Spirooxindole-copper complex as novel efficient anticorrosion agent for C-steel
11840545 · 2023-12-12
Assignee
Inventors
- Hassan H. Hammud (Al-Ahsa, SA)
- Waleed A. S. Aljamhi (Al-Ahsa, SA)
- Ayman El-Faham (Al-Ahsa, SA)
- Assem Barakat (Al-Ahsa, SA)
- Ihab Shawish (Al-Ahsa, SA)
- Nadeem S. Sheikh (Al-Ahsa, SA)
- Khurshid Ayub (Al-Ahsa, SA)
Cpc classification
International classification
Abstract
New spirooxindole compounds are described herein, as well as the use of such spirooxindole compounds in forming copper complexes that act as efficient anticorrosion agents for C-steel. Also described are methods for forming the new spirooxindole compounds as well as anti-corrosion coatings containing the spirooxindole-copper complexes, CuL.
Claims
1. A compound of the formula I: ##STR00023## wherein X.sub.1, X.sub.2, and X.sub.3 are each independently selected from the group consisting of chlorine, hydrogen, NO.sub.2, and bromine.
2. The compound of claim 1, wherein X.sub.1 and X.sub.3 are both either hydrogen or chlorine.
3. The compound of claim 1, wherein when X.sub.1 and X.sub.3 are both hydrogen, X.sub.2 is bromine or NO.sub.2 and when X.sub.1 and X.sub.3 are both chlorine, X.sub.2 is hydrogen.
4. The compound of claim 1, wherein the compound is selected from the group consisting of: (3R,6'S,7′R)-6-chloro-7′-(2,4-dichlorophenyl)-6′-(5-methyl-1H-1,2,3-triazole-4-carbonyl)-1′,6′,7′,7a′-tetrahydro-3′H-spiro[indoline-3,5′-pyrrolo[1,2-c]thiazol]-2-one (SP34); (3R,6'S,7′R)-6-chloro-6′-(5-methyl-1H-1,2,3-triazole-4-carbonyl)-7′-(3-nitrophenyl)-1′,6′,7′,7a′-tetrahydro-3′H-spiro[indoline-3,5′-pyrrolo[1,2-c]thiazol]-2-one (SP37); and (3R,6'S,7′R)-7′-(3-bromophenyl)-6-chloro-6′-(5-methyl-1H-1,2,3-triazole-4-carbonyl)-1′,6′,7′,7a′-tetrahydro-3′H-spiro[indoline-3,5′-pyrrolo[1,2-c]thiazol]-2-one (SP311).
5. A copper complex comprising a complex of the formula II:
CuL II wherein L is a ligand that is the compound of claim 1.
6. A method for making the copper complex of claim 5, the method comprising: reacting equimolar amounts of the compound of claim 1 and copper chloride (CuCl) in an organic solvent; and obtaining the copper complex.
7. An anticorrosion coating comprising the copper complex of claim 5.
8. A method of preventing corrosion in a material, comprising: administering a continuous monolayer of the anticorrosion coating of claim 7 to a material selected from the group consisting of steel, iron, copper, and a combination thereof.
9. The method of claim 8, wherein the material is formed as a homogeneous flat solid surface.
10. The method of claim 8, wherein the material is formed as an electrical wire, a pipe, or piping.
11. A method of preparing the compound of claim 1, the method comprising: adding about one equivalent of (s)-Thiazolidine-4-carboxylic acid to a solution of about one equivalent of a compound of formula III in an organic solvent to obtain a first mixture: ##STR00024## wherein R.sub.1 is selected from the group consisting of hydrogen, chlorine, fluorine, bromine, and NO.sub.2 and R.sub.2 is selected from the group consisting of hydrogen and chlorine; adding a chalcone of formula IV to the first mixture and refluxing for about 6 to about 12 hours to obtain a second mixture: ##STR00025## wherein X.sub.1, X.sub.2, and X.sub.3 are each independently selected from the group consisting of chlorine, hydrogen, NO.sub.2, and bromine; evaporating the organic solvent from the second mixture to obtain a crude product; and purifying the crude product by column chromatography to obtain the compound of claim 1.
12. The method of claim 11, wherein the organic solvent is methanol.
13. The method of claim 11, wherein a yield of the compound of claim 1 is about 65% to about 90%.
14. A method of preparing the compound of claim 1, the method comprising: adding about one equivalent of 1-(1-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-5-methyl-1H-1,2,3-triazol-4-yl) (B) to ethanol until dissolved; adding an about 7% KOH dropwise with stirring for about 5 minutes to obtain a reaction mixture; placing the reaction mixture in an ice bath and adding a benzaldehyde of formula V with stirring for about 1 to about 2 hours: ##STR00026## wherein X.sub.1, X.sub.2, and X.sub.3 are each independently selected from the group consisting of chlorine, hydrogen, NO.sub.2, and bromine; evaporating the ethanol and extracting a chalcone of formula IV: ##STR00027## adding one equivalent of (s)-Thiazolidine-4-carboxylic acid to a solution of one equivalent of a compound of formula III in an organic solvent to obtain a first mixture: ##STR00028## wherein R.sub.1 is selected from the group consisting of hydrogen, chlorine, fluorine, bromine, and NO.sub.2 and R.sub.2 is selected from the group consisting of hydrogen and chlorine; adding the chalcone of formula IV to the first mixture and refluxing for about 6 to about 12 hours to obtain a second mixture; evaporating the organic solvent from the second mixture to obtain a crude product; and purifying the crude product by column chromatography to obtain the compound of claim 1.
15. A method of preparing the compound of claim 1, the method comprising: adding methanol to cyanuric chloride followed by NaHCO.sub.3 with stirring at about 0° C., followed by stirring at room temperature for about 30 minutes, extraction, and drying to obtain 2,4-dichloro-6-methoxy-1,3,5-triazine; dissolving the 2,4-dichloro-6-methoxy-1,3,5-triazine in MeCn followed by adding a solution of sodium azide in water and stirring, first in an ice bath then at room temperature, extraction, concentration, and drying to obtain 2-Azido-4,6-dimethoxy-1,3,5-triazine (A); adding about one equivalent of the 2-Azido-4,6-dimethoxy-1,3,5-triazine (A) to a stirred solution of about 1.2 equivalents of acetylacetone and about 1.2 equivalents of TEA in DMF followed by adding water, filtering, and drying to obtain 1-(1-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-5-methyl-1H-1,2,3-triazol-4-yl) (B); adding about one equivalent of the 1-(1-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-5-methyl-1H-1,2,3-triazol-4-yl) (B) to ethanol until dissolved; adding an about 7% KOH dropwise with stirring for about 5 minutes to obtain a reaction mixture; placing the reaction mixture in an ice bath and adding a benzaldehyde of formula V with stirring for about 1 to about 2 hours: ##STR00029## wherein X.sub.1, X.sub.2, and X.sub.3 are each independently selected from the group consisting of chlorine, hydrogen, NO.sub.2, and bromine; evaporating the ethanol and extracting a chalcone of formula IV: ##STR00030## adding one equivalent of (s)-Thiazolidine-4-carboxylic acid to a solution of one equivalent of a compound of formula III in an organic solvent to obtain a first mixture: ##STR00031## wherein R.sub.1 is selected from the group consisting of hydrogen, chlorine, fluorine, bromine, and NO.sub.2 and R.sub.2 is selected from the group consisting of hydrogen and chlorine; adding the chalcone of formula IV to the first mixture and refluxing for about 6 to about 12 hours to obtain a second mixture; evaporating the organic solvent from the second mixture to obtain a crude product; and purifying the crude product by column chromatography to obtain the compound of claim 1.
