NEW DELIVERY SYSTEM

Abstract

The present invention relates to a new delivery system for nutritional ingredients (nutraceuticals). These nutritional ingredients are useful for gut and metabolic health in monogastric animals, especially in humans.

Claims

1. Delivery system consisting of (a) a solid core, which comprises at least one nutraceutical, and (b) an inner coating comprising at least one fermentable biopolymer, which is crosslinked, and (c) an outer coating which is resistant to stomach conditions and releasing in the small intestine.

2. Delivery system according to claim 1, wherein the at least one nutraceutical is chosen from the group consisting of organic acids, omega 3 fatty acids, omega 6 fatty acids, omega 8 fatty acids, long chain fatty acids, polyphenols (such as resveratrol or genistein), prebiotics, probiotics, essential oils, or antimicrobial peptides.

3. Delivery system according to claim 1, wherein the nutraceutical is propionic acid (and/or salts thereof) or butyric acid (and/or salts thereof).

4. Delivery system according to claim 1, wherein the material of the inner coating is chosen from group consisting of alginate, chitosan, pectin, cyclodextrin as well as other gums.

5. Delivery system according to claim 1, wherein the inner coating layer is crosslinked with Mg and/or Ca ions.

6. Delivery system according to claim 1, wherein the outer coating is chosen from group consisting of shellac, methacrylate copolymers and fats.

7. Process of production delivery systems claim 1, wherein the process is carried out batch-wise.

8. Process of production delivery systems according to claim 1, wherein the process is carried out continuously.

9. Process for the production of a premix, dietary supplement, food product, feed product, personal care product or pharmaceutical product using at least one delivery system according to claim 1.

10. Premix, dietary supplement, food product, feed product, personal care product or pharmaceutical product comprising at least one delivery system according to claim 1.

Description

EXAMPLES

Example 1

[0073] 30 g Na alginate (grinsted sodium alginate) are dissolved in 1500 g water at 50° C. with stirring. 3.2 g Ca chloride dihydrate is dissolved in 407 g water. 200 g Ca Propionate (Sigma-Aldrich) is filled in a fluid-bed processor (WFP mini, DMR, Wurster configuration). All coating steps were performed at a product temperature of about 40° C. The alginate solution is sprayed on the fluidized Ca propionate powder first. After spraying of the alginate solution, the feeding tube is briefly rinsed with water. The Ca chloride solution is sprayed on the inner coating at 40° C. for hardening. After the hardening solution, 400 g aqueos shellac preparation with a solids content of 25% (Marcoat 125N) is sprayed as outer coating. After spraying of the shellac, the product is dried in the fluid bed. 324 g coated granules were obtained.

[0074] Composition of the final coated granulate was 60% Ca-propionate, 9% alginate, 1% Ca chloride and 30% shellac.

[0075] Protection of propionate under stomach conditions was tested with 0.1N HCl at 37.5° C. using a USP-1 (SOTAX) apparatus. After 2 hours only 12% of the propionate was released.

Example 2: Comparative Example without Hardening the Inner Layer

[0076] Ca-propionate was coated similar to example 1, skipping the hardening step (spraying of Ca chloride). Composition of the final coated granulate was 58% Ca-propionate, 7% Na alginate and 35% shellac.

[0077] Protection of propionate under stomach conditions was tested with 0.1N HCl at 37.5° C. using a USP-1 (SOTAX) apparatus. After 2 hours 58% of the propionate was released.