MAGNESIUM DELIVERY SYSTEM

Abstract

A roll-on product, including magnesium hydroxide; propanediol; glycerin and Glycine soja (soybean), is advantageously used as a deodorant and/or for transdermal magnesium delivery to the human body. Combinations of a magnesium source (especially magnesium hydroxide), with propanediol, and in some formulations with glycerin and Glycine soja (soybean) are advantageous for transdermal delivery of magnesium to the body via a roll-on product, a stick, a spray, a lotion, gel, cream, etc. Magnesium deficiency is addressed via products easily used by an ordinary consumer for dermal application.

Claims

1.-20. (canceled)

21. A lotion, comprising: a magnesium compound selected from the group consisting of magnesium hydroxide; magnesium chloride and magnesium sulfate; and propanediol.

22. The lotion of claim 21, further comprising glycerin and Glycine soja (soybean).

23. (canceled)

Description

DESCRIPTION OF A PREFERRED EMBODIMENT OF THE INVENTION

[0027] For the inventive transdermal magnesium delivery, it will be appreciated that a critical ingredient in any formulation is always a magnesium component. The magnesium component, and indeed each and every component used in the formulation to be used for transdermal magnesium delivery to the body, must be safe for application to human skin. Examples of a magnesium component are, e.g., magnesium hydroxide; magnesium sulfate; magnesium chloride; combinations thereof; etc. Magnesium hydroxide is preferred for use as the magnesium component, such as, e.g., a magnesium hydroxide-containing formulation that is deliverable via a roll-on product; a magnesium hydroxide slurry (such as, e.g., a magnesium hydroxide slurry in which magnesium content to water content is in a range of about 30% Mg:70% H.sub.2O to 70% Mg: 30% H.sub.2O in the slurry, preferably at least 50% Mg (and 50% or less H.sub.2O) in the slurry, more preferably in a range of about 55% Mg:45% H.sub.2O to about 65% Mg:35% H.sub.2O in the slurry, most preferably, at least 60% Mg: 40% (or less) H.sub.2O in the slurry such as, e.g., approximately 60% Mg: 40% H.sub.2O by weight); comprising magnesium hydroxide in a form of, or derived from FloMag® magnesium hydroxide slurry; magnesium hydroxide particles having a median particle size of about 3.0 micron; magnesium hydroxide particles having a size in a range of 1.0-4.0 micron; a magnesium hydroxide slurry characterized by specific surface area of about 10 m.sup.2/g; a magnesium hydroxide slurry characterized by specific surface area in a range of 9-20 m.sup.2/g; etc.

[0028] Flomag® (Flomag H® (commercially available from Martin Marietta) is a magnesium hydroxide slurry that is most preferred to use for an inventive transdermal magnesium delivery formulation. Flomag H® has the following characteristics: On a slurry basis, the Mg(OH), contained is 7.7 lb/gal typically, with 8.0 maximum and 7.0 minimum. On a dry solids basis: the Mg(OH).sub.2 is 98.8 wt % typically, 98.5% minimum, with CaO typically 0.6 wt %, maximum 0.8%; SiO, typically 0.20 wt %, maximum 0.35; Fe, typically 0.10 wt %, 0.21 maximum. Flomag H® has a median particle size of 3.0 micron typically, maximum 4.0, minimum 1.0, a specific surface area of 10 m.sup.2/g typically, 20 maximum and 9 minimum, and is characterized by 3.21 acres/gallon typically, 3.5 maximum and 3.0 minimum.

[0029] An example of a roll-on product is, e.g., a roll-on product comprising a container and a rolling ball that occupies an opening of the container.

[0030] In a case of delivery to the skin via roll-on container, a solution of Flomag® preferably is further combined with one or both of a propanediol component, and a glycerin and Glycine soja (soybean) component.

[0031] A magnesium component (such as, e.g., magnesium hydroxide; magnesium sulfate; magnesium chloride; combinations thereof; etc.) also can be formulated into a spray delivery system, a stick delivery system, a lotion delivery system, a gel delivery system, etc. Combining the magnesium component (such as, e.g., magnesium hydroxide; magnesium sulfate; magnesium chloride; combinations thereof; etc.) with one or both of a propanediol component, and a glycerin and Glycine soja (soybean) component, is preferred for all transdermal delivery systems, such as solutions used in roll-on containers, solutions used in spray delivery containers, solids used as sticks, lotions, gels, etc.

[0032] A preferred example of a glycerin and Glycine soja (soybean) component for use in the invention is a composition comprising glycerin in a range of about 64-82% and Glycine soja in a range of about 18-36% (such as LysoFix® liquid—glycerin and Glycine soja—product #018047 manufactured by Kemin Industries Inc.). The most preferred example of the glycerin and Glycine soja is LysoFix®.

[0033] A preferred example of a propanediol component for use in the invention 1-3 propanediol, such as Zemea® propanediol manufactured by Dupont Tate & Lyle BioProducts.

[0034] The present inventors sometimes use the term “Triangle Ingredients” herein to mean a combination of (1) a magnesium component; (2) a propanediol component and (3) a glycerin and Glycine soja (soybean). Transdermal application of the Triangle Ingredients, variously formulated, is most preferred for delivering magnesium to the body, including use of formulations comprising only the Triangle Ingredients and formulations comprising the Triangle Ingredients with one or more other optional ingredients.

[0035] An amount of magnesium hydroxide or magnesium component in an inventive formulation preferably is in a range of 10-70% by weight, more preferably in a range of 45-55% by weight.

[0036] An amount of propanediol in an inventive formulation preferably is in a range of 10-30% by weight, more preferably in a range of 17.5-22.5% by weight.

[0037] An amount of glycerin (and) Glycine soja (soybean) seed extract in an inventive formulation preferably is in a range of 1-10% by weight, more preferably 3.5-7.5% by weight.

[0038] Examples of a ratio of magnesium hydroxide:glycerin (and) Glycine soja (soybean) seed extract:propanediol in formulations according to the invention are, e.g., in a range of about 9:4:1 to 11:4:1, in a range of about 10:3.5:1 to 10:4.5:1, etc. A most preferred example of a ratio of magnesium hydroxide:glycerin (and) Glycine soja (soybean) seed extract:propanediol in formulation is 10:4:1.

[0039] Examples of ingredients optionally contained in formulations for transdermal delivery of magnesium according to the invention are, e.g., essential oils (such as, e.g., lemon, eucalyptus, lavender, Mentha piperita (peppermint) oil, Rosmarinus offinalis (rosemary) leaf oil, Cymbopogon flexuosus (lemongrass) oil, combinations thereof, etc.); seed extract; plant extract; Matricaria recuita (chamomile); flower extract; heptyl undecylenate; acacia senegal gum; sodium bicarbonate; xanthan gum; combinations thereof; etc.

[0040] Preferably, a solution to be used for transdermal delivery of magnesium according to the invention avoids, or minimizes, usage of aluminum, parabens, phthalates, artificial preservatives, propylene glycol, and synthetic fragrance. Most preferably, a solution to be used for transdermal delivery of magnesium according to the invention contains no aluminum, no parabens, no phthalates, no artificial preservatives, no propylene glycol, no synthetic fragrance.

[0041] Examples of a delivery system for transdermal delivery of magnesium according to the invention are via, e.g., a roll-on, a lotion, a gel solid, a cream (such as, e.g., a shave cream, a blemish cream, etc.), a body wash, a face cleanser, a spray (such as, e.g., a spray deodorant, a body spray, etc.), a powder (such as, e.g., a foot powder, a powder deodorant, etc.), a paste (such as, e.g., a toothpaste, etc.), a mouthwash, etc., with a roll-on, a lotion, and a gel solid being preferred delivery systems.

