PULSED LASER SYSTEM FOR DERMATOLOGICAL TREATMENTS
20210268307 · 2021-09-02
Inventors
Cpc classification
A61B2017/0019
HUMAN NECESSITIES
A61B2017/00172
HUMAN NECESSITIES
International classification
Abstract
Disclosed is a pulsed laser system for dermatological treatment, including a light source suitable for emitting a light pulse beam and an optical amplifier system suitable for generating a laser pulse beam at a first repetition frequency. The duration of a laser pulse is between 100 femtoseconds and 100 picoseconds, the first repetition frequency is between 1 kHz and 10 GHz, each laser pulse having a quantity of energy less than or equal to 1 microjoule, and the pulsed laser system also includes a unit for temporally modulating the laser pulse beam and/or a unit for spatially modulating the laser pulse beam, the temporal and/or spatial modulation means being suitable for reducing the density of energy deposited on a surface to be treated and for generating a density of energy of between 0.0001 J/cm.sup.2 and 0.01 J/cm.sup.2.
Claims
1. A pulsed laser system for dermatological treatment, the pulsed laser system comprising a light source suitable for emitting a light pulse laser and an optical amplifier system suitable for receiving the light pulse beam and generating a laser pulse beam at a first repetition frequency (F.sub.1), wherein: the duration (d) of a laser pulse is between 100 femtoseconds and 100 picoseconds, the first repetition frequency (F.sub.1) is between 1 kHz and 10 GHz, each laser pulse having a quantity of energy lower than or equal to 1 microjoule, and the pulsed laser system further includes means for temporally modulating the laser pulse beam and/or means for spatially modulating the laser pulse beam, these temporal and/or spatial modulation means being adapted to reduce the density of energy deposited on a surface area to be treated and to generate a density of energy between 0.0001 J/cm.sup.2 and 0.01 J/cm.sup.2.
2. The system according to claim 1, wherein the means for temporally modulating the laser pulse beam comprise an acousto-optic modulator and an electric generator, the acousto-optic modulator being arranged at the output of the optical amplifier system, the electric generator being adapted to generate a radiofrequency signal applied to the electrodes of the acousto-optic modulator, the radiofrequency signal being adapted so that the acousto-optic modulator selects a burst of laser pulses.
3. The system according to claim 1, wherein the optical amplifier system includes an optical pumping device and a current-voltage source, and wherein the means for temporally modulating the laser pulse beam comprise an electric generator adapted to generate a radiofrequency signal applied to the current-voltage source of the optical pumping device, the radiofrequency signal being adapted so that the optical amplifier system generates a burst of laser pulses.
4. The system according to claim 2, wherein the electric generator is further adapted to temporally modulate the radiofrequency signal in such a way as to modulate in intensity the laser pulses of a burst of laser pulses.
5. The system according to claim 2, wherein a burst of laser pulses includes a number (N) of laser pulses between 100 and 1,000,000.
6. The system according to claim 1, wherein the means for spatially modulating the laser pulse beam comprise a beam scanning device, the beam scanning device being adapted to move the laser pulse beam on a region of interest of the surface area to be treated in such a way as to limit the density of energy deposited in the region of interest.
7. The system according to claim 6, wherein the beam scanning device is adapted to move the laser beam along two transverse axes.
8. The system according to claim 6, wherein the moving speed of the light beam in the region of interest is between 0.1 m/s and 10 m/s.
9. The system according to claim 1, further comprising an optical focusing system, the optical focusing system being adapted to focus the laser beam to a spot having a diameter lower than about 20 mm.
10. The system according to claim 1, wherein the light source and the optical amplifier system are adapted to emit the laser pulse beam at a wavelength between 700 nm and 10,600 nm.
11. The system according to claim 3, wherein the electric generator is further adapted to temporally modulate the radiofrequency signal in such a way as to modulate in intensity the laser pulses of a burst of laser pulses.
12. The system according to claim 3, wherein a burst of laser pulses includes a number (N) of laser pulses between 100 and 1,000,000.
13. The system according to claim 4, wherein a burst of laser pulses includes a number (N) of laser pulses between 100 and 1,000,000.
