Hemostatic compound and preparation method thereof

Abstract

A hemostatic compound is provided. The hemostatic compound comprises molecular sieves and a fiber. The molecular sieves are independently dispersed on a fiber surface of the fiber without agglomeration and directly contact the fiber surface. A first surface of the molecular sieve contacted with the fiber is defined as an inner surface, and a second surface of the molecular sieve uncontacted with the fiber is defined as an outer surface. The molecular sieve forms a growth-matched coupling with the fiber on the inner surface, and the growth-matched coupling refers to that a plurality of molecular sieve microparticles grow to match the fiber surface to form a tightly-coupled coupling interface that matches the fiber surface.

Claims

1. A hemostatic compound, comprising molecular sieves and a fiber, wherein the molecular sieves are independently dispersed on a fiber surface of the fiber without agglomeration; when randomly taking n samples of the hemostatic compound at different locations and analyzing a content of the molecular sieves on the fiber surface, a coefficient of variation of the content of the molecular sieves in the n samples is ≤15%; wherein n is a positive integer greater than or equal to 8; the molecular sieves directly contact the fiber surface; a first surface of the molecular sieve contacted with the fiber is defined as an inner surface, and a second surface of the molecular sieve uncontacted with the fiber is defined as an outer surface; wherein the inner surface is a rough and planer surface matched with the fiber surface; the molecular sieve forms a growth-matched coupling with the fiber on the inner surface, and the growth-matched coupling refers to that a plurality of molecular sieve microparticles grow to match the fiber surface to form a tightly-coupled coupling interface that matches the fiber surface; a first particle size D90 of the molecular sieve microparticles is 0.01 to 50 μm, a second particle size D50 of the molecular sieve microparticles is 0.005 to 30 μm; both the inner surface and the outer surface are composed of molecular sieve nanoparticles; the first particle size D90 refers to a particle size corresponding to a cumulative particle size distribution percentage of the molecular sieve microparticles on the surface of the hemostatic compound reaching 90%; the second particle size D50 refers to a particle size corresponding to a cumulative particle size distribution percentage of the molecular sieve microparticles on the surface of the hemostatic compound reaching 50% wherein the molecular sieve is selected from the group consisting of X-type zeolite molecular sieve, Y-type zeolite molecular sieve, A-type zeolite molecular sieve, ZSM-5 (Zeolite Socony Mobil-5) molecular sieve, chabazite, β-zeolite molecular sieve, mordenite, L-type zeolite molecular sieve, P-type zeolite molecular sieve, merlinoite, AlPO.sub.4-5 (Aluminophosphate) molecular sieve, AlPO.sub.4-11 molecular sieve, SAPO-31 (Silicoaluminophosphate) molecular sieve, SAPO-34 molecular sieve, SAPO-11 molecular sieve, BAC-1 (Boron-Aluminum OxO-Chloride) molecular sieve, BAC-3 molecular sieve, BAC-10 molecular sieve, and combination thereof, and wherein the fiber is selected from of the group consisting of silk fiber, chitin fiber, rayon fiber, acetate fiber, carboxymethyl cellulose, bamboo fiber, cotton fiber, linen fiber, wool, wood fiber, lactide polymer fiber, glycolide polymer fiber, polyester fiber, polyamide fiber, polypropylene fiber, polyethylene fiber, polyvinyl chloride fiber, polyacrylonitrile fiber, viscose fiber, and combination thereof.

2. The hemostatic compound of claim 1, wherein the inner surface is the planar surface matched with the fiber surface and the outer surface is a non-planar surface.

3. The hemostatic compound of claim 1, wherein each of the molecular sieves independently dispersed on the fiber surface has a boundary.

4. The hemostatic compound of claim 1, wherein the average size of the molecular sieve nanoparticles of the outer surface is larger than the average size of the molecular sieve nanoparticles of the inner surface.

5. The hemostatic compound of claim 1, wherein the average size of the molecular sieve nanoparticles of the inner surface is 2 to 100 nm.

6. The hemostatic compound of claim 1, wherein the average size of the molecular sieve nanoparticles of the outer surface is 50 to 500 nm.

7. The hemostatic compound of claim 2, wherein the non-planar surface is composed of any one or combination of non-planar curves or non-planar lines.

8. The hemostatic compound of claim 1, wherein the molecular sieve is a molecular sieve after metal ion exchange.

9. The hemostatic compound of claim 8, wherein the metal ion is selected from the group consisting of strontium ion, calcium ion, magnesium ion, silver ion, zinc ion, barium ion, potassium ion, ammonium ion, and copper ion, and combination thereof.

10. The hemostatic compound of claim 1, wherein the fiber is a polymer containing hydroxyl groups in a repeating unit.

11. The hemostatic compound of claim 1, wherein the molecular sieves are independently dispersed on the fiber surface means that the minimum distance between the molecular sieve microparticles and the nearest molecular sieve microparticles is greater than or equal to one half of the sum of the particle sizes of the two molecular sieve microparticles, that is:
d≥r1+r2; where r1 and r2 respectively represent one half of the particle size of two adjacent molecular sieve microparticles; and d represents the minimum distance between two adjacent molecular sieve microparticles.

12. A preparation method for the hemostatic compound of claim 1, wherein the preparation method is an in-situ growth method, and the in-situ growth method comprises the following steps: (i) preparing a molecular sieve precursor solution and mix the molecular sieve precursor solution with a fiber; the fiber has not been subjected to pretreatment, and the pretreatment refers to a treatment method that destroys fiber structure of the fiber; (ii) processing the mixture of the fiber and the molecular sieve precursor solution obtained in step (i) with heat treatment to obtain a hemostatic compound.

13. The preparation method of claim 12, wherein the molecular sieve precursor solution does not include a templating agent.

14. The preparation method of claim 12, wherein in the step (ii), the temperature of the heat treatment is 60 to 220° C., and the time of heat treatment is 4 to 240 h.

15. The preparation method of claim 12, wherein in step (i), the mass ratio of the fiber to the molecular sieve precursor solution is 1:0.5 to 1:1000.

16. A composite material, wherein the composite material comprises the hemostatic compound according to claim 1.

17. The composite material of claim 16, wherein the composite material is a hemostatic textile.

18. The composite material of claim 17, wherein the hemostatic textile is selected from the group consisting of a hemostatic bandage, a hemostatic gauze, a hemostatic cloth, a hemostatic clothing, a hemostatic cotton, a hemostatic suture, a hemostatic paper, a hemostatic band-aid, and combination thereof.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) FIG. 1 is a schematic diagram showing the destruction of a fiber structure caused by pretreatment of fiber in the prior art.

(2) FIG. 2 is a scanning electron microscope image of a molecular sieve/fiber composite after pretreatment of fiber in the prior art, in which the molecular sieve is wrapped on the fiber surface in an agglomerated form (Journal of Porous Materials, 1996, 3 (3): 143-150).

(3) FIG. 3 is a scanning electron microscope image of a molecular sieve/fiber composite after pretreatment of fiber in the prior art, in which the molecular sieve is wrapped on the fiber surface in an agglomerated or lumpy form (Cellulose, 2015, 22 (3): 1813-1827).

(4) FIG. 4 is a scanning electron microscope image of a molecular sieve/fiber composite after pretreatment of fiber in the prior art, in which the molecular sieve is partially agglomerated and unevenly distributed on the fiber surface (Journal of Porous Materials, 1996, 3 (3): 143-150).

(5) FIG. 5 is a scanning electron microscope image of a molecular sieve/fiber composite after pretreatment of fiber the prior art, in which a gap exists between the fiber and the molecular sieve (Journal of Porous Materials, 1996, 3 (3): 143-150).

(6) FIG. 6 is a scanning electron microscope image of a Na-LTA molecular sieve/nanocellulose fiber composite bonded by polydiallyl dimethyl ammonium chloride in the prior art (ACS Appl. Mater. Interfaces 2016, 8, 3032-3040).

(7) FIG. 7 is a scanning electron microscope image of a NaY molecular sieve/fiber composite bonded by a cationic and anionic polymer adhesive in the prior art (Microporous & Mesoporous Materials, 2011, 145 (1-3): 51-58).

(8) FIG. 8 is a schematic diagram of a molecular sieve/fiber composite prepared by blend spinning in the prior art.

(9) FIG. 9 is a schematic diagram of molecular sieve/fiber composite prepared by electrospun in the prior art (U.S. Pat. No. 7,739,452B2).

(10) FIG. 10A is a scanning electron microscope image of a hemostatic compound according to the present disclosure (Bar=10 μm) (test parameter SU80100 3.0 kV; 9.9 mm).

(11) FIG. 10B is a scanning electron microscope image of the hemostatic compound according to the present disclosure (Bar=2 μm) (test parameter SU80100 3.0 kV; 9.9 mm).

(12) FIG. 11A is a scanning electron microscope image of fibers in the hemostatic compound before the fibers are bonded with the molecular sieve (test parameter SU80100 3.0 kV; 9.9 mm).

(13) FIG. 11B is a scanning electron microscope image of molecular sieves in the hemostatic compound after the fibers are removed from the hemostatic compound (test parameter SU80100 3.0 kV; 9.9 mm).

(14) FIG. 12 shows scanning electron microscope images of the inner surface (the contact surface between the molecular sieve and the fiber)(Bar=300 nm) and the outer surface (Bar=500 nm) of the molecular sieve of the hemostatic compound according to the present disclosure (test parameter SU80100 5.0 kV; 9.9 mm).

(15) FIG. 13 shows statistical distribution diagrams of particle sizes of nanoparticles on the inner surface and the outer surface of the molecular sieve of the hemostatic compound according to the present disclosure.

(16) FIG. 14 is a scanning electron microscope image of a molecular sieve according to Comparative Example 1 (test parameter SU80100 5.0 kV; 9.9 mm).

