BODY ILLUMINATION SYSTEM USING BLUE LIGHT

Abstract

The invention relates to a body illumination system comprising one or more light sources, said light sources being configured for emitting light in a wavelength range of 410-470 nm. The system is configured for exposing to said emitted light a surface area of 0.5-2.0 m.sup.2 of said body such that the power density of said emitted light on said surface area of said body is in the range of 20-120 mW/cm.sup.2, more preferably 30-100 mW/cm.sup.2. Alternatively, the system is configured for exposing to said emitted light a surface area of 10-60 cm′ of said body such that the power density of said emitted light on said surface area of said body is in the range of 10-30 mW/cm.sup.2. The body illumination system is for use in treating physical dysfunction, such as hypertension and erectile dysfunction.

Claims

1. A body illumination system comprising one or more light sources, said light sources being configured for emitting light in a wavelength range of 410-470 nm, preferably 430-470 nm, wherein said system is configured for exposing to said emitted light a surface area of 0.5-2.0 m.sup.2 of said body such that the power density of said emitted light on said surface area of said body is in the range of 20-120 mW/cm.sup.2, more preferably 30-100 mW/cm.sup.2.

2. The body illumination system according to claim 1, wherein said light sources are high power light-emitting diodes (LEDs).

3. The body illumination system according to claim 2, wherein said LEDs are arranged in modules, each module comprising a plurality of said LEDs.

4. The body illumination system according to claim 1, wherein said light sources have an optical power of 400-700 mW.

5. The body illumination system according to claim 1, further comprising a heat sink configured for transporting heat away from said light sources.

6. The body illumination system according to claim 1, further comprising a fan.

7. The body illumination system according to claim 1, further comprising a blood pressure sensor.

8. The body illumination system according to claim 1, further comprising at least one of a data transmitter and a data receiver configured for transmitting data from said body illumination system and receiving data at said body illumination system, respectively.

9. A body illumination system comprising one or more light sources, said light sources being configured for emitting light in a wavelength range of 420-470 nm, preferably 430-470 nm, wherein said system is configured for exposing to said emitted light a surface area of 10-60 cm.sup.2 of said body, such that the power density of said emitted light on said surface area of said body is in the range of 10-30 mW/cm.sup.2.

10. A method of treating a patient suffering from physical dysfunction comprising the step of exposing said person to light in a wavelength range of 410-470 nm, preferably 440-470 nm, to receive a therapeutically effective dose of said light.

11. The method according to claim 10, wherein said physical dysfunction is selected from hypertension and erectile dysfunction.

12. The method according to claim 10, further comprising the step of exposing said person to a system comprising a plurality of light sources for emitting said light, such that a surface area of 0.5-2.0 m.sup.2 of said person is exposed, wherein the power density of said emitted light on said surface area is in the range of 20-120 mW/cm.sup.2; more preferably 30-100 mW/cm.sup.2.

13. The method according to claim 10, further comprising the step of exposing the penis of said person to a system comprising a plurality of light sources for emitting said light, such that a surface area of 10-60 cm.sup.2 of said penis is exposed, wherein the power density of said emitted light on said surface area is in the range of 10-30 mW/cm.sup.2.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In the drawings:

[0021] FIGS. 1A-1C show schematic illustrations of a body illumination system according to various embodiments of the invention;

[0022] FIGS. 2A-2C show a schematic illustration of details of a body illumination system as shown in FIGS. 1A-1C;

[0023] FIGS. 3A-3C show in-vitro experimental results of the production of nitric oxide for LED light of different wavelengths; and

[0024] FIGS. 4A-4D show in-vitro experimental results of the toxic effects of human fibroblasts in dependence on the light wavelength, for different wavelengths, and the light dose.

DETAILED DESCRIPTION OF THE DRAWINGS

[0025] FIGS. 1A-1C provide schematic illustrations of a body illumination system 1. In FIG. 1A, a patient 2 lies on a bed 3 to be illuminated by the body illumination system 1. The body illumination system 1 comprises a plurality of light sources 4 configured for emitting light L on the patient 2 in a sunbed-like arrangement.