14. The system according to claim 2, wherein the means for spatially modulating the laser pulse beam comprise a beam scanning device, the beam scanning device being adapted to move the laser pulse beam on a region of interest of the surface area to be treated in such a way as to limit the density of energy deposited in the region of interest.
15. The system according to claim 3, wherein the means for spatially modulating the laser pulse beam comprise a beam scanning device, the beam scanning device being adapted to move the laser pulse beam on a region of interest of the surface area to be treated in such a way as to limit the density of energy deposited in the region of interest.
16. The system according to claim 4, wherein the means for spatially modulating the laser pulse beam comprise a beam scanning device, the beam scanning device being adapted to move the laser pulse beam on a region of interest of the surface area to be treated in such a way as to limit the density of energy deposited in the region of interest.
17. The system according to claim 5, wherein the means for spatially modulating the laser pulse beam comprise a beam scanning device, the beam scanning device being adapted to move the laser pulse beam on a region of interest of the surface area to be treated in such a way as to limit the density of energy deposited in the region of interest.
18. The system according to claim 7, wherein the moving speed of the light beam in the region of interest is between 0.1 m/s and 10 m/s.
19. The system according to claim 3, further comprising an optical focusing system, the optical focusing system being adapted to focus the laser beam to a spot having a diameter lower than about 20 mm.
20. The system according to claim 3, wherein the light source and the optical amplifier system are adapted to emit the laser pulse beam at a wavelength between 700 nm and 10,600 nm.
Description
DETAILED DESCRIPTION OF AN EXEMPLARY EMBODIMENT
[0025] The following description in relation with the appended drawings, given by way of non-limitative examples, will allow a good understanding of what the invention consists of and of how it can be implemented.
[0026] In the appended drawings:
[0027]
[0028]
[0029]
[0030]
[0031]
[0032]
[0033]
[0034]
DEVICE AND METHOD
[0035] In
[0036] Such a laser system generates a deposit of a quantity of energy per unit surface area, for a given time. This energy deposit is between 0.1 J/cm.sup.2 and 100 J/cm.sup.2, and generally of the order of 1 J/cm.sup.2 per laser pulse having a pulse duration from ˜500 ps to several nanoseconds. The duration of treatment of an area to be treated is generally between 5 minutes and 60 minutes. Different physical phenomena may be involved in this energy deposit range. For laser pulses 11 having a duration longer than a nanosecond (10.sup.−9 s), it is considered that the absorption of the laser pulse beam is linear and induces a photo-ablation of the tissues. For laser pulses 11 having a duration shorter than a nanosecond (10.sup.−9 s) and a density of energy of the order of 1 J/cm.sup.2, it is considered that the absorption of the laser pulse beam is non-linear and induces a photo-disruption of the tissues.
[0037] The present disclosure proposes different laser systems that use short or ultra-short laser pulses, having a duration d between about 100 femtoseconds and 100 picoseconds, and preferably shorter than 10 ps. According to the present disclosure, the laser system generates these short or ultra-short laser pulses at a first, high repetition frequency F.sub.1, between 1 kHz and 10 GHz. In other words, the short or ultra-short laser pulses have a first repetition period T.sub.1 between 100×10.sup.−15 s and 100×10.sup.−9 s. Each light pulse has a quantity of energy lower than or equal to 100 microjoules. Moreover, the laser system includes means for temporally modulating the laser beam and/or means for spatially modulating the laser beam, these temporal and/or spatial modulation means being adapted to reduce the density of energy deposited on the surface area to be treated.
[0038] Particularly advantageously, the laser system according to the present disclosure includes an optical system adapted to focus the laser beam to an area having a surface area of about 0.01 square millimetres, i.e. a surface area about 1000 times smaller than with a laser system for dermatological treatment according to the prior art.
[0039]
[0040] The laser pulse beam 20 has a wavelength generally between 700 nm and 10,600 nm. The duration d of the laser pulses 20 produced by the laser system is between 500 fs and 100 ps, and preferably shorter than 50 ps. The first repetition frequency F.sub.1 of the laser pulses produced is between 1 kHz and 10 Ghz.