[0042] The invention may be appreciated with reference to the following examples, without the invention being limited to these examples.

Example 1 (Transdermal Delivery Systems that Administer an Alkaline Magnesium Compound with a pH in the Range of 9 to 11 to the Underarm Skin)

Example 1A

[0043] A method for a transdermal delivery system which administers the alkaline magnesium compound to the underarm skin through one of the following: a roll-on, a stick, a spray, a gel, or a cream. The process of the alkaline magnesium compound reacting with moisture, acids, and salts present on and around the underarm skin causes magnesium ions to be released and available for absorption into the skin.

Example 1B

[0044] A transdermal delivery system wherein the magnesium compound is magnesium hydroxide, magnesium oxide, magnesium sulfate, magnesium chloride, or a combination thereof. The preferred magnesium hydroxide is a hydrolyzed slurry with a ratio of magnesium to water greater than 25%.

Example 1B1

[0045] A preferred formulation includes Flomag®, a hydrolyzed magnesium hydroxide slurry (60% magnesium hydroxide to 40% water) manufactured and sold by Martin Marietta using a patented manufacturing and blending process that results in a chemical reaction to create a highly stable solution with superior surface spread and reactivity.

Example 1B2

[0046] Another preferred formulation includes Flogel®, a low viscosity, magnesium hydroxide gel (29-33% magnesium hydroxide to 67-71% water) manufactured and sold by SPI Pharma.

Example 1C

[0047] Methods according to Examples 1-1B2, wherein the elemental magnesium is at a ratio between 10-60% of total composition weight.

Example 1D

[0048] Transdermal delivery of magnesium according to Examples 1-1A, wherein the absorption of magnesium through the underarm is enhanced using a transdermal delivery system comprising one or more of: (a) active transdermal delivery agent, first means of transport of magnesium through skin; (b) solvent and permeation enhancer, second means for enhancing the permeation of magnesium through the underarm skin; (c) essential oils, third means for enhancing permeability of skin; (d) fourth means for binding the magnesium compound with (a) the active transdermal delivery agent, (b) a solvent and permeation enhancer and (c) essential oils with permeation enhancing properties into a single transdermal delivery system applies to the underarm skin.

Example 1E

[0049] A transdermal delivery system, including as a means for active transdermal delivery one or more of the following vegetable oils: Lysofix®, a soybean seed extract, a sunflower oil, jojoba oil, coconut oil, almond oil, ground nut oil, shea butter oil, corn oil, babassu oil, castor oil, Clark A oil, cotton seed oil, linseed oil, mustard oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, soybean oil, sunflower-seed oil, and wheat germ oil.

Example 1E1

[0050] A preferred formulation includes Lysofix®, a soybean seed extract manufactured and sold by Kemin Industries. Lysofix® has been found by the inventors to be superior to other permeation enhancers which are currently commercially available.

Example 1F

[0051] A transdermal delivery system, including for enhancing the permeation of magnesium through the underarm skin one or more of the following: propanediol, propylene glycol (1,2-propanediol) and butylene glycol (1,3-1,4-butanediol).

Example 1G

[0052] A transdermal delivery system, including for enhancing the permeation of magnesium through the underarm skin one or more of the following essential oils: peppermint, eucalyptus, clove, ylang ylang, wintergreen, tulsi, rose, black cumin, tea tree, lemongrass, grapefruit, orange, lemon, bergamot, tangerine, basil, nutmeg, thyme, geranium, cinnamon, bay leaf, rosemary, camphor, niaouli, and carraway.

Example 1H

[0053] A transdermal delivery system for magnesium delivery, in which is include a water soluble gum of one or more of the following: agar, arabic, arabic senegal, carob, CMC, carrageenans, ghatti, guar, karaya, kadaya, locust bean, tragacanth, xanthan gum.

Example 2 (Early Formulations

Example 2A

Water 10-85%

Mg(OH).SUB.2 .10-60%

Aloe Vera 0-40%

Glycerin 5-15%

Sodium Bicarbonate 0-3%

Xanthan Gum 0-1%

Essential Oils 0-2%

Example 2B

Water 10-85%

MgO 10-60%

Aloe Vera 0-40%

Glycerin 5-15%

Sodium Bicarbonate 0-3%

Xanthan Gum 0-1%

Essential Oils 0-2%

Example 2C

Water 10-85%

Mg(OH).SUB.2 .5-50%

MgO 5-50%

Aloe Vera 0-40%

Glycerin 5-15%

Sodium Bicarbonate 0-3%

Xanthan Gum 0-1%

Essential Oils 0-2%

Example 2D

Water 10-85%

Mg(OH).SUB.2 .1-50%

MgSO.SUB.4 .0-10%

MgO 1-50%

Aloe Vera 0-40%

Glycerin 5-15%

Sodium Bicarbonate 0-3%

Xanthan Gum 0-1%

Essential Oils 0-2%

Example 2E

Flomag® 15-90%

MgSO.SUB.4 .0-10%

Water 0-50%

Aloe Vera 0-40%

Glycerin 5-15%

Sodium Bicarbonate 0-3%

Xanthan Gum 0-1%

Essential Oils 0-2%

Example 2F

Flogel® 30-90%

MgSO.SUB.4 .0-10%

Water 0-50%

Aloe Vera 0-40%

Glycerin 5-15%

Sodium Bicarbonate 0-3%

Xanthan Gum 0-1%

Essential Oils 0-2%

Example 2G

Water 25-75%

MgSO.SUB.4 .20-50%

Mg(OH).SUB.2 .0-20%

Alcohol 0-40%

Witch Hazel 0-45%

Aloe Vera 0-35%

Essential Oils 0-2%

Example 3 (Preferred Formulations

Example 3A

Water 10-90%

Mg(OH).SUB.2 .10-90%

LysoFix® 1-10%

Example 3B

Flomag® 90-99%

LysoFix® 1-10%

Example 3C

Flogel® 90-99%

LysoFix® 1-10%

Example 3D

Water 10-90%

MgO 10-90%

LysoFix® 1-10%

Example 3E

Water 10-90%

MgO 1-50%

Mg(OH), 1-50%

LysoFix® 1-10%

Example 3F

Water 10-90%

Mg(OH), 10-90%

Propanediol 10-70%

LysoFix® 1-10%

Example 3G

Water 10-90%

Mg(OH), 10-90%

Propanediol 10-70%

LysoFix® 1-10%

Essential Oils 0-2%

Example 3H

Water 0-50%

Flomag® 15-90%

Propanediol 10-70%

LysoFix® 1-10%

Essential Oils 0-2%

Example 31

Water 0-50%

Flogel® 30-90%

Propanediol 10-70%

LysoFix® 1-10%

Essential Oils 0-2%

Example 3J

Water 10-90%

Mg(OH), 10-90%

Propanediol 10-70%

LysoFix® 1.5-10%

Arabic Senegal Gum 0-1%

Xanthan Gum 0-1%

Essential Oils 0-2%

Example 3K

Water 10-90%

Mg(OH), 10-90%

Propylene Glycol 10-70%

LysoFix® 1.5-10%

Arabic Senegal Gum 0-1%

Xanthan Gum 0-1%

Essential Oils 0-2%

Example 3L

[0054] water 10-90%
magnesium hydroxide 10-90%
propanediol 10-70%
glycerin & Glycine soja (soybean) seed extract 2-10%
essential oils 0-2%

