NEEDLELESS INJECTION SYSTEM

Abstract

Needleless injection system (150) for injecting a composition, the system (150) comprising and/or designed to receive a reservoir (102) containing a pressurized gas, notably stored in gaseous and/or liquefied form, the system (150) comprising conveying ducts (306; 306a; 306b), enabling the gas to be directed, first, towards the human keratin materials in order to cool said materials by means of the cold generated by an expansion of the pressurized gas and/or towards a surface (340) configured such as to capture the cold generated by an expansion of the pressurized gas and to transmit it towards the human keratin materials in order to cool the human keratin materials, and, second, towards a mechanism (308; 309; 10; 9) for propelling the composition into the human keratin materials using the gas pressure.

Claims

1. A needleless injection system for injecting a composition, the system comprising and/or designed to receive a reservoir containing a pressurized gas, stored in gaseous and/or liquefied form, the system comprising conveying ducts, enabling the gas to be directed, first, towards the human keratin materials in order to cool said materials by means of the cold generated by an expansion of the pressurized gas and/or towards a surface configured such as to capture the cold generated by an expansion of the pressurized gas and to transmit it towards the human keratin materials in order to cool the human keratin materials, and, second, towards a mechanism for propelling the composition into the human keratin materials using the gas pressure.

2. The system according to claim 1, comprising a hand piece comprising and/or designed to receive the reservoir containing the pressurized gas.

3. The system according to claim 1, comprising a thermal pad cooled by the cold generated by the expansion of the pressurized gas and configured such as to come lean on the human keratin materials.

4. The system according to claim 3, the thermal pad being of annular form and injection being carried out through said pad.

5. The system according to claim 3, comprising at least one thermal bridge within or in contact with which the pressurized gas expands, the or each thermal bridge being configured such as to convey the cold generated by the expansion of the pressurized gas to the thermal pad.

6. The system according to claim 1, the composition being a pulverulent phase, such as a loose powder, or a loose powder in a gaseous phase.

7. The system according to claim 1, the composition being liquid and comprising a liquid phase, a mixture of a liquid phase and of a pulverulent phase, a mixture of a liquid phase and of a gaseous phase, or a mixture of a liquid, a pulverulent and a gaseous phase, the composition having, at least at the moment of its injection, a viscosity greater than or equal to 1 mPa.Math.s at 25° C. and atmospheric pressure.

8. The system according to claim 7, the composition comprising a dispersion of particles in a liquid medium, it being possible for said composition to solidify via the aggregation of said particles.

9. The system according to claim 8, the composition comprising at least one biopolymer, and an ionic solution.

10. The system according to claim 1, wherein a quantity of the composition being is located within a first chamber between a first piston and a gas buffer.

11. The system according to claim 1, the composition comprising at least one filler selected from a biopolymer, hydroxyapatite particles, polylactic acid, an alginate, sodium monomethyltrisilanol orthohydroxybenzoate, collagen, an acrylic polymer, a methacrylic polymer and/or dextran microspheres.

12. The system according to claim 1, comprising a regulation and control system configured to deliver pulses of gas into the conveying ducts, the regulation and control system comprising means for regulating and controlling the pressure, flow rate, duration and/or frequency of the pulses of gas delivered, the regulation and control system making it possible selectively to trigger the injection of the composition into the human keratin materials and/or to cool the human keratin materials and/or the regulation and control system being configured such as to allow triggering of a single injection of the composition into the human keratin materials or of one sequence or of a plurality of sequences of a plurality of successive injections.

13. A method for the non-therapeutic, cosmetic treatment of human keratin materials, comprising: a) providing a needleless injection system comprising a composition to be injected and a reservoir containing a pressurized gas, according to claim 1, b) placing the needleless injection system close to the human keratin materials to be treated, c) generating cold by means of an expansion of the pressurized gas, d) ejecting outside of the needleless injection system, notably delivering into said human keratin materials, a quantity of the composition to be injected by using the pressure of the gas, the ejection of said quantity of the composition outside of the needleless injection system being carried out as a single ejection or as one sequence or as a plurality of sequences of a plurality of successive injections, and e) cooling said human keratin materials by means of the cold generated by the expansion of the pressurized gas.

