Composition and method of skin relief cream useful for eczema, psoriasis, lipoma, burn wounds, scars, keloids, shingles, dry skin disorders, and skin allergies

Abstract

The present invention relates generally to a herbal cream formulation useful for treatment of skin diseases and disorders, therapeutic and cosmetic applications. More specifically, the present invention relates to the composition of a topical cream useful for treating Eczema, Psoriasis, burn wounds, scars, keloids, Lipomas, Shingles, dry skin disorders, skin allergies and other related skin diseases. The present invention includes the composition and method of making the topical cream.

Claims

1. A composition in the form of a cream for therapeutic and cosmetic treatment of general skin disorders including Psoriasis, Eczema, burn wounds, Shingles, dispigmentation, discoloration, Vitiligo, dry skin, Keloids, scars, lipoma, allergic rashes and irritation, fungal infections, said composition comprising: (a) A plurality of plant extracts formed as an oil, a powder, or mixtures thereof, the plant extracts including: Solanum Nigrum water extract in 2 to 75 wt. %, said Solanum Nigrum having been dried for at least 72 hours in direct sunlight; Dioscorea bulbifera Linn water extract in 2 to 6 wt. %, said Dioscorea bulbifera Linn having been dried for at least 72 hours in direct sunlight; the mixture of the plurality of plant extracts having been heated to 30 to 50 degrees C.; and Garcinia Indica extract in 2 to 10 wt. %; Ricinus Communis oil extract in 2 to 20 wt. %; juice of Aloe Vera in 2 to 8 wt. %; Polyoxyethylene (20) sorbitan monooleate emulsifying agent in 0.005 wt. % to 0.01 wt. %; fragrant oil selected from the group consisting of Rose, Basil, Chamomile oil and Mentha oil in 0.005 wt. % to 0.01 wt. %; (b) further comprising a drug having anti-inflammatory and wound healing properties selected from the group consisting of Salicylic acid in 1 to 4 wt. %, Piroxicam in 1 to 2 wt. %, Turmeric Powder in 0.1 to 1 wt. % and mixtures thereof; (c) and a first base or a second base, said first base comprising propylene glycol, cross-linked polyacrylic acid polymer, mono-ethanol amine and petroleum jelly in 2 to 20 parts by weight or mixtures thereof; and said second base comprising an aqueous cream base or gel containing cross-linked polyacrylic acid polymer in 1 to 4 wt. %, water in 20 to 40 wt. %, and a humectant in 1 to 4 wt. %.

2. The composition as claimed in claim 1 wherein the humectant is glycerin and ranges between 1 to 4 wt. %.

3. The composition as claimed in claim 1 wherein the humectant is propylene glycol in 1 to 3 wt. %.

4. The composition as claimed in claim 1 useful in enhancing the healing of skin during Psoriasis, Eczema, Burn Wounds, Scars, Lipoma, Shingles, discoloration, dry skin disorders, fungal infections and skin allergies with minimum recurrences.

5. The composition as claimed in claim 1 which can be used alone or in combination with oral folic acid supplements.

6. The composition as claimed in claim 1 which is lethal to fungus, mold, bacteria, and yeasts, thus providing an effective treatment of Psoriasis, Eczema, burns, keloids, scars, contact dermatitis, shingles and dermatophyte fungi.

7. The composition as claimed in claim 1, wherein said composition provides a synergistic effect which enables said composition to quicken healing when applied to cracked skin.

Description

BRIEF DESCRIPTION OF DRAWINGS

(1) TABLE-US-00001 Table I Detail Description of Ingredients Table II Method of Preparation of the Composition

DETAIL DESCRIPTION OF THE INVENTION

(2) All illustrations of the drawings are for the purpose of describing selected versions of the present invention and are not intended to limit the scope of the present invention.

(3) The present invention provides a herbal formulation for the treatment and relief of skin diseases and disorders including Psoriasis, Eczema, burn wounds, Shingles, scaring of skin to form keloids, Lipoma, dry skin, skin allergies, contact dermatitis and cracked heels, etc. More specifically, the preferred embodiment of the formulation of the present invention comprises castor seed oil, kokum seed extract, solanum nigrum (black nightshade) extract, Aloe Vera, Air Potato Extract and emulsifying agent. As can be seen in TABLE I, the Castor Seed, also known as Ricinus Communis, is in oil form and of 2-20% by weight in the formulation. The Solanum Nigrum extract can be oil and/or powder or pulp, is of 2-75% by weight. The extract of Kokum Seed, also known as Garcinia Indica, is in the form of oil and of 2-10% by weight. The extract of Air Potato also known as Dioscorea bulbifera Linn can be a powder or pulp, is of 2-6% by weight. The emulsification agent is no more than 0.01% by weight in the formulation. The content of Aloe Vera is no more than 8% by weight.

(4) TABLE-US-00002 TABLE I Ingredients Ingredient % By Weight Castor seed oil 2%-20% Solanum nigrum 2%-75% Kokum seed oil 2%-10% Air Potato Extract 2%-6%  Emulsifying agent ≤0.01% Aloe vera   ≤8%

(5) The preferred embodiment of the formulation of the present invention, as seen in TABLE I, includes extracts and/or oils from medicinal plants thereof having anti-inflammatory, anti-tumor, anti-cancer, antimicrobial, antioxidant, antihistaminic and wound healing properties. Thus, the present invention offers a safe and eco-friendly treatment and does not produce any harmful effects on the human skin. The plant extracts of Ricinus Communis(Castor Seed Oil), Solanum Nigrum(Black Nightshade), Dioscorea bulbifera Linn (Air Potato), Aloe Vera and Garcinia Indica (Kokum Seed) used in the present invention may be from any part of the plant including, but not limited to, leaf, root, bark, exudation of the bark, flower, seed, fruit, stem, and branch.

(6) In another embodiment of the present invention, the formulation may comprise Salicylic acid, Piroxicam, Diclofenac sodium, or any combination thereof in addition to the formulation listed in TABLE I. This embodiment of formulation further enhances the anti-inflammatory and wound healing functions of the present invention.

(7) In still another embodiment of the present invention, the formulation may comprise an aqueous cream base including, but not limited to, emulsifying ointment BP 1993, preservative, and water. The formulation may comprise a gel base including, but not limited to, propylene glycol, Carbopol 934, and mono-ethanol amine, or any combination thereof.

(8) The present invention can be used alone or in combination with oral folic acid supplements. Further, the present invention is lethal to fungus, mold, bacteria, and yeasts, thus, providing an effective treatment of eczema, skin psoriasis, burns, keloids, scars, lipoma, contact dermatitis, Shingles and dermatophyte fungi.

(9) The present invention further comprises a method for preparing an herbal cream or gel using any of the embodiments of the formulation of the present invention described above. The first step in the preparation of these formulations involves a process of making the plant extract of the Solanum Nigrum and Dioscorea bulbifera Linn suitable for incorporating into a cream or gel base. The appropriate portion of the plants are collected and dried in sunlight for at least 72 hours or until the material is dry. A specific amount of the Solanum Nigrum and Dioscorea bulbifera Linn material is then extracted with a solvent including, but not limited to, water-hexane, chloroform, ethanol, methanol, and water. The choice of solvent depends upon the type of material expected at the end of the extraction process. The extraction process and creation of the cream of the present invention is described in detail in TABLE II.

(10) The formulations and method of the present invention are based on pharmacological scientific principles rather than literature describing common herbs that are good for the skin. While there are a number of herbal creams on the worldwide market available for the treatment of skin disorders, few contain the active ingredients as described in this invention. Moreover, it has been reported that many marketed herbal topical skin products, either don't work or they are misleading, claiming to be natural, but adulterated with potent steroids.

(11) Because of the intensive study conducted by the inventors with the aim of achieving aforementioned objectives, new processes for the preparation of cream formulations for topical use were developed employing herbal drugs which are from natural origin, incorporating them into cream bases along with synthetic materials which are known to possess water retaining properties. Thus, the present invention provides an effective treatment of skin relief for psoriasis, eczema, burns, keloids, scars, contact dermatitis, lipoma, Shingles and dermatophyte fungi and an efficient method of making the formulations.

(12) Although the invention has been explained in relation to its preferred embodiment, it is to be understood that many other possible modifications and variations can be made without departing from the spirit and scope of the invention.