16. The method of claim 15, wherein a yield of the compound of claim 1 is about 65% to about 90%.
Description
BRIEF DESCRIPTION OF DRAWINGS
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(29) Similar reference characters denote corresponding features consistently throughout the attached drawings.
DETAILED DESCRIPTION
(30) The following definitions are provided for the purpose of understanding the present subject matter and for construing the appended patent claims.
(31) Throughout the application, where compositions are described as having, including, or comprising specific components, or where processes are described as having, including, or comprising specific process steps, it is contemplated that compositions of the present teachings can also consist essentially of, or consist of, the recited components, and that the processes of the present teachings can also consist essentially of, or consist of, the recited process steps.
(32) It is noted that, as used in this specification and the appended claims, the singular forms “a”, “an”, and “the” include plural references unless the context clearly dictates otherwise.
(33) In the application, where an element or component is said to be included in and/or selected from a list of recited elements or components, it should be understood that the element or component can be any one of the recited elements or components, or the element or component can be selected from a group consisting of two or more of the recited elements or components. Further, it should be understood that elements and/or features of a composition or a method described herein can be combined in a variety of ways without departing from the spirit and scope of the present teachings, whether explicit or implicit herein.
(34) The use of the terms “include,” “includes”, “including,” “have,” “has,” or “having” should be generally understood as open-ended and non-limiting unless specifically stated otherwise.
(35) The use of the singular herein includes the plural (and vice versa) unless specifically stated otherwise. In addition, where the use of the term “about” is before a quantitative value, the present teachings also include the specific quantitative value itself, unless specifically stated otherwise. As used herein, the term “about” refers to a ±10% variation from the nominal value unless otherwise indicated or inferred.
(36) The term “optional” or “optionally” means that the subsequently described event or circumstance may or may not occur, and that the description includes instances where said event or circumstance occurs and instances in which it does not.
(37) Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood to one of ordinary skill in the art to which the presently described subject matter pertains.
(38) Where a range of values is provided, for example, concentration ranges, percentage ranges, or ratio ranges, it is understood that each intervening value, to the tenth of the unit of the lower limit, unless the context clearly dictates otherwise, between the upper and lower limit of that range and any other stated or intervening value in that stated range, is encompassed within the described subject matter. The upper and lower limits of these smaller ranges may independently be included in the smaller ranges, and such embodiments are also encompassed within the described subject matter, subject to any specifically excluded limit in the stated range. Where the stated range includes one or both of the limits, ranges excluding either or both of those included limits are also included in the described subject matter.
(39) Throughout the application, descriptions of various embodiments use “comprising” language. However, it will be understood by one of skill in the art, that in some specific instances, an embodiment can alternatively be described using the language “consisting essentially of” or “consisting of”.
(40) For purposes of better understanding the present teachings and in no way limiting the scope of the teachings, unless otherwise indicated, all numbers expressing quantities, percentages or proportions, and other numerical values used in the specification and claims, are to be understood as being modified in all instances by the term “about”. Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and attached claims are approximations that may vary depending upon the desired properties sought to be obtained. At the very least, each numerical parameter should at least be construed in light of the number of reported significant digits and by applying ordinary rounding techniques.
(41) The present subject matter relates to new nitrophenyl spirooxindole derivatives that can be used as a ligand L to prepare a copper complex. The complex CuL can have much higher anticorrosion inhibitory effects than its ligand for C-steel, for example, in 1 M HCl solution.
(42) Accordingly, in one embodiment, the present subject matter relates to a compound of the formula I:
(43) ##STR00010##
wherein X.sub.1, X.sub.2, and X.sub.3 are each independently selected from the group consisting of chlorine, hydrogen, NO.sub.2, and bromine.
(44) In an embodiment, the present subject matter relates to a compound of formula I, wherein X.sub.1 and X.sub.3 are both either hydrogen or chlorine. In another embodiment, when X.sub.1 and X.sub.3 are both hydrogen, X.sub.2 is bromine or NO.sub.2 and when X.sub.1 and X.sub.3 are both chlorine, X.sub.2 is hydrogen.
(45) In a further embodiment, the compound of formula I can be selected from the group consisting of: (3R,6'S,7′R)-6-chloro-7′-(2,4-dichlorophenyl)-6′-(5-methyl-1H-1,2,3-triazole-4-carbonyl)-1′,6′,7′,7a′-tetrahydro-3′H-spiro[indoline-3,5′-pyrrolo[1,2-c]thiazol]-2-one (SP34); (3R,6'S,7′R)-6-chloro-6′-(5-methyl-1H-1,2,3-triazole-4-carbonyl)-7′-(3-nitrophenyl)-1′,6′,7′,7a′-tetrahydro-3′H-spiro[indoline-3,5′-pyrrolo[1,2-c]thiazol]-2-one (SP37); and (3R,6'S,7′R)-7′-(3-bromophenyl)-6-chloro-6′-(5-methyl-1H-1,2,3-triazole-4-carbonyl)-1′,6′,7′,7a′-tetrahydro-3′H-spiro[indoline-3,5′-pyrrolo[1,2-c]thiazol]-2-one (SP311).
(46) Stated differently, the compound of formula I can be selected from the group consisting of:
(47) ##STR00011##
(48) In another embodiment, the present subject matter relates to a copper complex comprising a complex of the formula II:
CuL II
wherein L is a ligand that is the compounds as described herein.
(49) In an embodiment, the present copper complex can have an inhibition of anticorrosion of 97% or greater.
(50) In a further embodiment, the present subject matter relates to a method for making the copper complex as described herein, the method comprising: reacting equimolar amounts (e.g., 1:1 on a molar basis) of the compound of formula I and copper chloride (CuCl) in an organic solvent; and obtaining the copper complex.
(51) In an embodiment, the thus formed CuL copper complex can undergo anticorrosion studies by adding the obtained CuL copper complex to hydrochloric acid (for example, at 1M) using a C-steel electrode.
(52) In another embodiment, the CuL copper complexes, where the ligand L is one of the spiro compounds SP34, SP37, or SP311, showed better inhibition of anticorrosion than the ligand L itself based on impedance and polarization studies that reached (99.2%) for the Cu-SP34 complex; (98.9%) for the Cu-SP37 complex and (97.9%) for the Cu-SP311 complex. Accordingly, in an embodiment, the CuL complex can provide a better, more rigid coat than the corresponding ligands. In general, the % inhibition of spirooxindole complexes and compounds follow the trends SP34>SP37>SP311.
(53) In an embodiment, the present subject matter relates to an anticorrosion coating comprising the copper complex as described herein.
(54) In a further embodiment in this regard, the anticorrosion coating, when applied to a material, can inhibit corrosion of the material, wherein the material is selected from the group consisting of steel, iron, copper, and a combination thereof. Thus, the present copper complex can provide an anticorrosion coat for steel, iron, and copper accessories, hardware, equipment, and construction materials. Further, the present anticorrosion coating can also optionally include other related organo-metallic inhibitors, or any other additives and fillers that can assist in providing coating uniformity, improve coating flow or surface drying, and/or decrease the permeability of water and/or oxygen. Further, when applied to the material, the anticorrosion coating can have a lifetime of more than 10 years. In addition, in use, a continuous monolayer of the anticorrosion coating can cover a homogeneous flat solid surface.
(55) In one more embodiment, the present subject matter relates to a method of preventing corrosion in a material, comprising: administering a continuous monolayer of the anticorrosion coating as described herein to a material selected from the group consisting of steel, iron, copper, and a combination thereof.
(56) In another embodiment in this regard, the material can be formed as a homogeneous flat solid surface. In a further embodiment, the material can be formed as an electrical wire, a pipe, pipeline, or piping. Suitable industries for which these materials may be of suitable interest include the oil and gas, chemical, petrochemical, infrastructure, marine, power generation, and medicinal chemistry industries.
(57) Generally stated, the present compounds can be formed according to the following synthetic methodology for preparing the present spirooxindole derivatives:
(58) ##STR00012## ##STR00013## ##STR00014##
(59) In a further embodiment, the present subject matter relates to a method of preparing the compound of formula I, the method comprising: adding about one equivalent of (s)-Thiazolidine-4-carboxylic acid to a solution of about one equivalent of a compound of formula III in an organic solvent to obtain a first mixture:
(60) ##STR00015##
wherein R.sub.1 is selected from the group consisting of hydrogen, chlorine, fluorine, bromine, and NO.sub.2 and R.sub.2 is selected from the group consisting of hydrogen and chlorine; adding a chalcone of formula IV to the first mixture and refluxing for about 6 to about 12 hours to obtain a second mixture:
(61) ##STR00016##
wherein X.sub.1, X.sub.2, and X.sub.3 are each independently selected from the group consisting of chlorine, hydrogen, NO.sub.2, and bromine; evaporating the organic solvent from the second mixture to obtain a crude product; and purifying the crude product by column chromatography to obtain the compound of formula I.
(62) In an embodiment, the present subject matter relates to a method of preparing the compound of formula I, the method comprising: adding about one equivalent of 1-(1-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-5-methyl-1H-1,2,3-triazol-4-yl) (B) to ethanol until dissolved; adding an about 7% KOH dropwise with stirring for about 5 minutes to obtain a reaction mixture; placing the reaction mixture in an ice bath and adding a benzaldehyde of formula V with stirring for about 1 to about 2 hours:
(63) ##STR00017##
wherein X.sub.1, X.sub.2, and X.sub.3 are each independently selected from the group consisting of chlorine, hydrogen, NO.sub.2, and bromine;
evaporating the ethanol and extracting a chalcone of formula IV:
(64) ##STR00018##
adding one equivalent of (s)-Thiazolidine-4-carboxylic acid to a solution of one equivalent of a compound of formula III in an organic solvent to obtain a first mixture:
(65) ##STR00019##
wherein R.sub.1 is selected from the group consisting of hydrogen, chlorine, fluorine, bromine, and NO.sub.2 and R.sub.2 is selected from the group consisting of hydrogen and chlorine; adding the chalcone of formula IV to the first mixture and refluxing for about 6 to about 12 hours to obtain a second mixture; evaporating the organic solvent from the second mixture to obtain a crude product; and purifying the crude product by column chromatography to obtain the compound of formula I.
(66) In one more embodiment, the present subject matter relates to a method of preparing the compound of formula I, the method comprising: adding methanol to cyanuric chloride followed by NaHCO.sub.3 with stirring at about 0° C., followed by stirring at room temperature for about 30 minutes, extraction, and drying to obtain 2,4-dichloro-6-methoxy-1,3,5-triazine; dissolving the 2,4-dichloro-6-methoxy-1,3,5-triazine in MeCn followed by adding a solution of sodium azide in water and stirring, first in an ice bath then at room temperature, extraction, concentration, and drying to obtain 2-Azido-4,6-dimethoxy-1,3,5-triazine (A); adding about one equivalent of the 2-Azido-4,6-dimethoxy-1,3,5-triazine (A) to a stirred solution of about 1.2 equivalents of acetylacetone and about 1.2 equivalents of TEA in DMF followed by adding water, filtering, and drying to obtain 1-(1-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-5-methyl-1H-1,2,3-triazol-4-yl) (B); adding about one equivalent of the 1-(1-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-5-methyl-1H-1,2,3-triazol-4-yl) (B) to ethanol until dissolved; adding an about 7% KOH dropwise with stirring for about 5 minutes to obtain a reaction mixture; placing the reaction mixture in an ice bath and adding a benzaldehyde of formula V with stirring for about 1 to about 2 hours:
(67) ##STR00020##
wherein X.sub.1, X.sub.2, and X.sub.3 are each independently selected from the group consisting of chlorine, hydrogen, NO.sub.2, and bromine, evaporating the ethanol and extracting a chalcone of formula IV:
(68) ##STR00021##
adding one equivalent of (s)-Thiazolidine-4-carboxylic acid to a solution of one equivalent of a compound of formula III in an organic solvent to obtain a first mixture:
(69) ##STR00022##
wherein R.sub.1 is selected from the group consisting of hydrogen, chlorine, fluorine, bromine, and NO.sub.2 and R.sub.2 is selected from the group consisting of hydrogen and chlorine; adding the chalcone of formula IV to the first mixture and refluxing for about 6 to about 12 hours to obtain a second mixture; evaporating the organic solvent from the second mixture to obtain a crude product; and purifying the crude product by column chromatography to obtain the compound of formula I.
(70) In any of these production methods, in the step for obtaining the compound of formula I, the organic solvent can be, by way of non-limiting example, methanol or another suitable alcohol. Further, these production methods can each provide a yield of the compound of formula I of about 65% to about 90%.
Examples
Synthetic Examples
Example 1: General Procedure for the Synthesis of 1-(1-(4,6-dimethoxy-1,3,5-triazin-2-yl)-5-methyl-1H-1,2,3-triazol-4-yl)ethan-1-one, Formula V
(71) 150 mL of methanol was added to cyanuric chloride (16.59 g, 90 mmol) followed by NaHCO.sub.3 (15.12 g, 180 mmol) portion wise with stirring at 0° C. The reaction mixture was further stirred at room temperature for 30 min (until the gas bubbles completely disappeared). Subsequently, excess water was added, and the reaction mixture was extracted with DCM (3×50 mL) and dried over (Na.sub.2SO.sub.4), after the solvent was evaporated under vacuum to get 2-chloro-4,6-dimethoxy-1,3,5-triazine as a white solid (98%): mp 86-87° C. Subsequently, 2-chloro-4,6-dimethoxy-1,3,5-triazine (2.5 g, 14 mmol) was dissolved in MeCN (100 mL) and stirred in an ice-water bath for 10 minutes. Then a solution of sodium azide (1.0 g, 15.4 mmol) in 5 mL of H.sub.2O was added and the reaction mixture was stirred in the ice bath for 30 minutes and continued stirring at room temperature for a further 4 h. After the reaction was complete as indicated by TLC (Ethyl acetate: hexane, 1:1), the solvent was removed under vacuum at room temperature (without heating) until the volume was reduced to a quarter of its original volume. The residue was poured into water, which was extracted with DCM (3×50 mL). The combined organic phase was washed with brine (50 mL), dried over Na.sub.2SO.sub.4 and concentrated in vacuum to provide the pure product of 2-Azido-4,6-dimethoxy-1,3,5-triazine (A) which was employed in the next synthetic step without further purification.
(72) 2,4-Dimethoxy triazolyl-s-triazene (Formula V)) was synthesized by adding the corresponding azido-triazine derivative (Formula IV) (1 equivalent) to a stirred solution of acetylacetone (1.2 equivalent) and TEA (1.2 equivalent) in DMF. The progress of the reaction was monitored by TLC (CHCl.sub.3/MeOH, 9:1) which showed the completion of the reaction after 2-3 hours. Excess water was then added to afford the product (B) as an off-white solid which was filtered, washed with n-hexane and dried. The yield of this reaction was 85-90% and the products were collected in their pure formulas and used directly in the next step.
1-(1-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-5-methyl-1H-1,2,3-triazol-4-yl) ethan-1-one, Formula V)
(73) The target compound of 1-(1-(4,6-dimethoxy-1,3,5-triazin-2-yl)-5-methyl-1H-1,2,3-triazol-4-yl)ethan-1-one (Formula V)) was collected as a pale-yellow solid in 90% yield; m.p. 201-203° C.; .sup.1H NMR (500 MHz, CDCl.sub.3) δ 4.13 (t, J=1.7 Hz, 6H, 2CH.sub.3O), 3.00-2.96 (m, 3H), 2.75-2.71 (m, 3H, CH.sub.3C═O); .sup.13C NMR (126 MHz, CDCl.sub.3) δ 194.40 (C═O), 173.49, 164.65 (C-Triazine), 144.14, 139.93 (2C-Triazole), 56.32 (2CH3O), 28.55 (CH.sub.3C═O), 11.99 (CH.sub.3-triazole); Anal. Calc. for C.sub.10H.sub.12N.sub.6O.sub.3 (264.25); C, 45.45; H, 4.58; N, 31.80. Found C, 45.33; H, 4.49; N, 31.75; HRMS-ESI (m/z) calculated for [M+H]+ 265.25; found: 265.3901.
Example 2: General Procedure for the Synthesis of Chalcones (d1-3) (GP 1)
(74) 1-(1-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-5-methyl-1H-1,2,3-triazol-4-yl) (Formula V)) (1 equivalent) was added to ethanol with gentle warming until the entire amount dissolved, then 7% (w/v) KOH solution was added dropwise, and the mixture was stirred at room temperature for 5 minutes. Subsequently, the reaction mixture was placed into an ice bath and substituted benzaldehyde derivative was added portion wise while stirring for 1-2 h. The progress of the reaction was monitored by TLC (ethyl acetate/n-hexane 4:6) which showed the formation of the desired chalcones mixed with traces of side products. After the reaction was complete, the organic solvent was evaporated under vacuum and the desired product was extracted from the aqueous layer by ethyl acetate (3×15 mL). The aqueous layer was then acidified by 10% (v/v) HCl and the residual chalcone was extracted by DCM (3×15 mL). The organic solvents were dried over magnesium sulphate and evaporated under reduced pressure. The impure oily product was then purified by column chromatography (ethyl acetate-petroleum ether 3:7) to afford the target chalcones Formula VII (d1-3) as a pale-yellow solid in a good yield (60-75%).
(E)-3-(2,4-Dichlorophenyl)-1-(5-methyl-1H-1,2,3-triazol-4-yl)prop-2-en-1-one, d1
(75) According to the general procedure (GP 1); 1-(1-(4,6-dimethoxy-1,3,5-triazin-2-yl)-5-methyl-1H-1,2,3-triazol-4-yl) ethan-1-one (Formula V) and 2,4-dichloro benzaldehyde were reacted to afford chalcone (d1) as an off-white solid in 73% yield; m.p. 220-22° C.; .sup.1H NMR (400 MHz, DMSO-d.sub.6) δ 7.99 (d, J 16.0 Hz, 1H), 7.95 (m, 2H), 7.66 (dt, J=14.2, 6.7 Hz, 1H), 7.44 (d, J=16.6 Hz, 1H) (3 Aromatic Protons and H-C5, H-C6), 2.34-2.47 (m, J=4.3 Hz, 3H, 3H-C1), .sup.13C NMR (101 MHz, DMSO-d.sub.6) δ 183.66 (C═O), 141.67, 139.24, 137.81, 136.64, 136.11, 135.63, 130.96, 129.52, 128.62, 123.79 (6 Aromatic C+C2,3,5,6), 28.00 (C1); Anal. Calc. for C.sub.12H.sub.9C.sub.12N.sub.3O (282.12); C, 51.09; H, 3.22; N, 14.89. Found C, 51.00; H, 3.31; N, 14.93; HRMS-ESI (m/z) calculated for [M+H]+ 283.12; found: 283.0895.
(E)-1-(5-Methyl-1H-1,2,3-triazol-4-yl)-3-(3-nitrophenyl) prop-2-en-1-one, d2
(76) According to the general procedure (GP 1); 1-(1-(4,6-dimethoxy-1,3,5-triazin-2-yl)-5-methyl-1H-1,2,3-triazol-4-yl) ethan-1-one (Formula V) and 3-nitrobenzaldehyde were reacted to afford chalcone (d2) as a pale-yellow solid in 68% yield; m.p. 207-210° C.; .sup.1H NMR (400 MHz, DMSO-d6) δ 12.51 (s, 1H, NH), 8.57 (s, 1H), 8.26 (d, J=8.7 Hz, 2H), 8.14-7.97 (m, 1H), 7.97-7.79 (m, 1H), 7.61 (dt, J=14.8, 8.4 Hz, 1H) (4 Aromatic Protons and H-C5, H—C-6), 2.43 (d, J=3.6 Hz, 3H, 3H-C1); .sup.13C NMR (101 MHz, DMSO-d6) δ 184.17 (C═O), 149.74, 148.70 (d, J=43.3 Hz), 143.97, 140.93, 136.00, 133.79, 131.12, 126.14, 125.64, 124.13 (6 Aromatic C+C2,3,5,6), 26.95 (C1); Anal. Calc. for C.sub.12H.sub.10N.sub.4O.sub.3 (258.24); C, 55.81; H, 3.90; N, 21.70. Found C, 55.94; H, 3.79; N, 21.81; HRMS-ESI (m/z) calculated for [M+H]+ 259.24; found: 259.3074.
(E)-3-(3-Bromophenyl)-1-(5-methyl-1H-1,2,3-triazol-4-yl) prop-2-en-1-one, d3
(77) According to the general procedure (GP 4.1); 1-(1-(4,6-dimethoxy-1,3,5-triazin-2-yl)-5-methyl-1H-1,2,3-triazol-4-yl) ethan-1-one (Formula V) and 3-bromobenzaldehyde were reacted to afford chalcone (d3) as a pale-yellow precipitate with 65% chemical yield, m.p. 193-195° C.; .sup.1H NMR (500 MHz, DMSO-d6) δ 7.98 (q, J=1.8 Hz, 1H), 7.91-7.81 (m, 1H), 7.81-7.73 (m, 1H), 7.71-7.65 (m, 1H), 7.65-7.57 (m, 1H), 7.47-7.32 (m, 1H) (4 Aromatic Protons and H-C5, H—C-6), 2.40 (s, 3H, 3H-C1), .sup.13C NMR (126 MHz, DMSO-d6) δ 183.87 (C═O), 141.51, 137.49, 136.12, 133.65, 131.70, 131.63, 131.44, 127.92, 125.02, 122.92 (6 Aromatic Carbons+C2,3,5,6), 28.07 (C1); Anal. Calc. for C.sub.12H.sub.10BrN.sub.3O (292.14); C, 49.34; H, 3.45; N, 14.38. Found C, 49.21; H, 3.49; N, 14.50; HRMS-ESI (m/z) calculated for [M+H]+ 293.14; found: 293.2674.
Example 3: General Procedure for the Synthesis of Spirooxindole Derivatives (SP34, SP37, and SP311) (GP 4.2)
(78) (s)-Thiazolidine-4-carboxylic acid (1 equivalent) was added to a solution of 6-chloroisatin (1 equivalent) in methanol and the mixture was stirred at room temperature for 15 minutes. Thereafter, chalcone (d1-3) was added and the reaction was refluxed in an oil bath for about 6-12 hours. Once the reaction was complete as indicated by TLC analysis (ethyl acetate/n-hexane 6:4); the solvent was evaporated under reduced pressure and the crude product was purified by column chromatography (ethyl acetate-petroleum ether 4:6) to afford the spiro derivative (SP34, SP37, and SP3111) as an off-white solid with a yield of (75-90%). In some cases, the product had oily texture after evaporating the solvent which required dissolving in diethyl ether followed by the addition of a small amount of n-hexane to afford the spiro product as an off-white precipitate which was subsequently collected by removing the solvent under vacuum.
(3R,6′S,7′R)-6-chloro-7′-(2,4-dichlorophenyl)-6′-(5-methyl-1H-1,2,3-triazole-4-carbonyl)-1′,6′,7′,7a′-tetrahydro-3′H-spiro[indoline-3,5′-pyrrolo[1,2-c]thiazol]-2-one, SP34
(79) The reaction of 6-chloroisatin with (S)-thiazolidine-4-carboxylic acid followed by chalcone (d1) was carried out according to the general procedure (GP 4.2). The target spiro derivative (SP34) was collected as an off-white solid in 88% yield; m.p. 199-201° C.; .sup.1H NMR (400 MHz, DMSO-d.sub.6) δ 15.29 (s, 1H, NH), 10.60 (s, 1H, NHC═O), 7.81 (q, J=11.5, 10.7 Hz, 1H), 7.61 (s, 1H), 7.50 (d, J=8.4 Hz, 1H), 7.10 (d, J=8.4 Hz, 1H), 6.94 (d, J=7.3 Hz, 1H), 6.55 (s, 1H) (6 aromatic protons), 4.91 (d, J=9.5 Hz, 1H, H-C5), 4.52 (t, J=8.9 Hz, 1H, H-C2), 4.06 (q, J=5.9 Hz, 1H, H-C1), 3.71 (s, 1H), 3.41 (s, 1H, H-C4), 3.09 (d, J=6.6 Hz, 1H, H-C4), 2.99-2.82 (m, 1H, H-C3), 2.05 (d, J=31.7 Hz, 3H, H—C6); .sup.13C NMR (126 MHz, DMSO-d6) δ 191.07 (C═O), 178.88 (—NHC═O), 144.57, 137.22, 134.91, 134.59, 132.82, 130.94, 129.44, 128.90, 128.52, 122.63, 121.06, 109.95 (Aromatic Carbons), 75.07 (Shared C), 72.70 (C2), 63.94 (C4), 53.03 (C5), 44.23 (C3), 35.64 (C1), 14.48 (d, J=14.6 Hz, C6); Anal. Calc. for C.sub.23H.sub.18C.sub.13N.sub.5O.sub.2S (534.84); C, 51.65; H, 3.39; N, 13.09. Found C, 51.59; H, 3.29; N, 13.11; HRMS-ESI (m/z) calculated for [M+H]+ 535.84; found: 535.8009.
(3R,6'S,7′R)-6-chloro-6′-(5-methyl-1H-1,2,3-triazole-4-carbonyl)-7′-(3-nitrophenyl)-1′,6′,7′,7a′-tetrahydro-3′H-spiro[indoline-3,5′-pyrrolo[1,2-c]thiazol]-2-one, SP37
(80) The implementation of the general procedure (GP 4.2) by involving (S)-thiazolidine-4-carboxylic acid, chalcone (d3), and 6-chloroisatin led up to the formation of the target spiro derivative (SP37) which was collected as a pale-yellow solid in 75% yield; m.p. 179-181° C.; 1H NMR (400 MHz, DMSO-d.sub.6) δ 15.29 (s, 1H, NH), 10.55 (s, 1H, NHC═O), 8.32 (d, J=7.5 Hz, 1H), 8.13 (d, J=8.9 Hz, 1H), 8.10-7.97 (m, 1H), 7.66 (dt, J 14.0, 7.7 Hz, 1H), 7.30-7.10 (m, 1H), 6.92 (d, J=9.5 Hz, 1H), 6.56 (s, 1H) (7 Aromatic H), 4.88 (d, J=10.6 Hz, 1H, H-C5), 4.25-4.16 (m, 1H, H-C2), 4.11 (t, J=9.8 Hz, 1H, H—C1), 3.67 (d, J=9.0 Hz, 1H, H-C4), 3.48-3.40 (m, 1H, H-C4), 2.99 (tt, J=14.8, 7.2 Hz, 2H, H-C3), 2.11-1.86 (m, 3H, H-C6); 13C NMR (126 MHz, DMSO-d6) δ 191.08 (C═O), 178.24 (—NHC═O), 148.55, 145.83, 143.61, 142.40, 140.33, 135.48, 133.95, 130.92, 128.8, 123.37, 122.79, 121.05, 109.81 (Aromatic C), 74.35 (Shared C), 71.62 (C2), 65.13 (C4), 51.61 (C5), 48.50 (C3), 35.12 (C1), 20.24 (C6); Anal. Calc. for C.sub.23H.sub.19ClN.sub.6O.sub.4S (510.95); C, 54.07; H, 3.75; N, 16.45. Found C, 54.03; H, 3.91; N, 16.50; HRMS-ESI (m/z) calculated for [M+H]+ 511.95; found: 512.1020.
(3R,6'S,7′R)-7′-(3-bromophenyl)-6-chloro-6′-(5-methyl-1H-1,2,3-triazole-4-carbonyl)-1′,6′,7′,7a′-tetrahydro-3′H-spiro[indoline-3,5′-pyrrolo[1,2-c]thiazol]-2-one, SP311
(81) The spiro derivative (SP311) was prepared according to the general procedure (GP 4.2) by involving chalcone (d3), 6-chloroisatin, and (S)-thiazolidine-4-carboxylic acid in the same synthetic pathway to afford the target product as an off-white solid in 73% yield; m.p. 178-182° C.; .sup.1H NMR (400 MHz, DMSO-d.sub.6) δ 15.26 (s, 1H, NH), 10.78-10.37 (m, 1H, NHC═O), 7.66 (s, 1H), 7.54-7.43 (m, 2H), 7.38-7.20 (m, 2H), 7.02-6.84 (m, 1H), 6.55 (q, J=9.8, 7.7 Hz, 1H) (7 Aromatic H), 5.16-4.70 (m, 1H, H-C5), 4.34-4.20 (m, 1H, H-C2), 3.89 (t, J=10.0 Hz, 1H, H-C1), 3.65 (d, J=9.2 Hz, 1H, H-C4), 3.55 (s, 1H, H-C4), 3.18-2.77 (m, 2H, 2H-C3), 2.08 (q, J=12.4, 11.0 Hz, 3H, 2H-C6), .sup.13C NMR (101 MHz, DMSO-d6) δ 189.14 (C═O), 178.82 (—NHC═O), 144.76, 142.03, 138.38, 134.97, 132.73, 131.52, 130.23, 129.71, 129.15, 124.39, 122.26, 109.96 (Aromatic C), 74.88 (Shared C), 72.74 (C2), 63.59 (C4), 52.85 (C5), 43.51 (C3), 35.24 (C1), 14.87 (C6); Anal. Calc. for C.sub.23H.sub.19BrClN.sub.5O.sub.2S (544.85); C, 50.70; H, 3.52; N, 12.85. Found C, 50.80; H, 3.44; N, 12.91; HRMS-ESI (m/z) calculated for [M+H]+ 545.85; found: 545.995.
Electrochemical Anticorrosion Studies
(82) The % inhibition of Spiro compounds SP34, SP37 and SP311 and their copper complexes for C-steel in hydrochloric acid solution (1M) were computed by Impedance and Polarization studies. The model used for the electrochemical equivalent circuit to fit the impedance for anticorrosion studies of Carbon steel (C-steel) by Spiro inhibitors was CPE with diffusion as shown in
Example 4: Spiro-NO.SUB.2 .Derivative (SP 37) (L and CuL)
(83)
(84) The accompanying data can be found in Tables 1-4, below.
(85) TABLE-US-00001 TABLE 1 Impedance parameters for Spiro-NO.sub.2 (SP 37) on the C-steel in 1M HCl medium by fitting the equivalent circuit model CPE with Diffusion. SP 37 Model CPE Z.sub.CPE with Ru Ru Rp Rp Z.sub.CPE Ω.sup.−1s.sup.n Cdl Cdl IE W Diffusion Ω Ω cm.sup.2 Ω Ω cm.sup.2 n Ω.sup.−1s.sup.n cm.sup.−2 F μF/cm.sup.2 θ % Ss.sup.1/2 0 2.09 1.05 24.13 12.13 0.855 3.27 × 6.50 × 1.44 × 2.86 × 0.000 0.00 6.05 × mM 10.sup.4 10.sup.2 10.sup.−4 10.sup.2 10.sup.−1 0.039 2.27 1.14 30.64 15.40 0.873 2.30 × 4.57 × 1.12 × 2.23 × 0.212 21.25 1.11 × mM 10.sup.−4 10.sup.2 10.sup.−4 10.sup.2 10.sup.0 0.078 4.40 2.21 45.4 22.82 0.871 1.67 × 3.33 × 8.14 × 1.62 × 0.469 46.85 1.45 × mM 10.sup.−4 10.sup.2 10.sup.−5 10.sup.2 10.sup.0 0.117 2.66 1.34 55.51 27.90 0.860 1.59 × 3.16 × 7.35 × 1.46 × 0.565 56.53 3.80 × mM 10.sup.−4 10.sup.2 10.sup.−5 10.sup.2 10.sup.0
(86) TABLE-US-00002 TABLE 2 Impedance parameters for Spiro-NO.sub.2 complex (CuL where L = SP 37) on the C- steel in 1M HCl medium by fitting the equivalent circuit model CPE with Diffusion. CuL Model CPE Z.sub.CPE with Ru Ru Rp Rp Z.sub.CPE Ω.sup.−1s.sup.n Cdl Cdl IE W Diffusion Ω Ω cm.sup.2 Ω Ω cm.sup.2 n Ω.sup.−1s.sup.n cm.sup.−2 F μF/cm.sup.2 θ % Ss.sup.1/2 0 mM 2.09 1.05 24.13 12.13 0.855 3.27 × 6.50 × 1.44 × 2.86 × 0.000 0.00 6.05 × 10.sup.−4 10.sup.2 10.sup.−4 10.sup.2 10.sup.−1 0.039 2.22 1.11 346.8 174.34 0.847 7.84 × 1.56 × 4.08 × 8.12 × 0.930 93.04 4.40 × mM 10.sup.−5 10.sup.2 10.sup.−5 10.sup.1 10.sup.−2 0.078 2.12 1.07 531.3 267.08 0.838 7.44 × 1.48 × 3.98 × 7.91 × 0.955 95.46 2.67 × mM 10.sup.−5 10.sup.2 10.sup.−5 10.sup.1 10.sup.−2 0.117 1.90 0.96 636.6 320.02 0.826 7.52 × 3.96 × 1.50 × 7.87 × 0.962 96.21 2.68 × mM 10.sup.−5 10.sup.−5 10.sup.2 10.sup.1 10.sup.−2
(87) TABLE-US-00003 TABLE 3 Polarization parameters for various concentrations of Spiro-NO.sub.2 (SP 37) on the C-steel in 1M HC1. βa βc I corr Ecorr Corrosion Chi I corr IE SP 37 V/decade V/decade mA mV Rate mpy Squared mA/cm.sup.2 θ % 0 0.2295 0.3074 1918.0 −345.8 1743 16.65 3815.40 0.000 0.0 mM 0.039 0.2062 0.2714 978.2 −356.4 889.1 30.29 1945.89 0.490 49.0 mM 0.078 0.204 0.2582 524.1 −365.3 476.4 26.51 1042.57 0.727 72.7 mM 0.117 0.1768 0.2218 343.0 −409.6 311.8 51.95 682.32 0.821 82.1 mM
(88) TABLE-US-00004 TABLE 4 Polarization parameters for various concentrations of Spiro-NO.sub.2 complex (CuL) where L = SP 37 on the C-steel in 1M HC1. Corrosion βa βc I corr Ecorr Rate Chi I corr IE CuL V/decade V/decade mA mV mpy Squared mA/cm.sup.2 θ % 0 0.2295 0.3074 1918.0 −345.8 1743 16.65 3815.40 0.000 0.0 mM 0.039 0.1395 0.1780 64.6 −436.5 58.7 27.87 128.45 0.966 96.6 mM 0.078 0.1310 0.1639 35.2 −444.9 31.99 28.77 70.02 0.982 98.2 mM 0.117 0.1220 0.1508 20.6 −450.4 18.73 41.48 41.00 0.989 98.9 mM
Example 5: Spiro-NO.SUB.2 .Derivative (SP 37) (L and CuL)
(89)
(90) The accompanying data can be found in Table 5, below.
(91) TABLE-US-00005 TABLE 5 Phase angles and alpha values (slopes) from the Bode phase and Bode plots for Spiro-NO.sub.2 (L and CuL) at various concentrations. L = SP 37 and CuL 0 mM 0.039 mM 0.078 mM 0.117 mM SP 37 Phase angle ° −55.42 −51.61 −48.21 −55.42 Frequency Hz 252.40 198.60 158.40 252.40 Slope α −0.5434 −0.5819 −0.5309 −0.6332 R.sup.2 0.9902 0.9914 0.9855 0.9949 CuL Phase angle ° −55.42 −68.16 −69.06 −68.78 Frequency Hz 252.40 198.60 198.60 158.40 Slope α −0.5434 −0.7804 −0.7865 −0.7800 R.sup.2 0.9902 0.9994 0.9996 0.9997
Example 6: Spiro-di-Cl Derivative (SP 34) (L and CuL)
(92)
(93) The accompanying data can be found in Tables 6-9, below.
(94) TABLE-US-00006 TABLE 6 Impedance parameters for Spiro-di Cl (SP 34) on the C-steel in 1M HC1 medium by fitting the equivalent circuit model CPE with Diffusion. SP 34 Model CPE Z.sub.CPE with Rs Rs Rp Rp Z.sub.CPE Ω.sup.−1s.sup.n Cdl Cdl IE W Diffusion Ω Ω cm.sup.2 Ω Ω cm.sup.2 n Ω.sup.−1s.sup.n cm.sup.−2 F μF/cm.sup.2 θ % Ss.sup.1/2 0 2.09 1.05 24.13 12.13 0.855 3.27 × 6.50 × 1.44 × 2.86 × 0.000 0.00 6.05E−01 mM 10.sup.-4 10.sup.2 10.sup.−4 10.sup.2 0.037 2.94 1.48 137.7 69.22 0.839 7.09 × 1.41× 2.90 × 5.78 × 0.825 82.48 1.27E+04 mM 10.sup.-5 10.sup.2 10.sup.−5 10.sup.1 0.075 2.65 1.33 419.5 210.88 0.797 5.10 × 1.01× 1.92 × 3.81 × 0.942 94.25 5.50E−02 mM 10.sup.-5 10.sup.2 10.sup.−5 10.sup.1 0.112 2.37 1.19 916.1 460.52 0.798 4.07 × 8.10 × 1.77 × 3.52 × 0.974 97.37 1.39 × mM 10.sup.−5 10.sup.1 10.sup.−5 10.sup.1 10.sup.−2
(95) TABLE-US-00007 TABLE 7 Impedance parameters for Spiro-di-Cl complex (CuL, where L = SP 34) on the C- steel in 1M HCl medium by fitting the equivalent circuit model CPE with Diffusion. CuL Model CPE Z.sub.CPE with Ru Rp Rp Z.sub.CPE Ω.sup.−1s.sup.n Cdl Cdl IE W Diffusion Ω Ω cm.sup.2 Ω Ω cm.sup.2 n Ω.sup.−1s.sup.n cm.sup.−2 F μF/cm.sup.2 θ % Ss.sup.1/2 0 mM 2.09 1.05 24.13 12.13 0.855 3.27 × 6.50 × 1.44 × 2.86 × 0.000 0.00 6.05 × 10.sup.−4 10.sup.2 10.sup.−4 10.sup.−1 0.037 mM 2.60 1.31 642.7 323.09 0.801 3.86 × 7.68 × 1.54 × 3.07 × 0.962 96.25 2.51 × 10.sup.−5 10.sup.1 10.sup.−5 10.sup.1 10.sup.−2 0.075 mM 2.24 1.12 791.5 397.89 0.788 4.05 × 8.05 × 1.61 × 3.20 × 0.970 96.95 1.67 × 10.sup.−5 10.sup.1 10.sup.−5 10.sup.1 10.sup.−2 0.112 mM 2.37 1.19 916.1 460.52 0.798 4.07 × 8.10 × 1.77 × 3.52 × 0.974 97.37 1.39 × 10.sup.−5 10.sup.1 10.sup.−5 10.sup.1 10.sup.−2
(96) TABLE-US-00008 TABLE 8 Polarization parameters for various concentrations of Spiro-di-Cl (SP 34) on the C-steel in 1M HC1. βa βc I corr Ecorr Corrosion Chi I corr SP 34 V/decade V/decade mA mV Rate mpy Squared mA/cm.sup.2 θ IE % 0 mM 0.2295 0.3074 1918.0 -345.8 1743 16.65 3815.40 0.000 0.0 0.037 mM 0.1677 0.2163 183.1 -360.4 166.5 42.74 364.23 0.905 90.5 0.075 mM 0.1419 0.1845 54.7 -385.6 49.72 35.35 108.81 0.971 97.1 0.112 mM 0.1291 0.1924 26.5 -392.9 24.11 31.38 52.76 0.986 98.6
(97) TABLE-US-00009 TABLE 9 Polarization parameters for various concentrations of Spiro-di-Cl complex (CuL where L = SP 34) on the C-steel in 1M HC1. CuL, βa βc I corr Ecorr Corrosion Chi I corr L = SP 34 V/decade V/decade mA mV Rate mpy Squared mA/cm.sup.2 θ IE % 0 mM 0.2295 0.3074 1918.0 −345.8 1743 16.65 3815.40 0.000 0.0 0.037 mM 0.1321 0.1773 28.7 −390.5 26.09 24.6 57.11 0.985 98.5 0.075 mM 0.1224 0.1649 19.1 −399.6 17.34 26.89 37.94 0.990 99.0 0.112 mM 0.1209 0.1604 15.0 −389.3 13.66 30.28 29.90 0.992 99.2
Example 7: Spiro-di-Cl Derivative (SP 34) (L and CuL)
(98)
(99) The accompanying data can be found in Table 10, below.
(100) TABLE-US-00010 TABLE 10 Phase angles and alpha values (slopes) from the Bode phase and Bode plots for Spiro-di Cl (L and CuL, L = SP 34) at various concentrations. L = SP 34 and CuL 0 mM 0.037 mM 0.075 mM 0.112 mM SP 34 Phase angle ° −48.67 −60.64 −64.02 −56.48 Frequency Hz 198.60 315.50 505.50 315.50 Slope α −0.5224 −0.6717 −0.7124 −0.6321 R.sup.2 0.9869 0.9944 0.9979 0.9995 CuL Phase angle ° −48.67 −65.93 −66.30 −66.81 Frequency Hz 198.60 398.00 398.00 315.50 Slope α −0.5224 −0.7371 −0.7391 −0.7518 R.sup.2 0.9869 0.9988 0.9990 0.9996
Example 8: Spiro-Br Derivative (SP 311) (L and CuL)
(101)
(102) The accompanying data can be found in Tables 11-14, below.
(103) TABLE-US-00011 TABLE 11 Impedance parameters for Spiro-Br (SP 311) on the C-steel in 1M HC1 medium by fitting the equivalent circuit model CPE with Diffusion. SP 311 Model CPE Z.sub.CPE with Rs Rs Rp Rp Z.sub.CPE Ω.sup.−1s.sup.n Cdl Cdl IE W Diffusion Ω Ω cm.sup.2 Ω Ω cm.sup.2 n Ω.sup.−1s.sup.n cm.sup.−2 F μF/cm.sup.2 θ % Ss.sup.1/2 0 mM 2.52 1.27 21.23 10.67 0.855 3.56 × 7.08 × 1.56 × 3.10 × 0.000 0.00 5.42 × 10.sup.−4 10.sup.2 10.sup.−4 10.sup.2 10.sup.−4 0.036 mM 2.49 1.25 18.58 9.34 0.860 3.41 × 6.77 × 1.49 × 2.97 × — — 9.75 × 10.sup.−4 10.sup.2 10.sup.−4 10.sup.2 0.143 14.26 10.sup.−1 0.073 mM 2.39 1.20 23.32 11.72 0.854 3.26 × 6.48 × 1.41 × 2.81 × 0.090 8.96 9.08 × 10.sup.−4 10.sup.2 10.sup.−4 10.sup.2 10.sup.−1 0.109 mM 3.00 1.51 57.21 28.76 0.834 1.37 × 2.72 × 5.21 × 1.04 × 0.629 62.89 7.93 × 10.sup.−4 10.sup.2 10.sup.−5 10.sup.2 10.sup.−1
(104) TABLE-US-00012 TABLE 12 Impedance parameters for Spiro-Br (CuL, L = SP 311) on the C-steel in 1M HCl medium by fitting the equivalent circuit model CPE with Diffusion. CuL Model CPE Z.sub.CPE with Rs Rs Rp Rp Z.sub.CPE Ω.sup.−1s.sup.n Cdl Cdl IE W Diffusion Ω Ω cm.sup.2 Ω Ω cm.sup.2 n Ω.sup.−1s.sup.n cm.sup.−2 F μF/cm.sup.2 θ % Ss.sup.1/2 0 2.52 1.27 21.23 10.67 0.855 3.56 × 7.08 × 1.56 × 3.10 × 0.000 0.00 5.42 × mM 10.sup.−4 10.sup.2 10.sup.−4 10.sup.2 10.sup.−1 0.036 2.94 1.48 254.4 127.89 0.797 1.02 × 2.03 × 4.02 × 7.99 × 0.917 91.65 6.51 × mM 10.sup.−4 10.sup.2 10.sup.−5 10.sup.1 10.sup.−2 0.073 2.65 1.33 345.1 173.48 0.786 9.31 × 1.85 × 3.65 × 7.26 × 0.938 93.85 4.71 × mM 10.sup.−5 10.sup.2 10.sup.−5 10.sup.1 10.sup.−2 0.109 2.69 1.35 435.7 219.03 0.807 5.80 × 1.15 × 2.28 × 4.53 × 0.951 95.13 3.20 × mM 10.sup.−5 10.sup.2 10.sup.−5 10.sup.1 10.sup.−2
(105) TABLE-US-00013 TABLE 13 Polarization parameters for various concentrations of Spiro-Br (SP 311) on the C-steel in 1M HC1. SP βa βc I corr Ecorr Corrosion Chi I corr 311 V/decade V/decade mA mV Rate mpy Squared mA/cm.sup.2 θ IE % 0 0.2468 0.3293 2237.0 −345.9 2034 13.4 4449.97 0.000 0.0 mM 0.036 0.2462 0.3398 2271.0 −326 2064 16.74 4517.60 −0.015 −1.5 mM 0.073 0.236 0.3194 1946.0 −340.6 1769 16.56 3871.10 0.130 13.0 mM 0.109 0.1828 0.247 412.4 −346.5 374.9 33.61 820.37 0.816 81.6 mM
(106) TABLE-US-00014 TABLE 14 Polarization parameters for various concentrations of Spiro-Br (CuL, L = SP 311) on the C-steel in 1M HC1. βa βc I corr Ecorr Corrosion Chi I corr CuL V/decade V/decade mA mV Rate mpy Squared mA/cm.sup.2 θ IE % 0 mM 0.2468 0.3293 2237.0 −345.9 2034 13.4 4449.97 0.000 0.0 0.036 mM 0.1498 0.1929 90.8 −378.8 82.56 27.06 180.68 0.959 95.9 0.073 mM 0.1436 0.1875 67.6 −384.1 61.43 25.7 134.43 0.970 97.0 0.109 mM 0.1394 0.1779 46.0 −386.6 41.83 23.23 91.55 0.979 97.9
Example 9: Spiro-Br Derivative (SP 311) (L and CuL)
(107)
(108) The accompanying data can be found in Table 15, below.
(109) TABLE-US-00015 TABLE 15 Phase angles and alpha values (slopes) from the Bode phase and Bode plots for Spiro-Br (L and CuL, L = SP 311) at various concentrations. L = SP 311 and CuL 0 mM 0.036 mM 0.073 mM 0.109 mM SP Phase −44.86 −43.50 −46 68 −53.23 311 angle ° Frequency 198.60 198.60 198.60 315.50 Hz Slope α −0.5382 −0.4465 −0.5577 −0.5999 R.sup.2 0.99392 0.97417 0.99354 0.98763 CuL Phase −44.86 −61.59 −61.09 −61.02 angle ° Frequency 198.60 198.60 198.60 198.60 Hz Slope α −0.5382 −0.7196 −0.7274 −0.7423 R.sup.2 0.99392 0.9992 0.9995 0.9987
Example 10: Adsorption Studies
(110) The adsorption mechanism of the inhibitors Spiro compounds and copper complexes on the surface of C-steel were studied by three models using the anticorrosion % inhibition data from Tafel plots, as shown in
(111) The accompanying data, summarizing the anticorrosion results, can be found in Tables 16-18, below.
(112) TABLE-US-00016 TABLE 16 % inhibition % Langmuir Temkin Frumkin from inhibition Model Model Model A) Samples Impedance from Tafel (R.sup.2) (R.sup.2) (R.sup.2) L = SP 37 56.53 82.1 0.9900 0.9995 0.8963 L = SP 34 96.97 98.6 0.9998 0.9649 0.9684 L = SP 311 62.89 81.6 0.2679 — — CuL, 96.21 98.9 1.00 0.8563 0.3198 SP 37 cpx CuL, 97.37 99.2 1.00 0.9555 0.9610 SP 34 cpx CuL, 95.13 97.9 0.9999 0.954 0.6368 SP 311 cpx
(113) TABLE-US-00017 TABLE 17 B) Samples % Inhibition from Impedance studies L SP 34 (96.97%) > SP 311 (62.89%) > SP 37 (56.53%) CuL CuL, SP 34 cpx (97.37%) > CuL, SP 37 cpx (96.21%) > CuL, SP 311 cpx (95.13%)
(114) TABLE-US-00018 TABLE 18 C) Samples % Inhibition from Tafel plots L SP 34 (98.6%) > SP 37 (82.1%) > SP 311 (81.6%) CuL CuL, SP 34 cpx (99.2%) > CuL, SP 37 cpx (98.9%) > CuL, SP 311 cpx (97.9%)
(115) It is to be understood that the spirooxindole compounds and associated copper complexes are not limited to the specific embodiments described above, but encompasses any and all embodiments within the scope of the generic language of the following claims enabled by the embodiments described herein, or otherwise shown in the drawings or described above in terms sufficient to enable one of ordinary skill in the art to make and use the claimed subject matter.