CRYSTALLOGRAPHIC ORIENTATION STRUCTURED TITANIUM ALLOY DENTAL IMPLANT AND MANUFACTURING METHOD THEREOF

Abstract

The present invention provides a crystallographic orientation structured titanium alloy dental implant and manufacturing method thereof. The technique of modifying the surface structure (Ti/TiO.sub.2, amorphous) of the titanium alloy dental implant to form a [Ti/TiO.sub.2 anatase (215)] crystallographic orientation structure is applied in osseointegration field for improving activity of osteocyte, shortening the identification period of initial growth of osteocyte, accelerating the integration of human bone and the calcification of osteocyte tissue, with the advantage of healing wound fast, therefore being suitable for clinical treatment of dental implant surgery. The structure is relatively stable, uneasy to be worn and damage proof, not affected by the surface roughness, and assures the hydrophilicity of the adherence capacity of osteocyte. The structure features a specific crystal grains arrangement direction (crystallographic orientation) so as to increase cell activity, hydrophilicity, and biocompatibility.

Claims

1. A manufacturing method of a crystallographic orientation structured titanium alloy dental implant, comprising following steps: (1) providing a titanium alloy dental implant sample having a chemical composition of Ti-6% Al-4% V; (2) placing the titanium alloy dental implant sample on an anode, and controlling an electrolysis and oxidation mechanism, and electrolyzing the titanium metal to produce a crystal grains arrangement direction; (3) oxidation and formation of a crystallographic orientation structure, the titanium metal producing a crystal grains arrangement, promoting the oxidation and formation of the crystallographic orientation structure, which includes a deposition of an oxide layer structure with a specific crystal grains arrangement direction (crystallographic orientation), wherein the direction is a HRXRD diffraction direction of the oxide layer structure; and (4) producing the crystallographic orientation structure having a composition of [Ti/TiO.sub.2 anatase (215)], wherein a metal activity is Ti>Al>V.

2. The manufacturing method of claim 1, wherein a grain growth method is that metal titanium ions and O.sub.2 chemically react and deposit to form a biomedical ceramic oxide layer structure.

3. The manufacturing method of claim 1, wherein according to a result by high-resolution X-ray diffraction (HRXRD), the crystallographic orientation structure composition thereof is [Ti/TiO.sub.2 anatase (215)], with the specific crystal grains arrangement direction (crystallographic orientation), and the direction is a HRXRD diffraction direction (215) diffraction surface of the TiO.sub.2 anatase oxide layer structure, with a diffraction peak value of 20=75 degrees.

4. The manufacturing method of claim 1, wherein a titanium alloy electrolysis is applied; to control the electrolysis and oxidation mechanism to electrolyze the metal to produces the crystal grains arrangement direction, an electrolyte formulation with a 5 vol % water content is used.

5. The manufacturing method of claim 1, wherein a technology of the manufacturing method is applied to metal industry, aerospace industry, and medical materials industry.

6. A crystallographic orientation structured titanium alloy dental implant manufactured by the manufacturing method of claim 1, the crystallographic orientation structured titanium alloy implant comprising: a titanium alloy implant; and a crystallographic orientation structure, including an oxide layer deposition structure formed on the titanium alloy implant through the electrolysis and oxidation mechanism, and the specific crystal grains arrangement direction (crystallographic orientation).

7. The crystallographic orientation structured titanium alloy dental implant of claim 6, wherein the titanium alloy implant has a thread portion on one end, and a fix portion on the other end.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0013] FIG. 1 is a schematic diagram of X-ray diffraction according to an embodiment of the present invention.

[0014] FIG. 2 is a schematic diagram of X-ray diffraction according to a comparative example of the present invention.

[0015] FIG. 3 is a schematic diagram of the cell survival rate analysis of MTT.

[0016] FIG. 4 is a perspective view of the crystallographic orientation structured titanium alloy dental implant in accordance with an embodiment of the present invention.

[0017] FIG. 5 is a cross-sectional view and partially enlarged view taken along line 5-5 of FIG. 4.