[0041] The acousto-optic modulator 3 is connected to the electric generator 4. More precisely, the electric generator 4 is adapted to generate a radiofrequency signal 40 applied to the electrodes of the acousto-optic modulator 3. The acousto-optic modulator 3 receives the laser pulse beam 20 and produces a temporally modulated laser pulse beam 100.
[0042] According to a first example of the first embodiment, the electric generator 4 is adapted to generate a door-shaped or rectangular radiofrequency signal 40, having a duration T.sub.3 longer than the first repetition period T.sub.1. The first repetition period T.sub.1 is equal to the inverse of the first repetition frequency F.sub.1: T.sub.1=1/F.sub.1. Hence, the acousto-optic modulator 3 selects a plurality of laser pulses forming a macro-pulse, also called pulse burst. Thus, the acousto-optic modulator blocks the laser pulses for a duration T.sub.4 longer than the first repetition period T.sub.1. This temporal modulation of the laser pulses makes it possible to limit the density of energy deposited on the surface area to be treated. Preferably, the so-deposited density of energy is lower than 0.01 J/cm.sup.2 on a focused spot having a diameter between 10 μm and 20 mm, and preferably lower than ˜1 mm.
[0043] The duration T.sub.3 of a macro-pulse is equal to the product of the number N of laser pulses in a macro-pulse by the first repetition period T.sub.1 of the laser pulses. Each laser pulse of the macro-pulse has a quantity of energy lower than or equal to 1 microjoule.
[0044] Optionally, the acousto-optic modulator 3 is adapted to sequentially generate several macro-pulses. The acousto-optic modulator can be adapted to generate a plurality of macro-pulses with a second repetition period T.sub.2. The second repetition period T.sub.2 is equal to the sum of the duration T.sub.3 of a rectangle and the duration T.sub.4 between two consecutive rectangles. In other words, the radiofrequency signal 40 is zero for the duration T.sub.4. The selection of duration T.sub.3 and duration T.sub.4 makes it possible to modulate the duration T.sub.2 of a macro-pulse and the repetition frequency of the macro-pulses, herein denoted second repetition frequency F.sub.2=1/T.sub.2. That way, the acousto-optic modulator makes it possible to reduce the number of laser pulses incident on the surface area to be treated and to modulate the density of energy deposited.
[0045]
[0046] According to a variant, the electric generator 4 produces a radiofrequency signal 40 that is modulated in intensity for a duration T.sub.3 and zero for a duration T.sub.4. More precisely, for a duration T.sub.3, the radiofrequency signal 40 is increasing then decreasing. For example, the radiofrequency signal 40 has a triangular shape for the duration T.sub.3. Optionally, the radiofrequency signal 40 is periodic with a second repetition period T.sub.2 equal to the sum of duration T.sub.3 and duration T.sub.4. As illustrated for example in
[0047] According to another alternative, the electric generator 4 produces a radiofrequency signal 40 that is modulated in intensity for a duration T.sub.3 and zero for a duration T.sub.4. More precisely, in this other alternative, for a duration T.sub.3, the radiofrequency signal 40 is increasing then constant then decreasing. For example, the radiofrequency signal 40 has a trapezoidal shape for the duration T.sub.3. Optionally, the radiofrequency signal 40 is periodic with a second repetition period T.sub.2, equal to the sum of duration T.sub.3 and duration T.sub.4. As illustrated for example in
[0048] According to a second embodiment, the laser system has no acousto-optic modulator but contains an electric generator 14. The optical amplifier 2 includes an optical pumping device 12, for example one or several single-mode or multi-mode laser diodes, or also one or several flash lamps. The electric generator 4 is connected to the current-voltage source of the optical pump device. More precisely, the electric generator 14 is adapted to generate a radiofrequency signal 41 applied to the current-voltage source of the optical pumping device. The optical amplifier 2 receives the light pulse beam 10 from the oscillator and generates a temporally modulated laser pulse beam 150. Thus, the electric generator 14 makes it possible to directly modulate the light intensity of the pulses amplified by the optical amplifier 2.