Example 3M

[0055] water 10-90%
magnesium hydroxide 10-90%
propanediol 10-70%
glyercin & Glycine soja (soybean) seed extract 2-10%
sodium bicarbonate 0-5%
essential oils 0-2%

Example 4 (Most Preferred Formulations

Example 4A

Water 33.5-43.5%

Mg(OH).SUB.2 .25-35%

Propanediol 17.5-22.5%

LysoFix® 3.5-5%

Emollient 2.5-5%

Sodium Bicarbonate 0.5-1%

Gum 0.5-1.5%

Essential Oils 0-2%

Example 4B

Water 15-20%

FloMag® 45-55%

Propanediol 17.5-22.5%

LysoFix® 3.5-5%

Emollient 2.5-5%

Sodium Bicarbonate 0.5-1%

Gums 0.5-1.5%

Essential Oils 0-2%

Example 4C

Water 36-46%

Flogel® 63-73%

Propanediol 17.5-22.5%

LysoFix® 3.5-5%

Emollient 2.5-5%

Sodium Bicarbonate 0.5-1%

Gums 0.5-1.5%

Essential Oils 0-2%

Example 4D

[0056] water 10-90%
magnesium hydroxide 10-90%
propanediol 10-70%
essential oils and plant extracts 0-20%

Example 4E

[0057] water 10-90%
magnesium hydroxide 10-90%
propanediol 10-70%
glycerin & Glycine soja (soybean) seed extract 2-10%
essential oils and plant extracts 0-20%

Example 4F

[0058] water 10-90%
magnesium hydroxide 10-90%
propanediol 10-70%

LysoFix® 0.5-7.5%

[0059] essential oils and plant extracts 0-20%

Example 4G

[0060] water 10-90%
magnesium hydroxide 10-90%
propanediol 10-70%

LysoFix® 0.5-7.5%

[0061] emollient 0-10%
essential oils and plant extracts 0-20%

Example 4H

[0062] water 5-20%

FloMag® 45-55%

Propanediol 17.5-22.5%

LysoFix® 3.5-7.5%

[0063] emollient 0-10%
essential oils 0-15%

Example 41

[0064] water 5-20%

FloMag® 17%-60%

Magnesium Chloride 5-40%

Propanediol 17.5-22.5%

LysoFix® 3.5-7.5%

[0065] emollient 0-10%
essential oils and plant extracts 0-20%

Example 4J

[0066] water 5-20%

FloMag® 17%-60%

Magnesium Sulfate 5-40%

Propanediol 17.5-22.5%

LysoFix® 3.5-7.5%

[0067] emollient 0-10%
essential oils and plant extracts 0-20%

Example 4K

[0068] water 5-20%

FloMag® 17%-30%

Magnesium Chloride 20-35%

Propanediol 17.5-22.5%

LysoFix® 3.5-7.5%

[0069] emollient 0-10%
essential oils and plant extracts 0-15%

Example 4L

[0070] water 5-20%

FloMag® 17%-30%

Magnesium Sulfate 20-35%

Propanediol 17.5-22.5%

LysoFix® 3.5-7.5%

[0071] emollient 0-10%
essential oils and plant extracts 0-15%

Example 4M

FloMag® 50%

Water 0-18%

Propanediol 20%

LysoFix® 5%

LexFeel Natural 5%

[0072] essential oils and plant extracts 1-20%

Example 4N

FloMag® 50%

Water 10-18%

Propanediol 20%

LysoFix® 5%

LexFeel Natural 5%

[0073] essential oils 2-10%

Example 5 (Rosemary-Mint)

[0074] A rosemary-mint magnesium roll-on having no aluminum, no zinc salts, no parabens, no phthalates, no propylene glycol, no synthetic fragrance, no preservatives, having as ingredients:

water
magnesium hydroxide
propanediol
glycerin (and) Glycine soja (soybean) seed extract
Matricaria reculita (chamomile) flower extract
heptyl undecylenate
acacia senegal gum
sodium bicarbonate
Mentha piperita (peppermint) oil
Rosmarinus offinalis (rosemary) leaf oil
xanthan gum
Cymbopogon flexuosus (lemongrass) oil

Example 5A (unscented)

[0075] An unscented magnesium roll-on having no aluminum, no zinc salts, no parabens, no phthalates, no propylene glycol, no synthetic fragrance, no preservatives, having as ingredients:

magnesium hydroxide
water
propanediol
glycerin (and) Glycine soja (soybean)
heptyl undecylenate

Sodium Bicarbonate

[0076] xanthan gum

Acacia Gum

Example 5B (Citrus)

[0077] A citrus magnesium roll-on having no aluminum, no zinc salts, no parabens, no phthalates, no propylene glycol, no synthetic fragrance, no preservatives, having as ingredients:

magnesium hydroxide
water
propanediol
glycerin and Glycine soja (soybean)
heptyl undecylenate

Chamomile Extract

Acacia Gum

Grapefruit

Sodium Bicarbonate

Sweet Orange

[0078] xanthan gum

Lemongrass

Geranium

Example 5C (Lavender)

[0079] A lavender magnesium roll-on having no aluminum, no zinc salts, no parabens, no phthalates, no propylene glycol, no synthetic fragrance, no preservatives, having as ingredients:

magnesium hydroxide
water
propanediol
glycerin and Glycine soja (soybean)
heptyl undecylenate
lavender
acacia gum
sodium bicarbonate
clary sage
xanthan gum
bergamot
lemongrass

Example 6 (Relief of Back Pain)

[0080] A formulation comprising the Triangle Ingredients was used transdermally for relieving back pain. Transdermal application preferably is onto the back where the pain is experienced.

Example 6A (Relief of Muscle Aches)

[0081] A formulation comprising the Triangle Ingredients was used transdermally for relieving muscle aches. Transdermal application is preferably onto the skin near where the muscle aches are experienced.

Example 6B (Relief of Neck Pain)

[0082] In this example, a formulation comprising the Triangle Ingredients is used for relieving neck pain. Transdermal application is preferably onto the skin of the neck.

Example 7

[0083] In this example, a formulation for use in a roll-on product comprises one or more of: seed extract;

Matricaria recuita (chamomile);
flower extract;
heptyl undecylenate;
acacia senegal gum;
sodium bicarbonate;
Metha piperita (peppermint) oil;
Rosmarinus offinalis (rosemary) leaf oil;
xanthan gum; and
Cymbopogon flexuosus (lemongrass) oil.

Example 8

[0084] A formulation for use in a roll-o product comprising (by weight):

water in a range of about 15-20%
magnesium hydroxide in a range of about 45-55%
propanediol in a range of about 17.5-22.5%
glycerin and Glycine soja (soybean) in a range of about 3.5-5%
plant-derived components in a range of about 3.5-9.5%

Example 8A

[0085] The formulation of Example 8, comprising (by weight):

Flomag® 49.5-50%

[0086] propanediol 17.5-22.5%
glycerin and Glycine soja (soybean) 3.5-5%

Example 9 (Unscented Formulation)

[0087] A formulation for a roll-on product consisting of (by weight):

TABLE-US-00001 FloMag  ® 49.5% Water 18.5% Zemea  ® 20.0% Lysofix  ® 5.0% Lexfeel Natural 5.0% Sodium Bicarbonate 1.0% Keltrol 0.3% Acacia Gum 0.7%

Example 10 (Rosemary Mint Formulation)

[0088] A formulation for a roll-on product consisting of (by weight):

TABLE-US-00002 FloMag  ® 50.0% Water 12.7% Zemea  ® 20.0% Lysofix  ® 5.0% Lexfeel Natural 5.0% Chamomile Extract 5.0% Acacia Gum 0.7% Peppermint 0.4% Rosemary 0.3% Sodium Bicarbonate 0.5% Keltrol 0.3% Lemongrass 0.1%

