OPTICAL COHERENCE TOMOGRAPHY DEVICE

Abstract

An optical coherence tomography device is provided with a split beam generating means which splits a beam emitted from a single light source into at least four split beams and outputs these, a measurement beam irradiating means which irradiates measurement beams onto different positions of a measurement target through a mechanism that can change the position of said measurement beams on the measurement target, a reference beam irradiating means which irradiates at least two of the at least four split beams that are not the measurement beams onto a reference beam mirror as reference beams, and an optical spectrum data generating means which acquires depth-direction structural data about the measurement target from interference light obtained by causing one of the reference beams reflected by the reference beam mirror to interfere with each of the measurement beams reflected or scattered by the measurement target.

Claims

1. An optical coherence tomography device comprising: a split beam generating unit that splits light emitted from a single light source into at least four split beams and outputting the split beams; a measurement beam irradiating unit that irradiates different positions of a measurement target with measurement beams being at least two of the at least four split beams through a mechanism capable of changing a position of each of the measurement beams on the measurement target; a reference beam irradiating unit that irradiates a reference beam mirror with at least two of the at least four split beams that are not the measurement beams, as reference beams; and an optical spectrum data generating unit that acquires depth-direction structural data about the measurement target from interference light to be acquired by causing one of the reference beams reflected by the reference beam mirror to interfere with each of the measurement beams reflected or scattered by the measurement target.

2. The optical coherence tomography device according to claim 1, wherein the measurement beam irradiating unit includes a front lens system being set in such a way that a plurality of measurement beams are collimated and cross at one point, an optical beam scanner being placed at a position in which the plurality of measurement beams cross, and a rear lens system that causes a plurality of measurement beams passing through the light beam scanner to be condensed on the measurement target, and changes, on the measurement target, a position of each of measurement beams constituted of the plurality of light beams with which different positions of the measurement target are irradiated.

3. The optical coherence tomography device according to claim 2, further comprising a mechanism for causing a lens of a rear lens system for the measurement beam irradiating unit to move in a direction parallel to a depth direction of the measurement target.

4. The optical coherence tomography device according to claim 2, wherein the measurement beam irradiating unit further includes a plurality of collimators that emit light propagating through a fiber to space, and an optical switch that selects the plurality of collimators through which the plurality of measurement beams pass and directs to the front lens system.

5. The optical coherence tomography device according to claim 4, wherein the plurality of collimators are arranged in such a way as to direct light propagating through the fiber to a different position in a radial direction of the front lens system.

6. The optical coherence tomography device according to claim 1, wherein the light source is a wavelength-swept laser light source, the optical spectrum data generating unit generates information on a change in an intensity ratio of the interference light, and the optical coherence tomography device further comprises a control unit that acquires depth-direction structural data about the measurement target, based on information on a change in an intensity ratio of the interference light to be generated by the optical spectrum data generating unit.

7. A method of generating an optical coherence tomographic image, comprising: splitting light emitted from a single light source into at least four split beams and outputting the split beams; irradiating different positions of a measurement target with measurement beams being at least two of the at least four split beams by adjusting a position of each of the measurement beams on the measurement target, and also irradiating a reference beam mirror with at least two of the at least four split beams that are not the measurement beams, as reference beams; and acquiring depth-direction structural data about the measurement target from interference light to be acquired by causing one of the reference beams reflected by the reference beam mirror to interfere with each of the measurement beams reflected or scattered by the measurement target.

8. The method of generating an optical coherence tomographic image according to claim 7, wherein an optical coherence tomography device includes a front lens system being set in such a way that a plurality of measurement beams are collimated and cross at one point, an optical beam scanner being placed at a position in which the plurality of measurement beams cross, and a rear lens system that causes a plurality of measurement beams passing through the light beam scanner to be condensed on the measurement target, and the method further comprises changing, on the measurement target, a position of each of measurement beams constituted of the plurality of light beams with which different positions of the measurement target are irradiated.

9. The method of generating an optical coherence tomographic image according to claim 8, further comprising adjusting a distance among irradiated positions on the measurement target with the plurality of measurement beams by causing a lens of a rear lens system in the optical coherence tomography device to move in a direction parallel to a depth direction of the measurement target.

10. The method of generating an optical coherence tomographic image according to claim 8, wherein the optical coherence tomography device further includes a plurality of collimators that emit light propagating through a fiber to space, and an optical switch that selects the plurality of collimators through which the plurality of measurement beams pass and directs to the front lens system.

11. The method of generating an optical coherence tomographic image according to claim 10, wherein the plurality of collimators are arranged in such a way as to direct light propagating through the fiber to a different position in a radial direction of the front lens system.

12. The method of generating an optical coherence tomographic image according to claim 10, further comprising adjusting a distance among irradiated positions on the measurement target with the plurality of measurement beams by the optical switch selecting the plurality of collimators.

13. The method of generating an optical coherence tomographic image according to claim 7, wherein the light source is a wavelength-swept laser light source, information on a change in an intensity ratio of the interference light is generated, and depth-direction structural data about the measurement target is acquired, based on the information on a change in an intensity ratio of the interference light.

Description

BRIEF DESCRIPTION OF DRAWINGS

[0030] FIG. 1 is a block diagram illustrating one example of an optical coherence tomography device according to an example embodiment of a superordinate concept of the disclosure.

[0031] FIG. 2 is a block diagram illustrating one example of an optical coherence tomography device according to an example embodiment.

[0032] FIG. 3 is a diagram illustrating one example of a configuration of an irradiation optical system in the optical coherence tomography device according to the example embodiment.

[0033] FIG. 4 is a diagram illustrating one example of an object light beam scanning pattern using the irradiation optical system in the optical coherence tomography device according to the example embodiment.

[0034] FIG. 5 is a diagram illustrating one example of the configuration of the irradiation optical system in the optical coherence tomography device according to the example embodiment.

[0035] FIG. 6 is a block diagram illustrating one example of an optical coherence tomography device according to another example embodiment.

[0036] FIG. 7 is a diagram illustrating one example of a related optical coherence tomography device.

EXAMPLE EMBODIMENT

[0037] Hereinafter, example embodiments are described with reference to the drawings.

[0038] Before describing a more specific example embodiment, an optical coherence tomography device according to an example embodiment of a superordinate concept of the disclosure is described. FIG. 1 is a block diagram illustrating one example of the optical coherence tomography device according to the example embodiment of the superordinate concept of the disclosure.

[0039] An optical coherence tomography device 60 in FIG. 1 includes an optical splitting device 61, a plurality of circulators 62, a plurality of splitting/combining devices 63, an irradiation optical system 64, a reference beam mirror 66, a plurality of balanced photodetectors 67, an optical spectrum data generating means 68, a control means 65, and the like.

[0040] The optical splitting device 61 splits light incident from a laser light source or the like into a plurality of light beams R01 and R02. The plurality of light beams R01 and R02 are split into object light beams R11 and R12 and reference beams R21 and R22 by the plurality of splitting/combining devices 63 via the plurality of circulators 62.

[0041] The plurality of object light beams R11 and R12 being output from each of the splitting/combining devices 63 pass through the irradiation optical system 64, and a measurement target is irradiated with the plurality of object light beams R11 and R12 and scanned. More specifically, the irradiation optical system 64 irradiates different positions on one plane of the measurement target with each of a plurality of object light beams 69a and 69b, and scans a certain range. Herein, the irradiation optical system 64 is provided with a mechanism for controlling a distance between the object light beam 69a and the object light beam 69b.

[0042] The control means 65 controls the irradiation optical system 64 in such a way as to irradiate the different positions on one plane of the measurement target with each of the plurality of object light beams R11 and R12. Preferably, the control means 65 controls a period and a speed for scanning the measurement target by the irradiation optical system 64.

[0043] The plurality of reference beams R21 and R22 being output from each of the splitting/combining devices 63 are reflected by the reference beam mirror 66, and return to the splitting/combining devices 63.

[0044] In the splitting/combining device 63, an object light beam R31 to be scattered from the measurement target and a reference beam R41 to be reflected from the reference beam mirror 66 interfere with each other, and an interference light R51 and an interference light R61 are acquired. Similarly, in the splitting/combining device 63, an object light beam R32 to be scattered from the measurement target and a reference beam R42 to be reflected from the reference beam mirror 66 interfere with each other, and an interference light R52 and an interference light R62 are acquired.

[0045] The interference light R51 and R52 are input to the associated each of balanced photodetectors 67 via the circulators 62, and the interference light R61 and R62 are directly input to the associated each of balanced photodetectors 67. Information on a change in an intensity ratio between the interference light R51 and the interference light R61 and information on a change in an intensity ratio between the interference light R52 and the interference light R62 are each input, from each of the balanced photodetectors 67, to the optical spectrum data generating means 68.

[0046] The optical spectrum data generating means 68 generates an interference light spectrum, based on information on a wavelength change in the light incident to the optical splitting device 61 and the information on the change in the intensity ratio between the interference light R51 and R61. Similarly, the optical spectrum data generating means 68 generates the interference light spectrum, based on the information on the wavelength change in the light incident to the optical splitting device 61 and the information on the change in the intensity ratio between the interference light R52 and R62. Further, the optical spectrum data generating means 68 connects the generated interference light spectra and generates interference light spectrum data related to the measurement target.

[0047] According to the optical coherence tomography device 60 in FIG. 1, the light emitted from the laser light source or the like is split into the plurality of light beams R01 and R02 by the optical splitting device 61. Each of the light beams R01 and R02 is split into the plurality of measurement beams R11 and R12 and the plurality of reference beams R21 and R22 by the plurality of splitting/combining devices 63. The plurality of measurement beams R11 and R12 are directed to different measurement positions of the measurement target by the irradiation optical system 64. The scattered beams to be generated at each of the measurement positions are directed to each of the splitting/combining devices 63 again via the irradiation optical system 64, and are combined with the reference beams at each of the splitting/combining devices 63, and thus the interference light R51, R52, R61, and R62 are generated. The plurality of reference beams R21 and R22 to be split by each of the splitting/combining devices 63 are reflected by the reference beam mirror 66, and return to each of the splitting/combining devices 63. The interference light R51 and R52 to be generated by each of the splitting/combining devices 63 are incident to the balanced photodetectors 67 via the circulators 62, the interference light R61 and R62 are directly incident to the balanced photodetectors 67, a plurality of synthesized light beams are each spectroscopically measured, a signal processing step of performing Fourier transform processing or the like is performed, and thus the interference light spectrum data related to the measurement target is generated.

[0048] Further, according to the optical coherence tomography device 60 in FIG. 1, the distance between the plurality of object light beams 69a and 69b from the irradiation optical system 64 to the measurement target is controlled and the distance between the positions for irradiation to the measurement target with the plurality of object light beams 69a and 69b is changeable, and thus the both functions of wide range measurement and flow part discrimination measurement can be provided. Hereinafter, a more specific example embodiment is described.

[0049] FIG. 2 is a block diagram illustrating one example of an optical coherence tomography device 100 according to one example embodiment.

[0050] As illustrated in FIG. 2, the optical coherence tomography device 100 includes a wavelength-swept laser light source 101, an optical splitting device 111, a delay device 112, a plurality of circulators 103, a plurality of beam splitting/combining devices 104, a plurality of fiber collimators 105, an irradiation optical system 106, a reference beam mirror 108, a plurality of balanced photodetectors 102, an optical spectrum data generating unit 109 as one example of optical spectrum data generating means, a control unit 110 as one example of control means, and the like. FIG. 2 illustrates a case where the number of the circulators 103 is 2, the number of the beam splitting/combining devices 104 is 2, the number of the fiber collimators 105 is 2, and the number of the balanced photodetectors 102 is 2 provided in the optical coherence tomography device 100. However, the number of the circulators 103, the number of the beam splitting/combining devices 104, the number of the fiber collimators 105, and the number of the balanced photodetectors 102 provided in the optical coherence tomography device 100 according to the one example embodiment may be determined depending on the number of which light beams emitted from the wavelength-swept laser light source 101 are split in the optical splitting device 111, and are not limited to the numbers illustrated in the drawing.

[0051] The wavelength-swept laser light source 101 generates a wavelength-swept optical pulse. Specifically, the wavelength-swept laser light source 101 generates an optical pulse of which a wavelength increases from 1250 nm to 1350 nm over a duration of 10 μs. Further, the wavelength-swept laser light source 101 repeatedly generates the optical pulse at a frequency of 50 kHz every 20 μs. One example of a wavelength-swept laser light source to be used for SS-OCT is described in Patent Literature 5 (PTL5).

[0052] The light emitted from the wavelength-swept laser light source 101 is split into a plurality of light beams R01 and R02 by the optical splitting device 111, and the plurality of light beams R01 and R02 pass through the plurality of circulators 103 and are split into object light beams R11 and R12 and reference beams R21 and R22 by the plurality of beam splitting/combining devices 104. As the beam splitting/combining device 104, a device using fiber fusion, a device using microoptics, or the like can be used. Note that, the delay device 112 provides a time delay to the light beam R02 with the light beam R01 as a reference. For example, in the delay device 112, a time delay of 3ns is added to the light beam R02.

[0053] The plurality of object light beams R11 and R12 to be output from the beam splitting/combining devices 104 pass through the fiber collimators 105 and the irradiation optical system 106, and a measurement target 120 is irradiated with the plurality of object light beams R11 and R12 and scanned. More specifically, the irradiation optical system 106 irradiates different positions on an X-Y plane of the measurement target 120 with a plurality of object light beams 107a and 107b and scan a certain range. The irradiation optical system 106 is provided with a mechanism for controlling a distance between the object light beam 107a and the object light beam 107b.

[0054] The object light beams 107a and 107b with which irradiate the measurement target 120 are scattered backward (in a direction opposite to the irradiation direction of the object light beam) from the measurement target 120. Then, object light beams (backscattered beams) R31 and R32 to be scattered from the measurement target 120 pass through the irradiation optical system 106 and the fiber collimators 105, and return to the beam splitting/combining devices 104.

[0055] The plurality of reference beams R21 and R22 to be output from each of the beam splitting/combining devices 104 are reflected by the reference beam mirror 108 and return to the beam splitting/combining devices 104.

[0056] Therefore, in the beam splitting/combining device 104, the object light beam R31 to be scattered from the measurement target 120 and a reference beam R41 to be reflected from the reference beam mirror 108 interfere with each other, thereby acquiring interference light R51 and interference light R61. Similarly, in the beam splitting/combining device 104, the object light beam R32 to be scattered from the measurement target 120 and a reference beam R42 to be reflected from the reference beam mirror 108 interfere with each other, thereby acquiring interference light

[0057] R52 and interference light R62. Therefore, an intensity ratio between the interference light R51 and R52 and the interference light R61 and R62 is determined by a phase difference between the object light beams R31 and R32 and the reference beams R41 and R42.

[0058] The interference light R51 and R52 are input to the associated each of balanced photodetectors 102 via the circulators 103, and the interference light R61 and R62 are directly input to the associated each of balanced photodetectors 102. Then, information on a change in an intensity ratio between the interference light R51 and the interference light

[0059] R61 and information on a change in an intensity ratio between the interference light R52 and the interference light R62 are each input, from each of the balanced photodetectors 102, to the optical spectrum data generating unit 109.

[0060] Note that, the balanced photodetector 102 is a photodetector in which two photo diodes are connected in series and the connection is an output (differential output). A frequency band of the balanced photodetector 102 is equal to or less than 1 GHz.

[0061] Further, optical path length of the object light beam and optical path length of the reference beam from when the object light beam R11 and the reference beam R21 are split by the beam splitting/combining device 104 until the backscattered beam R31 of the object light beam and the returned light beam R41 of the reference beam are combined again are approximately equal. When the optical path length greatly differs between the object light beam and the reference beam, a frequency difference (wavelength difference) between the object light beam R31 and the reference beam R41 that interfere with each other in the beam splitting/combining device 104 becomes larger than the frequency band of the balanced photodetector 102, and it becomes difficult to detect the intensity ratio between the interference light R51 and the interference light R61 that reflects a phase difference between the object light beam R31 and the reference beam R41. Further, optical path length of the object light beam and optical path length of the reference beam from when the object light beam R12 and the reference beam R22 are split by the beam splitting/combining device 104 until the backscattered beam R32 of the object light beam and the returned light beam R42 of the reference beam are combined again are approximately equal. When the optical path length greatly differs between the object light beam and the reference beam, a frequency difference (wavelength difference) between the object light beam R32 and the reference beam R42 that interfere with each other in the beam splitting/combining device 104 becomes larger than the frequency band of the balanced photodetector 102, and it becomes difficult to detect the intensity ratio between the interference light R51 and the interference light R61 that reflects a phase difference between the object light beam R31 and the reference beam R41.

[0062] The optical spectrum data generating unit 109 generates interference light spectrum data, based on information on a wavelength change in the light emitted from the wavelength-swept laser light source 101 and the information on the change in the intensity ratio between the interference light R51 and R61. Similarly, the optical spectrum data generating unit 109 generates the interference light spectrum data, based on the information on the wavelength change in the light emitted from the wavelength-swept laser light source 101 and the information on the change in the intensity ratio between the interference light R52 and R62. Further, the optical spectrum data generating unit 109 inputs the generated interference light spectrum data to the control unit 110.

[0063] The control unit 110 controls each unit of the optical coherence tomography device 100.

[0064] The control unit 110 controls the irradiation optical system 106 in such a way as to irradiate different positions on the X-Y plane of the measurement target 120 with each of the plurality of object light beams R11 and R12.

[0065] Further, the control unit 110 controls a period and a speed for scanning the measurement target 120 by the irradiation optical system 106.

[0066] Further, the control unit 110 applies Fourier transform to the interference light spectrum to be generated by the optical spectrum data generating unit 109, and acquires data indicating the intensity of a backscattered beam (object light beam) at a different position in a depth direction (Z direction) of the measurement target 120 (A-scan). More specifically, the interference light spectrum of a center wavelength λ0 and the number of sample points N in a wavelength range Δλ is acquired by A-scan, and the control unit 110 applies discrete Fourier transform to the interference light spectrum, thereby acquiring the depth-direction structural data of which unit of length is λ0.sup.2/Δλ.

[0067] Further, the control unit 110 generates two-dimensional tomographic structural data by connecting measurement results acquired by repeating the A-scan operation while the irradiation positions with the object light beams R11 and R12 are moved in a scanning line direction (B-scan). Herein, the scanning line direction is at least either of the X and the Y directions.

[0068] Further, the control unit 110 generates three-dimensional tomographic structural data in X, Y, and Z directions by connecting measurement results acquired by repeating the B-scan operation while the irradiation positions with the object light beams R11 and R12 are moved in the scanning line direction and the direction perpendicular to the scanning line (C-scan).

[0069] Further, the control unit 110 performs, when the optical coherence tomography device operates in such a way as to measure a wide range at high speed, processing of connecting a plurality of 3D structural data (three-dimensional structural data) acquired by scanning the plurality of object light beams.

[0070] Further, the control unit 110 performs, when the optical coherence tomography device operates in such a way as to detect a flow part, comparison analysis of 3D structural data acquired at a same place at different times by scanning the plurality of object light beams.

[0071] FIG. 3 is a diagram illustrating one example of a configuration of an irradiation optical system that irradiates a measurement target with a plurality of object light beams. The irradiation optical system in FIG. 3 includes a lens 202 as one example of a front lens system, a galvano scanner 206, two lenses 203 and 204 as one example of a rear lens system, a galvano scanner control unit, and a lens control unit. Object light beams propagating from a plurality of beam splitting/combining devices through fibers are emitted from a plurality of fiber collimators 201, pass through the lens 202 and become collimated light beams, and cross after propagating a certain distance. The galvano scanner 206 is set at a point where the object light beams cross, thereby enabling scanning of the object light beams. The galvano scanner 206 is controlled by a galvano scanner controller 207 as one example of the galvano scanner control unit. Further, the plurality of object light beams pass through the two lenses 203 and 204 and are each condensed on points that are separated by a certain distance near a surface of a measurement target 210. Lens positions of the two lenses 203 and 204 are controlled by a lens controller 205 as one example of the lens control unit along a direction parallel to the above Z direction of the measurement target 120.

[0072] When a distance between the two lenses 203 and 204 is short, distant positions on the measurement target are irradiated with the plurality of object light beams as a state A illustrated in FIG. 3. When the distance between the two lenses 203 and 204 is long, close positions on the measurement target are irradiated with the plurality of object light beams as a state B illustrated in FIG. 3.

[0073] FIG. 4 is a diagram illustrating an example of a scanning pattern of the object light beam using the irradiation optical system.

[0074] Scanning A in FIG. 4 or scanning B in FIG. 4 illustrates an example of a scanning pattern of which distant positions on the measurement target are irradiated with the plurality of object light beams, and the object light beams are scanned, thereby measuring a wide range at high speed. In the scanning A of FIG. 4, initial positions of irradiation points with two object light beams on the measurement target are 301 and 302, and scanning are performed at high speed in the X direction by the control of the galvano scanner as illustrated. In the scanning B of FIG. 4, initial positions of irradiation points with the two object light beams on the measurement target are 303 and 304, and the scanning are performed by the control of the galvano scanner as illustrated. In both cases, the plurality of object light beams are scanned simultaneously over different areas, thereby enabling measuring a wide range at high speed.

[0075] Scanning C in FIG. 4 or scanning D in FIG. 4 illustrates an example of a scanning pattern of which close positions on the measurement target are irradiated with the plurality of object light beams, and the object light beams are scanned, thereby measuring a wide range at high speed. In the scanning C of FIG. 4, initial positions of irradiation points with two object light beams on the measurement target are 305 and 306, and scanning are performed at high speed in the X direction by the control of the galvano scanner as illustrated. In the scanning D of FIG. 4, initial positions of irradiation points with the two object light beams on the measurement target are 307 and 308, and the scanning are performed by the control of the galvano scanner as illustrated. In both cases, the plurality of object light beams are scanned at a same place multiple times in a short time, thereby enabling discrimination of a flow part.

[0076] FIG. 5 is a diagram illustrating another example of a configuration of the irradiation optical system that irradiates the measurement target with the plurality of object light beams. The irradiation optical system in FIG. 5 includes fiber collimators 401, 402, 403, and 404, a lens 405 as one example of the front lens system, a galvano scanner 407, a lens 406 as one example of the rear lens system, a galvano scanner controller 408, and optical switches 410 and 412. A plurality of fibers 409 and 411 that propagate the object light beams from the plurality of beam splitting/combining devices are each connected to the optical switches 410 and 412. The fiber collimators 401 and 402 are arranged in such a way as to direct light propagating through the fiber 409 to different positions in a radial direction of the lens 405. Similarly, the fiber collimators 404 and 403 are arranged in such a way as to direct light propagating through the fiber 411 to different positions in the radial direction of the lens 405. The optical switch 410 selects whether the object light beam propagating through the fiber 409 is passed through the fiber collimator 401 or the fiber collimator 402. The optical switch 412 selects whether the object light beam propagating through the fiber 411 is passed through the fiber collimator 403 or the fiber collimator 404. The plurality of object light beams to be emitted from the plurality of fiber collimators pass through the lens 405 and become collimated light beams, and cross after propagating a certain distance. The galvano scanner 407 is set at a point where the object light beams cross, thereby enabling scanning of the object light beams. The galvano scanner 407 is controlled by the galvano scanner controller 408 as one example of the galvano scanner control unit. Further, the plurality of object light beams pass through the lens 406 and are each condensed on points that are separated by a certain distance near a surface of a measurement target 420.

[0077] When 401 and 404 are selected as a fiber collimator for object light beam emission using the optical switches 410 and 412, distant positions on the measurement target are irradiated with the plurality of object light beams as a state A illustrated in FIG. 5. When 402 and 403 are selected as the fiber collimator for object light beam emission using the optical switches 410 and 412, close positions on the measurement target are irradiated with the plurality of object light beams as a state B illustrated in FIG. 5.

[0078] According to the optical coherence tomography device 100 according to the above-described one example embodiment, the distance between the plurality of object light beams 107a and 107b from the irradiation optical system 106 to the measurement target 120 is controlled and the distance between the positions for irradiation to the measurement target with the plurality of object light beams 107a and 107b is changeable, and thus the both functions of wide range measurement and flow part discrimination measurement can be provided.

[0079] In other words, the wide range measurement at high speed can be achieved by configuring in such a way as to control the distance between the plurality of object light beams 107a and 107b from the irradiation optical system 106 to the measurement target 120 and simultaneously irradiate distant positions on the measurement target 120 with light beams. Further, the flow part discrimination measurement can be achieved by configuring in such a way as to control the distance between the plurality of object light beams 107a and 107b from the irradiation optical system 106 to the measurement target 120 and irradiate a same place with light beams multiple times in a short time.

[0080] As described above, the number of the circulators 103, the number of the beam splitting/combining devices 104, the number of the fiber collimators 105, and the number of the balanced photodetectors 102 provided in the optical coherence tomography device 100 according to the one example embodiment may be determined depending on the number of which light beams emitted from the wavelength-swept laser light source 101 are split in the optical splitting device 111, and are not limited to the numbers illustrated in FIG. 2.

[0081] FIG. 6 is a block diagram illustrating an optical coherence tomography device 100a according to another example embodiment. The optical coherence tomography device 100a illustrated in FIG. 6 includes a wavelength-swept laser light source 101a, an optical splitting device 111a, delay devices 112a and 112b, a plurality of circulators 103a, a plurality of beam splitting/combining devices 104a, a plurality of fiber collimators 105a, an irradiation optical system 106a, a reference beam mirror 108a, a plurality of balanced photodetectors 102a, an optical spectrum data generating unit 109a as one example of optical spectrum data generating means, a control unit 110a as one example of control means, and the like. FIG. 6 illustrates a case where the number of the circulators 103a is 3, the number of the beam splitting/combining devices 104a is 3, the number of the fiber collimators 105a is 3, and the number of the balanced photodetectors 102a is 3 provided in the optical coherence tomography device 100a. Note that, the delay devices 112a and 112b provide a time delay for light beams R02 and R03 with the light beam R01 as a reference. For example, a time delay of 3ns is added in the delay device 112a and a time delay of 6ns is added in the delay device 112b.

[0082] The control unit 110a in FIG. 6 controls each unit of the optical coherence tomography device 100a, similarly to the control unit 110 in FIG .2. The control unit 110a in FIG. 6 controls the irradiation optical system 106a in such a way as to irradiate different positions on a X-Y plane of a measurement target 120 with each of a plurality of object light beams R11, R12, and R13. Further, the control unit 110a in FIG. 6 controls a period and a speed for scanning the measurement target 120 by the irradiation optical system 106a.

[0083] Further, the control unit 110a in FIG. 6 applies Fourier transform to an interference light spectrum to be generated by the optical spectrum data generating unit 109a, and acquires data indicating an intensity of a backscattered beam (object light beam) at a different position in a depth direction (Z direction) of the measurement target 120 (A-scan).

[0084] Further, the control unit 110a in FIG. 6 generates two-dimensional tomographic structural data by connecting measurement results acquired by repeating the A-scan operation while irradiation positions with the object light beams R11, R12 and R13 are moved in a scanning line direction (B-scan).

[0085] Further, the control unit 110 generates three-dimensional tomographic structural data in X, Y, and Z directions by connecting measurement results acquired by repeating the B-scan operation while the irradiation positions with the object light beams R11 and R12 are moved in the scanning line direction and a direction perpendicular to the scanning line (C-scan).

[0086] Further, the control unit 110a in FIG. 6 performs, when the optical coherence tomography device 100a operates in such a way as to measure a wide range at high speed, processing of connecting a plurality of 3D structural data (three-dimensional structural data) acquired by scanning the plurality of object light beams.

[0087] Further, the control unit 110 in FIG. 6 performs, when the optical coherence tomography device 100a operates in such a way as to detect a flow part, comparison analysis of 3D structural data acquired at a same place at different times by scanning the plurality of object light beams.

[0088] According to the optical coherence tomography device 100a illustrated in FIG. 6, in the beam splitting/combining device 104a, an object light beam R31 to be scattered from the measurement target 120 and a reference beam R41 to be reflected from the reference beam mirror 108a interfere with each other, thereby acquiring interference light R51 and interference light R61. Similarly, in the beam splitting/combining device 104a, an object light beam R32 to be scattered from the measurement target 120 and a reference beam R42 to be reflected from the reference beam mirror 108a interfere with each other, thereby acquiring interference light R52 and interference light R62. Similarly, in the beam splitting/combining device 104a, an object light beam R33 to be scattered from the measurement target 120 and a reference beam R43 to be reflected from the reference beam mirror 108a interfere with each other, thereby acquiring interference light R53 and interference light R63. Therefore, an intensity ratio between the interference light R51, R52, and R53 and the interference light R61, R62, and R63 is determined by a phase difference between the object light beams R31, R32, and R33 and the reference beams R41, R42, and R43.

[0089] The interference light R51, R52, and R53 are input to the associated each of balanced photodetectors 102a via the circulators 103a, and the interference light R61, R62, and R63 are directly input to the associated each of balanced photodetectors 102a. Then, information on a change in the intensity ratio between the interference light R51 and the interference light R61, information on a change in the intensity ratio between the interference light R52 and the interference light R62, and information on a change in the intensity ratio between the interference light R53 and the interference light R63 are each input, from each of the balanced photodetectors 102a, to the optical spectrum data generating unit 109a.

[0090] In the optical coherence tomography device 100a illustrated in FIG. 6, similarly to the optical coherence tomography device 100 according to the one example embodiment, a distance among the positions for irradiation to the measurement target 120 with the plurality of object light beams is changeable, and thus, the both functions of wide range measurement and flow part discrimination measurement can be provided with minimal configuration modification.

[0091] In other words, the wide range measurement at high speed can be achieved by configuring in such a way as to control the distance among the plurality of object light beams 107a, 107b, and 107c from the irradiation optical system 106a to the measurement target 120 and simultaneously irradiate distant positions on the measurement target 120 with light beams. Further, the flow part discrimination measurement can be achieved by configuring in such a way as to control the distance among the plurality of object light beams 107a, 107b, and 107c from the irradiation optical system 106 to the measurement target 120 and irradiate a same place with light beams multiple times in a short time.

[0092] The above-described one example embodiment can be summarized as follows. In an optical coherence tomography device, irradiation with a plurality of object light beams is useful for performing wide range measurement at high speed or performing measurement for discriminating a flow part such as blood flow, however the use of another device for performing both of the measurement results in an increase in size and cost.

[0093] In the optical coherence tomography device 100 according to the above-described one example embodiment, the wavelength-swept laser light source 101 generates a wavelength-swept optical pulse. Light emitted from the wavelength-swept laser light source 101 is split into a plurality of light beams by the optical splitting device 111, and the plurality of light beams are split into an object light beam and a reference beam by the each of beam splitting/combining devices 104. The plurality of object light beams pass through the fiber collimator 105 and the irradiation optical system 106 constituted of a scan mirror and a lens, the measurement target 120 is irradiated with the plurality of object light beams as the object light beams 107a and 107b, and backscattered beams return to each of the beam splitting/combining devices 104. On the other hand, the reference beam returns to the beam splitting/combining device 104 via the reference beam mirror 108. Thus, interference between the object light beam and the reference beam occurs, a measurement value of interference light intensity is acquired by photoelectric conversion in the balanced photodetector 102 with two optical input ports, and 3D structural data (three-dimensional structural data) is calculated in the control unit 110.

[0094] Herein, in the optical coherence tomography device 100 according to the one example embodiment, the irradiation optical system that changes a distance between the object light beams 107a and 107b is used. When wide range measurement at high speed is performed, distant positions on the measurement target are irradiated with the plurality of object light beams. In this case, wide range structural data are acquired by connecting pieces of structural data being acquired by simultaneously scanning different area. When the measurement for discriminating a flow part such as blood flow is performed, close positions on the measurement target are irradiated with the plurality of object light beams and are scanned in such a way as to irradiate a same place multiple times in a short time. In this case, a flow part is detected from the structural data acquired at the same place at different times.

[0095] Therefore, in the optical coherence tomography device 100 according to the one example embodiment, the irradiation optical system includes a mechanism for changing, on the measurement target, positions of the object light beams 107a and 107b with which irradiate different positions on the measurement target, and thus, the both functions of wide range measurement and flow part discrimination measurement can be provided with minimal configuration modification.

[0096] The whole or part of the example embodiments disclosed above can be described as, but not limited to, the following supplementary notes.

(Supplementary Note 1)

[0097] An optical coherence tomography device including:

[0098] a split beam generating means for splitting light emitted from a single light source into at least four split beams and outputting the split beams;

[0099] a measurement beam irradiating means for irradiating different positions of a measurement target with measurement beams being at least two of the at least four split beams through a mechanism capable of changing a position of each of the measurement beams on the measurement target;

[0100] a reference beam irradiating means for irradiating a reference beam mirror with at least two of the at least four split beams that are not the measurement beams, as reference beams; and

[0101] an optical spectrum data generating means for acquiring depth-direction structural data about the measurement target from interference light to be acquired by causing one of the reference beams reflected by the reference beam mirror to interfere with each of the measurement beams reflected or scattered by the measurement target.

(Supplementary Note 2)

[0102] The optical coherence tomography device according to supplementary note 1, wherein

[0103] the measurement beam irradiating means includes [0104] a front lens system being set in such a way that a plurality of measurement beams are collimated and cross at one point, [0105] an optical beam scanner being placed at a position in which the plurality of measurement beams cross, and [0106] a rear lens system that causes a plurality of measurement beams passing through the light beam scanner to be condensed on the measurement target, and [0107] changes, on the measurement target, a position of each of measurement beams constituted of the plurality of light beams with which different positions of the measurement target are irradiated.

(Supplementary Note 3)

[0108] The optical coherence tomography device according to supplementary note 2, further including

[0109] a mechanism for causing a lens of a rear lens system for the measurement beam irradiating means to move in a direction parallel to a depth direction of the measurement target.

(Supplementary Note 4)

[0110] The optical coherence tomography device according to supplementary note 2, wherein

[0111] the measurement beam irradiating means further includes [0112] a plurality of collimators that emit light propagating through a fiber to space, and [0113] an optical switch that selects the plurality of collimators through which the plurality of measurement beams pass and directs to the front lens system.

(Supplementary Note 5)

[0114] The optical coherence tomography device according to supplementary note 4, wherein

[0115] the plurality of collimators are arranged in such a way as to direct light propagating through the fiber to a different position in a radial direction of the front lens system.

(Supplementary Note 6)

[0116] The optical coherence tomography device according to any one of supplementary notes 1 to 5, wherein

[0117] the light source is a wavelength-swept laser light source;

[0118] the optical spectrum data generating means generates information on a change in an intensity ratio of the interference light; and the optical coherence tomography device further includes a control means for acquiring depth-direction structural data about the measurement target, based on information on a change in an intensity ratio of the interference light to be generated by the optical spectrum data generating means.

(Supplementary Note 7)

[0119] A method of generating an optical coherence tomographic image, including:

[0120] splitting light emitted from a single light source into at least four split beams and outputting the split beams;

[0121] irradiating different positions of a measurement target with measurement beams being at least two of the at least four split beams by adjusting a position of each of the measurement beams on the measurement target, and also irradiating a reference beam mirror with at least two of the at least four split beams that are not the measurement beams, as reference beams; and

[0122] acquiring depth-direction structural data about the measurement target from interference light to be acquired by causing one of the reference beams reflected by the reference beam mirror to interfere with each of the measurement beams reflected or scattered by the measurement target.

(Supplementary Note 8 )

[0123] The method of generating an optical coherence tomographic image according to supplementary note 7, wherein

[0124] an optical coherence tomography device includes [0125] a front lens system being set in such a way that a plurality of measurement beams are collimated and cross at one point, [0126] an optical beam scanner being placed at a position in which the plurality of measurement beams cross, and [0127] a rear lens system that causes a plurality of measurement beams passing through the light beam scanner to be condensed on the measurement target, and

[0128] the method further includes changing, on the measurement target, a position of each of measurement beams constituted of the plurality of light beams with which different positions of the measurement target are irradiated.

(Supplementary Note 9)

[0129] The method of generating an optical coherence tomographic image according to supplementary note 8, further including

[0130] adjusting a distance among irradiated positions on the measurement target with the plurality of measurement beams by causing a lens of a rear lens system in the optical coherence tomography device to move in a direction parallel to a depth direction of the measurement target.

(Supplementary Note 10)

[0131] The method of generating an optical coherence tomographic image according to supplementary note 8, wherein

[0132] the optical coherence tomography device further includes [0133] a plurality of collimators that emit light propagating through a fiber to space, and [0134] an optical switch that selects the plurality of collimators through which the plurality of measurement beams pass and directs to the front lens system.

(Supplementary Note 11)

[0135] The method of generating an optical coherence tomographic image according to supplementary note 10, wherein

[0136] the plurality of collimators are arranged in such a way as to direct light propagating through the fiber to a different position in a radial direction of the front lens system.

(Supplementary Note 12)

[0137] The method of generating an optical coherence tomographic image according to supplementary note 10 or 11, further including adjusting a distance among irradiated positions on the measurement target with the plurality of measurement beams by the optical switch selecting the plurality of collimators.

(Supplementary Note 13)

[0138] The method of generating an optical coherence tomographic image according to any one of supplementary notes 7 to 12, wherein

[0139] the light source is a wavelength-swept laser light source,

[0140] an optical spectrum data generating means generates information on a change in an intensity ratio of the interference light, and [0141] the method further includes a control means for acquiring depth-direction structural data about the measurement target, based on information on a change in an intensity ratio of the interference light to be generated by the optical spectrum data generating means.

[0142] While the disclosure has been particularly shown and described with reference to example embodiments thereof, the disclosure is not limited to these example embodiments. It will be understood by those of ordinary skill in the art that various changes in form and details may be made therein without departing from the spirit and scope of the disclosure as defined by the claims.

REFERENCE SIGNS LIST

[0143] 100 Optical coherence tomography device

[0144] 101 Wavelength-swept laser light source

[0145] 102 Balanced photodetector

[0146] 103 Circulator

[0147] 104 Beam splitting/combining device

[0148] 105 Fiber collimator

[0149] 106 Irradiation optical system constituted of scan mirror and lens

[0150] 107 Object light beam

[0151] 108 Reference beam mirror

[0152] 109 Optical spectrum data generating unit

[0153] 110 Control unit

[0154] 111 Optical splitting device

[0155] 112 Delay device

[0156] 120 Measurement target

[0157] 201 Fiber collimator

[0158] 202 to 204 Lens

[0159] 205 Lens controller

[0160] 206 Galvano scanner

[0161] 207 Galvano scanner controller

[0162] 210 Measurement target

[0163] 401 to 404 Fiber collimator

[0164] 405 to 406 Lens

[0165] 407 Galvano scanner

[0166] 408 Galvano scanner controller

[0167] 410, 412 Optical switch

[0168] 420 Measurement target

OPTICAL COHERENCE TOMOGRAPHY DEVICE

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G01B2290/65

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G02B27/14

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A61B5/1172

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G01B9/02019

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G01B9/02091

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G01B9/02004

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G02B6/262

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G01B9/02027

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G02B27/108

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G01B9/02077

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G06V40/1382

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A61B5/0066

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G01B9/02

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G02B27/10

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G02B27/14

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Abstract

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Description