(13) TABLE-US-00003 TABLE II Method of Preparation No. Step Sub Step 1. Preparation of decoction 1. Take a specific amount of Solanum nigrum (leaf,  root, stem, flower, fruits, etc.) after at least 72  hours of drying in direct Sunlight. 2. Add specific amount of Air Potato Extract (leaf,  root, stem, flower, fruits, etc.) after at least 72  hours of drying in direct Sunlight. 3. Prepare pulp using a mixer grinder. 4. Add eight times of water by weight to the mixer. 5. Heat the mixture to 30-50° C. to reduce the  mixture to 50% by weight. 6. Filter and collect filtrate in a stainless-steel pot. 2. Preparation of Solanum nigrum 1. Take one part of pulp prepared in step 1 in a and Dioscorea bulbifera Linn oil stainless-steel pot. 2. Add four parts of Castor oil to the pot. 3. Add 2 parts of Aloe Vera to the pot. 4. Add 16 parts of the decoction prepared in Step 1  to the pot. 5. Heat the mixture to 100-120° C. to dry the  mixture to no more than 5% moisture by weight. 6. Filter and collect filtrate in a stainless-steel pot. 3. Preparation of cream 1. Take 2 kg of the Solanum nigrum and Dioscorea  bulbifera Linn oil prepared in Step 3 in a  homogenizer. 2. Heat 1 kg of Kokum seed to 70-80° C. to melt in a  stainless-steel pot. 3. Add the melted Kokum seed to the homogenizer. 4. Add emulsifying agent of no more than 0.01% by  weight to the mixture. 5. Homogenize the mixture to make a cream. 6. Collect the cream in a stainless-steel pot. 4. Storage 1. Store the resulted cream in cool, dry place.

(14) The above formulation listed in Table II was tested for multiple cases of Psoriasis, Eczema, Lipoma, Shingles, Burn Wounds, Keloids and Scars for relief on human subjects of both sexes of different age groups in India during a period of 2 years.

(15) The skin cracks in all cases were healed within 1 to 2 weeks when applied twice daily. Moderate skin problems and wounds were healed within 7 days and severe skin cracks were healed by continuous use of 1 to 2 months in case of Psoriasis and Eczema. The natural suppleness of the skin was restored in all cases after healing. Few subjects reported healing of even leprosy wounds on hands, fingers and toes. Several subjects with severe case of Psoriasis reported total healing of skin on both hands after continuous use of 1 to 2 months. Multiple cases also reported immediate relief from Shingles pain. In all the subjects, soothing effect was observed after one or two applications and new rejuvenated skin was formed in matter of days.

(16) The above observations ascertain that formulation described in Table II above is best for various types of skin diseases, rash, skin allergies and other skin problems in all cases.

(17) The main advantages of the present invention are: 1. It spreads evenly on the applied parts and after a light massage, gets absorbed in the skin. After application, the skin has an immediate softening and soothing effect. 2. It heals the skin cracks and wounds rapidly and makes the skin soft and supple in all observed cases. 3. The formulation also acts as an antiseptic in case of wounds from Eczema, Psoriasis, Burn Wounds, cuts and rashes. It is observed that the formulation stops the skin scaling, minimizes skin fissures, red rashes and pain and helps grow new skin quickly in cases of Eczema, Psoriasis, burn wounds and severe itching. 4. The formulation is an emollient cream which prevents water loss from the skin cracks and promotes healing in cases of Eczema, Psoriasis and Burn wounds. It also has antifungal activity and hence can be used for fungal infections on skin. 5. The present formulations, apart from healing the cracks on skin, are useful in arresting the bleeding due to cracks and reducing the pain as well as give soothing relief in most cases. 6. Once the cracks on skin are cured, the recurrence of cracks is minimum, compared to commercially available products in the market. 7. The present formulation has moisturizing effect on skin and hence can be used for any dry skin disorders in cosmetic therapy. 8. The present formulation provides excellent protection from darkening of skin due to minor cuts, burns, wounds and pimples. 9. The present formulation has good antiallergic activity in case of insect bites, rashes and reduce itching on the skin. 10. The present formulations can also be used as base material in which ingredients have analgesic, anticancer, antioxidant and anti-inflammatory properties which can be incorporated for potentiation of their activities.