Example 11 (Citrus Formulation)

[0089] A formulation for a roll-on product consisting of (by weight):

TABLE-US-00003 FloMag  ® 50.00% Water 11.50% Zemea  ® 20.00% LysoFix  ® 5.00% LexfeelNatural 5.00% Chamomile Extract 5.00% Acacia Gum 0.70% Grapefruit 0.70% Sodium Bicarbonate 0.50% Sweet Orange 0.50% Keltrol 0.30% Lemongrass 0.50% Geranium 0.40%

Example 12 (Lavender Formulation)

[0090] A formulation for a roll-on product consisting of (by weight):

TABLE-US-00004 FloMag  ® 50.0% Water 16.9% Zemea  ® 20.0% LysoFix  ® 5.0% LexfeelNatural 5.0% Lavender 0.9% Acacia Gum 0.7% Sodium Bicarbonate 0.5% Clary Sage 0.3% Keltrol 0.3% Bergamot 0.2% Lemongrass 0.2%

Example 13

[0091] In this example, for computing an amount of magnesium to be included in a formulation comprising the Triangle Ingredients, an estimate is used that an amount of absorbed magnesium is in a range of about 10-25%, which corresponds to an amount of magnesium applied to the skin but NOT absorbed (such as due to being washed-off) being in a range of about 75-90%.

Example 14 (Magnesium Sulfate)

[0092] In this example, a formulation comprising magnesium sulfate is as follows:

magnesium sulfate 1-10%
water 15-20%

FloMag® 45-55%

Propanediol 17.5-22.5%

LysoFix® 3.5-5%

Example 15 (Formulation Process)

[0093] A preferred formulation process is as follows:

[0094] 1) Mix/shake magnesium hydroxide continuously.

[0095] 2) Mix magnesium hydroxide with water (preferably for about 5 minutes).

[0096] 3) Add glycerin (and) Glycine soja (soybean) seed extract and mix (preferably for about 5 minutes).

[0097] 4) Mix propanediol with acacia and xanthan gums and mix (preferably for about 5 minutes) and add to the magnesium-containing mixture and mix (preferably for about 5 minutes).

[0098] 5) Add sodium bicarbonate, mix (preferably for about 5 minutes)

[0099] 6) Add heptyl undecylenate (and essential oils), mix (preferably for about 10 minutes)

Example 15A

[0100] In this example, steps 1-4 of Example 15 are performed, without performing steps 5-6.

Example 16

[0101] A sprayable solution for transdermal magnesium delivery is prepared, comprising:

water
magnesium sulfate
propanediol
glycerin & Glycine soja (soybean)

Example 16A

[0102] A sprayable solution for transdermal magnesium delivery according to Example 16 is prepared, containing no magnesium hydroxide.

Example 17 (Lotion)

[0103] In this example the Triangle Ingredients are formulated as a lotion comprising 16% magnesium chloride, 16% propanediol.

Example 18 (Lotion)

[0104] In this example, a lotion comprising magnesium chloride and propanediol is formulated without including glycerin and glycine soya extract.

Example 19 (Lotion Formulation)

Water 25-60%

Magnesium Chloride 2%-30%

Propanediol 2.5%-40%

[0105] C13-16 Isoparaffin (and) Heptyl Undecylenate 0%-20%
Glyceryl Stearate (and) Sodium Lactylate 0-15%

Corn Starch Modified 0-5%

Acacia Gum 0-5%

Shea Butter—0-5%

Cocoa Butter—0-5%

[0106] Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol 0-5%

Xanthan Gum 0-5%

Example 19A (Lotion)

49.8% Water

10% Magnesium Chloride

15% Propanediol

[0107] 13% C13-16 Isoparaffin (and) Heptyl Undecylenate
5% Glyceryl Stearate (and) Sodium Lactylate

2% Corn Starch Modified

2% Acacia Gum

1% Shea Butter

1% Cocoa Butter

[0108] 1% Phenylpropanol (and) propanediol(and) Caprylyl Glycol (and) Tocopherol

0.2% Xanthan Gum

Example 19B (Lotion)

Water 25-60%

Magnesium Chloride 2%-30%

Propanediol 2.5%-40%

[0109] C13-16 Isoparaffin (and) Heptyl Undecylenate 0%-20%
Glyceryl Stearate (and) Sodium Lactylate 0-15%

Corn Starch Modified 0-5%

Acacia Gum 0-5%

Shea Butter—0-5%

Cocoa Butter—0-5%

[0110] Phenylpropanol (and) propanediol(and) Caprylyl Glycol (and) Tocopherol 0-5%

Xanthan Gum 0-5%

Glycerin and Glycine Soja (Soybean) Seed Extract

Example 20 (Lotion Formulation)

Water 25-60%

Magnesium Chloride 2%-30%

Propanediol 2.5%-40%

[0111] C13-16 Isoparaffin (and) Heptyl Undecylenate 0-20%
Glyceryl Stearate (and) Sodium Lactylate 0-15%

Glycerin and Glycine Soja (Soybean) Seed Extract 0.5/−7.5%

Corn Starch Modified 0-5%

Acacia Gum 0-5%

Shea Butter 0-5%

Cocoa Butter 0-5%

[0112] Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol 0-5%

Xanthan Gum 0-5%

Essential Oils 0-3%

Natural Fragrance 0-3%

Example 20A (Lotion)

49.8% Water

10% Magnesium Chloride

15% Propanediol

[0113] 10% C13-16 Isoparaffin (and) Heptyl Undecylenate
4.5% Glyceryl Stearate (and) Sodium Lactylate

3.5% Glycerin and Glycine Soja (Soybean) Seed Extract

2% Corn Starch Modified

2% Acacia Gum

1% Shea Butter

1% Cocoa Butter

[0114] 1% Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol

0.2% Xanthan Gum

Example 21 (Lotion Formulation)

Water 25%-60%

Magnesium Hydroxide 2%-60%

Propanediol 2.5%-40%

[0115] C13-16 Isoparaffin (and) Heptyl Undecylenate 0-20%
Glyceryl Stearate (and) Sodium Lactylate 0-15%

Glycerin and Glycine Soja (Soybean) Seed Extract 0.5%-7.5%

Corn Starch Modified 0-5%

Acacia Gum 0-5%

Shea Butter 0-5%

Cocoa Butter 0-5%

[0116] Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol 0-5%

Xanthan Gum 0-5%

Essential Oils 0-3%

Natural Fragrance 0-3%

Example 21A (Lotion)

39.8% Water

20% Magnesium Hydroxide

15% Propanediol

[0117] 10% C13-16 Isoparaffin (and) Heptyl Undecylenate
4.5% Glyceryl Stearate (and) Sodium Lactylate

3.5% Glycerin and Glycine Soja (Soybean) Seed Extract

2% Corn Starch Modified

2% Acacia Gum

1% Shea Butter

1% Cocoa Butter

[0118] 1% Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol

0.2% Xanthan Gum

Example 22 (Lotion Formulation)

Water 25%-60%

Magnesium Hydroxide 2%-60%

Propanediol 2.5%-40%

[0119] C13-16 Isoparaffin (and) Heptyl Undecylenate 0-20%

Magnesium Chloride 0.5-25%

[0120] Glyceryl Stearate (and) Sodium Lactylate 0-15%

Glycerin and Glycine Soja (Soybean) Seed Extract 0.5%-7.5%

Corn Starch Modified 0-5%

Acacia Gum 0-5%

Shea Butter 0-5%

Cocoa Butter 0-5%

[0121] Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol 0-5%

Xanthan Gum 0-5%

Essential Oils 0-3%

Natural Fragrance 0-3%

Example 22A (Lotion)

