Cosmetic use of spiculisporic acid as a deodorant active agent

Abstract

The invention relates to the cosmetic use, as a deodorant active agent, of spiculisporic acid in free form, partially or fully neutralised by at least one mineral and/or organic base. The invention also relates to a cosmetic method for treating human body odours, in particular the armpits or feet, in which at least one spiculisporic acid as defined above or a composition containing same in a physiologically acceptable medium is applied to the human keratin material.

Claims

1. A cosmetic process for treating human body odors which comprises applying to human keratin materials, as a deodorant active agent, at least one of: a neutralized spiculisporic acid in a form that is partially neutralized with at least one mineral base, totally neutralized with at least one mineral base, partially neutralized with at least one organic base, totally neutralized with at least one organic base, or combinations thereof; or a composition containing the at least one neutralized spiculisporic acid in a physiologically acceptable medium.

2. The process as claimed in claim 1, in which the neutralized spiculisporic acid is contained in a composition comprising a physiologically acceptable medium.

3. The process as claimed in claim 2, in which the neutralized spiculisporic acid is present in the composition in a content of between 0.1% and 15% by weight relative to the total weight of the composition.

4. The process as claimed in claim 2, in which the neutralized spiculisporic acid is contained in a composition comprising at least one surfactant.

5. The process as claimed in claim 2, in which the neutralized spiculisporic acid is in a form that is partially neutralized with at least one organic base, or totally neutralized with at least one organic base.

6. The process as claimed in claim 2, in which the organic base is chosen from the group formed from basic amino acids, basic oligopeptides, basic amines, and mixtures thereof.

7. The process as claimed in claim 1, in which the neutralized spiculisporic acid is in a form that is partially neutralized with at least one organic base, or totally neutralized with at least one organic base.

8. The process as claimed in claim 7, in which the organic base is chosen from the group formed from basic amino acids, basic oligopeptides and basic amines, and mixtures thereof.

9. The process as claimed in claim 1, in which the organic base is chosen from the group formed from basic amino acids, basic oligopeptides and basic amines, and mixtures thereof.

10. The process as claimed in claim 1, in which the organic base is chosen from the group formed from arginine and triethanolamine, and mixtures thereof.

11. The process as claimed in claim 1, in which the ratio R.sub.1 of the number of moles of the base to the number of moles of the neutralized spiculisporic acid is strictly greater than 1.0.

12. The process as claimed in claim 1, in which the ratio R.sub.1 of the number of moles of the base to the number of moles of the neutralized spiculisporic acid is strictly greater than 1.0 and less than or equal to 2.50.

13. The process as claimed in claim 1, in which the ratio R.sub.1 of the number of moles of the base to the number of moles of the neutralized spiculisporic acid is greater than or equal to 1.10 and less than or equal to 2.0.

14. A cosmetic process for treating human body odors which comprises applying to human keratin material selected from the group consisting of armpits or feet: at least one neutralized spiculisporic acid as claimed in claim 1; or a composition containing the at least one neutralized spiculisporic acid as claimed in claim 1 in a physiologically acceptable medium.

15. The process as claimed in claim 1, in which the neutralized spiculisporic acid is contained in a composition comprising a physiologically acceptable medium that also comprises an aqueous phase.

16. The process as claimed in claim 1, in which the organic base is arginine.

17. The cosmetic method as claimed in claim 1, wherein the at least one neutralized spiculisporic acid acts to treat human body odors by reducing the growth of Corynebacterium xerosis.

18. The process as claimed in claim 1, in which the at least one neutralized spiculisporic acid is contained in a composition comprising a physiologically acceptable medium, and is applied to human keratin material in the form of a roll-on or stick.

19. The process as claimed in claim 1, wherein the at least one neutralized spiculisporic acid is applied to armpits.

Description

EXAMPLE 1—COMPOSITIONS A AND B ACCORDING TO THE INVENTION

(1) Two compositions A and B according to the invention comprising spiculisporic acid were prepared according to a process that is standard for those skilled in the art, such as that given below; dispersion of spiculisporic acid in water with stirring at room temperature gradual addition with stirring of the base to obtain the mole ratio R1 nmole base/nmoles S-acid=1.1

(2) The mass of base to be used to neutralize the spiculisporic acid (S-acid) is defined in the following manner

(3) ${\mathrm{mass}}_{\left(\mathrm{base}\right)}g=2\times \frac{{\mathrm{mass}}_{\left(S\text{-}\mathrm{acid}\right)}g}{{\mathrm{MM}}_{\left(S\text{-}\mathrm{acid}\right)}g.Math.{\mathrm{mol}}^{-1}}\times {\mathrm{MM}}_{\left(\mathrm{base}\right)}g.Math.{\mathrm{mol}}^{-1}$

(4) Empirical formulae and molecular masses of spiculisporic acid and of various bases that may be used according to the invention:

(5) TABLE-US-00001 Molar mass Empirical formula (g .Math. mol.sup.−1) Spiculisporic acid C.sub.17H.sub.28O.sub.6 328.4 Sodium hydroxide NaOH 40 Potassium hydroxide KOH 56.1 Triethanolamine (TEA) C.sub.6H.sub.15NO.sub.3 149.19 L-Arginine C.sub.6H.sub.14N.sub.4O.sub.2 174.2

(6) Composition of the Formulations Prepared:

(7) TABLE-US-00002 Composition Composition A: % of the B: % of the Ingredients ingredients ingredients Arginine (available under the name L- Ratio R.sub.1 = 1.1 Ratio R.sub.1 = 1.1 arginine ® sold by the company 5.84 2.92 Ajinomoto) Spiculisporic acid (available under 10 5 the name Spiculisporic acid ® sold by the company Iwata Chemical) Water 84.16 92.08

EXAMPLE 2: DEMONSTRATION OF THE BACTERICIDAL ACTIVITY ON THE MICROORGANISM CORYNEBACTERIUM XEROSIS OF A COSMETIC COMPOSITION CONTAINING SPICULISPORIC ACID

(8) Principle

(9) Quantitative determination of the activity of a cosmetic formulation on Corynebacterium xerosis, a microorganism involved in phenomena associated with underarm odor. This microorganism is placed under optimum growth conditions.

(10) Protocol The model strain used is: Corynebacterium xerosis, Institut Pasteur Collection CIP 5216 (bacterium)

(11) The strain is placed in contact with the test formulation in a suitable liquid culture medium in the following ratios: 10% of the microbial inoculum at 10.sup.8 microorganisms/ml 10% of the test formulation 80% of liquid culture medium (tryptocasein soya broth)

(12) In parallel, a growth control, in which the test formulation is replaced with diluent (tryptone salt), is prepared under the same conditions.

(13) The samples are placed in a rotary incubator at 35° C. and agitated throughout the duration of the test.

(14) After 2, 6 and 24 hours of contact, the number of live microorganisms remaining in the mixture is evaluated.

(15) The results are expressed as a logarithm of the number of microorganisms per milliliter of mixture.

(16) Compositions Compositions A and B according to the invention comprising spiculisporic acid, and control composition tested:

(17) Composition A: aqueous 10% solution of spiculisporic acid neutralized with a base in a ratio Rbase/RS-acid=1.1

(18) Composition B: aqueous 5% solution of spiculisporic acid neutralized with a base in a ratio Rbase/RS-acid=1.1

(19) Results

(20) 24 hours after inoculation with 10% of a microbial inoculum containing 10.sup.8 microorganisms/ml, a decontamination of 6.6 Log and 4.9 Log relative to the growth control was obtained, respectively, with compositions A and B.

(21) The change in the number of microorganisms per milliliter of sample (in Log) is presented in the tables below:

(22) TABLE-US-00003 difference C. xerosis (log) after 24 hours of C. xerosis (log) contact time relative at t0 t2 h t6 h t24 h to the control Composition A 7.1 <1.3 <1.3 1.3 <−6.6 control 7.1 7.1 7.0 7.9

(23) Relative to the growth controls, composition A has excellent activity on C. xerosis from 2 hours of contact (more than 5 Log of reduction).

(24) TABLE-US-00004 difference C. xerosis (log) after 24 hours of C. xerosis (log) contact time relative to at t0 t2 h t6 h t24 h the control Composition B 7.1 4.4 3.5 3.0 −4.9 control 7.1 7.1 7.0 7.9

(25) Relative to the growth controls, composition B has excellent antimicrobial activity on C. xerosis (reduction of 5 Log at 24 hours).

(26) Spiculisporic acid in free form or in a form partially or totally neutralized with at least one mineral and/or organic base may thus be used in a composition that can thus inhibit the growth of Corynebacterium xerosis, of use for the treatment of unpleasant odors produced by the decomposition of sweat.

EXAMPLE 2: DEODORANT FORMULATION: ROLL-ON

(27) (Mass % Relative to the Total Mass of the Composition)

(28) TABLE-US-00005 Fragrance 0.7 Xanthan gum 0.6 Propanediol 5 96% alcohol and water 45 Spiculisporic acid 5 Arginine 2.92 Glyceryl caprylate 1.5 Water qs 100

(29) The composition produces a deodorant effect.

EXAMPLE 3: DEODORANT FORMULATION: ROLL-ON

(30) (Mass % Relative to the Total Mass of the Composition)

(31) TABLE-US-00006 Fragrance 1 Xanthan gum 0.4 Pectin 2 Mixture of: Caprylic/capric acid triglycerides Jojoba oil, and Dioctyl ether 20 Spiculisporic acid 5 Arginine 3 Calcium carbonate 0.05 Preserving agent 0.5 Water qs 100

(32) The composition produces a deodorant effect.