Patch with active ingredients

Abstract

The invention relates to a patch (2) with at least one filler and at least one active ingredient, wherein the local distribution of the active ingredient or ingredients within the patch (2) takes place dependent on the morphology, anatomy and physiology of the lesion (1) to be treated.

Claims

1. A patch with a plurality of fillers and at least one active ingredient, wherein a local distribution of the at least one active ingredient within the patch (2) takes place dependent on a morphology, anatomy and physiology of a lesion (1) to be treated; and wherein the patch comprises the plurality of fillers contained in a plurality of compartmentscontainingtheatleastoneactiveingredientandformedinthepatchtocovera plurality of different regions of the lesion (1); wherein at least one of the plurality of fillers having multiple layers to devise a different dissolution rate from other fillers of the plurality of fillers.

2. A patch according to claim 1 wherein at least one of the plurality of compartments having a different active ingredient from the other compartments of the plurality of compartments.

3. The patch according to claim 1, wherein the patch (2) comprises at least one backing material (3).

4. The patch according to claim 1, wherein the patch (2) comprises at least one shielding material.

5. The patch according to claim 1, wherein the at least one active ingredient comprises a radionuclide or an active substance, the radionuclide being selected from radionuclides emitting α-, β- or γ-radiation and/or from stable nuclides.

6. A method for producing a patch (2) according to claim 1, comprising the following steps: (A1) creating a digital model of the lesion (1) to be treated using data obtained by means of imaging methods, (B1) dividing the lesion (1) into partial regions according to definition, (C1) determining at least one substance necessary for each partial region of the lesion (1) such as at least one of the plurality of fillers and at least one active ingredient, (D1) preparing the patch (2) using the at least one substance determined according to step (C1), (E1) if applicable, activating stable nuclides by energy-rich neutron irradiation.

7. The method for producing a patch (2) according to claim 6, wherein at least the preparation of the patch (2) according to step (D1) takes place by a 3D printing process.

8. Method for producing a patch (2) according to claim 1, comprising the following steps: (A2) creating a digital model of the lesion (1) to be treated using data obtained by means of imaging methods, (B2) dividing the lesion (1) into partial regions according to definition, (C2) determining at least one substance necessary for each partial region of the lesion (1) such as at least one of the plurality of fillers and at least one active ingredient, (D2) preparing the patch (2) using the at least one of the plurality of fillers determined according to step (C2) for creating a compartmentalized patch (2), and (E2) filling at least one compartment of the compartmentalized patch (2) with the at least one active ingredient and if applicable further of the at least one of the plurality of fillers determined according to step (C), (F2) if applicable, activating stable nuclides by energy-rich neutron irradiation.

9. A method for producing a patch (2) according to claim 6, wherein after step (D) or (step (E1), in a further step (D1′) or (E1′) respectively, a further backing material (3) and/or shielding layer is applied.

10. A method for producing a patch (2) according to claim 9, wherein after step (D2), step (E2) or step (F2), in a further step (D2′), (E2′) or (F2′) respectively, a further backing material (3) and/or shielding layer is applied.

11. A method for producing a patch (2) according to claim 9, wherein at least the preparation of the patch (2) according to step (D2) takes place by a 3D printing process.

Description

BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS

(1) FIG. 1A is a diagrammatic representation of a lesion divided into varying partial regions;

(2) FIG. 1B is a diagrammatic representation of the patch manufactured for the lesion of FIG. 1A;

(3) FIG. 1C is a diagrammatic view of the patch of FIG. 1B with a further backing material.

DESCRIPTION OF SPECIFIC EMBODIMENTS OF THE INVENTION

(4) FIG. 1A shows a diagrammatic two-dimensional view of a lesion 1, for example a skin tumor. Such a model of the lesion to be treated is based for example on data obtained by means of imaging methods. This data is suitable also for creating a three-dimensional model, which will not be discussed at this point solely for reasons of clarity.

(5) The model of the lesion is divided into partial regions. This can be done solely by the assessment of a person skilled in the art or alternatively with the aid of a computer. The regions thus defined correspond for example to a previously defined severity of the respective disease, for example a particular tumor stage, a particular cell density, etc., as made clear by the Roman numerals I to III, and require individual treatment in each case. The differentiation may understandably comprise substantially more degrees than only the I to III shown by way of example.

(6) In the present case, the lesion 1 has been divided into six partial regions, of which one partial region corresponds to definition I, three partial regions to definition II and two partial regions to definition III.

(7) FIG. 1B shows a patch 2 prepared for the lesion 1 according to FIG. 1A. The patch 2 contains, for each of the partial regions of the lesion, a specific loading with active ingredients which are matched in each case precisely to the necessary treatment of the respective partial region and are designated A, B and C. The differentiation may of course comprise substantially more treatment possibilities than the A, B and C shown by way of example. Alternatively, it is conceivable for the patch initially to comprise solely the fillers and to be divided into the compartments A, B and C, which are only laden with the active ingredients provided in each case in a further step.

(8) Preferably such a patch 2 is produced by means of 3D printing processes. Accordingly, it is conceivable that the data obtained by means of imaging methods is evaluated by a computer using the previously defined degrees of severity of the lesion (here I to III), and this data is then transmitted to a 3D printer. A 3D printer programmed with correspondingly defined treatments (here A to C) and provided with corresponding substances will then be able to print a corresponding patch.

(9) FIG. 1C shows the patch 2 of FIG. 1B, with a carrier layer 3 having been applied on or if applicable also around the patch 2. Thus, the patch 2 can be applied for example as a medical plaster. A shielding layer can be provided as a further layer (not shown).

LIST OF REFERENCE CHARACTERS

(10) 1 lesion 2 patch 3 backing material I-III defined degrees of severity A-C defined loading