33.8% Water

18% Magnesium Hydroxide

15% Propanediol

[0122] 10% C13-16 Isoparaffin (and) Heptyl Undecylenate

5% Magnesium Chloride

[0123] 4.5% Glyceryl Stearate (and) Sodium Lactylate

3.5% Glycerin and Glycine Soja (Soybean) Seed Extract

2% Corn Starch Modified

2% Acacia Gum

1% Shea Butter

1% Cocoa Butter

[0124] 1% Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol

0.2% Xanthan Gum

Example 23 (Lotion Formulation)

Water 25%-60%

Magnesium Chloride 2%-30%

Propanediol 2.5%-40%

Capric/caprylic Triglyceride 0-10%

[0125] C13-16 Isoparaffin (and) Heptyl Undecylenate 0-10%
Glyceryl Stearate (and) Sodium Lactylate 0-10%

Corn Starch Modified) 0-5%

Acacia Gum 0-5%

Shea Butter 0-5%

Cocoa Butter 0-5%

[0126] Phenylpropanol (and) propanediol(and) Caprylyl Glycol (and) Tocopherol 0-5%

Xanthan Gum 0-5%

Example 23A (Lotion)

55.8% Water

15% Magnesium Chloride

14% Propanediol

5% Capric/caprylic Triglyceride

[0127] 4% C13-16 Isoparaffin (and) Heptyl Undecylenate
4% Glyceryl Stearate (and) Sodium Lactylate

2% Corn Starch Modified)

2% Acacia Gum

1% Shea Butter

1% Cocoa Butter

[0128] 1% Phenylpropanol (and) propanediol(and) Caprylyl Glycol (and) Tocopherol

0.2% Xanthan Gum

Example 23B (Lotion)

Water 25%-60%

Magnesium Chloride 2%-30%

Propanediol 2.5%-40%

Capric/caprylic Triglyceride 0-10%

[0129] C13-16 Isoparaffin (and) Heptyl Undecylenate 0-10%
Glyceryl Stearate (and) Sodium Lactylate 0-10%

Corn Starch Modified) 0-5%

Acacia Gum 0-5%

Shea Butter 0-5%

Cocoa Butter 0-5%

[0130] Phenylpropanol (and) propanediol(and) Caprylyl Glycol (and) Tocopherol 0-5%

Xanthan Gum 0-5%

Glycerin and Glycine Soja (Soybean) Seed Extract

Example 24 (Lotion Formulation)

Water 25%-60%

Magnesium Chloride 2%-30%

Propanediol 2.5%-40%

Capric/caprylic Triglyceride 0-10%

[0131] C13-16 Isoparaffin (and) Heptyl Undecylenate 0-10%

Glycerin and Glycine Soja (Soybean) Seed Extract 0.5%-7.5%

[0132] Glyceryl Stearate (and) Sodium Lactylate 0-5%

Corn Starch Modified 0-5%

Acacia Gum 0-5%

Shea Butter 0-5%

Cocoa Butter 0-5%

[0133] Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol 0-5%

Xanthan Gum 0-5%

Example 24A (Lotion)

55.8% Water

15% Magnesium Chloride

14% Propanediol

5% Capric/caprylic Triglyceride

[0134] 4% C13-16 Isoparaffin (and) Heptyl Undecylenate

2% Glycerin and Glycine Soja (Soybean) Seed Extract

[0135] 2% Glyceryl Stearate (and) Sodium Lactylate

2% Corn Starch Modified

2% Acacia Gum

1% Shea Butter

1% Cocoa Butter

[0136] 1% Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol

0.2% Xanthan Gum

Example 25 (Lotion Formulation)

Water 25%-60%

Magnesium Hydroxide 2%-60%

Propanediol 2.5%-40%

Capric/caprylic Triglyceride 0-10%

[0137] C13-16 Isoparaffin (and) Heptyl Undecylenate 0-10%

Glycerin and Glycine Soja (Soybean) Seed Extract 0.5-7.5%

[0138] Glyceryl Stearate (and) Sodium Lactylate 0-5%

Corn Starch Modified 0-5%

Acacia Gum 0-5%

Shea Butter 0-5%

Cocoa Butter 0-5%

[0139] Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol 0-5%

Xanthan Gum 0-5%

Example 25A (Lotion)

35.8% Water

20% Magnesium Hydroxide

14% Propanediol

5% Capric/caprylic Triglyceride

[0140] 4% C13-16 Isoparaffin (and) Heptyl Undecylenate

2% Glycerin and Glycine Soja (Soybean) Seed Extract

[0141] 2% Glyceryl Stearate (and) Sodium Lactylate

2% Corn Starch Modified

2% Acacia Gum

1% Shea Butter

1% Cocoa Butter

[0142] 1% Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol

0.2% Xanthan Gum

Example 26 (Lotion Formulation)

Water 25%-60%

Magnesium Hydroxide 2-60%

Propanediol 2.5%-40%

[0143] Magnesium Chloride Oil (50% solids/50% water)

Capric/caprylic Triglyceride 0-10%

[0144] C13-16 Isoparaffin (and) Heptyl Undecylenate 0-10%

Glycerin and Glycine Soja (Soybean) Seed Extract. 5%-7.5%

[0145] Glyceryl Stearate (and) Sodium Lactylate 0-5%

Corn Starch Modified 0-5%

Acacia Gum 0-5%

Shea Butter 0-5%

Cocoa Butter 0-5%

[0146] Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol 0-5%

Xanthan Gum 0-5%

Example 26A (Lotion)

30.8% Water

15% Magnesium Hydroxide

14% Propanediol

[0147] 10% Magnesium Chloride Oil (50% solids/50% water)

5% Capric/caprylic Triglyceride

[0148] 4% C13-16 Isoparaffin (and) Heptyl Undecylenate

2% Glycerin and Glycine Soja (Soybean) Seed Extract

[0149] 2% Glyceryl Stearate (and) Sodium Lactylate

2% Corn Starch Modified

2% Acacia Gum

1% Shea Butter

1% Cocoa Butter

[0150] 1% Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol

0.2% Xanthan Gum

Example 27 (Cream Formulation)

Magnesium Chloride 2%-30%

Water 2%-30%

Cocoa Butter 1-30%

Propanediol 2.5%-40%

[0151] C13-16 Isoparaffin (and) Heptyl Undecylenate 0-20%

Shea Butter 0-15%

[0152] Glyceryl Stearate (and) Sodium Lactylate 0-15%

Corn Starch Modified 0-5%

Acacia Gum 0-5%

Shea Butter 0-5%

Cocoa Butter 0-5%

[0153] Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol 0-5%

Xanthan Gum 0-5%

Example 27A (Cream)

10% Magnesium Chloride

31.3% Water

15% Cocoa Butter

15% Propanediol

[0154] 12% C13-16 Isoparaffin (and) Heptyl Undecylenate

5% Shea Butter

[0155] 4.5% Glyceryl Stearate (and) Sodium Lactylate

2% Corn Starch Modified

2% Acacia Gum

1% Shea Butter

1% Cocoa Butter

[0156] 1% Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol

0.2% Xanthan Gum

Example 28 (Cream Formulation)