14. The method according to claim 13, wherein step e) is performed before and/or during step d), or step e) is performed after step d).

15. The method as claimed in claim 13, comprising the following steps: i. intaking a quantity of the composition to be injected into a first chamber under a first piston, ii. raising of the first piston into the first chamber to draw in ambient air via an opening in an outlet channel of an injection nozzle so as to form an air buffer in the first chamber under the composition present within the first chamber, and iii. lowering of the first piston in the first chamber (5) such as to eject the composition present within the first chamber outside of the needleless injection system through the opening in the outlet channel of the injection nozzle.

16. The method according to claim 13, wherein the human keratin materials being are cooled by at least 3° C., relative to their initial temperature.

Description

[0141] The invention may be better understood from reading the following detailed description of non-limiting exemplary embodiments thereof and from studying the appended drawing, in which:

[0142] FIG. 1 schematically shows a perspective view of an example of a needleless injection system according to the invention,

[0143] FIG. 2 is a view similar to FIG. 1,

[0144] FIG. 3 is a longitudinal section on plane III in FIG. 1,

[0145] FIG. 3A shows a detail from FIG. 3, without the valve,

[0146] FIG. 4 schematically shows an example of an injection system according to the invention,

[0147] FIG. 5 schematically shows a perspective view of an example of a cartridge comprising a composition to be injected according to the invention,

[0148] FIG. 6 is a longitudinal section on plane A in FIG. 5,

[0149] FIG. 7 is a view similar to FIG. 6, without the push rod, and

[0150] FIG. 8 shows an embodiment detail of the injection system.

[0151] FIG. 1 shows an example of a needleless injection system 150 according to the invention.

[0152] This system 150 extends generally along an axis X of elongation. It comprises an injection device 100 and a cartridge 1 comprising the composition to be injected.

[0153] The cartridge 1 comprises a first chamber 5 designed to receive the composition to be injected, an injection nozzle 6 communicating with the first chamber 5 and at least one second chamber 7 containing the composition to be injected and communicating with the first chamber 5 via at least one supply duct 8 via which the first chamber 5 is supplied with the composition contained in the second chamber 7.

[0154] The or each supply duct 8 comprises a shut-off member 12, which is, for example, a ball. The latter may close off the supply duct 8 during injection.

[0155] The system 150 preferably comprises a hand piece 300 made from a thermoplastic material, notably a polycarbonate-based material.

[0156] The hand piece 300 may be given various forms.

[0157] Preferably, the hand piece 300 has an elongate form to make it easier to hold in the hand and to manipulate.

[0158] The system 150 comprises a reservoir containing a pressurized gas. The reservoir may be a gas cartridge 102.

[0159] If desired, a compact injection system 150 may be used, incorporating the gas cartridge 102 into the hand piece 300, as illustrated in FIG. 1. The handpiece may then comprise a housing 105 for receiving the cartridge 102.

[0160] The cartridge 102 may be removable and replaceable. It may or may not be refillable. Preferably, the gas cartridge 102 contains liquefied CO2.

[0161] Preferably the cartridge 102 is compact. It has, for example, a gas mass of less than 50 g, for example 12 g or 16 g, a length of less than 10 cm and a diameter of less then 2 cm.

[0162] The cartridge 102 may contain a quantity of gas sufficient to perform a number of injections in excess of or equal to 100. Such autonomy may allow treatment of all facial wrinkles.

[0163] The pressure within the cartridge 102 is, for example, greater than 25 bar, and, better, greater than 50 bar.

[0164] The system 150 may comprise at least one thermal bridge 302 within which the pressurized gas expands. This thermal bridge 302 is configured such as to convey the cold generated by the expansion of the pressurized gas to a thermal pad 304 configured such as to come into contact with human keratin materials. This thermal pad 304 may be of annular form, injection being carried out through the pad.