[0049] According to a first example of this second embodiment, the electric generator 14 produces an intensity-modulated radiofrequency signal 41, for example of rectangular shape, non-zero for a duration T.sub.3, the radiofrequency signal 41 being zero for a duration T.sub.4. Thus, in this first example, for the duration T.sub.3, the radiofrequency signal 41 is constant. Optionally, the radiofrequency signal 41 is periodic with a second repetition period T.sub.2, equal to the sum of duration T.sub.3 and duration T.sub.4. As illustrated for example in
[0050] According to a first alternative of this second embodiment, the electric generator 14 produces an intensity-modulated radiofrequency signal 41, for example of triangular shape for a duration T.sub.3, the radiofrequency signal 41 being zero for a duration T.sub.4. Thus, in this alternative, for the duration T.sub.3, the radiofrequency signal 41 is increasing then decreasing. Optionally, the radiofrequency signal 41 is periodic with a second repetition period T.sub.2. As illustrated for example in
[0051] According to another alternative of this second embodiment, the electric generator 14 produces an intensity-modulated radiofrequency signal 41, for example of trapezoidal shape for a duration T.sub.3, the radiofrequency signal 41 being zero for a duration T.sub.4. Thus, in this alternative, for the duration T.sub.3, the radiofrequency signal 41 is increasing then decreasing. Optionally, the radiofrequency signal 41 is periodic with a second repetition period T.sub.2. As illustrated for example in
[0052] The person skilled in the art will easily adapt the shape and durations T.sub.3 and T.sub.4 of the radiofrequency signal 40 or 41 to obtain the light intensity modulation of the laser pulses as a function of the application and the dermatological treatment considered.
[0053] This second embodiment makes it possible to modulate the pump signal of the optical amplifier to select a plurality of laser pulses forming a macro-pulse, in such a way as to limit the density of energy deposited by the laser beam to less than 0.01 J/cm.sup.2.
[0054] Due to the limited energy of the laser pulse beam, the present disclosure makes it possible to focus the laser beam on a smaller surface area. The spot is hence 1000 times smaller than a laser spot generated by a dermatological laser system of the prior art. Instead of covering a surface area of a few square millimetres, the laser beam then covers only a surface area of about 0.01 square millimetres, i.e. a laser beam focused on a disk having a diameter of about 50 to 100 micrometres. However, certain dermatological treatments must be performed on large surface area, of several square centimetres to a few tens of square centimetres. The use of a laser spot having a diameter lower than about a tenth of mm can take a significant amount of time, which is a priori dissuasive.
[0055] However, according to the present disclosure, a first repetition frequency F.sub.1 is used, which is 10,000 to 100,000 times higher than the repetition frequency F of a laser system of the prior art. The use of a laser system of very high repetition frequency F.sub.1 makes it possible to obtain a cumulative effect on the treated surface area and to induce a non-linear photo-disruptive effect. In other words, the laser system of the present disclosure operates in a new regime. Indeed, in this new regime, each individual pulse has not the sufficient energy or light intensity to produce optical ruptures of the photo-disruptive type. However, thanks to the non-linear processes, the cumulative interactions of a plurality of laser pulses at the first repetition frequency F.sub.1 induce structural changes in the materials, entailing an improvement of the absorption. After a determined number of pulses, which depends on the surface area to be treated and on a light intensity threshold, a photo-disruption phenomenon occurs. The major interest of this new effect is linked to the fact that the density of energy deposited on the skin is limited and preferably lower than or equal to 0.01 J/cm.sup.2, which makes it possible to preserve the surface area treated in dermatology from undesirable phenomena of ablation and overheating.
[0056] The cumulative interaction of a series of N microjoule-energy laser pulses at a first high repetition frequency F.sub.1 makes it possible to obtain a selective photo-disruptive effect as a function of the concerned target, non-limitatively chosen, for example, among endogenous pigments, exogenous pigments, melanin or sebum.
[0057] According to a third embodiment, which can be implemented separately from or in combination with the first or the second embodiment, the laser system includes an oscillator 1, an optical amplifier system 2, and further includes a beam scanning device 5, also called a scanner. An electric control and synchronization system 6 is connected to the beam scanning device 5. The beam scanning device 5 is arranged at the output of the laser chain, herein at the output of the optical amplifier system 2. By way of non-limitative example, the beam scanning device 5 includes a scanner with two transverse axes. Such a beam scanning device 5 makes it possible to move the laser beam along two transverse directions on the surface area to be treated. The electric control and synchronization system 6 generates an electric or electronic signal 60 that makes it possible to control the moving orientation, direction and speed on each axis of the beam scanning device 5.