Magnesium Chloride 2-30%

Water 2%-30%

Cocoa Butter 1-30%

Propanediol 2.5%-40%

[0157] C13-16 Isoparaffin (and) Heptyl Undecylenate 0-20%

Shea Butter 0-15%

[0158] Glyceryl Stearate (and) Sodium Lactylate 0-15%

Glycerin and Glycine Soja (Soybean) Seed Extract 0.5%-7.5%

Corn Starch Modified 0-5%

Acacia Gum 0-5%

Shea Butter 0-5%

Cocoa Butter 0-5%

[0159] Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol 0-5%

Xanthan Gum 0-5%

Example 28A (Cream)

10% Magnesium Chloride

29.8% Water

15% Cocoa Butter

15% Propanediol

[0160] 10% C13-16 Isoparaffin (and) Heptyl Undecylenate

5% Shea Butter

[0161] 4.5% Glyceryl Stearate (and) Sodium Lactylate

3.5% Glycerin and Glycine Soja (Soybean) Seed Extract

2% Corn Starch Modified

2% Acacia Gum

1% Shea Butter

1% Cocoa Butter

[0162] 1% Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol

0.2% Xanthan Gum

Example 29 (Cream Formulation)

Magnesium Chloride 2-30%

Water 2-30%

Cocoa Butter 1-30%

Propanediol 2.5%-40%

Shea Butter 0-10%

Capric/caprylic Triglyceride 0-10%

[0163] C13-16 Isoparaffin (and) Heptyl Undecylenate 0-10%
Glyceryl Stearate (and) Sodium Lactylate 0-5%

Corn Starch Modified 0-5%

Acacia Gum 0-5%

[0164] Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol 0-5%

Xanthan Gum 0-5%

Example 29A (Cream)

15% Magnesium Chloride

36.8% Water

15% Cocoa Butter

14% Propanediol

5% Shea Butter

5% Capric/caprylic Triglyceride

[0165] 4% C13-16 Isoparaffin (and) Heptyl Undecylenate
2% Glyceryl Stearate (and) Sodium Lactylate

2% Corn Starch Modified

2% Acacia Gum

[0166] 1% Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol

0.2% Xanthan Gum

Example 30 (Cream Formulation)

Magnesium Chloride Oil 2-30%

Water 2-30%

Cocoa Butter 1-30%

Propanediol 2.5%-40%

Shea Butter 0-15%

Capric/caprylic Triglyceride 0-10%

[0167] C13-16 Isoparaffin (and) Heptyl Undecylenate 0-10%

Glycerin and Glycine Soja (Soybean) Seed Extract. 5%-7.5%

[0168] Glyceryl Stearate (and) Sodium Lactylate 0-5%

Corn Starch Modified 0-5%

Acacia Gum 0-5%

[0169] Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol 0-5%

Xanthan Gum 0-5%

Example 30A (Cream)

15% Magnesium Chloride Oil

39.8% Water

15% Cocoa Butter

14% Propanediol

5% Shea Butter

5% Capric/caprylic Triglyceride

[0170] 4% C13-16 Isoparaffin (and) Heptyl Undecylenate

2% Glycerin and Glycine Soja (Soybean) Seed Extract

[0171] 2% Glyceryl Stearate (and) Sodium Lactylate

2% Corn Starch Modified

2% Acacia Gum

[0172] 1% Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol

0.2% Xanthan Gum

Example 31 (Cream Formulation)

Water 2-30%

Magnesium Hydroxide 2-60%

Cocoa Butter 0-30%

Magnesium Chloride 0-15%

Shea Butter 0-15%

Propanediol 2.5%-40%

Capric/caprylic Triglyceride 0-10%

[0173] C13-16 Isoparaffin (and) Heptyl Undecylenate 0-10%

Glycerin and Glycine Soja (Soybean) Seed Extract 0.5%-7.5%

[0174] Glyceryl Stearate (and) Sodium Lactylate 0-5%

Corn Starch Modified 0-5%

Acacia Gum 0-5%

Shea Butter 0-5%

Cocoa Butter 0-5%

[0175] Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol 0-5%

Xanthan Gum 0-5%

Example 31A (Cream)

20.8% Water

15% Magnesium Hydroxide

15% Cocoa Butter

5% Magnesium Chloride

5% Shea Butter

14% Propanediol

5% Capric/caprylic Triglyceride

[0176] 4% C13-16 Isoparaffin (and) Heptyl Undecylenate

2% Glycerin and Glycine Soja (Soybean) Seed Extract

[0177] 2% Glyceryl Stearate (and) Sodium Lactylate

2% Corn Starch Modified

2% Acacia Gum

1% Shea Butter

1% Cocoa Butter

[0178] 1% Phenylpropanol (and) propanediol (and) Caprylyl Glycol (and) Tocopherol

0.2% Xanthan Gum

Example 32

[0179] A gel deodorant has been formulated, comprising magnesium chloride, propanediol, silica and zinc lactate.

Example 32A

[0180] A gel deodorant has been formulated, comprising:

magnesium chloride 16%
propanediol 15%
silica 6.5%
zinc lactate 2%

Example 33 (Formulation of Gel Deodorant)

Water: 10-70%

Magnesium Chloride. 5%-40%

Propanediol: 2.5-50%

Silica: 2-20%

Zinc Lactate: 0-8%

Caprylyl Glycol: 0-5%

Phenylpropanol: 0%-5%

Tocopherol: 0%-5%

Ethylhexylglycerin: 0%-5%

Essential Oils 0-4%

Natural Fragrance 0-4%

Example 33A (Gel Deodorant)

54% Water

16% Magnesium Chloride

16% Propanediol

6.5% Silica

2% Zinc Lactate

1% Caprylyl Glycol

0.5% Phenylpropanol

0.5% Tocopherol

0.5% Ethylhexylglycerin

3% Natural Fragrance

Example 33B (Gel Deodorant)

Water: 10-70%

Magnesium Chloride 0.5%-40%

Propanediol: 2.5-50%

Silica: 2-20%

Zinc Lactate: 0-8%

Caprylyl Glycol: 0-5%

Phenylpropanol: 0%-5%

Tocopherol: 0%-5%

Ethylhexylglycerin: 0%-5%

Glycerin and Glycine Soja (Soybean) Seed Extract

Essential Oils: 0-4%

Natural Fragrance: 0-4%

Example 34 (Formulation of Gel)

Water 0-50%

Magnesium Chloride 0.5-40%

Propanediol 20-60%

Sodium Hydroxide 7-10%

Stearic Acid 5-10%

Polyglyceryl-10 Caprylate/Caprate 0-8%

Fragrance 0-4%

Example 34A (Gel)

15% Water

15% Magnesium Chloride

45% Propanediol

9.5% Sodium Hydroxide

6% Stearic Acid

8% Polyglyceryl-10 Caprylate/Caprate

1.5% Fragrance

Example 35 (Formulation of Gel)

Water 0-10%

Magnesium Chloride 0.5-40%

Propanediol 20-70%

Sodium Hydroxide 7-10%

Stearic Acid 5-10%

[0181] Glycerin & glycine (soya) extract 0-5%

Polyglyceryl-10 Caprylate/Caprate 0-8%

Fragrance 0-4%

Example 35A (Gel)

6% Water

10% Magnesium Chloride

60% Propanediol

9.5% Sodium Hydroxide

6% Stearic Acid

[0182] 2% Glycerin & glycine (soya) extract

6% Polyglyceryl-10 Caprylate/Caprate

0.5% Fragrance

Example 36 (Formulation of Gel)

Magnesium Chloride. 55-40%

Propanediol 20-70%

[0183] glycerin 10-19.5%
glycerin and glycine (soya) extract 0.5-10%

Sodium Hydroxide 8-12%

Stearic Acid 5-7.5%

Ethylhexylglycerin 0.1-2%

Fragrance 0-4%

Example 36A (Gel)