[0165] The or each thermal bridge 302 may comprise a hollow body 302a extending via a rod 302b coming into contact with the thermal pad 304, as illustrated in FIG. 1. In a variant, the element 302b is a ring.

[0166] Preferably, the or each hollow body 302a is located in the hand piece 300.

[0167] The system 150 may comprise a connection and distribution interface 301 comprising a connector 305 making it possible to place the outlet from the gas cartridge 102 in communication with a plurality of conveying ducts 306 arranged in parallel with the longitudinal axis of the injection system 150, as illustrated in FIG. 3.

[0168] Preferably, the connection and distribution interface 301 is located in the hand piece 300.

[0169] The gas cartridge 102 is configured such as to connect removably to the inlet of the connection and distribution interface 301, notably by means of screw-fastening or bayonet-fixing. Preferably, this connection is achieved rapidly and securely, without tools. The inlet of the interface 301 may comprise an O-ring that guarantees the leaktightness of the connection. When the cartridge 102 is closed by a film that can be pierced, the inlet of the interface 301 may comprise a needle for piercing this film.

[0170] As illustrated in FIG. 3, the or each conveying duct 306 may comprise a branching 306a that makes it possible to convey a portion at least of the gas contained in the cartridge 102 towards an actuation chamber 308. This chamber 308 receives a thrust element 309 connected to a head 10b of a push rod 10. Pressurizing of the chamber 308 enables injection to be performed by actuating the thrust element 309, the push rod 10 and a first piston 9 located in the extension of the rod 10.

[0171] The thrust element 309 and/or the push rod 10 may comprise at least one elastic return member (not shown) configured such as to assist in their movement in the course of injection or, alternatively, to damp their movement or to assist the thrust element 309 and/or the push rod 10 in returning to their initial position after injection.

[0172] The or each conveying duct 306 may also comprise a duct 306b received within the hollow body 302a in order to convey a portion at least of the gas contained in the cartridge 102 towards a discharge area 307 located within the thermal pad 302. This area 307 may be located opposite the rod or ring 302b.

[0173] The duct 306b comprises an opening in the discharge area. This makes it possible to promote a high-speed gaseous stream at the opening and hence more significant cooling generated by the expansion of the gas.

[0174] The discharge area 307 has a surface 340 configured such as to capture the cold generated by the expansion of the pressurized gas at the opening of the duct 306b. This surface 340 may be located close to and/or opposite the opening of the duct 306b.

[0175] The injection device 100 comprises a propulsion mechanism that may comprise the actuation chamber 308, the thrust element 309, the push rod 10 and the first piston 9.

[0176] As illustrated in FIG. 4, the injection system 150 may comprise an injection device 100 and a cartridge 1 containing the composition to be injected. The injection device 100 may comprise a regulation and control system 140 comprising, for example, at least one valve and/or at least one pressure-reducing valve. This control system 140 may make it possible to control the connection and distribution interface 301 and, notably, to allow the delivery of pulses of gas into the conveying ducts 306. The control system 140 may make it possible to regulate parameters such as pressure, flow rate, duration and frequency of the pulses of gas.

[0177] The regulation and control system 140 may comprise a manually or electrically controlled valve 310 allowing a supply to the branching 306a of the propulsion mechanism and a supply to the duct 306b of the discharge system. This makes it possible to cool and to inject concomitantly. In a variant, the branching 306a may be supplied separately from the duct 306b. This makes it possible to obtain a configuration that allows cooling only or a configuration that allows injection only.

[0178] The valve 310 may be controlled by user action on a control member, such as a push button (not shown), for example, it being possible for such a member to be located on the hand piece 300.