[0026] In FIG. 1B, two panels, oriented at an angle of 45° with respect to the bed 3, are provided that comprise light sources 4.

[0027] It should be appreciated that the light sources 4 are not necessarily provided over the entire body of the patient 2.

[0028] It should also be appreciated that the patient 2 is not necessarily on a bed. The body illumination system 1 may e.g. be comprised in a room R, the light sources 4 being accommodated in the walls of the room R, or being integrated in a standing system, as shown in FIG. 1C.

[0029] The body illumination system 1 comprises a control unit 5 containing a blood pressure sensor 6, a controller 7 and a data transceiver 8. It is noted that the control unit 5 may also be provided for the body illumination systems 1 of FIGS. 1B and 1C. The control unit 5 may comprise further modules, including e.g. a memory module for data storage.

[0030] The control unit 5 is configured for controlling the light sources 4 by means of the controller 7. The blood pressure sensor 6 is configured for measuring the blood pressure of the patient 2 when in contact with the body. Of course, a separate blood pressure sensor may also be used and the blood pressure may then be input into the body illumination system 1. The controller 7 may be triggered to activate the light sources (and, possibly, to set operating parameters of the light sources) by the result of the measurement of the blood pressure by the blood pressure sensor 6. Data collected by the control unit 5 may be transmitted to a remote external system 9 via the data transceiver 8. Also, the data transceiver 8 of the control unit 5 may receive data and/or control instructions from the remote system 9 for operating the body illumination system 1. Data transfer may be performed via a wired and/or a wireless network. The controller 7 may include a timer for programming or determining the operative time of the body illumination system 1.

[0031] The light sources 4 are preferably high power light-emitting diodes (LEDs). These LEDs 4 may be Luxeon® LEDs or Lumileds. The LEDs have an optical power in the range of 500-6500 mW and an electric power of 1.8-2.2 W. The number of LEDs may vary between 10 and 1,000, dependent on the application.

[0032] The drivers of the LEDs 4 may be provided in a separate unit (see e.g. FIG. 1A) or can be placed on the back side the LEDs.

[0033] For the treatment of physical dysfunction, in particular hypertension and erectile dysfunction, the light sources 4 emit blue light, thereby simultaneously reducing disadvantageous effects resulting from the use of UV light, as will be described in further detail with reference to FIGS. 3A-3C and 4A-4D. The wavelength of the emitted light L is in the range of 410-500 nm. In particular, a significant reduction of toxic effects may be obtained for wavelengths in the range of 425-470, 440-470 nm or even in the range of 450-465 nm.

[0034] The efficiency of the therapeutic treatment requires that a considerable surface area of the body is illuminated by the body illumination system 1. To that end, the body illumination system 1 should be configured such that it is capable of illuminating a surface area of 0.5-2.0 m.sup.2 for the treatment of hypertension. For erectile dysfunction, a surface area of 10-60 cm.sup.2 is sufficient. The efficiency of the therapeutic treatment is determined by the power density of the light L. For the treatment of hypertension, the power density of the emitted light L of the body illumination system 1 is in the range of 20-120 mW/cm.sup.2, 40-100 mW/cm.sup.2 or 50-80 mW/cm.sup.2. For the treatment of erectile dysfunction a power density in the same range may be applied. The lower limit of the power density is determined by the effectiveness of the treatment, while the upper limit is determined by the fact that the heat and light become unpleasant for a patient. A typical treatment time varies between 1 minute and 1 hour, such as 15 minutes.

[0035] Depending on the application, the distance between the LEDs 4 and the surface S of the patient 2 is in the range of 10 cm to 150 cm. For the treatment of hypertension, the distance is preferably in the range of 10 cm to 100 cm, in the range of 20 cm to 60 cm and even in the range of 25 cm to 55 cm, such as 40 cm. Treatment of erectile dysfunction may be obtained using smaller distances, e.g. in the range of 10-50 cm or 15-30 cm, such as 20 cm.