15% Magnesium Chloride

45% Propanediol

[0184] 15% glycerin
5% glycerin and glycine (soya) extract

9.5% Sodium Hydroxide

6% Stearic Acid

0.75% Ethylhexylglycerin

0.75% Fragrance

Example 37 (Formulation of Gel)

Water 0-10%

[0185] Magnesium Hydroxide slurry 2-50%

Propanediol 30-65%

Sodium Hydroxide 8-12%

Stearic Acid 5-7.5%

Polyglyceryl-10 Caprylate/Caprate 0-8%

Sodium Bicarbonate 0-2%

Fragrance 0-4%

Example 37A (gel)

[0186] 18% Magnesium Hydroxide slurry

58% Propanediol

9.5% Sodium Hydroxide

6% Stearic Acid

8% Polyglyceryl-10 Caprylate/Caprate

0.5% Fragrance

Example 38 (Formulation of Gel)

Water 0-20%

Magnesium Chloride 0.5-20%

Magnesium Hydroxide. 5-40%

Propanediol 30-60%

[0187] glycerin 1-20%
glycerin and glycine (soya) extract 1-10%

Polyglyceryl-10 Caprylate/Caprate 0-8%

Sodium Hydroxide 8-12%

Stearic Acid 5-7.5%

Ethylhexylglycerin 0.1-2

Fragrance 0-4%

Example 38A (Gel)

7.25% Water

10% Magnesium Chloride

10% Magnesium Hydroxide

45% Propanediol

[0188] 10% glycerin
10% glycerin and glycine (soya) extract

9.5% Sodium Hydroxide

6% Stearic Acid

0.75% Ethylhexylglycerin

0.75% Fragrance

Example 39 (Roll-On)

[0189] A solution for use in a roll-on has been formulated, comprising:

magnesium hydroxide 42%
magnesium chloride 5%
propanediol 20%
glycerin & glycine soya oil 5%

Example 40 (Roll-On)

[0190] When using magnesium hydroxide to formulate a solution for a roll-on product, a preferred magnesium hydroxide is a slurry that has a magnesium to water ratio of 60/40. FloMag® is the most preferred magnesium hydroxide slurry.

[0191] Ratio of total magnesium to total water in a formulation varies based on additional amount of water (if any) in the formulation from contribution other than magnesium hydroxide, as well as additional amount of magnesium (if any) in the formulation from contribution other than magnesium hydroxide (e.g., when magnesium chloride is included in a formulation along with a 60/40 magnesium hydroxide slurry).

Example 41 (Roll-on Formulations/Gout Treatment)

Water 2-60%

Magnesium Hydroxide Slurry 20-80%

Propanediol 10-50%

[0192] Glycerin (and) Glycine Soja (Soybean) Seed Extract 3.5-10%

Heptyl Undecylenate 0-10%

Acacia Gum 0.1-2%

Sodium Bicarbonate 0-5%

Xanthan Gum 0.1-1%

Menthol 0-2%

[0193] Essential Oils (camphor, eucalyptus, rosemary, lemongrass) 0-5%
Natural Fragrance(s) (limonene, citral, citronellol, geraniol) 0-5%

Example 41A (Roll-on/Gout Treatment)

13.5% Water

50% Magnesium Hydroxide Slurry

20% Propanediol

[0194] 5% Glycerin (and) Glycine Soja (Soybean) Seed Extract

5% Heptyl Undecylenate

0.7% Acacia Gum

1% Sodium Bicarbonate

0.3% Xanthan Gum

1% Menthol

[0195] 2.5% Essential Oils (camphor, eucalyptus, rosemary, lemongrass)
1% Natural Fragrance(s) (limonene, citral, citronellol, geraniol)

Example 42 (Shave Cream)

Water 1-70%

Magnesium Hydroxide 2-60%

Propanediol 1-50%

Glycerin and Glycine Soja (Soybean) Seed Extract 0.5%-15%

Aloe Barbadensis (Aloe Vera) Leaf Juice 0-25%

Shea Butter 0-20%

Coconut Oil 0-20%

Olive Oil 0-10%

Jojoba Oil 0-10%

Rosemary Extract 0-5%

Guar Gum Extract 0-5%

Example 43 (Body Wash)

Water 1-80%

Magnesium Chloride 2-40%

Glycerin and Glycine Soja (Soybean) Seed Extract 0.5%-15%

Propanediol 1-50%

Aloe Barbadensis (Aloe Vera) Leaf Juice 0-25%

Shea Butter 0-20%

Coconut Oil 0-15%

Olive Oil 0-15%

Jojoba Oil—0-10%

Rosemary Extract 0-5%

Guar Gum Extract 0-5%

Example 44 (Body Wash)

Water 1-80%

Magnesium Hydroxide 2-40%

Glycerin and Glycine Soja (Soybean) Seed Extract. 5%-15%

Propanediol 1-50%

Aloe Barbadensis (Aloe Vera) Leaf Juice 0-25%

Shea Butter 0-20%

Coconut Oil 0-15%

Olive Oil 0-15%

Jojoba Oil—0-10%

Rosemary Extract 0-5%

Guar Gum Extract 0-5%

Example 45 (Body Wash)

Water 1-80%

Magnesium Sulfate 2-40%

Glycerin and Glycine Soja (Soybean) Seed Extract 0.5%-15%

Propanediol 1-50%

Aloe Barbadensis (Aloe Vera) Leaf Juice 0-25%

Shea Butter 0-20%

Coconut Oil 0-15%

Olive Oil 0-15%

Jojoba Oil—0-10%

Rosemary Extract 0-5%

Guar Gum Extract 0-5%

Example 46 (Cleanser)

Water 1-80%

Magnesium Chloride 2-40%

Glycerin and Glycine Soja (Soybean) Seed Extract 0.5-15%

Propanediol 1-50%

Aloe Barbadensis (Aloe Vera) Leaf Juice 0-25%

Shea Butter 0-20%

Coconut Oil 0-15%

Olive Oil 0-15%

Jojoba Oil 0-10%

Rosemary Extract 0-5%

Guar Gum Extract 0-5%

Xanthan Gum 0-5%

Caprylic Triglyceride 0-15%

Cetearyl Glucoside 0-15%

Cetearyl Alcohol 0-15%

Cetearyl Olivate 0-10%

Denatured Alcohol 0-15%

Sodium Hyaluronate 0-10%

Sodium Benzoate 0-10%

Example 47 (Cleanser)

Water 1-80%

Magnesium Hydroxide 2-40%

Glycerin and Glycine Soja (Soybean) Seed Extract 0.5-15%

Propanediol 1-50%

Aloe Barbadensis (Aloe Vera) Leaf Juice 0-25%

Shea Butter 0-20%

Coconut Oil 0-15%

Olive Oil 0-15%

Jojoba Oil 0-10%

Rosemary Extract 0-5%

Guar Gum Extract 0-5%

Xanthan Gum 0-5%

Caprylic Triglyceride 0-15%

Cetearyl Glucoside 0-15%

Cetearyl Alcohol 0-15%

Cetearyl Olivate 0-10%

Denatured Alcohol 0-15%

Sodium Hyaluronate 0-10%

Sodium Benzoate 0-10%

Example 48 (Blemish Cream)

Water 1-80%

Magnesium Hydroxide 1-80%

Magnesium Chloride 0-15%

Magnesium Sulfate 0-15%

Propanediol 1-50%

Glycerin and Glycine Soja (Soybean) Seed Extract. 5-7.5%

Xanthan Gum 0-5%

Guar Gum Extract 0-5%

Citric Acid 0-5%

Tea Tree Leaf Oil 0-5%

Caprylic Triglyceride 0-5%

Cetearyl Olivate 0-5%

Citric Acid 0-5%

Rosemary Leaf Oil 0-5%

Lavender Oil 0-5%

Sorbitan Olivate 0-5%

Jojoba Oil 0-5%

Menthol 0-5%

Example 49 (Spray Deodorant)

Water 1-80%

Magnesium Chloride 1-30%

Propanediol 1-50%

Polyglyceryl-10 Caprylate/Caprate 0-10%

Natural Fragrance 0-5%

Example 50 (Spray Deodorant)

Water 1-80%

Magnesium Chloride 1-30%

Propanediol 1-50%

Glycerin and Glycine Soja Seed Extract 0.5-7.5%

Polyglyceryl-10 Caprylate/Caprate 0-10%

Natural Fragrance 0-5%

Example 51 (Body Spray)

Water 1-80%

[0196] Magnesium chloride (10%) 1-30%

Propanediol 1-50%

Ethanol (8%) 0-15%

[0197] Polysorbate 80 (bio-based version available soon) 0-10%

Polyglyceryl-10 Caprylate/caprate 0-10%

[0198] Essential oils 0-7.5%
Soyethyl morpholinium ethosulfate 0-5%

Example 52 (Body Spray)

Water 1-80%

[0199] Magnesium chloride 1-30%

Propanediol 1-50%

Glycerin and Glycine Soja Seed Extract 0.5-7.5%

Ethanol (8%) 0-15%

[0200] Polysorbate 80 (bio-based version available soon) 0-10%

Polyglyceryl-10 Caprylate/caprate 0-10%

[0201] Essential oils 0-7.5%
Soyethyl morpholinium ethosulfate 0-5%

Example 53 (Body Spray)

Water 1-80%

[0202] Magnesium sulfate 1-30%

Propanediol 1-50%

Polysorbate 80 0-40%

Ethanol 0-15%

Polyglyceryl-10 Caprylate/caprate 0-10%

[0203] Essential oils 0-7%
Myristamidopropyl PG-dimonium chloride phosphate 0-5%

Example 54 (Body Spray)

Water 1-80%

[0204] Magnesium sulfate 1-30%

Propanediol 1-50%

Glycerin and Glycine Soja Seed Extract 0.5-7.5%

Polysorbate 80 0-40%

Ethanol 0-15%

Polyglyceryl-10 Caprylate/caprate 0-10%

[0205] Essential oils 0-7%
Myristamidopropyl PG-dimonium chloride phosphate 0-5%

Example 55 (Toothpaste)

Water 2%-80%

[0206] Glycerin (and) Glycine Soja (Soybean) Seed Extract 0.5%-10%
Magnesium Hydroxide (60% solids/40% water) 0.5%-40%

Propanediol (Zea Mays) 0.5%-20%

Sorbitol—0-10%

[0207] Aloe barbadensis leaf juice (Organic)—0-10%

Xylitol 0-5%

Natural Flavor 0-10%

Benzoic Acid (Natural) 0-10%

Phosphoric Acid 0-5%

Disodium Phosphate 0-5%

Sodium Fluoride 0-5%

Example 56 (Toothpaste)

Water 2%-80%

[0208] Glycerin (and) Glycine Soja (Soybean) Seed Extract 0.5%-10%

Magnesium Chloride 0.5%-40%

Propanediol (Zea Mays) 0.5%-20%

Sorbitol—0-10%

[0209] Aloe barbadensis leaf juice (Organic)—0-10%

Xylitol 0-5%

Natural Flavor 0-10%

Benzoic Acid (Natural) 0-10%

Phosphoric Acid 0-5%

Disodium Phosphate 0-5%

Sodium Fluoride 0-5%

Example 57 (Foot Powder)

62.5% Corn Starch Modified

20% Avena Sativa Kernel Flour

5% Magnesium Oxide

5% Zinc Oxide

5% Sodium Bicarbonate

3% Kaolin

0.3% Eucalytus Oil

0.2% Peppermint Oil

Example 58 (Foot Powder)

62.5% Corn Starch Modified

20% Avena Sativa Kernel Flour

10% Magnesium Oxide

5% Sodium Bicarbonate

3% Kaolin

0.3% Eucalytus Oil

0.2% Peppermint Oil

Example 59

[0210] The following roll-on formulations are useable as body deodorant and/or against muscle pain.

Example 59A

[0211] Magnesium hydroxide 45-55%

Water 10-20%

Propanediol 15-25%

[0212] Glycerin (and) Glycine soja (soybean) seed extract 1-10%

Emollient 3-10%

Menthol 5-15%

Camphor 3-10%

Eucalyptus 3-10%

Witch Hazel 2-10%

Example 59B

[0213] Magnesium hydroxide 35-45%

Water 10-20%

Propanediol 15-25%

[0214] Glycerin (and) Glycine soja (soybean) seed extract 1-10%

Emollient 3-10%

Menthol 5-15%

Camphor 3-10%

Eucalyptus 3-10%

Witch Hazel 2-10%

Aloe Vera 5-15%

Arnica 2-6%

Example 60 (Total Magnesium)

[0215] “Total Magnesium” refers to magnesium, by weight, contributed by all magnesium-containing ingredients in a formulation. To illustrate, in some formulations, the only magnesium-containing ingredient is a MgOH slurry. In other formulations, the only magnesium-containing ingredient is MgCl. In other formulations, the magnesium-containing ingredients include both a MgOH slurry and MgCl. In yet other formulations, another magnesium-containing ingredient, or another combination of two or more magnesium-containing ingredients, is used.

Example 60A (Roll-Ons)

[0216] In this example, total magnesium is in a range of 0.1%-40% by weight of the roll-on solution.

Example 60B (Roll-Ons)

[0217] In this example, total magnesium is in a range of 25-30% by weight of the roll-on solution.

Example 60B (Roll-Ons)

[0218] In this example, total magnesium is in a range of 28-28.5% by weight of the roll-on solution.

Example 60C (Gels)

[0219] In this example, total magnesium is in a range of 0.1%-40% by weight of the gel.

Example 60D (Gels)

[0220] In this example, total magnesium is in a range of 10-30% by weight of the gel.

Example 60E (Gels)

[0221] In this example, total magnesium is about 16% by weight of the gel.

Example 60F (Lotions and Creams)

[0222] In this example, total magnesium is in a range of 0.1-60% by weight of the lotion or cream.

Example 60G (Lotions and Creams)

[0223] In this example, total magnesium is in a range of 5-25% by weight of the lotion or cream.

Example 60H (Lotion)

[0224] In this example, total magnesium is about 10% by weight of the lotion.

Example 60I (Lotion)

[0225] In this example, total magnesium is about 15% by weight of the lotion.

Example 60J (Body Wash)

[0226] In this example, total magnesium is in a range of 2-40% by weight of the body wash solution.

Example 60K (Body Sprays and Deodorant Sprays)

[0227] In this example, total magnesium is in a range of about 1-30% by weight of the spray solution.

Example 60L (Toothpaste)

[0228] In this example, total magnesium is in a range of about 0.5-40% by weight of the toothpaste.

Example 60M (Foot Powder)

[0229] In this example, total magnesium is in a range of about 2-40% by weight of the foot powder.

[0230] The descriptions of various embodiments of the present invention have been presented for purposes of illustrations, but are not intended to be exhaustive. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments.