUAUCAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCU CCGACUGGACCUUCCUGCACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGA CGAGGUGUUCUACUCGCCACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGA AAGUGGACCAUCAUGGCCGUGAUGGUGUCACUGCUCACCGACUACAGCCCGC AGCUUCAGAAGCCCAAGUUCUAGCUCGAGACACAUCACAACCACAACCUUCU CAGGCUACCCUGAGAAAAAAAGACAUGAAGACUCAGGACUCAUCUUUUCUGU UGGUGUAAAAUCAACACCCUAAGGAACACAAAUUUCUUUAAACAUUUGACUU CUUGUCUCUGUGCUGCAAUUAAUAAAAAAUGGAAAGAAUCUAUCUAG >mARM1797 (SEQ ID NO: 71) AGGAAACUUAAGAAUUAUUGGUUAAAGAAGUAUAUUAGUGCUAAUUUCCCU CCGUUUGUCCUAGCUUUUCUCUUCUGUCAACCCCACACGCCUUUGGCACAAU GCUGUUCAACCUGCGCAUCCUGCUGAACAACGCCGCCUUCCGCAACGGCCAC AACUUCAUGGUGCGCAACUUCCGCUGCGGCCAGCCCCUGCAGAACAAGGUGC AGCUGAAGGGCCGCGACCUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAU CAAGUACAUGCUGUGGCUGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAG GGCGAGUACCUGCCCCUGCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGA AGCGCAGCACCCGCACCCGCCUGAGCACCGAGACAGGCCUGGCCCUGCUGGGC GGCCACCCCUGCUUCCUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGA GCCUGACCGACACCGCCCGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGC CCGCGUGUACAAGCAGAGCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUC CCCAUCAUCAACGGCCUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGA CUACCUGACCCUGCAGGAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGC UGGAUCGGCGACGGCAACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCA AGUUCGGCAUGCACCUGCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCC AGCGUGACCAAGCUGGCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGC UGCUGACCAACGACCCCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCAC CGACACCUGGAUCAGCAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAG GCCUUCCAGGGCUACCAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCG ACUGGACCUUCCUGCACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGA GGUGUUCUACAGCCCCCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAG UGGACCAUCAUGGCCGUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGC UGCAGAAGCCCAAGUUCUGACUCGAGACACAUCACAACCACAACCUUCUCAG GCUACCCUGAGAAAAAAAGACAUGAAGACUCAGGACUCAUCUUUUCUGUUGG UGUAAAAUCAACACCCUAAGGAACACAAAUUUCUUUAAACAUUUGACUUCUU GUCUCUGUGCUGCAAUUAAUAAAAAAUGGAAAGAAUCUAUCUAG >mARM1798 (SEQ ID NO: 72) AGGAAACUUAAGAAUUAUUGGUUAAAGAAGUAUAUUAGUGCUAAUUUCCCU CCGUUUGUCCUAGCUUUUCUCUUCUGUCAACCCCACACGCCUUUGGCACAAU GCUUUUCAACCUGAGAAUCCUCUUGAACAAUGCUGCUUUUCGGAAUGGCCAC AACUUUAUGGUUCGGAACUUCCGUUGCGGCCAGCCUUUACAAAACAAGGUCC AGCUGAAGGGCCGGGAUUUGCUCACACUAAAGAACUUUACUGGAGAAGAGA UCAAGUACAUGCUAUGGCUGUCGGCCGACCUGAAGUUCCGUAUCAAGCAGAA GGGAGAAUACCUUCCGCUGCUUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAG AAGCGCUCAACCAGGACCCGCCUUUCUACUGAAACUGGGUUCGCGCUGCUCG GUGGCCACCCCUGCUUCCUGACGACCCAGGACAUCCACCUCGGAGUGAACGA AUCCCUCACCGAUACCGCCCGGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUG GCCAGGGUGUACAAACAGUCCGAUCUCGAUACCUUGGCAAAGGAGGCUUCCA UUCCCAUCAUCAACGGCCUGAGCGACCUGUACCACCCAAUCCAAAUCCUGGC UGACUACCUGACCCUGCAAGAGCACUACAGCAGCCUGAAGGGUCUGACCCUG UCAUGGAUUGGCGAUGGAAACAAUAUUCUGCACUCCAUCAUGAUGUCCGCCG CGAAGUUCGGAAUGCAUCUGCAAGCCGCCACUCCAAAAGGAUACGAACCGGA UGCAUCCGUGACCAAGUUGGCGGAACAGUACGCGAAGGAGAACGGAACCAAG CUCCUGCUGACUAACGACCCGCUCGAGGCUGCGCAUGGGGGUAACGUGCUGA UUACGGACACCUGGAUCUCCAUGGGGCAGGAGGAAGAGAAGAAGAAGAGAC UGCAGGCAUUCCAGGGGUACCAGGUCACCAUGAAAACCGCAAAAGUGGCAGC UUCGGACUGGACUUUCCUGCAUUGCCUGCCGAGGAAGCCGGAGGAAGUCGAC GACGAAGUGUUCUACUCGCCUCGGUCCCUGGUGUUCCCCGAGGCCGAAAACC GGAAGUGGACCAUCAUGGCCGUGAUGGUGUCCUUGCUGACUGACUAUAGCCC GCAGCUGCAGAAGCCUAAGUUCUAGCUCGAGACACAUCACAACCACAACCUU CUCAGGCUACCCUGAGAAAAAAAGACAUGAAGACUCAGGACUCAUCUUUUCU GUUGGUGUAAAAUCAACACCCUAAGGAACACAAAUUUCUUUAAACAUUUGAC UUCUUGUCUCUGUGCUGCAAUUAAUAAAAAAUGGAAAGAAUCUAUCUAG >mARM1799 (SEQ ID NO: 73) AUUAUUACAUCAAAACAAAAAGCCGCCACCAUGCUGUUCAACCUGCGCAUCC UGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCGCAACUU CCGCUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGGCCGCGACCUG CUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUGCUGUGGCUGA GCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCCCCUGCU GCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGCACCCGC CUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCUGCUUCCUGA CCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACCGCCCGC GUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGCAGAGCG ACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGGCCUGAG CGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGCAGGAGC ACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGCAACAA CAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCACCUGCAG GCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCUGGCCGA GCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGACCCCCUG GAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCAGCAUGG GCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUACCAGGU GACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUGCACUGC CUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCCCCCGCA GCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGCCGUGAU GGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAGUUCUGA GGUCUCUAGUAAUGAGCUGGAGCCUCGGUAGCCGUUCCUCCUGCCCGCUGGG CCUCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUCCUGGUCUUUGAA UAAAGUCUGAGUGGGCAUCUAG >mARM1800 (SEQ ID NO: 74) AGGAAACUUAAGAAUUAUUGGUUAAAGAAGUAUAUUAGUGCUAAUUUCCCU CCGUUUGUCCUAGCUUUUCUCUUCUGUCAACCCCACACGCCUUUGGCACAAU GCUGUUCAACCUGCGCAUCCUGCUGAACAACGCCGCCUUCCGCAACGGCCAC AACUUCAUGGUGCGCAACUUCCGCUGCGGCCAGCCCCUGCAGAACAAGGUGC AGCUGAAGGGCCGCGACCUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAU CAAGUACAUGCUGUGGCUGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAG GGCGAGUACCUGCCCCUGCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGA AGCGCAGCACCCGCACCCGCCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGC GGCCACCCCUGCUUCCUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGA GCCUGACCGACACCGCCCGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGC CCGCGUGUACAAGCAGAGCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUC CCCAUCAUCAACGGCCUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGA CUACCUGACCCUGCAGGAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGC UGGAUCGGCGACGGCAACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCA AGUUCGGCAUGCACCUGCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCC AGCGUGACCAAGCUGGCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGC UGCUGACCAACGACCCCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCAC CGACACCUGGAUCAGCAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAG GCCUUCCAGGGCUACCAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCG ACUGGACCUUCCUGCACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGA GGUGUUCUACAGCCCCCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAG UGGACCAUCAUGGCCGUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGC UGCAGAAGCCCAAGUUCUGACUCGAGACACAUCACAACCACAACCUUCUCAG GCUACCCUGAGAAAAAAAGACAUGAAGACUCAGGACUCAUCUUUUCUGUUGG UGUAAAAUCAACACCCUAAGGAACACAAAUUUCUUUAAACAUUUGACUUCUU GUCUCUGUGCUGCAAUUAAUAAAAAAUGGAAAGAAUCUAUCUAG >mARM1801 (SEQ ID NO: 75) AGGAAACUUAAGAUUAUUACAUCAAAACAAAAAGCCGCCAAUGCUGUUCAAC CUGCGCAUCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGG UGCGCAACUUCCGCUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGG CCGCGACCUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUG CUGUGGCUGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACC UGCCCCUGCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCAC CCGCACCCGCCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCU GCUUCCUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGA CACCGCCCGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUAC AAGCAGAGCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCA ACGGCCUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACC CUGCAGGAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCG ACGGCAACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAU GCACCUGCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCA AGCUGGCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAA CGACCCCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGG AUCAGCAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGG GCUACCAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUU CCUGCACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUAC AGCCCCCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCA UGGCCGUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCC CAAGUUCUGAACGCCGAAGCCUGCAGCCAUGCGACCCCACGCCACCCCGUGCC UCCUGCCUCCGCGCAGCCUGCAGCGGGAGACCCUGUCCCCGCCCCAGCCGUCC UCCUGGGGUGGACCCUAGUUUAAUAAAGAUUCACCAAGUUUCACGCAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAA >mARM1802 (SEQ ID NO: 76) CUUAAGGGGGCGCUGCCUACGGAGGUGGCAGCCAUCUCCUUCUCGGCAUCAA GCUUACCAUGGUGCCCCAGGCCCUGCUCUUGGUCCCGCUGCUGGUGUUCCCC CUCUGCUUCGGCAAGUUCCCCAUCUACACCAUCCCCGACAAGCUGGGGCCGU GGAGCCCCAUCGACAUCCACCACCUGUCCUGCCCCAACAACCUCGUGGUCGAG GACGAGGGCUGCACCAACCUGAGCGGGUUCUCCUACAUGCUGUUCAACCUGC GCAUCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCG CAACUUCCGCUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGGCCGC GACCUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUGCUGU GGCUGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCC CCUGCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGC ACCCGCCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCUGCUU CCUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACC GCCCGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGC AGAGCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGG CCUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGC AGGAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGG CAACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCAC CUGCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCU GGCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGAC CCCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCA GCAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUA CCAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUG CACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCC CCCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGC CGUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAG UUCUGAAUAAGUGAAUGCAAGGCUGGCCGGAAGCCCUUGCCUGAAAGCAAGA UUUCAGCCUGGAAGAGGGCAAAGUGGACGGGAGUGGACAGGAGUGGAUGCG AUAAGAUGUGGUUUGAAGCUGAUGGGUGCCAGCCCUGCAUUGCUGAGUCAA UCAAUAAAGAGCUUUCUUUUGACCCAUUCUAGAUCUAG >mARM1803 (SEQ ID NO: 77) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGGGCGUCUUCAACCUGCGG AUCCUGCUGAACAACGCCGCCUUCCGGAACGGCCACAACUUCAUGGUCCGCA ACUUCAGAUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGGCCGGGA CCUGCUGACCCUGAAGAACUUCACCGGCGAAGAGAUCAAGUACAUGCUGUGG CUGAGCGCCGACCUGAAGUUCCGGAUCAAGCAGAAGGGCGAGUACCUGCCCC UGCUGCAAGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGGAGCACCCGGAC CCGGCUGAGCACCGAGACAGGCUUUGCCCUGCUGGGAGGCCACCCCUGCUUU CUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACCG CCAGAGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGGGUGUACAAGCA GAGCGACCUGGACACCCUGGCCAAAGAGGCCAGCAUCCCCAUCAUCAACGGC CUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGCA GGAACACUACAGCUCCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGC AACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCAUC UGCAGGCCGCCACCCCCAAGGGCUACGAGCCUGAUGCCAGCGUGACCAAGCU GGCCGAGCAGUACGCCAAAGAGAACGGCACCAAGCUGCUGCUGACCAACGAC CCCCUGGAAGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCA GCAUGGGCCAGGAAGAGGAAAAGAAGAAGCGGCUGCAGGCCUUCCAGGGCUA CCAGGUCACAAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUG CACUGCCUGCCCCGGAAGCCCGAAGAGGUGGACGACGAGGUGUUCUACAGCC CCCGGUCCCUGGUGUUCCCCGAGGCCGAGAACCGGAAGUGGACCAUUAUGGC CGUGAUGGUGUCCCUGCUGACCGACUACUCCCCCCAGCUGCAGAAGCCCAAG UUCUAGAUAAGUGAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUA AACCAGCCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACU UACACUUACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUA AUAAAAAGAAAGUUUCUUCACAUUCUAG >mARM1804 (SEQ ID NO: 78) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGGGCGUCUUCAACCUGCGG AUCCUGCUGAACAACGCCGCCUUCCGGAACGGCCACAACUUCAUGGUCCGCA ACUUCAGAUGCGGCCAGCCCCUGCAGAACAGGGUGCAGCUGAAGGGCCGGGA CCUGCUGACCCUGAAGAACUUCACCGGCGAAGAGAUCAGGUACAUGCUGUGG CUGAGCGCCGACCUGAAGUUCCGGAUCAAGCAGAAGGGCGAGUACCUGCCCC UGCUGCAAGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGGAGCACCCGGAC CCGGCUGAGCACCGAGACAGGCUUUGCCCUGCUGGGAGGCCACCCCUGCUUU CUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACCG CCAGAGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGGGUGUACAAGCA GAGCGACCUGGACACCCUGGCCAAAGAGGCCAGCAUCCCCAUCAUCAACGGC CUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGCA GGAACACUACAGCUCCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGC AACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCAUC UGCAGGCCGCCACCCCCAAGGGCUACGAGCCUGAUGCCAGCGUGACCAAGCU GGCCGAGCAGUACGCCAAAGAGAACGGCACCAAGCUGCUGCUGACCAACGAC CCCCUGGAAGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCA GCAUGGGCCAGGAAGAGGAAAAGAAGAAGCGGCUGCAGGCCUUCCAGGGCUA CCAGGUCACAAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUG CACUGCCUGCCCCGGAAGCCCGAAGAGGUGGACGACGAGGUGUUCUACAGCC CCCGGUCCCUGGUGUUCCCCGAGGCCGAGAACCGGAAGUGGACCAUUAUGGC CGUGAUGGUGUCCCUGCUGACCGACUACUCCCCCCAGCUGCAGAAGCCCAAG UUCUAGAUAAGUGAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUA AACCAGCCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACU UACACUUACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUA AUAAAAAGAAAGUUUCUUCACAUUCUAG >mARM1805 (SEQ ID NO: 79) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGGUCUUCAACCUGCGG AUCCUGCUGAACAACGCCGCCUUCCGGAACGGCCACAACUUCAUGGUCCGCA ACUUCAGAUGCGGCCAGCCCCUGCAGAACAGGGUGCAGCUGAAGGGCCGGGA CCUGCUGACCCUGAAGAACUUCACCGGCGAAGAGAUCAGGUACAUGCUGUGG CUGAGCGCCGACCUGAAGUUCCGGAUCAAGCAGAAGGGCGAGUACCUGCCCC UGCUGCAAGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGGAGCACCCGGAC CCGGCUGAGCACCGAGACAGGCUUUGCCCUGCUGGGAGGCCACCCCUGCUUU CUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACCG CCAGAGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGGGUGUACAAGCA GAGCGACCUGGACACCCUGGCCAAAGAGGCCAGCAUCCCCAUCAUCAACGGC CUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGCA GGAACACUACAGCUCCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGC AACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCAUC UGCAGGCCGCCACCCCCAAGGGCUACGAGCCUGAUGCCAGCGUGACCAAGCU GGCCGAGCAGUACGCCAAAGAGAACGGCACCAAGCUGCUGCUGACCAACGAC CCCCUGGAAGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCA GCAUGGGCCAGGAAGAGGAAAAGAAGAAGCGGCUGCAGGCCUUCCAGGGCUA CCAGGUCACAAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUG CACUGCCUGCCCCGGAAGCCCGAAGAGGUGGACGACGAGGUGUUCUACAGCC CCCGGUCCCUGGUGUUCCCCGAGGCCGAGAACCGGAAGUGGACCAUUAUGGC CGUGAUGGUGUCCCUGCUGACCGACUACUCCCCCCAGCUGCAGAAGCCCAAG UUCUAGAUAAGUGAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUA AACCAGCCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACU UACACUUACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUA AUAAAAAGAAAGUUUCUUCACAUUCUAG >mARM1806 (SEQ ID NO: 80) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGUUCAACCUGAGGAUC CUGCUGAACAACGCAGCUUUCAGGAACGGCCACAACUUCAUGGUGAGGAACU UCCGGUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGGCAGGGACCU GCUGACCCUGAAGAACUUCACCGGAGAGGAGAUCAAGUACAUGCUGUGGCUG AGCGCAGACCUGAAGUUCAGGAUCAAGCAGAAGGGAGAGUACCUGCCCCUGC UGCAGGGGAAGUCCCUGGGCAUGAUCUUCGAGAAGAGGAGUACCAGGACCAG GCUGAGCACCGAAACCGGCUUCGCCCUGCUGGGAGGACACCCCUGCUUCCUG ACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGUCUGACCGACACCGCCA GGGUGCUGUCUAGCAUGGCCGACGCCGUGCUGGCCAGGGUGUACAAGCAGUC AGACCUGGACACCCUGGCUAAGGAGGCCAGCAUCCCCAUCAUCAACGGCCUG AGCGACCUGUACCACCCCAUCCAGAUCCUGGCUGACUACCUGACCCUGCAGG AGCACUACAGCUCUCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGGAA CAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCACCUG CAGGCCGCUACCCCCAAGGGUUACGAGCCCGACGCCAGCGUGACCAAGCUGG CAGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGACCC CCUGGAGGCCGCCCACGGAGGCAACGUGCUGAUCACCGACACCUGGAUCAGC AUGGGACAGGAGGAGGAGAAGAAGAAGCGGCUGCAGGCUUUCCAGGGUUAC CAGGUGACCAUGAAGACCGCCAAGGUGGCUGCCAGCGACUGGACCUUCCUGC ACUGCCUGCCCAGGAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACUCUCC CAGGAGCCUGGUGUUCCCCGAGGCCGAGAACAGGAAGUGGACCAUCAUGGCU GUGAUGGUGUCCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAGU UCUGAAUAAGUGAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAA ACCAGCCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUU ACACUUACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAA UAAAAAGAAAGUUUCUUCACAUUCUAG >mARM1808 (SEQ ID NO: 81) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGUUCAACCUGAGGAUC CUGCUGAACAACGCAGCUUUCAGGAACGGCCACAACUUCAUGGUGAGGAACU UCCGGUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGGCAGGGACCU GCUGACCCUGAAGAACUUCACCGGAGAGGAGAUCAAGUACAUGCUGUGGCUG AGCGCAGACCUGAAGUUCAGGAUCAAGCAGAAGGGAGAGUACCUGCCCCUGC UGCAGGGGAAGUCCCUGGGCAUGAUCUUCGAGAAGAGGAGUACCAGGACCAG GCUGAGCACCGAAACCGGCUUCGCCCUGCUGGGAGGACACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCC GGGUGUUAUCAAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCUAAGGAGGCCAGCAUCCCCAUCAUCAACGGCCUG AGCGACCUGUACCACCCCAUCCAGAUCCUGGCUGACUACCUGACCCUGCAGG AGCACUACAGCUCUCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGGAA CAACAUCCUGCACUCCAUCAUGAUGUCCGCCGCGAAGUUCGGAAUGCAUCUG CAAGCCGCCACGCCAAAAGGAUACGAACCGGAUGCGCCCGUGACAAAGUUGG CGGAACAGUACGCUAAGGAGAACGGAACCAAGCUGCUGCUGACCAACGACCC CCUGGAGGCCGCCCACGGAGGCAACGUGCUGAUCACCGACACCUGGAUCAGC AUGGGACAGGAGGAGGAGAAGAAGAAGCGGCUGCAGGCUUUCCAGGGUUAC CAGGUGACCAUGAAGACCGCCAAGGUGGCUGCCAGCGACUGGACCUUCCUGC ACUGCCUGCCCAGGAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACUCUCC CAGGAGCCUGGUGUUCCCCGAGGCCGAGAACAGGAAGUGGACCAUCAUGGCU GUGAUGGUGUCCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAGU UCUGAAUAAGUGAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAA ACCAGCCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUU ACACUUACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAA UAAAAAGAAAGUUUCUUCACAUUCUAG >mARM1809 (SEQ ID NO: 82) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGUUCAACCUGCGCAUC CUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCGCAACU UCCGCUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGGCCGCGACCU GCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUGCUGUGGCUG AGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCCCCUGC UGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGCACCCG CCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCUGCUUCCUG ACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACCGCCC GCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGCAGAG CGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGGCCUG AGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGCAGG AGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGCAA CAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCACCUG CAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCUGGC CGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGACCCC CUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCAGCA UGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUACCA GGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUGCAC UGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCCCCC GCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGCCGU GAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAGUUC UGAAUAAGUGAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAAC CAGCCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUAC ACUUACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUA AAAAGAAAGUUUCUUCACAUUCUAGAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAA >mARM1816 (SEQ ID NO: 83) AGGAAACUUAAGUCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUC AAGCAUUCUACUUCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAA GCAAUUUUCUGAAAAUUUUCACCAUUUACGAACGAUAGCCAUGCUGUUCAAC CUGCGCAUCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGG UGCGCAACUUCCGCUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGG CCGCGACCUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUG CUGUGGCUGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACC UGCCCCUGCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCAC CCGCACCCGCCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCU GCUUCCUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGA CACCGCCCGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUAC AAGCAGAGCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCA ACGGCCUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACC CUGCAGGAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCG ACGGCAACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAU GCACCUGCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCA AGCUGGCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAA CGACCCCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGG AUCAGCAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGG GCUACCAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUU CCUGCACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUAC AGCCCCCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCA UGGCCGUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCC CAAGUUCUGACUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUCA AGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACAA AAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAAA GUUUCUUCACAUUCUAG >mARM1822 (SEQ ID NO: 84) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAACUUGAGAAUC CUGCUGAACAACGCCGCCUUUCGCAACGGUCACAAUUUUAUGGUCAGAAACU UCAGAUGCGGACAGCCCCUCCAAAACAAGGUCCAGCUGAAGGGCCGCGAUCU CCUCACCCUGAAGAACUUCACGGGGGAGGAGAUCAAGUACAUGCUGUGGCUC UCCGCUGACCUGAAGUUCAGGAUCAAGCAGAAGGGAGAAUAUCUGCCGCUGC UGCAAGGGAAGUCCCUGGGGAUGAUUUUCGAGAAGCGGAGCACCCGGACUCG GCUCUCCACUGAAACUGGUUUCGCCCUUCUGGGCGGUCACCCCUGCUUCCUG ACCACUCAAGACAUUCACCUCGGAGUGAACGAGUCCUUGACUGACACCGCCC GGGUGCUGUCGAGCAUGGCAGACGCCGUGCUAGCCCGCGUGUACAAGCAGUC AGACCUCGAUACCCUGGCCAAGGAGGCUUCGAUCCCGAUCAUCAACGGGUUG UCCGACCUGUACCACCCGAUUCAGAUUCUCGCCGACUACCUCACCCUGCAAG AGCAUUACAGCUCCCUGAAGGGGCUUACCCUGUCCUGGAUUGGCGACGGAAA CAACAUCCUGCACUCCAUUAUGAUGUCGGCGGCCAAGUUCGGCAUGCACCUC CAAGCCGCGACCCCUAAGGGUUACGAACCAGACGCGUCAGUGACUAAGCUGG CCGAACAGUACGCAAAGGAAAAUGGCACGAAGCUGCUCCUGACCAACGAUCC GUUGGAAGCCGCCCAUGGCGGAAAUGUGCUCAUCACCGACACCUGGAUCUCG AUGGGACAGGAGGAAGAGAAGAAGAAGCGGCUGCAGGCGUUCCAGGGCUACC AGGUCACCAUGAAAACUGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUGCA CUGCCUUCCGCGCAAGCCUGAGGAGGUGGACGAUGAAGUGUUCUACUCUCCA