[0058] The electric control and synchronization system 6 and the beam scanning device 5 are configured to move the laser beam on the surface area to be treated in such a way as to limit the density of energy deposited, preferably to less than 0.01 J/cm.sup.2. As a function of the moving speed, it is thus possible to modify the quantity of energy deposited per unit surface area for a given time, i.e. to modulate the density of energy deposited on the treated surface area.
[0059]
[0060] The treatment is started, for example, by applying a laser spot 200 on the top left of the surface area to be treated 80. The beam scanning device 5 moves the laser beam along the axis X with a first moving speed V1. Arrived near the edge of the surface area to be treated 80, the beam scanning device 5 applies a move along axis Y and changes the direction along axis X while keeping the first moving speed V1. Arrived near the other edge of the surface area to be treated 80, the beam scanning device 5 applies a move along axis Y and changed the direction along axis X, while applying a second moving speed V2 higher than V1. Arrived near the edge of the surface area to be treated 80, the beam scanning device 5 applies a move along axis Y and changes the direction along axis X, while keeping the second moving speed V2. The moving speeds may reach 8 m/s, which makes it possible to cover the surface area to be treated 80 of 1 cm.sup.2 for a spot of 1 mm within ˜13 ms.
[0061] The moving speed determines the number of cumulated high-rate pulses and hence makes it possible to determine the quantity of energy deposited per unit surface area for a given time. Hence, the density of energy deposited is higher in the area in which the beam is moved at speed V1, by comparison with the area of the surface area to be treated in which the beam is moved at speed V2.
[0062] The moving speed along axis X or Y is generally between 0.1 m/s and 10 m/s, and preferably higher than 5 m/s.
[0063] The laser beam may be moved continuous or step by step.
[0064] The third embodiment makes it possible to spatially modulate the density of energy of a low-energy laser pulse beam having a high repetition period F.sub.1, so as to strongly reduce the density of energy deposited. This third embodiment hence makes it possible to reach the cumulative photo-disruption non-linear interaction regime.
[0065] According to a particular embodiment, the laser system combines a temporal modulation of the laser pulses into macro-pulses, as described in relation with the first or the second embodiment, and a laser spot move on the area to be treated as described in relation with the third embodiment. This combination of a temporal and spatial modulation of the laser pulse beam makes it possible to increase the dynamics of adjustment of the density of energy that is deposited. It also makes it possible to improve the spatial resolution of the laser beam without increasing the total duration of the laser treatment for a given surface area.
[0066] A single laser system combining an acousto-optic modulator and a beam scanning device 5 makes it possible to modulate both temporally and spatially the density of energy of the high repetition frequency and low energy laser pulses over a very wide dynamics.
[0067] Still more simply, a single laser system combining an optical amplifier system and a beam scanning device 5, in which an electric RF signal generator is connected to the current-voltage source of the optical pump device of the optical amplifier system makes it possible to modulate both temporally and spatially the density of energy of the high repetition frequency and low energy laser pulses over a very wide dynamics.
[0068] A single laser system combining the first and the third embodiments or the second and third embodiments hence makes it possible to perform a varied range of dermatological treatments, which previously required several laser systems.
[0069] The laser system according to the present disclosure operates in a new interaction regime, herein called cumulative photo-disruption of the tissues, which is based on the use of a number N of laser pulses, preferably ultra-short, of low energy, high repetition frequency, and on a temporal and/or spatial modulation of the laser beam to limit the density of energy deposited on the surface area to be treated.
[0070] The invention makes it possible to focus the beam on spot of very small size, which allows a better targeting of the area to be treated. The spatial covering of the area to be treated is obtained by moving the laser beam, preferably by means of a beam scanning device. This beam scanning can be adjusted as a function of the contours of the surface area so as to apply the laser beam on the whole surface area to be treated 80 without going over the lines about this surface area to be treated.