RACK FOR AUTOMATED ANAYLZER

Abstract

A rack for automated analyser systems and provides a rack for automated analyser systems, the rack comprising a main body having an extended front side and a corresponding extended reverse side as well as at least two side walls defining at least one opening that is accessible from the main body's upper side for taking up a container for a sample that is to be processed; an upper insert that is arranged onto an upper end of the main body, wherein the upper insert has openings with a predefined diameter defining the upper surface of the rack.

Claims

1. A rack for automated analyser systems, the rack comprising a main body having an extended front side and a corresponding extended reverse side as well as at least two side walls defining at least one slot with at least one first opening that is accessible from the main body's upper side for taking up a container for a sample that is to be processed; an upper insert that is arranged onto an upper end of the main body, wherein an upper surface of the upper insert has at least one second opening with a predefined diameter defining the upper surface of the rack.

2. The rack of claim 1, wherein the main body comprises recesses which are substantially horizontally arranged in the at least two side walls of the at least one first opening for inserting horizontally a lower insert.

3. The rack of claim 1, further comprising a lower insert that is inserted into opposite recesses in the at least two side walls in the at least one first opening.

4. The rack of claim 1, wherein the lower insert has a horizontal surface with at least one third opening for centring tubes passing said at least one first and second opening or wherein the lower insert has a horizontal surface for reducing the available height of the at least one first and second opening going from said horizontal surface of the lower insert to the upper end of the upper insert.

5. The rack of claim 1, wherein the at least second opening of an upper insert has a predefined geometry selected from the group comprising circular, elliptic, rectangular, quadratic or rhomboid.

6. The rack of claim 1, wherein the main body is made of an electrically conductive material.

7. The rack of claim 1, wherein at least two lower inserts with at least one third opening are placed in the at least one first opening.

8. The rack of claim 1, wherein the reverse side has a position for an RFID tag.

9. The rack of claim 1, wherein the front side and/or a smaller end wall has a position for barcodes.

10. The rack of claim 1, wherein the smaller end wall comprises a magnet for detection of the rack.

11. The rack of claim 1, wherein the at least one second opening of the upper insert comprises a whole tube insert having a smaller volume than the slot for taking up receptacles.

12. The rack of claim 1, wherein the rack has at its underside at least one recess for taking up protrusions of a conveyer belt.

13. The use of a rack according to claim 1 in automated analyser systems for processing, analysing or diagnosing samples.

Description

BRIEF DESCRIPTION OF THE FIGURES

[0026] The invention will be described based on figures. It will be understood that the embodiments and aspects of the invention described in the figures are only examples and do not limit the protective scope of the claims in any way. The invention is defined by the claims and their equivalents. It will be understood that features of one aspect or embodiment of the invention can be combined with a feature of a different aspect or aspects of other embodiments of the invention, in which:

[0027] FIG. 1 shows a perspective view onto an extended front side of a rack.

[0028] FIG. 2 shows a perspective view onto an extended reverse side of a rack.

[0029] FIGS. 3A, 3B and 3C show different embodiments of upper inserts.

[0030] FIG. 4 shows an embodiment of a lower insert.

[0031] FIG. 5 shows a rack with a whole tube insert.

[0032] FIG. 6 shows sectional views of the whole tube insert.

[0033] FIG. 7 shows a part of a rack with a hanging tube and two open lower inserts.

[0034] FIG. 8 shows a rack onto a conveyer belt.

[0035] FIG. 9 shows the lower side of a rack.

DETAILED DESCRIPTION OF THE INVENTION

[0036] The technical problem is solved by the technical features of the independent claims. The dependent claims cover further specific embodiments of the invention.

[0037] The main body of a rack has at least one slot or compartment (or having multiple slots or compartments) with at least one first opening (or multiple openings) at the upper end, wherein a slot or compartment is substantially vertical so that a receptacle can be inserted. A receptacle according to the invention comprises a reaction vessel or tube like a sample tube, container, bottle or test tube for taking up a liquid.

[0038] A sample, reaction mixture or patient sample according to the present invention designates a liquid that is to be processed, analyzed or diagnosed. A sample may be liquid or a liquid that comprises solids like beads, e.g. magnetic beads. A sample may be or comprise a body liquid or parts of it comprising for instance blood, plasma, urine that have been retrieved before.