CGGUCCCUGGUGUUCCCCGAGGCGGAGAACCGCAAAUGGACCAUCAUGGCUG UGAUGGUCAGCCUGCUGACCGAUUACAGCCCUCAGUUGCAAAAGCCGAAGUU UUGAUAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCC UCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUA CAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAG AAAGUUUCUUCACAUUCUAG >mARM1823 (SEQ ID NO: 85) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGUUCAACCUCCGCAUC CUCCUCAACAACGCCGCAUUCAGAAACGGGCACAACUUCAUGGUCAGAAACU UCCGCUGCGGGCAACCCCUACAAAACAAGGUCCAGCUCAAGGGGCGGGACCU CCUGACCCUGAAGAACUUCACCGGCGAAGAGAUCAAGUACAUGCUGUGGCUC UCCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGAGAGUACCUCCCGCUGC UGCAAGGGAAGUCGCUGGGGAUGAUCUUCGAGAAGCGGUCAACCAGAACCCG GCUGUCAACCGAAACCGGGUUCGCACUGCUGGGGGGACACCCGUGCUUCCUG ACCACCCAAGACAUCCACCUGGGAGUGAACGAAUCGCUGACCGACACCGCCC GCGUGCUGAGCUCAAUGGCGGACGCCGUGCUGGCCCGCGUGUACAAGCAGUC CGACCUGGACACCCUGGCCAAGGAAGCGUCCAUCCCGAUCAUCAACGGACUG UCCGACCUGUACCACCCGAUCCAGAUCCUGGCAGACUACCUGACCCUGCAAG AACACUACAGCUCCCUGAAGGGCCUGACCCUGUCAUGGAUCGGGGACGGGAA CAACAUCCUGCACUCCAUAAUGAUGUCAGCCGCCAAGUUCGGAAUGCACCUC CAAGCCGCAACCCCGAAGGGCUACGAACCGGACGCAUCAGUGACCAAACUGG CCGAGCAGUACGCCAAGGAAAACGGCACCAAGCUCCUGCUGACCAACGACCC GCUGGAGGCCGCACACGGGGGGAACGUGCUGAUCACCGACACCUGGAUCUCC AUGGGACAGGAGGAGGAAAAGAAGAAGCGGCUGCAGGCGUUCCAGGGGUAC CAGGUCACCAUGAAAACCGCGAAGGUCGCGGCAUCAGACUGGACCUUCCUGC ACUGCCUGCCCCGGAAGCCGGAAGAGGUGGACGACGAGGUGUUCUACUCGCC GCGCUCGCUGGUGUUCCCCGAGGCGGAGAACAGGAAGUGGACCAUCAUGGCG GUGAUGGUCAGCCUCCUGACCGACUACUCGCCGCAGCUGCAGAAGCCGAAGU UCUGAUAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGC CUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUU ACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAA GAAAGUUUCUUCACAUUCUAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAA >mARM1840 (SEQ ID NO: 86) CUCCCUCCCCCCCCCCUAACGUUACUGGCCGAAGCCGCUUGGAAUAAGGCCGG UGUGCGUUUGUCUAUAUGUUAUUUUCCACCAUAUUGCCGUCUUUUGGCAAUG UGAGGGCCCGGAAACCUGGCCCUGUCUUCUUGACGAGCAUUCCUAGGGGUCU UUCCCCUCUCGCCAAAGGAAUGCAAGGUCUGUUGAAUGUCGUGAAGGAAGCA GUUCCUCUGGAAGCUUCUUGAAGACAAACAACGUCUGUAGCGACCCUUUGCA GGCAGCGGAACCCCCCACCUGGCGACAGGUGCCUCUGCGGCCAAAAGCCACG UGUAUAAGAUACACCUGCAAAGGCGGCACAACCCCAGUGCCACGUUGUGAGU UGGAUAGUUGUGGAAAGAGUCAAAUGGCUCUCCUCAAGCGUAUUCAACAAG GGGCUGAAGGAUGCCCAGAAGGUACCCCAUUGUAUGGGAUCUGAUCUGGGGC CUCGGUGCACAUGCUUUACGUGUGUUUAGUCGAGGUUAAAAAACGUCUAGGC CCCCCGAACCACGGGGACGUGGUUUUCCUUUGAAAAACACGAUGAUAAUAUG CUUUUCAAUCUCCGCAUCCUCCUUAACAACGCCGCGUUUAGAAACGGCCACA ACUUCAUGGUCCGGAACUUCAGAUGUGGCCAGCCGCUUCAAAACAAGGUCCA GCUGAAGGGCCGGGAUCUUCUGACCCUGAAGAACUUUACUGGCGAAGAGAUC AAGUACAUGCUCUGGCUCUCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGG GGGAAUACCUUCCGCUGCUUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAA GCGCUCAACCAGGACCCGCCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGU GGCCACCCCUGCUUCCUGACGACCCAGGACAUCCACCUCGGAGUGAACGAAU CCCUCACCGAUACCGCCCGGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGC CAGGGUGUACAAACAGUCCGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUU CCUAUUAUCAACGGCCUUAGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCG AUUACCUCACCCUGCAAGAACACUACAGCUCCCUGAAGGGUCUGACAUUGUC CUGGAUCGGCGACGGCAACAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCA AAAUUCGGCAUGCAUCUUCAAGCCGCCACGCCGAAGGGUUACGAGCCCGACG CUUCCGUGACUAAGCUCGCCGAGCAGUACGCUAAGGAGAACGGAACCAAGCU UCUGCUGACUAACGACCCACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUU ACUGACACCUGGAUCUCCAUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGC AGGCGUUCCAGGGAUAUCAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUC CGACUGGACCUUCCUGCACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGAC GAGGUGUUCUACUCGCCACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAA AGUGGACCAUCAUGGCCGUGAUGGUGUCACUGCUCACCGACUACAGCCCGCA GCUUCAGAAGCCCAAGUUCUGAAUAAGUAGAUAGUGCAGUCACUGGCACAAC GCGUUGCCCGGUAAGCCAAUCGGGUAUACACGGUCGUCAUACUGCAGACAGG GUUCUUCUACUUUGCAAGAUAGUCUAGAGUAGUAAAAUAAAUAGUAUAAGU CUAG >mARM1841 (SEQ ID NO: 87) CUCCCUCCCCCCCCCCUAACGUUACUGGCCGAAGCCGCUUGGAAUAAGGCCGG UGUGCGUUUGUCUAUAUGUUAUUUUCCACCAUAUUGCCGUCUUUUGGCAAUG UGAGGGCCCGGAAACCUGGCCCUGUCUUCUUGACGAGCAUUCCUAGGGGUCU UUCCCCUCUCGCCAAAGGAAUGCAAGGUCUGUUGAAUGUCGUGAAGGAAGCA GUUCCUCUGGAAGCUUCUUGAAGACAAACAACGUCUGUAGCGACCCUUUGCA GGCAGCGGAACCCCCCACCUGGCGACAGGUGCCUCUGCGGCCAAAAGCCACG UGUAUAAGAUACACCUGCAAAGGCGGCACAACCCCAGUGCCACGUUGUGAGU UGGAUAGUUGUGGAAAGAGUCAAAUGGCUCUCCUCAAGCGUAUUCAACAAG GGGCUGAAGGAUGCCCAGAAGGUACCCCAUUGUAUGGGAUCUGAUCUGGGGC CUCGGUGCACAUGCUUUACGUGUGUUUAGUCGAGGUUAAAAAACGUCUAGGC CCCCCGAACCACGGGGACGUGGUUUUCCUUUGAAAAACACGAUGAUAAUAUG CUUUUCAACCUGAGAAUCCUCUUGAACAAUGCUGCUUUUCGGAAUGGCCACA ACUUUAUGGUUCGGAACUUCCGUUGCGGCCAGCCUUUACAAAACAAGGUCCA GCUGAAGGGCCGGGAUUUGCUCACACUAAAGAACUUUACUGGAGAAGAGAUC AAGUACAUGCUAUGGCUGUCGGCCGACCUGAAGUUCCGUAUCAAGCAGAAGG GAGAAUACCUUCCGCUGCUUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAA GCGCUCAACCAGGACCCGCCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGU GGCCACCCCUGCUUCCUGACGACCCAGGACAUCCACCUCGGAGUGAACGAAU CCCUCACCGAUACCGCCCGGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGC CAGGGUGUACAAACAGUCCGAUCUCGAUACCUUGGCAAAGGAGGCUUCCAUU CCCAUCAUCAACGGCCUGAGCGACCUGUACCACCCAAUCCAAAUCCUGGCUG ACUACCUGACCCUGCAAGAGCACUACAGCAGCCUGAAGGGUCUGACCCUGUC AUGGAUUGGCGAUGGAAACAAUAUUCUGCACUCCAUCAUGAUGUCCGCCGCG AAGUUCGGAAUGCAUCUGCAAGCCGCCACUCCAAAAGGAUACGAACCGGAUG CAUCCGUGACCAAGUUGGCGGAACAGUACGCGAAGGAGAACGGAACCAAGCU CCUGCUGACUAACGACCCGCUCGAGGCUGCGCAUGGGGGUAACGUGCUGAUU ACGGACACCUGGAUCUCCAUGGGGCAGGAGGAAGAGAAGAAGAAGAGACUGC AGGCAUUCCAGGGGUACCAGGUCACCAUGAAAACCGCAAAAGUGGCAGCUUC GGACUGGACUUUCCUGCAUUGCCUGCCGAGGAAGCCGGAGGAAGUCGACGAC GAAGUGUUCUACUCGCCUCGGUCCCUGGUGUUCCCCGAGGCCGAAAACCGGA AGUGGACCAUCAUGGCCGUGAUGGUGUCCUUGCUGACUGACUAUAGCCCGCA GCUGCAGAAGCCUAAGUUCUGAAUAAGUAGAUAGUGCAGUCACUGGCACAAC GCGUUGCCCGGUAAGCCAAUCGGGUAUACACGGUCGUCAUACUGCAGACAGG GUUCUUCUACUUUGCAAGAUAGUCUAGAGUAGUAAAAUAAAUAGUAUAAGU CUAG >mARM1842 (SEQ ID NO: 88) CUCCCUCCCCCCCCCCUAACGUUACUGGCCGAAGCCGCUUGGAAUAAGGCCGG UGUGCGUUUGUCUAUAUGUUAUUUUCCACCAUAUUGCCGUCUUUUGGCAAUG UGAGGGCCCGGAAACCUGGCCCUGUCUUCUUGACGAGCAUUCCUAGGGGUCU UUCCCCUCUCGCCAAAGGAAUGCAAGGUCUGUUGAAUGUCGUGAAGGAAGCA GUUCCUCUGGAAGCUUCUUGAAGACAAACAACGUCUGUAGCGACCCUUUGCA GGCAGCGGAACCCCCCACCUGGCGACAGGUGCCUCUGCGGCCAAAAGCCACG UGUAUAAGAUACACCUGCAAAGGCGGCACAACCCCAGUGCCACGUUGUGAGU UGGAUAGUUGUGGAAAGAGUCAAAUGGCUCUCCUCAAGCGUAUUCAACAAG GGGCUGAAGGAUGCCCAGAAGGUACCCCAUUGUAUGGGAUCUGAUCUGGGGC CUCGGUGCACAUGCUUUACGUGUGUUUAGUCGAGGUUAAAAAACGUCUAGGC CCCCCGAACCACGGGGACGUGGUUUUCCUUUGAAAAACACGAUGAUAAUAUG CUGUUCAACCUGCGCAUCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACA ACUUCAUGGUGCGCAACUUCCGCUGCGGCCAGCCCCUGCAGAACAAGGUGCA GCUGAAGGGCCGCGACCUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUC AAGUACAUGCUGUGGCUGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGG GCGAGUACCUGCCCCUGCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAA GCGCAGCACCCGCACCCGCCUGAGCACCGAGACAGGCCUGGCCCUGCUGGGCG GCCACCCCUGCUUCCUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAG CCUGACCGACACCGCCCGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCC GCGUGUACAAGCAGAGCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCC CAUCAUCAACGGCCUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGAC UACCUGACCCUGCAGGAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCU GGAUCGGCGACGGCAACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAA GUUCGGCAUGCACCUGCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCA GCGUGACCAAGCUGGCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCU GCUGACCAACGACCCCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACC GACACCUGGAUCAGCAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGG CCUUCCAGGGCUACCAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGA CUGGACCUUCCUGCACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAG GUGUUCUACAGCCCCCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGU GGACCAUCAUGGCCGUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCU GCAGAAGCCCAAGUUCUGAAUAAGUAGAUAGUGCAGUCACUGGCACAACGCG UUGCCCGGUAAGCCAAUCGGGUAUACACGGUCGUCAUACUGCAGACAGGGUU CUUCUACUUUGCAAGAUAGUCUAGAGUAGUAAAAUAAAUAGUAUAAGUCUA G >mARM1843 (SEQ ID NO: 89) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAAAACAAGGUCCAGCUGAAGGGCCGGGAUCU UCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGGCUC UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCC GGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGCCUU AGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGGCAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAUCUU CAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC ACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCUGC ACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC ACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM1844 (SEQ ID NO: 90) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAAAACAAGGUCCAGCUGAAGGGCCGGGAUCU UCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGGCUC UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCC GGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGCCUU AGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGGCAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAUCUU CAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC ACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCUGC ACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC ACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM1845 (SEQ ID NO: 91) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAAAACAAGGUCCAGCUGAAGGGCCGGGAUCU UCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGGCUC UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCC GGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGCCUU AGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGGCAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAUCUU CAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC ACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCUGC ACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC ACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM1846 (SEQ ID NO: 92) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAAAACAAGGUCCAGCUGAAGGGCCGGGAUCU UCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGGCUC UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCC GGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGCCUU AGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGGCAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAUCUU CAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC ACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCUGC ACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC ACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM1847 (SEQ ID NO: 93) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUUUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAAAACAAGGUCCAGCUGAAGGGCCGGGAUCU UCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGGCUC UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCC GGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGCCUU AGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGGCAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAUCUU CAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC ACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCUGC ACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC ACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM1882 (SEQ ID NO: 94) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGGUGUUCAACCUCCGCAUC CUCCUCAACAACGCCGCAUUCAGAAACGGGCACAACUUCAUGGUCAGAAACU UCCGCUGCGGGCAACCCCUACAAAACAAGGUCCAGCUCAAGGGGCGGGACCU CCUGACCCUGAAGAACUUCACCGGCGAAGAGAUCAAGUACAUGCUGUGGCUC UCCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGAGAGUACCUCCCGCUGC UGCAAGGGAAGUCGCUGGGGAUGAUCUUCGAGAAGCGGUCAACCAGAACCCG GCUGUCAACCGAAACCGGGUUCGCACUGCUGGGGGGACACCCGUGCUUCCUG ACCACCCAAGACAUCCACCUGGGAGUGAACGAAUCGCUGACCGACACCGCCC GCGUGCUGAGCUCAAUGGCGGACGCCGUGCUGGCCCGCGUGUACAAGCAGUC CGACCUGGACACCCUGGCCAAGGAAGCGUCCAUCCCGAUCAUCAACGGACUG UCCGACCUGUACCACCCGAUCCAGAUCCUGGCAGACUACCUGACCCUGCAAG AACACUACAGCUCCCUGAAGGGCCUGACCCUGUCAUGGAUCGGGGACGGGAA CAACAUCCUGCACUCCAUAAUGAUGUCAGCCGCCAAGUUCGGAAUGCACCUC CAAGCCGCAACCCCGAAGGGCUACGAACCGGACGCAUCAGUGACCAAACUGG CCGAGCAGUACGCCAAGGAAAACGGCACCAAGCUCCUGCUGACCAACGACCC GCUGGAGGCCGCACACGGGGGGAACGUGCUGAUCACCGACACCUGGAUCUCC AUGGGACAGGAGGAGGAAAAGAAGAAGCGGCUGCAGGCGUUCCAGGGGUAC CAGGUCACCAUGAAAACCGCGAAGGUCGCGGCAUCAGACUGGACCUUCCUGC ACUGCCUGCCCCGGAAGCCGGAAGAGGUGGACGACGAGGUGUUCUACUCGCC GCGCUCGCUGGUGUUCCCCGAGGCGGAGAACAGGAAGUGGACCAUCAUGGCG GUGAUGGUCAGCCUCCUGACCGACUACUCGCCGCAGCUGCAGAAGCCGAAGU UCUGAUAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGC CUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUU ACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAA GAAAGUUUCUUCACAUUCUAG >mARM1883 (SEQ ID NO: 95) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGGUGUUCAACCUCCGCAUC CUCCUCAACAACGCCGCAUUCAGAAACGGGCACAACUUCAUGGUCAGAAACU UCCGCUGCGGGCAACCCCUACAAAACCGGGUCCAGCUCAAGGGGCGGGACCU CCUGACCCUGAAGAACUUCACCGGCGAAGAGAUCAAGUACAUGCUGUGGCUC UCCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGAGAGUACCUCCCGCUGC UGCAAGGGAAGUCGCUGGGGAUGAUCUUCGAGAAGCGGUCAACCAGAACCCG GCUGUCAACCGAAACCGGGUUCGCACUGCUGGGGGGACACCCGUGCUUCCUG ACCACCCAAGACAUCCACCUGGGAGUGAACGAAUCGCUGACCGACACCGCCC GCGUGCUGAGCUCAAUGGCGGACGCCGUGCUGGCCCGCGUGUACAAGCAGUC CGACCUGGACACCCUGGCCAAGGAAGCGUCCAUCCCGAUCAUCAACGGACUG UCCGACCUGUACCACCCGAUCCAGAUCCUGGCAGACUACCUGACCCUGCAAG AACACUACAGCUCCCUGAAGGGCCUGACCCUGUCAUGGAUCGGGGACGGGAA CAACAUCCUGCACUCCAUAAUGAUGUCAGCCGCCAAGUUCGGAAUGCACCUC CAAGCCGCAACCCCGAAGGGCUACGAACCGGACGCAUCAGUGACCAAACUGG CCGAGCAGUACGCCAAGGAAAACGGCACCAAGCUCCUGCUGACCAACGACCC GCUGGAGGCCGCACACGGGGGGAACGUGCUGAUCACCGACACCUGGAUCUCC AUGGGACAGGAGGAGGAAAAGAAGAAGCGGCUGCAGGCGUUCCAGGGGUAC CAGGUCACCAUGAAAACCGCGAAGGUCGCGGCAUCAGACUGGACCUUCCUGC ACUGCCUGCCCCGGAAGCCGGAAGAGGUGGACGACGAGGUGUUCUACUCGCC GCGCUCGCUGGUGUUCCCCGAGGCGGAGAACAGGAAGUGGACCAUCAUGGCG GUGAUGGUCAGCCUCCUGACCGACUACUCGCCGCAGCUGCAGAAGCCGAAGU UCUGAUAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGC CUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUU ACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAA GAAAGUUUCUUCACAUUCUAG >mARM1884 (SEQ ID NO: 96) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGGUGUUCAACCUCCGCAUC CUCCUCAACAACGCCGCAUUCAGAAACGGGCACAACUUCAUGGUCAGAAACU UCCGCUGCGGGCAACCCCUACAAAACCGGGUCCAGCUCAAGGGGCGGGACCU CCUGACCCUGAAGAACUUCACCGGCGAAGAGAUCCGGUACAUGCUGUGGCUC UCCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGAGAGUACCUCCCGCUGC UGCAAGGGAAGUCGCUGGGGAUGAUCUUCGAGAAGCGGUCAACCAGAACCCG GCUGUCAACCGAAACCGGGUUCGCACUGCUGGGGGGACACCCGUGCUUCCUG ACCACCCAAGACAUCCACCUGGGAGUGAACGAAUCGCUGACCGACACCGCCC GCGUGCUGAGCUCAAUGGCGGACGCCGUGCUGGCCCGCGUGUACAAGCAGUC CGACCUGGACACCCUGGCCAAGGAAGCGUCCAUCCCGAUCAUCAACGGACUG UCCGACCUGUACCACCCGAUCCAGAUCCUGGCAGACUACCUGACCCUGCAAG AACACUACAGCUCCCUGAAGGGCCUGACCCUGUCAUGGAUCGGGGACGGGAA CAACAUCCUGCACUCCAUAAUGAUGUCAGCCGCCAAGUUCGGAAUGCACCUC CAAGCCGCAACCCCGAAGGGCUACGAACCGGACGCAUCAGUGACCAAACUGG CCGAGCAGUACGCCAAGGAAAACGGCACCAAGCUCCUGCUGACCAACGACCC GCUGGAGGCCGCACACGGGGGGAACGUGCUGAUCACCGACACCUGGAUCUCC AUGGGACAGGAGGAGGAAAAGAAGAAGCGGCUGCAGGCGUUCCAGGGGUAC CAGGUCACCAUGAAAACCGCGAAGGUCGCGGCAUCAGACUGGACCUUCCUGC ACUGCCUGCCCCGGAAGCCGGAAGAGGUGGACGACGAGGUGUUCUACUCGCC GCGCUCGCUGGUGUUCCCCGAGGCGGAGAACAGGAAGUGGACCAUCAUGGCG GUGAUGGUCAGCCUCCUGACCGACUACUCGCCGCAGCUGCAGAAGCCGAAGU UCUGAUAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGC CUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUU ACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAA GAAAGUUUCUUCACAUUCUAG >mARM1885 (SEQ ID NO: 97) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGGUCAACCUCCGCAUC CUCCUCAACAACGCCGCAUUCAGAAACGGGCACAACUUCAUGGUCAGAAACU UCCGCUGCGGGCAACCCCUACAAAACAAGGUCCAGCUCAAGGGGCGGGACCU CCUGACCCUGAAGAACUUCACCGGCGAAGAGAUCAAGUACAUGCUGUGGCUC UCCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGAGAGUACCUCCCGCUGC UGCAAGGGAAGUCGCUGGGGAUGAUCUUCGAGAAGCGGUCAACCAGAACCCG GCUGUCAACCGAAACCGGGUUCGCACUGCUGGGGGGACACCCGUGCUUCCUG ACCACCCAAGACAUCCACCUGGGAGUGAACGAAUCGCUGACCGACACCGCCC GCGUGCUGAGCUCAAUGGCGGACGCCGUGCUGGCCCGCGUGUACAAGCAGUC CGACCUGGACACCCUGGCCAAGGAAGCGUCCAUCCCGAUCAUCAACGGACUG UCCGACCUGUACCACCCGAUCCAGAUCCUGGCAGACUACCUGACCCUGCAAG AACACUACAGCUCCCUGAAGGGCCUGACCCUGUCAUGGAUCGGGGACGGGAA CAACAUCCUGCACUCCAUAAUGAUGUCAGCCGCCAAGUUCGGAAUGCACCUC CAAGCCGCAACCCCGAAGGGCUACGAACCGGACGCAUCAGUGACCAAACUGG CCGAGCAGUACGCCAAGGAAAACGGCACCAAGCUCCUGCUGACCAACGACCC GCUGGAGGCCGCACACGGGGGGAACGUGCUGAUCACCGACACCUGGAUCUCC AUGGGACAGGAGGAGGAAAAGAAGAAGCGGCUGCAGGCGUUCCAGGGGUAC CAGGUCACCAUGAAAACCGCGAAGGUCGCGGCAUCAGACUGGACCUUCCUGC ACUGCCUGCCCCGGAAGCCGGAAGAGGUGGACGACGAGGUGUUCUACUCGCC GCGCUCGCUGGUGUUCCCCGAGGCGGAGAACAGGAAGUGGACCAUCAUGGCG GUGAUGGUCAGCCUCCUGACCGACUACUCGCCGCAGCUGCAGAAGCCGAAGU UCUGAUAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGC CUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUU ACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAA GAAAGUUUCUUCACAUUCUAG >mARM1886 (SEQ ID NO: 98) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGGUCAACCUCCGCAUC CUCCUCAACAACGCCGCAUUCAGAAACGGGCACAACUUCAUGGUCAGAAACU UCCGCUGCGGGCAACCCCUACAAAACCGGGUCCAGCUCAAGGGGCGGGACCU CCUGACCCUGAAGAACUUCACCGGCGAAGAGAUCAAGUACAUGCUGUGGCUC UCCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGAGAGUACCUCCCGCUGC UGCAAGGGAAGUCGCUGGGGAUGAUCUUCGAGAAGCGGUCAACCAGAACCCG GCUGUCAACCGAAACCGGGUUCGCACUGCUGGGGGGACACCCGUGCUUCCUG ACCACCCAAGACAUCCACCUGGGAGUGAACGAAUCGCUGACCGACACCGCCC GCGUGCUGAGCUCAAUGGCGGACGCCGUGCUGGCCCGCGUGUACAAGCAGUC CGACCUGGACACCCUGGCCAAGGAAGCGUCCAUCCCGAUCAUCAACGGACUG UCCGACCUGUACCACCCGAUCCAGAUCCUGGCAGACUACCUGACCCUGCAAG AACACUACAGCUCCCUGAAGGGCCUGACCCUGUCAUGGAUCGGGGACGGGAA CAACAUCCUGCACUCCAUAAUGAUGUCAGCCGCCAAGUUCGGAAUGCACCUC CAAGCCGCAACCCCGAAGGGCUACGAACCGGACGCAUCAGUGACCAAACUGG CCGAGCAGUACGCCAAGGAAAACGGCACCAAGCUCCUGCUGACCAACGACCC GCUGGAGGCCGCACACGGGGGGAACGUGCUGAUCACCGACACCUGGAUCUCC AUGGGACAGGAGGAGGAAAAGAAGAAGCGGCUGCAGGCGUUCCAGGGGUAC CAGGUCACCAUGAAAACCGCGAAGGUCGCGGCAUCAGACUGGACCUUCCUGC ACUGCCUGCCCCGGAAGCCGGAAGAGGUGGACGACGAGGUGUUCUACUCGCC GCGCUCGCUGGUGUUCCCCGAGGCGGAGAACAGGAAGUGGACCAUCAUGGCG GUGAUGGUCAGCCUCCUGACCGACUACUCGCCGCAGCUGCAGAAGCCGAAGU UCUGAUAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGC CUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUU ACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAA GAAAGUUUCUUCACAUUCUAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAA >mARM1887 (SEQ ID NO: 99) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGGUCAACCUCCGCAUC CUCCUCAACAACGCCGCAUUCAGAAACGGGCACAACUUCAUGGUCAGAAACU UCCGCUGCGGGCAACCCCUACAAAACCGGGUCCAGCUCAAGGGGCGGGACCU CCUGACCCUGAAGAACUUCACCGGCGAAGAGAUCCGGUACAUGCUGUGGCUC UCCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGAGAGUACCUCCCGCUGC UGCAAGGGAAGUCGCUGGGGAUGAUCUUCGAGAAGCGGUCAACCAGAACCCG GCUGUCAACCGAAACCGGGUUCGCACUGCUGGGGGGACACCCGUGCUUCCUG ACCACCCAAGACAUCCACCUGGGAGUGAACGAAUCGCUGACCGACACCGCCC GCGUGCUGAGCUCAAUGGCGGACGCCGUGCUGGCCCGCGUGUACAAGCAGUC CGACCUGGACACCCUGGCCAAGGAAGCGUCCAUCCCGAUCAUCAACGGACUG UCCGACCUGUACCACCCGAUCCAGAUCCUGGCAGACUACCUGACCCUGCAAG AACACUACAGCUCCCUGAAGGGCCUGACCCUGUCAUGGAUCGGGGACGGGAA CAACAUCCUGCACUCCAUAAUGAUGUCAGCCGCCAAGUUCGGAAUGCACCUC CAAGCCGCAACCCCGAAGGGCUACGAACCGGACGCAUCAGUGACCAAACUGG CCGAGCAGUACGCCAAGGAAAACGGCACCAAGCUCCUGCUGACCAACGACCC GCUGGAGGCCGCACACGGGGGGAACGUGCUGAUCACCGACACCUGGAUCUCC AUGGGACAGGAGGAGGAAAAGAAGAAGCGGCUGCAGGCGUUCCAGGGGUAC CAGGUCACCAUGAAAACCGCGAAGGUCGCGGCAUCAGACUGGACCUUCCUGC ACUGCCUGCCCCGGAAGCCGGAAGAGGUGGACGACGAGGUGUUCUACUCGCC GCGCUCGCUGGUGUUCCCCGAGGCGGAGAACAGGAAGUGGACCAUCAUGGCG GUGAUGGUCAGCCUCCUGACCGACUACUCGCCGCAGCUGCAGAAGCCGAAGU UCUGAUAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGC CUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUU ACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAA GAAAGUUUCUUCACAUUCUAG >mARM1888 (SEQ ID NO: 100) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGGUCAACCUGCGCAUC CUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCGCAACU UCCGCUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGGCCGCGACCU GCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUGCUGUGGCUG AGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCCCCUGC UGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGCACCCG CCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCUGCUUCCUG ACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACCGCCC GCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGCAGAG CGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGGCCUG AGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGCAGG AGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGCAA CAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCACCUG CAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCUGGC CGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGACCCC CUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCAGCA UGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUACCA GGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUGCAC UGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCCCCC GCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGCCGU GAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAGUUC UGAUAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCU CAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUAC AAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGA AAGUUUCUUCACAUUCUAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAA >mARM1889 (SEQ ID NO: 101) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUGGUCAACCUGCGCAUC CUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCGCAACU UCCGCUGCGGCCAGCCCCUGCAGAACCGGGUGCAGCUGAAGGGCCGCGACCU GCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUGCUGUGGCUG AGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCCCCUGC UGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGCACCCG CCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCUGCUUCCUG ACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACCGCCC GCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGCAGAG CGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGGCCUG AGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGCAGG AGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGCAA CAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCACCUG CAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCUGGC CGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGACCCC CUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCAGCA UGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUACCA GGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUGCAC UGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCCCCC GCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGCCGU GAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAGUUC UGAUAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCU CAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUAC AAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGA AAGUUUCUUCACAUUCUAG >mARM1890 (SEQ ID NO: 102) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUGUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAAAACAAGGUCCAGCUGAAGGGCCGGGAUCU UCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGGCUC UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCC GGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGCCUU AGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGGCAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAUCUU CAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC ACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCUGC ACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC ACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM1891 (SEQ ID NO: 103) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGCUUGUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAAAACCGGGUCCAGCUGAAGGGCCGGGAUCU UCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGGCUC UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCC GGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGCCUU AGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGGCAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAUCUU CAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC ACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCUGC ACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC ACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGU UCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCCUC AAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUACA AAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAGAA AGUUUCUUCACAUUCUAG >mARM1898 (SEQ ID NO: 104) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGGGCCUUGUCAAUCUCCGC AUCCUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGA ACUUCAGAUGUGGCCAGCCGCUUCAAAACAAGGUCCAGCUGAAGGGCCGGGA UCUUCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGG CUCUCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGC UGCUUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGAC CCGCCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUC CUGACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCG CCCGGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACA GUCCGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGC CUUAGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCUGC AAGAACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGG CAACAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAU CUUCAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAAGC UCGCCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGA CCCACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUC UCCAUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAU AUCAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCU GCACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCG CCACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGG CCGUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAA GUUCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCC UCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUA CAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAG AAAGUUUCUUCACAUUCUAG >mARM1899 (SEQ ID NO: 105) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGGGCCUUGUCAAUCUCCGC AUCCUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGA ACUUCAGAUGUGGCCAGCCGCUUCAAAACCGGGUCCAGCUGAAGGGCCGGGA UCUUCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGG CUCUCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGC UGCUUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGAC CCGCCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUC CUGACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCG CCCGGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACA GUCCGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGC CUUAGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCUGC AAGAACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGG CAACAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAU CUUCAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAAGC UCGCCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGA CCCACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUC UCCAUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAU AUCAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCU GCACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCG CCACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGG CCGUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAA GUUCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCAGCC UCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACACUUA CAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAAAAG AAAGUUUCUUCACAUUCUAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA >mARM1900 (SEQ ID NO: 106) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGGGCGGACUUGUCAAUCUC CGCAUCCUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCC GGAACUUCAGAUGUGGCCAGCCGCUUCAAAACAAGGUCCAGCUGAAGGGCCG GGAUCUUCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUC UGGCUCUCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUC CGCUGCUUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAG GACCCGCCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGC UUCCUGACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUA CCGCCCGGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAA ACAGUCCGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAAC GGCCUUAGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCC UGCAAGAACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGA CGGCAACAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUG CAUCUUCAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUA AGCUCGCCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAA CGACCCACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGG AUCUCCAUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGG GAUAUCAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUU CCUGCACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUAC UCGCCACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCA UGGCCGUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCC CAAGUUCUAGCUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAAACCA GCCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUUACAC UUACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAAUAAA AAGAAAGUUUCUUCACAUUCUAG >mARM1903 (SEQ ID NO: 107) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCAUGGCCCUUUUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAAGGCAAGGUCCAGCUGAAGGGCCGGGAUCU UCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGGCUC UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCC GGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGCCUU AGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGGCAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAUCUU CAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC ACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCUGC ACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC ACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGU UCUAGAUAAGUGAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAA ACCAGCCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUU ACACUUACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAA UAAAAAGAAAGUUUCUUCACAUUCUAG >mARM1904 (SEQ ID NO: 108) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCAUGGCCCUUUUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAAGGCCGGGUCCAGCUGAAGGGCCGGGAUCU UCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGGCUC UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCC GGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGCCUU AGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGGCAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAUCUU CAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC ACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCUGC ACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC ACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGU UCUAGAUAAGUGAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAA ACCAGCCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUU ACACUUACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAA UAAAAAGAAAGUUUCUUCACAUUCUAG >mARM1905 (SEQ ID NO: 109) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCAUGGCCCUUUUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAAGGCCGGGUCCAGCUGAAGGGCCGGGAUCU UCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAGGUACAUGCUCUGGCUC UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCC GGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGCCUU AGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGGCAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAUCUU CAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC ACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCUGC ACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC ACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGU UCUAGAUAAGUGAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAA ACCAGCCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUU ACACUUACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAA UAAAAAGAAAGUUUCUUCACAUUCUAG >mARM1906 (SEQ ID NO: 110) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCAUGGCCCUUGUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAAGGCAGGGUCCAGCUGAAGGGCCGGGAUCU UCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGGCUC UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCC GGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGCCUU AGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGGCAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAUCUU CAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC ACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCUGC ACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC ACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGU UCUAAGUGAAUAGACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAA ACCAGCCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUU ACACUUACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAA UAAAAAGAAAGUUUCUUCACAUUCUAG >mARM1907 (SEQ ID NO: 111) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCAUGGCCCUUUUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAAGUCAAGGUCCAGCUGAAGGGCCGGGAUCU UCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGGCUC UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCC GGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGCCUU AGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGGCAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAUCUU CAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC ACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCUGC ACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC ACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGU UCUAGAUAAGUGAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAA ACCAGCCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUU ACACUUACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAA UAAAAAGAAAGUUUCUUCACAUUCUAGAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA >mARM1908 (SEQ ID NO: 112) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCAUGGCCCUUUUCAAUCUCCGCAUC CUCCUUAACAACGCCGCGUUUAGAAACGGCCACAACUUCAUGGUCCGGAACU UCAGAUGUGGCCAGCCGCUUCAAGUCAGGGUCCAGCUGAAGGGCCGGGAUCU UCUGACCCUGAAGAACUUUACUGGCGAAGAGAUCAAGUACAUGCUCUGGCUC UCCGCGGACUUGAAGUUCCGCAUUAAGCAGAAGGGGGAAUACCUUCCGCUGC UUCAAGGAAAGAGCCUCGGCAUGAUCUUUGAGAAGCGCUCAACCAGGACCCG CCUUUCUACUGAAACUGGGUUCGCGCUGCUCGGUGGCCACCCCUGCUUCCUG ACGACCCAGGACAUCCACCUCGGAGUGAACGAAUCCCUCACCGAUACCGCCC GGGUGUUAUCGAGCAUGGCAGAUGCCGUGCUGGCCAGGGUGUACAAACAGUC CGAUCUGGACACUCUGGCCAAGGAGGCGUCAAUUCCUAUUAUCAACGGCCUU AGUGACCUCUACCAUCCGAUUCAGAUCCUGGCCGAUUACCUCACCCUGCAAG AACACUACAGCUCCCUGAAGGGUCUGACAUUGUCCUGGAUCGGCGACGGCAA CAACAUUCUCCAUUCCAUCAUGAUGUCCGCCGCAAAAUUCGGCAUGCAUCUU CAAGCCGCCACGCCGAAGGGUUACGAGCCCGACGCUUCCGUGACUAAGCUCG CCGAGCAGUACGCUAAGGAGAACGGAACCAAGCUUCUGCUGACUAACGACCC ACUAGAAGCAGCCCACGGGGGCAACGUGCUUAUUACUGACACCUGGAUCUCC AUGGGCCAGGAAGAAGAGAAAAAGAAGCGGCUGCAGGCGUUCCAGGGAUAU CAGGUCACCAUGAAAACCGCCAAGGUCGCUGCCUCCGACUGGACCUUCCUGC ACUGCCUGCCUCGCAAGCCUGAAGAAGUGGACGACGAGGUGUUCUACUCGCC ACGGAGCCUCGUGUUCCCCGAGGCCGAGAAUAGAAAGUGGACCAUCAUGGCC GUGAUGGUGUCACUGCUCACCGACUACAGCCCGCAGCUUCAGAAGCCCAAGU UCUAGAUAAGUGAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACUAA ACCAGCCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAACUU ACACUUACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCUAA UAAAAAGAAAGUUUCUUCACAUUCUAG >mARM1915 (SEQ ID NO: 113) GGCAGAAAAAUUUGCUACAUUGUUUCACAAACUUCAAAUAUUAUUCAUUUA UUUAGAUCUAUUAUUACAUCAAAACAAAAAGCCGCCACCAUGCUGUUCAACC UGCGCAUCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGU GCGCAACUUCCGCUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGGC CGCGACCUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUGC UGUGGCUGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCU GCCCCUGCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACC CGCACCCGCCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCUG CUUCCUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGAC ACCGCCCGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACA AGCAGAGCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAA CGGCCUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCC UGCAGGAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGA CGGCAACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUG CACCUGCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAA GCUGGCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAAC GACCCCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGA UCAGCAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGG CUACCAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUC CUGCACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACA GCCCCCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAU GGCCGUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCC AAGUUCUGAGGUCUCUAGUAAUGAGCUGGAGCCUCGGUAGCCGUUCCUCCUG CCCGCUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUCCUG GUCUUUGAAUAAAGUCUGAGUGGGCAUCUAG >mARM1916 (SEQ ID NO: 114) GGCAGAAAAAUUUGCUACAUUGUUUCACAAACUUCAAAUAUUAUUCAUUUA UUUAGAUCUAUUAUUACAUCAAAACAAAAAGCCGCCACCAUGGGAGUAUUCA ACCUGCGCAUCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAU GGUGCGCAACUUCCGCUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAG GGCCGCGACCUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACA UGCUGUGGCUGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUA CCUGCCCCUGCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGC ACCCGCACCCGCCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCC CUGCUUCCUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACC GACACCGCCCGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGU ACAAGCAGAGCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAU CAACGGCCUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUG ACCCUGCAGGAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCG GCGACGGCAACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGG CAUGCACCUGCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGA CCAAGCUGGCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGAC CAACGACCCCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCU GGAUCAGCAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCA GGGCUACCAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACC UUCCUGCACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCU ACAGCCCCCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAU CAUGGCCGUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAG CCCAAGUUCUGAGGUCUCUAGUAAUGAGCUGGAGCCUCGGUAGCCGUUCCUC CUGCCCGCUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUC CUGGUCUUUGAAUAAAGUCUGAGUGGGCAUCUAG >mARM1917 (SEQ ID NO: 115) GGCAGAAAAAUUUGCUACAUUGUUUCACAAACUUCAAAUAUUAUUCAUUUA UUUAGAUCUAUUAUUACAUCAAAACAAAAAGCCGCCACCAUGGGAGUAUUCA ACCUGCGCAUCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAU GGUGCGCAACUUCCGCUGCGGCCAGCCCCUGCAGAACCGGGUGCAGCUGAAG GGCCGCGACCUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCCGGUACA UGCUGUGGCUGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUA CCUGCCCCUGCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGC ACCCGCACCCGCCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCC CUGCUUCCUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACC GACACCGCCCGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGU ACAAGCAGAGCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAU CAACGGCCUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUG ACCCUGCAGGAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCG GCGACGGCAACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGG CAUGCACCUGCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGA CCAAGCUGGCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGAC CAACGACCCCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCU GGAUCAGCAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCA GGGCUACCAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACC UUCCUGCACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCU ACAGCCCCCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAU CAUGGCCGUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAG CCCAAGUUCUGAGGUCUCUAGUAAUGAGCUGGAGCCUCGGUAGCCGUUCCUC CUGCCCGCUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUC CUGGUCUUUGAAUAAAGUCUGAGUGGGCAUCUAG >mARM1918 (SEQ ID NO: 116) GGCAGAAAAAUUUGCUACAUUGUUUCACAAACUUCAAAUAUUAUUCAUUUA UUUAGAUCUAUUAUUACAUCAAAACAAAAAGCCGCCACCAUGCUGGUAUUCA ACCUGCGCAUCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAU GGUGCGCAACUUCCGCUGCGGCCAGCCCCUGCAGAACCGGGUGCAGCUGAAG GGCCGCGACCUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCCGGUACA UGCUGUGGCUGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUA CCUGCCCCUGCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGC ACCCGCACCCGCCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCC CUGCUUCCUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACC GACACCGCCCGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGU ACAAGCAGAGCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAU CAACGGCCUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUG ACCCUGCAGGAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCG GCGACGGCAACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGG CAUGCACCUGCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGA CCAAGCUGGCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGAC CAACGACCCCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCU GGAUCAGCAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCA GGGCUACCAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACC UUCCUGCACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCU ACAGCCCCCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAU CAUGGCCGUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAG CCCAAGUUCUGAGGUCUCUAGUAAUGAGCUGGAGCCUCGGUAGCCGUUCCUC CUGCCCGCUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUC CUGGUCUUUGAAUAAAGUCUGAGUGGGCAUCUAG >mARM1919 (SEQ ID NO: 117) AUUAUUACAUCAAAACAAAAAGCCGCCACCAUGGGAGUAUUCAACCUGCGCA UCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCGCAA CUUCCGCUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGGCCGCGAC CUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUGCUGUGGC UGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCCCCU GCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGCACC CGCCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCUGCUUCCU GACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACCGCC CGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGCAGA GCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGGCCU GAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGCAG GAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGCA ACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCACCU GCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCUG GCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGACC CCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCAG CAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUAC CAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUGC ACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCCC CCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGCC GUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAGU UCUGAGGUCUCUAGUAAUGAGCUGGAGCCUCGGUAGCCGUUCCUCCUGCCCG CUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUCCUGGUCU UUGAAUAAAGUCUGAGUGGGCAUCUAG >mARM1920 (SEQ ID NO: 118) AUUAUUACAUCAAAACAAAAAGCCGCCACCAUGGGAGUAUUCAACCUGCGCA UCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCGCAA CUUCCGCUGCGGCCAGCCCCUGCAGAACCGGGUGCAGCUGAAGGGCCGCGAC CUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCCGGUACAUGCUGUGGC UGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCCCCU GCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGCACC CGCCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCUGCUUCCU GACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACCGCC CGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGCAGA GCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGGCCU GAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGCAG GAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGCA ACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCACCU GCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCUG GCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGACC CCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCAG CAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUAC CAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUGC ACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCCC CCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGCC GUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAGU UCUGAGGUCUCUAGUAAUGAGCUGGAGCCUCGGUAGCCGUUCCUCCUGCCCG CUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUCCUGGUCU UUGAAUAAAGUCUGAGUGGGCAUCUAG >mARM1921 (SEQ ID NO: 119) AUUAUUACAUCAAAACAAAAAGCCGCCACCAUGCUGGUAUUCAACCUGCGCA UCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCGCAA CUUCCGCUGCGGCCAGCCCCUGCAGAACCGGGUGCAGCUGAAGGGCCGCGAC CUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCCGGUACAUGCUGUGGC UGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCCCCU GCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGCACC CGCCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCUGCUUCCU GACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACCGCC CGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGCAGA GCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGGCCU GAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGCAG GAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGCA ACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCACCU GCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCUG GCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGACC CCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCAG CAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUAC CAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUGC ACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCCC CCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGCC GUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAGU UCUGAGGUCUCUAGUAAUGAGCUGGAGCCUCGGUAGCCGUUCCUCCUGCCCG CUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUCCUGGUCU UUGAAUAAAGUCUGAGUGGGCAUCUAG >mARM1925 (SEQ ID NO: 120) UCAACACAACAUAUACAAAACAAACGAAUCUCAAGCAAUCAAGCAUUCUACU UCUAUUGCAGCAAUUUAAAUCAUUUCUUUUAAAGCAAAAGCAAUUUUCUGA AAAUUUUCACCAUUUACGAACGAUAGCCACCAUGUUGUUCAACUUGAGGAUC UUGUUGAACAACGCCGCCUUCAGGAACGGACACAACUUCAUGGUAAGGAACU UCAGGUGCGGACAGCCCUUGCAGAACAAAGUACAGUUGAAAGGAAGGGACUU GUUGACAUUGAAAAACUUCACAGGAGAAGAAAUCAAAUACAUGUUGUGGUU GUCGGCCGACUUGAAAUUCAGGAUCAAACAGAAAGGAGAAUACUUGCCCUUG UUGCAGGGAAAAUCGUUGGGAAUGAUCUUCGAAAAAAGGUCGACAAGGACA AGGUUGUCGACAGAAACAGGAUUCGCCUUGUUGGGAGGACACCCCUGCUUCU UGACAACACAGGACAUCCACUUGGGAGUAAACGAAUCGUUGACAGACACAGC CAGGGUAUUGUCGUCGAUGGCCGACGCCGUAUUGGCCAGGGUAUACAAACAG UCGGACUUGGACACAUUGGCCAAAGAAGCCUCGAUCCCCAUCAUCAACGGAU UGUCGGACUUGUACCACCCCAUCCAGAUCUUGGCCGACUACUUGACAUUGCA GGAACACUACUCGUCGUUGAAAGGAUUGACAUUGUCGUGGAUCGGAGACGG AAACAACAUCUUGCACUCGAUCAUGAUGUCGGCCGCCAAAUUCGGAAUGCAC UUGCAGGCCGCCACACCCAAAGGAUACGAACCCGACGCCUCGGUAACAAAAU UGGCCGAACAGUACGCCAAAGAAAACGGAACAAAAUUGUUGUUGACAAACGA CCCCUUGGAAGCCGCCCACGGAGGAAACGUAUUGAUCACAGACACAUGGAUC UCGAUGGGACAGGAAGAAGAAAAAAAAAAAAGGUUGCAGGCCUUCCAGGGA UACCAGGUAACAAUGAAAACAGCCAAAGUAGCCGCCUCGGACUGGACAUUCU UGCACUGCUUGCCCAGGAAACCCGAAGAAGUAGACGACGAAGUAUUCUACUC GCCCAGGUCGUUGGUAUUCCCCGAAGCCGAAAACAGGAAAUGGACAAUCAUG GCCGUAAUGGUAUCGUUGUUGACAGACUACUCGCCCCAGUUGCAGAAACCCA AAUUCUGAAUAGUGAACUCGAGCUAGUGACUGACUAGGAUCUGGUUACCACU AAACCAGCCUCAAGAACACCCGAAUGGAGUCUCUAAGCUACAUAAUACCAAC UUACACUUACAAAAUGUUGUCCCCCAAAAUGUAGCCAUUCGUAUCUGCUCCU AAUAAAAAGAAAGUUUCUUCACAUUCUAG >mARM1926 (SEQ ID NO: 121) AUUAUUACAUCAAAACAAAAAGCCGCCACCAUGCUGUUCAACCUGCGCAUCC UGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCGCAACUU CCGCUGCGGCCAGCCCCUGCAGGGCAAGGUGCAGCUGAAGGGCCGCGACCUG CUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUGCUGUGGCUGA GCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCCCCUGCU GCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGCACCCGC CUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCUGCUUCCUGA CCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACCGCCCGC GUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGCAGAGCG ACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGGCCUGAG CGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGCAGGAGC ACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGCAACAA CAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCACCUGCAG GCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCUGGCCGA GCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGACCCCCUG GAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCAGCAUGG GCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUACCAGGU GACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUGCACUGC CUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCCCCCGCA GCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGCCGUGAU GGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAGUUCUGA GGUCUCUAGUAAUGAGCUGGAGCCUCGGUAGCCGUUCCUCCUGCCCGCUGGG CCUCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUCCUGGUCUUUGAA UAAAGUCUGAGUGGGCAUCUAG >mARM1927 (SEQ ID NO: 122) AUUAUUACAUCAAAACAAAAAGCCGCCACCAUGCUGUUCAACCUGCGCAUCC UGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCGCAACUU CCGCUGCGGCCAGCCCCUGCAGGGCCGGGUGCAGCUGAAGGGCCGCGACCUG CUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUGCUGUGGCUGA GCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCCCCUGCU GCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGCACCCGC CUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCUGCUUCCUGA CCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACCGCCCGC GUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGCAGAGCG ACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGGCCUGAG CGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGCAGGAGC ACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGCAACAA CAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCACCUGCAG GCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCUGGCCGA GCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGACCCCCUG GAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCAGCAUGG GCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUACCAGGU GACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUGCACUGC CUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCCCCCGCA GCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGCCGUGAU GGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAGUUCUGA GGUCUCUAGUAAUGAGCUGGAGCCUCGGUAGCCGUUCCUCCUGCCCGCUGGG CCUCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUCCUGGUCUUUGAA UAAAGUCUGAGUGGGCAUCUAG >mARM1928 (SEQ ID NO: 123) AUUAUUACAUCAAAACAAAAAGCCGCCACCAUGCUGUUCAACCUGCGCAUCC UGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCGCAACUU CCGCUGCGGCCAGCCCCUGCAGGGCCGGGUGCAGCUGAAGGGCCGCGACCUG CUGACCCUGAAGAACUUCACCGGCGAGGAGAUCCGGUACAUGCUGUGGCUGA GCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCCCCUGCU GCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGCACCCGC CUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCUGCUUCCUGA CCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACCGCCCGC GUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGCAGAGCG ACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGGCCUGAG CGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGCAGGAGC ACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGCAACAA CAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCACCUGCAG GCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCUGGCCGA GCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGACCCCCUG GAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCAGCAUGG GCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUACCAGGU GACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUGCACUGC CUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCCCCCGCA GCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGCCGUGAU GGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAGUUCUGA GGUCUCUAGUAAUGAGCUGGAGCCUCGGUAGCCGUUCCUCCUGCCCGCUGGG CCUCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUCCUGGUCUUUGAA UAAAGUCUGAGUGGGCAUCUAG >mARM1929 (SEQ ID NO: 124) GGCAGAAAAAUUUGCUACAUUGUUUCACAAACUUCAAAUAUUAUUCAUUUA UUUAGAUCUAUUAUUACAUCAAAACAAAAAGCCGCCACCAUGCUGUUCAACC UGCGCAUCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGU GCGCAACUUCCGCUGCGGCCAGCCCCUGCAGGGCAAGGUGCAGCUGAAGGGC CGCGACCUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUGC UGUGGCUGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCU GCCCCUGCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACC CGCACCCGCCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCUG CUUCCUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGAC ACCGCCCGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACA AGCAGAGCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAA CGGCCUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCC UGCAGGAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGA CGGCAACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUG CACCUGCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAA GCUGGCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAAC GACCCCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGA UCAGCAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGG CUACCAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUC CUGCACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACA GCCCCCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAU GGCCGUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCC AAGUUCUGAGGUCUCUAGUAAUGAGCUGGAGCCUCGGUAGCCGUUCCUCCUG CCCGCUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUCCUG GUCUUUGAAUAAAGUCUGAGUGGGCAUCUAG AT1G67090> (SEQ ID NO: 125) CACAAAGAGUAAAGAAGAACA AT1G35720> (SEQ ID NO: 126) AACACUAAAAGUAGAAGAAAA AT5G45900> (SEQ ID NO: 127) CUCAGAAAGAUAAGAUCAGCC >pARM563 (SEQ ID NO: 128) ATGCTGTTTAATCTGAGGATCCTGTTAAACAATGCAGCTTTTAGAAATGGTCAC AACTTCATGGTTCGAAATTTTCGGTGTGGACAACCACTACAAAATAAAGTGCAG CTGAAGGGCCGTGACCTTCTCACTCTAAAAAACTTTACCGGAGAAGAAATTAAA TATATGCTATGGCTATCAGCAGATCTGAAATTTAGGATAAAACAGAAAGGAGA GTATTTGCCTTTATTGCAAGGGAAGTCCTTAGGCATGATTTTTGAGAAAAGAAG TACTCGAACAAGATTGTCTACAGAAACAGGCTTTGCACTTCTGGGAGGACATCC TTGTTTTCTTACCACACAAGATATTCATTTGGGTGTGAATGAAAGTCTCACGGA CACGGCCCGTGTATTGTCTAGCATGGCAGATGCAGTATTGGCTCGAGTGTATAA ACAATCAGATTTGGACACCCTGGCTAAAGAAGCATCCATCCCAATTATCAATGG GCTGTCAGATTTGTACCATCCTATCCAGATCCTGGCTGATTACCTCACGCTCCAG GAACACTATAGCTCTCTGAAAGGTCTTACCCTCAGCTGGATCGGGGATGGGAAC AATATCCTGCACTCCATCATGATGAGCGCAGCGAAATTCGGAATGCACCTTCAG GCAGCTACTCCAAAGGGTTATGAGCCGGATGCTAGTGTAACCAAGTTGGCAGA GCAGTATGCCAAAGAGAATGGTACCAAGCTGTTGCTGACAAATGATCCATTGG AAGCAGCGCATGGAGGCAATGTATTAATTACAGACACTTGGATAAGCATGGGA CAAGAAGAGGAGAAGAAAAAGCGGCTCCAGGCTTTCCAAGGTTACCAGGTTAC AATGAAGACTGCTAAAGTTGCTGCCTCTGACTGGACATTTTTACACTGCTTGCC CAGAAAGCCAGAAGAAGTGGATGATGAAGTCTTTTATTCTCCTCGATCACTAGT GTTCCCAGAGGCAGAAAACAGAAAGTGGACAATCATGGCTGTCATGGTGTCCC TGCTGACAGATTACTCACCTCAGCTCCAGAAGCCTAAATTTTGA >pARM564 (SEQ ID NO: 129) ATGCTCTTTAATCTGCGCATCTTACTGAACAACGCCGCATTCCGGAACGGTCAC AACTTCATGGTCCGCAATTTCCGCTGTGGCCAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGACGGGATCTGCTGACACTGAAGAACTTCACCGGAGAAGAGATCAA GTACATGCTGTGGCTCAGCGCAGACTTGAAGTTCCGGATCAAGCAGAAGGGAG AATACTTGCCCCTGCTGCAAGGAAAGTCGCTGGGAATGATTTTTGAGAAGCGGT CAACTCGCACCAGACTCTCCACCGAAACTGGTTTCGCACTGCTTGGCGGGCACC CTTGCTTCCTGACGACTCAGGACATCCACCTCGGCGTGAACGAATCGCTAACCG ATACCGCCAGAGTGCTTTCTTCCATGGCCGACGCGGTGCTGGCCAGGGTGTACA AGCAGTCCGACCTCGATACCTTGGCAAAGGAGGCTTCCATTCCCATCATCAACG GCCTGAGCGACCTGTACCACCCAATCCAAATCCTGGCTGACTACCTGACCCTGC AAGAGCACTACAGCAGCCTGAAGGGTCTGACCCTGTCATGGATTGGCGATGGA AACAATATTCTGCACTCCATCATGATGTCCGCCGCGAAGTTCGGAATGCATCTG CAAGCCGCCACTCCAAAAGGATACGAACCGGATGCGTCCGTGACCAAGTTGGC GGAACAGTACGCGAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCCC TCGAGGCTGCGCATGGGGGCAACGTGCTGATTACCGACACCTGGATCTCCATGG GGCAGGAGGAAGAGAAGAAGAAGAGACTGCAGGCATTCCAGGGGTACCAGGT CACCATGAAAACCGCAAAAGTGGCAGCTTCGGACTGGACTTTCCTGCATTGCCT GCCGAGGAAGCCGGAGGAAGTCGACGACGAAGTGTTCTACTCGCCTCGGTCCC TGGTGTTCCCCGAGGCCGAAAACCGGAAGTGGACCATCATGGCCGTGATGGTG TCCTTGCTGACTGACTATAGCCCGCAGCTGCAGAAGCCTAAGTTCTAG >pARM565 (SEQ ID NO: 130) ATGCTGTTTAACCTACGTATTTTGCTCAACAATGCAGCCTTTAGAAACGGACAT AACTTTATGGTTCGAAACTTTCGCTGCGGGCAGCCACTGCAGAACAAGGTCCAG CTGAAAGGGAGAGATTTGCTCACGCTGAAGAACTTTACTGGCGAAGAAATCAA GTATATGCTGTGGTTGTCCGCGGACCTCAAGTTTCGGATTAAGCAGAAAGGGGA GTATCTGCCACTGCTGCAAGGAAAGAGCCTCGGCATGATCTTCGAGAAGCGGA GCACTCGGACCAGGCTGAGTACCGAAACTGGCTTCGCATTGTTGGGTGGACATC CATGTTTTCTGACAACGCAGGACATTCATCTGGGCGTGAACGAGAGTCTGACGG ACACAGCTCGCGTTCTGTCCTCTATGGCTGATGCGGTGTTGGCCCGGGTCTATA AGCAGTCCGATTTGGACACCTTGGCTAAGGAAGCTAGCATACCGATTATCAATG GGCTGTCCGACCTGTATCACCCTATTCAAATCCTGGCCGACTACCTCACACTGC AAGAACACTATAGCTCATTGAAGGGACTGACCCTGAGCTGGATAGGGGACGGA AACAACATCCTACATAGCATTATGATGTCCGCTGCCAAGTTTGGCATGCATCTT CAAGCCGCCACGCCAAAGGGTTATGAGCCCGACGCGTCAGTGACAAAGCTGGC CGAGCAGTACGCTAAGGAGAATGGTACCAAATTACTGCTGACTAATGATCCACT GGAGGCTGCACATGGCGGCAATGTACTGATCACCGACACATGGATCTCGATGG GCCAGGAGGAAGAAAAGAAGAAGAGGCTTCAGGCCTTCCAAGGCTACCAGGTC ACCATGAAAACAGCTAAGGTTGCAGCATCTGATTGGACCTTTCTGCACTGTCTG CCAAGGAAGCCCGAAGAGGTGGACGATGAAGTATTCTATAGCCCACGGAGTTT GGTGTTCCCTGAGGCTGAAAATAGGAAGTGGACAATTATGGCCGTAATGGTGTC CCTGTTAACCGACTACTCTCCGCAACTGCAGAAACCTAAGTTTTAG >pARM566 (SEQ ID NO: 131) ATGCTGTTTAACTTAAGGATCCTGCTGAACAACGCCGCTTTTCGTAACGGTCAT AACTTTATGGTCCGGAACTTTAGATGTGGCCAGCCGCTGCAGAACAAGGTTCAG CTGAAGGGGAGGGATCTGCTGACCTTGAAGAACTTTACCGGCGAAGAGATCAA GTACATGTTGTGGCTGAGCGCCGATCTGAAGTTTAGGATTAAGCAGAAGGGGG AGTATTTGCCACTGCTGCAAGGAAAATCCTTGGGGATGATCTTCGAGAAGCGCT CCACTAGAACCCGGCTAAGCACAGAAACCGGCTTCGCACTTCTGGGTGGACATC CCTGTTTTCTGACGACGCAGGATATACACCTGGGCGTGAATGAGAGTCTGACGG ACACAGCTAGGGTGTTGAGCAGCATGGCCGATGCAGTACTGGCCCGCGTTTATA AGCAGAGCGACTTGGACACACTGGCCAAGGAAGCGTCAATTCCGATTATCAAT GGGCTGTCAGACCTGTATCATCCCATTCAAATCTTGGCTGACTATCTGACCCTGC AAGAACATTACAGCTCCCTGAAGGGCCTCACGTTGTCCTGGATTGGCGACGGAA ACAACATTCTGCATTCGATCATGATGAGCGCTGCTAAGTTTGGCATGCACCTCC AAGCCGCTACACCTAAGGGATATGAGCCTGATGCCAGCGTAACCAAGCTGGCC GAACAGTACGCGAAGGAGAATGGCACGAAACTGCTGTTGACAAATGACCCACT GGAGGCAGCTCACGGTGGCAACGTGCTGATCACCGACACGTGGATATCTATGG GACAGGAAGAAGAGAAGAAGAAGCGGCTGCAGGCATTCCAAGGGTATCAGGT CACCATGAAAACGGCCAAGGTTGCTGCATCCGACTGGACATTTCTGCATTGCTT GCCCCGCAAACCAGAAGAAGTAGACGACGAAGTCTTTTATTCCCCACGGTCGCT GGTGTTCCCCGAGGCGGAGAATCGAAAGTGGACGATTATGGCCGTGATGGTGT CCCTGCTGACTGATTACTCTCCCCAACTGCAAAAGCCTAAGTTTTAG >pARM567 (SEQ ID NO: 132) ATGCTTTTCAACCTGAGGATCCTCCTGAACAACGCCGCCTTTCGCAATGGTCAC AACTTTATGGTCCGGAACTTCAGATGCGGCCAGCCGCTGCAGAACAAGGTCCA GCTGAAGGGACGGGATCTGCTGACTCTGAAGAACTTCACCGGAGAAGAGATCA AGTACATGCTGTGGCTGTCGGCCGACCTGAAGTTCAGGATCAAGCAGAAGGGA GAATACCTCCCGCTGCTGCAAGGAAAGTCCCTGGGCATGATTTTCGAGAAGCGC TCGACCAGAACTCGGTTGTCCACCGAAACCGGGTTTGCGCTGCTGGGCGGACAT CCTTGCTTCCTGACGACTCAGGATATTCACCTGGGAGTGAACGAGTCGCTGACC GACACCGCCAGAGTGCTGAGCTCGATGGCCGACGCCGTGTTGGCACGCGTGTA CAAGCAGTCCGATCTGGATACCCTGGCCAAAGAAGCTTCCATCCCGATCATTAA CGGGCTGAGCGACCTCTACCACCCCATTCAAATCCTGGCCGACTACCTGACTCT GCAAGAACACTACAGCTCGCTGAAGGGGTTGACTCTGTCCTGGATCGGCGACG GAAACAACATCCTGCACTCCATCATGATGTCGGCCGCAAAGTTCGGCATGCATT TGCAAGCCGCCACCCCAAAGGGCTACGAACCAGACGCGAGCGTCACCAAGCTG GCCGAACAGTACGCGAAGGAAAATGGTACTAAGCTGCTGCTGACCAACGACCC ATTGGAAGCTGCCCATGGTGGAAACGTGCTGATCACCGACACCTGGATCTCGAT GGGCCAGGAAGAGGAGAAGAAGAAGCGGCTGCAGGCGTTCCAGGGGTATCAG GTCACCATGAAAACAGCCAAAGTGGCAGCGTCAGACTGGACCTTCCTCCACTGT CTGCCTCGCAAGCCAGAGGAGGTGGACGACGAGGTGTTCTACTCCCCTCGGTCC CTCGTGTTCCCTGAGGCTGAGAACCGGAAGTGGACCATTATGGCCGTGATGGTG TCACTCCTGACTGATTACTCCCCGCAACTGCAGAAGCCCAAGTTCTAG >pARM568 (SEQ ID NO: 133) ATGCTGTTTAACCTGAGGATCCTATTGAACAATGCTGCTTTTCGTAATGGCCATA ACTTTATGGTTCGGAACTTTAGATGCGGGCAGCCACTGCAGAACAAGGTCCAGT TGAAAGGCCGCGATCTGTTGACATTGAAGAACTTTACCGGCGAAGAGATTAAG TATATGCTGTGGCTGTCTGCTGACCTCAAGTTTCGAATCAAGCAGAAGGGCGAA TATCTCCCCCTGCTGCAAGGAAAGTCTCTCGGCATGATCTTTGAGAAGCGGAGT ACCCGAACACGGCTGAGCACCGAAACGGGCTTCGCACTGCTGGGGGGCCATCC CTGTTTTCTGACAACGCAGGACATCCACTTGGGGGTTAACGAATCATTGACTGA TACCGCCCGCGTACTGTCATCCATGGCCGACGCTGTGCTGGCTAGGGTGTACAA GCAGTCAGATCTGGATACACTGGCCAAGGAAGCTAGCATACCAATCATCAATG GACTGAGTGACCTTTATCACCCGATTCAAATACTAGCCGATTATCTGACCCTGC AAGAGCATTACTCCTCGCTGAAAGGCCTCACGCTGTCCTGGATCGGCGACGGCA ACAACATTCTGCATAGTATTATGATGTCTGCTGCCAAATTCGGCATGCATCTGC AAGCTGCTACGCCGAAGGGTTATGAACCCGACGCGTCAGTTACGAAGCTCGCT GAGCAGTATGCAAAGGAGAATGGCACAAAGCTGTTGCTTACCAACGATCCCCT GGAAGCTGCTCATGGCGGCAATGTGCTGATTACTGACACCTGGATTTCAATGGG CCAGGAGGAGGAGAAGAAGAAGAGGTTACAGGCTTTTCAAGGTTACCAAGTCA CGATGAAAACCGCTAAGGTCGCAGCCAGCGACTGGACATTCCTGCACTGTCTGC CAAGAAAGCCGGAAGAAGTGGACGACGAGGTGTTCTATTCCCCGCGGTCTTTG GTGTTTCCGGAGGCCGAAAACAGGAAATGGACCATTATGGCCGTGATGGTATC GTTGCTGACGGACTACAGCCCTCAGTTGCAAAAGCCCAAGTTCTAG >pARM569 (SEQ ID NO: 134) ATGCTCTTTAACCTCCGCATCCTCCTCAACAACGCCGCCTTCCGGAATGGGCAT AACTTCATGGTCCGGAACTTCAGATGCGGCCAGCCCCTGCAAAACAAGGTCCA GTTGAAGGGACGGGACCTCCTTACGCTGAAGAACTTTACCGGAGAAGAGATTA AGTACATGCTGTGGTTGTCCGCTGACCTCAAGTTCCGCATTAAGCAGAAGGGAG AATATCTGCCGCTGCTGCAAGGAAAGAGCCTGGGCATGATCTTCGAAAAGCGC TCCACTAGAACCCGGCTGTCGACTGAGACTGGATTCGCCTTGCTCGGTGGACAC CCGTGCTTCCTGACGACCCAGGACATCCACCTGGGAGTGAACGAGTCACTTACG GATACCGCGAGGGTGCTGTCCTCAATGGCCGACGCAGTGCTCGCGCGCGTGTAC AAGCAGTCAGATCTGGATACCCTGGCCAAGGAAGCCAGCATTCCCATCATCAA CGGACTGAGCGACCTTTACCACCCAATCCAGATCCTCGCCGACTACTTAACCCT GCAAGAGCACTACAGCTCCCTGAAGGGACTGACTCTGTCCTGGATCGGGGATG GAAACAACATCCTGCACTCCATCATGATGTCTGCCGCTAAGTTTGGGATGCATC TGCAAGCCGCAACCCCTAAGGGATACGAGCCCGACGCCTCGGTGACCAAACTT GCGGAACAGTACGCCAAGGAAAACGGTACCAAGCTGCTGCTGACCAACGACCC TCTGGAAGCGGCCCACGGAGGAAATGTGCTGATTACCGACACCTGGATTTCGAT GGGCCAGGAGGAGGAGAAGAAGAAGAGACTGCAGGCGTTCCAGGGATATCAG GTCACCATGAAAACCGCCAAGGTCGCCGCCAGCGACTGGACCTTCCTGCACTGT CTCCCTCGGAAACCGGAAGAAGTGGATGACGAGGTGTTCTACTCCCCGCGCTCG CTGGTGTTCCCGGAGGCTGAAAACAGGAAGTGGACAATCATGGCCGTGATGGT GTCCCTGTTGACCGACTACTCCCCACAACTGCAGAAGCCCAAGTTCTAG >pARM570 (SEQ ID NO: 135) ATGCTTTTCAATCTGCGCATCCTCCTGAACAACGCCGCCTTCCGCAATGGACAC AACTTTATGGTCCGCAACTTCCGCTGTGGGCAGCCGCTGCAGAACAAGGTCCAG CTCAAGGGGAGAGATCTCCTGACCCTGAAGAACTTCACTGGAGAGGAGATCAA GTACATGCTGTGGCTGTCCGCCGACCTGAAATTTCGGATTAAGCAGAAGGGCGA ATACCTCCCACTGCTGCAAGGAAAGTCTTTGGGCATGATCTTCGAAAAGAGAAG CACCCGGACCCGGTTGAGCACCGAAACTGGGTTCGCGCTCCTCGGTGGACACCC GTGCTTCCTGACCACCCAAGATATTCATCTGGGTGTCAACGAAAGCCTGACCGA CACCGCCAGGGTGCTGTCATCCATGGCTGACGCAGTGCTCGCCCGGGTGTACAA GCAGTCAGACCTGGACACCCTCGCCAAGGAAGCTTCGATCCCTATCATCAACGG ACTTTCCGACCTGTACCACCCCATCCAAATTCTGGCCGACTACCTGACTCTGCA AGAACACTATAGCTCGCTGAAAGGACTTACTCTGTCCTGGATCGGGGACGGCA ACAACATTCTCCATTCCATCATGATGTCCGCTGCCAAGTTCGGAATGCACCTTC AAGCAGCGACTCCCAAGGGATACGAACCTGATGCCTCCGTGACTAAGCTGGCA GAGCAGTACGCCAAGGAGAACGGTACAAAGCTGCTGCTCACGAACGACCCCCT GGAGGCGGCCCACGGCGGAAACGTGCTGATTACCGATACCTGGATCTCAATGG GCCAGGAAGAGGAGAAGAAGAAGCGGCTCCAGGCGTTTCAAGGCTACCAGGTC ACCATGAAAACCGCGAAGGTCGCCGCCTCCGACTGGACTTTCTTGCACTGCCTG CCGCGGAAGCCCGAGGAAGTGGATGACGAAGTGTTCTACTCGCCGAGATCGTT GGTGTTCCCTGAGGCCGAAAACAGGAAGTGGACCATCATGGCCGTGATGGTGT CCCTGCTGACTGATTACAGCCCACAGCTGCAGAAGCCTAAGTTCTAG >pARM571 (SEQ ID NO: 136) ATGCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGATCAA GTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGGGA ATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACCC CTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCGA TACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAACGG CCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTGCAA GAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGCAAC AACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTTCAA GCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGCCGA GCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCACTAG AAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGGGCC AGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGTCAC CATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCTGCC TCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCCTCG TGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGTCA CTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAG >pARM572 (SEQ ID NO: 137) ATGCTTTTCAACCTGAGAATCCTCCTGAACAACGCCGCCTTCCGCAATGGTCAT AACTTCATGGTCCGCAACTTTCGCTGCGGACAGCCTCTCCAAAACAAGGTCCAG CTCAAGGGGCGCGACCTCCTCACACTGAAGAACTTCACTGGAGAAGAAATCAA GTACATGCTGTGGCTGAGCGCCGATCTGAAGTTCCGGATCAAGCAGAAGGGAG AGTACCTTCCTCTGCTGCAAGGGAAGTCCTTGGGAATGATTTTCGAGAAGCGGT CCACCCGGACCAGGCTGAGCACTGAAACTGGCTTCGCCCTGCTGGGAGGCCAC CCTTGTTTCCTGACCACTCAGGACATCCACCTGGGCGTGAACGAGTCCCTGACC GATACTGCCAGAGTGCTGTCCTCCATGGCCGACGCCGTGCTCGCCCGGGTGTAC AAGCAGTCAGACCTCGATACGCTGGCCAAGGAAGCCTCCATTCCCATTATCAAT GGTCTGTCGGACCTCTACCATCCAATCCAAATCCTCGCCGACTACCTGACTCTG CAAGAACACTACAGCTCACTCAAGGGCCTCACCCTCTCCTGGATCGGCGACGGA AACAACATCCTTCACTCGATTATGATGTCGGCCGCGAAGTTCGGGATGCACCTC CAAGCTGCCACTCCAAAAGGCTACGAGCCGGATGCCTCAGTGACTAAGTTGGC GGAACAGTATGCGAAGGAGAACGGTACCAAGCTCCTGCTGACTAACGACCCGC TGGAGGCCGCCCACGGGGGAAACGTGCTCATCACCGATACTTGGATTTCCATGG GACAGGAGGAAGAGAAGAAGAAGCGGTTGCAGGCATTTCAGGGCTACCAGGTC ACCATGAAAACTGCCAAAGTCGCCGCCAGCGACTGGACCTTCCTGCACTGCCTG CCCCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCTCCCCGGTCCCTC GTGTTCCCTGAGGCCGAAAACAGGAAGTGGACCATCATGGCTGTGATGGTGTCC CTCCTGACCGACTACAGCCCTCAGCTCCAAAAACCCAAGTTTTAG >pARM573 (SEQ ID NO: 138) ATGCTTTTCAACCTGAGAATCCTCTTGAACAATGCTGCTTTTCGGAATGGCCAC AACTTTATGGTTCGGAACTTCCGTTGCGGCCAGCCTTTACAAAACAAGGTCCAG CTGAAGGGCCGGGATTTGCTCACACTGAAGAACTTTACTGGGGAGGAGATTAA GTATATGCTGTGGCTGTCCGCTGACCTGAAGTTTAGGATCAAGCAGAAGGGCGA ATATCTGCCGCTGCTGCAAGGGAAAAGTCTGGGCATGATTTTTGAAAAGCGCTC TACCCGGACCAGACTGTCTACGGAAACAGGCTTTGCCCTGCTGGGCGGCCACCC CTGTTTTCTGACAACGCAGGACATCCATCTGGGCGTGAACGAATCACTGACCGA TACTGCTCGGGTACTCAGTTCTATGGCTGACGCAGTGCTGGCTAGGGTGTACAA GCAGAGCGACTTGGACACACTGGCTAAGGAGGCCAGCATCCCCATTATCAATG GCCTGTCTGATTTGTACCATCCCATTCAAATCCTGGCTGATTATCTGACACTACA AGAGCATTACTCAAGTCTGAAGGGTTTGACTCTCTCCTGGATCGGCGACGGCAA CAACATTTTACATTCCATTATGATGAGTGCTGCTAAGTTTGGCATGCATTTGCAA GCTGCTACCCCAAAGGGCTATGAACCTGACGCTAGCGTAACCAAGTTGGCCGA ACAGTATGCTAAAGAGAATGGCACCAAGCTGCTCCTGACGAATGACCCCCTGG AAGCTGCTCATGGCGGAAACGTACTTATAACTGATACATGGATTAGCATGGGCC AGGAAGAGGAGAAGAAGAAGAGACTGCAGGCCTTCCAAGGCTATCAGGTCACC ATGAAAACTGCCAAGGTTGCAGCTAGCGACTGGACCTTCCTGCACTGTTTGCCG AGGAAACCCGAGGAGGTGGACGATGAAGTCTTTTATTCTCCCCGCTCCTTGGTG TTTCCCGAGGCTGAAAATCGAAAGTGGACGATAATGGCAGTGATGGTGTCCCTA CTGACCGACTATTCTCCACAACTGCAGAAGCCTAAATTCTAG >pARM574 (SEQ ID NO: 139) ATGCTTTTCAATCTGAGGATCCTGCTGAACAACGCTGCTTTTCGCAACGGTCAT AACTTTATGGTTCGCAATTTTCGTTGTGGCCAGCCGCTGCAGAACAAGGTTCAG CTGAAGGGCAGAGATCTGCTGACTCTGAAGAACTTCACTGGGGAAGAAATCAA GTATATGTTATGGCTGTCCGCGGATCTGAAATTTCGAATCAAGCAGAAGGGCGA ATATCTTCCCCTGCTGCAAGGGAAATCCTTGGGCATGATTTTTGAGAAGAGGAG CACTAGGACTAGATTGTCAACAGAAACAGGCTTTGCTTTGTTGGGCGGACATCC CTGCTTTCTGACGACACAGGATATCCACCTCGGCGTAAACGAGTCCCTCACCGA CACTGCTAGGGTACTGAGCAGCATGGCCGACGCTGTGCTAGCCCGGGTTTACAA GCAGTCAGACCTGGACACCCTTGCCAAGGAAGCTTCTATTCCAATTATCAACGG CCTGAGTGACCTGTATCACCCTATTCAAATACTCGCCGACTATTTGACGCTTCAA GAACATTACAGCAGCCTCAAGGGCTTAACCTTGAGTTGGATAGGCGACGGCAA CAATATCCTGCATTCCATTATGATGTCTGCCGCTAAGTTTGGCATGCATCTACAA GCCGCAACACCCAAGGGCTATGAACCCGACGCTAGCGTGACCAAGCTGGCCGA GCAGTATGCTAAGGAAAATGGCACAAAGCTCCTTCTTACCAACGATCCCCTGGA GGCTGCTCACGGCGGCAACGTGCTGATTACCGATACATGGATTAGCATGGGCCA