HIGHLY-PERMEABLE DENSE HOLLOW FIBER MEMBRANE FOR BLOOD OXYGENATION

Abstract

The present invention provides a highly-permeable dense hollow fiber membrane (HFM) for blood oxygenation. A membrane material plays a key role in an oxygenator, which determines the oxygenation efficiency, service life and safety of the oxygenator. The HFM according to the present invention features high permeability. When blood rich in carbon dioxide flows through the oxygenator, the carbon dioxide and oxygen in the blood can be rapidly exchanged, so that the blood can be rapidly updated, and the size of the oxygenator and the blood perfusion volume can be reduced. In addition, the membrane surface of the present invention is hydrophobic and dense, and blood does not directly contact with gas or permeate into a gas pipeline, thus avoiding the problems of protein leakage, permeability reduction and the like. The oxygenator prepared by using the HFM of the present invention can be repeatedly used for a long time.

Claims

1. A highly-permeable dense hollow fiber membrane (HFM) for blood oxygenation, wherein the membrane is prepared from Teflon AF 2400 and Teflon AF1600 materials, and features high permeability, desirable hydrophobicity and optimal biocompatibility.

2. The HFM according to claim 1, wherein the HFM is a dense membrane with a pore diameter of 0.01-0.1 nm.

3. The HFM according to claim 1, wherein the HFM has a thickness of 5-100 um.

4. The HFM according to claim 1, wherein a hollow fiber of the HFM has an inner diameter of 20-500 μm.

5. The HFM according to claim 1, wherein the HFM has a length of 0.01-1 m.

6. The HFM according to claim 1, wherein the HFM is formed by a melt extrusion forming method or a solvent casting method.

7. The HFM according to claim 1, wherein the HFM is applied to an in vivo oxygenation process or an extracorporeal blood oxygenation process.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0014] FIG. 1 is a schematic diagram of a characterization device for a membrane material oxygenation rate in Example 1 of the present invention; and

[0015] FIG. 2 is a microscopic view of a single hollow fiber of a HFM in Example 1 of the present invention.

DETAILED DESCRIPTION

[0016] A material and miniature device for extracorporeal blood oxygenation according to the present invention will be described and illustrated in detail below with specific examples. In order to enable technicians to better understand the present invention, the examples cannot be understood as limiting the protection scope of the present invention.

Example 1

[0017] A device essentially composed of a blood pump 1, a gas mass flow meter 2, an oxygenator 3, a thermostatic water bath 4 is provided. As shown in FIG. 1, the thickness and length of HFM and the diameter of the hollow fiber shown in FIG. 2 were optimized to achieve the optimal oxygenation efficiency. Specific implementation steps are as follows. [0018] (1) Blood rich in carbon dioxide was continuously injected into an inner tube of an oxygenator 3 through the blood pump 1; at the same time, oxygen was continuously introduced into an outer tube, and the oxygen flow rate was controlled by the gas mass flow meter 2; the blood flow rate was regulated by the blood pump, the blood flow rate was constant at 2 ml/min, the oxygen flow rate was 4 ml/min, the blood oxygenation process was kept at 37° C., and the pressure drop of a blood pipeline was measured by a micro pressure sensor. [0019] (2) A small amount of blood was taken from an outlet of the oxygenator, the oxygen concentration was measured through a blood-gas analyzer, and the oxygenation efficiency of the HFM material was analyzed under different implementation conditions. [0020] (3) The length of the HFM was kept at 0.4 m and the inner diameter of a hollow fiber was 200 um, and when the thicknesses of the HFM were 20 um, 40 um, 60 um, 80 um and 100 um respectively, the oxygenation rates of the dense HFM were 0.188, 0.175, 0.123, 0.0101 and 0.007 mL/min respectively. [0021] (4) The thickness of the HFM was kept at 40 um and the inner diameter of the hollow fiber was 200 μm, and when the lengths of the HFM were 0.1 m, 0.2 m, 0.4 m, 0.6 m and 0.8 m respectively, the oxygenation rates of the dense HFM were 0.08, 0.14, 0.18, 0.184 and 0.188 mL/min respectively. [0022] (5) The thickness of the HFM was kept at 40 μm and the length was 0.4 m, and when the inner diameters of the hollow fiber were 50 μm, 100 μm, 200 μm, 400 μm and 500 μm respectively, the oxygenation rates of the dense HFM were 0.189, 0.181, 0.175, 0.121 and 0.081 mL/min respectively.

Example 2

[0023] A device essentially composed of a blood pump 1, a gas mass flow meter 2, an oxygenator 3, a thermostatic water bath 4 is provided. As shown in FIG. 2, a microscopic view of a single hollow fiber of an HFM is characterized. Specific implementation steps are as follows. [0024] (1) Blood rich in carbon dioxide was continuously injected into an inner tube of an oxygenator through the blood pump; at the same time, oxygen was continuously introduced into an outer tube, and the oxygen flow rate was controlled by the gas mass flow meter; the blood flow rate was regulated by the blood pump, the blood flow rate was constant at 2 ml/min, the oxygen flow rate was 4 ml/min, the blood oxygenation process was kept at 37° C., and the pressure drop of a blood pipeline was measured by a micro pressure sensor. The HFM had a length of 0.4 m and a thickness of 40 μm, and the hollow fiber has an inner diameter of 200 μm. [0025] (2) A small amount of blood was taken from an outlet of the oxygenator, the oxygen concentration was measured through a blood-gas analyzer, and the oxygenation efficiency of the HFM material under different oxygenation time was analyzed. The obtained results are shown in Table 1.

[0026] Table 1 shows the change of oxygenation rate of the HFM under different oxygenation time in Example 2 of the present invention.

TABLE-US-00001 TABLE 1 Oxygenation time (day) Oxygenation rate (mL/min) 1 0.173 5 0.175 10 0.176 20 0.173 40 0.178 60 0.175

[0027] The technical solution of the present invention has been described in detail by the foregoing examples. Obviously, the present invention is not limited to the described examples. Based on the examples of the present invention, those skilled in the art can also make various changes accordingly, and any changes equivalent to or similar to the present invention fall within the protection scope of the present invention.