[0179] In the configuration that allows cooling only, the valve 310 is configured such as to supply solely the duct 306b of the discharge system with a portion at least of the gas contained in the cartridge 102. The expansion of a portion at least of the gas contained in the cartridge 102 then takes place right along the duct 306b up to the discharge area 307. This expansion makes it possible to generate cold, notably in the discharge area 307. This cold is transmitted to the thermal bridge 302, notably to the hollow body 302a receiving the duct 306b and to the area of the rod or ring 302b opposite the discharge area 307. The thermal bridge 302 conveys the cold to the thermal pad 304. This configuration may make it possible to cool human keratin materials before and/or after injection.

[0180] In the configuration that allows cooling only, the valve 310 is configured such as to supply solely the branching 306a of the propulsion mechanism with a portion at least of the gas contained in the cartridge 102.

[0181] In the configuration that allows cooling and injection concomitantly, the valve 310 is configured such as simultaneously to supply the duct 306b and the branching 306a with a portion at least of the gas contained in the cartridge 102. The flow rate and/or the pressure of gas in the duct 306b and the branching 306a may or may not be identical.

[0182] In a variant, the regulation and control system 104 does not comprise a valve 310, as illustrated in FIG. 3A. The gas originating from the cartridge 102 is then directed into both the branching 306a and the duct 306b. The flow rate and/or the pressure of gas exiting the cartridge 102 are chosen such that the flow rate and/or the pressure of gas in the branching 306a are sufficient to actuate the propulsion mechanism. This enables cooling and injection to take place concomitantly, without control by a valve 310.

[0183] Injection of the composition into the human keratin materials and/or the cooling of the human keratin materials may be controlled by user action on a control member, such as a push button (not shown), for example, it being possible for such a member to be located on the hand piece 300.

[0184] The regulation and control system 140 may be configured such that user action on the control member triggers a single injection or, in a variant, one or a plurality of sequences of a plurality of successive injections. Injections may thus be carried out one by one or as a burst. The regulation and control system 140 may make it possible to regulate parameters such as the number and frequency of injections in the course of the sequence, the duration of the sequence and, if appropriate, the number of sequences and the period of time between each sequence.

[0185] Similarly, the regulation and control system 140 may be configured such that user action on the control member triggers a single expansion of pressurized gas in order to generate cold or, in a variant, one or a plurality of sequences of a plurality of successive expansions.

[0186] The control system 140 may be electrically connected to a power supply 160. The role of the power supply 160 is to provide electrical energy to the control system in order that the latter can function. The power supply 160 may be a fuel cell or a battery, notably a rechargeable fuel cell or battery, a mains power supply, or any other source of electrical power.

[0187] The expansion of the pressurized gas contained in the cartridge 102 may allow actuation of the push rod 10 in order forcibly to expel the composition contained in the first chamber 5 into the keratin materials and, where appropriate, pushing of the reserve of composition contained in the second chamber 7 towards the first chamber 5 in order to refill the latter. The injection device 100 may comprise the push rod 10. In a variant, the latter is present in the cartridge 1.

[0188] Expansion of the pressurized gas contained in the cartridge 102 may also make it possible to generate cold within the thermal bridge 302, this cold being transmitted by conduction to the thermal pad 304. The cartridge 1 may comprise a portion at least of the or of each thermal bridge 302 and, notably, a portion at least of the rod or ring 302b of the or of each thermal bridge 302, as illustrated in FIGS. 6 and 7.

[0189] The connection and distribution interface 301, the or each conveying duct 306, the or each thermal bridge 302 and the thermal pad 304 at least are preferably made from a material exhibiting good heat-conducting properties.

[0190] The injection system 150 may comprise a removable, replaceable cartridge comprising the composition to be injected and located in the extension of the hand piece 300. In a variant, the cartridge is not removable or replaceable.

[0191] FIG. 5 shows an example of a cartridge 1 that extends generally along an axis X of elongation. To simplify FIG. 5, a portion at least of the rod or ring 302b of the or each thermal bridge 302 has not been shown.

[0192] The cartridge 1 is configured to come into contact with and, notably, to be inserted into the injection device 100. The cartridge 1 may be fixed to the injection device 100 by any means.