GGAGGAGGAGAAAAAGAAGCGGCTCCAGGCTTTTCAAGGCTATCAGGTCACCA TGAAAACTGCAAAGGTCGCTGCCTCCGACTGGACTTTCCTGCATTGTCTACCCC GCAAGCCTGAGGAAGTGGACGATGAGGTGTTCTACTCCCCACGGAGTCTGGTGT TCCCGGAAGCAGAGAATCGGAAGTGGACCATCATGGCTGTCATGGTGTCGCTCT TGACTGACTATTCTCCCCAACTGCAAAAACCCAAGTTTTAG >pARM575 (SEQ ID NO: 140) ATGCTTTTCAATCTGAGGATCCTGCTGAACAACGCTGCTTTTCGCAACGGTCAT AACTTTATGGTTCGCAATTTTCGTTGTGGCCAGCCGCTGCAGAACAAGGTTCAG CTGAAGGGCAGAGATCTGCTGACTCTGAAGAACTTCACTGGGGAAGAAATCAA GTATATGTTATGGCTGTCCGCGGATCTGAAATTTCGAATCAAGCAGAAGGGCGA ATATCTTCCCCTGCTGCAAGGGAAATCCTTGGGCATGATTTTTGAGAAGAGGAG CACTAGGACTAGATTGTCAACAGAAACAGGCTTTGCTTTGTTGGGCGGACATCC CTGCTTTCTGACGACACAGGATATCCACCTCGGCGTAAACGAGTCCCTCACCGA CACTGCTAGGGTACTGAGCAGCATGGCCGACGCTGTGCTAGCCCGGGTTTACAA GCAGTCAGACCTGGACACCCTTGCCAAGGAAGCTTCTATTCCAATTATCAACGG CCTGAGTGACCTGTATCACCCTATTCAAATACTCGCCGACTATTTGACGCTTCAA GAACATTACAGCAGCCTCAAGGGCTTAACCTTGAGTTGGATAGGCGACGGCAA CAATATCCTGCATTCCATTATGATGTCTGCCGCTAAGTTTGGCATGCATCTACAA GCCGCAACACCCAAGGGCTATGAACCCGACGCTAGCGTGACCAAGCTGGCCGA GCAGTATGCTAAGGAAAATGGCACAAAGCTCCTTCTTACCAACGATCCCCTGGA GGCTGCTCACGGCGGCAACGTGCTGATTACCGATACATGGATTAGCATGGGCCA GGAGGAGGAGAAAAAGAAGCGGCTCCAGGCTTTTCAAGGCTATCAGGTCACCA TGAAAACTGCAAAGGTCGCTGCCTCCGACTGGACTTTCCTGCATTGTCTACCCC GCAAGCCTGAGGAAGTGGACGATGAGGTGTTCTACTCCCCACGGAGTCTGGTGT TCCCGGAAGCAGAGAATCGGAAGTGGACCATCATGGCTGTCATGGTGTCGCTCT TGACTGACTATTCTCCCCAACTGCAAAAACCCAAGTTTTAG >pARM708 (SEQ ID NO: 141) ATGCTTTTTAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGATCAA GTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGGGA ATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACCC CTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCGA TACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCCATCATCAACGG CCTGAGCGACCTGTACCACCCAATCCAAATCCTGGCTGACTACCTGACCCTGCA AGAGCACTACAGCAGCCTGAAGGGTCTGACCCTGTCATGGATTGGCGATGGAA ACAATATTCTGCACTCCATCATGATGTCCGCCGCGAAGTTCGGAATGCATCTGC AAGCCGCCACGCCAAAAGGATACGAACCGGATGCGTCCGTGACGAAGTTGGCG GAACAGTACGCGAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCCCT CGAGGCTGCGCATGGGGGCAACGTGCTGATTACCGACACCTGGATCTCCATGG GGCAGGAGGAAGAGAAGAAGAAGAGACTGCAGGCATTCCAGGGGTACCAGGT CACCATGAAAACCGCAAAAGTGGCAGCTTCGGACTGGACTTTCCTGCATTGCCT GCCGAGGAAGCCGGAGGAAGTCGACGACGAAGTGTTCTACTCGCCTCGGTCCC TGGTGTTCCCCGAGGCCGAAAACCGGAAGTGGACCATCATGGCCGTGATGGTG TCCTTGCTGACTGACTATAGCCCGCAGCTGCAGAAGCCTAAGTTCTAG >pARM709 (SEQ ID NO: 142) ATGCTTTTCAACCTGAGAATCCTCTTGAACAATGCTGCTTTTCGGAATGGCCAC AACTTTATGGTTCGGAACTTCCGTTGCGGCCAGCCTTTACAAAACAAGGTCCAG CTGAAGGGCCGGGATTTGCTCACACTGAAGAACTTTACTGGAGAAGAGATCAA GTACATGCTGTGGCTGTCGGCCGACCTGAAGTTCAGGATCAAGCAGAAGGGAG AATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCT CAACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACC CCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCG ATACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACA AACAGTCCGATCTCGATACCTTGGCAAAGGAGGCTTCCATTCCCATCATCAACG GCCTGAGCGACCTGTACCACCCAATCCAAATCCTGGCTGACTACCTGACCCTGC AAGAGCACTACAGCAGCCTGAAGGGTCTGACCCTGTCATGGATTGGCGATGGA AACAATATTCTGCACTCCATCATGATGTCCGCCGCGAAGTTCGGAATGCATCTG CAAGCCGCCACTCCAAAAGGATACGAACCGGATGCGTCCGTGACCAAGTTGGC GGAACAGTACGCGAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCCC TCGAGGCTGCGCATGGGGGCAACGTGCTGATTACCGACACCTGGATCTCCATGG GGCAGGAGGAAGAGAAGAAGAAGAGACTGCAGGCATTCCAGGGGTACCAGGT CACCATGAAAACCGCAAAAGTGGCAGCTTCGGACTGGACTTTCCTGCATTGCCT GCCGAGGAAGCCGGAGGAAGTCGACGACGAAGTGTTCTACTCGCCTCGGTCCC TGGTGTTCCCCGAGGCCGAAAACCGGAAGTGGACCATCATGGCCGTGATGGTG TCCTTGCTGACTGACTATAGCCCGCAGCTGCAGAAGCCTAAGTTCTAG >pARM710 (SEQ ID NO: 143) ATGCTTTTCAACCTGAGAATCCTCTTGAACAATGCTGCTTTTCGGAATGGCCAC AACTTTATGGTTCGGAACTTCCGTTGCGGCCAGCCTTTACAAAACAAGGTCCAG CTGAAGGGCCGGGATTTGCTCACACTAAAGAACTTTACTGGAGAAGAGATCAA GTACATGCTATGGCTGTCGGCCGACCTGAAGTTCCGTATCAAGCAGAAGGGAG AATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCT CAACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACC CCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCG ATACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACA AACAGTCCGATCTCGATACCTTGGCAAAGGAGGCTTCCATTCCCATCATCAACG GCCTGAGCGACCTGTACCACCCAATCCAAATCCTGGCTGACTACCTGACCCTGC AAGAGCACTACAGCAGCCTGAAGGGTCTGACCCTGTCATGGATTGGCGATGGA AACAATATTCTGCACTCCATCATGATGTCCGCCGCGAAGTTCGGAATGCATCTG CAAGCCGCCACTCCAAAAGGATACGAACCGGATGCATCCGTGACCAAGTTGGC GGAACAGTACGCGAAGGAGAACGGAACCAAGCTCCTGCTGACTAACGACCCGC TCGAGGCTGCGCATGGGGGTAACGTGCTGATTACGGACACCTGGATCTCCATGG GGCAGGAGGAAGAGAAGAAGAAGAGACTGCAGGCATTCCAGGGGTACCAGGT CACCATGAAAACCGCAAAAGTGGCAGCTTCGGACTGGACTTTCCTGCATTGCCT GCCGAGGAAGCCGGAGGAAGTCGACGACGAAGTGTTCTACTCGCCTCGGTCCC TGGTGTTCCCCGAGGCCGAAAACCGGAAGTGGACCATCATGGCCGTGATGGTG TCCTTGCTGACTGACTATAGCCCGCAGCTGCAGAAGCCTAAGTTCTAG >pARM711 (SEQ ID NO: 144) ATGCTTTTCAACCTGAGAATCCTCTTGAACAATGCTGCTTTTCGGAATGGCCAC AACTTTATGGTTCGGAACTTCCGTTGCGGCCAGCCTTTACAAAACAAGGTCCAG CTGAAGGGCCGGGATTTGCTCACACTAAAGAACTTTACTGGAGAAGAGATCAA GTACATGCTATGGCTGTCGGCCGACCTGAAGTTCCGTATCAAGCAGAAGGGAG AATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCT CAACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACC CCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCG ATACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACA AACAGTCCGATCTCGATACCTTGGCAAAGGAGGCTTCCATTCCCATCATCAACG GCCTGAGCGACCTGTACCACCCAATCCAAATCCTGGCTGACTACCTGACCCTGC AAGAGCACTACAGCAGCCTGAAGGGTCTGACCCTGTCATGGATTGGCGATGGA AACAATATTCTGCACTCCATCATGATGTCCGCCGCGAAGTTCGGAATGCATCTG CAAGCCGCCACTCCAAAAGGATACGAACCGGATGCGTCCGTGACCAAGTTGGC GGAACAGTACGCGAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCCC TCGAGGCTGCGCATGGGGGCAACGTGCTGATTACCGACACCTGGATCTCCATGG GGCAGGAGGAAGAGAAGAAGAAGAGACTGCAGGCATTCCAGGGGTACCAGGT CACCATGAAAACCGCAAAAGTGGCAGCTTCGGACTGGACTTTCCTGCATTGCCT GCCGAGGAAGCCGGAGGAAGTCGACGACGAAGTGTTCTACTCGCCTCGGTCCC TGGTGTTCCCCGAGGCCGAAAACCGGAAGTGGACCATCATGGCCGTGATGGTG TCCTTGCTGACTGACTATAGCCCGCAGCTGCAGAAGCCTAAGTTCTAG >pARM712 (SEQ ID NO: 145) ATGCTGTTCAACCTGCGAATCCTGCTGAACAACGCCGCTTTTCGGAACGGGCAC AACTTTATGGTGAGGAACTTTCGCTGCGGACAGCCCCTCCAGAATAAGGTCCAG CTGAAGGGCAGGGACCTGCTGACCCTGAAAAATTTCACAGGGGAGGAAATCAA GTATATGCTGTGGCTGTCAGCTGATCTGAAGTTCCGGATCAAGCAGAAGGGCGA ATATCTGCCTCTGCTCCAGGGCAAAAGCCTGGGGATGATCTTCGAAAAGCGCAG TACTCGGACCAGACTGTCAACCGAGACTGGATTCGCTCTGCTGGGAGGACACCC TTGTTTTCTGACCACTCAGGACATTCACCTGGGAGTGAACGAGTCCCTGACCGA CACTGCTCGCGTCCTGAGCTCTATGGCCGACGCTGTGCTGGCTCGAGTCTACAA ACAGTCCGACCTGGATACCCTGGCCAAGGAAGCTTCTATCCCAATTATTAACGG CCTGTCAGACCTGTATCACCCCATCCAGATTCTGGCCGATTACCTGACCCTCCA GGAGCACTATTCTAGTCTGAAAGGGCTGACACTGAGTTGGATTGGGGACGGAA ACAATATCCTGCACTCTATTATGATGTCAGCCGCCAAGTTTGGAATGCACCTCC AGGCTGCAACCCCAAAAGGCTACGAACCCGATGCCTCAGTGACAAAGCTGGCT GAACAGTACGCCAAAGAGAACGGCACTAAGCTGCTGCTGACCAACGACCCTCT GGAGGCCGCTCACGGAGGCAACGTGCTGATCACCGATACCTGGATTAGTATGG GACAGGAGGAAGAGAAGAAGAAGCGGCTCCAGGCCTTCCAGGGCTACCAGGT GACAATGAAAACCGCTAAGGTCGCAGCCAGCGATTGGACCTTTCTGCACTGCCT GCCCAGAAAGCCCGAAGAGGTGGACGACGAGGTCTTCTACTCTCCCAGAAGCC TGGTGTTTCCCGAAGCTGAGAATAGGAAGTGGACAATTATGGCAGTGATGGTC AGCCTGCTGACTGATTATTCACCTCAGCTCCAGAAACCAAAGTTCTGA >pARM713 (SEQ ID NO: 146) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCCTGGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA >pARM714 (SEQ ID NO: 147) ATGCTGTTCAACCTGCGAATCCTGCTGAACAACGCCGCTTTTCGGAACGGGCAC AACTTTATGGTGAGGAACTTTCGCTGCGGACAGCCCCTCCAGAATAAGGTCCAG CTGAAGGGCAGGGACCTGCTGACCCTGAAAAATTTCACAGGGGAGGAAATCAA GTATATGCTGTGGCTGTCAGCTGATCTGAAGTTCCGGATCAAGCAGAAGGGCGA ATATCTGCCTCTGCTCCAGGGCAAAAGCCTGGGGATGATCTTCGAAAAGCGCAG TACTCGGACCAGACTGTCAACCGAGACTGGATTCGCTCTGCTGGGAGGACACCC TTGTTTTCTGACCACTCAGGACATTCACCTGGGAGTGAACGAGTCCCTGACCGA CACTGCTCGCGTCCTGAGCTCTATGGCCGACGCTGTGCTAGCTCGAGTCTACAA ACAGTCCGACCTGGATACCCTGGCCAAGGAAGCTTCTATCCCAATTATTAACGG CCTGTCAGACCTGTATCACCCCATCCAGATTCTGGCCGATTACCTGACCCTCCA GGAGCACTATTCTAGTCTGAAAGGGCTGACACTGAGTTGGATTGGGGACGGAA ACAATATCCTGCACTCTATTATGATGTCAGCCGCCAAGTTTGGAATGCACCTCC AGGCTGCAACCCCAAAAGGCTACGAACCCGATGCCTCAGTGACAAAGCTGGCT GAACAGTACGCCAAAGAGAACGGCACTAAGCTGCTGCTGACCAACGACCCTCT GGAGGCCGCTCACGGAGGCAACGTGCTGATCACCGATACCTGGATTAGTATGG GACAGGAGGAAGAGAAGAAGAAGCGGCTCCAGGCCTTCCAGGGCTACCAGGT GACAATGAAAACCGCTAAGGTCGCAGCCAGCGATTGGACCTTTCTGCACTGCCT GCCCAGAAAGCCCGAAGAGGTGGACGACGAGGTCTTCTACTCTCCCAGAAGCC TGGTGTTTCCCGAAGCTGAGAATAGGAAGTGGACAATTATGGCAGTGATGGTC AGCCTGCTGACTGATTATTCACCTCAGCTCCAGAAACCAAAGTTCTGA >pARM715 (SEQ ID NO: 148) ATGCTGTTCAACCTGCGAATCCTGCTGAACAATGCCGCTTTTCGGAACGGGCAC AATTTCATGGTGAGGAACTTTCGCTGCGGACAGCCCCTCCAGAACAAGGTCCAG CTGAAGGGCAGGGACCTGCTGACCCTGAAAAATTTCACAGGGGAGGAAATCAA GTACATGCTGTGGCTGTCAGCCGATCTGAAGTTCCGGATCAAGCAGAAGGGCG AATATCTGCCTCTGCTCCAGGGCAAAAGCCTGGGGATGATCTTCGAAAAGCGCA GTACTCGGACCAGACTGTCAACAGAGACTGGATTCGCACTGCTGGGAGGACAC CCATGTTTTCTGACCACACAGGACATTCATCTGGGAGTGAACGAGTCCCTGACC GACACAGCACGCGTCCTGAGCTCCATGGCTGATGCAGTGCTGGCTCGAGTCTAC AAACAGTCTGACCTGGATACCCTGGCCAAGGAAGCTTCTATCCCAATCATTAAT GGCCTGAGTGACCTGTATCACCCCATCCAGATTCTGGCCGATTACCTGACCCTC CAGGAGCATTATTCTAGTCTGAAAGGGCTGACACTGAGCTGGATTGGGGACGG AAACAATATCCTGCACTCCATTATGATGAGCGCCGCCAAGTTTGGAATGCACCT CCAGGCTGCAACCCCAAAAGGCTACGAACCCGATGCCTCCGTGACAAAGCTGG CAGAACAGTATGCCAAAGAGAACGGCACTAAGCTGCTGCTGACCAATGACCCT CTGGAGGCCGCTCACGGAGGCAACGTGCTGATCACTGATACCTGGATTAGTATG GGACAGGAGGAAGAGAAGAAGAAGCGGCTCCAGGCCTTCCAGGGCTACCAGG TGACAATGAAAACTGCTAAGGTCGCAGCCAGCGACTGGACCTTTCTGCATTGCC TGCCCAGAAAGCCTGAAGAGGTGGACGATGAGGTCTTCTACTCACCCAGAAGC CTGGTGTTTCCTGAAGCTGAGAATAGGAAGTGGACAATCATGGCAGTGATGGTC AGCCTGCTGACTGATTATTCCCCTCAGCTCCAGAAACCAAAGTTCTGA >pARM716 (SEQ ID NO: 149) ATGCTTTTCAACCTTCGCATTCTCCTCAACAACGCCGCGTTTAGAAACGGACAC AACTTCATGGTCCGCAACTTCCGCTGCGGACAGCCGCTGCAGAACAAGGTCCAG CTCAAGGGTCGGGATCTCCTGACGCTGAAGAACTTTACCGGCGAAGAGATTAA GTACATGCTGTGGCTGTCCGCCGACCTTAAGTTCCGGATCAAGCAGAAGGGCGA ATACCTTCCCCTGCTGCAAGGAAAGTCCCTGGGCATGATCTTCGAGAAGCGCAG TACCAGAACCAGACTCTCCACTGAAACCGGGTTCGCGCTGCTTGGCGGCCACCC GTGTTTCCTCACTACGCAAGACATCCATCTTGGCGTGAACGAGTCCCTTACCGA CACCGCCAGGGTGCTGTCAAGCATGGCCGACGCCGTCCTTGCGCGCGTGTACAA GCAGTCAGACCTTGATACTCTGGCCAAGGAAGCCTCCATCCCTATTATCAACGG CCTATCCGACCTTTACCACCCGATCCAGATCCTCGCTGACTACCTGACCCTGCA AGAACACTACAGCAGCCTCAAGGGACTGACTCTGTCCTGGATCGGCGACGGGA ACAACATCCTGCACTCAATCATGATGAGCGCAGCCAAGTTCGGCATGCATCTCC AAGCCGCTACACCCAAGGGTTATGAACCGGACGCCTCTGTGACCAAGTTGGCA GAACAGTACGCCAAGGAGAACGGTACTAAGCTCCTTTTAACCAACGACCCCCTC GAAGCAGCCCATGGCGGGAATGTGCTCATTACCGATACCTGGATTTCGATGGGC CAGGAGGAGGAGAAGAAGAAGCGGCTGCAGGCGTTCCAGGGCTACCAGGTCA CCATGAAAACTGCCAAAGTGGCCGCCTCGGATTGGACCTTTCTCCACTGCCTGC CTCGGAAGCCTGAGGAGGTGGACGACGAAGTGTTCTACTCCCCACGGTCCCTCG TGTTCCCCGAGGCCGAAAATAGGAAGTGGACCATCATGGCCGTGATGGTGTCCC TCTTGACCGATTACAGCCCGCAGCTTCAGAAGCCTAAATTCTAG >pARM717 (SEQ ID NO: 150) ATGCTTTTCAATCTTCGCATCCTGTTGAACAACGCCGCCTTCCGCAATGGTCACA ACTTCATGGTCCGGAACTTCAGATGTGGACAGCCTCTCCAAAACAAGGTCCAGC TGAAGGGAAGGGACCTCTTAACCCTCAAAAACTTTACTGGAGAGGAGATCAAG TACATGCTGTGGCTTAGCGCCGACCTTAAGTTCCGGATCAAGCAGAAGGGAGA GTACCTCCCGCTGCTGCAAGGAAAGAGTCTTGGAATGATCTTCGAGAAGCGGTC CACCAGAACTCGCCTCTCCACTGAAACCGGATTCGCACTCCTGGGTGGACACCC GTGCTTTCTGACCACCCAAGACATCCACCTCGGAGTGAACGAGAGCCTCACGGA CACCGCGAGAGTGCTGTCATCCATGGCCGACGCCGTGCTTGCACGGGTCTACAA GCAGTCCGATCTGGACACTCTTGCCAAGGAAGCCTCCATTCCTATCATTAACGG TCTGTCGGATCTGTACCACCCGATTCAGATCCTTGCGGACTACCTCACACTTCAA GAACACTATTCAAGCCTAAAGGGTCTGACCCTGTCCTGGATCGGAGATGGAAA CAACATTCTCCATTCCATCATGATGAGCGCTGCCAAGTTCGGAATGCATCTCCA AGCAGCGACTCCTAAGGGTTACGAGCCGGACGCCTCAGTGACTAAGCTGGCCG AGCAGTACGCCAAGGAGAACGGTACCAAACTGTTGCTTACTAACGACCCGCTT GAAGCGGCCCATGGAGGAAACGTGCTGATTACCGACACCTGGATTTCGATGGG ACAGGAAGAGGAGAAGAAGAAGCGGCTCCAGGCGTTCCAGGGATACCAGGTC ACCATGAAAACGGCCAAAGTGGCCGCTAGCGATTGGACCTTTCTGCACTGCCTC CCGCGCAAGCCTGAAGAAGTGGACGACGAAGTGTTCTACTCCCCTCGCTCTCTT GTGTTCCCGGAAGCCGAAAACAGGAAGTGGACCATCATGGCCGTGATGGTGTC CCTCCTGACCGATTACAGCCCGCAGCTGCAGAAGCCTAAGTTCTAG >pARM718 (SEQ ID NO: 151) ATGCTTTTCAATCTCCGCATCCTCCTCAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAGAACAAGGTCCAG CTCAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAAATCAA GTACATGCTCTGGCTCTCCGCCGACTTGAAGTTCCGCATTAAGCAGAAGGGGGA ATACCTTCCGCTGCTGCAAGGAAAGTCGCTCGGCATGATCTTTGAGAAGCGCTC AACCCGCACCAGGCTGTCCACTGAAACCGGGTTCGCGCTGCTTGGTGGCCACCC CTGCTTCCTGACCACCCAAGACATTCACCTCGGAGTGAACGAATCGCTCACTGA TACTGCCCGGGTGCTGTCGTCGATGGCCGATGCAGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCCATCCCTATTATCAACGG CCTTTCCGACCTCTACCACCCGATTCAGATCCTTGCCGATTACCTCACCCTGCAA GAACACTACTCGTCACTGAAGGGTCTGACCTTGTCCTGGATCGGCGACGGCAAC AACATCCTCCATTCCATTATGATGTCCGCCGCCAAATTCGGCATGCATCTTCAA GCCGCAACCCCTAAGGGTTACGAGCCGGACGCTTCCGTGACCAAGCTCGCCGA GCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCCCTAG AGGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGGGAC AGGAAGAAGAGAAGAAGAAGCGGTTACAGGCGTTCCAGGGCTATCAGGTCACC ATGAAAACCGCCAAGGTCGCTGCCTCGGACTGGACCTTCCTGCATTGCCTGCCT CGCAAGCCCGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGTCCCTTGTG TTCCCTGAGGCCGAGAATAGAAAGTGGACCATTATGGCCGTGATGGTGTCCCTT CTCACCGACTACTCGCCGCAACTGCAGAAACCCAAGTTCTAG >pARM719 (SEQ ID NO: 152) ATGCTTTTCAATCTTCGCATCCTCCTCAACAACGCCGCCTTCCGGAACGGTCACA ACTTCATGGTCCGGAACTTCCGCTGCGGCCAGCCGCTCCAAAACAAAGTGCAGC TTAAGGGCCGCGATCTCCTGACCCTGAAGAACTTCACCGGAGAGGAAATCAAG TACATGCTGTGGCTCTCGGCGGACCTGAAGTTTAGGATTAAGCAGAAGGGGGA GTATCTGCCGCTGCTCCAAGGGAAGTCCCTTGGCATGATCTTCGAAAAGAGGTC CACCCGGACTCGGCTCAGCACCGAAACAGGTTTTGCACTTCTGGGGGGCCACCC GTGCTTCCTGACGACCCAGGACATCCATCTGGGTGTCAACGAGAGTTTGACCGA CACTGCCAGAGTGCTGTCATCCATGGCGGACGCGGTGCTCGCGAGAGTGTACA AGCAGTCCGATCTTGACACCCTGGCAAAAGAGGCTTCAATCCCGATCATTAACG GACTCTCGGATCTGTACCACCCTATCCAAATCTTGGCCGACTACCTGACCCTGC AAGAACACTACAGCTCCCTGAAGGGCCTGACTCTTTCCTGGATTGGCGATGGAA ACAACATTCTCCATTCTATTATGATGTCCGCCGCCAAGTTCGGCATGCACCTTCA AGCCGCCACCCCGAAGGGCTACGAACCTGACGCCTCCGTGACTAAGCTAGCCG AACAGTACGCTAAGGAGAACGGCACTAAGCTTCTCCTTACCAACGATCCGCTGG AGGCGGCCCATGGCGGAAATGTGCTTATCACCGACACCTGGATTAGCATGGGG CAGGAAGAAGAGAAGAAGAAACGGCTCCAGGCATTCCAGGGCTACCAGGTCAC CATGAAAACTGCCAAGGTCGCCGCTAGCGACTGGACCTTCCTCCACTGTCTGCC TCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCCCCGCGCTCCCTCGT GTTTCCTGAGGCCGAGAACAGAAAGTGGACCATCATGGCCGTGATGGTGTCATT ACTTACGGACTACAGCCCGCAGCTGCAGAAGCCGAAGTTCTAG >pARM720 (SEQ ID NO: 153) ATGCTTTTTAACTTGAGAATCCTTCTGAACAACGCCGCTTTCCGCAACGGTCATA ACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCCCTCCAAAACAAAGTGCAGC TGAAGGGCCGGGACCTTCTTACGCTGAAGAATTTCACCGGCGAAGAAATCAAG TACATGCTCTGGCTGTCCGCCGATCTTAAGTTCCGCATTAAGCAGAAGGGGGAA TACCTCCCGCTGCTGCAAGGGAAGTCGCTGGGCATGATTTTTGAGAAGCGGTCA ACTCGCACCCGCCTGTCCACTGAAACTGGATTCGCACTGCTCGGTGGCCATCCC TGCTTCCTGACCACCCAAGACATCCACCTCGGCGTGAACGAGTCCCTGACTGAC ACCGCCCGGGTCTTATCCTCGATGGCCGATGCTGTGCTTGCGAGGGTGTACAAG CAGTCCGACCTCGACACACTCGCGAAGGAGGCCTCCATCCCCATCATCAACGGC CTGTCCGACCTTTACCACCCAATTCAGATCCTCGCCGATTACCTGACCCTGCAA GAGCACTACTCGTCGCTCAAGGGGCTTACCCTCTCGTGGATTGGCGACGGCAAC AACATCCTTCACTCCATCATGATGTCGGCAGCGAAGTTCGGCATGCATCTGCAA GCCGCCACGCCTAAGGGTTATGAACCGGATGCCTCAGTGACCAAGCTCGCCGA ACAGTACGCGAAAGAGAATGGAACCAAGCTACTTCTGACCAACGACCCCCTGG AGGCCGCTCACGGCGGCAACGTCCTCATTACCGATACTTGGATTTCGATGGGAC AGGAAGAGGAAAAGAAGAAGAGACTGCAGGCGTTCCAGGGATACCAGGTCAC CATGAAAACTGCCAAAGTGGCAGCCTCCGACTGGACCTTCCTTCACTGCCTGCC GAGGAAGCCTGAAGAGGTGGACGACGAGGTGTTCTACTCCCCGCGCTCCTTGGT GTTTCCTGAGGCCGAAAACCGGAAGTGGACTATCATGGCCGTGATGGTGTCCCT CCTCACCGACTACTCGCCGCAACTGCAGAAGCCTAAGTTCTAG >pARM721 (SEQ ID NO: 154) ATGTTATTCAACCTTAGAATTCTCCTTAACAACGCCGCCTTCCGGAATGGGCAT AACTTTATGGTCCGCAATTTCCGCTGTGGACAGCCTCTGCAAAACAAGGTCCAG CTCAAGGGCCGGGATCTGCTGACTCTCAAGAACTTCACTGGGGAAGAAATCAA GTACATGCTCTGGCTGAGCGCCGACCTCAAGTTCCGCATCAAGCAGAAGGGAG AGTACCTCCCGCTGCTCCAAGGGAAGTCCCTGGGCATGATCTTCGAGAAGAGAT CCACCCGCACCAGACTTTCCACTGAGACTGGCTTCGCCTTGCTGGGAGGCCACC CATGCTTCCTGACGACCCAGGACATTCACCTTGGCGTGAACGAGTCCCTGACTG ACACCGCAAGGGTGTTGTCCTCGATGGCCGACGCCGTGCTTGCCCGGGTGTACA AGCAGAGCGATCTTGACACCCTGGCTAAGGAAGCTTCCATTCCCATCATCAACG GTCTGAGCGACCTGTACCACCCGATTCAGATCCTGGCGGACTACCTAACCCTGC AAGAGCACTATAGCTCCCTGAAGGGCCTCACACTTTCATGGATCGGCGACGGCA ACAACATCCTGCACTCTATTATGATGAGCGCTGCCAAATTCGGCATGCACCTCC AAGCCGCCACGCCTAAAGGCTACGAGCCCGACGCCTCGGTGACCAAGCTTGCG GAGCAGTACGCGAAGGAAAACGGCACCAAGCTGCTTCTCACCAACGATCCTCT GGAAGCGGCCCATGGTGGCAACGTGCTCATTACCGACACTTGGATCTCCATGGG ACAGGAGGAGGAAAAGAAGAAGCGGCTCCAGGCGTTTCAGGGTTACCAGGTCA CCATGAAAACCGCCAAGGTCGCAGCCTCCGACTGGACCTTCCTTCATTGCCTTC CGCGCAAGCCCGAAGAAGTGGACGATGAAGTGTTTTACTCACCTCGGTCACTCG TGTTCCCGGAAGCAGAGAACAGGAAATGGACCATTATGGCCGTGATGGTGTCC CTGCTCACCGATTACAGTCCGCAACTGCAGAAGCCCAAGTTCTAG >pARM722 (SEQ ID NO: 155) ATGCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGATCAA GTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGGGA ATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACCC CTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCGA TACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAACGG CCTTAGTGACCTCTACCATCCGATTCAAATCCTGGCCGATTACCTCACCCTGCAA GAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGCAAC AACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTTCAA GCCGCCACGCCTAAGGGTTACGAACCCGACGCTTCCGTGACTAAGCTCGCCGAG CAGTACGCTAAGGAGAACGGAACCAAGCTGCTGCTGACTAACGACCCGCTAGA AGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGGGCCA GGAGGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGTCACC ATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCTGCCT CGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCCTCGT GTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGTCAC TTCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAG >pARM723 (SEQ ID NO: 156) ATGCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAGGTCCAG CTTAAGGGCCGGGATCTCCTCACCCTTAAAAACTTCACCGGCGAAGAGATCAAG TACATGCTCTGGCTCTCCGCGGACCTTAAGTTCCGCATTAAGCAGAAGGGGGAA TACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCTCA ACCAGGACCAGGCTTTCTACTGAAACTGGGTTCGCGCTTCTCGGCGGTCATCCC TGCTTCCTCACGACCCAAGACATCCACCTCGGAGTGAACGAATCCCTCACGGAT ACTGCCCGCGTGCTTTCGAGCATGGCAGACGCCGTGCTCGCCCGGGTGTACAAA CAGTCCGATCTCGACACTCTCGCCAAGGAGGCGTCAATTCCTATTATCAACGGT CTTAGTGACCTTTACCACCCGATCCAGATCCTCGCCGATTACCTCACACTCCAA GAACACTACAGCTCCCTTAAGGGTCTTACCCTCTCCTGGATCGGCGACGGCAAC AACATTCTCCACTCCATCATGATGTCCGCCGCAAAGTTCGGCATGCATCTTCAA GCCGCCACCCCGAAGGGCTACGAGCCTGATGCTTCCGTGACTAAGCTCGCCGAG CAGTACGCTAAGGAGAACGGAACCAAGCTTCTTCTCACTAACGACCCACTCGA AGCAGCCCATGGGGGCAACGTGCTTATCACTGACACCTGGATCTCCATGGGCCA GGAAGAAGAGAAGAAGAAGCGGCTCCAGGCGTTCCAGGGATATCAGGTCACCA TGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTTCTCCACTGCCTCCCTC GCAAACCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCCCGGAGCCTCGTG TTCCCCGAGGCCGAGAATAGAAAGTGGACCATTATGGCCGTGATGGTGTCACTC CTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAG >pARM724 (SEQ ID NO: 157) ATGCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGACAT AACTTCATGGTCCGGAACTTCAGATGTGGACAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGTCGGGATCTTCTGACCCTGAAGAACTTTACCGGAGAAGAGATCAA GTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGAGA ATACCTCCCGCTGCTTCAAGGAAAGAGCCTCGGAATGATTTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGATTCGCGCTGCTGGGTGGACACCC CTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACTGA TACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATCATCAACGG ACTTAGTGACCTCTACCATCCGATTCAAATCCTGGCCGACTACCTCACCCTGCA AGAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGAGATGGAA ACAACATTCTCCACTCCATCATGATGTCCGCCGCAAAATTCGGAATGCATCTTC AAGCCGCCACGCCTAAGGGTTACGAACCCGACGCTTCCGTGACTAAGCTCGCCG AGCAGTACGCTAAGGAGAACGGTACCAAGCTTCTCCTGACCAACGACCCACTA GAAGCAGCCCACGGTGGAAACGTGCTTATTACTGACACTTGGATCTCCATGGGA CAGGAGGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGTCA CCATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCTGC CTCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCGCGGAGCCTC GTGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGTC ACTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAG >pARM725 (SEQ ID NO: 158) ATGCTTTTCAACCTCCGCATTCTCCTCAACAACGCTGCCTTCCGGAATGGACATA ACTTCATGGTCCGGAACTTCAGATGCGGACAGCCGCTTCAGAACAAGGTCCAGC TTAAGGGGAGAGATCTCCTTACCCTCAAAAACTTCACTGGCGAAGAAATCAAGT ACATGCTCTGGCTTAGTGCGGATCTCAAGTTCCGCATCAAGCAGAAGGGAGAAT ACCTCCCGCTCCTTCAAGGAAAGAGCCTCGGCATGATTTTTGAGAAGAGGTCCA CCAGAACTCGCCTTTCAACCGAGACTGGGTTCGCCCTGCTTGGCGGTCACCCCT GCTTCCTCACTACCCAAGACATCCACCTCGGCGTGAACGAGAGCCTTACCGACA CCGCCCGCGTGCTCTCCTCAATGGCCGACGCTGTGCTCGCCCGGGTGTACAAGC AGTCCGACCTTGATACTCTCGCCAAGGAGGCCTCCATCCCAATTATCAACGGGC TCTCTGATCTCTACCACCCTATCCAAATCCTCGCGGACTACCTCACCCTCCAAGA GCACTATAGCTCGCTCAAGGGCCTCACCCTTTCCTGGATTGGCGACGGCAACAA CATTCTTCACTCGATCATGATGTCCGCCGCCAAGTTCGGCATGCATCTCCAAGC CGCGACCCCCAAGGGCTACGAGCCTGACGCATCCGTGACCAAGCTCGCCGAGC AGTACGCGAAGGAAAATGGCACCAAGCTTCTTCTCACCAACGACCCCCTTGAG GCCGCTCATGGCGGCAACGTGCTCATCACTGACACTTGGATCAGCATGGGCCAG GAGGAGGAAAAGAAGAAGCGCCTTCAGGCATTCCAGGGTTACCAGGTCACCAT GAAAACCGCCAAAGTGGCCGCCTCCGACTGGACCTTTCTTCACTGTCTCCCGCG GAAGCCTGAAGAAGTGGATGACGAAGTGTTTTACTCCCCTCGGTCACTCGTGTT CCCGGAAGCAGAAAACAGGAAGTGGACCATTATGGCGGTCATGGTGTCCCTCC TCACCGACTACAGCCCGCAGCTTCAGAAACCCAAGTTCTAG >pARM726 (SEQ ID NO: 159) ATGCTTTTCAATCTCCGCATCCTCCTTAACAACGCAGCGTTTAGAAACGGTCAC AACTTCATGGTCCGGAACTTCCGCTGTGGACAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGTCGGGACCTTCTGACCCTGAAGAACTTTACTGGAGAAGAGATCAA GTACATGCTTTGGCTGTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGAGA ATACCTTCCGCTGCTCCAAGGAAAGAGCCTGGGAATGATCTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGATTCGCGCTGCTGGGTGGTCACCC TTGCTTCCTGACGACCCAGGACATTCACCTCGGAGTGAACGAGTCCCTCACTGA TACCGCCAGAGTGTTATCGAGCATGGCAGATGCCGTGCTGGCTAGGGTGTACAA ACAGTCCGATCTGGACACCCTGGCCAAGGAGGCATCAATTCCTATTATCAACGG ACTTAGTGACCTCTACCATCCGATTCAAATCCTGGCCGATTACCTCACCCTGCA AGAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGAGATGGAA ACAACATTCTCCATTCCATCATGATGTCCGCGGCCAAGTTCGGAATGCATCTCC AAGCCGCCACGCCGAAAGGATACGAGCCGGACGCTTCCGTGACTAAGCTCGCC GAGCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCGCT AGAAGCCGCCCACGGTGGAAACGTGCTTATTACTGACACCTGGATCTCCATGGG ACAGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGTC ACCATGAAAACCGCCAAGGTCGCCGCCTCCGACTGGACCTTCCTTCACTGCCTG CCTCGGAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCGCGGAGCCT CGTGTTCCCTGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGTC ACTCCTCACCGACTACAGCCCGCAGCTTCAGAAGCCTAAGTTCTAG >pARM727 (SEQ ID NO: 160) ATGCTTTTCAATCTCCGCATTCTCCTCAACAACGCAGCCTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAGAACAAGGTCCAG CTCAAGGGCCGGGACCTCCTCACCCTCAAAAACTTTACCGGCGAAGAGATCAA GTACATGCTCTGGCTTTCGGCCGACCTTAAGTTCCGCATCAAGCAGAAGGGGGA ATACCTTCCGCTGCTTCAAGGAAAGTCCCTCGGCATGATCTTTGAAAAGCGCTC GACCAGGACCCGCCTTTCCACTGAAACCGGGTTCGCGCTTCTCGGTGGCCACCC CTGCTTCCTCACCACCCAAGACATTCACCTCGGAGTGAACGAATCCCTTACCGA TACCGCAAGAGTGCTTTCGTCGATGGCCGATGCCGTGCTTGCGCGGGTGTACAA GCAGTCAGATCTCGACACTCTCGCCAAGGAGGCGTCCATTCCTATTATCAACGG