Composition for Treating Diarrhea

Abstract

Disclosed in the present invention is a composition for treating diarrhea, comprising the following components calculated by weight ratio: Colocasia esculenta and antidiarrheal foods. The composition of the present invention has low cost, available raw materials, is safe and non-toxic, and is suitable for industrial production. The antidiarrheal effect of the product is remarkable. The rehabilitation time for the common diarrhea is 24-48 hours, and for the diarrhea caused by rotavirus is 48-72 hours, and the rehabilitation time is shortened by 2.5 days on average. The effective rate for persistent diarrhea within 5 days is 90.16%. For diarrhea of infants with milk protein allergy during the addition of supplementary feeding, six to eight kinds of foods can be added in one month, and thus the composition is especially suitable for infants and young children.

Claims

1. A composition for treating diarrhea, comprising taro and antidiarrheal food; the antidiarrheal food includes vegetables, meats, fruits or nuts, beans or cereals; the vegetables include one or more selected from the group consisting of carrot, broccoli, cauliflower, bok choy, purple sweet potato, Chinese yam, lotus root and lotus seed; the meats include one or more selected from the group consisting of beef, pork liver and pork; the fruits or nuts include one or more selected from the group consisting of cooked apple, chestnuts and jujube; the beans include small red bean and/or azuki bean; the cereals include one or more selected from the group consisting of rice, glutinous rice and sorghum rice; and the antidiarrheal food can be one or more combinations in any ratio by weight.

2. The composition according to claim 1, characterized in that the ratio of taro by weight is 10-90%, and the ratio of antidiarrheal food by weight is 10-90%; preferably, 10-85% taro and 15-90% antidiarrheal food; more preferably, 15-80% taro and 20-85% antidiarrheal food; further preferably, 25-75% taro and 25-75% antidiarrheal food; further preferably, 30-70% taro and 30-70% antidiarrheal food; further preferably, 35-65% taro and 35-65% antidiarrheal food; further preferably, 40-60% taro and 40-60% antidiarrheal food; more preferably, 50% taro and 50% antidiarrheal food; within the above-mentioned ratio ranges, the ratio of taro and antidiarrheal food by weight may be 90% taro and 10% antidiarrheal food; 10% taro and 90% antidiarrheal food; 85% taro and 15% antidiarrheal food; 80% taro and 20% antidiarrheal food; 75% taro and 25% antidiarrheal food; 70% taro and 30% antidiarrheal food; 65% taro and 35% antidiarrheal food; 60% taro and 40% antidiarrheal food; 55% taro and 45% antidiarrheal food; 45% taro and 55% antidiarrheal food; 40% taro and 60% antidiarrheal food; 35% taro and 65% antidiarrheal food; 30% taro and 70% antidiarrheal food; 25% taro and 75% antidiarrheal food; 20% taro and 80% antidiarrheal food; or 15% taro and 85% antidiarrheal food.

3. The composition according to claim 1 or 2, characterized in that the components comprises: the vegetables include one or more selected from the group consisting of carrot, broccoli, cauliflower, purple sweet potato, lotus root and lotus seed; fruits or nuts include one or more selected from the group consisting of cooked apple and jujube; more preferably, the vegetables include one or more selected from the group consisting of carrot, broccoli, cauliflower and purple sweet potato; further preferably, the vegetables include one or two selected from the group consisting of carrot and purple sweet potato; furthermore preferably, the vegetable is carrot.

4. The composition according to claim 1 or 2, characterized in that the components comprises: the antidiarrheal food includes one or more selected from the group consisting of carrot, purple sweet potato, beef, chestnuts, jujube, small red bean, azuki bean, rice, glutinous rice and sorghum rice; preferably, the antidiarrheal food includes one or more selected from the group consisting of carrot, purple sweet potato, jujube, small red bean, azuki bean, rice, glutinous rice and sorghum rice; further preferably, the antidiarrheal food includes one or more selected from the group consisting of carrot, purple sweet potato, jujube, rice, glutinous rice and sorghum rice; more preferably, the antidiarrheal food includes one or more selected from the group consisting of carrot, jujube, rice, glutinous rice and sorghum rice; and still further preferably, the antidiarrheal food includes one or more selected from the group consisting of carrot, rice and glutinous rice.

5. The composition according to claim 1 or 2, characterized in that the ratios of the components by weight are as follows: 10-70% vegetables, 5-30% meats, 5-60% fruits or nuts, 10-60% beans, and 10-70% cereals; preferably, 20-40% vegetables, 10-20% meats, 10-40% fruits or nuts, 10-40% beans, and 20-40% cereals; more preferably, 30% vegetables, 10% meats, 10% fruits or nuts, 20% beans, and 30% cereals; preferably, within the above-mentioned ratio ranges, the ratio of the antidiarrheal food by weight may be 60% carrot, 10% beef, 5% jujube, 10% small red bean, and 15% rice; 30% broccoli, 15% pork, 25% steamed apple, 15% azuki bean, and 15% glutinous rice; 25% carrot and purple sweet potato, 10% beef, 20% jujube, 18% small red bean and azuki bean, and 27% rice and glutinous rice; 15% lotus seed, 20% pork liver, 15% jujube and cooked apple, 20% azuki bean, and 30% sorghum; or 30% carrot, 10% beef, 10% jujube, 20% small red bean, and 30% rice.

6. The composition according to claim 1 or 2, characterized in that the ratios of the components by weight are as follows: 10-75% vegetables, 5-60% fruits or nuts, 10-60% beans, and 10-75% cereals; preferably, 10-60% vegetables, 10-40% fruits or nuts, 20-50% beans, and 10-60% cereals; more preferably, 20-40% vegetables, 20-40% fruits or nuts, 20-40% beans, and 20-40% cereals; further preferably, 30% vegetables, 20% fruits or nuts, 20% beans, and 30% cereals; within the above-mentioned ratio ranges, the ratio of antidiarrheal food by weight may be 40% cauliflower and purple sweet potato, 15% jujube, 25% small red bean, and 20% rice and glutinous rice; 30% carrot, 20% steamed apple, 20% azuki bean, and 30% glutinous rice; 25% carrot and purple sweet potato, 20% jujube, 25% small red bean and azuki bean, and 30% sorghum rice; 20% lotus root, 20% jujube and cooked apple, 30% azuki bean, and 30% glutinous rice; or 30% carrot, 20% jujube, 20% red bean, and 30% rice.

7. The composition according claim 1 or 2, characterized in that the ratio of antidiarrheal food by weight may be 10-90% vegetables and 10-90% cereals; preferably, 25-75% vegetables and 25-75% cereals; more preferably, 30-70% vegetables and 30-70% cereals; further preferably, 40-60% vegetables and 40-60% cereals; furthermore preferably, 50% vegetables and 50% cereals; within the above-mentioned ratio ranges, the ratio of the antidiarrheal food by weight may be 80% carrot and 20% rice; 90% broccoli and carrot, and 10% glutinous rice; 25% purple sweet potato, and 75% rice and glutinous rice; 40% lotus seed, and 60% sorghum rice and glutinous rice; 45% cauliflower and broccoli, and 55% rice; 50% carrot and purple sweet potato, and 50% rice and glutinous rice.

8. The composition according to claim 1 or 2, characterized in that the trace elements with following contents can also be added to the composition: preferably, the energy per 100 g of the composition is ≥1250 kJ; the nutrients per 100 kJ include: protein ≥0.33 g, fat ≤0.8 g, vitamin A 14-43 μgRE, vitamin D 0.25-0.75 μg, vitamin B1≥12.5 μg, calcium ≥12 mg, iron 0.25-0.5 mg, zinc ≥0.17-0.46 mg, and sodium ≤24 mg; more preferably, the following contents of vitamins and minerals can also be added to the composition: vitamin E 0.08-1.2 mg, vitamin B2≥13 μg, vitamin B6≥8.4 μg, vitamin B12≥0.02 μg, niacin ≥83.7 μg, folic acid ≥1.2 μg, pantothenic acid ≥50.4 μg, vitamin C≥1.4 mg, biotin ≥0.17 μg, phosphorus 8.4-30 mg, iodine 1.4-8.8 μg, and potassium 13-66 mg; more preferably, in order to further meet the need of growth and development of infants under 1 year old during diarrhea, the nutrients and contents contained per 100 kJ in the composition of the present invention comprise: protein 0.45-0.7 g, fat 1.05-1.4 g, carbohydrate 2.2-3.3 g, vitamin A 14-43 μgRE, vitamin D 0.25-0.6 μg, vitamin E 0.12-1.2 mg, vitamin K1 1.0-6.5 μg, vitamin B1 14-72 μg, vitamin B2 19-119 μg, vitamin B6 8.5-45 μg, vitamin B12 0.02-0.36 μg, niacin 70-360 μg, folic acid 2.5-12 μg, pantothenic acid 96-478 μg, vitamin C 2.5-17 mg, biotin 0.4-2.4 μg, sodium 5-14 mg, potassium 14-43 mg, copper 8.5-29 μg, magnesium 1.2-3.6 mg, iron 0.1-0.36 mg, zinc 0.12-0.36 mg, manganese 1.2-24 μg, calcium 12-35 mg, phosphorus 6-24 mg, the ratio of calcium to phosphorus 1:1-2:1, iodine 2.5-14 μg, chlorine 12-38 mg, and selenium 0.48-1.9 μg; preferably, the following content of trace elements can also be added to the composition: chromium 0.4-2.4 μg, molybdenum 0.4-2.4 μg, choline 1.7-12 mg, inositol 1-9.5 mg, taurine ≤3 mg, L-carnitine≥0.3 mg, docosahexaenoic acid (% of total fatty acids) ≤0.5, and eicosatetraenoic acid (% of total fatty acids) ≤1; further preferably, in order to further meet the need of growth and development of children over 1 year old during diarrhea, the nutrients and content contained per 100 kJ in the composition of the present invention include: vitamin A 17.9-58.3 μgRE, vitamin D 0.25-0.75 μg, vitamin E ≥0.15 mg, vitamin K1≥1 μg, vitamin B1≥0.01 mg, vitamin B2≥0.01 mg, vitamin B6≥0.01 mg, vitamin B12≥0.04 μg, niacin ≥0.11 mg, folic acid ≥1 μg, pantothenic acid ≥0.07 mg, vitamin C ≥1.8 mg, biotin ≥0.4 μg, sodium 5-20 mg, potassium 18-69 mg, copper 7-35 μg, magnesium ≥1.4 mg, iron 0.25-0.5 mg, zinc 0.1-0.4 mg, manganese 0.3-24 μg, calcium ≥17 mg, phosphorus 8.3-46.2 mg, the ratio of calcium to phosphorus 1:1-2:1, iodine ≥1.4 μg, chlorine ≤52 mg, and selenium 0.5-2.9 μg; further preferably, the following contents of trace elements can also be added to the composition: chromium 0.4-5.7 μg, molybdenum 1.2-5.7 μg, fluorine ≤0.05 mg, choline 1.7-19.1 mg, inositol 1-9.5 mg, taurine ≤3.1 mg, L-carnitine ≥0.3 mg, docosahexaenoic acid (% of total fatty acids) ≤0.5, eicosatetraenoic acid (% of total fatty acids) ≤1, nucleotides ≥0.5 mg, and dietary fiber ≤0.7 g.

9. Method for the preparation of a composition for treating diarrhea, comprising taro and antidiarrheal food; wherein the antidiarrheal food includes vegetables, meats, fruits or nuts, beans or cereals; wherein the vegetables include one or more selected from the group consisting of carrot, broccoli, cauliflower, bok choy, purple sweet potato, Chinese yam, lotus root and lotus seed; wherein the meats include one or more selected from the group consisting of beef, pork liver and pork; wherein the fruits or nuts include one or more selected from the group consisting of cooked apple, chestnuts and jujube; wherein the beans include small red bean and/or azuki bean; the cereals include one or more selected from the group consisting of rice, glutinous rice and sorghum rice; and wherein the antidiarrheal food can be one or more combinations in any ratio by weight, the method comprising: (1) washing the taro, peeling, steaming, heating for 5 to 30 minutes after the water boils, and drying under 120° C. to make powder; (2) washing the antidiarrheal food, cutting into pieces or pellets, boiling in water, continue heating for 5 to 30 minutes after the water boils, drying and crushing; (3) mixing the taro powder and antidiarrheal food powder according to the ratio, and sterilizing to get the composition; preferably, the heating in step (1) is continued for 10 to 15 minutes after the water boils; the drying temperature is less than or equal to 100° C.; more preferably, the drying temperature is less than or equal to 80° C.; and preferably, the heating in step (2) is continued for 15 to 20 minutes after the water boils.

10. (canceled)

Description

BEST MODE OF THE INVENTION

[0046] The components and ratio by weight of the composition of the present invention comprise the taro and antidiarrheal food in combination to feed children with diarrhea. The combination can be operated according to volume ratio or ratio by weight, preferably ratio by weight. It can be confirmed that the composition of the present invention has a good antidiarrheal effect within the above-mentioned ratio. The following examples are merely illustrative, and do not intent to limit the protection scope of the present invention.

[0047] In the first embodiment of the present invention, taking 100 kg of taro and antidiarrheal food respectively, washing the taro, peeling, steaming, heating for 5 to 30 minutes after the water boils, and drying under 120° C. to make powder; washing the antidiarrheal food, cutting into pieces or pellets, boiling in water, continually heating for 5 to 30 minutes after the water boils, drying and crushing; mixing the taro powder and antidiarrheal food powder according to the ratio, and sterilizing to get the composition.

[0048] Preferably, when preparing the taro powder, heating is continued for 10 to 15 minutes after the water boils, and the drying temperature is ≤100° C.; more preferably, the drying temperature is ≤80° C.

[0049] Preferably, when preparing the antidiarrheal food powder, heating is continued for 15 to 20 minutes after the water boils.

[0050] In the second embodiment of the present invention, the taro powder and antidiarrheal food powder prepared in Example 1 are mixed according to the ratio by weight to prepare the composition of the present invention. Preferably, the taro and the antidiarrheal food are formulated according to the following ratio by weight: 10-90% taro and 10-90% antidiarrheal food; preferably, 10-85% taro and 15-90% antidiarrheal food; more preferably, 15-80% taro and 20-85% antidiarrheal food; further preferably, 25-75% taro and 25-75% antidiarrheal food; further preferably, 30-70% taro and 30-70% antidiarrheal food; further preferably, 35-65% taro and 35-65% antidiarrheal food; further preferably, 40-60% taro and 40-60% antidiarrheal food; more preferably, 50% taro and 50% antidiarrheal food.

[0051] Within the above-mentioned ratio ranges, the ratio of taro and antidiarrheal food by weight may be 90% taro and 10% antidiarrheal food; 10% taro and 90% antidiarrheal food; 85% taro and 15% antidiarrheal food; 80% taro and 20% antidiarrheal food; 75% taro and 25% antidiarrheal food; 70% taro and 30% antidiarrheal food; 65% taro and 35% antidiarrheal food; 60% taro and 40% antidiarrheal food; 55% taro and 45% antidiarrheal food; 45% taro and 55% antidiarrheal food; 40% taro and 60% antidiarrheal food, 35% taro and 65% antidiarrheal food; 30% taro and 70% antidiarrheal food; 25% taro and 75% antidiarrheal food; 20% taro and 80% antidiarrheal food; or 15% taro and 85% antidiarrheal food. The ratio of the taro and the antidiarrheal food by weight can also be any ratio between the weight percentages of the above groups, such as 60-65% taro and 35-40% antidiarrheal food; 33-64% taro and 36-67% antidiarrheal food, etc.

[0052] Preferably, the taro is taro puree; the antidiarrheal food is in a pureed form.

[0053] The antidiarrheal food of the present invention includes one or more selected from the group consisting of vegetables, meats, fruits or nuts, beans and cereals.

[0054] The vegetables include one or more selected from the group consisting of carrot, broccoli, cauliflower, bok choy, purple sweet potato, Chinese yam, lotus root and lotus seed (with core removed).

[0055] The meats include one or more selected from the group consisting of beef, pork liver and pork.

[0056] The fruits or nuts include one or more selected from the group consisting of cooked apple, chestnuts and jujube.

[0057] The beans include small red bean and/or azuki bean.

[0058] The cereals include one or more selected from the group consisting of rice, glutinous rice and sorghum rice.

[0059] The antidiarrheal food of the present invention can be one or more combinations in any ratio by weight.

[0060] Preferably, the antidiarrheal food includes one or more selected from the group consisting of carrot, purple sweet potato, beef, chestnuts, jujube, small red bean, azuki bean, rice, glutinous rice and sorghum rice.

[0061] More preferably, the antidiarrheal food includes one or more selected from the group consisting of carrot, purple sweet potato, jujube, small red bean, azuki bean, rice, glutinous rice and sorghum rice.

[0062] Further preferably, the antidiarrheal food includes one or more selected from the group consisting of carrot, purple sweet potato, jujube, rice, glutinous rice and sorghum rice.

[0063] More preferably, the antidiarrheal food includes one or more selected from the group consisting of carrot, jujube, rice, glutinous rice and sorghum rice.

[0064] Furthermore preferably, the antidiarrheal food includes one or more selected from the group consisting of carrot, rice and glutinous rice.

[0065] The raw materials in each component in this embodiment can be combined arbitrarily, and each component can be formulated within a limited range, and the final prepared composition has the same antidiarrheal effect.

[0066] In the third embodiment of the present invention, the taro powder and antidiarrheal food powder prepared in Example 1 are mixed according to the ratio by weight to prepare the composition of the present invention. The antidiarrheal foods are combined according to a certain ratio by weight, and the ratio comprises the followings:

[0067] 10-70% vegetables, 5-30% meats, 5-60% fruits or nuts, 10-60% beans, and 10-70% cereals;

[0068] preferably, 20-40% vegetables, 10-20% meats, 10-40% fruits or nuts, 10-40% beans, and 20-40% cereals;

[0069] more preferably, 30% vegetables, 10% meats, 10% fruits or nuts, 20% beans, and 30% cereals.

[0070] In the composition of the present invention, preferably, the vegetables comprise one or more selected from the group consisting of carrot, broccoli, cauliflower, purple sweet potato, lotus root and lotus seed (with core removed).

[0071] The meats include one or more selected from the group consisting of beef, pork liver and pork.

[0072] The fruits or nuts include one or more selected from the group consisting of cooked apple and jujube.

[0073] The beans include small red bean and/or azuki bean.

[0074] The cereals include one or more selected from the group consisting of rice, glutinous rice and sorghum rice.

[0075] More preferably, the vegetables include one or more selected from the group consisting of carrot, broccoli, cauliflower and purple sweet potato.

[0076] Further preferably, the vegetables include one or two of carrot and purple sweet potato.

[0077] Furthermore preferably, the vegetable is carrot.

[0078] Within the above-mentioned ratio ranges, the ratio of the antidiarrheal food by weight may be 60% carrot, 10% beef, 5% jujube, 10% small red bean, and 15% rice; 30% broccoli, 15% pork, 25% steamed apple, 15% azuki bean, and 15% glutinous rice; 25% carrot and purple sweet potato, 10% beef, 20% jujube, 18% small red bean and azuki bean, and 27% rice and glutinous rice; 15% lotus seed, 20% pork liver, 15% jujube and cooked apple, 20% azuki bean, and 30% sorghum rice; or 30% carrot, 10% beef, 10% jujube, 20% small red bean, and 30% rice.

[0079] The raw materials in each component in this embodiment can be combined arbitrarily, and each component can be formulated within a limited range, and the final prepared composition has the same or similar antidiarrheal effect.

[0080] In the fourth embodiment of the present invention, the types of antidiarrheal foods are further limited. The antidiarrheal food is made of vegetables, fruits or nuts, beans and cereals in a ratio by weight. The ratio of the antidiarrheal food by weight comprises the followings:

[0081] 10-75% vegetables, 5-60% fruits or nuts, 10-60% beans, and 10-75% cereals.

[0082] Preferably, 10-60% vegetables, 10-40% fruits or nuts, 20-50% beans, and 10-60% cereals.

[0083] More preferably, 20-40% vegetables, 20-40% fruits or nuts, 20-40% beans, and 20-40% cereals.

[0084] Further preferably, 30% vegetables, 20% fruits or nuts, 20% beans, and 30% cereals.

[0085] In the composition of the present invention, preferably, the vegetables include one or more selected from the group consisting of carrot, broccoli, cauliflower, purple sweet potato, lotus root and lotus seed.

[0086] The fruits or nuts include one or more selected from the group consisting of cooked apple and jujube.

[0087] More preferably, the vegetables include one or more selected from the group consisting of carrot, broccoli, cauliflower and purple sweet potato.

[0088] Further preferably, the vegetables include one or two of carrot and purple sweet potato.

[0089] More preferably, the vegetable is carrot.

[0090] In this embodiment, the antidiarrheal food components remove the meat component. During the experiment, the inventor found that a small number of children with diarrhea had indigestion of meats, especially children with infectious diarrhea, so a vegetarian formula is applied.

[0091] The ratio of the components by weight comprises the followings: 40% cauliflower and purple sweet potato, 15% jujube, 25% small red bean, and 20% rice and glutinous rice; 30% carrot, 20% steamed apple, 20% azuki bean, and 30% glutinous rice; 25% carrot and purple sweet potato, 20% jujube, 25% small red bean and azuki bean, and 30% sorghum rice; 20% lotus root, 20% jujube and cooked apple, 30% azuki bean, and 30% glutinous rice; or 30% carrot, 20% jujube, 20% red bean, and 30% rice.

[0092] Of course, in addition to the specific proportions mentioned above, the raw materials in each component in this embodiment can be combined arbitrarily, and each component can be formulated within a limited range, and the final prepared composition has the same or similar antidiarrheal effect.

[0093] In the fifth embodiment of the present invention, the antidiarrheal food is made of vegetables and cereals in a ratio by weight. The ratio of the antidiarrheal food by weight comprises the followings:

[0094] 10-90% vegetables and 10-90% cereals.

[0095] Preferably, 25-75% vegetables and 25-75% cereals.

[0096] More preferably, 30-70% vegetables and 30-70% cereals.

[0097] Further preferably, 40-60% vegetables and 40-60% cereals.

[0098] Furthermore preferably, 50% vegetables and 50% cereals.

[0099] In the composition of the present invention, preferably, the vegetables include one or more selected from the group consisting of carrot, broccoli, cauliflower, purple sweet potato, lotus root and lotus seed.

[0100] More preferably, the vegetables include one or more selected from the group consisting of carrot, broccoli, cauliflower and purple sweet potato.

[0101] Further preferably, the vegetables include one or two of carrot and purple sweet potato.

[0102] More preferably, the vegetable is carrot.

[0103] In this embodiment, the inventor found that a small number of children are allergic to beans. If the peels of fruits or nuts are not completely removed, the digestive tract may also be affected. Therefore, the components of the product are further reduced, and the types of antidiarrheal foods are limited to vegetables and cereals.

[0104] The ratio of the components by weight comprises the followings: 80% carrot and 20% rice; 90% broccoli and carrot, and 10% glutinous rice; 25% purple sweet potato, and 75% rice and glutinous rice; 40% lotus seed, and 60% sorghum rice and glutinous rice; 45% cauliflower and broccoli, and 55% rice; 50% carrot and purple sweet potato, and 50% rice and glutinous rice, etc.

[0105] Of course, in addition to the specific proportions mentioned above, the raw materials in each component in this embodiment can be combined arbitrarily, and each component can be formulated within a limited range, and the final prepared composition has the same or similar antidiarrheal effect.

[0106] In the sixth embodiment of the present invention, in order to meet the need of growth and development of infants and young children, the trace elements and minerals can be added to the composition of the present invention to prepare a complete nutritional formula.

[0107] Preferably, the energy per 100 g of the composition is ≥1250 kJ; the nutrients per 100 kJ include:

[0108] protein ≥0.33 g, fat ≤0.8 g, vitamin A 14-43 μgRE, vitamin D 0.25-0.75 μg, vitamin B1≥12.5 μg, calcium ≥12 mg, iron 0.25-0.5 mg, zinc ≥0.17-0.46 mg, and sodium ≤24 mg;

[0109] the following contents of vitamins and minerals can also be added to the composition:

[0110] vitamin E 0.08-1.2 mg, vitamin B2≥13 μg, vitamin B6≥8.4 μg, vitamin B12≥0.02 μg, niacin ≥83.7 μg, folic acid ≥1.2 μg, pantothenic acid ≥50.4 μg, vitamin C≥1.4 mg, biotin ≥0.17 μg, phosphorus 8.4-30 mg, iodine 1.4-8.8 μg, and potassium 13-66 mg.

[0111] More preferably, in order to further meet the need of growth and development of infants under 1 year old during diarrhea, the nutrients and contents contained per 100 kJ in the composition of the present invention comprise: protein 0.45-0.7 g, fat 1.05-1.4 g, carbohydrate 2.2-3.3 g, vitamin A 14-43 μgRE, vitamin D 0.25-0.6 μg, vitamin E 0.12-1.2 mg, vitamin K1 1.0-6.5 μg, vitamin B1 14-72 μg, vitamin B2 19-119 μg, vitamin B6 8.5-45 μg, vitamin B12 0.02-0.36 μg, niacin 70-360 μg, folic acid 2.5-12 μg, pantothenic acid 96-478 μg, vitamin C 2.5-17 mg, biotin 0.4-2.4 μg, sodium 5-14 mg, potassium 14-43 mg, copper 8.5-29 μg, magnesium 1.2-3.6 mg, iron 0.1-0.36 mg, zinc 0.12-0.36 mg, manganese 1.2-24 μg, calcium 12-35 mg, phosphorus 6-24 mg, the ratio of calcium to phosphorus 1:1-2:1, iodine 2.5-14 μg, chlorine 12-38 mg, and selenium 0.48-1.9 μg;

[0112] preferably, the following contents of trace elements can also be added to the composition:

[0113] chromium 0.4-2.4 μg, molybdenum 0.4-2.4 μg, choline 1.7-12 mg, inositol 1-9.5 mg, taurine ≤3 mg, L-carnitine ≥0.3 mg, docosahexaenoic acid (% of total fatty acids) ≤0.5, and eicosatetraenoic acid (% of total fatty acids) ≤1.

[0114] Further preferably, in order to further meet the need of growth and development of children over 1 year old during diarrhea, the nutrients and content contained per 100 kJ in the composition of the present invention include: vitamin A 17.9-58.3 μgRE, vitamin D 0.25-0.75μg, vitamin E≥0.15 mg, vitamin K1≥1 μg, vitamin B1≥0.01 mg, vitamin B2≥0.01 mg, vitamin B6≥0.01 mg, vitamin B12≥0.04 μg, niacin ≥0.11 mg, folic acid ≥1 μg, pantothenic acid ≥0.07 mg, vitamin C≥1.8 mg, biotin ≥0.4 μg, sodium 5-20 mg, potassium 18-69 mg, copper 7-35 μg, magnesium ≥1.4 mg, iron 0.25-0.5 mg, zinc 0.1-0.4 mg, manganese 0.3-24 μg, calcium ≥17 mg, phosphorus 8.3-46.2 mg, the ratio of calcium to phosphorus 1:1-2:1, iodine ≥1.4 μg, chlorine ≤52 mg, and selenium 0.5-2.9 μg;

[0115] further preferably, the following content of trace elements can also be added to the composition: chromium 0.4-5.7 μg, molybdenum 1.2-5.7 μg, fluorine ≤0.05 mg, choline 1.7-19.1 mg, inositol 1-9.5 mg, taurine ≤3.1 mg, L-carnitine ≥0.3 mg, docosahexaenoic acid (% of total fatty acids) ≤0.5, eicosatetraenoic acid (% of total fatty acids) ≤1, nucleotides ≥0.5 mg, and dietary fiber ≤0.7 g.

[0116] The components of the composition comprise powder, puree form and granule; preferably powder. The powder of raw material can be purchased from the open market or self-made.

[0117] 3.5 to 7 grams each time for infants from 6 months to 3 years old , 2 to 3 times a day; and 5 to 10 grams each time for children over 36 months old, 2 to 3 times a day.

[0118] The composition of the present invention is suitable for the treatment and nutritional support of viral diarrhea, bacterial diarrhea, allergic diarrhea, lactose intolerant diarrhea, drug-induced diarrhea, congenital megacolon diarrhea or inflammatory bowel disease (IBD) diarrhea.

[0119] The pharmaceutical composition of the present invention has obvious antidiarrheal function. Those skilled in the art can change the components through equivalent substitutions, etc., but all fall within the protection scope of the present invention.

[0120] Test Example

EXPERIMENTAL EXAMPLE 1

Clinical Observation of the Composition of the Present Invention in Treating Viral Diarrhea

[0121] 1. Clinical Data

[0122] 1.1 General information. 108 children outpatients with diarrhea were randomly divided into treatment group (54 cases) and control group (54 cases). All cases had obvious dehydration before treatment, and the number of diarrhea in 24 hours was more than 5 times. There were 54 cases in the treatment group, including 31 boys and 23 girls, aged 1 to 5 years old, with an average of 2.7 years old. There were 54 cases in the control group, including 34 boys and 20 girls, aged from 1 to 4.8 years old, with an average of 2.4 years old. After statistical processing, the clinical data of the two groups are comparable (P>0.05).

[0123] 1.2 Treatment methods. The two groups were given symptomatic treatment such as rehydration. The treatment group orally took the composition prepared in Example 2 of the present invention with 50% taro, 25% carrot, 25% rice and glutinous rice in the ratio by weight. For infants with diarrhea from 6 months to 3 years old, 3.5 grams of the pharmaceutical composition were rinsed with warm water and taken orally, 6 times a day. For children with diarrhea over 3 years old, 7 grams the pharmaceutical composition were rinsed with warm water and taken orally, 3 times a day. Taking for 3 consecutive days is one course of treatment. The frequency and severity of diarrhea were observed, and routine blood tests, urine tests, liver function tests and kidney function tests were carried out before and after treatment. The control group took the eight-sided montmorillonite powder orally according to the method and dosage of the instructions.

[0124] 1.3 The standardization of efficacy evaluation is based on “Diagnostic Criteria and Principles of Treatment of Infectious Diarrhea”. Significantly effective: diarrhea frequency in 24 h≤2 times; Effective: 3 times≤diarrhea frequency in 24 h≤5 times; and Ineffective: diarrhea frequency in 24 h>5 times, the diarrhea frequency is not significantly reduced or excreting watery stools.

[0125] 2. Results

[0126] 2.1 Comparison of the treatment effect for diarrhea between the two groups is shown in Table 1.

TABLE-US-00001 TABLE 1 Comparison of the treatment effect for diarrhea between the two groups Signifi- Total cantly Effec- Ineffec- effective Effective tive tive rate Groups Cases n % n % n % % Treatment 54 49 90.74 4  7.41 1 1.85 98.15 group Control 54 43 79.63 6 11.11 5 9.26 90.74 Group

[0127] 3. Discussion

[0128] Both the composition of the present invention and the control group have the effects of treating diarrhea and constricting the intestinal tract. The effect of the composition group of the invention is better than that of the control group.

EXPERIMENTAL EXAMPLE 2

[0129] Clinical observation of the pharmaceutical composition of the present invention in treating diarrhea caused by lactose intolerance and milk protein allergy diarrhea in infants and children.

[0130] 1. Clinical Data

[0131] 1.1 General information. 100 outpatients with persistent diarrhea caused by lactose intolerance and milk protein allergy were randomly divided into treatment group (50 cases) and control group (50 cases). There were 80 children with lactose intolerance and persistent diarrhea, 60 children with milk protein allergy, and 40 children with milk protein allergy and lactose intolerance. All cases had symptoms of diarrhea after consuming breast milk or hydrolyzed formula powder containing lactose before treatment. Diarrhea occurred half an hour after breastfeeding and was detected as lactose intolerance and/or milk protein allergy. There were 50 cases in the treatment group, including 35 boys and 15 girls, aged from 6 months to 3 years old, with an average of 1.6 years old. There were 50 cases in the control group, including 26 boys and 24 girls, aged from 7 months to 2.5 years old, with an average age of 1.4 years old. After statistical processing, the clinical data of the two groups are comparable (P>0.05).

[0132] 1.2 Therapeutic method. The treatment group orally took the composition prepared in Example 2 of the present invention with 25% taro, 20% carrot, 30% rice and 25% glutinous rice in the ratio by weight. For infants with diarrhea from 6 months to 3 years old, 3.5 grams of the pharmaceutical composition were rinsed with warm water and taken orally, 6 times a day. For children with diarrhea over 3 years old, 7 grams the pharmaceutical composition were rinsed with warm water and taken orally, 3 times a day. Taking for 5 consecutive days is one course of treatment. The frequency of diarrhea was observed before and after treatment. The control group orally took lactase according to the method and dosage of the instructions.

[0133] 1.3 The standardization of efficacy evaluation. Significantly effective: diarrhea frequency in 4 hours after feeding ≤1 time; Effective: 1 time<diarrhea frequency in 4 hours after feeding ≤2 times; and Ineffective: diarrhea frequency in 4 hours after feeding ≥3 times, the diarrhea frequency is not significantly reduced or there is no obvious reduction in watery stools.

[0134] 2. Results

[0135] 2.1 Comparison of the treatment effect for diarrhea between the two groups is shown in Table 2.

TABLE-US-00002 TABLE 2 Comparison of the treatment effect for diarrhea between the two groups Signifi- Total cantly Effec- Ineffec- effective Effective tive tive rate Groups Cases n % n % n % % Treatment 50 37 74.00 11 22.00 2  4.00 96.00 group Control 50 28 56.00 13 26.00 9 18.00 82.00 Group

[0136] 3. Discussion

[0137] Both the composition of the present invention and the control group have the effects of treating diarrhea caused by lactose intolerance and milk protein allergy and constricting the intestinal tract. The effect of the composition group of the invention is better than that of the control group.