(17) FIG. 15 is a schematic diagram showing the different binding strength of the molecular sieves and fibers of the molecular sieve/fiber compound according to the Comparative Example 2 of the present disclosure, with the influence of the growth-matched coupling between molecular sieves and fibers.

(18) FIG. 16 is a schematic diagram of a molecular sieve/fiber composite bonded by an adhesive in the prior art. The fiber, the adhesive, and the molecular sieve form a sandwich-like structure, and the intermediate layer is an adhesive.

(19) FIG. 17A is a scanning electron microscope image of Combat Gauze commercialized by Z-Medica Co., Ltd. in Comparative Example 11 (Bar=50 μm).

(20) FIG. 17B is a scanning electron microscope image of Combat Gauze commercialized by Z-Medica Co., Ltd. in Comparative Example 11 (Bar=5 μm) FIG. 18 is a picture of a clay/fiber composite in an aqueous solution in the prior art.

(21) FIG. 19 is a graph of clay retention rate of clay/fiber composite of a prior art in an aqueous solution under ultrasonic condition for different times.

(22) FIGS. 20A-20B are schematic diagram of the positional relationship between two adjacent molecular sieve microparticles on the fiber surface of the hemostatic compound; wherein, FIG. 20A is the aggregation of molecular sieve on the fiber surface in the composite in the prior art, and FIG. 20B is the molecular sieve is independently dispersed on the fiber surface in the composite in the present disclosure.

DETAILED DESCRIPTION OF THE DISCLOSURE

(23) The present disclosure is further described below with reference to the drawings and embodiments.

(24) The “degree of ion exchange” is the ion exchange capacity of the compensation cations outside the molecular sieve framework and cations in the solution. The method for detecting the ion exchange capacity is: immersing hemostatic compounds in a 5M concentration strontium chloride, calcium chloride or magnesium chloride solution at room temperature for 12 hours to obtain a hemostatic compound after ion exchange, and measuring the degree of strontium ion, calcium ion or magnesium ion exchange of the molecular sieves of hemostatic compounds after ion exchange.

(25) “Effective specific surface area of molecular sieve” shows the specific surface area of the molecular sieve on the fiber surface in the hemostatic compound. The detection method of the effective specific surface area of the molecular sieve: the specific surface area of the hemostatic compound is analyzed by nitrogen isothermal adsorption and desorption, and the effective specific surface area of the molecular sieve=the specific surface area of the hemostatic compound−the specific surface area of the fiber.

(26) Detection method of “content of molecular sieve on fiber surface”: the mass fraction of molecular sieve on the fiber is analyzed using a thermogravimetric analyzer.

(27) The detection method of “uniform distribution of molecular sieves on the fiber surface” is: randomly taking n samples of the hemostatic compound at different locations and analyzing the content of the molecular sieve on the fiber surface, where n is a positive integer greater than or equal to 8. The coefficient of variance is also called the “standard deviation rate”, which is the ratio of the standard deviation to the mean multiplied by 100%. The coefficient of variation is an absolute value that reflects the degree of dispersion of the data. The smaller the value of the coefficient of variation, the smaller the degree of dispersion of the data, indicating that the smaller the difference in the content of molecular sieves on the fiber surface, the more uniform the distribution of molecular sieves on the fiber surface. The coefficient of variation of the content of the molecular sieves in the n samples is ≤15%, indicating that the molecular sieves are uniformly distributed on the fiber surface. Preferably, the coefficient of variation of the content of the molecular sieves is ≤10%, indicating that the molecular sieves are uniformly distributed on the fiber surface. Preferably, the coefficient of variation of the content of the molecular sieves is ≤5%, indicating that the molecular sieves are uniformly distributed on the fiber surface. Preferably, the coefficient of variation of the content of the molecular sieves is ≤2%, indicating that the molecular sieves are uniformly distributed on the fiber surface. Preferably, the coefficient of variation of the content of the molecular sieves is ≤1%, indicating that the molecular sieves are uniformly distributed on the fiber surface. Preferably, the coefficient of variation of the content of the molecular sieves is ≤0.5%, indicating that the molecular sieves are uniformly distributed on the fiber surface. Preferably, the coefficient of variation of the content of the molecular sieves is ≤0.2%, indicating that the molecular sieves are uniformly distributed on the fiber surface.

(28) The detection methods of D50 and D90 are: using scanning electron microscope to observe the molecular sieve microparticles on the surface of the hemostatic compound, and carrying out statistical analysis of particle size. D50 refers to the particle size corresponding to the cumulative particle size distribution percentage of the molecular sieve microparticles reaching 50%. D90 refers to the particle size corresponding to the cumulative particle size distribution percentage of the molecular sieve microparticles reaching 90%.

(29) The detection method of the binding strength between the molecular sieve and the fiber is: putting hemostatic compound in deionized water under ultrasonic condition for 20 min or more, and analyzing the content of the molecular sieve on the fiber surface by using a thermogravimetric analyzer. The retention rate on the fiber, the retention rate=(content of the molecular sieve on the fiber surface before the ultrasound-content of the molecular sieve on the fiber surface after the ultrasound)×100%/content of the molecular sieve on the fiber surface before the ultrasound. If the retention rate is greater than or equal to 90%, it indicates that molecular sieve and fiber form a growth-matched coupling, and molecular sieve is firmly bonded to fiber.

(30) Detection method of hemostatic function of hemostatic compound: The hemostatic function of hemostatic compound is evaluated by using a rabbit femoral artery lethal model. The specific steps are as follows: (1) before the experiment, white rabbits were anesthetized with sodium pentobarbital intravenously (45 mg/kg); their limbs and head were fixed, and supine on the experimental table; part of the hair was removed to expose the right groin of the hind limb. (2) Then, the femoral skin and muscle were cut longitudinally to expose the femoral artery, and the femoral artery was partially cut off (about half of the circumference). After the femoral artery was allowed to squirt freely for 30 seconds, the blood at the wound was cleaned with cotton gauze, and then the hemostatic compound was quickly pressed to the wound. After pressing for 60 seconds, the hemostatic compound is lifted up slightly every 10 seconds to observe the coagulation of the injured part and the coagulation time is recorded. Infrared thermometers are used to detect changes in wound temperature (before and after using hemostatic compound). (3) After hemostasis, observe the wound and suture the wound. The survival of the animals is observed for 2 hours after hemostasis. The survival rate=(total number of experimental white rabbits-number of deaths of white rabbits observed for 2 hours after hemostasis)×100%/total number of experimental white rabbits, wherein the number of experimental white rabbits in each group is n, n is a positive integer greater than or equal to 6. (4) The difference in weight of the hemostatic compound before and after use was recorded as the amount of blood loss during wound hemostasis.

Example 1

(31) The preparation method of the Y-type molecular sieve/cotton fiber hemostatic compound of the present disclosure includes the following steps:

(32) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with cotton fiber, and the mass ratio of the cotton fiber and the molecular sieve precursor solution is 1:20.

(33) (ii) The cotton fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve/cotton fiber hemostatic compound.

(34) Ten samples of the prepared Y-type molecular sieve/cotton fiber hemostatic compound were randomly taken at different locations, and the content of the Y-type molecular sieve on the fiber surface was analyzed by a thermogravimetric analyzer. The content of molecular sieve on the fiber in the ten samples was 25 wt %, 24.9 wt %, 25.1 wt %, 25.2 wt %, 25 wt %, 25 wt %, 24.9 wt %, 25 wt %, 25.1 wt %, 24.9 wt %. The average content of molecular sieves on the fibers in the ten samples was 25 wt %, the standard deviation of the samples is 0.1 wt %, and the coefficient of variation is 0.4%, which indicates that the Y-type molecular sieve is uniformly distributed on the fiber surface.

(35) The prepared Y-type molecular sieve/cotton fiber hemostatic compound was observed with a scanning electron microscope. Hemispherical molecular sieves with an average particle size of 5 μm are independently dispersed on the fiber surface, as shown in FIGS. 10A-10B. The molecular sieves microparticles of the molecular sieve/fiber composite are observed with a scanning electron microscope, and are performed statistical analysis of particle size to obtain a particle diameter D90 value of 25 μm and a particle diameter D50 value of 5 μm. The molecular sieves are obtained after removing the fibers by calcination. The inner surface of the molecular sieves in contact with the fiber is planar surface (caused by tight binding with the fiber), and the outer surface is spherical surface. The planar surface of the inner surface of the molecular sieves is a rough surface, as shown in FIGS. 11A-11B. The outer surface of the molecular sieve is composed of nanoparticles with corner angles, and the inner surface (the contact surface with the fiber) is composed of nanoparticles without corner angles (FIG. 12). The nanoparticles without corner angles make the inner surface of the molecular sieve match the fiber surface better, which is beneficial to the combination of the molecular sieve and the fiber. The average size of nanoparticles of the inner surface (61 nm) is significantly smaller than that of the outer surface (148 nm), and small-sized particles are more conducive to binding with fibers tightly (FIG. 13). The detection method of the binding strength between the molecular sieve and the fiber: the hemostatic compound is under ultrasonic condition in deionized water for 20 min, and the content of the Y-type molecular sieves on the fiber surface is analyzed by using a thermogravimetric analyzer. It is found that the content of the molecular sieve on the fiber surface is the same before and after ultrasonic condition. It shows that the retention rate of molecular sieve on the fiber is 100%, which indicates that the growth-matched coupling is formed between the molecular sieve and the fiber. The molecular sieve in the Y-type molecular sieve/cotton fiber hemostatic compound was analyzed by nitrogen isothermal adsorption and desorption, and a hysteresis loop was found in the isothermal adsorption curve, indicating that the molecular sieve has a mesoporous structure. Using the method for detecting the effective specific surface area of the molecular sieve as described above, the effective specific surface area of the molecular sieve in the Y-type molecular sieve/cotton fiber hemostatic compound prepared in this embodiment was measured to be 490 m.sup.2g.sup.−1. Using the method for detecting the ion exchange capacity of the molecular sieve in the Y-type molecular sieve/cotton fiber hemostatic compound, the degree of calcium ion exchange is 99.9%, the degree of magnesium ion exchange is 97%, and the degree of strontium ion exchange is 90%.