[0036] FIGS. 2A-2C show a schematic illustration of details of a body illumination system 1. FIG. 2A shows the body illumination system 1 comprising a channeled heat sink plate 10 in combination with a fan 11. The arrows indicate the air flow for cooling. FIG. 2B illustrates a cross-section of the body illumination system 1, whereas FIG. 2C illustrates a front view containing the LEDs 4. The LEDs 4 are provided in modules 12. LED drivers can be provided on the back side of these modules 12.

[0037] In particular, the LEDs 4 are mounted on printed circuit boards and are equipped with the heat sink plate 10. The heat sink plate comprises metal. The fan 11 is mounted on top of the heat sink plate 10 to provide effective heat removal by ventilation. FIGS. 3A-3C and FIGS. 4A-4D show in-vitro experimental results of blue light illumination of endothelial cells in nitride solutions with a pH of 5.5. These conditions are believed to correspond to the conditions existing in human skin.

[0038] In FIGS. 3A-3C, the horizontal axis is a time axis.

[0039] FIGS. 3A and 3B show a marked increase of nitric oxide (NO) production (vertical axis) immediately after switching on the light illumination system 1 using LEDs of 500-600 mW optical power and 1.8-2.2 W electric power at wavelengths of 410 nm and 420 nm, respectively. When the illumination system 1 is switched off, the NO production drops.

[0040] FIG. 3C illustrates the NO production for an illumination experiment with LEDs 4 at a wavelength of 450 nm. Again, the NO production is found to increase upon switching on the body illumination system 1, although less markedly than for wavelengths of 410 nm and 420 nm. The operating parameters of the body illumination system 1 were chosen such that no significant warming of the cells occurred.

[0041] In summary, the applicant has found that blue light, i.e. light outside the UV wavelength region, is capable of producing non-enzymatic nitric oxide from nitric solutions with a pH of 5.5.

[0042] FIGS. 4A-4D illustrate measurements as to the toxic effects of the blue light illumination for various doses of light (in J/cm.sup.2) along the horizontal axis. The vertical axis has arbitrary units, the value of which is set to 100 for a dose of 0 J/cm.sup.2, at other doses the measured value is relative to the value at 0 J/cm.sup.2. The toxic effect was measured by a cytotoxicity measurement. Treatment was considered not toxic if practically no or no died cells were counted during a cell count of living cells.

[0043] FIG. 4A illustrates reference measurements on a human skin fibroblast sample treated with light of 627 nm wavelength. Toxic effects were not observed up to a dose of 50 J/cm.sup.2.

[0044] FIGS. 4B and 4C illustrate measurements on a human skin fibroblast sample treated with light of 410 nm and 420 nm wavelength. Toxic effects were observed to depend on the illumination dose to which the sample is exposed.

[0045] FIG. 4D illustrates measurements on a human skin fibroblast sample treated with light of 450 nm wavelength. Surprisingly, no toxic effects were observed over the complete radiation dose range of 0-75 J/cm.sup.2.

[0046] Finally, it is noted that the patient may administer supplements in order to increase the efficiency of the light treatment. The use of supplements such as antioxidants in combination with light treatment is recommended, because of the protective effect on the NO radical and the maintenance of stability in the endothelial cell membranes. The antioxidants protect cells against the effects of free radicals produced during normal oxygen metabolism and reduce therefore the peroxidation reaction and the loss of free nitric oxide, the neurotransmitter, which relaxes the walls of the blood vessels. Antioxidant supplements that may be used include L-taurine and Selenium. L-taurine is an amino acid, found in eggs, dairy products, meat and fish proteins and in nutraceutical form. Selenium ensures that the endothelial cells will be free to produce maximal nitric oxide, resulting in improved cardiovascular health.