[0193] The cartridge 1 comprises a body 2 that has a cylindrical portion 2a with an opening 3a at an end 3.

[0194] The cylindrical portion 2a extends at the opposite end from the end 3 in the form of a frustoconical portion 2b forming the injection nozzle 6. The cartridge 1 is configured such as to be mounted on an injection device, which is not shown in FIG. 5. The injection nozzle 6 has an outlet channel 6a and an end face 6b to be positioned facing or in contact with the human keratin materials to be treated.

[0195] The cartridge 1 comprises some at least of the rods or rings 302b of the thermal bridges 302 (shown in transparent form in FIG. 6 in order to make it easier to understand the figure), these coming into contact with the thermal pad 304.

[0196] The cartridge 1 also comprises the first chamber 5 designed to receive the composition to be injected. The channel 6a of the injection nozzle 6 communicates with this first chamber 5.

[0197] The second chamber 7, containing the reserve of composition, communicates with the first chamber 5 via at least the supply duct 8.

[0198] In the example illustrated, the first chamber 5 occupies a central position in the cartridge 1 and has a cylindrical first portion 5a, of cross section S1, and a cylindrical second portion 5c, of cross section S2 smaller than the cross section S1. The first and second portions 5a and 5c are connected by an intermediate portion 5b that converges towards the distal end of the cartridge 1. The first chamber 5 has a distal portion 5d of which the wall converges towards the distal end of the cartridge 1, this portion 5d forming the end wall of the first chamber 5. The latter may, as illustrated, have a circular cross section over its entire length.

[0199] The volume of the first chamber 5 is, for example, greater than or equal to 50 mm.sup.3.

[0200] The outlet channel 6a may have a constant cross section, for example a circular cross section, along its entire length.

[0201] In a variant, the injection nozzle 6 comprises a plurality of outlet channels 6a, each being connected to the end wall 5d of the first chamber 5 and each opening out at the end of the nozzle via a corresponding opening 6c.

[0202] The opening 6c of the or each outlet channel 6a of the injection nozzle 6 may be covered before first use by a removable film (not shown) that adheres to the end of the injection nozzle 6. This film ensures that the composition contained in the cartridge 1 is preserved and remains sterile.

[0203] The cross section of the opening 6c of the or each channel 6a of the nozzle 6 is, for example, smaller than or equal to 0.5 mm.sup.2, in particular between 0.1 and 0.2 mm.sup.2.

[0204] The first chamber 5 receives the first piston 9 of which the distal end 9a has a conical form that complements that of the end wall 5d of the first chamber 5. This first piston 9 may be made from an elastomeric material.

[0205] The first piston 9 presses in a sealed manner against the internal surface of the portion 5c of the first chamber 5 and may have one or a plurality of annular sealing lips, for example two lips 9b and 9c as illustrated.

[0206] The cartridge 1 may comprise the push rod 10 of which the distal end 10a is fixed by clip-fastening, screw-fastening, friction and/or any other means to the first piston 9. At its proximal end the rod 10 comprises the head 10b configured such as to collaborate with a drive system of the injection device.

[0207] The cartridge 1 is arranged in such a way that the first piston 9 slides within the first chamber 5 along the longitudinal axis thereof, driven by the push rod 10.

[0208] In a variant, the cartridge 1 does not comprise a first piston 9 or push rod 10, as illustrated in FIG. 7. The first piston 9 may then be fixed to the distal end 10a of the push rod 10. The opening of the first chamber 5 at the proximal end 3 of the cartridge 1 may be covered prior to first use by a removable film (not shown) that adheres to the proximal end 3 of the cartridge 1. This film ensures that the composition contained in the cartridge 1 is preserved and remains sterile.

[0209] The second chamber 7 may be of annular form and extend around the first chamber 5, as illustrated. Preferably, the volume of the second chamber 7 is greater than that of the first chamber 5. The volume of the second chamber 7 is, for example, greater than or equal to 100 mm.sup.3.

[0210] The second chamber 7 communicates with the first chamber 5 via the supply duct 8. The latter may be perpendicular to the axis of the chamber 5, as illustrated, or angled upwards or downwards.

[0211] This duct 8 is equipped with a valve 11 that opens in the direction of flow of the composition from the second chamber 7 to the first chamber 5. This valve has no spring for returning the shut-off member 12, in this instance constituted by a ball, to rest.

[0212] In a variant, the second chamber 7 communicates with the first chamber 5 via a plurality of supply ducts 8. This allows better transfer of the composition from the second chamber 7 to the first chamber 5, notably faster transfer.

[0213] The second chamber 7 is closed at one of its ends by a second piston 14 that in the example considered is of annular form. This second piston 14 presses in a sealed manner against the interior wall 7a of the second chamber 7. It may have one or a plurality of sealing lips 14a and 14b.

[0214] The second piston 14 may be driven by any means in the direction of an emptying of the second chamber 7.

[0215] The first chamber 5, the second chamber 7, the injection nozzle 6 and the supply duct 8 may be formed within a one-piece component. In a variant, they are formed by an assembly of a plurality of components.

[0216] The cartridge 1 may be made from a thermoplastic material, notably a polycarbonate-based material. The elements of the cartridge 1 that are in contact with the composition to be injected, notably the wall of the first chamber 5, of the second chamber 7, of the supply duct 8 and of the outlet channel 6a, may be covered with glass, notably silicone glass and/or depyrogenated glass.

[0217] In a variant, if the viscosity of the composition so permits, the radially exterior wall 20 of the cartridge 1 is made from a deformable flexible material. This then allows the user to supply the first chamber 5 with the composition contained in the second chamber 7 by applying pressure, for example finger pressure, to the wall 20.

[0218] In another variant, the cartridge comprises a visual indicator of the fill level of the composition contained in the second chamber 7, for example a transparent window made in the wall 20.

[0219] The cartridge may be specifically dedicated to one application in particular, notably to the treatment and/or prevention of folds on the surface of the skin, for example folds in the labionasal area (also referred to as smile lines), in the crow's feet area, in the area between the eyebrows and/or in the forehead area. The cartridge may be dedicated to use on fine lines, surface wrinkles and/or deep wrinkles.

[0220] The nature of the active compound present in the composition to be injected, and the volumes and dimensions of the first chamber and second chamber and of the injection nozzle are tailored to suit the target application and the physical/chemical properties of the composition, such as particle size distribution when the composition is a loose powder or viscosity when the composition is liquid.

[0221] In a variant, the cartridge 1 comprises a plurality of second chambers. Each second chamber communicates with the first chamber via at least one supply duct. Each second chamber may be of tubular form and be arranged on the exterior of the first chamber, being closed at its proximal end by a corresponding second piston. These second chambers may all contain the same composition to be injected. In a variant, the second chambers contain different compositions. This makes it possible for one and the same cartridge 1 to be used in a plurality of applications. If appropriate, at least one of the second chambers contains a cleaning product instead of a composition to be injected. This allows the cartridge 1, and particularly the injection nozzle 6, to be cleaned between two injections of different compositions. The cleaning solution may be selected from one of the solvents of the composition to be injected in order to be compatible therewith and include isodecane, a volatile silicone or else alcohol or water.

[0222] The cartridge may or may not be refillable.

[0223] As illustrated in FIG. 8, notably but not exclusively when the composition C to be injected into the human keratin materials is liquid, the injection system 150 may comprise a quantity of composition C located within the first chamber 5, between the first piston 9 and a gas buffer 400.

[0224] Preferably, the gas constituting the buffer 400 is ambient air.

[0225] The air buffer 400 may be obtained by means of the first piston 9 rising within the first chamber 5, which causes a quantity of ambient air to be drawn through the opening 6c in the or each outlet channel 6a of the injection nozzle 6, this quantity of ambient air drawn through forming the air buffer 400.

[0226] Preferably, the height of the gas buffer 400 is greater than or equal to half the height of the first piston 5.

[0227] The cartridge may comprise means for heating the composition to be injected or the area of human keratin materials to be treated.

[0228] The cross section and the radius of curvature of the end face 6b of the injection nozzle 6 are chosen, as appropriate, according to the type of keratin materials treated, the face 6b then being applied directly into contact with the keratin materials treated. The radius of curvature may be chosen such as to substantially match the curvature of the treated area. This makes it possible to facilitate the application of the injection system to certain body surfaces. For example, the face 6b has a shape that is outwardly concave.

[0229] A plurality of cartridges 1 having nozzles of different forms may be offered to the user for mounting on the injection device. This makes it possible to select a cartridge 1 that has the injection nozzle that is best suited, in terms of form, to the area of keratin materials to be treated.

[0230] In a variant that has not been illustrated, the cartridge comprises a plurality of first chambers 5 equipped with their respective pistons, such as to allow a plurality of injections in parallel, simultaneously or sequentially. These first chambers may be supplied by one and the same second chamber or by respective second chambers. All the above description relating to an exemplary embodiment comprising only a single first chamber 5 also applies to a variant comprising a plurality of first chambers.

[0231] The injection system 150 may comprise an actuator (not shown), notably of annular form, configured such as to cause the second piston 14 to slide within the second chamber 7 along the longitudinal axis of the injection device 150. This makes it possible to move the reserve of composition contained in the second chamber 7 towards the first chamber 5 so as to refill the latter.

[0232] The gas cartridge 102 may make it possible to drive the actuator. In a variant, the actuator is actuated by an electromagnet or a spring, the compression of which may be manual or motorized, or by any other means.

[0233] In one variant, the cartridge 1 may comprise a plurality of second chambers 7 arranged all around the first chamber 5 and each closed by a second piston at the proximal end thereof. The cartridge 1 may be mounted on the injection device 100 with the ability to rotate. The rotating of the cartridge 1 on the injection device allows the actuator to be aligned with one of the second chambers in a carousel-type arrangement. This rotation may be performed manually or may be motorized. This means the user can select that one of the second chambers 7 from which he or she wishes to supply the first chamber 5.

[0234] In another variant, the device comprises a plurality of actuators.

[0235] The supply to the first chamber 5 from the reserve of composition contained in the second chamber 7 may likewise as appropriate be carried out by means of an element that the user can actuate.

[0236] The injection system 150 may be offered to the user with one or a plurality of cartridges 1 containing one or a plurality of compositions to be injected, for example within common packaging, it being possible for these cartridges each to have a nozzle specific to the type of treatment to be performed.

[0237] The injection system 150 may constitute a portable, autonomous system.

[0238] The injection system 150 may, where appropriate, comprise a system for recognizing the cartridge 1, for example by means of an electromechanical sensor, electrical contacts, or an electronic chip. For example, the cartridge 1 comprises an RFID chip read by the injection device 100. The cartridge 1 may thus be automatically recognized by the injection device 100. The fact that the device is aware that the cartridge is in place may allow operating parameters of the device, for example pressure, duration, flow rate and/or frequency of the pulses of gas leaving the gas cartridge 102, to be adapted automatically.

[0239] In a variant, the operation and/or setting of the injection system 150 is remotely controlled, for example with a smartphone. The injection system 150 then comprises a wireless communication interface.

[0240] The invention is not limited to the examples that have just been described. For example, in one variant, the propulsion mechanism of the injection system has no push rod or first piston for pressurizing the contents of the first chamber.

[0241] For example, the composition is pulverulent and injected from the first chamber by means of a gas jet. In this case, the supply to the first chamber is carried out, for example, by Venturi effect. The speed of the entrainment gas at the outlet of the nozzle is chosen such as to be sufficient to cause the composition to at least partially penetrate the skin.

[0242] The term “comprising” should be understood in its commonly accepted meaning, namely as being synonymous with “comprising at least one”, unless specified to the contrary.