CCTTTCCGACCTTTACCACCCGATTCAGATCCTCGCCGATTACCTCACCCTGCAA GAGCACTACTCGTCACTCAAGGGTCTTACCCTCTCCTGGATCGGCGACGGAAAC AACATCCTCCATTCGATCATGATGTCCGCCGCCAAATTCGGCATGCACCTCCAA GCCGCGACCCCGAAGGGTTACGAGCCCGACGCTTCCGTGACCAAGCTCGCCGA ACAGTACGCTAAGGAAAACGGCACCAAGCTCCTCCTCACTAACGACCCTCTCGA AGCAGCCCATGGGGGCAACGTGCTCATTACTGACACTTGGATCTCGATGGGCCA GGAAGAGGAGAAAAAGAAGCGGCTTCAGGCGTTCCAGGGATATCAGGTCACCA TGAAAACCGCCAAGGTCGCTGCCTCGGACTGGACCTTCCTTCACTGCCTTCCGC GCAAGCCTGAAGAGGTGGACGATGAGGTGTTCTACTCCCCACGGTCCCTTGTGT TCCCCGAGGCCGAGAATAGGAAGTGGACCATCATGGCCGTGATGGTGTCGCTC CTCACTGACTACTCCCCGCAACTTCAGAAGCCTAAGTTCTAG >pARM728 (SEQ ID NO: 161) ATGCTGTTTAATCTGAGAATACTTCTAAACAACGCCGCCTTCCGGAATGGCCAT AACTTTATGGTTCGGAATTTCCGCTGCGGCCAGCCGCTGCAGAACAAGGTCCAG CTGAAGGGAAGAGACTTGCTGACCCTCAAGAACTTCACCGGAGAAGAAATCAA GTATATGCTGTGGCTGTCCGCCGACCTGAAATTCCGCATCAAGCAGAAGGGCGA ATATCTGCCGCTGTTGCAAGGGAAGTCCCTGGGGATGATCTTCGAGAAGAGGTC CACCAGAACACGGCTTTCAACCGAAACCGGGTTTGCACTGCTGGGTGGACACCC CTGTTTTCTGACCACTCAAGATATCCACCTGGGCGTGAACGAGTCCCTTACCGA CACTGCTAGGGTGTTGTCCAGCATGGCCGATGCCGTCCTGGCTCGCGTGTACAA GCAGTCCGACCTGGATACCCTGGCAAAGGAAGCGTCCATTCCCATTATCAACGG GCTGTCCGACCTGTACCATCCGATTCAAATCCTGGCGGACTACCTGACTCTGCA AGAGCATTACAGCAGCTTGAAGGGGCTTACTCTCTCGTGGATCGGCGACGGGA ACAACATCCTGCACTCCATCATGATGTCCGCCGCCAAGTTCGGGATGCATTTGC AAGCTGCGACCCCGAAAGGTTACGAGCCCGATGCTAGCGTAACTAAGCTTGCC GAACAGTACGCCAAAGAGAATGGTACAAAACTGCTTCTGACTAACGACCCGCT GGAAGCAGCCCACGGCGGGAACGTGCTGATAACCGACACCTGGATTTCAATGG GGCAGGAGGAAGAGAAGAAGAAGCGACTGCAGGCGTTCCAAGGCTATCAGGTT ACCATGAAAACCGCCAAAGTGGCAGCCAGCGATTGGACTTTCCTGCACTGTCTG CCGCGGAAGCCCGAGGAAGTTGATGACGAAGTATTCTACTCACCCCGGAGCCT CGTGTTCCCCGAGGCCGAAAACCGGAAGTGGACTATTATGGCCGTGATGGTGTC GCTGTTGACCGACTACAGCCCGCAACTGCAGAAGCCGAAGTTTTAG >pARM729 (SEQ ID NO: 162) ATGCTTTTCAACCTGAGGATCCTTTTGAACAACGCCGCCTTTCGCAACGGCCAC AACTTTATGGTCCGCAATTTCCGCTGCGGGCAGCCGCTGCAGAACAAGGTCCAG CTGAAGGGCCGGGATCTGCTGACCCTGAAGAACTTCACCGGGGAGGAAATCAA GTACATGCTTTGGCTCTCCGCCGATCTGAAGTTCAGAATCAAGCAGAAGGGAGA GTACCTCCCGTTGCTGCAAGGAAAGTCACTCGGAATGATTTTCGAAAAGAGAA GCACTAGGACCCGCCTCTCAACTGAAACCGGGTTCGCGCTGCTCGGGGGCCATC CGTGTTTCCTGACTACCCAAGACATCCACCTGGGAGTGAACGAGTCGCTGACCG ACACCGCACGCGTGCTGTCATCCATGGCGGACGCAGTGCTTGCCCGGGTGTACA AGCAGTCGGACCTGGACACTCTTGCCAAGGAGGCATCAATCCCCATCATTAACG GACTGTCCGATCTCTACCACCCGATTCAGATCCTGGCTGACTACCTAACCCTGC AAGAGCACTACTCAAGCCTGAAGGGGCTGACCCTGTCGTGGATCGGGGACGGC AACAACATTCTGCACTCCATCATGATGTCGGCGGCTAAGTTCGGGATGCATTTG CAAGCGGCAACTCCGAAGGGTTATGAACCCGACGCCTCCGTGACCAAGCTGGC CGAACAGTACGCCAAGGAAAACGGAACCAAGTTGCTGCTGACTAATGATCCCC TGGAGGCGGCCCACGGGGGGAACGTGCTGATAACCGATACCTGGATCTCCATG GGGCAGGAAGAAGAGAAGAAAAAGCGGCTGCAGGCATTCCAGGGATACCAGG TCACCATGAAAACCGCAAAAGTGGCAGCCAGCGACTGGACTTTCCTCCATTGCC TGCCGCGAAAGCCGGAGGAGGTCGATGACGAGGTGTTCTACTCCCCGCGGTCG CTGGTGTTCCCGGAGGCGGAAAACCGGAAGTGGACCATTATGGCCGTGATGGT GTCACTCCTGACTGACTACAGCCCGCAACTGCAGAAGCCGAAGTTCTAG >pARM1787 (SEQ ID NO: 163) ATGCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGATCAA GTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGGGA ATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACCC CTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCGA TACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAACGG CCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTGCAA GAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGCAAC AACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTTCAA GCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGCCGA GCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCACTAG AAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGGGCC AGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGTCAC CATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCTGCC TCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCCTCG TGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGTCA CTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAGATAAGTGAA >pARM1788 (SEQ ID NO: 164) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCCTGGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA ATAAGTGA >pARM1789 (SEQ ID NO: 165) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCCTGGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA ATAAGTGA >pARM1790 (SEQ ID NO: 166) ATGCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGATCAA GTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGGGA ATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACCC CTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCGA TACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAACGG CCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTGCAA GAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGCAAC AACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTTCAA GCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGCCGA GCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCACTAG AAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGGGCC AGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGTCAC CATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCTGCC TCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCCTCG TGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGTCA CTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAGATAAGTGAA >pARM1791 (SEQ ID NO: 167) ATGCTTTTCAACCTGAGAATCCTCTTGAACAATGCTGCTTTTCGGAATGGCCAC AACTTTATGGTTCGGAACTTCCGTTGCGGCCAGCCTTTACAAAACAAGGTCCAG CTGAAGGGCCGGGATTTGCTCACACTAAAGAACTTTACTGGAGAAGAGATCAA GTACATGCTATGGCTGTCGGCCGACCTGAAGTTCCGTATCAAGCAGAAGGGAG AATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCT CAACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACC CCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCG ATACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACA AACAGTCCGATCTCGATACCTTGGCAAAGGAGGCTTCCATTCCCATCATCAACG GCCTGAGCGACCTGTACCACCCAATCCAAATCCTGGCTGACTACCTGACCCTGC AAGAGCACTACAGCAGCCTGAAGGGTCTGACCCTGTCATGGATTGGCGATGGA AACAATATTCTGCACTCCATCATGATGTCCGCCGCGAAGTTCGGAATGCATCTG CAAGCCGCCACTCCAAAAGGATACGAACCGGATGCATCCGTGACCAAGTTGGC GGAACAGTACGCGAAGGAGAACGGAACCAAGCTCCTGCTGACTAACGACCCGC TCGAGGCTGCGCATGGGGGTAACGTGCTGATTACGGACACCTGGATCTCCATGG GGCAGGAGGAAGAGAAGAAGAAGAGACTGCAGGCATTCCAGGGGTACCAGGT CACCATGAAAACCGCAAAAGTGGCAGCTTCGGACTGGACTTTCCTGCATTGCCT GCCGAGGAAGCCGGAGGAAGTCGACGACGAAGTGTTCTACTCGCCTCGGTCCC TGGTGTTCCCCGAGGCCGAAAACCGGAAGTGGACCATCATGGCCGTGATGGTG TCCTTGCTGACTGACTATAGCCCGCAGCTGCAGAAGCCTAAGTTCTAGATAAGT GA >pARM1792 (SEQ ID NO: 168) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCCTGGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA ATAAGTGA >pARM1793 (SEQ ID NO: 169) ATGCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGATCAA GTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGGGA ATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACCC CTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCGA TACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAACGG CCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTGCAA GAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGCAAC AACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTTCAA GCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGCCGA GCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCACTAG AAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGGGCC AGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGTCAC CATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCTGCC TCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCCTCG TGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGTCA CTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAGATAAGTGAA >pARM1794 (SEQ ID NO: 170) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCCTGGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA ATAAGTGA >pARM1795 (SEQ ID NO: 171) ATGCTTTTCAACCTGAGAATCCTCTTGAACAATGCTGCTTTTCGGAATGGCCAC AACTTTATGGTTCGGAACTTCCGTTGCGGCCAGCCTTTACAAAACAAGGTCCAG CTGAAGGGCCGGGATTTGCTCACACTAAAGAACTTTACTGGAGAAGAGATCAA GTACATGCTATGGCTGTCGGCCGACCTGAAGTTCCGTATCAAGCAGAAGGGAG AATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCT CAACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACC CCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCG ATACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACA AACAGTCCGATCTCGATACCTTGGCAAAGGAGGCTTCCATTCCCATCATCAACG GCCTGAGCGACCTGTACCACCCAATCCAAATCCTGGCTGACTACCTGACCCTGC AAGAGCACTACAGCAGCCTGAAGGGTCTGACCCTGTCATGGATTGGCGATGGA AACAATATTCTGCACTCCATCATGATGTCCGCCGCGAAGTTCGGAATGCATCTG CAAGCCGCCACTCCAAAAGGATACGAACCGGATGCATCCGTGACCAAGTTGGC GGAACAGTACGCGAAGGAGAACGGAACCAAGCTCCTGCTGACTAACGACCCGC TCGAGGCTGCGCATGGGGGTAACGTGCTGATTACGGACACCTGGATCTCCATGG GGCAGGAGGAAGAGAAGAAGAAGAGACTGCAGGCATTCCAGGGGTACCAGGT CACCATGAAAACCGCAAAAGTGGCAGCTTCGGACTGGACTTTCCTGCATTGCCT GCCGAGGAAGCCGGAGGAAGTCGACGACGAAGTGTTCTACTCGCCTCGGTCCC TGGTGTTCCCCGAGGCCGAAAACCGGAAGTGGACCATCATGGCCGTGATGGTG TCCTTGCTGACTGACTATAGCCCGCAGCTGCAGAAGCCTAAGTTCTAGATAAGT GA >pARM1796 (SEQ ID NO: 172) ATGCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGATCAA GTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGGGA ATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACCC CTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCGA TACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAACGG CCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTGCAA GAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGCAAC AACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTTCAA GCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGCCGA GCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCACTAG AAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGGGCC AGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGTCAC CATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCTGCC TCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCCTCG TGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGTCA CTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAGATAAGTGAA >pARM1797 (SEQ ID NO: 173) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCCTGGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA ATAAGTGA >pARM1798 (SEQ ID NO: 174) ATGCTTTTCAACCTGAGAATCCTCTTGAACAATGCTGCTTTTCGGAATGGCCAC AACTTTATGGTTCGGAACTTCCGTTGCGGCCAGCCTTTACAAAACAAGGTCCAG CTGAAGGGCCGGGATTTGCTCACACTAAAGAACTTTACTGGAGAAGAGATCAA GTACATGCTATGGCTGTCGGCCGACCTGAAGTTCCGTATCAAGCAGAAGGGAG AATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCT CAACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACC CCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCG ATACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACA AACAGTCCGATCTCGATACCTTGGCAAAGGAGGCTTCCATTCCCATCATCAACG GCCTGAGCGACCTGTACCACCCAATCCAAATCCTGGCTGACTACCTGACCCTGC AAGAGCACTACAGCAGCCTGAAGGGTCTGACCCTGTCATGGATTGGCGATGGA AACAATATTCTGCACTCCATCATGATGTCCGCCGCGAAGTTCGGAATGCATCTG CAAGCCGCCACTCCAAAAGGATACGAACCGGATGCATCCGTGACCAAGTTGGC GGAACAGTACGCGAAGGAGAACGGAACCAAGCTCCTGCTGACTAACGACCCGC TCGAGGCTGCGCATGGGGGTAACGTGCTGATTACGGACACCTGGATCTCCATGG GGCAGGAGGAAGAGAAGAAGAAGAGACTGCAGGCATTCCAGGGGTACCAGGT CACCATGAAAACCGCAAAAGTGGCAGCTTCGGACTGGACTTTCCTGCATTGCCT GCCGAGGAAGCCGGAGGAAGTCGACGACGAAGTGTTCTACTCGCCTCGGTCCC TGGTGTTCCCCGAGGCCGAAAACCGGAAGTGGACCATCATGGCCGTGATGGTG TCCTTGCTGACTGACTATAGCCCGCAGCTGCAGAAGCCTAAGTTCTAGATAAGT GA >pARM1799 (SEQ ID NO: 175) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA >pARM1800 (SEQ ID NO: 176) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA >pARM1801 (SEQ ID NO: 177) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA >pARM1802 (SEQ ID NO: 178) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA ATAAGTGAA >pARM1803 (SEQ ID NO: 179) ATGGGCGTCTTCAACCTGCGGATCCTGCTGAACAACGCCGCCTTCCGGAACGGC CACAACTTCATGGTCCGCAACTTCAGATGCGGCCAGCCCCTGCAGAACAAGGTG CAGCTGAAGGGCCGGGACCTGCTGACCCTGAAGAACTTCACCGGCGAAGAGAT CAAGTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGGATCAAGCAGAAGG GCGAGTACCTGCCCCTGCTGCAAGGCAAGAGCCTGGGCATGATCTTCGAGAAG CGGAGCACCCGGACCCGGCTGAGCACCGAGACAGGCTTTGCCCTGCTGGGAGG CCACCCCTGCTTTCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCT GACCGACACCGCCAGAGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGGG TGTACAAGCAGAGCGACCTGGACACCCTGGCCAAAGAGGCCAGCATCCCCATC ATCAACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTG ACCCTGCAGGAACACTACAGCTCCCTGAAGGGCCTGACCCTGAGCTGGATCGG CGACGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCA TGCATCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCTGATGCCAGCGTGACC AAGCTGGCCGAGCAGTACGCCAAAGAGAACGGCACCAAGCTGCTGCTGACCAA CGACCCCCTGGAAGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGA TCAGCATGGGCCAGGAAGAGGAAAAGAAGAAGCGGCTGCAGGCCTTCCAGGG CTACCAGGTCACAATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCC TGCACTGCCTGCCCCGGAAGCCCGAAGAGGTGGACGACGAGGTGTTCTACAGC CCCCGGTCCCTGGTGTTCCCCGAGGCCGAGAACCGGAAGTGGACCATTATGGCC GTGATGGTGTCCCTGCTGACCGACTACTCCCCCCAGCTGCAGAAGCCCAAGTTC TAGATAAGTGAA >pARM1804 (SEQ ID NO: 180) ATGGGCGTCTTCAACCTGCGGATCCTGCTGAACAACGCCGCCTTCCGGAACGGC CACAACTTCATGGTCCGCAACTTCAGATGCGGCCAGCCCCTGCAGAACAGGGTG CAGCTGAAGGGCCGGGACCTGCTGACCCTGAAGAACTTCACCGGCGAAGAGAT CAGGTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGGATCAAGCAGAAGG GCGAGTACCTGCCCCTGCTGCAAGGCAAGAGCCTGGGCATGATCTTCGAGAAG CGGAGCACCCGGACCCGGCTGAGCACCGAGACAGGCTTTGCCCTGCTGGGAGG CCACCCCTGCTTTCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCT GACCGACACCGCCAGAGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGGG TGTACAAGCAGAGCGACCTGGACACCCTGGCCAAAGAGGCCAGCATCCCCATC ATCAACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTG ACCCTGCAGGAACACTACAGCTCCCTGAAGGGCCTGACCCTGAGCTGGATCGG CGACGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCA TGCATCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCTGATGCCAGCGTGACC AAGCTGGCCGAGCAGTACGCCAAAGAGAACGGCACCAAGCTGCTGCTGACCAA CGACCCCCTGGAAGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGA TCAGCATGGGCCAGGAAGAGGAAAAGAAGAAGCGGCTGCAGGCCTTCCAGGG CTACCAGGTCACAATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCC TGCACTGCCTGCCCCGGAAGCCCGAAGAGGTGGACGACGAGGTGTTCTACAGC CCCCGGTCCCTGGTGTTCCCCGAGGCCGAGAACCGGAAGTGGACCATTATGGCC GTGATGGTGTCCCTGCTGACCGACTACTCCCCCCAGCTGCAGAAGCCCAAGTTC TAGATAAGTGAA >pARM1805 (SEQ ID NO: 181) ATGCTGGTCTTCAACCTGCGGATCCTGCTGAACAACGCCGCCTTCCGGAACGGC CACAACTTCATGGTCCGCAACTTCAGATGCGGCCAGCCCCTGCAGAACAGGGTG CAGCTGAAGGGCCGGGACCTGCTGACCCTGAAGAACTTCACCGGCGAAGAGAT CAGGTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGGATCAAGCAGAAGG GCGAGTACCTGCCCCTGCTGCAAGGCAAGAGCCTGGGCATGATCTTCGAGAAG CGGAGCACCCGGACCCGGCTGAGCACCGAGACAGGCTTTGCCCTGCTGGGAGG CCACCCCTGCTTTCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCT GACCGACACCGCCAGAGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGGG TGTACAAGCAGAGCGACCTGGACACCCTGGCCAAAGAGGCCAGCATCCCCATC ATCAACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTG ACCCTGCAGGAACACTACAGCTCCCTGAAGGGCCTGACCCTGAGCTGGATCGG CGACGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCA TGCATCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCTGATGCCAGCGTGACC AAGCTGGCCGAGCAGTACGCCAAAGAGAACGGCACCAAGCTGCTGCTGACCAA CGACCCCCTGGAAGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGA TCAGCATGGGCCAGGAAGAGGAAAAGAAGAAGCGGCTGCAGGCCTTCCAGGG CTACCAGGTCACAATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCC TGCACTGCCTGCCCCGGAAGCCCGAAGAGGTGGACGACGAGGTGTTCTACAGC CCCCGGTCCCTGGTGTTCCCCGAGGCCGAGAACCGGAAGTGGACCATTATGGCC GTGATGGTGTCCCTGCTGACCGACTACTCCCCCCAGCTGCAGAAGCCCAAGTTC TAGATAAGTGAA >pARM1806 (SEQ ID NO: 182) ATGCTGTTCAACCTGAGGATCCTGCTGAACAACGCAGCTTTCAGGAACGGCCAC AACTTCATGGTGAGGAACTTCCGGTGCGGCCAGCCCCTGCAGAACAAGGTGCA GCTGAAGGGCAGGGACCTGCTGACCCTGAAGAACTTCACCGGAGAGGAGATCA AGTACATGCTGTGGCTGAGCGCAGACCTGAAGTTCAGGATCAAGCAGAAGGGA GAGTACCTGCCCCTGCTGCAGGGGAAGTCCCTGGGCATGATCTTCGAGAAGAG GAGTACCAGGACCAGGCTGAGCACCGAAACCGGCTTCGCCCTGCTGGGAGGAC ACCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGTCTGA CCGACACCGCCAGGGTGCTGTCTAGCATGGCCGACGCCGTGCTGGCCAGGGTGT ACAAGCAGTCAGACCTGGACACCCTGGCTAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCTGACTACCTGACC CTGCAGGAGCACTACAGCTCTCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGGAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCTACCCCCAAGGGTTACGAGCCCGACGCCAGCGTGACCAAG CTGGCAGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGAGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGACAGGAGGAGGAGAAGAAGAAGCGGCTGCAGGCTTTCCAGGGTTAC CAGGTGACCATGAAGACCGCCAAGGTGGCTGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCAGGAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACTCTCCCA GGAGCCTGGTGTTCCCCGAGGCCGAGAACAGGAAGTGGACCATCATGGCTGTG ATGGTGTCCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA ATAAGTGAA >pARM1808 (SEQ ID NO: 183) ATGCTGTTCAACCTGAGGATCCTGCTGAACAACGCAGCTTTCAGGAACGGCCAC AACTTCATGGTGAGGAACTTCCGGTGCGGCCAGCCCCTGCAGAACAAGGTGCA GCTGAAGGGCAGGGACCTGCTGACCCTGAAGAACTTCACCGGAGAGGAGATCA AGTACATGCTGTGGCTGAGCGCAGACCTGAAGTTCAGGATCAAGCAGAAGGGA GAGTACCTGCCCCTGCTGCAGGGGAAGTCCCTGGGCATGATCTTCGAGAAGAG GAGTACCAGGACCAGGCTGAGCACCGAAACCGGCTTCGCCCTGCTGGGAGGAC ACCCCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCA CCGATACCGCCCGGGTGTTATCAAGCATGGCAGATGCCGTGCTGGCCAGGGTGT ACAAACAGTCCGATCTGGACACTCTGGCTAAGGAGGCCAGCATCCCCATCATCA ACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCTGACTACCTGACCC TGCAGGAGCACTACAGCTCTCTGAAGGGCCTGACCCTGAGCTGGATCGGCGAC GGGAACAACATCCTGCACTCCATCATGATGTCCGCCGCGAAGTTCGGAATGCAT CTGCAAGCCGCCACGCCAAAAGGATACGAACCGGATGCGCCCGTGACAAAGTT GGCGGAACAGTACGCTAAGGAGAACGGAACCAAGCTGCTGCTGACCAACGACC CCCTGGAGGCCGCCCACGGAGGCAACGTGCTGATCACCGACACCTGGATCAGC ATGGGACAGGAGGAGGAGAAGAAGAAGCGGCTGCAGGCTTTCCAGGGTTACCA GGTGACCATGAAGACCGCCAAGGTGGCTGCCAGCGACTGGACCTTCCTGCACT GCCTGCCCAGGAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACTCTCCCAGG AGCCTGGTGTTCCCCGAGGCCGAGAACAGGAAGTGGACCATCATGGCTGTGAT GGTGTCCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGAAT AAGTGAA >pARM1809 (SEQ ID NO: 184) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA ATAAGTGAA >pARM1816 (SEQ ID NO: 185) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA ATAAGTGAA >pARM1822 (SEQ ID NO: 186) ATGCTTTTCAACTTGAGAATCCTGCTGAACAACGCCGCCTTTCGCAACGGTCAC AATTTTATGGTCAGAAACTTCAGATGCGGACAGCCCCTCCAAAACAAGGTCCAG CTGAAGGGCCGCGATCTCCTCACCCTGAAGAACTTCACGGGGGAGGAGATCAA GTACATGCTGTGGCTCTCCGCTGACCTGAAGTTCAGGATCAAGCAGAAGGGAG AATATCTGCCGCTGCTGCAAGGGAAGTCCCTGGGGATGATTTTCGAGAAGCGG AGCACCCGGACTCGGCTCTCCACTGAAACTGGTTTCGCCCTTCTGGGCGGTCAC CCCTGCTTCCTGACCACTCAAGACATTCACCTCGGAGTGAACGAGTCCTTGACT GACACCGCCCGGGTGCTGTCGAGCATGGCAGACGCCGTGCTAGCCCGCGTGTA CAAGCAGTCAGACCTCGATACCCTGGCCAAGGAGGCTTCGATCCCGATCATCAA CGGGTTGTCCGACCTGTACCACCCGATTCAGATTCTCGCCGACTACCTCACCCT GCAAGAGCATTACAGCTCCCTGAAGGGGCTTACCCTGTCCTGGATTGGCGACGG AAACAACATCCTGCACTCCATTATGATGTCGGCGGCCAAGTTCGGCATGCACCT CCAAGCCGCGACCCCTAAGGGTTACGAACCAGACGCGTCAGTGACTAAGCTGG CCGAACAGTACGCAAAGGAAAATGGCACGAAGCTGCTCCTGACCAACGATCCG TTGGAAGCCGCCCATGGCGGAAATGTGCTCATCACCGACACCTGGATCTCGATG GGACAGGAGGAAGAGAAGAAGAAGCGGCTGCAGGCGTTCCAGGGCTACCAGG TCACCATGAAAACTGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCACTGCC TTCCGCGCAAGCCTGAGGAGGTGGACGATGAAGTGTTCTACTCTCCACGGTCCC TGGTGTTCCCCGAGGCGGAGAACCGCAAATGGACCATCATGGCTGTGATGGTC AGCCTGCTGACCGATTACAGCCCTCAGTTGCAAAAGCCGAAGTTTTGA >pARM1823 (SEQ ID NO: 187) ATGCTGTTCAACCTCCGCATCCTCCTCAACAACGCCGCATTCAGAAACGGGCAC AACTTCATGGTCAGAAACTTCCGCTGCGGGCAACCCCTACAAAACAAGGTCCA GCTCAAGGGGCGGGACCTCCTGACCCTGAAGAACTTCACCGGCGAAGAGATCA AGTACATGCTGTGGCTCTCCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGA GAGTACCTCCCGCTGCTGCAAGGGAAGTCGCTGGGGATGATCTTCGAGAAGCG GTCAACCAGAACCCGGCTGTCAACCGAAACCGGGTTCGCACTGCTGGGGGGAC ACCCGTGCTTCCTGACCACCCAAGACATCCACCTGGGAGTGAACGAATCGCTGA CCGACACCGCCCGCGTGCTGAGCTCAATGGCGGACGCCGTGCTGGCCCGCGTGT ACAAGCAGTCCGACCTGGACACCCTGGCCAAGGAAGCGTCCATCCCGATCATC AACGGACTGTCCGACCTGTACCACCCGATCCAGATCCTGGCAGACTACCTGACC CTGCAAGAACACTACAGCTCCCTGAAGGGCCTGACCCTGTCATGGATCGGGGA CGGGAACAACATCCTGCACTCCATAATGATGTCAGCCGCCAAGTTCGGAATGCA CCTCCAAGCCGCAACCCCGAAGGGCTACGAACCGGACGCATCAGTGACCAAAC TGGCCGAGCAGTACGCCAAGGAAAACGGCACCAAGCTCCTGCTGACCAACGAC CCGCTGGAGGCCGCACACGGGGGGAACGTGCTGATCACCGACACCTGGATCTC CATGGGACAGGAGGAGGAAAAGAAGAAGCGGCTGCAGGCGTTCCAGGGGTAC CAGGTCACCATGAAAACCGCGAAGGTCGCGGCATCAGACTGGACCTTCCTGCA CTGCCTGCCCCGGAAGCCGGAAGAGGTGGACGACGAGGTGTTCTACTCGCCGC GCTCGCTGGTGTTCCCCGAGGCGGAGAACAGGAAGTGGACCATCATGGCGGTG ATGGTCAGCCTCCTGACCGACTACTCGCCGCAGCTGCAGAAGCCGAAGTTCTGA >pARM1840 (SEQ ID NO: 188) ATGCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGATCAA GTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGGGA ATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACCC CTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCGA TACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAACGG CCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTGCAA GAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGCAAC AACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTTCAA GCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGCCGA GCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCACTAG AAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGGGCC AGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGTCAC CATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCTGCC TCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCCTCG TGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGTCA CTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTGAATAAGTAGA >pARM1841 (SEQ ID NO: 189) ATGCTTTTCAACCTGAGAATCCTCTTGAACAATGCTGCTTTTCGGAATGGCCAC AACTTTATGGTTCGGAACTTCCGTTGCGGCCAGCCTTTACAAAACAAGGTCCAG CTGAAGGGCCGGGATTTGCTCACACTAAAGAACTTTACTGGAGAAGAGATCAA GTACATGCTATGGCTGTCGGCCGACCTGAAGTTCCGTATCAAGCAGAAGGGAG AATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCT CAACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACC CCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCG ATACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACA AACAGTCCGATCTCGATACCTTGGCAAAGGAGGCTTCCATTCCCATCATCAACG GCCTGAGCGACCTGTACCACCCAATCCAAATCCTGGCTGACTACCTGACCCTGC AAGAGCACTACAGCAGCCTGAAGGGTCTGACCCTGTCATGGATTGGCGATGGA AACAATATTCTGCACTCCATCATGATGTCCGCCGCGAAGTTCGGAATGCATCTG CAAGCCGCCACTCCAAAAGGATACGAACCGGATGCATCCGTGACCAAGTTGGC GGAACAGTACGCGAAGGAGAACGGAACCAAGCTCCTGCTGACTAACGACCCGC TCGAGGCTGCGCATGGGGGTAACGTGCTGATTACGGACACCTGGATCTCCATGG GGCAGGAGGAAGAGAAGAAGAAGAGACTGCAGGCATTCCAGGGGTACCAGGT CACCATGAAAACCGCAAAAGTGGCAGCTTCGGACTGGACTTTCCTGCATTGCCT GCCGAGGAAGCCGGAGGAAGTCGACGACGAAGTGTTCTACTCGCCTCGGTCCC TGGTGTTCCCCGAGGCCGAAAACCGGAAGTGGACCATCATGGCCGTGATGGTG TCCTTGCTGACTGACTATAGCCCGCAGCTGCAGAAGCCTAAGTTCTGAATAAGT AGA >pARM1842 (SEQ ID NO: 190) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCCTGGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA ATAAGTAGA >pARM1843 (SEQ ID NO: 191) ATGCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGATCAA GTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGGGA ATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACCC CTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCGA TACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAACGG CCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTGCAA GAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGCAAC AACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTTCAA GCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGCCGA GCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCACTAG AAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGGGCC AGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGTCAC CATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCTGCC TCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCCTCG TGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGTCA CTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAG >pARM1844 (SEQ ID NO: 192) ATGCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGATCAA GTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGGGA ATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACCC CTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCGA TACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAACGG CCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTGCAA GAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGCAAC AACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTTCAA GCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGCCGA GCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCACTAG AAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGGGCC AGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGTCAC CATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCTGCC TCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCCTCG TGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGTCA CTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAG >pARM1845 (SEQ ID NO: 193) ATGCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGATCAA GTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGGGA ATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACCC CTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCGA TACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAACGG CCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTGCAA GAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGCAAC AACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTTCAA GCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGCCGA GCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCACTAG AAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGGGCC AGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGTCAC CATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCTGCC TCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCCTCG TGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGTCA CTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAG >pARM1846 (SEQ ID NO: 194) ATGCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGATCAA GTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGGGA ATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACCC CTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCGA TACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAACGG CCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTGCAA GAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGCAAC AACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTTCAA GCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGCCGA GCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCACTAG AAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGGGCC AGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGTCAC CATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCTGCC TCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCCTCG TGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGTCA CTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAG >pARM1847 (SEQ ID NO: 195) ATGCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGATCAA GTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGGGA ATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACCC CTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCGA TACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAACGG CCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTGCAA GAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGCAAC AACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTTCAA GCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGCCGA GCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCACTAG AAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGGGCC AGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGTCAC CATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCTGCC TCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCCTCG TGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGTCA CTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAG >pARM1882 (SEQ ID NO: 196) ATGGTGTTCAACCTCCGCATCCTCCTCAACAACGCCGCATTCAGAAACGGGCAC AACTTCATGGTCAGAAACTTCCGCTGCGGGCAACCCCTACAAAACAAGGTCCA GCTCAAGGGGCGGGACCTCCTGACCCTGAAGAACTTCACCGGCGAAGAGATCA AGTACATGCTGTGGCTCTCCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGA GAGTACCTCCCGCTGCTGCAAGGGAAGTCGCTGGGGATGATCTTCGAGAAGCG GTCAACCAGAACCCGGCTGTCAACCGAAACCGGGTTCGCACTGCTGGGGGGAC ACCCGTGCTTCCTGACCACCCAAGACATCCACCTGGGAGTGAACGAATCGCTGA CCGACACCGCCCGCGTGCTGAGCTCAATGGCGGACGCCGTGCTGGCCCGCGTGT ACAAGCAGTCCGACCTGGACACCCTGGCCAAGGAAGCGTCCATCCCGATCATC AACGGACTGTCCGACCTGTACCACCCGATCCAGATCCTGGCAGACTACCTGACC CTGCAAGAACACTACAGCTCCCTGAAGGGCCTGACCCTGTCATGGATCGGGGA CGGGAACAACATCCTGCACTCCATAATGATGTCAGCCGCCAAGTTCGGAATGCA CCTCCAAGCCGCAACCCCGAAGGGCTACGAACCGGACGCATCAGTGACCAAAC TGGCCGAGCAGTACGCCAAGGAAAACGGCACCAAGCTCCTGCTGACCAACGAC CCGCTGGAGGCCGCACACGGGGGGAACGTGCTGATCACCGACACCTGGATCTC CATGGGACAGGAGGAGGAAAAGAAGAAGCGGCTGCAGGCGTTCCAGGGGTAC CAGGTCACCATGAAAACCGCGAAGGTCGCGGCATCAGACTGGACCTTCCTGCA CTGCCTGCCCCGGAAGCCGGAAGAGGTGGACGACGAGGTGTTCTACTCGCCGC GCTCGCTGGTGTTCCCCGAGGCGGAGAACAGGAAGTGGACCATCATGGCGGTG ATGGTCAGCCTCCTGACCGACTACTCGCCGCAGCTGCAGAAGCCGAAGTTCTGA >pARM1883 (SEQ ID NO: 197) ATGGTGTTCAACCTCCGCATCCTCCTCAACAACGCCGCATTCAGAAACGGGCAC AACTTCATGGTCAGAAACTTCCGCTGCGGGCAACCCCTACAAAACCGGGTCCAG CTCAAGGGGCGGGACCTCCTGACCCTGAAGAACTTCACCGGCGAAGAGATCAA GTACATGCTGTGGCTCTCCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGAG AGTACCTCCCGCTGCTGCAAGGGAAGTCGCTGGGGATGATCTTCGAGAAGCGG TCAACCAGAACCCGGCTGTCAACCGAAACCGGGTTCGCACTGCTGGGGGGACA CCCGTGCTTCCTGACCACCCAAGACATCCACCTGGGAGTGAACGAATCGCTGAC CGACACCGCCCGCGTGCTGAGCTCAATGGCGGACGCCGTGCTGGCCCGCGTGTA CAAGCAGTCCGACCTGGACACCCTGGCCAAGGAAGCGTCCATCCCGATCATCA ACGGACTGTCCGACCTGTACCACCCGATCCAGATCCTGGCAGACTACCTGACCC TGCAAGAACACTACAGCTCCCTGAAGGGCCTGACCCTGTCATGGATCGGGGAC GGGAACAACATCCTGCACTCCATAATGATGTCAGCCGCCAAGTTCGGAATGCAC CTCCAAGCCGCAACCCCGAAGGGCTACGAACCGGACGCATCAGTGACCAAACT GGCCGAGCAGTACGCCAAGGAAAACGGCACCAAGCTCCTGCTGACCAACGACC CGCTGGAGGCCGCACACGGGGGGAACGTGCTGATCACCGACACCTGGATCTCC ATGGGACAGGAGGAGGAAAAGAAGAAGCGGCTGCAGGCGTTCCAGGGGTACC AGGTCACCATGAAAACCGCGAAGGTCGCGGCATCAGACTGGACCTTCCTGCAC TGCCTGCCCCGGAAGCCGGAAGAGGTGGACGACGAGGTGTTCTACTCGCCGCG CTCGCTGGTGTTCCCCGAGGCGGAGAACAGGAAGTGGACCATCATGGCGGTGA TGGTCAGCCTCCTGACCGACTACTCGCCGCAGCTGCAGAAGCCGAAGTTCTGA >pARM1884 (SEQ ID NO: 198) ATGGTGTTCAACCTCCGCATCCTCCTCAACAACGCCGCATTCAGAAACGGGCAC AACTTCATGGTCAGAAACTTCCGCTGCGGGCAACCCCTACAAAACCGGGTCCAG CTCAAGGGGCGGGACCTCCTGACCCTGAAGAACTTCACCGGCGAAGAGATCCG GTACATGCTGTGGCTCTCCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGAG AGTACCTCCCGCTGCTGCAAGGGAAGTCGCTGGGGATGATCTTCGAGAAGCGG TCAACCAGAACCCGGCTGTCAACCGAAACCGGGTTCGCACTGCTGGGGGGACA CCCGTGCTTCCTGACCACCCAAGACATCCACCTGGGAGTGAACGAATCGCTGAC CGACACCGCCCGCGTGCTGAGCTCAATGGCGGACGCCGTGCTGGCCCGCGTGTA CAAGCAGTCCGACCTGGACACCCTGGCCAAGGAAGCGTCCATCCCGATCATCA ACGGACTGTCCGACCTGTACCACCCGATCCAGATCCTGGCAGACTACCTGACCC TGCAAGAACACTACAGCTCCCTGAAGGGCCTGACCCTGTCATGGATCGGGGAC GGGAACAACATCCTGCACTCCATAATGATGTCAGCCGCCAAGTTCGGAATGCAC CTCCAAGCCGCAACCCCGAAGGGCTACGAACCGGACGCATCAGTGACCAAACT GGCCGAGCAGTACGCCAAGGAAAACGGCACCAAGCTCCTGCTGACCAACGACC CGCTGGAGGCCGCACACGGGGGGAACGTGCTGATCACCGACACCTGGATCTCC ATGGGACAGGAGGAGGAAAAGAAGAAGCGGCTGCAGGCGTTCCAGGGGTACC AGGTCACCATGAAAACCGCGAAGGTCGCGGCATCAGACTGGACCTTCCTGCAC TGCCTGCCCCGGAAGCCGGAAGAGGTGGACGACGAGGTGTTCTACTCGCCGCG CTCGCTGGTGTTCCCCGAGGCGGAGAACAGGAAGTGGACCATCATGGCGGTGA TGGTCAGCCTCCTGACCGACTACTCGCCGCAGCTGCAGAAGCCGAAGTTCTGA >pARM1885 (SEQ ID NO: 199) ATGCTGGTCAACCTCCGCATCCTCCTCAACAACGCCGCATTCAGAAACGGGCAC AACTTCATGGTCAGAAACTTCCGCTGCGGGCAACCCCTACAAAACAAGGTCCA GCTCAAGGGGCGGGACCTCCTGACCCTGAAGAACTTCACCGGCGAAGAGATCA AGTACATGCTGTGGCTCTCCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGA GAGTACCTCCCGCTGCTGCAAGGGAAGTCGCTGGGGATGATCTTCGAGAAGCG GTCAACCAGAACCCGGCTGTCAACCGAAACCGGGTTCGCACTGCTGGGGGGAC ACCCGTGCTTCCTGACCACCCAAGACATCCACCTGGGAGTGAACGAATCGCTGA CCGACACCGCCCGCGTGCTGAGCTCAATGGCGGACGCCGTGCTGGCCCGCGTGT ACAAGCAGTCCGACCTGGACACCCTGGCCAAGGAAGCGTCCATCCCGATCATC AACGGACTGTCCGACCTGTACCACCCGATCCAGATCCTGGCAGACTACCTGACC CTGCAAGAACACTACAGCTCCCTGAAGGGCCTGACCCTGTCATGGATCGGGGA CGGGAACAACATCCTGCACTCCATAATGATGTCAGCCGCCAAGTTCGGAATGCA CCTCCAAGCCGCAACCCCGAAGGGCTACGAACCGGACGCATCAGTGACCAAAC TGGCCGAGCAGTACGCCAAGGAAAACGGCACCAAGCTCCTGCTGACCAACGAC CCGCTGGAGGCCGCACACGGGGGGAACGTGCTGATCACCGACACCTGGATCTC CATGGGACAGGAGGAGGAAAAGAAGAAGCGGCTGCAGGCGTTCCAGGGGTAC CAGGTCACCATGAAAACCGCGAAGGTCGCGGCATCAGACTGGACCTTCCTGCA CTGCCTGCCCCGGAAGCCGGAAGAGGTGGACGACGAGGTGTTCTACTCGCCGC GCTCGCTGGTGTTCCCCGAGGCGGAGAACAGGAAGTGGACCATCATGGCGGTG ATGGTCAGCCTCCTGACCGACTACTCGCCGCAGCTGCAGAAGCCGAAGTTCTGA >pARM1886 (SEQ ID NO: 200) ATGCTGGTCAACCTCCGCATCCTCCTCAACAACGCCGCATTCAGAAACGGGCAC AACTTCATGGTCAGAAACTTCCGCTGCGGGCAACCCCTACAAAACCGGGTCCAG CTCAAGGGGCGGGACCTCCTGACCCTGAAGAACTTCACCGGCGAAGAGATCAA GTACATGCTGTGGCTCTCCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGAG AGTACCTCCCGCTGCTGCAAGGGAAGTCGCTGGGGATGATCTTCGAGAAGCGG TCAACCAGAACCCGGCTGTCAACCGAAACCGGGTTCGCACTGCTGGGGGGACA CCCGTGCTTCCTGACCACCCAAGACATCCACCTGGGAGTGAACGAATCGCTGAC CGACACCGCCCGCGTGCTGAGCTCAATGGCGGACGCCGTGCTGGCCCGCGTGTA CAAGCAGTCCGACCTGGACACCCTGGCCAAGGAAGCGTCCATCCCGATCATCA ACGGACTGTCCGACCTGTACCACCCGATCCAGATCCTGGCAGACTACCTGACCC TGCAAGAACACTACAGCTCCCTGAAGGGCCTGACCCTGTCATGGATCGGGGAC GGGAACAACATCCTGCACTCCATAATGATGTCAGCCGCCAAGTTCGGAATGCAC CTCCAAGCCGCAACCCCGAAGGGCTACGAACCGGACGCATCAGTGACCAAACT GGCCGAGCAGTACGCCAAGGAAAACGGCACCAAGCTCCTGCTGACCAACGACC CGCTGGAGGCCGCACACGGGGGGAACGTGCTGATCACCGACACCTGGATCTCC ATGGGACAGGAGGAGGAAAAGAAGAAGCGGCTGCAGGCGTTCCAGGGGTACC AGGTCACCATGAAAACCGCGAAGGTCGCGGCATCAGACTGGACCTTCCTGCAC TGCCTGCCCCGGAAGCCGGAAGAGGTGGACGACGAGGTGTTCTACTCGCCGCG CTCGCTGGTGTTCCCCGAGGCGGAGAACAGGAAGTGGACCATCATGGCGGTGA TGGTCAGCCTCCTGACCGACTACTCGCCGCAGCTGCAGAAGCCGAAGTTCTGA >pARM1887 (SEQ ID NO: 201) ATGCTGGTCAACCTCCGCATCCTCCTCAACAACGCCGCATTCAGAAACGGGCAC AACTTCATGGTCAGAAACTTCCGCTGCGGGCAACCCCTACAAAACCGGGTCCAG CTCAAGGGGCGGGACCTCCTGACCCTGAAGAACTTCACCGGCGAAGAGATCCG GTACATGCTGTGGCTCTCCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGAG AGTACCTCCCGCTGCTGCAAGGGAAGTCGCTGGGGATGATCTTCGAGAAGCGG TCAACCAGAACCCGGCTGTCAACCGAAACCGGGTTCGCACTGCTGGGGGGACA CCCGTGCTTCCTGACCACCCAAGACATCCACCTGGGAGTGAACGAATCGCTGAC CGACACCGCCCGCGTGCTGAGCTCAATGGCGGACGCCGTGCTGGCCCGCGTGTA CAAGCAGTCCGACCTGGACACCCTGGCCAAGGAAGCGTCCATCCCGATCATCA ACGGACTGTCCGACCTGTACCACCCGATCCAGATCCTGGCAGACTACCTGACCC TGCAAGAACACTACAGCTCCCTGAAGGGCCTGACCCTGTCATGGATCGGGGAC GGGAACAACATCCTGCACTCCATAATGATGTCAGCCGCCAAGTTCGGAATGCAC CTCCAAGCCGCAACCCCGAAGGGCTACGAACCGGACGCATCAGTGACCAAACT GGCCGAGCAGTACGCCAAGGAAAACGGCACCAAGCTCCTGCTGACCAACGACC CGCTGGAGGCCGCACACGGGGGGAACGTGCTGATCACCGACACCTGGATCTCC ATGGGACAGGAGGAGGAAAAGAAGAAGCGGCTGCAGGCGTTCCAGGGGTACC AGGTCACCATGAAAACCGCGAAGGTCGCGGCATCAGACTGGACCTTCCTGCAC TGCCTGCCCCGGAAGCCGGAAGAGGTGGACGACGAGGTGTTCTACTCGCCGCG CTCGCTGGTGTTCCCCGAGGCGGAGAACAGGAAGTGGACCATCATGGCGGTGA TGGTCAGCCTCCTGACCGACTACTCGCCGCAGCTGCAGAAGCCGAAGTTCTGA >pARM1888 (SEQ ID NO: 202) ATGCTGGTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA >pARM1889 (SEQ ID NO: 203) ATGCTGGTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACCGGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA >pARM1890 (SEQ ID NO: 204) ATGCTTGTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAGGTCCAG CTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGATCAA GTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGGGA ATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACCC CTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCGA TACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAACGG CCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTGCAA GAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGCAAC AACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTTCAA GCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGCCGA GCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCACTAG AAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGGGCC AGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGTCAC CATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCTGCC TCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCCTCG TGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGTCA CTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAG >pARM1891 (SEQ ID NO: 205) ATGCTTGTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGCCAC AACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACCGGGTCCAG CTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGATCAA GTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGGGGA ATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCGCTC AACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCACCC CTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCACCGA TACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTACAA ACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAACGG CCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTGCAA GAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGCAAC AACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTTCAA GCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGCCGA GCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCACTAG AAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGGGCC AGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGTCAC CATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCTGCC TCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCCTCG TGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGTCA CTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAG >pARM1898 (SEQ ID NO: 206) ATGGGCCTTGTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGC CACAACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAGGTC CAGCTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGAT CAAGTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGG GGAATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCG CTCAACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCA CCCCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCAC CGATACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTA CAAACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAA CGGCCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTG CAAGAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGC AACAACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTT CAAGCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGC CGAGCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCAC TAGAAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGG GCCAGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGT CACCATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCT GCCTCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCC TCGTGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGT CACTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAG >pARM1899 (SEQ ID NO: 207) ATGGGCCTTGTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGC CACAACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACCGGGTC CAGCTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGAT CAAGTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGG GGAATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCG CTCAACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCA CCCCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCAC CGATACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTA CAAACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAA CGGCCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTG CAAGAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGC AACAACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTT CAAGCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGC CGAGCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCAC TAGAAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGG GCCAGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGT CACCATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCT GCCTCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCC TCGTGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGT CACTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAG >pARM1900 (SEQ ID NO: 208) ATGGGCGGACTTGTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAAC GGCCACAACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAAACAAG GTCCAGCTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGA GATCAAGTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAA GGGGGAATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAA GCGCTCAACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGG CCACCCCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCT CACCGATACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGT GTACAAACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTAT CAACGGCCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCAC CCTGCAAGAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGA CGGCAACAACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCA TCTTCAAGCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCT CGCCGAGCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACC CACTAGAAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCA TGGGCCAGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCA GGTCACCATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTG CCTGCCTCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGA GCCTCGTGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATG GTGTCACTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAG >pARM1903 (SEQ ID NO: 209) ATGGCCCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGC CACAACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAGGCAAGGTC CAGCTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGAT CAAGTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGG GGAATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCG CTCAACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCA CCCCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCAC CGATACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTA CAAACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAA CGGCCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTG CAAGAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGC AACAACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTT CAAGCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGC CGAGCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCAC TAGAAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGG GCCAGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGT CACCATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCT GCCTCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCC TCGTGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGT CACTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAGATAAGTG AA >pARM1904 (SEQ ID NO: 210) ATGGCCCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGC CACAACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAGGCCGGGTC CAGCTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGAT CAAGTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGG GGAATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCG CTCAACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCA CCCCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCAC CGATACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTA CAAACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAA CGGCCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTG CAAGAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGC AACAACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTT CAAGCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGC CGAGCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCAC TAGAAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGG GCCAGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGT CACCATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCT GCCTCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCC TCGTGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGT CACTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAGATAAGTG AA >pARM1905 (SEQ ID NO: 211) ATGGCCCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGC CACAACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAGGCCGGGTC CAGCTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGAT CAGGTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGG GGAATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCG CTCAACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCA CCCCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCAC CGATACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTA CAAACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAA CGGCCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTG CAAGAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGC AACAACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTT CAAGCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGC CGAGCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCAC TAGAAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGG GCCAGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGT CACCATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCT GCCTCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCC TCGTGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGT CACTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAGATAAGTG AA >pARM1906 (SEQ ID NO: 212) ATGGCCCTTGTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGC CACAACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAGGCAGGGTC CAGCTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGAT CAAGTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGG GGAATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCG CTCAACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCA CCCCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCAC CGATACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTA CAAACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAA CGGCCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTG CAAGAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGC AACAACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTT CAAGCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGC CGAGCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCAC TAGAAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGG GCCAGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGT CACCATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCT GCCTCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCC TCGTGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGT CACTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAAGTGAATA GA >pARM1907 (SEQ ID NO: 213) ATGGCCCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGC CACAACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAGTCAAGGTC CAGCTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGAT CAAGTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGG GGAATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCG CTCAACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCA CCCCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCAC CGATACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTA CAAACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAA CGGCCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTG CAAGAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGC AACAACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTT CAAGCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGC CGAGCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCAC TAGAAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGG GCCAGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGT CACCATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCT GCCTCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCC TCGTGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGT CACTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAGATAAGTG AA >pARM1908 (SEQ ID NO: 214) ATGGCCCTTTTCAATCTCCGCATCCTCCTTAACAACGCCGCGTTTAGAAACGGC CACAACTTCATGGTCCGGAACTTCAGATGTGGCCAGCCGCTTCAAGTCAGGGTC CAGCTGAAGGGCCGGGATCTTCTGACCCTGAAGAACTTTACTGGCGAAGAGAT CAAGTACATGCTCTGGCTCTCCGCGGACTTGAAGTTCCGCATTAAGCAGAAGGG GGAATACCTTCCGCTGCTTCAAGGAAAGAGCCTCGGCATGATCTTTGAGAAGCG CTCAACCAGGACCCGCCTTTCTACTGAAACTGGGTTCGCGCTGCTCGGTGGCCA CCCCTGCTTCCTGACGACCCAGGACATCCACCTCGGAGTGAACGAATCCCTCAC CGATACCGCCCGGGTGTTATCGAGCATGGCAGATGCCGTGCTGGCCAGGGTGTA CAAACAGTCCGATCTGGACACTCTGGCCAAGGAGGCGTCAATTCCTATTATCAA CGGCCTTAGTGACCTCTACCATCCGATTCAGATCCTGGCCGATTACCTCACCCTG CAAGAACACTACAGCTCCCTGAAGGGTCTGACATTGTCCTGGATCGGCGACGGC AACAACATTCTCCATTCCATCATGATGTCCGCCGCAAAATTCGGCATGCATCTT CAAGCCGCCACGCCGAAGGGTTACGAGCCCGACGCTTCCGTGACTAAGCTCGC CGAGCAGTACGCTAAGGAGAACGGAACCAAGCTTCTGCTGACTAACGACCCAC TAGAAGCAGCCCACGGGGGCAACGTGCTTATTACTGACACCTGGATCTCCATGG GCCAGGAAGAAGAGAAAAAGAAGCGGCTGCAGGCGTTCCAGGGATATCAGGT CACCATGAAAACCGCCAAGGTCGCTGCCTCCGACTGGACCTTCCTGCACTGCCT GCCTCGCAAGCCTGAAGAAGTGGACGACGAGGTGTTCTACTCGCCACGGAGCC TCGTGTTCCCCGAGGCCGAGAATAGAAAGTGGACCATCATGGCCGTGATGGTGT CACTGCTCACCGACTACAGCCCGCAGCTTCAGAAGCCCAAGTTCTAGATAAGTG AA >pARM1915 (SEQ ID NO: 215) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA >pARM1916 (SEQ ID NO: 216) ATGGGAGTATTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGC CACAACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTG CAGCTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGAT CAAGTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGG GCGAGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAG CGCAGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGG CCACCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCT GACCGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCG TGTACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATC ATCAACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTG ACCCTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGG CGACGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCA TGCACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACC AAGCTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAA CGACCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGA TCAGCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGC TACCAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCT GCACTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCC CCCGCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCC GTGATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTC TGA >pARM1917 (SEQ ID NO: 217) ATGGGAGTATTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGC CACAACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACCGGGTG CAGCTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGAT CCGGTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGG GCGAGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAG CGCAGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGG CCACCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCT GACCGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCG TGTACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATC ATCAACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTG ACCCTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGG CGACGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCA TGCACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACC AAGCTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAA CGACCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGA TCAGCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGC TACCAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCT GCACTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCC CCCGCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCC GTGATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTC TGA >pARM1918 (SEQ ID NO: 218) ATGCTGGTATTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGC CACAACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACCGGGTG CAGCTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGAT CCGGTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGG GCGAGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAG CGCAGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGG CCACCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCT GACCGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCG TGTACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATC ATCAACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTG ACCCTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGG CGACGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCA TGCACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACC AAGCTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAA CGACCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGA TCAGCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGC TACCAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCT GCACTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCC CCCGCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCC GTGATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTC TGA >pARM1919 (SEQ ID NO: 219) ATGGGAGTATTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGC CACAACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTG CAGCTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGAT CAAGTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGG GCGAGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAG CGCAGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGG CCACCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCT GACCGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCG TGTACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATC ATCAACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTG ACCCTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGG CGACGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCA TGCACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACC AAGCTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAA CGACCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGA TCAGCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGC TACCAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCT GCACTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCC CCCGCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCC GTGATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTC TGA >pARM1920 (SEQ ID NO: 220) ATGGGAGTATTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGC CACAACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACCGGGTG CAGCTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGAT CCGGTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGG GCGAGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAG CGCAGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGG CCACCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCT GACCGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCG TGTACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATC ATCAACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTG ACCCTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGG CGACGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCA TGCACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACC AAGCTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAA CGACCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGA TCAGCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGC TACCAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCT GCACTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCC CCCGCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCC GTGATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTC TGA >pARM1921 (SEQ ID NO: 221) ATGCTGGTATTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGC CACAACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACCGGGTG CAGCTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGAT CCGGTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGG GCGAGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAG CGCAGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGG CCACCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCT GACCGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCG TGTACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATC ATCAACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTG ACCCTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGG CGACGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCA TGCACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACC AAGCTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAA CGACCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGA TCAGCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGC TACCAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCT GCACTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCC CCCGCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCC GTGATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTC TGA >pARM1925 (SEQ ID NO: 222) ATGTTGTTCAACTTGAGGATCTTGTTGAACAACGCCGCCTTCAGGAACGGACAC AACTTCATGGTAAGGAACTTCAGGTGCGGACAGCCCTTGCAGAACAAAGTACA GTTGAAAGGAAGGGACTTGTTGACATTGAAAAACTTCACAGGAGAAGAAATCA AATACATGTTGTGGTTGTCGGCCGACTTGAAATTCAGGATCAAACAGAAAGGA GAATACTTGCCCTTGTTGCAGGGAAAATCGTTGGGAATGATCTTCGAAAAAAGG TCGACAAGGACAAGGTTGTCGACAGAAACAGGATTCGCCTTGTTGGGAGGACA CCCCTGCTTCTTGACAACACAGGACATCCACTTGGGAGTAAACGAATCGTTGAC AGACACAGCCAGGGTATTGTCGTCGATGGCCGACGCCGTATTGGCCAGGGTAT ACAAACAGTCGGACTTGGACACATTGGCCAAAGAAGCCTCGATCCCCATCATC AACGGATTGTCGGACTTGTACCACCCCATCCAGATCTTGGCCGACTACTTGACA TTGCAGGAACACTACTCGTCGTTGAAAGGATTGACATTGTCGTGGATCGGAGAC GGAAACAACATCTTGCACTCGATCATGATGTCGGCCGCCAAATTCGGAATGCAC TTGCAGGCCGCCACACCCAAAGGATACGAACCCGACGCCTCGGTAACAAAATT GGCCGAACAGTACGCCAAAGAAAACGGAACAAAATTGTTGTTGACAAACGACC CCTTGGAAGCCGCCCACGGAGGAAACGTATTGATCACAGACACATGGATCTCG ATGGGACAGGAAGAAGAAAAAAAAAAAAGGTTGCAGGCCTTCCAGGGATACC AGGTAACAATGAAAACAGCCAAAGTAGCCGCCTCGGACTGGACATTCTTGCAC TGCTTGCCCAGGAAACCCGAAGAAGTAGACGACGAAGTATTCTACTCGCCCAG GTCGTTGGTATTCCCCGAAGCCGAAAACAGGAAATGGACAATCATGGCCGTAA TGGTATCGTTGTTGACAGACTACTCGCCCCAGTTGCAGAAACCCAAATTCTGAA TAGTGAA >pARM1926 (SEQ ID NO: 223) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGGGCAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA >pARM1927 (SEQ ID NO: 224) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGGGCCGGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA >pARM1928 (SEQ ID NO: 225) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGGGCCGGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCCG GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA >pARM1929 (SEQ ID NO: 226) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGGGCAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA >pARM2016 (SEQ ID NO: 227) ATGCTGTTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGCCAC AACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACAAGGTGCAG CTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGATCAA GTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGGGCG AGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAGCGC AGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGGCCA CCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCTGAC CGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCGTGT ACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATCATC AACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTGACC CTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGGCGA CGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCATGC ACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACCAAG CTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAACGA CCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGATCA GCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGCTAC CAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCTGCA CTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCCCCC GCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCCGTG ATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTCTGA >pARM2260 (SEQ ID NO: 228) ATGCTGGTATTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGC CACAACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACCGGGTG CAGCTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGAT CCGGTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGG GCGAGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAG CGCAGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGG CCACCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCT GACCGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCG TGTACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATC ATCAACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTG ACCCTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGG CGACGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCA TGCACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACC AAGCTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAA CGACCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGA TCAGCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGC TACCAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCT GCACTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCC CCCGCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCC GTGATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTC TGA >pARM2262 (SEQ ID NO: 229) ATGCTGGTATTCAACCTGCGCATCCTGCTGAACAACGCCGCCTTCCGCAACGGC CACAACTTCATGGTGCGCAACTTCCGCTGCGGCCAGCCCCTGCAGAACCGGGTG CAGCTGAAGGGCCGCGACCTGCTGACCCTGAAGAACTTCACCGGCGAGGAGAT CCGGTACATGCTGTGGCTGAGCGCCGACCTGAAGTTCCGCATCAAGCAGAAGG GCGAGTACCTGCCCCTGCTGCAGGGCAAGAGCCTGGGCATGATCTTCGAGAAG CGCAGCACCCGCACCCGCCTGAGCACCGAGACAGGCTTCGCCCTGCTGGGCGG CCACCCCTGCTTCCTGACCACCCAGGACATCCACCTGGGCGTGAACGAGAGCCT GACCGACACCGCCCGCGTGCTGAGCAGCATGGCCGACGCCGTGCTGGCCCGCG TGTACAAGCAGAGCGACCTGGACACCCTGGCCAAGGAGGCCAGCATCCCCATC ATCAACGGCCTGAGCGACCTGTACCACCCCATCCAGATCCTGGCCGACTACCTG ACCCTGCAGGAGCACTACAGCAGCCTGAAGGGCCTGACCCTGAGCTGGATCGG CGACGGCAACAACATCCTGCACAGCATCATGATGAGCGCCGCCAAGTTCGGCA TGCACCTGCAGGCCGCCACCCCCAAGGGCTACGAGCCCGACGCCAGCGTGACC AAGCTGGCCGAGCAGTACGCCAAGGAGAACGGCACCAAGCTGCTGCTGACCAA CGACCCCCTGGAGGCCGCCCACGGCGGCAACGTGCTGATCACCGACACCTGGA TCAGCATGGGCCAGGAGGAGGAGAAGAAGAAGCGCCTGCAGGCCTTCCAGGGC TACCAGGTGACCATGAAGACCGCCAAGGTGGCCGCCAGCGACTGGACCTTCCT GCACTGCCTGCCCCGCAAGCCCGAGGAGGTGGACGACGAGGTGTTCTACAGCC CCCGCAGCCTGGTGTTCCCCGAGGCCGAGAACCGCAAGTGGACCATCATGGCC GTGATGGTGAGCCTGCTGACCGACTACAGCCCCCAGCTGCAGAAGCCCAAGTTC TGA AT5G61250 AACCAAUCGAAAGAAACCAAA SEQ ID NO: 230 AT5G46430 CUCUAAUCACCAGGAGUAAAA SEQ ID NO: 231 AT5G47110 GAGAGAGAUCUUAACAAAAAA SEQ ID NO: 232 AT1G03110 UGUGUAACAACAACAACAACA SEQ ID NO: 233 AT3G12380 CCGCAGUAGGAAGAGAAAGCC SEQ ID NO: 234 AT5G45910 AAAAAAAAAAGAAAUCAUAAA SEQ ID NO: 235 AT1G07260 GAGAGAAGAAAGAAGAAGACG SEQ ID NO: 236 AT3G55500 CAAUUAAAAAUACUUACCAAA SEQ ID NO: 237 AT3G46230 GCAAACAGAGUAAGCGAAACG SEQ ID NO: 238 AT2G36170 GCGAAGAAGACGAACGCAAAG SEQ ID NO: 239 AT1G10660 UUAGGACUGUAUUGACUGGCC SEQ ID NO: 240 AT4G14340 AUCAUCGGAAUUCGGAAAAAG SEQ ID NO: 241 AT1G49310 AAAACAAAAGUUAAAGCAGAC SEQ ID NO: 242 AT4G14360 UUUAUCUCAAAUAAGAAGGCA SEQ ID NO: 243 AT1G28520 GGUGGGGAGGUGAGAUUUCUU SEQ ID NO: 244 AT1G20160 UGAUUAGGAAACUACAAAGCC SEQ ID NO: 245 AT5G37370 CAUUUUUCAAUUUCAUAAAAC SEQ ID NO: 246 AT4G11320 UUACUUUUAAGCCCAACAAAA SEQ ID NO: 247 AT5G40850 GGCGUGUGUGUGUGUUGUUGA SEQ ID NO: 248 AT1G06150 GUGGUGAAGGGGAAGGUUUAG SEQ ID NO: 249 AT2G26080 UUGUUUUUUUUUGGUUUGGUU SEQ ID NO: 250 mARM2260 (SEQ ID NO: 251) AGGAUUAUUACAUCAAAACAAAAAGCCGCCACCAUGCUGGUAUUCAACCUGC GCAUCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCG CAACUUCCGCUGCGGCCAGCCCCUGCAGAACCGGGUGCAGCUGAAGGGCCGC GACCUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCCGGUACAUGCUGU GGCUGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCC CCUGCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGC ACCCGCCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCUGCUU CCUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACC GCCCGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGC AGAGCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGG CCUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGC AGGAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGG CAACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCAC CUGCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCU GGCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGAC CCCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCA GCAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUA CCAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUG CACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCC CCCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGC CGUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAG UUCUGAGGUCUCUAGUAAUGAGCUGGAGCCUCGGUAGCCGUUCCUCCUGCCC GCUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUCCUGGUC UUUGAAUAAAGUCUGAGUGGGCAGCAUCUAGAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAA mARM2262 (SEQ ID NO: 252) AGGAUUAUUACAUCAAAACAAAAAGCCGCCACCAUGCUGGUAUUCAACCUGC GCAUCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCG CAACUUCCGCUGCGGCCAGCCCCUGCAGAACCGGGUGCAGCUGAAGGGCCGC GACCUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCCGGUACAUGCUGU GGCUGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCC CCUGCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGC ACCCGCCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCUGCUU CCUGACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACC GCCCGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGC AGAGCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGG CCUGAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGC AGGAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGG CAACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCAC CUGCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCU GGCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGAC CCCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCA GCAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUA CCAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUG CACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCC CCCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGC CGUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAG UUCUGAGGUCUCUAGUAAUGAGCUGGAGCCUCGGUAGCCGUUCCUCCUGCCC GCUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUCCUGGUC UUUGAAUAAAGUCUGAGUGGGCAGCAUCUAGAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAGCU mARM2016 (SEQ ID NO: 253) AGGAUUAUUACAUCAAAACAAAAAGCCGCCACCAUGCUGUUCAACCUGCGCA UCCUGCUGAACAACGCCGCCUUCCGCAACGGCCACAACUUCAUGGUGCGCAA CUUCCGCUGCGGCCAGCCCCUGCAGAACAAGGUGCAGCUGAAGGGCCGCGAC CUGCUGACCCUGAAGAACUUCACCGGCGAGGAGAUCAAGUACAUGCUGUGGC UGAGCGCCGACCUGAAGUUCCGCAUCAAGCAGAAGGGCGAGUACCUGCCCCU GCUGCAGGGCAAGAGCCUGGGCAUGAUCUUCGAGAAGCGCAGCACCCGCACC CGCCUGAGCACCGAGACAGGCUUCGCCCUGCUGGGCGGCCACCCCUGCUUCCU GACCACCCAGGACAUCCACCUGGGCGUGAACGAGAGCCUGACCGACACCGCC CGCGUGCUGAGCAGCAUGGCCGACGCCGUGCUGGCCCGCGUGUACAAGCAGA GCGACCUGGACACCCUGGCCAAGGAGGCCAGCAUCCCCAUCAUCAACGGCCU GAGCGACCUGUACCACCCCAUCCAGAUCCUGGCCGACUACCUGACCCUGCAG GAGCACUACAGCAGCCUGAAGGGCCUGACCCUGAGCUGGAUCGGCGACGGCA ACAACAUCCUGCACAGCAUCAUGAUGAGCGCCGCCAAGUUCGGCAUGCACCU GCAGGCCGCCACCCCCAAGGGCUACGAGCCCGACGCCAGCGUGACCAAGCUG GCCGAGCAGUACGCCAAGGAGAACGGCACCAAGCUGCUGCUGACCAACGACC CCCUGGAGGCCGCCCACGGCGGCAACGUGCUGAUCACCGACACCUGGAUCAG CAUGGGCCAGGAGGAGGAGAAGAAGAAGCGCCUGCAGGCCUUCCAGGGCUAC CAGGUGACCAUGAAGACCGCCAAGGUGGCCGCCAGCGACUGGACCUUCCUGC ACUGCCUGCCCCGCAAGCCCGAGGAGGUGGACGACGAGGUGUUCUACAGCCC CCGCAGCCUGGUGUUCCCCGAGGCCGAGAACCGCAAGUGGACCAUCAUGGCC GUGAUGGUGAGCCUGCUGACCGACUACAGCCCCCAGCUGCAGAAGCCCAAGU UCUGAGGUCUCUAGUAAUGAGCUGGAGCCUCGGUAGCCGUUCCUCCUGCCCG CUGGGCCUCCCAACGGGCCCUCCUCCCCUCCUUGCACCGGCCCUUCCUGGUCU UUGAAUAAAGUCUGAGUGGGCAGCAUCUAGAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAA