Vitamin preparation

Abstract

The invention relates to a vitamin preparation, especially for application to the skin, containing a physiologically effective amount of vitamin B12 or another precursor of coenzyme B12, a polysorbate as well as customary carrier substances for the formation of a gel matrix.

Claims

1. A method of treating skin, comprising applying to the skin a vitamin preparation containing: vitamin B12 or a precursor thereof in an amount in the range of 40 to 100 mg per 100 g of the preparation, polysorbate 20 in an amount limited to the range of 20 to 100 mg per 100 g of the preparation as an entrainer, and customary carrier substances for the formation of a carrier matrix designed for the application of the preparation to the skin, and limiting the range of the vitamin B12 or precursor to an amount whereby to introduce said vitamin B12 or the precursor thereof into layers of skin consisting essentially of the epidermis.

2. A method according to claim 1 wherein said preparation contains polyhexanide.

3. A method according to claim 2 wherein said preparation contains 50 to 500 mg of a 20% polyhexanide solution per 100 g of the preparation.

4. A method according to claim 1 wherein said preparation contains urea.

5. Vitamin preparation according to claim 1 wherein said preparation contains a zinc salt.

6. A method according to claim 1 wherein said preparation contains 50 to 1000 mg of zinc salt per 100 g of the preparation.

7. A method according to claim 1 wherein said preparation contains taurine, lysine, caffeine, and/or creatine.

8. A method according to claim 1 wherein said preparation contains dexpanthenol.

9. A method according to claim 8 wherein said preparation contains 500 to 10000 mg of dexpanthenol per 100 g of the preparation.

10. A method according to claim 1 in which the vitamin preparation is in gel form and wherein said preparation contains 40 to 100 mg of vitamin B12 or another precursor of coenzyme B12 50 to 500 mg polyhexanide in 20% aqueous solution 20 to 100 mg of polysorbate 20 1000 to 5000 mg of glycerin 500 to 5000 mg of hydroxyethyl cellulose 400 2500 to 7000 mg of urea citric acid for buffering to pH 5.4 NaOH for buffering to pH 5.4 as well as demineralized water ad 100 g.

11. A method according to claim 10 wherein said preparation additionally contains 1000 mg to 4000 mg of PEG400.

12. A method according to claim 1 wherein said preparation is contained on/in a pad for application to the skin, as spray or tincture for application to mucous membranes.

13. A method according to claim 12 for the treatment of irritation phenomena of the skin and mucous membranes.

14. A method for treating skin, comprising applying to the skin a vitamin preparation containing: vitamin B12 or a precursor thereof in an amount in the range of 40 to 100 mg per 100 g of the preparation, polysorbate 20 in an amount limited to the range of 20 to 100 mg per 100 g of the preparation as an entrainer, dexpanthenol, and customary carrier substances for the formation of a carrier matrix designed for the application of the preparation to the skin, and limiting the range of the vitamin B12 or precursor to an amount whereby to introduce said vitamin B12 or the precursor thereof into layers of skin consisting essentially of the epidermis.

Description

EXAMPLE 1

(1) A vitamin preparation in gel form was produced using the following constituents:

(2) TABLE-US-00001 1. Vitamin B12 (cyanocobalamin) 70 mg 2. Polyhexanide solution concentrate 200 mg 20% (m/V) 3. Polysorbate 20 40 mg 4. Glycerin 2500 mg 5. Hydroxyethyl cellulose 400 up to 5000 mg. depending on the desired consistency 6. Urea 5000 mg 7. Citric acid 300 mg for buffering to pH 5.4 8. If expedient, NaOH for buffering to pH 5.4 9. Demineralized water ad 100 g

(3) The constituents are moderately heated and mixed and then stirred to produce a gel.

EXAMPLE 2

(4) The preparation listed in Example 1 is supplemented by 5000 mg of dexpanthenol and 2000 mg of PEG400.

(5) Further constituents may be admixed, for example 300 mg of taurine, 25 mg of caffeine, 1000 mg of lysine, 500 g of zinc sulfate, and/or 500 mg of creatine. Sodium ascorbate is added in case an oxidation inhibitor is needed.

EXAMPLE 3

(6) Antiallergenic eyedrops were prepared as follows:

(7) TABLE-US-00002 1. Vitamin B12 70 mg 2. Dexpanthenol 500 mg  3. Polyhexanide (solution concentrate 20% (m/V)) 0.75 mg   4. Polysorbate 20 40 mg 5. HPMC 10 mg 6. Trisodium citrate 10 mg 7. Citric acid ad pH 7.2 8. Sodium hydroxide ad pH 7.2 9. Sodium chloride for adjustment to 300 mosmol 10. Demineralized water ad 100 g

EXAMPLE 4

(8) An agent for contact lens care was prepared as follows:

(9) TABLE-US-00003 1. Vitamin B12 70 mg 2. Polyhexanide (solution concentrate 20% (m/V)) 0.75 mg   3. Polysorbate 20 40 mg 4. HPMC 10 mg 5. Trisodium citrate 10 mg 6. Citric acid ad pH 7.2 7. Sodium hydroxide ad pH 7.2 8. Sodium chloride for adjustment to 300 mosmol 9. Demineralized water ad 100 g

EXAMPLE 5

(10) Nasal spray/drops were prepared according to the following formulation:

(11) TABLE-US-00004 1. Vitamin B12 (cyanocobalamin) 70 mg 2. Dexpanthenol 500 mg 3. Polyhexanide (solution concentrate 20% (m/V)) 0.15 mg 4. Polysorbate 20 40 mg 5. HPMC 100 mg 6. Trisodium citrate 25 mg 7. Citric acid ad pH 7.2 8. Sodium chloride 0.9 to 2.0 g to achieve a hypertonic decongestant solution 9. Demineralized water ad 100 g

Patient Study

(12) Seven patients suffering from neurodermatitis with eczema on palms, arms, and partially face causing considerable itchiness were treated topically with the gel described in Example 1. Immediately after treatment the itchiness abated and disappeared after a few minutes. Pustules and swellings disappeared after one day, redness on the following day at the latest.

(13) Administering the gel to five patients suffering from psoriasis resulted in the immediate abatement of the itchiness and diminishing of the redness the clay after. Treatment of two patients with dermatoses on the head resulted in dermatoses disappearing within a week.

(14) A preparation according to Example 3 was administered to the eyes of ten allergic persons suffering from conjunctivitis due to airborne pollen. The itchiness disappeared immediately, the signs of inflammation most widely disappeared after three hours at the latest.