DETAILED DESCRIPTION OF THE INVENTION

[0018] Referring to FIG. 5, the present invention provides a crystallographic orientation structured titanium alloy dental implant and manufacturing method thereof.

[0019] The manufacturing method is illustrated as follows.

[0020] (1) The chemical composition of the titanium alloy dental implant sample is Ti-6% Al-4% V.

[0021] (2) The titanium alloy dental implant sample is placed on the anode, and the electrolysis and oxidation mechanism are controlled, so that the electrolyzed titanium metal produces a crystal grains arrangement direction.

[0022] (3) Oxidation and formation of crystallographic orientation structure: Titanium metal produces crystal grains arrangement and promotes oxidation to form the crystallographic orientation structure, which includes the deposition of an oxide layer structure with a specific crystal grains arrangement direction (crystallographic orientation), wherein the direction is the HRXRD diffraction direction of the oxide layer structure.

[0023] (4) The crystallographic orientation structure composition accordingly manufactured is [Ti/TiO.sub.2 anatase (215)], wherein the metal activity is Ti>Al>V.

[0024] The crystallographic orientation structure composition is represented as [Mx/MxO(hkl)]; the metal activity is Mx>My, wherein Mx and My are metal elements, and MxO is Mx metal oxide, and MxO(hkl) is the HRXRD diffraction direction thereof.

[0025] The formula and parameters of the electrolyte of titanium alloy electrolysis development technology are shown as follows:

[0026] Sulfuric acid (60%), 200 ml;

[0027] Glacial acetic acid, 1000 ml;

[0028] Controlling parameters: temperature between 20-25° C., voltage being 30V, current being 0.5-2 A, time between 60-180 sec.

[0029] The titanium alloy electrolysis development mechanism: electrolysis and oxidation mechanism are controlled.

[0030] The electrolysis is determined by the size of the titanium alloy composition: Ti (electrolyzed)>Al>V.

[0031] The oxidation is determined by the activity of the titanium alloy components: Ti (oxidized)>Al>V.

[0032] In the embodiment of the present invention, the crystallographic orientation structured titanium alloy dental implant and manufacturing method thereof use titanium alloy electrolysis development technology to control the electrolysis and oxidation mechanism to form the [Ti/TiO.sub.2 anatase (215)] crystallographic orientation structure with specific crystal grains arrangement direction (crystallographic orientation). Such technique is applied in the osseointegration field for improving the activity of bone cells. The structure is relatively stable, uneasy to be worn and damage proof, not affected by the surface roughness, assures the hydrophilicity of the adherence capacity of osteocyte, and features a specific crystal grains arrangement direction (crystallographic orientation), so as to increase cell activity, hydrophilicity, and biocompatibility.

[0033] Following embodiments and comparative examples provide a person having ordinary skills in the field with a complete disclosure and description of articles, devices, and/or methods of making and evaluating the scope of the claims. Such contents are intended to be an illustration of the present invention and not intended to be used for limiting scope of the present invention.

Embodiment

[0034] The titanium alloy electrolysis development technology is applied. To control the electrolysis and oxidation mechanism to form a crystallographic orientation structure [Ti/TiO.sub.2 anatase (h,k,l)] sample, an electrolyte [200 ml of sulfuric acid (60%)+1000 ml of glacial acetic acid] with a 5 vol % water content is used. The titanium alloy sample is magnetically ground and pre-treated, including being cleansed, degreased with acetone organic solvent, acid pickled, and then electrolyzed with a 30V voltage, 0.5-2 A current for 60-180 seconds. During the electrolysis process, attention must be paid to the current conduction to prevent excessive electrolysis, failure of oxidation or excessive oxidation, and failure of electrolysis, which further cause failure of the grains arrangement of the electrolyzed titanium metal, resulting in poor metal grains arrangement, and generating electrolytic polishing mechanisms or anodic oxidation mechanism.

