Use of a combination of taurine or a derivate thereof and a grape extract for improving the quality of the nails

Abstract

The invention relates to the oral cosmetic use of a combination of active agents comprising at least taurine, a derivative thereof and/or an acceptable salt thereof and at least one grape extract, as cosmetic active agents for improving the quality of the nails. More particularly, the present invention relates to the oral cosmetic use of such a combination for improving the solidity of the nails and for reducing and/or preventing their splitting.

Claims

1. A cosmetic composition suitable for oral administration in the form of a coated tablet comprising a core and excipients for the core, and a coating comprising film-coating agents, wherein the core comprises active ingredients and excipients for the core, wherein the active ingredients consist of, relative to the total weight of the composition: 10 to 15% by weight of taurine, a structural analogue thereof and/or an acceptable salt thereof, an extract of grape seeds comprising polyphenol, wherein the polyphenol is present in the composition in amounts of 10-60% by weight relative to the total weight of the composition, 1 to 10% by weight of zinc gluconate, 0.0005% to 0.002% by weight of vitamin B8, and 2 to 10% by weight of vitamin C, the excipients for the core comprise croscarmellose sodium, and the film-coating agents comprise hydroxypropylmethyl cellulose and hydroxypropyl cellulose.

2. Packaging kit or assembly comprising: (i) the composition of claim 1, which is adapted for oral administration, and (ii) an antifungal agent intended for topical application, the composition (i) and the antifungal agent (ii) being intended to be administered independently of each other, separately, simultaneously or consecutively over time.

Description

EXAMPLES

Example 1

(1) Oral Composition in Tablet Form

(2) TABLE-US-00001 (% by weight relative to the total weight of the Ingredients (mg/tablet) composition) Taurine.sup.(1) 75 10.641 Zinc gluconate.sup.(2) 25.74 3.652 Grape seed extract.sup.(3) 93.5 13.266 Vitamin B8.sup.(4) 0.016 0.002 Vitamin C.sup.(5) 18.34 2.602 Excipients for the core Dibasic calcium phosphate 218 30.931 dihydrate Microcrystalline cellulose 214 30.363 Croscarmellose sodium 20 2.838 Silicon dioxide 7 0.993 Magnesium stearate 6 0.851 Film-coating agents Hydroxypropylmethyl-cellulose 9.18 1.303 Hydroxypropylcellulose 9.18 1.303 Talc 5.44 0.772 Titanium dioxide 3.21 0.455 Yellow iron oxide 0.12 0.017 Red iron oxide 0.07 0.010 .sup.(1)sold under the name Taurine by the company Quimdis .sup.(2)sold under the name Gluconal Zn-P by the company Arnaud .sup.(3)sold under the name Vitaflavan 50 by the company DRT .sup.(4)sold under the name D-Biotin by the company DSM .sup.(5)sold under the name Ascorbic acid 90% granulation by the company DSM One to three of these tablets may be taken per day.

(3) This composition may be prepared according to the process described below:

(4) The D-biotin and the excipients are first mixed together. Next, the taurine, the zinc gluconate, the grape seed extract and the vitamin C are added to this mixture.

(5) The mixture thus obtained is then lubricated and compressed, before being coated with the film-coating agents and purified water.

Example 2

(6) A single-blind study was performed, on the basis of the composition of Example 1, under dermatological control, on 50 healthy women from 18 to 50 years old, having brittle/split nails.

(7) These women were supplemented for 3 months with the composition of Example 1, at a rate of two tablets per day. The efficacy of the supplementation was then validated by clinical scoring and self-evaluation.

(8) The results obtained are presented in the tables below.

(9) 1. Onychoschizia Clinical Scores

(10) TABLE-US-00002 TABLE 1 Mean T0 T1 month T2 months T3 months Lamellar 1.47 1.06 0.76 0.71 separation (1) Longitudinal 0.20 0.08 0.00 0.02 separation (2) Onychoschizia 1.67 1.14 0.76 0.73 score (1 + 2)

(11) The onychoschizia score decreases in a significant manner from 1 month of supplementation with the combination according to the invention, demonstrating the efficacy of the formulation on splitting of the nails.

(12) 2. Overall Clinical Efficacy Score

(13) The overall clinical score measures the change between times T0 and T1 month, T0 and T2 months and T0 and T3 months in the embrittled nature of the nail.

(14) This score is evaluated by means of a 5-point scale as indicated in the table below. The results are presented in terms of number and frequency.

(15) TABLE-US-00003 TABLE 2 T1 month T2 months T3 months 0 Deterioration  4%  2%  0% 1 No improvement 38% 21% 30% 2 Moderate 27% 42 % 39% 3 Good 31% 35% 29% 4 Excellent  0%  0%  2%

(16) From 1 month of supplementation with the combination in accordance with the invention, the clinician notes a marked improvement in the embrittled nature of the nail for 58% of the individuals.

(17) The improvement concerns 77% and 70% of the women after, respectively, 2 and 3 months of supplementation.

(18) 3. Self-Evaluation of the Quality of the Nails by the Individuals of the Study

(19) TABLE-US-00004 TABLE 3 T1 T2 T3 month months months Population % % % With the Entirely in agreement 4.1 24.5 24.5 supplementation, Quite in agreement 40.8 38.8 53 my nails split less Remotely in agreement 36.7 24.5 14.3 Not at all in agreement 18.4 12.2 8.2 No opinion 0 0 0 With the Entirely in agreement 2.0 8.2 16.3 supplementation, Quite in agreement 44.9 46.9 53.1 my nails crack less Remotely in agreement 38.8 34.7 30.6 Not at all in agreement 0 6.1 14.3 No opinion 0 4.1 0 With the Entirely in agreement 6.1 18.4 26.5 supplementation, Quite in agreement 42.9 42.9 49.0 my nails appear Remotely in agreement 32.7 26.5 20.4 to be less Not at all in agreement 18.4 8.2 4.1 damaged No opinion 0 4.1 0 With the Entirely in agreement 4.1 10.2 10.2 supplementation, Quite in agreement 40.8 44.9 55.1 my nails are Remotely in agreement 28.6 38.8 30.6 less brittle Not at all in agreement 16.3 16.3 4.1 No opinion 0 0 0 With the Entirely in agreement 4.1 12.2 14.3 supplementation, Quite in agreement 32.7 38.8 49.0 my nails are Remotely in agreement 40.8 30.6 28.6 less striated Not at all in agreement 16.3 12.2 6.1 No opinion 6.1 6.1 2.0 With the Entirely in agreement 10.2 20.4 22.4 supplementation, Quite in agreement 32.7 34.7 44.9 my nails are Remotely in agreement 34.7 32.7 28.6 more solid Not at all in agreement 20.4 10.2 4.1 No opinion 2.0 2.0 0 The food Entirely in agreement 4.1 8.2 16.3 supplement makes Quite in agreement 20.4 34.7 51.0 my nails shinier Remotely in agreement 32.7 34.7 30.6 Not at all in agreement 22.4 14.3 2.0 No opinion 20.4 8.2 0 The food Entirely in agreement 2.0 14.3 22.4 supplement makes Quite in agreement 26.5 32.7 40.8 my nails more Remotely in agreement 34.7 38.8 32.7 beautiful Not at all in agreement 18.4 14.3 2.0 No opinion 18.4 0 2.0

(20) The majority of the women participating in the study noted the efficacy of the combination in accordance with the invention.