Comparative Example 1

(36) (1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution.

(37) (2) The molecular sieve precursor solution was heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve.

(38) The effective specific surface area of the Y-type molecular sieve was 490 m.sup.2g.sup.−1, the degree of calcium ion exchange was 99.9%, the degree of magnesium ion exchange was 97%, and the degree of strontium ion exchange was 90%.

(39) The effective specific surface area and ion exchange capacity of the above Y-type molecular sieve are used as reference values to evaluate the performance of the molecular sieve to the fiber surface in the Comparative Examples described below. The difference between this Comparative Example 1 and Example 1 is that only the Y-type molecular sieve is synthesized without adding fibers (the traditional solution growth method). Using a scanning electron microscope (FIG. 14), the synthesized molecular sieve is a complete microsphere composed of nanoparticles, and there is no rough planar surface (inner surface) in contact with the fibers compared with Example 1.

Comparative Example 2

(40) (1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution.

(41) (2) The molecular sieve precursor solution was heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve.

(42) (3) The above Y-type molecular sieve was added with deionized water to uniformly disperse the Y-type molecular sieve in an aqueous solution.

(43) (4) Immerse the cotton fiber in the solution prepared in step (3) and soak for 30 min.

(44) (5) Dry at 65° C. to obtain a Y-type molecular sieve/cotton fiber hemostatic complex (impregnation method).

(45) The difference between this Comparative Example and Example 1 is that only the Y-type molecular sieve is synthesized without adding fibers (the traditional solution growth method). Using a scanning electron microscope, the synthesized molecular sieve is a complete microsphere composed of nanoparticles, and there is no rough planar surface (inner surface) in contact with the fibers compared with Example 1. Therefore, there is no growth-matched coupling between the molecular sieve and the fiber surface (FIG. 15). The binding strength between the molecular sieve and the fiber was measured. The Y-type molecular sieve/cotton fiber hemostatic complex (impregnation method) was under the ultrasonic condition for 20 min, the retention rate of the molecular sieve on the fiber was 5%, indicating that the molecular sieve of Y-type molecular sieve/cotton fiber hemostatic complex (impregnation method) has a weak binding effect with the fiber, and the molecular sieve easily falls off (FIG. 15).

Comparative Example 3

(46) (1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution.

(47) (2) The molecular sieve precursor solution was heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve.

(48) (3) The above Y-type molecular sieve was added with deionized water to uniformly disperse the Y-type molecular sieve in an aqueous solution.

(49) (4) Spray the solution prepared in step (3) on cotton fibers

(50) (5) Dry at 65° C. to obtain a Y-type molecular sieve/cotton fiber hemostatic complex (spray method).

(51) The difference between this Comparative Example and Example 1 is that the synthesized molecular sieve is sprayed onto cotton fibers. Using a scanning electron microscope, there is no rough planar surface (inner surface) in contact with the fibers compared with Example 1. Therefore, there is no growth-matched coupling between the molecular sieve and the fiber surface. The binding strength between the molecular sieve and the fiber was measured. The hemostatic complex was under the ultrasonic condition for 20 min, the retention rate of the molecular sieve on the fiber was 2%, indicating that the molecular sieve of Y-type molecular sieve/cotton fiber hemostatic complex (spray method) has a weak binding effect with the fiber, and the molecular sieve easily falls off.

Comparative Example 4

(52) Refer to references for experimental steps (ACS Appl Mater Interfaces, 2016, 8(5):3032-3040).

(53) (1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution.

(54) (2) The molecular sieve precursor solution was heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve.

(55) (3) The above Y-type molecular sieve was added with deionized water to uniformly disperse the Y-type molecular sieve in an aqueous solution.

(56) (4) Cotton fibers were immersed in a 0.5 wt % polydiallyl dimethyl ammonium chloride (polyDADMAC) aqueous solution at 60° C. for 30 minutes to achieve adsorption of Y-type molecular sieves (polyDADMAC is an adhesive 1).

(57) (5) Dry at 65° C. to obtain a Y-type molecular sieve/cotton fiber hemostatic complex (including adhesive 1).

(58) The difference between this Comparative Example and Example 1 is that the synthesized molecular sieve is bonded to cotton fibers through an adhesive. After detection of scanning electron microscope, there is no rough planar surface (inner surface) in contact with the fiber, so there is no growth-matched coupling. The binding strength between the molecular sieve and the fiber was measured. The retention rate of the molecular sieve on the fiber was 50% under ultrasonic condition for 20 min, indicating that the molecular sieve has a weak binding strength with the fiber, and the molecular sieve in the Y-type molecular sieve/cotton fiber hemostatic complex (including adhesive 1) easily falls off. After detection of scanning electron microscope, the molecular sieve was unevenly distributed on the fiber surface, and there was agglomeration of the molecular sieve. After testing, with the addition of adhesive, the effective specific surface area of the molecular sieve became 320 m.sup.2g.sup.−1, the degree of calcium ion exchange became 75.9%, the degree of magnesium ion exchange became 57%, and the degree of strontium ion exchange became 50%. The complex material with added adhesive reduces the effective contact area between the molecular sieve and the reaction system, and reduces the ion exchange and pore substance exchange capacity of the molecular sieve.

(59) Ten samples of the prepared Y-type molecular sieve/cotton fiber hemostatic complex (including adhesive 1) were randomly taken at different locations, and the content of the Y-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 25 wt %, the standard deviation of the samples is 10 wt %, and the coefficient of variation is 40%, which indicates that the Y-type molecular sieve is unevenly distributed on the fiber surface.

Comparative Example 5

(60) Refer to references for experimental steps (Colloids & Surfaces B Biointerfaces, 2018, 165:199).

(61) (1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution.

(62) (2) The molecular sieve precursor solution was heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve.

(63) (3) The above Y-type molecular sieve was dispersed in a polymeric N-halamine precursor water/ethanol solution (polymeric N-halamine precursor is an adhesive 2).

(64) (4) The solution prepared in the step (3) was sprayed on cotton fibers

(65) (5) Dry at 65° C. to obtain a Y-type molecular sieve/cotton fiber hemostatic complex (including adhesive 2).

(66) The difference between this Comparative Example and Example 1 is that the molecular sieves with an adhesive were sprayed onto cotton fibers. After detection of scanning electron microscope, there is no rough planar surface (inner surface) in contact with the fiber, so there is no growth-matched coupling. The binding strength between the molecular sieve and the fiber was measured. The retention rate of the molecular sieve on the fiber was 41% under ultrasonic condition for 20 min, indicating that the molecular sieve has a weak binding strength with the fiber, and the molecular sieve in the Y-type molecular sieve/cotton fiber hemostatic complex (including adhesive 2) easily falls off. After detection of scanning electron microscope, the molecular sieve was unevenly distributed on the fiber surface, and there was agglomeration of the molecular sieve. After testing, with the addition of adhesive, the effective specific surface area of the molecular sieve became 256 m.sup.2g.sup.−1, the degree of calcium ion exchange became 65.9%, the degree of magnesium ion exchange became 47%, and the degree of strontium ion exchange became 42%. The complex material with added adhesive reduces the effective contact area between the molecular sieve and the reaction system, and reduces the ion exchange and pore substance exchange capacity of the molecular sieve.

(67) Ten samples of the prepared Y-type molecular sieve/cotton fiber hemostatic complex (including adhesive 2) were randomly taken at different locations, and the content of the Y-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 25 wt %, the standard deviation of the samples is 4 wt %, and the coefficient of variation is 16%, which indicates that the Y-type molecular sieve is unevenly distributed on the fiber surface.

Comparative Example 6

(68) Refer to references for experimental steps (Key Engineering Materials, 2006, 317-318:777-780).

(69) (1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution.

(70) (2) The molecular sieve precursor solution was heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve.

(71) (3) The Y-type molecular sieve sample was dispersed in a silica sol-based inorganic adhesive (adhesive 3) solution to obtain a slurry of a molecular sieve and adhesive mixture.

(72) (4) The prepared slurry in the step (3) was coated on cotton fibers, and then kept at room temperature for 1 h, and then kept at 100° C. for 1 h. The fibers were completely dried to obtain a Y-type molecular sieve/cotton fiber hemostatic complex (including adhesive 3).

(73) The difference between this Comparative Example and Example 1 is that the molecular sieves with a silica sol-based adhesive were coated on the cotton fibers. After detection of scanning electron microscope, there is no rough planar surface (inner surface) in contact with the fiber, so there is no growth-matched coupling. The binding strength between the molecular sieve and the fiber was measured. The retention rate of the molecular sieve on the fiber was 46% under ultrasonic condition for 20 min, indicating that the molecular sieve has a weak binding strength with the fiber, and the molecular sieve in the Y-type molecular sieve/cotton fiber hemostatic complex (including adhesive 3) easily falls off. After detection of scanning electron microscope, the molecular sieve was unevenly distributed on the fiber surface, and there was agglomeration of the molecular sieve. After testing, with the addition of adhesive, the effective specific surface area of the molecular sieve became 246 m.sup.2g.sup.−1, the degree of calcium ion exchange became 55.9%, the degree of magnesium ion exchange became 57%, and the degree of strontium ion exchange became 40%. The complex material with added adhesive reduces the effective contact area between the molecular sieve and the reaction system, and reduces the ion exchange and pore substance exchange capacity of the molecular sieve.