Comparative Example

[0035] Regarding the surface structure (Ti/TiO.sub.2, amorphous) of the commercially available brand of titanium alloy dental implant surface treatment technology, the sample uses anodic oxidation technology, which is a surface oxidation mechanism, and the electrolyte formula has 200 ml/L of sulfuric acid (60%), with the rest of the formula being water content. The sample is magnetically ground and pre-treated, including being cleansed, degreased with acetone organic solvent, acid pickled, and then anodic oxidized with a 30V voltage, 0.5-2 A current for 60-180 seconds.

[0036] Regarding the embodiment of the method of present invention and the comparative example, tests of HRXRD material analysis and the hydrophilicity and cell viability were carried out. The experimental results are discussed as follows.

[0037] 1. High Resolution X-Ray Diffraction (HRXRD): Low Grazing Angle Diffraction Analysis

[0038] As shown by HRXRD diffraction analysis results, the crystallographic orientation structure composition is [Ti/TiO.sub.2 anatase (h,k,l)] with a specific crystal grains arrangement direction (crystallographic orientation). The direction is the diffraction direction (hkl) of TiO.sub.2 anatase oxide layer structure, with a peak value of 20.

Embodiment

[0039] titanium alloy electrolysis development technology. The crystallographic orientation structure composition is [Ti/TiO.sub.2 anatase (215)], with a specific crystal grains arrangement direction (crystallographic orientation), wherein the direction is the diffraction direction of the TiO.sub.2 anatase oxide layer structure (215), with the diffraction peak of 20=75 degrees, as shown in FIG. 1.

Comparative Example

[0040] titanium alloy anodic technology. The structure is an amorphous (Ti/TiO.sub.2) structure, wherein the crystal grains are loose, without specific crystal grains arrangement direction, showing no TiO.sub.2 anatase diffraction direction and the peak value of 20, as shown in FIG. 2.

[0041] 2. Hydrophilicity and Cell Viability Test:

[0042] According to the results of the test data arranged from Table 1 and MTT cell survival rate analysis chart of FIG. 3, by comparing the [Ti/TiO.sub.2 anatase (215)] crystallographic orientation structure sample manufactured by the present invention with the amorphous surface structure (Ti/TiO.sub.2) sample of the commercially available brand of implant of the comparative example, the [Ti/TiO.sub.2 anatase (215)] crystallographic orientation structure has the highest light absorbance value, which means a higher cell activity and higher survival rate, lower contact angle, and more hydrophilic, so that it can accelerate the integration of active human bones, thereby confirming that the hydrophilicity and cell activity are related to the specific crystal grains arrangement direction (crystallographic orientation), and facilitates the promotion of osseointegration.

[0043] Table 1 shows the hydrophilicity and cell viability test data. The test is carried out by industry-university cooperation of the Department of Dentistry, China Medical University.

TABLE-US-00001 TABLE 1 Comparative Example amorphous surface structure (Ti/TiO.sub.2) Embodiment sample of the [Ti/TiO.sub.2 anatase commercially (215)] available brand of crystallographic implant orientation structure hydrophilicity 68.93 degrees 64.52 degrees test average contact angle cell viability 0.6565 0.709 test light absorbance

[0044] As shown by FIG. 4 and FIG. 5, the crystallographic orientation structured titanium alloy dental implant obtained by the aforementioned manufacturing method comprises a titanium alloy implant 10, with one end of the titanium alloy implant 10 having a thread portion 11, and the other end of the titanium alloy implant 10 having a fix portion 12; and a crystallographic orientation structure 13 formed on the titanium alloy implant through electrolysis and oxidation mechanisms. The crystallographic orientation structure 13 includes the deposition of an oxide layer structure with a specific crystal grains arrangement direction (crystallographic orientation), wherein the diffraction direction (215) measured through the HRXRD. Accordingly, the crystallographic orientation structured titanium alloy dental implant has the aforementioned effects.

[0045] The above-mentioned results of material analysis and experiments verify the embodiments of the present invention and comparative examples, thereby solving the above-mentioned problems. Therefore, the present invention is inventive.

[0046] Although particular embodiments of the invention have been described in detail for purposes of illustration, various modifications and enhancements may be made without departing from the spirit and scope of the invention. Accordingly, the invention is not to be limited except as by the appended claims.