[0039] The present invention provides a rack that allows to load and carry tubes of different sizes and shapes according to the CLSI standards. The upper end of the rack carries an upper insert with at least one second opening having a diameter adapted to the receptacle that is inserted into the slot. The advantage of a rack according to the present invention is that the costs for manufacturing of racks and their purchase are reduced. In addition, a lab gets a fully configured rack, that can be used for racks of different sizes and shapes which makes the handling of tubes by far easier for a user.

[0040] It is particularly important to provide a rack that keeps the tubes centered in a so-called receiving position of the rack so that liquids can be reliably removed from the respective tube even when tubes with different diameters are to be processed by a pipetting robot.

[0041] A rack according to the present invention allows furthermore the reading of barcodes attached on the rack as well as the recognition of various tube parameters, e.g. diameter, height, lid type, lid color, level or phase transitions. The rack has further features that enable a good manual and automated handling which are described below.

[0042] It is envisaged that an appropriate material for the rack can be chosen, comprising the use of electrically conductive plastics so that capacitive liquid level detection (CLLD) in the tubes will be possible.

[0043] The core of the present invention refers to a modular design in terms of a multi part design for supporting different tube diameters in a single rack. The rack may also be adaptable to different heights of tubes. The rack may further be made of an electrically conductive material. Further features of a rack according to the invention refer to cut-outs or windows in the surface of the front side, along a slot into which the tubes are placed so that measuring processes may be performed through the cut-out or window while a tube is placed into a rack's slot. In order to allow illumination or excitation of fluorescence in a sample, a reverse side opposite the front side of the rack may also have cut-outs or windows.

[0044] The racks according to the present invention can be labelled with a RFID tag for providing information like the content of a tube, a location within an automated analyzer where the tube or all tunes of a rack have to be transported or about the respective analytical assay that has to be performed with the content of a tube or the tubes of a rack.

[0045] The requirement to allow placement of several tube of a different type in terms of their size and/or shape types in one rack is solved by the modular design. A main body of a rack, which always remains the same, has certain vertical spaces or slots for accommodating a receptacle like a tube, and the adaptation to different types of tubes is achieved by means of specific inserts.

[0046] FIG. 1 shows a front side of a rack 1 with an upper insert 5, which is located at the top of the rack 1 for adapting the diameter of the upper openings of a slot 3 to different tube diameters with second openings 7. It is intended that an upper insert 5 provides second openings 7 for diameter certain ranges, e.g. from 10 mm to 13 mm or 13 mm to 16 mm.

[0047] The second openings 7 of the upper inserts 5 may also have a specific geometry allowing only insertion of a tube with a corresponding outer geometry which may be circular, elliptic, rectangular, quadratic or a combination thereof. FIG. 3A shows an upper insert 5 for accommodating tubes with an outer diameter between 10 to 13 mm. FIG. 3B shown an embodiment of an upper insert for tubes with an outer diameter between 13 to 16 mm and FIG. 3C shows an upper insert for hanging tubes into it. Such tubes do not stand on a lower insert 10 or the bottom side of a rack's opening (FIG. 1) but they are attached with their upper end having a collar for instance, to the upper insert 5.

[0048] A lower insert 10 for the adjustment of the height of a rack's slot 3 is shown in FIG. 1. A lower insert 10 can be attached or inserted like a substantially horizontal drawer in different heights in a rack's 1 side walls, so that the available height for a tube of a slot 3 goes from a lower insert 10 to the upper end of the upper insert 5. It is also within the scope of the present invention that a lower insert 10 may have a tilt.

[0049] FIG. 2 shows a reverse side of a rack 1. The front side (FIG. 1) has larger cut-outs or windows 2 along slots 3 in its surface than the reverse side. FIG. 2 shows a position for a RFID label 13. The rack may provide further recesses or areas for codes or label 17 on its front side as well as on its reverse side. Said codes or labels may serve for automated detection by a camera for example.

[0050] A magnet 15 (FIG. 1 and FIG. 2) may also be applied to a rack for its identification or its detection—through a hall sensor for instance—after placing it into a loading area of a device like an automated analyzer or a member of an automated analyzer for loading racks with sample tubes.

