THERAPEUTIC COMPOSITION FOR ENDOMETRIOSIS SURGERY AND METHOD FOR USING THE SAME

Abstract

The present invention provides a therapeutic composition for administering during a surgery, especially an endometriosis surgery, comprising at least an active ingredient and an excipient, wherein the active ingredient comprises an antioxidant agent and the excipient comprises a semi-solid barrier. The present invention provides also a method for using such a therapeutic composition during a surgery.

Claims

1. Therapeutic composition for administering during a surgery, especially an endometriosis surgery, comprising at least an active ingredient and an excipient, wherein said active ingredient comprises an antioxidant agent and said excipient comprises a semi-solid barrier.

2. Therapeutic composition according to claim 1, wherein said semi-solid barrier is formed as gel or hydrogel or sprayable hydrogel or supramolecular polymeric hydrogel.

3. Therapeutic composition according to claim 1, further comprising a haemostatic agent.

4. Therapeutic composition according to claim 1, wherein said antioxidant agent comprises Methylene Blue.

5. Therapeutic composition according to claim 1, further comprising Vitamin C or one of the Vitamins C, E and A or a combination thereof.

6. Therapeutic composition according to claim 1, wherein said haemostatic agent comprises a local vasoconstructive agent or Vasopressin.

7. Therapeutic composition according to claim 1, wherein said active ingredient further comprises a local anesthetic or Lidocain.

8. Method for administering a therapeutic composition during a surgery, especially an endometriosis surgery, comprising excising a site and covering said site of excision with a therapeutic composition comprising at least an active ingredient and an excipient, wherein said active ingredient comprises an antioxidant agent and said excipient comprises a semi-solid barrier.

9. Method according to claim 8, wherein covering said site of excision with said therapeutic composition comprises injecting or spraying said therapeutic composition onto said site of excision.

10. Method according to claim 8, wherein said site of excision is left covered with said therapeutic composition after the surgery.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0013] The accompanying drawings, referred to herein and constituting a part hereof, illustrate preferred embodiments of the present invention and together with the description, serve to explain the principles of the present invention, wherein:

[0014] FIG. 1 is a partial cross-sectional side view of a peritoneum of a patient schematically showing an excision site before removal of endometriosis;

[0015] FIG. 2 is a partial cross-sectional side view of a peritoneum schematically showing an excision site after removal of endometriosis;

[0016] FIG. 3 is a partial cross-sectional side view of a peritoneum schematically showing an embodiment of the present invention administered onto an excision site of endometriosis.

DESCRIPTION OF AN EXEMPLARY EMBODIMENT

[0017] Referring to FIG. 1, a body tissue in the peritoneum (4) of a female body is illustrated in cross-sectional view before excision removal of endometriosis, showing an endometriosis (1), and contracted ureter (2), nerve (3), rectum (5) because of the developed endometriosis. FIG. 1 shows also an excision site (7) and surgical tools for removal of endometriosis (1).

[0018] FIG. 2 shows that the contraction of ureter (2), nerve (3) and rectum (5) is released after excision removal of endometriosis leaving an open excision site (7).

[0019] FIG. 3 shows the excision site (7) of FIG. 2 now covered with the inventive therapeutic composition comprising a semi-solid barrier as a vehicle and excipient for retarded release. According to this embodiment, the semi-solid barrier was formed as hydrogel, which was then sprayed onto the excision site (7) so as to cover the excision site (7). The surgery was then completed leaving the excision site (7) covered with the therapeutic composition. Alternatively, the inventive composition may have been injected instead of sprayed onto the excision site (7).

[0020] While the above description contains many specifics, these specifics should not be construed as limitations on the scope of the invention, but merely as exemplifications of preferred embodiments thereof. Those skilled in the art will envision many other possible variations that are within the scope and spirit of the invention as defined by the claims appended hereto.