(74) Ten samples of the prepared Y-type molecular sieve/cotton fiber hemostatic complex (including adhesive 3) were randomly taken at different locations, and the content of the Y-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 25 wt %, the standard deviation of the samples is 8.5 wt %, and the coefficient of variation is 34%, which indicates that the Y-type molecular sieve is unevenly distributed on the fiber surface.

Comparative Example 7

(75) Refer to references for experimental steps (Journal of Porous Materials, 1996, 3(3):143-150).

(76) (1) The fibers were chemically pretreated. The fibers were first treated with ether for 20 minutes and sonicated in distilled water for 10 minutes.

(77) (2) A molecular sieve precursor solution was prepared, and a starting material was composed of 7.5Na.sub.2O:Al.sub.2O.sub.3:10SiO.sub.2:230H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution, followed by magnetic stirring for 1 h and standing at room temperature for 24 h. The molecular sieve precursor solution was mixed with pretreated cotton fibers.

(78) (3) The pretreated cotton fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 100° C. for 6 h to obtain a Y-type molecular sieve/cotton fiber hemostatic complex (pretreatment of fiber).

(79) The difference between this Comparative Example and Example 1 is that the fiber is pretreated, but the structure of the fiber itself is seriously damaged, which affects the characteristics such as the flexibility and elasticity of the fiber, and the fiber becomes brittle and hard. Therefore, the advantages of fiber as a carrier cannot be fully utilized. After detection by a scanning electron microscope, the molecular sieve was wrapped in the outer layer of the fiber, and there was still a gap between the fiber and the molecular sieve, indicating that this technology cannot tightly combine molecular sieve and fiber. Compared with Example 1, there is no rough planar surface (inner surface) in contact with the fiber, so there is no growth-matched coupling. The binding strength between the molecular sieve and the fiber was measured. The retention rate of the molecular sieve on the fiber was 63% under ultrasonic condition for 20 min, indicating that the molecular sieve has a weak binding strength with the fiber, and the molecular sieve in the Y-type molecular sieve/cotton fiber hemostatic complex (pretreatment of fiber) easily falls off. After testing, the agglomeration of molecular sieve makes the effective specific surface area of the molecular sieve to become 346 m.sup.2g.sup.−1, the degree of calcium ion exchange become 53%, the degree of magnesium ion exchange become 52%, and the degree of strontium ion exchange become 42%, which greatly reduces the effective contact area between the effective molecular sieve and the reaction system, and reduces the ion exchange and pore substance exchange capacity of the molecular sieve.

(80) Ten samples of the prepared Y-type molecular sieve/cotton fiber hemostatic complex (pretreatment of fiber) were randomly taken at different locations, and the content of the Y-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 25 wt %, the standard deviation of the samples is 9 wt %, and the coefficient of variation is 36%, which indicates that the Y-type molecular sieve is unevenly distributed on the fiber surface.

Comparative Example 8

(81) Refer to Chinese patent CN104888267A for experimental steps.

(82) (1) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution.

(83) (2) The molecular sieve precursor solution was heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve.

(84) (3) Prepare polyurethane urea stock solution.

(85) (4) The Y-type molecular sieve is ground in a dimethylacetamide solvent to obtain a Y-type molecular sieve solution.

(86) (5) The polyurethane urea stock solution and the Y-type molecular sieve solution are simultaneously placed in a reaction container, and spandex fibers are prepared through a dry spinning process, and finally woven into a Y-type molecular sieve/spandex fiber hemostatic complex (blend spinning).

(87) The difference between this Comparative Example and Example 1 is that the Y-type molecular sieve is blended and spun into the fiber, and there is no growth-matched coupling, and the molecular sieve and the fiber are simply physically mixed. In addition, the effective specific surface area of the molecular sieve becomes 126 m.sup.2g.sup.−1, the degree of calcium ion exchange becomes 45.9%, the degree of magnesium ion exchange becomes 27%, and the degree of strontium ion exchange becomes 12%. The blend spinning method is used to prepare hemostatic complex, which greatly reduces the effective contact area between the effective molecular sieve and the reaction system, and reduces the ion exchange and pore substance exchange capacity of the molecular sieve.

(88) The difference between this Comparative Example and Example 1 is that the Y-type molecular sieve is blended and spun into the fiber. After detection by a scanning electron microscope, molecular sieve and fiber were simply physically mixed, and there was no growth-matched coupling. After testing, this method makes the effective specific surface area of the molecular sieve become 126 m.sup.2g.sup.−1, the degree of calcium ion exchange become 45.9%, the degree of magnesium ion exchange become 27%, and the degree of strontium ion exchange become 12%. The blend spinning method is used to prepare hemostatic complex, which greatly reduces the effective contact area between the effective molecular sieve and the reaction system, and reduces the ion exchange and pore substance exchange capacity of the molecular sieve.

Comparative Example 9

(89) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution is mixed with cotton fiber, and the mass ratio of the cotton fiber and the molecular sieve precursor solution is 1:0.3.

(90) (ii) The cotton fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 100° C. for 24 h to obtain a Y-type molecular sieve/cotton fiber complex. The content of Y-type molecular sieve was 90 wt %.

(91) The difference between this Comparative Example and Example 1 is that the content of the Y-type molecular sieves is different. The content of the Y-type molecular sieves of this Comparative Example is greater than 80 wt %. After detection by a scanning electron microscope, the molecular sieves are clumped and wrapped on the fiber surface. The molecular sieves are not independently dispersed on the fiber surface, resulting in fiber stiffening. After testing, the agglomeration of molecular sieves makes the effective specific surface area of the molecular sieve become 346 m.sup.2g.sup.−1, the degree of calcium ion exchange become 53%, the degree of magnesium ion exchange become 52%, and the degree of strontium ion exchange become 42%. Both the effective specific surface area and ion exchange capacity are significantly reduced.

Example 2

(92) The preparation method of the chabazite/cotton fiber hemostatic compound of the present disclosure includes the following steps:

(93) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with cotton fiber, and the mass ratio of the cotton fiber and the molecular sieve precursor solution is 1:0.5.

(94) (ii) The cotton fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 80° C. for 36 h to obtain a chabazite/cotton fiber hemostatic compound.

(95) Ten samples of the prepared chabazite/cotton fiber hemostatic compound were randomly taken at different locations, and the content of the chabazite on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 25 wt %, the standard deviation of the samples is 2.5 wt %, and the coefficient of variation is 10%, which indicates that the chabazite is uniformly distributed on the fiber surface.

Example 3

(96) The preparation method of the X-type molecular sieve/silk fiber hemostatic compound of the present disclosure includes the following steps:

(97) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 5.5Na.sub.2O:1.65K.sub.2O:Al.sub.2O.sub.3:2.2SiO.sub.2:122H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with silk fiber, and the mass ratio of the silk fiber and the molecular sieve precursor solution is 1:10.

(98) (ii) The silk fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 100° C. for 12 h to obtain a X-type molecular sieve/silk fiber hemostatic compound.

(99) Eight samples of the prepared X-type molecular sieve/silk fiber hemostatic compound were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the eight samples was 15 wt %, the standard deviation of the samples is 1.5 wt %, and the coefficient of variation is 10%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 4

(100) The preparation method of the A-type molecular sieve/polyester fiber hemostatic compound of the present disclosure includes the following steps:

(101) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 3Na.sub.2O:Al.sub.2O.sub.3:2SiO.sub.2:120H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with polyester fiber, and the mass ratio of the polyester fiber and the molecular sieve precursor solution is 1:50.

(102) (ii) The polyester fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 100° C. for 4 h to obtain a A-type molecular sieve/polyester fiber hemostatic compound.

(103) Ten samples of the prepared A-type molecular sieve/polyester fiber hemostatic compound were randomly taken at different locations, and the content of the A-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 50 wt %, the standard deviation of the samples is 7.5 wt %, and the coefficient of variation is 15%, which indicates that the A-type molecular sieve is uniformly distributed on the fiber surface.

Example 5

(104) The preparation method of the ZSM-5 molecular sieve/polypropylene fiber hemostatic compound of the present disclosure includes the following steps:

(105) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 3.5Na.sub.2O:Al.sub.2O.sub.3:28SiO.sub.2:900H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with polypropylene fiber, and the mass ratio of the polypropylene fiber and the molecular sieve precursor solution is 1:200.

(106) (ii) The polypropylene fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 180° C. for 42 h to obtain a ZSM-5 molecular sieve/polypropylene fiber hemostatic compound.

(107) Ten samples of the prepared ZSM-5 molecular sieve/polypropylene fiber hemostatic compound were randomly taken at different locations, and the content of the ZSM-5 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 30 wt %, the standard deviation of the samples is 1.5 wt %, and the coefficient of variation is 5%, which indicates that the ZSM-5 molecular sieve is uniformly distributed on the fiber surface.

Example 6

(108) The preparation method of the β-molecular sieve/rayon fiber hemostatic compound of the present disclosure includes the following steps:

(109) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 2Na.sub.2O:1.1K.sub.2O Al.sub.2O.sub.3:50SiO.sub.2:750H.sub.2O:3HCl in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with rayon fiber, and the mass ratio of the rayon fiber and the molecular sieve precursor solution is 1:100.

(110) (ii) The rayon fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 135° C. for 25 h to obtain a β-molecular sieve/rayon fiber hemostatic compound.

(111) Eight samples of the prepared β-molecular sieve/rayon fiber hemostatic compound were randomly taken at different locations, and the content of the β-molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the eight samples was 25 wt %, the standard deviation of the samples is 2 wt %, and the coefficient of variation is 8%, which indicates that the β-molecular sieve is uniformly distributed on the fiber surface.

Example 7

(112) The preparation method of the mordenite/acetate fiber hemostatic compound of the present disclosure includes the following steps:

(113) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 5.5Na.sub.2O:Al.sub.2O.sub.3:30SiO.sub.2:810H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with acetate fiber, and the mass ratio of the acetate fiber and the molecular sieve precursor solution is 1:300.

(114) (ii) The acetate fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 170° C. for 24 h to obtain a mordenite/acetate fiber hemostatic compound.

(115) Ten samples of the prepared mordenite/acetate fiber hemostatic compound were randomly taken at different locations, and the content of the mordenite on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 35 wt %, the standard deviation of the samples is 5.25 wt %, and the coefficient of variation is 15%, which indicates that the mordenite is uniformly distributed on the fiber surface.

Example 8

(116) The preparation method of the L-type molecular sieve/carboxymethyl cellulose hemostatic compound of the present disclosure includes the following steps:

(117) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 2.5K.sub.2O:Al.sub.2O.sub.3:12SiO.sub.2:155H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with carboxymethyl cellulose, and the mass ratio of the carboxymethyl cellulose and the molecular sieve precursor solution is 1:1.

(118) (ii) The carboxymethyl cellulose and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 220° C. for 50 h to obtain a L-type molecular sieve/carboxymethyl cellulose hemostatic compound.

(119) Ten samples of the prepared L-type molecular sieve/carboxymethyl cellulose hemostatic compound were randomly taken at different locations, and the content of the L-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the ten samples was 10 wt %, the standard deviation of the samples is 0.2 wt %, and the coefficient of variation is 2%, which indicates that the L-type molecular sieve is uniformly distributed on the fiber surface.

Example 9

(120) The preparation method of the P-type molecular sieve/bamboo fiber hemostatic compound of the present disclosure includes the following steps:

(121) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:400H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with bamboo fiber, and the mass ratio of the bamboo fiber and the molecular sieve precursor solution is 1:2.

(122) (ii) The bamboo fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 150° C. for 96 h to obtain a P-type molecular sieve/bamboo fiber hemostatic compound.

(123) Twenty samples of the prepared P-type molecular sieve/bamboo fiber hemostatic compound were randomly taken at different locations, and the content of the P-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the twenty samples was 80 wt %, the standard deviation of the samples is 4 wt %, and the coefficient of variation is 5%, which indicates that the P-type molecular sieve is uniformly distributed on the fiber surface.

Example 10

(124) The preparation method of the merlinoite/linen fiber hemostatic compound of the present disclosure includes the following steps:

(125) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:320H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with linen fiber, and the mass ratio of the linen fiber and the molecular sieve precursor solution is 1:1000.

(126) (ii) The linen fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 120° C. for 24 h to obtain a merlinoite/linen fiber hemostatic compound.

(127) Fifteen samples of the prepared merlinoite/linen fiber hemostatic compound were randomly taken at different locations, and the content of the merlinoite on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 30 wt %, the standard deviation of the samples is 0.3 wt %, and the coefficient of variation is 1%, which indicates that the merlinoite is uniformly distributed on the fiber surface.

Example 11

(128) The preparation method of the X-type molecular sieve/wool hemostatic compound of the present disclosure includes the following steps:

(129) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with wool, and the mass ratio of the wool and the molecular sieve precursor solution is 1:20.

(130) (ii) The wool and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 60° C. for 16 h to obtain a X-type molecular sieve/wool hemostatic compound.

(131) Fifteen samples of the prepared X-type molecular sieve/wool hemostatic compound were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 27 wt %, the standard deviation of the samples is 2.1 wt %, and the coefficient of variation is 7.8%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 12

(132) The preparation method of the X-type molecular sieve/wood fiber hemostatic compound of the present disclosure includes the following steps:

(133) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with wood fiber, and the mass ratio of the wood fiber and the molecular sieve precursor solution is 1:5. The content of X-type molecular sieve was 42 wt %.

(134) (ii) The wood fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 90° C. for 24 h to obtain a X-type molecular sieve/wood fiber hemostatic compound.

(135) Fifteen samples of the prepared X-type molecular sieve/wood fiber hemostatic compound were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 42 wt %, the standard deviation of the samples is 2.1 wt %, and the coefficient of variation is 5%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 13

(136) The preparation method of the X-type molecular sieve/lactide polymer fiber hemostatic compound of the present disclosure includes the following steps:

(137) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with lactide polymer fiber, and the mass ratio of the lactide polymer fiber and the molecular sieve precursor solution is 1:50.

(138) (ii) The lactide polymer fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 90° C. for 30 h to obtain a X-type molecular sieve/lactide polymer fiber hemostatic compound. The content of X-type molecular sieve was 26 wt %.

(139) Fifteen samples of the prepared X-type molecular sieve/lactide polymer fiber hemostatic compound were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 26 wt %, the standard deviation of the samples is 1.1 wt %, and the coefficient of variation is 4.2%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 14

(140) The preparation method of the X-type molecular sieve/glycolide polymer fiber hemostatic compound of the present disclosure includes the following steps:

(141) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with glycolide polymer fiber, and the mass ratio of the glycolide polymer fiber and the molecular sieve precursor solution is 1:200.

(142) (ii) The glycolide polymer fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 120° C. for 24 h to obtain a X-type molecular sieve/glycolide polymer fiber hemostatic compound. The content of X-type molecular sieve was 37 wt %.

(143) Fifteen samples of the prepared X-type molecular sieve/glycolide polymer fiber hemostatic compound were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 37 wt %, the standard deviation of the samples is 0.2 wt %, and the coefficient of variation is 0.5%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 15

(144) The preparation method of the X-type molecular sieve/polylactide-glycolide polymer fiber hemostatic compound of the present disclosure includes the following steps:

(145) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with polylactide-glycolide polymer fiber, and the mass ratio of the polylactide-glycolide polymer fiber and the molecular sieve precursor solution is 1:20.

(146) (ii) The polylactide-glycolide polymer fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 90° C. for 24 h to obtain a X-type molecular sieve/polylactide-glycolide polymer fiber hemostatic compound. The content of X-type molecular sieve was 20 wt %.

(147) Fifteen samples of the prepared X-type molecular sieve/polylactide-glycolide polymer fiber hemostatic compound were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 20 wt %, the standard deviation of the samples is 0.04 wt %, and the coefficient of variation is 0.2%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 16

(148) The preparation method of the X-type molecular sieve/polyamide fiber hemostatic compound of the present disclosure includes the following steps:

(149) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with polyamide fiber, and the mass ratio of the polyamide fiber and the molecular sieve precursor solution is 1:0.8.

(150) (ii) The polyamide fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 90° C. for 24 h to obtain a X-type molecular sieve/polyamide fiber hemostatic compound. The content of X-type molecular sieve was 50 wt %.

(151) Fifteen samples of the prepared X-type molecular sieve/polyamide fiber hemostatic compound were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 50 wt %, the standard deviation of the samples is 2 wt %, and the coefficient of variation is 4%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 17

(152) The preparation method of the X-type molecular sieve/rayon-polyester fiber hemostatic compound of the present disclosure includes the following steps:

(153) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with rayon-polyester fiber, and the mass ratio of the rayon-polyester fiber and the molecular sieve precursor solution is 1:50.

(154) (ii) The rayon-polyester fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 110° C. for 28 h to obtain a X-type molecular sieve/rayon-polyester fiber hemostatic compound. The content of X-type molecular sieve was 5 wt %.

(155) Eight samples of the prepared X-type molecular sieve/rayon-polyester fiber hemostatic compound were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the eight samples was 5 wt %, the standard deviation of the samples is 0.05 wt %, and the coefficient of variation is 1%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 18

(156) The preparation method of the X-type molecular sieve/chitin fiber hemostatic compound of the present disclosure includes the following steps:

(157) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 10Na.sub.2O:Al.sub.2O.sub.3:9SiO.sub.2:300H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with chitin fiber, and the mass ratio of the chitin fiber and the molecular sieve precursor solution is 1:1.5.

(158) (ii) The chitin fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 90° C. for 24 h to obtain a X-type molecular sieve/chitin fiber hemostatic compound. The content of X-type molecular sieve was 20 wt %.

(159) Fifteen samples of the prepared X-type molecular sieve/chitin fiber hemostatic compound were randomly taken at different locations, and the content of the X-type molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 20 wt %, the standard deviation of the samples is 2.5 wt %, and the coefficient of variation is 12.5%, which indicates that the X-type molecular sieve is uniformly distributed on the fiber surface.

Example 19

(160) The preparation method of the AlPO.sub.4-5 molecular sieve/polyethylene fiber hemostatic compound of the present disclosure includes the following steps:

(161) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of Al.sub.2O.sub.3:1.3P.sub.2O.sub.5:1.3HF:425H.sub.2O:6C.sub.3H.sub.7OH in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with polyethylene fiber, and the mass ratio of the polyethylene fiber and the molecular sieve precursor solution is 1:20.

(162) (ii) The polyethylene fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 180° C. for 6 h to obtain the AlPO.sub.4-5 molecular sieve/polyethylene fiber hemostatic compound. The content of AlPO.sub.4-5 molecular sieve was 18 wt %.

(163) Fifteen samples of the prepared AlPO.sub.4-5 molecular sieve/polyethylene fiber hemostatic compound were randomly taken at different locations, and the content of the AlPO.sub.4-5 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 18 wt %, the standard deviation of the samples is 2.5 wt %, and the coefficient of variation is 13.9%, which indicates that the AlPO.sub.4-5 molecular sieve is uniformly distributed on the fiber surface.

Example 20

(164) The preparation method of the AlPO.sub.4-11 molecular sieve/polyvinyl chloride fiber hemostatic compound of the present disclosure includes the following steps:

(165) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of Al.sub.2O.sub.3:1.25P.sub.2O.sub.5:1.8HF:156H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with polyvinyl chloride fiber, and the mass ratio of the polyvinyl chloride fiber and the molecular sieve precursor solution is 1:0.5.

(166) (ii) The polyvinyl chloride fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 145° C. for 18 h to obtain the AlPO.sub.4-11 molecular sieve/polyvinyl chloride fiber hemostatic compound. The content of AlPO.sub.4-11 molecular sieve was 28 wt %.

(167) Fifteen samples of the prepared AlPO.sub.4-11 molecular sieve/polyvinyl chloride fiber hemostatic compound were randomly taken at different locations, and the content of the AlPO.sub.4-11 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 28 wt %, the standard deviation of the samples is 2 wt %, and the coefficient of variation is 7.1%, which indicates that the AlPO.sub.4-11 molecular sieve is uniformly distributed on the fiber surface.

Example 21

(168) The preparation method of the SAPO-31 molecular sieve/polyacrylonitrile fiber hemostatic compound of the present disclosure includes the following steps:

(169) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of Al.sub.2O.sub.3:P.sub.2O.sub.5:0.5SiO.sub.2:60H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with polyacrylonitrile fiber, and the mass ratio of the polyacrylonitrile fiber and the molecular sieve precursor solution is 1:1000.

(170) (ii) The polyacrylonitrile fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 175° C. for 14.5 h to obtain a SAPO-31 molecular sieve/polyacrylonitrile fiber hemostatic compound. The content of SAPO-31 molecular sieve was 34 wt %.

(171) Fifteen samples of the prepared SAPO-31 molecular sieve/polyacrylonitrile fiber hemostatic compound were randomly taken at different locations, and the content of the SAPO-31 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 34 wt %, the standard deviation of the samples is 5 wt %, and the coefficient of variation is 14.7%, which indicates that the SAPO-31 molecular sieve is uniformly distributed on the fiber surface.

Example 22

(172) The preparation method of the SAPO-34 molecular sieve/viscose fiber hemostatic compound of the present disclosure includes the following steps:

(173) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of Al.sub.2O.sub.3:1.06P.sub.2O.sub.5:1.08SiO.sub.2:2.09 morpholine:60H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with viscose fiber, and the mass ratio of the viscose fiber and the molecular sieve precursor solution is 1:20.

(174) (ii) The viscose fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 175° C. for 14.5 h to obtain a SAPO-34 molecular sieve/viscose fiber hemostatic compound. The content of SAPO-34 molecular sieve was 1 wt %.

(175) Fifteen samples of the prepared SAPO-34 molecular sieve/viscose fiber hemostatic compound were randomly taken at different locations, and the content of the SAPO-34 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 1 wt %, the standard deviation of the samples is 0.01 wt %, and the coefficient of variation is 1%, which indicates that the SAPO-34 molecular sieve is uniformly distributed on the fiber surface.

Example 23

(176) The preparation method of the SAPO-11 molecular sieve/chitin fiber hemostatic compound of the present disclosure includes the following steps:

(177) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of Al.sub.2O.sub.3:P.sub.2O.sub.5:0.5SiO.sub.2:60H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with chitin fiber, and the mass ratio of the chitin fiber and the molecular sieve precursor solution is 1:1.5.

(178) (ii) The chitin fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 175° C. for 48 h to obtain a SAPO-11 molecular sieve/chitin fiber hemostatic compound. The content of SAPO-11 molecular sieve was 35 wt %.

(179) Fifteen samples of the prepared SAPO-11 molecular sieve/chitin fiber hemostatic compound were randomly taken at different locations, and the content of the SAPO-11 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 35 wt %, the standard deviation of the samples is 1.5 wt %, and the coefficient of variation is 5%, which indicates that the SAPO-11 molecular sieve is uniformly distributed on the fiber surface.

Example 24

(180) The preparation method of the BAC-1 molecular sieve/chitin fiber hemostatic compound of the present disclosure includes the following steps:

(181) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 1.5B.sub.2O.sub.3:2.25Al.sub.2O.sub.3:2.5CaO:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with chitin fiber, and the mass ratio of the chitin fiber and the molecular sieve precursor solution is 1:100.

(182) (ii) The chitin fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 200° C. for 72 h to obtain a BAC-1 molecular sieve/chitin fiber hemostatic compound. The content of BAC-1 molecular sieve was 0.5 wt %.

(183) Fifteen samples of the prepared BAC-1 molecular sieve/chitin fiber hemostatic compound were randomly taken at different locations, and the content of the BAC-1 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 0.5 wt %, the standard deviation of the samples is 0.04 wt %, and the coefficient of variation is 8%, which indicates that the BAC-1 molecular sieve is uniformly distributed on the fiber surface.

Example 25

(184) The preparation method of the BAC-3 molecular sieve/chitin fiber hemostatic compound of the present disclosure includes the following steps:

(185) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 3B.sub.2O.sub.3:Al.sub.2O.sub.3:0.7Na.sub.2O:100H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with chitin fiber, and the mass ratio of the chitin fiber and the molecular sieve precursor solution is 1:2.

(186) (ii) The chitin fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 200° C. for 240 h to obtain a BAC-3 molecular sieve/chitin fiber hemostatic compound. The content of BAC-3 molecular sieve was 27 wt %.

(187) Fifteen samples of the prepared BAC-3 molecular sieve/chitin fiber hemostatic compound were randomly taken at different locations, and the content of the BAC-3 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 27 wt %, the standard deviation of the samples is 0.08 wt %, and the coefficient of variation is 0.3%, which indicates that the BAC-3 molecular sieve is uniformly distributed on the fiber surface.

Example 26

(188) The preparation method of the BAC-10 molecular sieve/chitin fiber hemostatic compound of the present disclosure includes the following steps:

(189) (i) A molecular sieve precursor solution was prepared, and a starting material was composed of 2.5B.sub.2O.sub.3:2Al.sub.2O.sub.3:CaO:200H.sub.2O in a molar ratio to synthesize a molecular sieve precursor solution. The molecular sieve precursor solution was mixed with chitin fiber, and the mass ratio of the chitin fiber and the molecular sieve precursor solution is 1:20.

(190) (ii) The chitin fiber and the homogeneously-mixed molecular sieve precursor solution were heat-treated at 160° C. for 72 h to obtain a BAC-10 molecular sieve/chitin fiber hemostatic compound. The content of BAC-10 molecular sieve was 21 wt %.

(191) Fifteen samples of the prepared BAC-10 molecular sieve/chitin fiber hemostatic compound were randomly taken at different locations, and the content of the BAC-10 molecular sieve on the fiber surface was analyzed. The average content of molecular sieves on the fibers in the fifteen samples was 21 wt %, the standard deviation of the samples is 0.9 wt %, and the coefficient of variation is 4.2%, which indicates that the BAC-10 molecular sieve is uniformly distributed on the fiber surface.

Comparative Examples 10 and 11

(192) Commercially available granular molecular sieve materials (Quikclot) and Combat Gauze from Z-Medica Co., Ltd., were taken as Comparative Examples 10 and 11, respectively. The hemostatic function of the materials was evaluated using a rabbit femoral artery lethal model.

(193) Among them, the commercial Combat Gauze is an inorganic hemostatic material (clay, kaolin) attached to the fiber surface. Observed from the scanning electron microscope, the inorganic hemostatic material is unevenly distributed on the fiber surface, as shown in FIGS. 17A-17B, and the material is not bonded to the fiber surface, and it is easy to fall off from the fiber surface. Clay retention rate on the gauze fiber is 10% or less under ultrasonic condition for 1 min; clay retention rate on the gauze fiber is 5% or less under ultrasonic condition for 5 min (FIG. 18); clay retention rate on the gauze fiber is 5% or less under ultrasonic condition for 20 min. This defective structural form limits the hemostatic properties of the hemostatic product and risks causing sequelae or other side effects.

(194) The certain size of the molecular sieve in the hemostatic compound can promote the uniform distribution of the molecular sieve on the fiber surface. The size of the molecular sieve and the average particle diameters of the inner and outer surface nanoparticles in the synthetic hemostatic compound of Examples 1-26 are shown in Table 1, according to the observation of the scanning electron microscope. In order to evaluate the binding strength between the molecular sieve and the fiber, the synthetic hemostatic compounds of Examples 1-26 were ultrasonicated in deionized water for 20, 40, 60, and 80 minutes, respectively. After ultrasonic testing, the retention rates of the molecular sieve on the fibers are shown in Table 2. In order to show that the molecular sieve in the hemostatic compound of the present disclosure maintains a good structure and performance on the fiber, after testing, the effective specific surface area and ion exchange capacity of the molecular sieve of Example 1-26 are shown in Table 3. In order to illustrate the superior hemostatic properties of hemostatic compounds, a rabbit femoral artery lethal model was used to evaluate the hemostatic function of hemostatic materials of Examples 1-26 and Comparative Example. After observing and testing, statistical data of hemostatic performance are shown in Table 4.

(195) TABLE-US-00001 TABLE 1 The particle size of molecular sieve of the molecular sieve/fiber hemostatic compound and the average particle size of the nanoparticles on the inner and outer surfaces Average particle Average particle Molecular Molecular size of the size of the Serial sieve sieve nanoparticles on the nanoparticles on the number Material D90/μm D50/μm outer surfaces/nm inner surfaces/nm Example 1 Y-type molecular sieve/cotton 25 5 148 61 fiber hemostatic compound Example 2 Chabazite/cotton fiber hemostatic 4 2 200 31 compound Example 3 X-type molecular sieve/silk fiber 20 10 256 51 hemostatic compound Example 4 A-type molecular sieve/polyester 50 30 141 12 fiber hemostatic compound Example 5 ZSM-5 molecular 30 15 190 11 sieve/polypropylene fiber hemostatic compound Example 6 β-molecular sieve/rayon fiber 6 4 110 33 hemostatic compound Example 7 Mordenite/acetate fiber hemostatic 7 3 109 23 compound Example 8 L-type molecular 8 5.5 300 22 sieve/carboxymethyl cellulose hemostatic compound Example 9 P-type molecular sieve/bamboo 10 8 240 60 fiber hemostatic compound Example 10 Merlinoite/linen fiber hemostatic 5 1 200 12 compound Example 11 X-type molecular sieve/wool 10 5 240 4 hemostatic compound Example 12 X-type molecular sieve/wood fiber 0.1 0.05 3 2 hemostatic compound Example 13 X-type molecular sieve/lactide 0.01 0.005 3 2 polymer fiber hemostatic compound Example 14 X-type molecular sieve/glycolide 0.5 0.25 10 4 polymer fiber hemostatic compound Example 15 X-type molecular 1 0.5 30 20 sieve/polylactide-glycolide polymer fiber hemostatic compound Example 16 X-type molecular sieve/polyamide 5 2.5 30 20 fiber hemostatic compound Example 17 X-type molecular sieve/rayon- 20 13 195 68 polyester fiber hemostatic compound Example 18 X-type molecular sieve/chitin fiber 20 10 150 100 hemostatic compound Example 19 AlPO.sub.4-5 molecular 7.5 5.5 500 22 sieve/polyethylene fiber hemostatic compound Example 20 AlPO.sub.4-11 molecular 5 4 200 2 sieve/polyvinyl chloride fiber hemostatic compound Example 21 SAPO-31 molecular 3 3 109 25 sieve/polyacrylonitrile fiber hemostatic compound Example 22 SAPO-34 molecular sieve/viscose 5 4 110 33 fiber hemostatic compound Example 23 SAPO-11 molecular sieve/chitin 8 5 211 10 fiber hemostatic compound Example 24 BAC-1 molecular sieve/chitin 12 10 256 51 fiber hemostatic compound Example 25 BAC-3 molecular sieve/chitin 15 8 500 32 fiber hemostatic compound Example 26 BAC-10 molecular sieve/chitin 10 8 50 4 fiber hemostatic compound

(196) TABLE-US-00002 TABLE 2 The binding strength of molecular sieve and fiber of molecular sieve/fiber hemostatic compound Retention rate Retention rate Retention rate Retention rate of molecular of molecular of molecular of molecular sieves on sieves on sieves on sieves on fibers under fibers under fibers under fibers under ultrasonic ultrasonic ultrasonic ultrasonic Serial condition for condition for condition for condition for number Material 20 min 40 min 60 min 80 min Example 1 Y-type molecular sieve/cotton 100% 100% 100% 100% fiber hemostatic compound Example 2 Chabazite/cotton fiber 100% 100% 100% 100% hemostatic compound Example 3 X-type molecular sieve/silk  95%  95%  95%  95% fiber hemostatic compound Example 4 A-type molecular 100% 100% 100% 100% sieve/polyester fiber hemostatic compound Example 5 ZSM-5 molecular  98%  98%  98%  98% sieve/polypropylene fiber hemostatic compound Example 6 β-molecular sieve/rayon fiber 100% 100% 100% 100% hemostatic compound Example 7 Mordenite/acetate fiber  91%  91%  91%  91% hemostatic compound Example 8 L-type molecular  99%  99%  99%  99% sieve/carboxymethyl cellulose hemostatic compound Example 9 P-type molecular sieve/bamboo 100% 100% 100% 100% fiber hemostatic compound Example 10 Merlinoite/linen fiber 100% 100% 100% 100% hemostatic compound Example 11 X-type molecular sieve/wool  90%  90%  90%  90% hemostatic compound Example 12 X-type molecular sieve/wood 100% 100% 100% 100% fiber hemostatic compound Example 13 X-type molecular sieve/lactide 100% 100% 100% 100% polymer fiber hemostatic compound Example 14 X-type molecular 100% 100% 100% 100% sieve/glycolide polymer fiber hemostatic compound Example 15 X-type molecular 100% 100% 100% 100% sieve/polylactide-glycolide polymer fiber hemostatic compound Example 16 X-type molecular  94%  94%  94%  94% sieve/polyamide fiber hemostatic compound Example 17 X-type molecular sieve/rayon-  96%  96%  96%  96% polyester fiber hemostatic compound Example 18 X-type molecular sieve/chitin  91%  91%  91%  91% fiber hemostatic compound Example 19 AlPO.sub.4-5 molecular 100% 100% 100% 100% sieve/polyethylene fiber hemostatic compound Example 20 AlPO.sub.4-11 molecular 100% 100% 100% 100% sieve/polyvinyl chloride fiber hemostatic compound Example 21 SAPO-31 molecular  90%  90%  90%  90% sieve/polyacrylonitrile fiber hemostatic compound Example 22 SAPO-34 molecular 100% 100% 100% 100% sieve/viscose fiber hemostatic compound Example 23 SAPO-11 molecular sieve/chitin 100% 100% 100% 100% fiber hemostatic compound Example 24 BAC-1 molecular sieve/chitin 100% 100% 100% 100% fiber hemostatic compound Example 25 BAC-3 molecular sieve/chitin 100% 100% 100% 100% fiber hemostatic compound Example 26 BAC-10 molecular sieve/chitin  99%  99%  99%  99% fiber hemostatic compound

(197) TABLE-US-00003 TABLE 3 Effective specific surface area and ion exchange capacity of molecular sieves with different hemostatic compound Effective specific Degree of Degree of Degree of Serial surface area of calcium magnesium Strontium number Material molecular sieves/(m.sup.2g.sup.−1) ion exchange ion exchange ion exchange Example 1 Y-type molecular sieve/cotton fiber 490 99.9%.sup.  97% 90% hemostatic compound Example 2 Chabazite/cotton fiber hemostatic 853 90.2%.sup.  92% 80% compound Example 3 X-type molecular sieve/silk fiber 741 91% 81% 80% hemostatic compound Example 4 A-type molecular sieve/polyester 502 85% 77% 70% fiber hemostatic compound Example 5 ZSM-5 molecular 426 80% 77% 70% sieve/polypropylene fiber hemostatic compound Example 6 β-molecular sieve/rayon fiber 763 95% 87% 85% hemostatic compound Example 7 Mordenite/acetate fiber hemostatic 412 95% 87% 85% compound Example 8 L-type molecular 858 85% 81% 80% sieve/carboxymethyl cellulose hemostatic compound Example 9 P-type molecular sieve/bamboo 751 91% 90% 85% fiber hemostatic compound Example 10 Merlinoite/linen fiber hemostatic 510 98.5%.sup.  97% 90% compound Example 11 X-type molecular sieve/wool 494 98% 97% 91% hemostatic compound Example 12 X-type molecular sieve/wood fiber 492 99% 97% 93% hemostatic compound Example 13 X-type molecular sieve/lactide 496 98.9%.sup.  97% 90% polymer fiber hemostatic compound Example 14 X-type molecular sieve/glycolide 480 97% 97% 91% polymer fiber hemostatic compound Example 15 X-type molecular sieve/polylactide- 499 99.7%.sup.  95% 87% glycolide polymer fiber hemostatic compound Example 16 X-type molecular sieve/polyamide 495 95% 94% 90% fiber hemostatic compound Example 17 X-type molecular sieve/rayon- 846 91.2%.sup.  90% 83% polyester fiber hemostatic compound Example 18 X-type molecular sieve/chitin fiber 751 91% 90% 85% hemostatic compound Example 19 AlPO.sub.4-5 molecular 426 — — — sieve/polyethylene fiber hemostatic compound Example 20 AlPO.sub.4-11 molecular 763 — — — sieve/polyvinyl chloride fiber hemostatic compound Example 21 SAPO-31 molecular 412 — — — sieve/polyacrylonitrile fiber hemostatic compound Example 22 SAPO-34 molecular sieve/viscose 858 — — — fiber hemostatic compound Example 23 SAPO-11 molecular sieve/chitin 510 — — — fiber hemostatic compound Example 24 BAC-1 molecular sieve/chitin fiber 494 — — — hemostatic compound Example 25 BAC-3 molecular sieve/chitin fiber 492 — — — hemostatic compound Example 26 BAC-10 molecular sieve/chitin 496 — — — fiber hemostatic compound

(198) TABLE-US-00004 TABLE 4 Hemostatic function of different hemostatic materials Rising temperature Serial Hemostatic Hemostatic of wound Blood Ease of Debridement Wound Survival number material time (° C.) loss (g) use effect condition rate Example 1 Y-type   2 min No   4 ± 0.5 Tailored Easy to Dry and 100% molecular for remove, no well sieve/cotton fiber wound other removal healed hemostatic size and required compound practical needs Example 2 Chabazite/cotton 1.8 min No   3 ± 0.5 Tailored Easy to Dry and 100% fiber hemostatic for remove, no well compound wound other removal healed size and required practical needs Example 3 X-type 1.8 min No   3 ± 0.4 Tailored Easy to Dry and 100% molecular for remove, no well sieve/silk fiber wound other removal healed hemostatic size and required compound practical needs Example 4 A-type   2 min No   3 ± 0.8 Tailored Easy to Dry and 100% molecular for remove, no well sieve/polyester wound other removal healed fiber hemostatic size and required compound practical needs Example 5 ZSM-5 2.5 min No   4 ± 0.8 Tailored Easy to Dry and 100% molecular for remove, no well sieve/polypropylene wound other removal healed fiber size and required hemostatic practical compound needs Example 6 β-molecular   2 min No   3 ± 0.8 Tailored Easy to Dry and 100% sieve/rayon fiber for remove, no well hemostatic wound other removal healed compound size and required practical needs Example 7 Mordenite/acetate 2.1 min No 3.5 ± 0.4 Tailored Easy to Dry and 100% fiber for remove, no well hemostatic wound other removal healed compound size and required practical needs Example 8 L-type molecular 2.7 min No 4.2 ± 0.4 Tailored Easy to Dry and 100% sieve/carboxymethyl for remove, no well cellulose wound other removal healed hemostatic size and required compound practical needs Example 9 P-type molecular 2.4 min No 4.3 ± 0.7 Tailored Easy to Dry and 100% sieve/bamboo for remove, no well fiber hemostatic wound other removal healed compound size and required practical needs Example 10 Merlinoite/linen 2.4 min No 4.3 ± 0.7 Tailored Easy to Dry and 100% fiber hemostatic for remove, no well compound wound other removal healed size and required practical needs Example 11 X-type   2 min No   4 ± 0.5 Tailored Easy to Dry and 100% molecular for remove, no well sieve/wool wound other removal healed hemostatic size and required compound practical needs Example 12 X-type 2.1 min No   4 ± 0.5 Tailored Easy to Dry and 100% molecular for remove, no well sieve/wood fiber wound other removal healed hemostatic size and required compound practical needs Example 13 X-type 2.4 min No 4.3 ± 0.3 Tailored Easy to Dry and 100% molecular for remove, no well sieve/lactide wound other removal healed polymer fiber size and required hemostatic practical compound needs Example 14 X-type 2.1 min No 3.5 ± 0.5 Tailored Easy to Dry and 100% molecular for remove, no well sieve/glycolide wound other removal healed polymer fiber size and required hemostatic practical compound needs Example 15 X-type 2.3 min No 3.8 ± 0.5 Tailored Easy to Dry and 100% molecular for remove, no well sieve/polylactide- wound other removal healed glycolide size and required polymer fiber practical hemostatic needs compound Example 16 X-type 2.5 min No 4.2 ± 0.5 Tailored Easy to Dry and 100% molecular for remove, no well sieve/polyamide wound other removal healed fiber hemostatic size and required compound practical needs Example 17 X-type 2.4 min No 4.4 ± 0.5 Tailored Easy to Dry and 100% molecular for remove, no well sieve/rayon- wound other removal healed polyester fiber size and required hemostatic practical compound needs Example 18 X-type   2 min No   3 ± 0.8 Tailored Easy to Dry and 100% molecular for remove, no well sieve/chitin fiber wound other removal healed hemostatic size and required compound practical needs Example 19 AlPO.sub.4-5   2 min No   3 ± 0.8 Tailored Easy to Dry and 100% molecular for remove, no well sieve/polyethylene wound other removal healed fiber size and required hemostatic practical compound needs Example 20 AlPO.sub.4-11 2.1 min No 3.5 ± 0.4 Tailored Easy to Dry and 100% molecular for remove, no well sieve/polyvinyl wound other removal healed chloride fiber size and required hemostatic practical compound needs Example 21 SAPO-31 2.1 min No 3.2 ± 0.4 Tailored Easy to Dry and 100% molecular for remove, no well sieve/polyacrylonitrile wound other removal healed fiber size and required hemostatic practical compound needs Example 22 SAPO-34 2.4 min No   4 ± 0.7 Tailored Easy to Dry and 100% molecular for remove, no well sieve/viscose wound other removal healed fiber hemostatic size and required compound practical needs Example 23 SAPO-11 2.5 min No 4.2 ± 0.5 Tailored Easy to Dry and 100% molecular for remove, no well sieve/chitin fiber wound other removal healed hemostatic size and required compound practical needs Example 24 BAC-1 2.4 min No 4.4 ± 0.5 Tailored Easy to Dry and 100% molecular for remove, no well sieve/chitin fiber wound other removal healed hemostatic size and required compound practical needs Example 25 BAC-3   2 min No   3 ± 0.8 Tailored Easy to Dry and 100% molecular for remove, no well sieve/chitin fiber wound other removal healed hemostatic size and required compound practical needs Example 26 BAC-10 2.4 min No 3.4 ± 0.1 Tailored Easy to Dry and 100% molecular for remove, no well sieve/chitin fiber wound other removal healed hemostatic size and required compound practical needs Comparative Y-type 5.4 min 2 ± 1 7.4 ± 0.1 Tailored Part of the A large 60% Example 2 molecular for molecular blood clot sieve/cotton fiber wound sieves fall forms on hemostatic size and from the fiber the complex practical and stick to surface of (impregnation needs the wound, the method) making them wound, difficult to which is remove gererally healed Comparative Y-type 5.2 min 3 ± 1 7.6 ± 0.1 Tailored Part of the A large 55% Example 3 molecular for molecular blood clot sieve/cotton fiber wound sieves fall forms on hemostatic size and from the fiber the complex (spray practical and stick to surface of method) needs the wound, the making them wound, difficult to which is remove gererally healed Comparative Y-type 6.2 min 7 ± 1 5.5 ± 0.2 Tailored Part of the A large 65% Example 4 molecular for molecular blood clot sieve/cotton fiber wound sieves fall forms on hemostatic size and from the fiber the complex practical and stick to surface of (including needs the wound, the adhesive 1) making them wound, difficult to which is remove gererally healed Comparative Y-type 5.4 min 4 ± 1 8.5 ± 0.2 Tailored Part of the A large 45% Example 5 molecular for molecular blood clot sieve/cotton fiber wound sieves fall forms on hemostatic size and from the fiber the complex practical and stick to surface of (including needs the wound, the adhesive 2) making them wound, difficult to which is remove gererally healed Comparative Y-type   6 min 2 ± 1 7.5 ± 0.1 Tailored Part of the A large 40% Example 6 molecular for molecular blood clot sieve/cotton fiber wound sieves fall forms on hemostatic size and from the fiber the complex practical and stick to surface of (including needs the wound, the adhesive 3) making them wound, difficult to which is remove gererally healed Comparative Y-type 6.5 min 2 ± 1 7.1 ± 0.1 hard Part of the A large 45% Example 7 molecular and molecular blood clot sieve/cotton fiber brittle, sieves fall forms on hemostatic and does from the fiber the complex not make and stick to surface of (pretreatment of good the wound, the fiber) contact making them wound, with the difficult to which is wound remove gererally healed Comparative Y-type 5.4 min No 9.1 ± 0.1 Tailored Easy to A large 40% Example 8 molecular for remove, no blood clot sieve/spandex wound other removal forms on fiber hemostatic size and required the complex (blend practical surface of spinning) needs the wound, which is gererally healed Comparative Quikclot   3 min 10 ± 2  6.5 ± 0.9 Difficult The granules The 50% Example 10 molecular sieve to adjust need to be wound granule dosage washed with serveral time slight with burns was physiological washed saline, and by can plug in physiological blood vessels saline, and it was easy to rebleed. Comparative Combat Gauze 7.5 min No 12.7 ± 0.8  Tailored Part of the A large 40% Example 11 (Clay/fiber for clay falls off blood clot hemostatic wound the fibers. forms on complex) size and Due to the the practical large amount wound needs of bleeding, a surface, large area of making it blood clot is difficult formed on the to wound observe surface, the actual which adheres blood to the wound vessel surface and is healing easy to rebleed when cleared.

(199) The above results show that: Examples 1-26 list the molecular sieve/fiber hemostatic compounds with different molecular sieves and different fibers, and the inner surface of the molecular sieve of the molecular sieve/fiber hemostatic compounds of Examples 1-26 in contact with the fibers is a rough planar surface matched with the fiber surface. Ultrasound the molecular sieve/fiber hemostatic compounds in deionized water for ≥20 min, and use a thermogravimetric analyzer to analyze the content of molecular sieves on the fiber surface. The retention rate of molecular sieves is ≥90%, indicating that a growth-matched coupling is formed between the molecular sieve and the fiber. The molecular sieve is firmly bonded to the fiber. The adhesive content of the contact surface between the molecular sieve and the fiber is zero in Examples 1-26 of the present disclosure, and the degree of calcium ion exchange of the molecular sieve is ≥90%, the degree of magnesium ion exchange is ≥75%, and the degree of strontium ion exchange is ≥70%. It overcomes the defects of high synthetic cost, low effective surface area, and clogging of molecular sieve channels, which exists on the fibers through the adhesive. Although the molecular sieve/fiber hemostatic compound has a reduced amount of molecular sieve compared to the molecular sieve granules, the hemostatic effect of the molecular sieve/fiber hemostatic compound is better than the commercial molecular sieve granules (Quikclot), which further solves the problem of water absorption and heat release. The molecular sieve of the present disclosure is uniformly distributed on the fiber surface with a certain size, and a growth-matched coupling is formed between the molecular sieve and the fiber. The molecular sieve has a strong binding strength with the fiber. The molecular sieve has a high effective specific surface area and substance exchange capacity on the fiber surface. The hemostatic effect of hemostatic compounds is superior to that of composite materials with weak binding strength between molecular sieves and fiber or low effective specific surface area or low material exchange capacity in the prior art. The hemostatic compounds have a short hemostatic time, low blood loss, and high survival rate in the rabbit femoral artery lethal model, and the molecular sieve/fiber compounds are safe during hemostatic process. In addition, the hemostatic compounds also have the following advantages: (i) the wound surface after hemostasis is easy to clean up and convenient for post-processing by professionals; (ii) hemostatic compounds can be tailored for wound size and practical needs; (iii) the wound after hemostasis is dry and heals well after treated with the hemostatic compounds.

(200) The above embodiments are only used to illustrate the present disclosure and are not used to limit the scope of the present disclosure. In addition, it should be understood that after reading the teaching of the present disclosure, those skilled in the art can make various changes or modifications to the present disclosure, and these equivalent forms also fall within the scope defined by the appended claims of the present application.