[0051] FIG. 4 shows in detail an open lower insert 11 with a third opening 12.

[0052] The embodiment of a rack 1 according to the invention shown in FIG. 5 comprises whole tube upper inserts 6 for very small tubes. A sectional view of such whole tube upper inserts 6 with tube 20 is depicted in FIG. 6. The whole tube upper insert 6 provides enough space to take up a single tube 20 completely that fits tight in the upper opening of the whole tube upper insert 6.

[0053] FIG. 7 shows with respect to the already above-mentioned hanging tubes 22 an embodiment of such a hanging tube 22. In contrast to inserted tube that stand on the lower insert 10 or bottom side of a rack's opening (not shown) the hanging tube 22 is inserted through the upper insert 5 and attaches with its collar 23 to the upper insert 5 where it is stopped and prevented from reaching the openings bottom side. A hanging tube 22 is centered through the lower inserts 11, which have an opening 12 through that the tip 221 of the hanging tube 22 passes. The diameter of opening 12 (not visible) corresponds with the outer diameter of the respective tube so that the hanging tube 22 is centered in slot 3 and its collar 23 attaches to upper insert 5. Again, the diameter of opening 12 (not visible) may be appropriate for different sized hanging tubes 22.

[0054] FIG. 7 shows two open lower inserts 11 arranged in a slot 3 for centering of the hanging tube 22. The exemplary design shown inn FIG. 7 allows for capacitive liquid level determination if the material of the rack 7 is electrically conductive. The use of a plurality of open lower inserts 11 makes the capacitive coupling between a liquid in the hanging tube 22 and ground easier.

[0055] For the automatic handling of the rack 1 in an automated analyzer system, there is a T-shaped groove 25 in the lower part of the rack 1 and special features for the engagement of a toothed conveyer belt 50 (FIG. 8).

[0056] FIG. 9 shows the lower side of a rack 1 with the T-shaped groove 25. Protrusions of a toothed conveyer belt (not shown) may engage for moving rack 1 into frame 60 surrounding the underside of the rack 1. The T-shaped groove is part of frame 60. The shape and size of frame 60 as well as of T-shaped groove 25 may be adapted to specific requirements.

[0057] An advantage of a rack according to the present invention is that a variety of commonly used sample tubes according to CLSI standards can be used in a single rack. The rack allows for manual and automated handling. In addition, the rack is adapted to systems with camera-based readers, code readers or RFID readers or a combination thereof. It is further possible to use a CLLD sensor if the rack is made of electrically conductive material. This functionality may be improved regarding the CLLD by the use of multiple open lower inserts for hanging tubes. A rack according to the invention provides numerous interfaces for automated handling in a single device.

[0058] Alternative approaches may encompass the use of other sensors like photoelectric sensors, etc. instead of using a Hall sensor for detecting a rack in the automated analyzer system or a loading member for racks. A rack according to the invention is not limited to take up five sample tubes. The rack may also have a plurality of rows or even have a circular shape.

[0059] The foregoing description of the preferred embodiment of the invention has been presented for purposes of illustration and description. It is not intended to be exhaustive or to limit the invention to the precise form disclosed, and modifications and variations are possible in light of the above teachings or may be acquired from practice of the invention. The embodiment was chosen and described in order to explain the principles of the invention and its practical application to enable one skilled in the art to utilize the invention in various embodiments as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims appended hereto, and their equivalents. The entirety of each of the aforementioned documents is incorporated by reference herein.

REFERENCE NUMERALS

[0060] 1 rack [0061] 2 cut-out/window [0062] 3 slot [0063] 4 recess [0064] 5 upper insert [0065] 6 whole tube upper insert [0066] 7 second opening [0067] 10 lower insert [0068] 11 open lower insert [0069] 12 third opening [0070] 13 position RFID label [0071] 15 magnet [0072] 17 area for codes or label [0073] 20 tube [0074] 22 hanging tube [0075] 221 tip hanging tube [0076] 23 collar [0077] 25 T-shaped groove [0078] 50 toothed conveyer belt [0079] 60 frame