RF MICROCHIP FOR INDUCTION OF CANCER CELL MIGRATION FOR MICROWAVE THERMAL TREATMENT OR REMOVAL SURGERY

Abstract

The present invention relates to a device for inducing migration of cancer cells for cancer treatment, comprising an RF absorber including an antenna for irradiating a frequency of a specific band to a living tissue including cancer cells; a method for inducing migration of cancel cells using the same; and a method for cancer treatment.

Claims

1. A device for inducing migration of cancer cells for cancer treatment, the device comprising an RF absorber including an antenna for radiating a frequency in a range of 13 to 14 MHz to a living tissue including cancer cells, wherein the frequency radiated from the antenna induces migration of the cancel cells.

2. The device according to claim 1, wherein the RF absorber radiates a frequency of 13.56 MHz to the living tissue.

3. The device according to claim 1, wherein the RF absorber is implanted in or attached to a surface of one end of the living tissue.

4. The device according to claim 1, wherein the RF absorber moves the cancer cells to an area at one side of the living tissue, where the RF absorber is implanted or attached.

5. The device according to claim 1, wherein the RF absorber includes a power supplier, an LC oscillator configured to have an inductor (L) and a capacitor (C), a modulator using any one modulation method among AM, FM, ASK, and FSK, a bandpass filter having a center frequency existed in a range of 13 to 14 MHz and a bandwidth of 1 to 2 MHz, an amplifier for amplifying a signal having a frequency in a range of 13 to 14 MHz, and an antenna.

6. The device according to claim 1, wherein the cancer is a solid cancer.

7. The device according to claim 1, wherein the cancer is any one selected from a group including skin cancer, liver cancer, colorectal cancer, cervical cancer, kidney cancer, stomach cancer, prostate cancer, breast cancer, brain tumor, lung cancer, uterine cancer, colon cancer, bladder cancer, and pancreatic cancer.

8. A method for inducing migration of cancer cells, the method comprising the step of generating a frequency in a range of 13 to 14 MHz by operating an RF absorber implanted in or attached to a living tissue including cancer cells.

9. The method according to claim 8, wherein the frequency is 13.56 MHz.

10. The method according to claim 8, wherein the cancer cells are moved to an area at one side of the living tissue, where the RF absorber is implanted or attached.

11. The method according to claim 8, wherein the cancer is a solid cancer.

12. The method according to claim 8, wherein the cancer is any one selected from a group including skin cancer, liver cancer, colorectal cancer, cervical cancer, kidney cancer, stomach cancer, prostate cancer, breast cancer, brain tumor, lung cancer, uterine cancer, colon cancer, bladder cancer, and pancreatic cancer.

13. A method for cancer treatment, the method comprising the steps of: (a) generating a frequency in a range of 13 to 14 MHz by operating an RF absorber implanted in or attached to a living tissue including cancer cells; and (b) removing cancer cells moved by the frequency.

14. The method according to claim 13, wherein the step of removing cancer cells is selected among a surgical operation, a microwave thermal treatment of 41 to 46° C., radiation of an RF frequency of the RF absorber, and a combination of these.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0025] FIG. 1 a view showing exemplary structures and shapes of an RF absorber according to a specific embodiment.

[0026] FIG. 2 a schematic view showing the circuit of an RF absorber according to a specific embodiment.

[0027] FIG. 3 a view showing the operation process of an RF absorber according to a specific embodiment.

[0028] FIG. 4 a view illustrating a method for treating cancer according to a specific embodiment, which schematically shows a series of processes of inducing migration of cancer cells by using a device according to the specific embodiment, and then resecting a tissue related thereto.

[0029] FIG. 5 a view illustrating a method for cancer treatment according to a specific embodiment, which schematically shows a series of processes of inducing migration of cancer cells by using a device according to the specific embodiment, and then performing RF thermal treatment on a tissue related thereto.

[0030] FIG. 6 a view illustrating a method for cancer treatment according to a specific embodiment, which schematically shows a series of processes of inducing migration of cancer cells by using a device according to the specific embodiment, and then radiating an RF frequency on a tissue related thereto.

[0031] FIG. 7 a view comprehensively showing a method of treating cancer according to a specific embodiment, which schematically shows a series of processes of inducing migration of cancer cells in various living tissues using a device according to the specific embodiment, and then performing I. Resection (surgery removal), II. microwave thermal treatment using RF frequency (heater killing), and III. Radiation of RF frequency and focused ultrasound (Microwave/RF/Focus Ultrasound killing) on a tissue related thereto.

[0032] FIG. 8 a view showing a result of counting cancer cells moved to an area irradiated with an RF frequency of about 13.56 MHz after radiating the RF frequency to a tissue having cancer cells for 20 hours (Control: Group not irradiated with RF frequency, Treated: Group irradiated with RF frequency).

[0033] FIG. 9 a view showing a result of confirming changes in the expression of factors related to motility or mobility in cancer cells after radiating an RF frequency of 13.56 MHz to a tissue having cancer cells for 20 hours (Control: Group not irradiated with RF frequency, Treated: Group irradiated with RF frequency).

DETAILED DESCRIPTION OF THE INVENTION

[0034] Hereafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

[0035] The following embodiments are provided to more completely describe the present invention to those skilled in the art, and the following embodiments may be modified in various other forms, and the scope of the present invention is not limited to the following embodiments.

[0036] The terms used in this specification are used to describe specific embodiments and are not intended to limit the present invention. As used in this specification, singular forms may include plural forms unless the context clearly indicates other cases. In addition, when used herein, “comprise, include” and/or “comprising, including” specifies existence of mentioned shapes, numbers, steps, actions, members, elements, and/or groups thereof, and does not preclude the presence or addition of one or more other shapes, numbers, actions, members, elements and/or groups.

[0037] The present invention provides an RF microchip for inducing migration of cancer cells for microwave thermal treatment using RF frequency of 41 to 46° C. or removal surgery by using an RF absorber for radiating a frequency of 10 to 200 mW and 13 to 14 MHz (e.g., 13.56 MHz) to a living tissue including cancer cells of solid cancer.

[0038] FIGS. 1 and 2 are views showing exemplary structures and shapes of an RF absorber and a schematic view of an RF circuit according to a specific embodiment.

[0039] The RF absorber according to an embodiment is a device for generating a frequency in a range of 13 to 14 MHz, more specifically, 13.56 MHz, and radiating the frequency to a living tissue, and may be manufactured in various materials and shapes known in the art. For example, it may be provided in the form of a chip of a micro unit having a shape of circular cylinder or square cylinder. In addition, the RF absorber may include an antenna for transmitting a frequency to a living tissue, and the antenna may include a cavity backed log spiral conductive structure to form a frequency of a specific band. In addition, the RF absorber may be provided in the form of a microchip, and the integrated circuit of the RF absorber includes a power supplier, an LC oscillator configured of an inductor (L) and a capacitor (C), a modulator using any one modulation method among AM, FM, ASK, and FSK, a bandpass filter having a center frequency of 13 to 14 MHz and a bandwidth of 1 to 2 MHz, an amplifier for amplifying a signal having a frequency of 13 to 14 MHz, and an antenna, which are mounted on the microchip, and is manufactured as a hybrid MIC, an MMIC or an SoC.

[0040] In addition, the RF absorber is provided with a micro LED driving circuit or an optical fiber driving circuit, and may further include a micro LED or an optical fiber for radiating near infrared (NIR) rays having a wavelength of 470 nm to 700 nm reaching the inside of a living tissue.

[0041] In addition, the RF absorber may further include a mixer, a power divider, a Balun filer or the like as needed, and a control unit and a Bluetooth communication unit of the RF absorber, which are known in the art and involved in the ON/OFF operation of the RF absorber, may be separately provided.

[0042] FIG. 3 a view showing the operation process of an RF absorber according to a specific embodiment.

[0043] The RF absorber according to an embodiment may be used while facing or being implanted in or attached to the living tissue, and at this point, the frequency of a specific band radiated from the antenna of the RF absorber, for example, a frequency of 13.56 MHz, may have an effect of reducing a lesion site by moving cancer cells widely distributed throughout a living tissue to a local area, for example, an area at one side of the living tissue, where the RF absorber is implanted or attached.

[0044] FIGS. 4 to 6 are views respectively illustrating a method of treating cancer according to a specific embodiment, which schematically shows a series of processes of inducing migration of cancer cells using a device according to the specific embodiment, and then resecting a tissue related thereto (FIG. 4), performing RF thermal treatment of 41 to 46° C. (FIG. 5), and radiating an RF frequency and focused ultrasound (FIG. 6).

[0045] The method for cancer treatment according to an embodiment may include the steps of: (a) transferring a frequency in a range of 13 to 14 MHz (e.g., 13.56 MHz) to a living tissue including cancer cells by operating an RF absorber implanted in or attached to the living tissue; and (b) removing the cancer cells. At step (a), lesion sites may be reduced by moving the cancer cells widely distributed throughout the living tissue to a local area, for example, an area at one side of the living tissue, where the RF absorber is implanted or attached. Step (b) may mean all sorts of behaviors for killing the cancer cells or reducing their functionality, as well as separating the cancer cells from normal tissues in the living tissue. For example, to separate the cancer cells from normal tissues in the living tissue, a surgical operation, i.e., a surgical resection, may be applied (see FIG. 4). To kill the cancer cells or to reduce their functionality, microwave thermal treatment of 41 to 46° C. or radiation of RF frequency may be applied.

[0046] FIG. 7 a view comprehensively illustrating a method of treating cancer according to a specific embodiment, which schematically shows a series of processes of inducing migration of cancer cells in various living tissues using a device according to the specific embodiment, and then performing I. Resection, II. microwave thermal treatment using RF frequency, and III. Radiation of RF frequency and focused ultrasound on a tissue related thereto.

[0047] The cancer treatment method according to an embodiment may be applied to a living tissue including cancer cells, and may be applied to cancer cells existing in tissues of, for example, skin, liver, large intestine, cervix, kidney, stomach, prostate, breast, brain, lung, uterus, colon, bladder, and pancreatic. In addition, when it is needed, a local treatment of cancer may be applied individually, or both the local treatment and systemic treatment may be applied simultaneously, separately, or sequentially.

[0048] Hereinafter, the present invention will be described in more detail through embodiments. However, these embodiments are for illustrative purposes, and the scope of the present invention is not limited to these embodiments.

EMBODIMENTS

Embodiment 1. Migration of Cancer Cells by RF Frequency

[0049] In this embodiment, it is attempted to confirm the effect of RF frequency on the migration of cancer cells. Specifically, using an RF absorber according to an embodiment, an RF frequency of 13.56 MHz is radiated for 20 hours on a tissue in which cancer cells exist. Thereafter, cancer cells moved to an area irradiated with the RF frequency are counted, and changes in the expression of factors related to motility or mobility in the cancer cells are evaluated. WM cells or G361 cells known as skin cancer cells are used as the cancer cells, and a group not irradiated with the RF frequency is set as a control group.

[0050] As a result, as shown in FIG. 8, it can be confirmed in both the WM cells and the G361 cells that a large number of cancer cells move to the area irradiated with the RF frequency, and this effect is remarkable compared to that of the control group. In addition, as shown in FIG. 9, the RF frequency improves the factors related to mobility of the cancer cells, such as EGF, FGF, and the like.

[0051] From the experiment result like this, it is known that cancer cells can be moved to an area on a surface of one end of a living tissue by applying a frequency in a range of 13 to 14 MHz to the living tissue, and therefore, cancer cells or tissues can be removed effectively.

[0052] The above description of the present invention is for illustrative purposes only, and those skilled in the art may understand that the present invention can be easily modified into another specific form without changing the technical spirit or essential features of the present invention. Therefore, it should be understood that the embodiments described above are illustrative and not restrictive in all respects.